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CD4 Cells
By Afsath Jameela

CD4 Cells
Treatment centers need consulting rooms, offices, waiting rooms and secure storage for valuable drugs. They also require basic facilities to test for anemia, pregnancy, renal function, white blood cell counts and other factors that may affect treatment.
In developed countries, decisions about when to start treatment are based on the results of clinical tests called the CD4 test and the viral load test. Ideally these tests should be used everywhere, but in many parts of the world they are currently unavailable, as they require expensive equipment, electricity and trained technicians. In theory, decisions about when to start treatment may be based on symptoms alone. However in practice some treatment programmers provide medication only to people who have had a CD4 count.
There are two primary types of T-cells.
1. CD4 Cells-These cells have molecules called CD4 on its surface. These "helper" cells initiate the body's response to invading micro-organisms such as viruses.
2.CD8 Cells-These types of T-cells have a molecule called CD8 on their surface. CD8 cells destroy cells that have been infected with foreign invading micro-organisms. CD8 cells also produce antiviral substances (antibodies) that help fight off the foreign invader.
3.Normal values-In a healthy adult, a normal CD4 count can vary a great deal but is typically 600 to 1200 cells per cubic millimeter of blood
Between 600 and 350- In an HIV+ person, this range is considered "very good".
HIV medications are typically not be indicated.
Between 350 and 200-The immune system is weakened and therefore the HIV+ person may be at increased risk for infection and illness.
Function of T helper cells: Antigen presenting cells present antigen on their Class II MHC molecules. Helper T cells recognize these, with the help of their expression of CD4 co-receptor. The activation of a resting helper T cell causes it to release cytokines and other stimulatory signals. The importance of CD4 T cells is demonstrated with infection.
It has been proposed that during the non-symptomatic phase of infection, the virus has a relatively low affinity towards T cells (and has a higher affinity for macrophages), resulting in a slow kill rate of CD4+ T cells by the immune system. This is initially compensated for via the production of new helper T cells from thymus. Once the virus becomes T-tropic, it begins to infect CD4+ T cells far more efficiently, and

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the immune system is overwhelmed.
At this point, functional CD4+ T cell levels begin to decrease, eventually to a point where the CD4+ T cell population is too small to recognize the full range antigens that could potentially be detected. The lack of full antigen cover results in the core symptoms of acquired immune deficiency syndrome (AIDS).CD4 T cell depletion during AIDS allows various pathogens to escape T cell recognition, thus allowing opportunistic infections that would normally elicit a helper T cell response to bypass the immune system. While these complete bypass situations only occur when the helper T cell response is absolutely necessary for infection clearance, most infections increase in severity and/or duration because the immune system's helper T cells provide a weaker contribution to a less efficient immune response.
Two components of the immune system are particularly affected in AIDS, due to its CD4+ T cell dependency:
CD8+ T cells are not stimulated as effectively during the AIDS period of infection, making AIDS patients very susceptible to most viruses, including itself. This decline in killing of CD4+ T cells results in the virus being produced for a longer period (the infected CD4+ T cells are not killed as quickly), increasing the proliferation of the virus, and accelerating the development of the disease.
Antibody class switching declines significantly once helper T cell function fails. The immune system loses its ability to improve the affinity of their antibodies, and are unable to generate B cells that can produce antibody groups such as IgG and IgA. These effects are primarily due to the loss of any helper T cell that can interact with the B lymphocyte correctly. Another symptom of AIDS is the reduction in antibody levels due to a decrease in Th2 cytokines (and less interactions by helper T cells). All of these complications result in an increased susceptibility to aggressive bacterial infections, especially in areas of the body not accessible by IgM antibodies.
If the patient does not respond to Treatment they will succumb usually to either cancers or infections; the immune system finally reaches a point where it is no longer coordinated or stimulated enough to deal with the disease.

 Keywords:  HIV,AIDS,HIV Cure,HIV Treatment,HIV Infection,HIV Dating,HIV Positive,HIV Symptoms.


Afsath Jameela is a successful lady writer from Kairo. She right now living in UK.

Prevalence of opportunistic infections in HIV-positive patients in Bahrain: a four-year review (2009-2013).
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HIV Encephalopathy: pediatric case series description and insights from the clinic coalface.
CONCLUSIONS: Amongst the cohort of children referred to this clinic, the diagnosis of HIVE was unrecognized in the general medical services, even in its most severe form. Developmental delay and school failure were major presenting problems. Co-morbidities are a frequent finding and should be sought actively in order to optimize management and promote best possible outcomes for this vulnerable group of children. PMID: 25598835 [PubMed] (Source: AIDS Research and Therapy)
Pharmacokinetics of chewed vs. swallowed raltegravir in a patient with AIDS and MAI infection: some new conflicting data.
CONCLUSIONS: We found no evidence that chewed 400 mg semi-daily raltegravir in rifampicin co-medication leads to optimized pharmacokinetics. There is need for more data from randomized trials for further recommendations. PMID: 25598834 [PubMed] (Source: AIDS Research and Therapy)
Ethnopharmacological surveys and pharmacological studies of plants used in traditional medicine in the treatment of HIV/AIDS opportunistic diseases in Gabon
Conclusion It is concluded that some of these plants might be submitted to further scientific studies, including the identification and isolation of bioactive principles, that could be developed to drugs for the treatment of HIV/AIDS opportunistic diseases. Graphical abstract (Source: Journal of Ethnopharmacology)
A Blizzard Couldn't Stop These People From Helping Those In Need
For some New Yorkers, Monday's blizzard conditions meant braving the cold for the sake of others who needed some help. Although the winter storm fell short of historic expectations when it blew through New York City on Monday night, it did blanket the five boroughs with 7 to 9 inches of snow and created plenty of dangerous winds. While many New Yorkers were curled up under blankets waiting for the storm to pass, several organizations were hard at work, helping bring food, warmth and shelter to those who could use it most. Here are four groups that were helping vulnerable residents get through Monday night safely: Coalition for the Homeless Volunteers pass out food and winter clothing items to the needy on Monday night. Photo: Juan De La Cruz Coalition for the Homeless helps those in...
A Systematic Review of Recent Smartphone, Internet and Web 2.0 Interventions to Address the HIV Continuum of Care
Abstract eHealth, mHealth and ?Web 2.0? social media strategies can effectively reach and engage key populations in HIV prevention across the testing, treatment, and care continuum. To assess how these tools are currently being used within the field of HIV prevention and care, we systematically reviewed recent (2013?2014) published literature, conference abstracts, and funded research. Our searches identified 23 published intervention studies and 32 funded projects underway. In this synthesis we describe the technology modes applied and the stages of the HIV care cascade addressed, including both primary and secondary prevention activities. Overall trends include use of new tools including social networking sites, provision of real-time assessment and feedback, gamification ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Kenya: Condom Advert - HIV Prevention or Infidelity Promotion?
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Rice-size implant that boosts hearing and cuts ear infections 
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Determinants of Antiretroviral Therapy Adherence among Women in Southern Malawi: Healthcare Providers' Perspectives.
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Malawi: Man Convicted for Defiling and Infecting Child With HIV
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Nigeria: Sokoto State Govt. Disburses N80 Million to 16 NGOs in 2014 to Curb HIV/Aids Pandemic - Official.
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Are medications' adverse cognitive effects reversible?
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Cutaneous Epstein?Barr virus?associated lymphoproliferative polymorphic disease ? AIDS presenting manifestation
(Source: Journal of the European Academy of Dermatology and Venereology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Highlights of the 2014 International AIDS Conference: update from down under.
This article summarizes an IAS-USA continuing education webinar presented by Paul A. Volberding, MD, in August 2014, in which he focused on a few select highlights from the Conference. PMID: 25612178 [PubMed - in process] (Source: Topics in antiviral medicine)
Rapid tests for HIV type discrimination in West Africa may perform differently.
Authors: Hønge BL, Jespersen S, Olesen JS, Erikstrup C, Wejse C PMID: 25609215 [PubMed - in process] (Source: Journal of the International AIDS Society)
Amphetamine-type stimulants and HIV infection among men who have sex with men: implications on HIV research and prevention from a systematic review and meta-analysis.
CONCLUSIONS: While meth/amphetamine use was significantly associated with HIV infection among MSM in high-income countries in all study designs, evidence of the role of ecstasy in HIV infection was lacking in cross-sectional studies. Cross-sectional study design, measurement approaches and source populations may also be important modifiers of the strength and the direction of associations. Event-specific measure of individual drug is required to establish temporal relationship between ATS use and HIV infection. HIV prevention programmes targeting MSM should consider including interventions designed to address meth/amphetamine use. PMID: 25609214 [PubMed - in process] (Source: Journal of the International AIDS Society)
HIV/AIDS and lipodystrophy: Implications for clinical management in resource-limited settings.
CONCLUSIONS: Lipodystrophy is common in resource-limited settings, and has considerable implications for risk of metabolic diseases, quality of life and adherence. Comprehensive evidence-based interventions are urgently needed to reduce the burden of HIV and lipodystrophy, and inform clinical management in resource-limited settings. PMID: 25598476 [PubMed - in process] (Source: Journal of the International AIDS Society)
Cannabinoids: Now and in the Future (FR431)
Cannabinoids target orphan receptors GPR-55 and GPR-18, ion channels, monoamine receptors, and mu receptors. Cannabinoids have labeled indications for chemotherapy-induced nausea and vomiting but are reported to improve appetite in patients with AIDS, central pain from multiple sclerosis, and neuropathic pain. The benefits of cannabinoids for cancer pain are mixed. Commercially available cannabinoids are subject to psychotomimetic and addiction (cannabinomimetic) adverse effects largely through activation of the cannabinoid 1 receptor (CB1r). (Source: Journal of Pain and Symptom Management)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Frequency of Infectious Diseases in Immigrants in a Western European Country: A Population-Based Study
Abstract The aim of this population-based study was to assess the incidence rates of infectious diseases in native- (Italian) and foreign-born (immigrants) populations in a North Italy area, in 2006?2010. Crude, age-specific incidence rates (IRs) and age-standardised rate ratios (SRRs) between foreign- and native-born subjects and their 95 % confidence intervals (95 % CI) were estimated. A total of 32,554 cases of infectious diseases were found (9.9 % in foreign-born subjects). The highest SRRs between foreign- and nativeborn subjects were found for tuberculosis (SRR = 27.1; 95 % CI 21.3?34.3), malaria (SRR = 21.1; 14.6?30.4), scabies (SRR = 8.5; 7.6?9.4), AIDS (SRR = 2.5; 1.8?3.4) and viral hepatitis B (SRR = 3.3; 2.1?5.2). The highest IR was found for ...
Qualitative Assessment of HIV Prevention Challenges and Opportunities Among Latino Immigrant Men in a New Receiving City
Abstract Changing demographics in new receiving communities contributes to a lag time between the arrival of new immigrants and the development of appropriate services. This scarcity of services can exacerbate existing disparities in health conditions such as HIV, which disproportionately affects Latinos. Focus groups were conducted in Baltimore with 59 Latino men who had immigrated to the U.S. within the past 10 years to explore the challenges and opportunities to accessing HIV testing and preventative services. Transcripts were analyzed through a modified thematic constant comparison approach. Four thematic categories emerged: information about HIV, HIV fear and stigma, barriers to accessing healthcare, and opportunities for intervention approaches. Information and communicati...
Feasibility of Recruiting Peer Educators to Promote HIV Testing Using Facebook Among Men Who have Sex with Men in Peru
The objective was to explore the feasibility of recruiting and training leaders to deliver a peer intervention via Facebook to promote HIV testing. Training consisted of three sessions focused on HIV epidemiology, consequences of stigma associated with HIV, and ways to use Facebook. We performed pre- and post-training evaluations to assess HIV knowledge and comfort using Facebook. We trained 34 peer leaders. At baseline, the majority of peer leaders were already qualified and knowledgeable about HIV prevention and use of social media. We found a significant increase in proportion of peer leaders who were comfortable using social media to discuss about sexual partners and about STIs. It is feasible to recruit peer leaders who are qualified to conduct a social media based HIV prevention inte...
Prevalence and Frequency of Heterosexual Anal Intercourse Among Young People: A Systematic Review and Meta-analysis
Abstract We aim to assess if heterosexual anal intercourse (AI) is commonly practiced and how frequently it is practiced by young people. We searched PubMed for articles published 1975 to July 2014 reporting data on the proportion of young people (mean age &lt;25) practicing heterosexual AI (AI prevalence) and on number of AI acts (AI frequency). Stratified random-effects meta-analysis and meta-regression were used to produce summary estimates and assess the influence of participant and study characteristics on AI prevalence. Eighty-three and thirteen of the 136 included articles reported data on lifetime AI prevalence and monthly AI frequency, respectively. Estimates were heterogenous. Overall summary estimates of lifetime AI prevalence were 22 % (95 % confidence interval 20?...
Within-Prison Drug Injection among HIV-infected Male Prisoners in Indonesia: A Highly Constrained Choice
Indonesia's HIV epidemic is expanding rapidly. Annual new infections rose 48% from 51,300 to 76,000 between 2008 and 2013, a period when HIV incidence decreased or stabilized in most other Asia-Pacific countries (Joint United Nations Programme on HIV/AIDS, 2013; Ministry of Health, 2008). Despite recent evidence of a transitioning epidemic (National AIDS Commission, 2012), people who inject drugs (PWID) comprise the largest proportion of people living with HIV (PLWH) in Indonesia (Ministry of Health, 2009) and provide a bridge to other high risk groups and the general population (National AIDS Commission, 2012). (Source: Drug and Alcohol Dependence)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Bill Gates predicts HIV vaccine by 2030
Microsoft founder tells Davos that vaccine and new intense drug treatments could end most new cases of deadly virus Continue reading... (Source: Guardian Unlimited Science)
Gates sees 'miracle' tools for AIDS by 2030 in vaccine and drugs
DAVOS, Switzerland (Reuters) - Two new tools to fight AIDS should be available by 2030 in the form of a vaccine and new intense drug treatments, ending most cases of a disease that has killed millions in the past 30 years, Bill Gates said. (Source: Reuters: Health)
Nigeria: Stop HIV Test Before Marriage, Religious Leaders Warned
[Independent (Lagos)]Ado-Ekiti -The Project Manager of Ekiti State Action Committee on AIDS, Doherty Charles Olusegun, has said it's illegal for priests or other religious leaders to mandate prospective couples to go for HIV/AIDs test before marriage. (Source: AllAfrica News: Health and Medicine)
A Randomized Trial to Evaluate the Efficacy of a Web-Based HIV Behavioral Intervention for High-Risk African American Women
Abstract The aim of this study was to develop and test a cost-effective, scalable HIV behavioral intervention for African American women. Eighty-three African American women were recruited from a community health center and randomly assigned to either the web-based Safe Sistah program or to a delayed HIV education control condition. The primary outcome was self-reported condom use. Secondary measures assessed other aspects of the gender-focused training included in Safe Sistah. Participants completed self-report assessments prior to randomization, 1- and 4-months after their program experience. Across the entire study period, women in the experimental condition significantly increased their condom use relative to controls (F = 5.126, p = 0.027). Significant effects were also f...
Knowledge is Power! Increased Provider Knowledge Scores Regarding Pre-exposure Prophylaxis (PrEP) are Associated with Higher Rates of PrEP Prescription and Future Intent to Prescribe PrEP
Abstract The FDA approval of emtricitabine/tenofovir disoproxil fumarate for pre-exposure prophylaxis (PrEP) in 2012 has raised questions about the delivery of PrEP in a real-world setting. iPad-based questionnaires were given to providers at conferences in California and New York to assess knowledge, experience and attitudes regarding PrEP in HIV and non-HIV providers. HIV provider status was defined either by self-identification or by having greater than 5 years of HIV care experience. Knowledge scores were the sum of correct answers from five PrEP knowledge questions. Univariate analyses used t-test to compare knowledge scores and Fisher?s exact test for past or future PrEP prescription between HIV and non-HIV providers. Multivariable linear or logistic regression models wer...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Infant HIV Type 1 gp120 Vaccination Elicits Robust and Durable Anti-V1V2 Immunoglobulin G Responses and Only Rare Envelope-Specific Immunoglobulin A Responses
Conclusion As exemplified by the Chiron vaccine regimen, vaccination of infants against HIV-1 can induce robust, durable Env-specific IgG responses, including anti-V1V2 IgG. (Source: The Journal of Infectious Diseases)
Induction of HIV-1-Specific Mucosal Immune Responses Following Intramuscular Recombinant Adenovirus Serotype 26 HIV-1 Vaccination of Humans
Conclusions These data demonstrate that a single intramuscular administration of this Ad26-vectored HIV-1 Env vaccine elicited both systemic and mucosal immune responses in humans. Induction of antigen-specific humoral and cellular mucosal immunity was not accompanied by a detectable increase in mucosal inflammation. Clinical Trials Registration NCT01103687. (Source: The Journal of Infectious Diseases)
Antibody-Dependent Effector Functions Against HIV Decline in Subjects Receiving Antiretroviral Therapy
Conclusions This longitudinal study showed that cART resulted in significant reductions of HIV-specific effector antibody responses, including ADCC and ADP. Therapeutic vaccines or other immunomodulatory approaches may be required to improve antibody-mediated control of HIV during cART. (Source: The Journal of Infectious Diseases)
Low Bone Mineral Density in Patients With Well-Suppressed HIV Infection: Association With Body Weight, Smoking, and Prior Advanced HIV Disease
Conclusions The observed lower BMD in treated HIV-positive individuals was largely explained by both lower body weight and more smoking. Having experienced symptomatic HIV disease, often associated with weight loss, was another risk factor. The low BMD observed in younger MSM remains unexplained and needs further study. (Source: The Journal of Infectious Diseases)
Modelling Elderly Cardiac Patients Decision Making Using Cognitive Work Analysis: Identifying Requirements for Patient Decision Aids
There is a pressing need for individualized healthcare systems as chronic diseases such as cardiovascular disease (CVD) and diabetics will be responsible for three-quarters of the world's deaths by 2020 [1,2,28]. Most hospital readmission rates are due to a definable set of problems that patients face: poor health, inadequate preparation on discharge, problems with caregivers, non-adherence to instructions regarding diet, medication or fluids, knowledge deficiencies etc., [3?5]. Taken together, the majority of these problems imply a socially important question: ?how can patients be helped to make appropriate decisions on their health and care?? (Source: International Journal of Medical Informatics)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Phenotypic and functional profiles of NK cells exhibiting MMP?mediated CD16 cleavage after anti?HIV antibody?dependent activation
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)
Social support as a protective factor for depression among women caring for children in HIV-endemic South Africa
Abstract Social support has been shown to be a protective resource for mental health among chronically ill adults and caregiver populations. However, to date no known studies have quantitatively explored the relationship between social support and depression among women caring for children in HIV-endemic Southern Africa, although they represent a high risk population for mental health conditions. Using data from a household survey with 2,199 adult female caregivers of children, living in two resource-deprived high HIV-prevalence South African communities, we conducted hierarchical logistic regression analysis with interaction terms to assess whether social support had a main effect or stress-buffering effect on depression. Findings provide evidence of stress-buffering of non-HIV-...
Combination Antiviral Recommended in EU for HIV Treatment Combination Antiviral Recommended in EU for HIV Treatment
A lamivudine/raltegravir combination is expected to ease the daily pill burden for patients with HIV, with efficacy comparable to that of the individual agents. International Approvals (Source: Medscape Medical News Headlines)
Thyroid carcinoma showing thymus-like elements: a clinicopathologic, immunohistochemical, ultrastructural, and molecular analysis.
CONCLUSIONS: GLUT-1 can be used as a novel biomarker for CASTLE, and combined detection of GLUT-1 with CD5 and CD117 aids in the diagnosis of this tumor. Aberrant expression of Bcl-2, p53, p16, E-cadherin, EGFR, C-KIT, and HER-2 may play important roles in the development of CASTLE. PMID: 25596248 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Clinical Significance of First-Trimester Screening of the Retronasal Triangle for Identification of Primary Cleft Palate
Conclusion: The RNT is an important sonographic landmark that has a high sensitivity and specificity for the detection of OC in the first trimester. 3D ultrasound is an important tool that aids in confirming diagnosis of OC in the first and second trimesters.Fetal Diagn Ther (Source: Fetal Diagnosis and Therapy)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Sonar Technology Aids People with Vision Disabilities
When a biologist who studies bats and a computer scientist cross paths, amazingly cool things can happen. Cool things such as a sonar device to assist people with vision disabilities. (Source: Disabled World)
Africa: Ahead of the African Union Summit, New Champions Join Efforts for an Aids-Free Generation in Africa
[UNAIDS]Gaborone -Today, the Champions for an AIDS-Free Generation (Champions) announced that four leaders are joining their distinguished ranks. The new Champions are: Kgalema Motlanthe, former President of South Africa; Joyce Banda, former President of Malawi; Alpha Oumar Konaré, former President of Mali; and Olusegun Obasanjo, former President of Nigeria. (Source: AllAfrica News: Health and Medicine)
Effects of Anti-Inflammatory Drugs on Intravenous Immunoglobulin Therapy in the Acute Phase of Kawasaki Disease
Abstract This retrospective study aimed to investigate the effects of anti-inflammatory drugs (ADs) on intravenous immunoglobulin (IVIG) therapy in the acute phase of Kawasaki disease. In total, 182 pediatric patients who received IVIG therapy for Kawasaki disease between 1999 and 2013 at the Department of Pediatrics, Aomori Prefectural Central Hospital were enrolled. Patients were divided into 2 groups: an S group, including 111 patients who received single IVIG therapy with delayed administration of ADs, and a T group, including 71 patients who received concomitant AIDs with IVIG. During the study, the only ADs administered were aspirin (A: 30 mg/kg/day) or flurbiprofen (F: 3?5 mg/kg/day). Steroids were not administered to any patient. The regimen of the S group was partial...
Nigeria: UNAIDS - Nigeria to Commence Production of Anti-Retroviral Drugs
[This Day]The UNAIDS Country Director, Dr. Bilali Camara, on Thursday said four companies will commence production of anti-retroviral drugs in Nigeria. Camara, who is also the UNAIDS Focal Point for ECOWAS, disclosed this in an interview with newsmen in Abuja. (Source: AllAfrica News: HIV-Aids and STDs)
Namibia: One Person Cannot Easily Spread HIV Wilfully
[Namibian]RECENT media reports concerning the alleged wilful transmission of HIV in Namibia need to be contested and shot down before they are considered credible. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Nigeria: Nigeria to Commence Production of Anti-Retroviral Drugs - UNAIDS
[Vanguard]Dr Bilali Camara, UNAIDS Country Director, said on Thursday that four companies will commence production of anti-retroviral drugs in Nigeria. (Source: AllAfrica News: HIV-Aids and STDs)
Participation in research as a means of improving quality of care: the role of a principal investigator in multicentre clinical trials
Key content A doctor?s duty to reduce uncertainty in the provision of care requires their participation in well?developed and ethically approved clinical trials. Compared to non?participation, collaboration in a clinical trial improves the quality of care of women. Successful recruitment into multicentre trials is achieved through enthusiastic involvement of several principal investigators (PIs). Allocation of NHS patient care costs for clinical research supports those engaged in recruiting women into studies. Consultants need to acquire basic mandatory research training for the role as a PI leading research. An awareness of support mechanisms locally, regionally and nationally, such as NIHR Clinical Research Network, aids in the execution of PI duties. PI contribution to re...
Pott's Disease? AIDS-Associated Mycobacterium heckeshornense Spinal Osteomyelitis and Diskitis [Case Reports]
We present a case of aggressive spinal osteomyelitis caused by Mycobacterium heckeshornense in an AIDS patient; a review of the literature is also included. (Source: Journal of Clinical Microbiology)
Citrinin detection using phage-displayed anti-idiotypic single-domain antibody for antigen mimicry
In conclusion, the proposed P-ELISA demonstrates the potential use of phage-displayed anti-idiotypic VHH as surrogate for small molecules and signal-amplification carrier to improve assay performance for more sensitive analyte detection in food safety monitoring. (Source: Food Chemistry)
Differential Regulation of NF-?B-Mediated Proviral and Antiviral Host Gene Expression by Primate Lentiviral Nef and Vpu Proteins
Publication date: Available online 22 January 2015 Source:Cell Reports Author(s): Daniel Sauter , Dominik Hotter , Benoît Van Driessche , Christina M. Stürzel , Silvia F. Kluge , Steffen Wildum , Hangxing Yu , Bernd Baumann , Thomas Wirth , Jean-Christophe Plantier , Marie Leoz , Beatrice H. Hahn , Carine Van Lint , Frank Kirchhoff NF-?B is essential for effective transcription of primate lentiviral genomes and also activates antiviral host genes. Here, we show that the early protein Nef of most primate lentiviruses enhances NF-?B activation. In contrast, the late protein Vpu of HIV-1 and its simian precursors inhibits activation of NF-?B, even in the presence of Nef. Although this effect of Vpu did not correlate with its ability to interact with ?-TrCP, it involved the stabi...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Temporal Trends in Age at HIV Diagnosis in Cohorts in the United States, the Caribbean, and Central and South America
Abstract In the United States (USA), the age of those newly diagnosed with HIV is changing, particularly among men who have sex with men (MSM). A retrospective analysis included HIV-infected adults from seven sites in the Caribbean, Central and South America network (CCASAnet) and the Vanderbilt Comprehensive Care Clinic (VCCC-Nashville, Tennessee, USA). We estimated the proportion of patients &lt;25 years at HIV diagnosis by calendar year among the general population and MSM. 19,466 (CCASAnet) and 3,746 (VCCC) patients were included. The proportion &lt;25 years at diagnosis in VCCC increased over time for both the general population and MSM (p &lt; 0.001). Only in the Chilean site for the general population and the Brazilian site for MSM were similar trends seen. Subjects &lt...
Place of Residence Moderates the Relationship Between Emotional Closeness and Syringe Sharing Among Injection Drug Using Clients of Sex Workers in the US-Mexico Border Region
Abstract Injection drug-using men from the US and Mexico who purchase sex in Tijuana, Mexico are at risk for transmitting HIV to their contacts in both countries via syringe sharing. We used social network methods to understand whether place of residence (US vs. Mexico) moderated the effect of emotional closeness on syringe sharing. We interviewed 199 drug-using men who reported paying/trading for sex in Tijuana, Mexico using an epidemiological and social network survey and collected samples for HIV/STI testing. Seventy-two men reported using injection drugs with 272 network contacts. Emotional closeness was strongly associated with syringe sharing in relationship where the partner lives in the US, while the relationship between emotional closeness and syringe sharing was cons...
Comprehensive Evaluation of Caregiver-Reported Antiretroviral Therapy Adherence for HIV-Infected Children
Abstract For HIV-infected children, adherence to antiretroviral therapy (ART) is often assessed by caregiver report but there are few data on their validity. We conducted prospective evaluations with 191 children ages 0?14 years and their caregivers over 6 months in western Kenya to identify questionnaire items that best predicted adherence to ART. Medication Event Monitoring Systems® (MEMS, MWV/AARDEX Ltd., Switzerland) electronic dose monitors were used as external criterion for adherence. We employed a novel variable selection tool using the LASSO technique with logistic regression to identify items best correlated with dichotomized MEMS adherence (?90 or &lt;90 % doses taken). Nine of 48 adherence items were identified as the best predictors of adherence, including mis...
The Interaction Between Sickle Cell Disease and HIV Infection: A Systematic Review
Human immunodeficiency virus (HIV) and sickle cell disease (SCD) are regarded as endemic in overlapping geographic areas; however, for most countries only scarce data on the interaction between HIV and SCD and disease burden exist. HIV prevalence in SCD patients varies between 0% and 11.5% in published studies. SCD has been suggested to reduce disease progression of HIV into AIDS. Various interactions of antiretroviral therapy with SCD exist. Both SCD and HIV act as common risk factors for stroke, avascular necrosis, severe splenic dysfunction, pulmonary arterial hypertension, and sepsis, which may result in synergistic increase in risk of developing these diseases. No treatment guidelines regarding SCD with HIV coinfection were identified. Available evidence is mainly based on small clini...
Comparison of Risk and Age at Diagnosis of Myocardial Infarction, End-Stage Renal Disease, and Non-AIDS-Defining Cancer in HIV-Infected Versus Uninfected Adults
Conclusions.&nbsp;HIV-infected adults had a higher risk of these age-associated events, but they occurred at similar ages than those without HIV. (Source: Clinical Infectious Diseases)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Long-term Protection From Isoniazid Preventive Therapy for Tuberculosis in HIV-Infected Patients in a Medium-Burden Tuberculosis Setting: The TB/HIV in Rio (THRio) Study
Conclusions.&nbsp;Isoniazid preventive therapy significantly reduced tuberculosis risk among HIV-infected patients with a positive TST. In a medium-prevalence setting, 6 months of isoniazid in HIV-infected patients with positive TST reduces tuberculosis risk over 7 years of follow-up, in contrast to results of studies in higher-burden settings in Africa. (Source: Clinical Infectious Diseases)
The Association Between APOL1 Risk Alleles and Longitudinal Kidney Function Differs by HIV Viral Suppression Status
Conclusions.&nbsp;Unsuppressed HIV-infected African Americans with the APOL1 high-risk genotype experience an accelerated rate of kidney function decline; HIV suppression with antiretroviral therapy may reduce these deleterious renal effects. (Source: Clinical Infectious Diseases)
A Single Dose of Benzathine Penicillin G Is as Effective as Multiple Doses of Benzathine Penicillin G for the Treatment of HIV-Infected Persons With Early Syphilis
Conclusions.&nbsp;In this cohort, additional BPG doses did not affect treatment response. Our data support the current recommendations for the use of a single dose of BPG to treat HIV-infected persons with early syphilis. (Source: Clinical Infectious Diseases)
Editorial Commentary: The Optimal Dose of Penicillin When Treating Syphilis in HIV-Infected Persons: Enough, Already?
(Source: Clinical Infectious Diseases)
Gastrointestinal surgery and the acquired immune deficiency syndrome
This article questions whether gastrointestinal surgical procedures can be safe and effective therapeutic measures in HIV/AIDS patients and if surgical outcome is worthy of the surgeon?s ethical responsibility to treat. As HIV/AIDS patients are not a homogenous group, with careful patient selection, emergency laparotomy for peritonitis confers worthwhile palliation. However, aggressive surgical intervention must be undertaken with caution and adequate peri-operative care is required. Symptomatic improvement of anorectal pathology may make delayed wound healing an acceptable complication. Alternatives to surgery can be contemplated for diagnosis, prophylaxis or palliation. (Source: Annals of Medicine and Surgery)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Children seeking refuge: A review of the escalating humanitarian crisis of child sexual abuse and HIV/AIDS in Latin America
Early identification and intervention for victims of child sexual abuse (CSA) is essential to halting the spread of HIV in Latino populations because children who are sexually abused are at an increased risk of contracting HIV. The recent influx of unaccompanied children into the Unites States exposed histories of victimization, vulnerability to CSA, and suggested an epidemic of CSA in Latin America. CSA has been identified as a contributory event to HIV infection. The aim of our research was to identify factors associated with CSA and Latin Americans. (Source: Journal of the Association of Nurses in AIDS Care)
Coping with stress strategies in HIV-infected Iranian patients
Stress has significant adverse impacts on health outcomes of HIV-infected patients. Our study explored coping with stress strategies by HIV-infected Iranian patients. A qualitative content analysis study was conducted at the Consultation Clinic of HIV at the Imam Khomeini Hospital in Tehran, Iran, in 2012. Twenty-six semi-structured in-depth interviews were done. Participants were asked about coping strategies for stress. After the first interview, continuous analysis of data was started and continued up to data saturation. (Source: Journal of the Association of Nurses in AIDS Care)
Evaluation of the Wii Balance Board for Walking Aids Prediction: Proof-of-Concept Study in Total Knee Arthroplasty
Conclusions The WBB was able to provide quantitative measures of standing balance which could assist healthcare professionals in prescribing the appropriate type of walking aids for patients. Further investigation is needed to assess whether using the WBB could lead to meaningful changes in clinical outcomes such as falls. (Source: PLoS One)
Funding Announcement PS15-1505: Enhancing HIV Prevention Communication and Mobilization Efforts Through Strategic Partnerships
The purpose of this FOA is (1) to support the dissemination of Act Against AIDS (AAA) campaign materials, messaging and other CDC resources that support HIV prevention and (2) to implement national engagement efforts focusing on HIV prevention and awareness. (Source: CDC HIV/AIDS Prevention)
NLM HIV/AIDS Portal Now Offers Multilingual Content Search
NLM?s HIV/AIDS Portal now offers the ability to search for multilingual content. The new Multilingual Search interface searches specifically for HIV/AIDS related topics from the multilingual and multicultural content of HealthReach (formerly RHIN). HealthReach offers easy access to quality health information to individuals for whom English is not the primary language. It is also an [&#8230;] (Source: NN/LM Middle Atlantic Region Blog)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Africa: Child Deaths Will Go Down, and More Diseases Will be Wiped Out
[Gates Foundation]Until recently, the world was split in two. (Source: AllAfrica News: HIV-Aids and STDs)
Ethiopia: Coffee Ceremony Used to Educate On HIV
[Key Correspondents]Coffee ceremony is a tradition in Ethiopia, where the world's most famous coffee Coffea Arabica grows. The ceremony takes about an hour and helps strengthen bonds within the community. (Source: AllAfrica News: HIV-Aids and STDs)
Zimbabwe: Buying 'Airtime' With Antiretroviral Pills
[Waza]Many Zimbabwean HIV-positive youngsters face discrimination and stigmatisation on a daily basis. Evelyn Honde (16) is one of them. (Source: AllAfrica News: HIV-Aids and STDs)
Zimbabwe: Government Warns Churches Over HIV Cure Claims
[New Zimbabwe]THE government has warned churches led by so-called prophets against deceiving people on antiretroviral therapy that they can cure HIV/AIDS saying this could result in unnecessary loss of life when they stop taking their medication. (Source: AllAfrica News: HIV-Aids and STDs)
Stigma against HIV/AIDS among female sex workers and general migrant women in eastern China
Conclusions: The present study suggests that there is an urgent need for the development of appropriate education strategies to reduce HIV related stigma among FSW and GMW in Shanghai, China. In particular, older women, less educated women, and women that have lived in Shanghai a relatively long time should be targeted in future stigma reduction programs. (Source: BMC Women's Health)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Be SMART: examining the experience of implementing the NHS Health Check in UK primary care
Conclusions: HCPs? training needs to include the use and evidence of the effectiveness of SMART goals in changing health behaviours. The significance of fidelity to protocol needs to be communicated to HCPs and commissioners to ensure consistency. Monitoring and measurement of follow-up, e.g., tracking of referrals, need to be resourced to provide evidence of the success of the NHS Health Check in terms of healthier lifestyles and reduced CVD risk. (Source: BMC Family Practice)
A robust real-time gait event detection using wireless gyroscope and its application on normal and altered gaits
Gait events detection allows clinicians and biomechanics researchers to determine timing of gait events, to estimate duration of stance phase and swing phase and to segment gait data. It also aids biomedical engineers to improve the design of orthoses and FES (functional electrical stimulation) systems. In recent years, researchers have resorted to using gyroscopes to determine heel-strike (HS) and toe-off (TO) events in gait cycles. However, these methods are subjected to significant delays when implemented in real-time gait monitoring devices, orthoses, and FES systems. (Source: Medical Engineering and Physics)
Using the Pathogenic and Nonpathogenic Nonhuman Primate Model for Studying Non-AIDS Comorbidities
Abstract With the advent of antiretroviral therapy that can control virus replication below the detection levels of conventional assays, a new clinical landscape of AIDS emerged, in which non-AIDS complications prevail over AIDS-defining conditions. These comorbidities are diverse and affect multiple organs, thus resulting in cardiovascular, kidney, neurocognitive and liver disease, osteopenia/osteoporosis, and cancers. A common feature of these conditions is that they are generally associated with accelerated aging. The mechanism behind these comorbidities is chronic excessive inflammation induced by HIV infection, which persists under antiretroviral therapy. Progressive simian immunodeficiency virus (SIV) infection of nonhuman primates (NHPs) closely reproduces these comorbiditi...
Neuropathogenesis of HIV: From Initial Neuroinvasion to HIV-Associated Neurocognitive Disorder (HAND)
Abstract Early in the HIV epidemic, the central nervous system (CNS) was recognized as a target of infection and injury in the advanced stages of disease. Though the most severe forms of HIV-associated neurocognitive disorder (HAND) related to severe immunosuppression are rare in the current era of widespread combination antiretroviral therapy (cART), evidence now supports pathological involvement of the CNS throughout the course of infection. Recent work suggests that the stage for HIV neuropathogenesis may be set with initial viral entry into the CNS, followed by initiation of pathogenetic processes including neuroinflammation and neurotoxicity, and establishment of local, compartmentalized HIV replication that may reflect a tissue reservoir for HIV. Key questions still exist as...
Cellulose-based filter aids increase the capacity of depth filters during the downstream processing of plant-derived biopharmaceutical proteins.
Authors: Buyel JF, Opdensteinen P, Fischer R Abstract Downstream processing (DSP) is a major cost factor during the production of biopharmaceutical proteins. Clarification can account for ?40% of these costs, especially when a large amount of dispersed particulate material is generated, such as during the extraction of intracellular proteins from plants. Filter capacity can be increased (and DSP costs reduced) by using flocculants. Here we show that cellulose-based filter aids can enhance the positive effect of flocculants by improving depth filter capacity even further. A design-of-experiments (DoE) approach was used to identify the optimal size and concentration of filter aids, at different values of pH and conductivity, for the clarification of tobacco leaf extracts during the...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Longitudinal and cross sectional assessments of health utility in adults with HIV/AIDS: a systematic review and meta-analysis
Conclusion: The study provides an accumulation of evidence on measurement properties of health utility estimates that can help inform the selection of instruments for future studies. The pooled estimates of health utilities and their trends are useful in economic evaluation and policy modelling of HIV/AIDS treatment strategies. (Source: BMC Health Services Research)
Prioritization of New Oral Hepatitis C Therapies for HIV Patients.
Authors: Barreiro P, Fernández-Montero JV, Soriano V Abstract Access to antiretroviral therapy prevents progression of immunodeficiency and development of opportunistic cancers and infections in HIV-infected persons. However, the virus cannot be eliminated and lifelong HIV treatment is needed. For this reason, tolerance and side effects have become an important consideration when choosing HIV drugs. Integrase inhibitors (i.e. dolutegravir) and nonnucleoside analogues (i.e. rilpivirine) are the preferred third agents to be used along with a nucleos(t)ide analogue backbone, either abacavir/lamivudine or tenofovir/emtricitabine. Single-tablet regimens with three agents are currently available and significantly improve HIV treatment adherence. In contrast, HIV protease inhibitors are ...
HIV Tropism Shift: New Paradigm on Cell Therapy Strategies for HIV Cure.
Authors: Poveda E Abstract CCR5 and CXCR4 are the main cellular coreceptors involved in the entry of HIV-1 into the host cells. Certain individuals possess a 32 base pair deletion in the CCR5 allele (CCR5 delta32), which produces a truncated form of this coreceptor associated with a natural resistance to HIV infection when this appears in homozygosis. These findings have inspired the design of anti-HIV drugs, such as the CCR5 antagonists (i.e. maraviroc), which block the interaction between the virus and the CCR5 coreceptor inhibiting viral entry. PMID: 25608470 [PubMed - as supplied by publisher] (Source: AIDS Reviews)
Non-healing genital herpes mimicking donovanosis in an immunocompetent man.
We report a case of genital herpes manifesting as painless chronic non-healing genital ulcers with exuberant granulation tissue in an immunocompetent man. Owing to this morphology, the ulcers were initially mistaken for donovanosis. To the best of our knowledge, such a presentation of genital herpes in an immunocompetent individual has not been described previously. PMID: 25614521 [PubMed - as supplied by publisher] (Source: Herpes)
Demedicalizing AIDS Prevention and Treatment in Africa
New England Journal of Medicine, Volume 372, Issue 4, Page 303-305, January 2015. (Source: New England Journal of Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Comprehensiveness and programmatic vulnerability to stds/hiv/aids in primary care
This study aimed to identify programmatic vulnerability to STDs/HIV/AIDS in primary health centers (PHCs). This is a descrip - tive and quantitative study carried out in the city of São Paulo. An online survey was applied (FormSUS platform), involving administrators from 442 PHCs in the city, with responses received from 328 of them (74.2%), of which 53.6% were nurses. At - tention was raised in relation to program - matic vulnerability in the PHCs regarding certain items of infrastructure, prevention, treatment, prenatal care and integration among services on STDs/HIV/AIDS care. It was concluded that in order to reach comprehensiveness of actions for HIV/ AIDS in primary health care, it is necessary to consider programmatic vulnerability, in a...
Malawi: When Hours Turn to Days - a Ridiculed HIV Woman Stands Strong
[Key Correspondents]To her, the decision to test for HIV was a forced one. Forced by the fact her husband left her because she was growing thin, always feeling tired and occasionally falling sick. (Source: AllAfrica News: HIV-Aids and STDs)
Zimbabwe: 126 Million Additional Funding Announced to Fight HIV in Zimbabwe
[UNDP]New York City - A new agreement reached in Zimbabwe by the UN Development Programme (UNDP) and the Global Fund to Fight AIDS, Tuberculosis and Malaria is set to provide a major boost in the fight against HIV and AIDs in the country, which is among the hardest hit by the virus in sub-Saharan Africa. (Source: AllAfrica News: HIV-Aids and STDs)
The Western Africa Ebola Virus Disease Epidemic Exhibits Both Global Exponential and Local Polynomial Growth Rates
Discussion We have shown that the cumulative number of EVD cases in a number of administrative areas of Guinea, Sierra Leone and Liberia is best approximated by polynomial rather than exponential growth over several generations of EVD. This pattern is also true of the initial diffusion of the West African EVD epidemic, particularly in Gueckedou district, Guinea, where a super-spreading event linked to burial rituals facilitated onward transmission in December 2013. Transmission progressed unchecked for several generations in Gueckedou, as the World Health Organization did not receive notification of the outbreak until March 23rd, 201418. In contrast, when data are aggregated nationally, or across the broader West Africa region, total case counts show periods of approximate exponential grow...
WHO welcomes appointment of UN Special Envoy on Tuberculosis Dr Eric P. Goosby
WHO welcomes the appointment of the new United Nations Secretary-General?s Special Envoy on Tuberculosis (TB), Dr Eric P. Goosby, M.D. Dr Goosby?s extensive and high-level experience in global health and diplomacy give him the perfect background for this critical role. Despite recent gains, tuberculosis remains a serious public health issue - fueled in part by the HIV/AIDS epidemic, with antimicrobial resistance posing an ever-present threat to its control. WHO looks forward to working closely with Dr Goosby in our shared effort to raise the profile of the fight against TB and to attain the ambitious new targets agreed at last year?s World Health Assembly. (Source: WHO news)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Nigeria: People Living With HIV Caution Members On Abalaka's Vaccine
[Independent (Lagos)]The Network of People Living With HIV/AIDS in Nigeria (NEPWHAN) has warn its members not to be lured into patronising Dr Jeremiah Abalaka's vaccine, saying currently, there is no known cure for the virus. (Source: AllAfrica News: HIV-Aids and STDs)
Uganda: High Hopes Ahead of Microbicide Trial Results
[Observer]HIV/Aids researchers are anticipating positive results from a large-scale trial assessing the efficacy of a vaginal microbicide gel in preventing HIV infection in women. (Source: AllAfrica News: HIV-Aids and STDs)
New Considerations in HIV Care DiagnosticsNew Considerations in HIV Care Diagnostics
Dr Benjamin Young highlights the recently announced UNAIDS Fast-track Cities program and reviews two new studies on HIV diagnostics. Medscape HIV/AIDS (Source: Medscape Hiv-Aids Headlines)
Political factors behind US global AIDS programmes slow-down
Publication date: Available online 21 January 2015 Source:The Lancet Author(s): Matthew M Kavanagh , Jamila Headley , Asia Russell (Source: The Lancet)
Estimation of changes in maternal mortality in a rural district of northern Tanzania during the last 50 years
ConclusionsDuring the last 50 years we have witnessed a reduction of maternal mortality and improvements in maternal health. Progress has been made towards improving Millennium Development Goals 5 although only a prospective population?based survey will provide the ultimate answer.This article is protected by copyright. All rights reserved. (Source: Acta Obstetricia et Gynecologica Scandinavica)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Program synergies and social relations: implications of integrating HIV testing and counselling into maternal health care on care seeking
Conclusion: While providers and pregnant women view program synergies from integrating HIV services into antenatal care positively, lack of supportive provider-patient relationships, lack of trust resulting from harsh treatment or breaches in confidentiality, and stigma still inhibit women?s care seeking. As countries continue rollout of Option B+, social relations between patients and providers must be understood and addressed to ensure that integrated delivery of HIV counselling and services encourages women?s care seeking in order to improve maternal and child health. (Source: BMC Public Health)
Delaying initiation of ART for 5 weeks improves survival in patients with HIV infection with cyrptococcal meningitis
Commentary on: Boulware DR, Meya DB, Muzoora C, et al.. Timing of antiretroviral therapy after diagnosis of cryptococcal meningitis. N Engl J Med 2014;370:2487&ndash;98. Context Cryptococcal meningitis (CM) is a major cause of mortality for individuals with HIV infection in Africa. Early initiation of antiretroviral therapy (ART) has been shown to decrease mortality in a number of opportunistic infections such as tuberculosis (TB) and Pneumocystis jirovicii pneumonia, but may increase mortality in central nervous system-related opportunistic infections such as TB meningitis.1 The timing of ART however remains controversial for CM.2 3 Methods The study by Bouleware and colleagues is a randomised trial that assigned 177 HIV-infected ART-na&iuml;ve patients from Uganda and South Africa who we...
A study of the clinical and radiological features in a cohort of 93 patients with a COL2A1 mutation causing spondyloepiphyseal dysplasia congenita or a related phenotype
Type 2 collagen disorders encompass a diverse group of skeletal dysplasias that are commonly associated with orthopedic, ocular, and hearing problems. However, the frequency of many clinical features has never been determined. We retrospectively investigated the clinical, radiological, and genotypic data in a group of 93 patients with molecularly confirmed SEDC or a related disorder. The majority of the patients (80/93) had short stature, with radiological features of SEDC (n?=?64), others having SEMD (n?=?5), Kniest dysplasia (n?=?7), spondyloperipheral dysplasia (n?=?2), or Torrance?like dysplasia (n?=?2). The remaining 13 patients had normal stature with mild SED, Stickler?like syndrome or multiple epiphyseal dysplasia. Over 50% of the patients had undergone orth...
Highlights from this issue
As memories of the festive season fade, many clinicians will recall recent patients who regret alcohol related sexual encounters. Alcohol has a complicated role in sexual cultures of the West, and perhaps an even more complicated place in settings where it is banned or hard to access. As a student visiting friends working in Norway, I was astonished to visit a home that had its own still, producing a potato liqueur behind locked cellar doors. Alcohol in the UK is relatively cheap, and home production of spirits (with the attendant risk of methanol poisoning) almost unheard of. The role of alcohol in sexual risk is complex and disputed. On the one hand, alcohol has been used through the ages to facilitate and ease planned and low risk sexual encounters. On the other, it may increase the lik...
The BASHH HIV Special Interest Group (SIG)
As the previous and current chair of the British Association for Sexual Health and HIV (BASHH) HIV Special Interest Group (SIG), we will summarise the activities of this busy, diverse SIG. We have about 20 members who communicate regularly by email and include trainee, community, nursing and pharmacy representation. The &lsquo;HIV SIG&rsquo; is also involved in activities related to hepatitis B and C, working closely with the British HIV Association (BHIVA) hepatitis subgroup and other relevant organisations. Our main role is to provide HIV and hepatitis-related Continuing Professional Development (CPD) for BASHH members, an activity fulfilled primarily by the annual BASHH HIV Masterclass. This non-London meeting is held over 2&nbsp;days and attracts a broad spectrum of care professionals,...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Comparison of risk factors in HIV-infected men who have sex with men, coinfected or not with hepatitis C virus (ANRS VESPA2 French cross-sectional national survey)
Conclusions HIV-MSM reporting several sexual risk factors should be sensitised to risk-reduction behaviours to avoid HCV transmission to sexual partners, and infection or reinfection with HCV. (Source: Sexually Transmitted Infections)
Internet-based cohort study of HIV testing over 1 year among men who have sex with men living in England and exposed to a social marketing intervention promoting testing
Conclusions This social marketing intervention was not associated with increased rates of HIV testing. More effective promotion of HIV testing is needed among MSM in England to reduce the average duration of undiagnosed infection. (Source: Sexually Transmitted Infections)
Drug use, sexual risk behaviour and sexually transmitted infections among swingers: a cross-sectional study in The Netherlands
Conclusions High rates of multiple drug use, as well as risky sexual behaviour and STIs among swingers, warrant paying more attention to this key population in prevention and care, as they are a risk group that is generally under-recognised and underserved in care. (Source: Sexually Transmitted Infections)
A cross-sectional survey exploring attitudes towards provincial electronic health record implementation among clients attending the Provincial Sexually Transmitted Infections Clinic in British Columbia
Discussion While most participants thought an EHR was acceptable, a large minority expressed that they might avoid testing if their records were made part of a provincial EHR. The introduction of a provincial EHR should be considered with caution in STI healthcare settings to ensure that screening, case detection and treatment are not negatively impacted. (Source: Sexually Transmitted Infections)
Self-reported STIs and sexual health checks in a cross-sectional study of gay and bisexual men in New Zealand
Conclusions STIs are commonly reported in this community sample of MSM but will underestimate the true incidence due to asymptomatic infection. Screening for STIs outside sexual health clinics should be normalised for MSM and made accessible, safe and relevant. (Source: Sexually Transmitted Infections)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
After Venus, mercury: syphilis treatment in the UK before Salvarsan
At the beginning of the twentieth century, the treatment of syphilis varied substantially in the UK. Two of the commonly used treatments&mdash;mercury and bismuth&mdash;were often used for long durations, which prompted the public health warning, &lsquo;two minutes with Venus, two years with mercury&rsquo;.1 Beyond this variation in treatment, venereology itself was a topic taught to generalists rather than specialists.2 Moral condemnation attached to those with syphilis, whose illness was often considered self-inflicted. Patients themselves, fearful of public scrutiny and stigma, often turned to quacks rather than face public clinics. Because UK hospitals refused to treat diseases considered to be self-inflicted, venereal diseases such as syphilis were excluded from the National Health In...
Magic bullet: Paul Ehrlich, Salvarsan and the birth of venereology
In the years following its discovery, Salvarsan would have impacts far beyond that of syphilis treatment alone. Salvarsan's expansion would eventually reshape the broader landscape of venereal disease service delivery in the UK. In August 1913, Paul Ehrlich presented at the International Medical Congress in London,1 where he dazzled the medical community with his new cure.2 Prompted by the novelty of Ehrlich's magic bullet, Parliament passed a resolution enacting a new Royal Commission on Venereal Diseases charged with directing venereal disease (VD) policy in the UK. The new commissioners stated that &lsquo;there are good grounds for concluding that eradication of the spirochaete with complete cure, or a total absence of subsequent signs or symptoms of the disease in the majority of cases...
The magic bullet hits many targets: Salvarsan's impact on UK health systems, 1909-1943
The development of Salvarsan had a profound impact on venereal disease (VD) care in the UK. Administratively distinct from the general health system, the new system of VD care created by the Royal Commission provided diagnosis and treatment to all regardless of means. The government supplied three-quarters of the centres&rsquo; costs and provided Salvarsan free to general practitioners.1 Beyond shaping health systems, the growing importance of Salvarsan also prompted the creation of a new medical subspecialty: venereology, which emerged with its own specialist training track focused on diagnosing, treating and eventually preventing syphilis infection. By the end of 1917, 118 new VD clinics had opened and 204&nbsp;000 patients were evaluated.2 Syphilis screening increased after the developm...
A cure at last? Penicillin's unintended consequences on syphilis control, 1944-1964
In 1928, Alexander Fleming discovered the mould Penicillum notatum,1 setting the stage for the development of an entirely new syphilis cure. Initial problems with cultivation and isolation waylaid the research until it was taken on by the Oxford team of Howard Florey and Ernst Boris Chain.2 The first patient was treated in 1943 and within 12&nbsp;months over 10&nbsp;000 early syphilis patients had been treated.3 Several features of penicillin made its development significant. Unlike Salvarsan's, penicillin's organic effects were clear-cut and dramatic. As Salvarsan had shaped venereal disease control in the UK, the rollout of penicillin also transformed healthcare systems. The widespread use of penicillin was a major force behind historic decreases in reported syphilis cases. There was a 9...
The impact of penicillin on sexual healthcare delivery systems in mid-20th century Britain
Penicillin's introduction in 1943 as a simple, inexpensive cure for syphilis had notable influences on venereology and broader sexual healthcare systems. Foremost among these was the perception that venereal disease (VD) no longer posed a threat and therefore merited fewer resources for control. As the chairman of a regional hospital board replied, when asked about reconstructing a VD clinic in 1958: "We don't want to spend money on these dying diseases".1 While venereology had developed as a specialty in part because of Salvarsan, general practitioners could easily provide penicillin to patients. Thus, penicillin's success left some venereologists reflecting that they had worked themselves out of a profession. One noted:The British venereologist... may perhaps be compared with the fighter...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Cigarette Users' Interest in Using or Switching to Electronic Nicotine Delivery Systems for Smokeless Tobacco for Harm Reduction, Cessation, or Novelty: A Cross-Sectional Survey of US Adults
Conclusions: This study highlights higher interest in ENDS versus smokeless tobacco and greater interest in both for harm reduction and cessation than due to novelty or smoking restrictions. Developing educational campaigns and informing practitioners about caveats around ENDS as cessation or harm reduction aids are critical. (Source: Nicotine and Tobacco Research)
Treatment initiation factors and cognitive outcome in youth with perinatally acquired HIV infection
ConclusionsEarlier age at HAART initiation and higher CPE score of a regimen did not improve cognitive outcomes. However, initiating HAART prior to AIDS protected against AIDS and was associated with a significantly higher FSIQ. (Source: HIV Medicine)
[Ecthyma gangrenosum associated with infection involving a methicillin-sensitive, Panton-Valentine-negative strain of Staphylococcus aureus.]
In this report, we present an extremely rare case of an EG caused by methicillin-sensitive Staphylococcus aureus (MSSA) infection. This case, highly characteristic of EG both clinically and histologically, calls into question the physiopathological mechanisms of the disease and provides a reminder that it may be caused by a variety of organisms. PATIENTS AND METHODS: A 62-year-old woman, followed for HIV seropositivity at the AIDS stage, developed a painful purpuric skin rash evolving towards necrotic nodules characteristic of ecthyma gangrenosum. Skin biopsy confirmed the diagnosis of EG due to methicillin-sensitive S. aureus (MSSA) infection without toxins or bacteraemia. DISCUSSION: To the best of our knowledge, this is the first case in the literature in which MSSA is reported...
OHSU's Louis Picker homes in on HIV's hidden sanctuary
Dr. Louis Picker, the Oregon Health & Science University scientist who is working on an HIV vaccine, has reached a breakthrough an another front in the battle against AIDS. While Picker's previous research centered on preventive vaccines that could be given to healthy people, this latest research takes aim at finding a cure for those already infected. It's a much tougher challenge, he said. "What we've identified is a barrier to a cure that needs to be overcome," said Picker, associate director? (Source: bizjournals.com Health Care:Biotechnology headlines)
Understanding the relationship between walking aids and falls in older adults: a prospective cohort study - Roman de Mettelinge T, Cambier D.
BACKGROUND:: A substantial proportion of older adults living in residential aged care facilities are use wheelchairs or walk with aids. The relationship between using walking aids and falling is somewhat inconsistent and poorly understood. PURPOSE:... (Source: SafetyLit: All (Unduplicated))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Ghana: UNAIDS and Partners Use Afcon 2015 to Promote the 'Protect the Goal' Campaign
[Ghana Govt.]According to the 2013 Global AIDS Program (GAP) Report of the United Nations Program on HIV/AIDS (UNAIDS), sub-Saharan Africa alone hosts 24.7 million of the world's 35 million people living with Human Immunodeficiency Virus (HIV) including 2.1 million new infections, the youth being the most-affected. (Source: AllAfrica News: Health and Medicine)
Social Factors Tied To Risk for Detectable HIV in PregnancySocial Factors Tied To Risk for Detectable HIV in Pregnancy
Even with HAART, socially disadvantaged women are at higher risk for detectable HIV at delivery during a first pregnancy, a new study suggests. Medscape Medical News (Source: Medscape Hiv-Aids Headlines)
Assessing the Discriminant Ability, Reliability, and Comparability of Multiple Short Forms of the Boston Naming Test in an Alzheimer's Disease Center Cohort
Conclusions: With the notable exception of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) 15-item BNT, short forms were internally consistent and highly correlated with the full version; these measures varied by diagnosis and generally improved from normal to mild cognitive impairment (MCI) to dementia. All short forms retained the ability to discriminate between normal subjects and those with dementia. The ability to discriminate between normal and MCI subjects was less strong for the short forms than the full BNT, but they exhibited similar patterns. These results have important implications for researchers designing longitudinal studies, who must consider that the statistical properties of even closely related test forms may be quite different.Dement Geriatr Cogn...
Review of Otorrhea Microbiology: Is There a Pathogenic Role of Corynebacter?
Conclusion: Corynebacterium spp. may be underestimated in their potential to cause clinically significant otologic infections. Our results indicate a potential need for expanding surveillance for Corynebacterium spp. (Source: Otology and Neurotology)
Cameroon: CAPEC Fighting to Alleviate the Impact of HIV/Aids
[Cameroon Tribune]Kumba (Meme Division) The Cameroon Association for the Protection and Education of the Child, CAPEC, has been carrying out voluntary HIV screening with her "Mobile Clinic" team in Kumba and Konye sub division. CAPEC has as objective to mobilize and empower 5000 families (about 25000 people) in Meme Division to lead the elimination of HIV/AIDS in their lives, that of their families and in their communities. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
HRSA: Statement of Organization, Functions and Delegations of Authority
This notice outlines changes in authority of the Department of Health and Human Services (HHS), Health Resources and Services Administration (HRSA), including a naming change from the Division of Contract Services for HIV/AIDS, Health Professions, Rural Health and Grants Management to the Division of Population-Based Support. (Source: Federal Register updates via the Rural Assistance Center)
Hearing-aid intervention helps individuals gradually adjust to devices
(University of Missouri-Columbia) When individuals wear their hearing aids for the first time, they are flooded with sounds they have not heard in months or years. Ambient noises can be painful, irritating and difficult to ignore, causing some individuals to stop using their hearing aids right away. A University of Missouri researcher has developed an intervention that helps older adults gradually increase their hearing-aid use and satisfaction with the devices. (Source: EurekAlert! - Biology)
Fluorescent Cancer-Selective Alkylphosphocholine Analogs for Intraoperative Glioma Detection
CONCLUSION: CLR1501 (green) and CLR1502 (near infrared) are novel tumor-selective fluorescent agents for discriminating tumor from normal brain. CLR1501 exhibits a tumor-to-brain fluorescence ratio similar to that of 5-ALA, whereas CLR1502 has a superior tumor-to-brain fluorescence ratio. This study demonstrates the potential use of CLR1501 and CLR1502 in fluorescence-guided tumor surgery. ABBREVIATIONS: APC, alkylphosphocholine 5-ALA, 5-aminolevulinic acid GBM, glioblastoma multiforme GSC, glioblastoma stem cell GTR, gross total resection HGG, high-grade glioma PBS, phosphate-buffered solution PpIX, protoporphyrin IX T:N, tumor to normal brain (Source: Neurosurgery)
"The sky is the limit": adhering to antiretroviral therapy and HIV self-management from the perspectives of adolescents living with HIV and their adult caregivers.
CONCLUSIONS: These data highlight the importance of families and home environments in supporting adherence to ART among ALHIV. Skill-building and family-based interventions to prepare ALHIV and their adult caregivers for HIV self-management and HIV status disclosure by youth are of paramount importance. Future research and programmes also need to address the fears adolescents and families have regarding HIV-related stigma that shape young peoples' adherence behaviours. PMID: 25591915 [PubMed - in process] (Source: Journal of the International AIDS Society)
Paediatric HIV grows up: recent advances in perinatally acquired HIV
This review is an update focusing on the current status of paediatric HIV in the UK and Ireland. Successes in prevention of mother to child transmission are highlighted. The changing epidemiology of the UK cohort is summarised and the shift in emphasis of treatment guidelines beyond limiting short-term morbidity and mortality to ensuring optimal health status in adult life is discussed. Current and future challenges relating to an aging cohort, successful transition to adult services and the prospect of a lifetime on antiretroviral therapy (ART), as well as the possibility of ART-free survival are also considered. While numbers of HIV-infected children in the UK are now decreasing, lessons we have learned in the last 30&nbsp;years from this relatively small cohort are increasingly applicab...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Adherence in paediatric renal failure and dialysis: an ethical analysis of nurses' attitudes and reported practice
Minors have difficulty adhering to the strict management regimen required whilst on renal dialysis for chronic renal failure. This leads to ethical tensions as healthcare professionals (HCPs) and parents try, in the minor's best interests, to ensure s/he adheres. All 11 dialysis nurses working in a large, regional paediatric dialysis unit were interviewed about their perceptions and management of non-adherence and the ethical issues this raised for them. Participants reported negative attitudes to non-adherence alongside sympathy and feelings of frustration. They discussed the competing responsibilities between nurses, parents and minors, and how responsibility ought to be transferred to the minor as s/he matures; the need for minors to take responsibility ahead of transferring to adult se...
Baseline HIV-1 resistance, virological outcomes, and emergent resistance in the SECOND-LINE trial: an exploratory analysis
We report the relation of baseline virological resistance with virological failure and emergent resistance on study. Methods As part of the randomised open-label SECOND-LINE trial, second-line ART NtRTI selection was made by either genotype (local laboratory) or algorithm. Genotypic resistance for the entire cohort at baseline was assessed on stored samples at a central laboratory. Virological failure was defined as plasma viral load greater than 200 copies per mL. Baseline viral isolates were assigned genotypic sensitivity scores (GSSs) by use of the Stanford HIV Database version 6.3.1: a global GSS (gGSS), defined as the combined GSS for lamivudine or emtricitabine, abacavir, zidovudine, stavudine, didanosine, and tenofovir and a specific GSS (sGSS) defined as the GSS for the ART regime...
A Crusted Rash in a Patient With AIDS
(Source: JAMA)
Serum free light chains in patients with HIV infection: their association with markers of disease severity and antiretroviral use
Conclusions This study demonstrated that free light chain concentrations were significantly correlated with markers of HIV disease severity, suggesting ongoing B cell dysfunction despite ART use. Free light chain ratio was not significantly affected. (Source: Journal of Clinical Pathology)
EU Country Specific Recommendations for health systems in the European Semester process: Trends, Discourse and Predictors
The role of the European Union in relation to health systems and policies has been described in terms of three ?faces? [1]. First Article 168 of the Treaty [2] gives a basis for the EU to promote public health policies which is the longest established strand of health policy activity [3] and can be traced back to the initial vertical programmes on AIDs [4] and cancer [5] as well as activity in the realm of health information [6]. The second face refers to the role of the internal market in European health care policy. (Source: Health Policy)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
?I Created Something New with Something that Had Died?: Photo-Narratives of Positive Transformation Among Women with HIV
Abstract A dearth of research describes the strengths of women living with HIV (WLH), yet understanding these strengths can promote women?s well-being and healthy behavior. This analysis explores positive life transformations among WLH through photo-stories. WLH (N = 30) from three U.S. cities participated in a pilot photovoice project to tell their story of HIV. The project included three group meetings, an individual interview, and a public exhibit. Using qualitative strategies of theme and narrative analysis we identified positive transformations in women?s photo-stories. Participants were African American (83 %) and low income (83 %). Women described four major positive transitions in their lives including transformations related to healthfulness, spirituality, self-ac...
Antiretrovirals for Primary HIV Prevention: the Current Status of Pre- and Post-exposure Prophylaxis
Abstract In light of the 2 million HIV infections that occur globally each year, there is a need to optimize strategies that integrate biomedical and behavioral approaches to HIV prevention. Post-exposure prophylaxis (PEP) immediately after acute high-risk exposures and pre-exposure prophylaxis (PrEP) for those who engage in recurrent high-risk behaviors are promising bio-behavioral approaches to decreasing HIV transmission. Guidelines have recommended PEP for occupational and non-occupational exposures for over 15 years, but uptake of PEP has been limited, partly as a result of insufficient awareness of this intervention among persons at highest risk for acquiring HIV. However, since the publication of large randomized clinical trials demonstrating the efficacy of PrEP, and the ...
Factors Associated With Lack of Viral Suppression at Delivery Among Highly Active Antiretroviral Therapy-Naive Women With HIV: A Cohort Study.
CONCLUSION: A total of 13.1% of women who initiated HAART during pregnancy had detectable VL at delivery. The timing of HAART initiation and prenatal care, along with medication adherence during pregnancy, were associated with detectable VL at delivery. Social factors, including ethnicity and education, may help identify women who could benefit from focused efforts to promote early HAART initiation and adherence. PRIMARY FUNDING SOURCE: U.S. Department of Health and Human Services. PMID: 25599347 [PubMed - in process] (Source: Annals of Internal Medicine)
Local perturbation analysis: a computational tool for biophysical reaction-diffusion models.
Authors: Holmes WR, Mata MA, Edelstein-Keshet L Abstract Diffusion and interaction of molecular regulators in cells is often modeled using reaction-diffusion partial differential equations. Analysis of such models and exploration of their parameter space is challenging, particularly for systems of high dimensionality. Here, we present a relatively simple and straightforward analysis, the local perturbation analysis, that reveals how parameter variations affect model behavior. This computational tool, which greatly aids exploration of the behavior of a model, exploits a structural feature common to many cellular regulatory systems: regulators are typically either bound to a membrane or freely diffusing in the interior of the cell. Using well-documented, readily available bifurcatio...
HIV-1 Proteins Tat and gp120 Target the Developing Dopaminergic System.
Authors: Fitting S, Booze RM, Mactutus CF Abstract The current global estimate of children (&lt; 15 years of age) living with HIV and AIDS is 3.2 million, with the 240,000 newly infected children in the past year, i.e., another child infected approximately every two minutes [1]. The primary mode of HIV infection is through mother-to-child transmission (MTCT), occurring either in utero, intrapartum, or during breastfeeding. The effects of HIV-1 on the brain are thought to be mediated, in part, through the viral proteins Tat and gp120. This review focuses on the targets of HIV-1 proteins in the developing DAergic system, which appears to be specifically susceptible in HIV-1 infected children. Collectively, the data suggest that the DA system is a clinically relevant target in chronic...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
South, including N.C., has a lower HIV/AIDS survival rate than U.S.
Southern states ? including North Carolina ? have the lowest five-year survival rate among those diagnosed with HIV or AIDS in 2003-2004, according to new research conducted by Duke University and UNC-Chapel Hill. North Carolina has the third highest survival rate of the targeted states in the South, but still lower than the Unites States as a whole. In North Carolina, 15 percent of those diagnose with HIV and 26 percent of those diagnosed with AIDS do not survive. Both figures are higher than? (Source: bizjournals.com Health Care:Biotechnology headlines)
Immune Reconstitution Syndrome in HIV InfectionImmune Reconstitution Syndrome in HIV Infection
This HIV+ patient undergoing HAART presented to the emergency room with weakness, headache, neck stiffness and fever. What was the diagnosis? Applied Radiology (Source: Medscape Today Headlines)
Preconception Antiretroviral Therapy and Birth DefectsPreconception Antiretroviral Therapy and Birth Defects
Is HIV antiretroviral therapy taken before conception harmful to the fetus? AIDS (Source: Medscape Today Headlines)
[Correspondence] Ebola: lessons learned from HIV and tuberculosis epidemics
Amidst concerns of Ebola virus disease becoming a pandemic, the global medical community has mounted a crucial response. As the director of the US Centers for Disease Control and Prevention has said, ?we have to work now so this is not the world's next AIDS.?1 Although different from HIV/AIDS, we could apply lessons learned from the HIV and tuberculosis epidemics to address the Ebola crisis. This experience suggests four near-term objectives. (Source: The Lancet Infectious Diseases)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Kenya: HIV, TB in Adolescents Needs a Different Approach
[The Star]Do you remember that time when you had just passed thirteen years of age but were still below eighteen? You weren't technically an adult but neither were you a child. Your parents and relatives probably told you how 'now' you have become an adult and if you were a boy, that came with a certain sense of pride "You are now a man" but if you were a girl, the message was laced with caution, "You are now a woman, you have to be more careful." (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: Abalaka Offers Condition for HIV Vaccine After Court Stops Ban
[Daily Trust]Dr Jeremiah Abalaka, the man behind a controversial vaccine for HIV between 1999 and 2000, will only divulge recipe for his vaccine under a negotiated agreement, after a court ruled that federal government was wrong to ban it. (Source: AllAfrica News: HIV-Aids and STDs)
Malawi: Malawi Aids Commission Board Did Not Sanction Beam and Mulhakho Funding
[Malawi24]The National Aids Commission (NAC) board did not sanction the disbursement of funds to First Lady Gertrude Mutharika's Beautify Malawi Trust (Beam) and Mulhakho wa Alhomwe, Malawi24 has learnt. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: In a Converging World, Keep Talking
[Global Fund]The events in Paris last week captured the attention of the world, sparking sharp debate about freedom of expression, violence, the role of world religions, and what sometimes looks like a clash of cultures. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: Court Legalises Abalaka's HIV Vaccine, 16 Years After
[This Day]Abuja -In a landmark judgement, 16 years after the federal government officially banned the use of HIV vaccines discovered by Dr Jeremiah Abalaka, a Federal High Court sitting in Makurdi, Benue State, has declared the ban illegal and inconsequential. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Southern Africa: SADC Welcomes Zim Single-Dose HIV Strategy
[Namibian]THE secretary general of the SADC Parliamentary Forum Dr Esau Chiviya has hailed the decision by Zimbabwe to adopt the single-tablet HIV dose, saying the country had shown leadership in the fight against the epidemic. (Source: AllAfrica News: HIV-Aids and STDs)
South Africa: Strategy - Draft National Strategic Plan for HIV Prevention, Care and Treatment for Sex Workers
[Health-e]Released by the South African National AIDS Council (SANAC) on 12 January, this 49-page preliminary document outlines plans to, for instance, increase HIV and tuberculosis (TB) prevention, care and treatment among sex workers and families. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: I Will Release My HIV 'Vaccine' to Nigerian Government If ... - Abalaka
[Premium Times]Jeremiah Abalaka, a surgeon turned immunologist, who claimed to have developed a vaccine for the Human Immunodeficiency Virus, HIV, said he would only release his vaccine recipe to the Nigerian government under negotiated agreement. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: 16 Years After, Court Declares FG's Ban on Abalaka's HIV Vaccine Illegal
[This Day]In a landmark judgement, 16 years after the federal government officially banned the use of the HIV vaccines discovered by Dr. Jeremiah Abalaka, a Federal High Court sitting in Makurdi, Benue State, has declared the ban illegal and inconsequential. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: Achieving Zero New HIV Infection Via Pmtct Strategy
[Independent (Lagos)]Nigeria, with an estimated population of 160 million, ranks second to South Africa in the factsheet on countries with people living with HIV and AIDS worldwide, representing nine percent of the global burden of the disease. (Source: AllAfrica News: Health and Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Incidence of primary hypertension in a population-based cohort of HIV-infected compared to non-HIV-infected persons and the effect of combined antiretroviral therapy
Literature remains scarce on the impact of antiretroviral medications on hypertension in the HIV population. We used South Carolina Medicaid database linked with the enhanced HIV/AIDS system surveillance database for 1994-2011 to evaluate incident hypertension and the impact of combination antiretroviral therapy (cART) in HIV/AIDS population compared a propensity matched non-HIV control group. Multivariable, time-dependent survival analysis suggested no significant difference in incidence of hypertension between HIV and non-HIV control group. (Source: Journal of the American Society of Hypertension)
Of the China Root: A Case Study of the Early Modern Circulation of Materia Medica
The early modern rise of syphilis provoked similar anxieties to those that more recently accompanied the global spread of HIV/AIDS. It also stimulated global demand for remedies. I discuss one of the most popular, known as &lsquo;China root&rsquo; and usually identified with various species of Smilax. The drug and instructions for its use were spread westward from China by traders of all nationalities from 1535 onwards. Demand became global before being largely replaced in Europe by supplies of various American Smilax species, known collectively as &lsquo;Sarsaparilla&rsquo;. I examine the economic, political and cultural dynamics of this process and draw from them some conclusions about the early modern drugs trade and its effects on medical thought. (Source: Social History of Medicine)
Perry N. Halkitis, The AIDS Generation: Stories of Survival and Resilience
(Source: Social History of Medicine)
Cognitive function in women with HIV: Findings from the Women's Interagency HIV Study
Conclusions: The effect of HIV on cognition in women is very small except among women with low reading level or HIV-related comorbidities. Direct comparisons of rates of impairment in well-matched groups of HIV-infected men and women are needed to evaluate possible sex differences in cognition. (Source: Neurology)
Autologous Hematopoietic Stem Cells transplantation and genetic modification of CCR5 m303/m303 mutant patient for HIV/AIDS
HIV and AIDS is one of the biggest challenges all over the world. There are an approximately 34 million people living with the virus, and a large number of them become infected each year. Although there are some antiviral drugs for HIV viral load reduction, they are not sufficient. There is no cure for AIDS. Nowadays natural resistance or immunity has absorbed attentions. Because in some HIV positive patients progression trend is slow or even they indicate resistance to AIDS. One of the most interesting approaches in this category is CCR5 gene. (Source: Medical Hypotheses)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Zimbabwe: Aids Treatment Paralysed Us, Patients
[New Zimbabwe]HUNDREDS of people who were taking the first line of AIDS treatment have suffered irreversible side effects which have left some paralysed, an AIDS activist organisation has said. (Source: AllAfrica News: HIV-Aids and STDs)
Zimbabwe: Zimbabwe's Children Are the Battlefield in War to Contain HIV/Aids
[IPS]Harare -Fifty-one-year-old Mateline Msipa is living with HIV. Her 17-year-old daughter, born after Msipa was diagnosed with the virus, may also have it, but she has never been tested. (Source: AllAfrica News: Health and Medicine)
Zimbabwe: Children Are the Battlefield in War to Contain HIV/Aids
[IPS]Harare -Fifty-one-year-old Mateline Msipa is living with HIV. Her 17-year-old daughter, born after Msipa was diagnosed with the virus, may also have it, but she has never been tested. (Source: AllAfrica News: HIV-Aids and STDs)
Complementary and Alternative Medicine (CAM) practitioners? readiness for tobacco intervention training: Development and psychometric properties of a new measure
Conclusions CAM RTTI assessed three factors that can be critical to implementing effective tobacco intervention trainings for a CAM practitioner: (1) current tobacco intervention activity, (2) motivation/confidence and (3) comfort with non-CAM interventions. Moreover, it assessed these factors using language appropriate to CAM practitioners, providing the first measure, to our knowledge, specific to the development of tobacco intervention training for this group. (Source: Advances in Integrative Medicine)
The Association of the Rapid Assessment of Supervision Scale Score and Unintentional Childhood Injury.
This study was a secondary analysis of data from a case-crossover study, which examined the association of parental supervision and unintentional injury in children. Data on supervision characteristics for 3 time periods for each child were available, that is, one injury scenario and two "control" time periods when no injury occurred. Blinded to injury status, four raters independently evaluated adequacy of supervision in 132 supervision scenarios using the RASS. The individual RASS scores of the four raters and the group (mean) RASS score of the four raters were evaluated for associations with injury status. Individual scores from three of the four raters demonstrated significant associations of increasing RASS scores with injury. Increasing group RASS scores (odds ratio = 2.8; 95% confid...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Giant molluscum contagiosum: An unusual presenting complaint of paediatric HIV disease.
We report a widely disseminated, disfiguring facial molluscum contagiosum (MC) as a presenting complaint in an 11-year-old girl secondary to human immune-deficiency virus infection. A biopsy specimen demonstrated lobulated epidermal growth consisting of keratinocytes with large intracytoplasmic eosinophilic inclusion bodies. The patient was treated with highly active anti-retroviral therapy (HAART). The extent of MC in our patient was remarkable and subsequently improved dramatically after starting HAART. Normally MC does not similarly respond in patients with AIDS. PMID: 25601890 [PubMed - as supplied by publisher] (Source: Tropical Doctor)
Incidence of Herpes Zoster in HIV-Infected Adults in the Combined Antiretroviral Therapy Era: Results From the FHDH-ANRS CO4 Cohort.
CONCLUSIONS: ?The risk of HZ has declined markedly among HIV-infected patients in the cART era, but remains 3 times higher than in the general population. The risk increases moderately during the first 6 months of cART. PMID: 25601456 [PubMed - as supplied by publisher] (Source: Herpes)
Jason Patrick Set To Host The 'Big Love Weekend' To Benefit God's Love We Deliver
In 2013, Jason Patrick, who is affectionately known by many as Bearded Yogi, held a birthday party that doubled as a fundraiser for God's Love We Deliver, an organization that cooks and delivers meals to over 5,000 people each year in the New York City metropolitan area who are too sick to shop or cook for themselves. A year later, Patrick's birthday party morphed into a full-on celebrity-studded event called Big Love Weekend dedicated to help raise awareness and funds for God's Love We Deliver. For 2015, the yoga teacher, who was diagnosed with HIV in 2011 and, according to a press release, "became involved with God?s Love We Deliver after becoming a witness to those that were homebound and too sick to feed themselves," is aiming even higher. (Photo above: Jason Patrick with Parker P...
Long-term Safety and Efficacy of Atazanavir-based Therapy in HIV-infected Infants, Children and Adolescents: The Pediatric AIDS Clinical Trials Group Protocol 1020A
Conclusions: Use of once-daily ATV, with/without RTV, was safe and well tolerated in children, with acceptable levels of viral suppression and CD4 count increase. The primary AE, as expected, was an increase in bilirubin levels. (Source: The Pediatric Infectious Disease Journal)
Elder Women as Agents of Change
When you picture a traditional African grandmother, you probably see a woman who is caring but feeble, ever-present to provide her guidance and unconditional love. But it is not often that elder women are viewed as vital agents of social change. In 2010, while on a study abroad in South Africa, I met a group of grannies who transformed how I viewed advocacy and social change. Founded in 2001 by a group of ten South African elder women in Khayelitsha township, Grandmothers Against Poverty and AIDS (GAPA) is a grassroots organization aimed at decreasing poverty and AIDS in the surrounding communities, where some estimates suggest that over 27 percent of adults are HIV positive.[1] The organization now boasts over 300 grandmother members. These elder activist women have shaped me both p...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Qualitative study on the socio-cultural determinants of care of children orphaned by AIDS in the Ashanti and Eastern regions of Ghana
Conclusion: It is recommended that though some cultural and traditional practices are deeply rooted in communities and cannot be done away completely, orphan care policies on interventions should take into account these factors to mitigate their effects on the care of orphans. (Source: BioMed Central)
Battle Heats Up Over Legalisation of Sex Work in India
The view from a red-light district in India, where some three million sex workers are caught in the middle of a debate on legalisation. Credit: bengarrison/CC-BY-SA-2.0By Neeta LalNEW DELHI, Jan 16 2015 (IPS)Thirty-six-year-old Chameli Devi, a sex worker operating out of New Delhi&#8217;s G.B. Road &#8211; Asia&#8217;s largest red-light district, housing an estimated 12,000 of India?s three million sex workers ? is an unhappy woman these days.A contentious debate over the sex trade in India, following a call for legalisation by the National Commission for Women (NCW) ? a state-run body that advises the government on women-related policy matters ? has Devi worried.?In wealthier countries, many women genuinely choose this trade due to better income prospects and opportunities. But ...
Illustration of a Measure to Combine Viral Suppression and Viral Rebound in Studies of HIV Therapy
Abstract: Viral load is an important tool for assessing antiretroviral treatment efficacy. However, the most common viral load end point, virologic failure, may be flawed. We illustrate an alternative end point that estimates the average time patients spent suppressed before rebound in the AIDS Clinical Trials Group A5095 trial. Patients averaged 644 days suppressed in the 3-drug arm and 686 days suppressed in the 4-drug arm, for a difference of 42 days in favor of the 4-drug regimen (95% confidence interval: ?11 to 96). These results agree with results using virologic failure as the end point but better emphasize the separate suppression and rebound processes. (Source: JAIDS Journal of Acquired Immune Deficiency Syndromes)
Monitoring Outcomes for Newly Diagnosed and Prevalent HIV Cases Using a Care Continuum Created With New York City Surveillance Data
Conclusions: A minority of persons newly diagnosed with HIV and a narrow majority of PWHA achieved viral suppression and all intermediate care-related steps. Outcomes measured independently of previous care-related steps were higher, particularly for newly diagnosed persons. To improve outcomes among persons with HIV and reduce transmissibility, clinical and public health efforts should focus on linkage to care among newly diagnosed persons and viral suppression among PWHA. (Source: JAIDS Journal of Acquired Immune Deficiency Syndromes)
Efficacy of Second-Line Antiretroviral Therapy Among People Living With HIV/AIDS in Asia: Results From the TREAT Asia HIV Observational Database
Conclusions: Increased access to viral load monitoring to facilitate early detection of first-line ART failure and subsequent treatment switch is important for maximizing the durability of second-line therapy in Asia. Although second-line ART is highly effective in the region, the reported rate of failure emphasizes the need for third-line ART in a small portion of patients. (Source: JAIDS Journal of Acquired Immune Deficiency Syndromes)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Rates and Correlates of Antiretroviral Therapy Use and Virologic Suppression Among Perinatally and Behaviorally HIV-Infected Youth Linked to Care in the United States
Conclusions: There are continued challenges with successfully treating youth even once diagnosed and linked to HIV care. Strategies targeting barriers to ART access, use, and virologic suppression are needed to optimize the impact of the ?Treatment as Prevention? paradigm among PIY and BIY. (Source: JAIDS Journal of Acquired Immune Deficiency Syndromes)
Pharmacological Interactions Between Rifampicin and Antiretroviral Drugs: Challenges and Research Priorities for Resource-Limited Settings
Abstract: Coadministration of antituberculosis and antiretroviral therapy is often inevitable in high-burden countries where tuberculosis (TB) is the most common opportunistic infection associated with HIV/AIDS. Concurrent use of rifampicin and many antiretroviral drugs is complicated by pharmacokinetic drug?drug interactions. Rifampicin is a very potent enzyme inducer, which can result in subtherapeutic antiretroviral drug concentrations. In addition, TB drugs and antiretroviral drugs have additive (pharmacodynamic) interactions as reflected in overlapping adverse effect profiles. This review provides an overview of the pharmacological interactions between rifampicin-based TB treatment and antiretroviral drugs in adults living in resource-limited settings. Major progress has been made t...
Mucocutaneous Manifestations of HIV and the Correlation with WHO Clinical Staging in a Tertiary Hospital in Nigeria.
Authors: Oninla OA Abstract Skin diseases are indicators of HIV/AIDS which correlates with WHO clinical stages. In resource limited environment where CD4 count is not readily available, they can be used in assessing HIV patients. The study aims to determine the mucocutaneous manifestations in HIV positive patients and their correlation with WHO clinical stages. A prospective cross-sectional study of mucocutaneous conditions was done among 215 newly diagnosed HIV patients from June 2008 to May 2012 at adult ART clinic, Wesley Guild Hospital Unit, OAU Teaching Hospitals Complex, Ilesha, Osun State, Nigeria. There were 156 dermatoses with oral/oesophageal/vaginal candidiasis (41.1%), PPE (24.4%), dermatophytic infections (8.9%), and herpes zoster (3.8%) as the most common dermatoses. ...
HBV and HCV Coinfection among HIV/AIDS Patients in the National Hospital of Tropical Diseases, Vietnam.
Conclusion. Coinfection with viral hepatitis is common in HIV patients; further study of the impact and evolution of coinfection is necessary to find effective treatment algorithms. PMID: 25580287 [PubMed] (Source: AIDS Research and Treatment)
Closing eyes 'aids memory recall'
Closing your eyes when trying to recall events increases the chances of accuracy, researchers at the University of Surrey suggest. (Source: BBC News | Health | UK Edition)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Medication supply for people evacuated during disasters
This article is based on a systematic literature review on medication loss, the objectives of which were to identify the extent and implications of medication loss, to identify the burden of prescription refill, and to make recommendations on effective preparedness. The review revealed that medication loss, prescription loss and refills, and the loss of medical aids are a significant burden on the medical relief teams. The medical aids are not limited to drugs, but include routine medications, medical/allergy records, devices for specific care and daily life, and emergency medications. One possible solution is to make a personal emergency pack and for people to carry this with them at all times. To ensure that patients are adequately prepared, stakeholders, especially health professionals,...
Crystallographic studies of pharmacological sites in pentameric ligand-gated ion channels
Conclusions This review illustrates the wealth of structural insight gained by comparing all available structures of members of the pLGIC family to rationalize the pharmacology of structurally diverse drugs acting at topographically distinct sites. It will be highlighted how sites that had been described earlier using biochemical techniques can be rationalized using structural data. Surprisingly, the use of icosahedral symmetry allows to link together several modulation sites, in a way that was totally unanticipated. General Significance Overall, understanding the interplay between the different modulation sites at the structural level should help the design of future drugs targeting pLGICs. This article is part of a Special Issue entitled structural biochemistry and biophysics of membran...
NIH Grantees Overcome Hurdle to Kill HIV-Infected Cells Brought Out of Hiding
"A major obstacle to curing people of HIV infection is the way the virus hides in a reservoir primarily of dormant immune cells called resting memory CD4+ T cells. One potential approach to curing HIV infection is to awaken these latent CD4+ T cells so they start making HIV proteins. This would alert the immune system that the cells are infected, and, in theory, generate an immune response that kills them. It has been unclear, however, whether typical immune mechanisms for killing virally infected cells would eliminate HIV-infected CD4+ T cells awakened from the HIV reservoir." &nbsp; To learn more about this study, view the NIAID news release.&nbsp; (Source: AIDSinfo At-a-Glance: Offering Information on HIV/AIDS Treatment, Prevention, and Research, A Service of the U.S. Department of Heal...
New CDC Fact Sheet and Slide Set on HIV Care Continuum Available
The Centers for Disease Control and Prevention (CDC) recently published a new "Understanding the HIV Care Continuum" fact sheet and "HIV Care Continuum for the United States and Puerto Rico" slide set. The HIV care continuum is the series of steps from the time a person is diagnosed with HIV through the successful treatment of their infection with HIV medications. The fact sheet and slide set provide information and statistics on the continuum, including how CDC monitors the continuum. (Source: AIDSinfo At-a-Glance: Offering Information on HIV/AIDS Treatment, Prevention, and Research, A Service of the U.S. Department of Health and Human Services (DHHS))
Incidence and Long-term Outcomes of the Human Immunodef?ciency Virus Neuroretinal Disorder in Patients with AIDS
The objectives of this study were to determine the prevalence, incidence, risk factors, and outcomes of HIV neuroretinal disorder. (Source: Ophthalmology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
A clinicopathological cohort study of liver pathology in 301 patients with HIV/AIDS
Conclusion: In a high HIV burden area, drug induced liver injury due to antiretroviral therapy and cotrimoxazole, was a frequent clinicopathological finding. Mycobacterium tuberculosis was the leading opportunistic infection with more than half of patients fulfilling criteria for tuberculosis immune reconstitution syndrome. Liver biopsy remains a useful diagnostic procedure in this setting. This article is protected by copyright. All rights reserved. (Source: Hepatology)
Highly cold?active pectinases under wine?like conditions from non?Saccharomyces yeasts for enzymatic production during winemaking
This study demonstrates that cold?active pectinases from some A. pullulans strains were able to remain active at glucose, ethanol and SO2 concentrations usually found in vinification, and suggests their potential use as processing aids for low?temperature winemaking. This article is protected by copyright. All rights reserved. (Source: Letters in Applied Microbiology)
Long-acting drug effectively prevents HIV-like infection in monkeys
Because cabotegravir would require only one injection every three months, researchers hope this new drug, which has begun clinical testing, could improve some patients? ability to take HIV prevention medication properly. More &#187; (Source: The Rockefeller University Newswire)
South Africa: Sex and HIV in a Time of Criminalisation
[Daily Maverick]A plan on HIV in the sex work industry is due for release, and as stakeholders met this week to discuss issues affecting workers, the issue of legalisation was brought back on the agenda. For one Johannesburg sex worker, it's a crucial discussion, "because it's work, because we support families." (Source: AllAfrica News: HIV-Aids and STDs)
Southern Africa: The Impact of Stigma On Healthcare Workers Living With HIV
[Key Correspondents]Owen Nyaka -As she settles in her chair, Nomsa quickly scans the unfamiliar faces in the group and asks who her interpreter will be. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Africa: The Final Push for HIV in New Global Development Agenda
[Key Correspondents]With the mega-issues of poverty, hunger, health, education and global warming challenging the global community, HIV activists often struggle to be heard. But 2015, is not the year to take a back seat. (Source: AllAfrica News: HIV-Aids and STDs)
Review of Otorrhea Microbiology: Is There a Pathogenic Role of Corynebacter?
ConclusionCorynebacterium spp. may be underestimated in their potential to cause clinically significant otologic infections. Our results indicate a potential need for expanding surveillance for Corynebacterium spp. (Source: Otology and Neurotology)
Prevalence of opportunistic infections in HIV-positive patients in Bahrain: a four-year review (2009-2013)
Conclusions: Studying the pattern of OIs in HIV-infected patients in Bahrain is of paramount importance due to the scarcity of data in the Arab world. This will help to improve physicians? awareness to improve care of HIV-infected patients. (Source: The Journal of Infection in Developing Countries)
Mental health issues may increase HIV risk among gay, bisexual men
(Reuters Health) - Gay and bisexual men are at increased risk of acquiring the virus that leads to AIDS if they have mental health problems, according to a new study. (Source: Reuters: Health)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Novel Interventions to Prevent HIV and HCV Among Persons Who Inject Drugs
Abstract Persons who inject drugs (PWID) are at high risk for infection with and poor outcomes from HIV and hepatitis C virus (HCV). Well-established interventions for HIV/HCV prevention among PWID include syringe access, opioid agonist maintenance treatment, and supervised injection facilities, yet these interventions remain unavailable or inadequately resourced in much of the world. We review recent literature on biomedical and behavioral interventions to reduce the burden of HIV/HCV among PWID, with an emphasis on randomized controlled trials and quasi-experimental studies. Since 2013, there have been significant advancements in utilizing antiviral therapy and behavioral interventions for prevention among PWID, including approaches that address the unique needs of couples and s...
HIV?associated disseminated histoplasmosis in western French Guiana, 2002?2012
We describe the clinical and paraclinical presentation of DH, diagnostic tools, evolution and factors associated with 1?year mortality in HIV?infected patients from western French Guiana. Microbiologically proven AIDS?related DH in Saint Laurent du Maroni's hospital between May 2002 and May 2012 were retrospectively included. Among the 82 patients included, 58 (71%) were male, 44 (53%) presented concurrent histoplasmosis and HIV diagnosis and 63 (80%) had a CD4 cell count under 50 cells ?L?1. Almost all patients had weight loss (97%) and fever (95%), while 84% had digestive symptoms (63% diarrhoea), 55% lymphadenopathy, and 49% respiratory symptoms. Documented and presumed locations of H. capsulatum var capsulatum (Hcc) concerned almost all organs, with a particular affinity for ...
Informed consent for HIV cure research in South Africa: issues to consider
DiscussionNews that the "Berlin patient" and the "Mississippi baby" have both been "cured" of HIV brought hope to people living with HIV/AIDS in South Africa that a cure for HIV/AIDS is within reach. Despite the recent setbacks announced in the "Mississippi Baby" case, protocols aimed at curing HIV/AIDS are being developed in South Africa. However with evidence to suggest that participants in clinical trials do not understand the basic concepts in the informed consent process, there is concern that future participants in HIV/AIDS cure research will lack comprehension of the basic elements of future clinical trials that aims to cure HIV/AIDS and confuse research with clinical care.SummaryResearch ethics committees have an important role to play in ensuring that participants understand the b...
Understanding the Relationship Between Walking Aids and Falls in Older Adults: A Prospective Cohort Study.
CONCLUSIONS:: Using walking aids is a risk factor for future falls among the older population living in residential settings. A substantial proportion of the relationship between walking aids and future falls could be explained by an altered spatiotemporal gait pattern, increased age, and psychotropic drug intake. This finding supports the aim of extensive training periods and appropriate instructions on the proper use of walking aids in terms of adequate and safe gait patterns. PMID: 25594520 [PubMed - as supplied by publisher] (Source: Physical Therapy)
Know your foe: lessons from the analysis of tsetse fly behaviour.
Authors: Torr SJ, Vale GA Abstract The emergence of new vector-borne diseases requires new methods of vector control. These diseases are often zoonoses associated with wilderness areas, and established methods of vector control used in domestic settings (e.g., indoor-residual spraying, insecticide-treated bednets) are therefore inappropriate. Similar difficulties are also emerging with the control of 'old' vector-borne diseases such as malaria. Understanding the host-finding behaviour of vectors assists the development and application of control methods and aids the understanding of epidemiology. Some general lessons are illustrated by reference to a century of research on the host-finding behaviour of tsetse flies which transmit trypanosomes causing human and animal trypanosomiase...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Swaziland: Swaziland Aims for Malaria Elimination
[Global Fund]Mbabane -The Global Fund to Fight AIDS, Tuberculosis and Malaria and the Kingdom of Swaziland have strengthened their partnership by signing a new grant to support the elimination of malaria in the country by the end of 2015 with World Health Organisation certification by 2020. (Source: AllAfrica News: Malaria)
Namibia: Wilful Transmission of HIV Remains a Concern
[Namibian]IN the wake of the collective fight against the HIV-AIDS pandemic, wilful transmission of the virus continues to be a growing problem. (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: HIV+ Mothers Enlisted As Mentors in Campaign
[Capital FM]Nairobi -Emily* was diagnosed with the HIV virus in 2001. She was seven months pregnant with her second child at the time and discovered her status during mandatory testing on a routine visit to the clinic. (Source: AllAfrica News: HIV-Aids and STDs)
Reclaiming fertility awareness methods to inform timed intercourse for HIV serodiscordant couples attempting to conceive.
CONCLUSIONS: FAMs provide effective, economical and accessible options for HIV serodiscordant couples to conceive while minimizing unnecessary viral exposure. It is important for health care providers to initiate conversations about fertility desires in HIV-positive couples and to educate identified couples on safer conception strategies. PMID: 25579801 [PubMed - in process] (Source: Journal of the International AIDS Society)
Improved identification and enrolment into care of HIV-exposed and -infected infants and children following a community health worker intervention in Lilongwe, Malawi.
CONCLUSIONS: A multipronged approach utilizing CHWs to conduct HIV testing, link HIC into care and provide support to PMTCT mothers can dramatically improve the identification and enrolment into care of HIV-exposed and -infected children. PMID: 25571857 [PubMed - in process] (Source: Journal of the International AIDS Society)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Participation in debate: a qualitative assessment of the andalusian plan for HIV/AIDS
This paper aims to analyze the perspectives and meanings of social participation for the participants in a health program. A qualitative evaluation was conducted on the Andalusian Program against HIV/Aids and other sexually transmitted infections. The participants were selected through a theoretic sample: 20 HIV carriers, 19 representatives and volunteers from anti HIV associations and six administrative representatives. The information was obtained through semi-structured interviews and triangle groups; content analysis was performed. Participation has different meanings to the participant groups. HIV carriers consider it should be accomplished by communication mechanisms, support and prevention; association members consider it a right and a tool to change health policies, while two conce...
Diverse HIV epidemics among People Who Inject Drugs in Thailand: Evidence from respondent-driven sampling surveys in Bangkok and Chiang Mai
Since the late 1980s, people who inject drugs (PWID) have been tracked as a key population in annual national HIV sentinel surveillance prevalence surveys conducted by the Thailand Ministry of Public Health (MOPH). These surveys have shown that HIV seroprevalence remained high at 30-50% over the last two decades (Brown et al., 1994; Thai National AIDS Committee, 2014). However, participants in these surveys have been recruited exclusively from drug treatment centers where the main service is methadone treatment for opiate users. (Source: Drug and Alcohol Dependence)
Performance of the QuantiFERON-TB Gold Interferon Gamma Release Assay among HIV-Infected Children in Botswana
Interferon gamma release assays (IGRAs) are poorly studied in HIV-infected children. The authors prospectively evaluated QuantiFERON-TB Gold results and family-described tuberculosis (TB) risk factors in 100 HIV-infected children in Botswana. Median age was 10.2 years; 58 were girls, 92 had received the Bacillus Calmette&ndash;Gu&eacute;rin (BCG) vaccine, 98 were receiving antiretroviral therapy, and the median body mass index was 15.8 kg/m2. Eighty-nine children had undetectable viral loads and the median CD4 count was 962 cells/mm3. Eighteen children had been treated for TB in the last 3 years. In the last 3 years, 36 (including 9 with TB) had contact with persons with TB (26 within/15 outside the home and 5 had &gt;1 contact). In all, 96 children had negative IGRAs, 3 were indeterminate...
Parks as a Tool for HIV Management
Access to parks improves overall health outcomes in the general population. Given that HIV infection has become a chronic disease to manage, among populations engaged in medical care, parks may be promoted as physical activity opportunities in order to manage chronic comorbid conditions. We conducted a cross-sectional examination of the relationships between sociodemographic and biomedical characteristics to park proximity among 635 individuals receiving outpatient HIV care. The data collected included HIV-related biomarkers, depression, and diagnoses of other chronic diseases. The total acres of parks an individual is exposed within one-quarter mile from their home were assessed. The cohort included 635 individuals (67% men, 73% black, and 21% white, mean age 42 years). Unemployment was n...
Rate of and Predicting Factors for Virologic Failure in HIV-Infected Patients with Persistent Low-Level Viremia under Antiretroviral Therapy
To determine the rate of and predicting factors for virologic failure among HIV-infected patients with persistent low-level viremia (PLV) under antiretroviral therapy (ART), a retrospective cohort study was conducted among HIV-infected patients who experienced PLV under ART. Persistent low-level viremia was defined as HIV RNA level at 50 to 1000 copies/mL for at least 2 consecutive visits. Of 68 patients, mean &plusmn; standard deviation age was 35.2 &plusmn; 9.0 years and 64.7% were males. Median (interquartile range [IQR]) CD4 count was 94 (26-264) cells/mm3 and baseline HIV RNA was 112 000 (1 090-461 500) copies/mL. During the median (IQR) follow-up period of 5.7 (3.4-10.3) years of ART, the rate of virologic failure was 38.2%. In multivariate analyses, only maximum amplitude of HIV RNA...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Plasmoblastic Lymphoma as Cause of Perianal Fistula: A Case Report and Literature Review
We report the case of a 33-year-old HIV-infected man who presented with a recurrent, nonhealing perianal fistula. After multiple benign biopsies, the diagnosis of plasmablastic lymphoma (PBL) eventually was made. The patient underwent chemotherapy and radiation with a complete response. Perianal fistulas are frequent in HIV-positive patients, but PBL as a cause is extremely rare. This often delays the diagnosis and treatment of this highly aggressive disease. We review the literature and discuss the pitfalls in the diagnosis and management of the disease. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
Bacillary Angiomatosis Masquerading as Kaposi's Sarcoma in East Africa
Conclusions: These 3 cases, to our knowledge, are the first reports of BA in East Africa in the biomedical literature. Each had been originally incorrectly diagnosed as KS. We speculate BA is underdiagnosed and underreported in resource-poor regions, such as sub-Saharan Africa, that have high endemic rates of HIV infection. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
Racial Differences in the Accuracy of Perceived Partner HIV Status among Men who have Sex with Men (MSM) in Atlanta, Georgia
We compared perceptions of partner HIV status to HIV test results in a cross-sectional study of sexual networks of men who have sex with men (MSM) in Atlanta. We then examined differences between black and white MSM in the predictive value of perceived partner status. We recruited men ("seeds") using time-space venue sampling. These seeds then referred up to three partners, who could also refer partners. All participants reported sexual behavior and HIV status for recent partners and received HIV tests. For partners who enrolled, we compared laboratory diagnoses to their partner&rsquo;s perception of their status. Black MSM who perceived themselves to be HIV negative were more likely than perceived-negative white MSM to have a positive partner among those they perceived to be HIV negative ...
Medical Risks and Benefits of Newborn Male Circumcision in the United States: Physician Perspectives
Conclusions: In 2008, only about one-third of the physicians surveyed thought that the benefits of male circumcision outweighed the risks and recommended it to parents of newborn sons. These attitudes may be relevant to the declining circumcision rates in the United States. Repeat surveys may be useful, given the new AAP and ACOG recommendations. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
Characteristics and Follow-up of Newly Managed HIV-Infected Patients in the National Referral Center in Ouagadougou, Burkina Faso
Conclusion: Laboratory tests and highly active antiretroviral therapy make the management of patients easier, but a majority of them still presented late and were still lost to follow-up. Nevertheless, we have excellent treatment success. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Identifying Subgroups of Care Providers Participating in a Telehealth Educational Intervention: Hierarchical Cluster Analysis of Evaluation Data
Conclusion: Methodological contributions of the study are discussed. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
The Acute Care Physical Therapy HIV/AIDS Patient Population: A Descriptive Study
This study was based on an analysis of an existing database compiled from 475 medical records of people living with HIV/AIDS admitted to an acute-care hospital in New York City in 2004. The characteristics of patients with HIV infection that received physical therapy were determined. Differences between patients with HIV infection that did and did not receive physical therapy, as well as predictors of receipt of physical therapy, were identified. The physical therapy subgroup (n = 69) had a mean age of 48.3 years, consisted of more men than women, and was predominately black, with public health insurance. Admissions were commonly due to non-AIDS-defining illness as the primary diagnoses, accompanied by several comorbidities. Admissions often presented with functional deficits, incurred a p...
Adherence among Rural HIV-Infected Patients in the Deep South: A Comparison between Single-Tablet and Multi-Tablet Once-Daily Regimens
Conclusion: Treatment-experienced patients enrolled in ADAP are less likely to be adherent. A QD PI-based MTR may result in comparable adherence to an STR in a rural HIV-infected population. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
Lack of Knowledge about Mother-to-Child HIV Transmission Prevention in Pregnant Women at Tijuana General Hospital, Baja California, Mexico
The objective of this study was to identify determinants of human immunodeficiency virus (HIV) knowledge regarding mother-to-child transmission (MTCT) among pregnant women at Tijuana General Hospital, Baja California, Mexico. Between March and November 2003, patients from the prenatal care (n = 1294) and labor and delivery (L&D) units (n = 495) participated in a cross-sectional study to measure HIV knowledge. Less than one-third (30%) knew that HIV could be transmitted to a child during delivery, and 36% knew that HIV could be transmitted by breast-feeding. Only 27% knew that an MTCT could be prevented. Prenatal patients were more likely to know that MTCT was preventable (prenatal: 31% versus L&D 25%; P = .02). Logistic regression indicated that prenatal patients (odds ratio = 1.49...
Time for Option B+? Prevalence and Characteristics of HIV Infection among Attendees of 2 Antenatal Clinics in Buea, Cameroon
As countries consider a wider use of triple antiretroviral therapy (ART) in pregnancy, which in recent World Health Organization guidelines is called Option B+, this study sought to explore the potential implications of adopting Option B+ by characterizing HIV infection in pregnant women attending 2 semiurban antenatal clinics in Cameroon. In a descriptive cross-sectional study, consenting women were screened for HIV; positive samples were confirmed using an enzyme-linked immunosorbent assay test, and CD4 levels and HIV viral loads were determined using flow cytometry and reverse transcription&ndash;polymerase chain reaction, respectively. The seroprevalence of HIV in the 407 pregnant women screened was 8.4% (95% confidence interval: 5.9%-11.5%). The majority (82.4%) of HIV-positive women ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
HIV Treatment as Prevention in Jamaica and Barbados: Magic Bullet or Sustainable Response?
This discursive article introduces HIV treatment as prevention (TasP) and identifies various models for its extrapolation to wider population levels. Drawing on HIV surveillance data for Jamaica and Barbados, the article identifies significant gaps in HIV response programming in relation to testing, antiretroviral treatment coverage, and treatment adherence, thereby highlighting the disparity between assumptions and prerequisites for TasP success. These gaps are attributable, in large part, to sociocultural impediments and structural barriers, severe resource constraints, declining political will, and the redefinition of HIV as a manageable, chronic health issue. Antiretroviral treatment and TasP can realize success only within a combination prevention frame that addresses structural facto...
Revitalizing Condom-Centered HIV Prevention Strategies
Abstract HIV infection rates remain steady in the USA despite the numerous prevention programs and tools available. Condoms play a central role in HIV prevention because they are highly effective, readily available, and affordable. Unfortunately, condom promotion efforts often incite fear as a motive force, while also taking the common ?one-size-fits-all? approach. Reframing condom promotion through a sexual health framework, focusing on pleasure and highlighting condom fit issues, improves intervention efficacy. Condom distribution policies may further perpetuate condom users? difficulty, by withholding particular condom styles, brands, and information highlighting the nuances in shape, size, and material. Condom education and distribution practices focused on pleasure, pro...
Bioinformatics and HIV Latency
Abstract Despite effective treatment, HIV is not completely eliminated from the infected organism because of the existence of viral reservoirs. A major reservoir consists of infected resting CD4+ T cells, mostly of memory type, that persist over time due to the stable proviral insertion and a long cellular lifespan. Resting cells do not produce viral particles and are protected from viral-induced cytotoxicity or immune killing. However, these latently infected cells can be reactivated by stochastic events or by external stimuli. The present review focuses on novel genome-wide technologies applied to the study of integration, transcriptome, and proteome characteristics and their recent contribution to the understanding of HIV latency. (Source: Current HIV/AIDS Reports)
The financial and service implications of splitting fixed-dose antiretroviral drugs - a case study
In 2010/2011, regional commissioners withdrew payment for the fixed-dose combination Combivir, forcing a switch to component drugs. This was deemed clinically acceptable and annual savings of &pound;44 k expected. We estimated the true costs of switching and examined patient outcomes. Information for 46 patients using Combivir was extracted from case notes for each clinical contact in the 12 months pre- and post-switch (clinician seen, tests, antiretrovirals). Post-switch care costs &pound;93/patient more annually versus pre-switch (95% CI &pound;424 to &pound;609), yielding &pound;4278/year more post-switch for all patients. Drug and pathology costs were more expensive post-switch and extra clinical visits required. None of these results were statistically significant. Forty-two per cent ...
Prevalence of antibodies against Treponema pallidum among HIV-positive patients in a tertiary care hospital in Mexico
Our objective was to determine the seroprevalence of syphilis among HIV-infected patients in a tertiary care hospital in Mexico City. A cross-sectional study was developed, and 318 HIV-positive patients were evaluated from January to February 2013 at Hospital de Infectolog&iacute;a, National Medical Center &lsquo;La Raza&rsquo; (a tertiary care hospital specialising in infectious diseases in Mexico City). Laboratory data were screened for the detection of antibodies against Treponema pallidum. Patients completed a questionnaire relating to socio-demographic data and factors associated with syphilis. Of the 318 patients, 83% were men. The mean age &plusmn; SD was 36 &plusmn; 11 years; 52% were men who have sex with men and 47% had undertaken higher education. The overall seroprevalence of s...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Medical care following multiple perpetrator sexual assault: A retrospective review
This paper describes the healthcare needs of victims of multiple perpetrator sexual assault (MPSA) and single perpetrator sexual assault (SPSA) presenting to the Haven sexual assault referral centre in south-east London, and aims to identify any characteristics that might be related to attendance at follow-up appointments. We reviewed standardised casenotes of 136 MPSA victims and 139 SPSA victims attending for forensic medical examination (FME) between 1 July 2005 and 31 July 2009. MPSA victims reported a higher rate of stranger assaults, higher rates of vaginal, anal and oral rapes, more rapes at multiple anatomical sites or multiple rapes and were more likely to sustain injuries, all of which put MPSA victims at higher risk of subsequent health problems. Rates of attendance at follow-up...
Determination of the influence of home delivery of HIV therapy on virological outcomes and adherence
This study suggests that expanding home delivery as a model of care in London HIV clinics is safe and does not affect adherence and patient outcomes as indicated by HIV viral load and CD4%. (Source: International Journal of STD and AIDS)
The effectiveness of an education intervention to prevent chlamydia infection among Greenlandic youth
The purpose of this study was to implement a sexual health behavioural intervention in Greenland in order to reduce sexually transmitted infection rates among a population of Greenland youth. This behavioural intervention was called Inuulluataarneq (Having the Good Life). Inuulluataarneq&rsquo;s objects included: (1) increase Greenlandic youth&rsquo;s overall knowledge about sexually transmitted infections and sexual health; (2) increase parent/guardian-youth communication about topics related to sexually transmitted infections and sex; and (3) increase consistent condom use among Greenlandic youth. We hypothesised that increased awareness of sexually transmitted infections and sexual health as well as increased communication between parents/guardians and their adolescent children would in...
Clinical research should be a priority in the NHS - but what do genito-urinary medicine clinic staff think?
Clinical research improves patient care and is a government priority. We sought the opinions of genito-urinary medicine clinic staff regarding undertaking research, any barriers they perceived, and methods to optimise study recruitment. Questionnaires were offered to everyone working in the genito-urinary medicine clinic over a one-week period. In addition, four focus groups were held with genito-urinary medicine clinic staff. Forty-three questionnaires were completed. All respondents stated that research was important; however, 14.0% worried that it affected patient care and 16.3% would rather see patients without having to consider research. Doctors were more likely to enjoy discussing studies than other healthcare staff (p = 0.029) and were less likely to think that too many studies wer...
Risk for HIV following a diagnosis of syphilis, gonorrhoea or chlamydia: 328,456 women in Florida, 2000-2011
Several effective interventions are available for preventing HIV in women. Targeting interventions requires understanding their risk of acquiring HIV. We used surveillance data to estimate risks of HIV acquisition for 13&ndash;59-year-old women following a diagnosis of syphilis, gonorrhoea or chlamydia in Florida during 2000&ndash;2009. We excluded women reported with HIV before their STI, and measured HIV reported subsequent to STI (through 2011). Rates were compared to women with no reported STI. A total of 328,456 women had: syphilis (3325), gonorrhoea (67,784) or chlamydia (257,347). During 2,221,944 person-years of follow-up, 2118 of them were diagnosed with HIV. For women with no STI reported, during 64,763,832 person-years, 19,531 were reported with HIV. The crude rate of subsequent...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Prevalence and risk factors associated with HIV infection, hepatitis and syphilis in a state prison of Sao Paulo
Given the importance of the control of sexually transmitted infections in the general population and specifically in the prison system, we rolled out this cross-sectional study in 2007. Standard questionnaires and blood samples were accessed among 680 prisoners. The protocol was approved by the Ethics Committee. We determined the following seroprevalences: HIV, 1.8% (95%CI = 0.1&ndash;3.3); HBV, 21.0% (95%CI = 17.8&ndash;25.1); HBV, 5.3% (95%CI = 3.5&ndash;7.6) and syphilis 5.3% (95%CI = 3.5&ndash;7.6). Logistic regression identified significant associations with (p &lt; 0.05): HIV: injectable drug use (OR = 15.4), age over 30 years (OR = 13.3), cocaine use (OR = 5.4) and crack-cocaine use (OR = 5.2); HBV: injectable drug use (OR = 3.4), history of previous sexually transmitted infection (...
Assessing the role of peripheral CD8 T cells in neurocognitive impairment in HIV-infected men who have sex with men: data from the MSM Neurocog Study
Studies have suggested CD8 lymphocytes may be a possible marker for inflammation, which is believed to be a contributing factor to neurocognitive impairment. Individuals enrolled in the MSM Neurocog Study were analysed. Those with depression, anxiety or mood disorders were excluded. Individuals with neurocognitive impairment were identified using the Brief NeuroCognitive Screen and compared to those with normal scores. CD4 and CD8 T cell values and CD4:CD8 ratios were compared between groups. In all, 144 men, aged 18&ndash;50 years, were included in the analysis. Twenty were diagnosed with neurocognitive impairment. We were unable to identify any significant difference between current, nadir or peak CD4 and CD8 counts. CD4:CD8 ratios and CD4:CD8 ratio inversion (&lt;1) were also found to b...
The relationship between body composition and knee structure in patients with human immunodeficiency virus
This study aimed to examine relationships between body composition and knee cartilage volume, as assessed by magnetic resonance imaging in HIV infection. 35 ART-treated HIV-infected men aged 51.7 years (mean) 7.9 (SD) and 18 healthy men aged 49.5 years (mean) 6.4 (SD) participated. Cartilage volume was measured on magnetic resonance imaging of the dominant knee using validated methods. Body composition was measured using dual x-ray absorptiometry. HIV-infected participants had less total body and gynoid fat (kg) (p = 0.04 and p = 0.007, respectively) and more percent android fat mass and percent trunk fat mass (p = 0.001 and p &lt; 0.001, respectively) than controls. In HIV-infected participants there was an inverse association between total body fat mass and average tibial cartilage volum...
Performance of a Mathematical Model to Forecast Lives Saved from HIV Treatment Expansion in Resource-Limited Settings
Conclusions. Validation and calibration resulted in a good-fitting model appropriate for health policy decision making. Using local data in a policy model-building process is feasible in resource-limited settings. (Source: Medical Decision Making)
Pharmacokinetic Enhancement in HIV Antiretroviral Therapy: A Comparison of Ritonavir and Cobicistat.
Authors: Renjifo B, van Wyk J, Salem AH, Bow D, Ng J, Norton M Abstract Inhibition of the cytochrome p450 3A4 enzyme system leads to increases in plasma concentrations of coadministered antiretroviral agents - a concept known as pharmacokinetic boosting. Ritonavir and cobicistat are potent inhibitors of cytochrome p450 3A4. Ritonavir was initially developed as an HIV protease inhibitor, but is currently used primarily as a pharmacokinetic boosting agent for other HIV and hepatitis C protease inhibitors. Cobicistat is a boosting agent for the integrase inhibitor elvitegravir and the protease inhibitors atazanavir and darunavir. Phase III data showed that atazanavir + cobicistat + tenofovir/emtricitabine had non-inferior efficacy and resulted in similar CD4 T-cell count increases to ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Acute pancreatitis associated with dolutegravir and lamivudine/abacavir administration
No abstract available (Source: AIDS)
Changes in kidney function in patients with suppressed HIV RNA who substitute their protease inhibitor with atazanavir/ritonavir
No abstract available (Source: AIDS)
Heroin use in Indonesia is associated with higher expression of CCR5 on CD4+ cells and lower ex-vivo production of CCR5 ligands
Opioid use may affect HIV infection through altered expression of HIV co-receptors. This was examined in Indonesia among antiretroviral therapy-naive HIV patients, many of whom use drugs. C-C chemokine receptor type 5 (CCR5) expression on CD4+ cells was higher in heroin (P?=?0.007), methadone (P?=?0.024) and former opioid users (P?=?0.003) compared to nonusers, whereas production of RANTES and other CCR5 ligands was similar or lower. This suggests that opioids can affect HIV susceptibility through up-regulation of CCR5 or down-regulation of its ligands. (Source: AIDS)
Seven years of chronic hepatitis C virus infection in an HIV-infected man without detectable antibodies
No abstract available (Source: AIDS)
Impact of low-level viremia on clinical and virological outcomes in treated HIV-1-infected patients
Conclusion: LLV200?499 was strongly associated with virological failure, but not with AIDS event/death. Our results support the US guidelines, which define virological failure as a confirmed viral load above 200?copies/ml. (Source: AIDS)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Drug resistance and plasma viral RNA level after ineffective use of oral pre-exposure prophylaxis in women
Conclusions: Drug resistance detected during ineffective PrEP use had characteristics suggesting transmitted infection or incubating infection prior to starting PrEP. (Source: AIDS)
Modelling the HIV epidemic among MSM in the United Kingdom: quantifying the contributions to HIV transmission to better inform prevention initiatives
Conclusion: The majority of the new HIV infections among MSM in the United Kingdom during 2001?2020 is expected to be accounted for by a small group of younger and highly sexually active individuals, living with undiagnosed HIV in the asymptomatic stage. Bringing this group into HIV/AIDS care by improving testing uptake is a vital step for preventing onward transmission and will determine the success of using ART as prevention. (Source: AIDS)
Tuberculosis incidence after 36 months? isoniazid prophylaxis in HIV-infected adults in Botswana: a posttrial observational analysis
Conclusion: The benefit of 36IPT for TB prevention declined posttrial in this cohort. Adjunctive measures are warranted to prevent TB among HIV-infected persons receiving long-term ART in TB-endemic settings. (Source: AIDS)
Incomplete adherence among treatment-experienced adults on antiretroviral therapy in Tanzania, Uganda and Zambia
Conclusion: Results support more in-depth investigations of the role of traditional healers, and the development of interventions to address alcohol abuse and internalized stigma among treatment-experienced adult ART patients. (Source: AIDS)
HAART slows progression to anal cancer in HIV-infected MSM
The objective is to investigate the impact of antiretrovirals in the time to the development of anal cancer in HIV-positive MSM. Design: A retrospective analysis of cases of anal cancer in a cohort of HIV-positive MSM receiving antiretrovirals between 1988 and 2008. Methods: Time from first CD4+ cell count or HIV RNA viral load test to anal cancer diagnosis was analysed using Cox regression and Kaplan?Meier curves. Anal cancer cases treated in the era prior to HAART ( (Source: AIDS)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Statin therapy decreases N-terminal pro-B-type natriuretic peptide in HIV: randomized placebo-controlled trial
Conclusion: Rosuvastatin reduces plasma NT-proBNP in HIV-infected participants on antiretroviral therapy. NT-proBNP correlated with several measures of CVD risk, independent of inflammation markers. (Source: AIDS)
Antiretroviral therapy reduces neurodegeneration in HIV infection
Conclusion: We conclude that virally suppressive ART protects against cortical neurodegeneration. Further, we find evidence supporting the causal chain from treatment-mediated peripheral and central nervous system viral load suppression to reduced neurodegeneration and improved neurocognitive outcomes. (Source: AIDS)
Early viral suppression improves neurocognitive outcomes in HIV-infected children
Conclusion: Virologic suppression during infancy or early childhood is associated with improved neurocognitive outcomes in school-aged PHIV+ children. In contrast, CPE scores showed no association with neurocognitive outcomes. (Source: AIDS)
HIV-1 viral infectivity factor interacts with microtubule-associated protein light chain 3 and inhibits autophagy
Conclusion: Our study unveils that Vif inhibits autophagy independently of its action on APOBEC3G and, therefore, suggest a new function of this viral protein in restricting innate antiviral mechanisms. (Source: AIDS)
Increased carotid intima?media thickness is not associated with T-cell activation nor with cytomegalovirus in HIV-infected never-smoker patients
Conclusion: In HIV-infected individuals at low cardiovascular disease risk, our data show that the increased risk of carotid atherosclerosis is not associated with immunological markers described to be associated with HIV disease progression. (Source: AIDS)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
TB-IRIS, T-cell activation, and remodeling of the T-cell compartment in highly immunosuppressed HIV-infected patients with TB
Conclusions: A distinct pattern of pre-ART T-cell and cytokine markers appear to poise the immune response of certain patients to develop TB-IRIS. Experience of TB-IRIS is then associated with long-term remodeling of the CD4+ T-cell memory compartment towards an effector memory-dominated phenotype. We speculate that these pre and post-ART TB-IRIS-associated immune parameters may contribute to superior immune control of TB/HIV co-infection and better clinical outcome. (Source: AIDS)
Could antiretroviral neurotoxicity play a role in the pathogenesis of cognitive impairment in treated HIV disease?
Whilst effective antiretroviral therapy is protective against the more severe forms of HIV-associated brain disease, there remains a large burden of clinically symptomatic cognitive impairment in the modern era. Although several potential pathogenic mechanisms have been proposed, the underlying pathology remains elusive. In this review, we summarize the evidence describing neuronal toxicity of antiretroviral agents themselves in both preclinical and clinical situations, as well as the potential pathological mechanisms underlying this toxicity. We also consider the implications for future practice and clinical research in which case determining optimal antiretroviral combinations that effectively suppress HIV replication whilst minimizing neurotoxic effects on the central nervous system may...
Transmission of HIV drug resistance: lessons from sensitive screening assays
Purpose of review: The review discusses new technologies for the sensitive detection of HIV drug resistance, with a focus on applications in antiretroviral treatment (ART)-naïve populations. Recent findings: Conventional sequencing is well established for detecting HIV drug resistance in routine care and guides optimal treatment selection in patients starting ART. Access to conventional sequencing is nearly universal in Western countries, but remains limited in Asia, Latin America, and Africa. Technological advances now allow detection of resistance with greatly improved sensitivity compared with conventional sequencing, variably increasing the yield of resistance testing in ART-naïve populations. There is strong cumulative evidence from retrospective studies that sensitive detection of ...
Advancing the HIV cure agenda: the next 5 years
Purpose of review: To explore how ethical considerations, improved diagnostics and data from clinical trials might see the lowering of some of the barriers blocking a cure for HIV infection over the next 5 years. Recent findings: Despite the recent well publicized but eventually disappointing case reports, there remains only one successful HIV cure, the ?Berlin patient?. We will review the data suggesting that more potent agents might achieve in-vivo viral activation and explore the tantalizing phenomenon of ?posttreatment control? following treatment in primary HIV infection. We will also explore how new assays and novel interventions might move the field forward. Summary: There is a need for new agents that can be safely tested to impact the viral reservoir, a more meaningful und...
Malawi: High Default Rate Compromising HIV Aids Fight in Nkhata Bay
[Malawi News Agency]Nkhata Bay -High default rate among people on Anti Retroviral Therapy (ART) has been singled out as a major challenge compromising HIV and AIDS fight in Nkhata Bay District. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
The Religious?Spiritual Self-Image and Behaviours Among Adolescent Street Children in Harare, Zimbabwe
Abstract The present study sought to explore the relationship between street childhood and adolescent religious?spiritual self-image. In Zimbabwe, there has been a rise in street children population in the urban centres. The current study investigated whether adolescent street children live and work in an eco-developmentally risky context for the development of positive religious?spiritual self-image. This rise in street children population has been in the context of a socio-politico-economic crisis, which was marked by record inflation rates and the HIV and AIDS pandemic. The research objectives were to investigate the nature of religious?spiritual self-image for street-living adolescent children, and to determine the effects of self-image on the behaviour of street-living...
Kenya: Muslims Told to Do HIV Tests Before Marriage
[The Star]RELIGIOUS leaders in Kilifi county now want the Chief Kadhi to make it compulsory for newly weds to know their HIV-Aids status before they get married. (Source: AllAfrica News: Health and Medicine)
Nigeria: Targeting HIV Treatment Goals Through Decentralisation, Increased Funding
[Vanguard]Information on number of children receiving peadiatric ARV is crucial in appraising Nigeria's performance with regards to Prevention of Mother to Child Transmission of HIV, PMTCT, strategy. (Source: AllAfrica News: HIV-Aids and STDs)
Progress toward an HIV cure highlighted in special issue of AIDS Research and Human Retroviruses
(Mary Ann Liebert, Inc./Genetic Engineering News) A cure for HIV/AIDS is the ultimate goal of rapidly advancing research involving diverse and innovative approaches. A comprehensive collection of articles describing the broad scope and current status of this global effort is published in a special issue of AIDS Research and Human Retroviruses. (Source: EurekAlert! - Medicine and Health)
Teriparatide treatment of osteoporosis in an HIV-infected man: a case report and literature review
No abstract available (Source: AIDS)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Hepatitis B reverse seroconversion in a patient with well controlled HIV infection: a case report and a review of the literature
No abstract available (Source: AIDS)
Estimating the Number of Sex Workers in South Africa: Rapid Population Size Estimation
Abstract Although recognized as a vulnerable population, there is no national population size estimate for sex workers in South Africa. A rapid sex worker enumeration exercise was undertaken in twelve locations across the country based on principles of participatory mapping and Wisdom of the Crowd. Sites with a range of characteristics were selected, focusing on level of urbanisation, trucking, mining and borders. At each site, sex worker focus groups mapped local hotspots. Interviews with sex workers at identified hotspots were used to estimate the numbers and genders of sex workers working in each. Estimates provided in the literature were combined with enumeration exercise results to define assumptions that could be applied to a national extrapolation. A working estimate was re...
Stem Cell Gene Therapy for HIV: Strategies to Inhibit Viral Entry and Replication
Abstract Since the demonstration of a cure of an HIV+ patient with an allogeneic stem cell transplant using naturally HIV-resistant cells, significant interest in creating similar autologous products has fueled the development of a variety of ?cell engineering? approaches to stem cell therapy for HIV. Among the more well-studied strategies is the inhibition of viral entry through disruption of expression of viral co-receptors or through competitive inhibitors of viral fusion with the cell membrane. Preclinical evaluation of these approaches often starts in vitro but ultimately is tested in animal models prior to clinical implementation. In this review, we trace the development of several key approaches (meganucleases, short hairpin RNA (shRNA), and fusion inhibitors) to modifi...
T Memory Stem Cells and HIV: a Long-Term Relationship
This article summarizes recent studies investigating the role of TSCM in HIV/SIV infection. (Source: Current HIV/AIDS Reports)
The Impact of Married Individuals Learning HIV Status in Malawi: Divorce, Number of Sexual Partners, and Condom Use With Spouses
This study improves upon previous studies on this topic because the randomized incentives affecting the propensity to be tested for HIV permit control for selective testing. Instrumental variable probit and linear models are estimated, using a randomized experiment administered as part of the Malawi Longitudinal Study of Families and Health (MLSFH). The results indicate that knowledge of HIV status (1) does not affect chances of divorce for either HIV-negative or HIV-positive respondents; (2) reduces the number of reported sexual partners among HIV-positive respondents; and (3) increases reported condom use with spouses for both HIV-negative and HIV-positive respondents. These results imply that individuals actively respond to information about their HIV status that they learn during HTC, ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Phase composition and microwave dielectric properties of SrTiO3 modified Mg2Al4Si5O18 cordierite ceramics
Publication date: 15 April 2015 Source:Journal of Alloys and Compounds, Volume 628 Author(s): Kaixin Song , Song Wu , Peng Liu , Huixing Lin , Zhihua Ying , Peng Zheng , Weitao Su , Jiangxia Deng , Liang Zheng , Huibin Qin The effects of SrTiO3 addition on phase composition and microwave dielectric properties of cordierite (Mg2Al4Si5O18) ceramics had been investigated in this paper. X-ray diffraction data showed that (1? x)Mg2Al4Si5O18?xSrTiO3|(1? x)MAS? xST (0? x ?0.35)| ceramics presented ?-cordierite solid solution within 0&lt; x ?0.10. In the range of 0.15? x ?0.35, the perovskite-structured SrTiO3 and monoclinic phase of SrAl2Si2O8 feldspar were detected. Rietveld refinement of XRD data showed the shapes of [(Si4Al2)O18] hexagonal rings in (1? x)MAS?xST (0...
The Anatomy of Medical Research US and International Comparisons
Conclusions and RelevanceNew investment is required if the clinical value of past scientific discoveries and opportunities to improve care are to be fully realized. Sources could include repatriation of foreign capital, new innovation bonds, administrative savings, patent pools, and public-private risk sharing collaborations. Given international trends, the United States will relinquish its historical international lead in the next decade unless such measures are undertaken. (Source: JAMA)
Sleep aids: Could antihistamines help me sleep?
(Source: MayoClinic.com - Ask a Specialist)
Treating AIDS: Politics of Difference, Paradox of Prevention. Thurka Sangaramoorthy, New Brunswick: Rutgers University Press, 2014, 198 pp.
(Source: Medical Anthropology Quarterly)
Estimating the size of populations at high risk for HIV using respondent?driven sampling data
This article presents a case?study of the estimation of the size of the hard?to?reach population based on data collected through RDS. We study two populations of female sex workers and men?who?have?sex?with?men in El Salvador. The approach is Bayesian and we consider different forms of prior information, including using the UNAIDS population size guidelines for this region. We show that the method is able to quantify the amount of information on population size available in RDS samples. As separate validation, we compare our results to those estimated by extrapolating from a capture?recapture study of El Salvadorian cities. The results of our case?study are largely comparable to those of the capture?recapture study when they differ from the UNAIDS guidelines. Our meth...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Diagnosing and Managing Diabetes in HIV-Infected Patients: Current Concepts
Diabetes mellitus (DM) is a common condition with significant associated morbidity and mortality. DM diagnosis and management among human immunodeficiency virus (HIV)-infected patients is a particularly relevant topic as the HIV-infected population ages and more HIV-infected individuals live with chronic medical comorbidities. Although there is mixed evidence regarding HIV as an independent risk factor for DM, multiple factors related to HIV and its treatment are associated with DM. This review covers the epidemiology of DM in HIV-infected patients, and diagnosis, management, and treatment goals for DM in HIV-infected patients. We highlight the most recent DM treatment guidelines from the American Diabetes Association and the European Association for the Study of Diabetes, emphasizing indi...
Significant Reduction in HIV Virologic Failure During a 15-Year Period in a Setting With Free Healthcare Access
Conclusions.&nbsp;The proportion of HIV-infected patients experiencing VF during routine care fell markedly between 1997 and 2009&ndash;2011, to only 9.7%. This was attributed to the advent of fully active and better-tolerated antiretroviral drugs, and to national guidelines recommending rapid management of VF after mid-2000. (Source: Clinical Infectious Diseases)
Editorial Commentary: Should Longitudinal Multisite Studies Become the New Standard for Investigating Neurocognitive Functions in HIV Infection?
(Source: Clinical Infectious Diseases)
Mucosal CD4+ T cells and SIV transmission [Immunology and Inflammation]
An effective T-cell?based AIDS vaccine should induce strong HIV-specific CD8+ T cells in mucosal tissues without increasing the availability of target cells for the virus. Here, we evaluated five immunization strategies that include Human adenovirus-5 (AdHu5), Chimpanzee adenovirus-6 (AdC6) or -7 (AdC7), Vaccinia virus (VV), and DNA given by electroporation... (Source: Proceedings of the National Academy of Sciences)
Pediatric Cochlear Implantation in Residual Hearing Candidates.
CONCLUSIONS: CIs provide better results compared with hearing aids in children with residual hearing. Factors that may impact the benefits of CIs in patients with residual hearing are age, delay in performing the CI procedure, which ear is implanted, and initial underestimation of the patient's hearing difficulties. PMID: 25586946 [PubMed - as supplied by publisher] (Source: The Annals of Otology, Rhinology, and Laryngology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
"Bend a Fish When the Fish Is Not Yet Dry": Adolescent Boys' Perceptions of Sexual Risk in Tanzania.
"Bend a Fish When the Fish Is Not Yet Dry": Adolescent Boys' Perceptions of Sexual Risk in Tanzania. Arch Sex Behav. 2015 Jan 13; Authors: Sommer M, Likindikoki S, Kaaya S Abstract Despite decades of effort, the spread of HIV/AIDS continues among many African young people. A key contributor is unsafe sexual behavior that is desired, persuaded, or coerced. We explored the masculinity norms shaping pubescent boys' perceptions of and engagement in (unsafe) sexual behaviors in Tanzania. Through a comparative case study in rural and urban Tanzania, qualitative and participatory methods were used with 160 adolescent boys in and out of school to better understand the social and contextual factors promoting unsafe sexual behaviors. Adolescent boys in both the rural and urban s...
Disneyland: The Latest Victim of the Anti-Vaxxers
Somewhere in Orange County, Mary Poppins may be running a fever. The same could be true for her coworkers&mdash;an unsuspecting Ariel, say; a suddenly swoony Goofy or Pluto or any of the other 23,000 people (OK, or characters) who punch in for work at Disneyland every day. And the same could be true too for any one of the estimated 16 million people who will pour into the theme park this year. The reason? Measles. The cause? This may not come entirely as a surprise: the anti-vaccine crowd. Just when you think they&#8217;ve been run to ground, shamed into silence, and just when you can watch a whole evening of Jenny McCarthy co-hosting the New Year&#8217;s Eve celebration in Times Square and not hear her utter a word of unscientific nonsense, the anti-vaxxers come roaring back. Less than tw...
HIV Care Saves LivesHIV Care Saves Lives
CDC Director Tom Frieden shares the nation's most important strategy to help people with HIV live longer and to end the HIV epidemic. CDC Expert Commentary (Source: Medscape Cardiology Headlines)
NLM HIV/AIDS Portal Offers Multilingual Content Search
NLM's HIV/AIDS Portal now offers users the ability to search for multilingual content. The new Multilingual Search interface searches specifically for HIV/AIDS related topics from the multilingual and multicultural content of HealthReach (formerly RHIN). (Source: PHPartners.org)
South Africa: South African HIV Program On Rights of Sex Workers
[Global Fund]The South African National AIDS Council said that a long-awaited HIV program catering specifically to the needs of sex workers - 60 percent of whom are estimated to be living with HIV - became firmly established during the course of 2014. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Brain protein aids influenza recovery, scientists find
A brain protein that boosts the healing power of sleep and speeds an animal's recovery from the flu has been discovered by researchers who say that the discovery could lead to alternative treatments for influenza and other infectious diseases, possibly by using intranasal sprays to stimulate the production of the brain protein, called AcPb. (Source: ScienceDaily Headlines)
Occupationally Acquired HIV: Healthcare Workers' Risk LowOccupationally Acquired HIV: Healthcare Workers' Risk Low
Occupational-related HIV transmission has been confirmed in only 58 healthcare workers since 1985. Medscape Medical News (Source: Medscape Hiv-Aids Headlines)
Zambia: Japan Gives K3.8 Million for HIV-Aids Fight
[Times of Zambia]JAPAN has signed a grant contract with Association for Aid and Relief (AAR) to facilitate the implementation of an HIV/AIDS project in Kafue and Chilanga districts. (Source: AllAfrica News: HIV-Aids and STDs)
South Africa: Study Links Birth Control to Increased Risk of HIV Infection
[Health-e]Women using the birth control shot known by the brand name Depo-Provera may have about a 30 percent higher risk of contracting HIV, according to new research. However, the link between hormonal contraception and HIV remains uncertain. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: As National HIV Counselling and Testing Campaign Commences
[Leadership]Winifred Ogbebo writes on the current HIV counselling and testing being conducted nationwide to enable Nigerians know their status (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Africa: Pepfar Pumps U.S $ 210 Million in Africa
[Times of Zambia]THE United States through its President's Emergency Plan For AIDS Relief (PEPFAR) has set aside US $210 million for the Accelerated Children's HIV/AIDS Treatment (ACT) for children living with HIV in Sub-Saharan Africa. (Source: AllAfrica News: HIV-Aids and STDs)
WSU scientists find brain protein aids influenza recovery
(Washington State University) Washington State University Spokane scientists have found a brain protein that boosts the healing power of sleep and speeds an animal's recovery from the flu.Krueger said the discovery could lead to alternative treatments for influenza and other infectious diseases, possibly by using intranasal sprays to stimulate the production of the brain protein, called AcPb. (Source: EurekAlert! - Medicine and Health)
Findings from the Women of Color HIV Initiative published in AIDS Patient Care and STDs journal
(Mary Ann Liebert, Inc./Genetic Engineering News) African Americans currently account for nearly half of all new HIV diagnoses, and among females, 64 percent of new HIV diagnoses affect Black/African American women. A series of articles reporting results from the Women of Color HIV Initiative, including topics such as linkage and barriers to care, treatment adherence, viral suppression, substance abuse, and violence, are published in a special issue of AIDS Patient Care and STDs. (Source: EurekAlert! - Social and Behavioral Science)
Effectiveness of low vision services in improving patient quality of life at Aravind Eye Hospital
Conclusion: Low vision services and visual aids can improve the quality of life in South Indian rural population regardless of age, gender, and education level. Thus, all low vision patients who meet the criteria should be referred for evaluation. (Source: Indian Journal of Ophthalmology)
Pharmacokinetics and safety of rifabutin in young HIV-infected children receiving rifabutin and lopinavir/ritonavir
Conclusions Rifabutin dosed at 5 mg/kg three times per week resulted in lower AUC0&ndash;48, AUC0&ndash;24 and Cmax values for rifabutin and 25-O-desacetyl rifabutin compared with adults receiving 150 mg of rifabutin daily, the current recommended dose. We observed high rates of severe transient neutropenia, possibly due to immaturity of CYP3A4 in young children. It remains unclear whether a safe and effective rifabutin dose exists for treatment of TB in children receiving lopinavir/ritonavir. (Source: Journal of Antimicrobial Chemotherapy)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
?Don?t step on Tony!? The importance of symptoms when working with psychosis.
This article claims that the attention to a patient?s symptoms is critical when working with psychotic states. It asserts that viewing symptoms as a crucial inroad into the understanding of the patient?s issues is often disregarded in today?s mental health environment, which focuses almost exclusively on the elimination of symptoms with medication. The authors regard symptoms as presenting a vital inroad into the working relationship with persons suffering psychosis. A detailed case illustration is presented to demonstrate the way working with symptoms gives credibility to the patient?s reality and aids in creating a working alliance and in moving the treatment forward. (PsycINFO Database Record (c) 2015 APA, all rights reserved) (Source: Psychoanalytic Psychology)
AIDS, activism and access.
Authors: McSorley T PMID: 25583672 [PubMed - as supplied by publisher] (Source: cmaj)
Frequency modulation systems in hearing impaired children: outcome evaluation
CONCLUSION: The use of subjective measures, such as the questionnaire, it is essential to determine the indication of the effectiveness of assistive devices for the hearing impaired. The effectiveness of the system could be observed by FM "FM advantage," which is the average difference of 10 dB minimum found in the evaluations of speech perception with and without FM noise in different situations. The benefits found in this study using the FM system in the improvement of speech perception can be extrapolated not only to the classroom and to laws of inclusive education, but also for social and recreational activities. (Source: Revista da Sociedade Brasileira de Fonoaudiologia)
Auditory and language abilities in children with cochlear implants who live in bilingual homes: a cases report
O implante coclear (IC) tem sido indicado para crianças deficientes auditivas de grau severo e/ou profundo que não tem benefício com o aparelho de amplificação sonora individual (AASI), e que apresentem família adequada e motivada para o uso do dispositivo, bem como condições adequadas de reabilitação na cidade de origem. Atualmente, a procura pelo IC também ocorre por pais surdos, fluentes na Língua Brasileira de Sinais (LIBRAS), que recorrem a este tratamento para oferecer outra realidade para seus filhos. O ambiente destas crianças é bilíngue, dado pela LIBRAS dos pais e pela linguagem oral dos familiares próximos, do fonoaudiólogo e da escola. Neste sentido, o presente estudo visou acompanhar quatro crianças deficientes auditivas implantadas, sendo duas crianças filh...
Development of a Psychosocial Distress Measure for Ugandan Adolescents Living with HIV

Policies directed towards STD/AIDS and their political-care integration in the context of the SUS: a study of the city of Florianópolis, SC, Brazil
This qualitative study, with a socio-historical perspective, aimed to examine how the process of decentralization of STD/AIDS actions took place in Florianópolis, SC, Brazil, and its effects on the level of care and administration. The data collection was based on documentary and oral sources. A total of 11 health professionals were interviewed, who performed care and/or management activities linked to STD/AIDS, during the study period (2006-2010). The results were analyzed using content analysis, resulting in two categories: The administrative decentralization of the Municipal STD/AIDS Program; The decentralization of STD/AIDS care. The restructuring of the STD/AIDS Program was part of the reorganization process of the municipal health system and the progressive incorporation of the conc...
Blue light aids in coping with the post-lunch dip: an EEG study - Baek H, Min B.
The 'post-lunch dip' is a commonly experienced period of drowsiness in the afternoon hours. If this inevitable period can be disrupted by an environmental cue, the result will be enhanced workplace performance. Because blue light is known to be a critical ... (Source: SafetyLit: All (Unduplicated))
Zambia: Zambia and Global Fund Sign U.S.$234 Million in New Grants
[Global Fund]Lusaka -The Government of the Republic of Zambia, the Churches Health Association of Zambia, and the Global Fund today reaffirmed their partnership, signing four new grants worth US$234 million to fight HIV, TB and malaria in Zambia. (Source: AllAfrica News: HIV-Aids and STDs)
HIV-1 Nef: A Master Manipulator of the Membrane Trafficking Machinery Mediating Immune Evasion
Conclusion : The extensive interaction network formed between Nef and numerous membrane trafficking regulators suggests that Nef?s role in evading the immune surveillance system intersects multiple host membrane trafficking pathways. Significance : Nef?s ability to evade the immune surveillance system is linked to AIDS pathogenesis. Thus, a complete understanding of the molecular pathways that are subverted by Nef in order to downregulate MHC-I will enhance our understanding of HIV-1?s progression to AIDS. (Source: Biochimica et Biophysica Acta (BBA) General Subjects)
HIV/AIDS and rheumatoid arthritis
The objective of this review was to identify possible interferences of HIV infection in the diagnosis and management of rheumatoid arthritis (RA). A review of the available evidence was conducted using the GRADE approach. Overall, the quality of evidence was low. Our main conclusions were: (1) the occurrence of rheumatoid-like arthritis in patients with HIV/AIDS is quite rare; therefore, it is not recommended that HIV infection be considered routinely as a differential diagnosis in this condition (C2); (2) HIV infection may lead to rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibody positivity, but usually at low titers (C1); (3) RA might cause false-positive HIV serology and ELISA seems to be a more specific test for HIV in patients with RA (C2); (4) RA and AI...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
HIV-1 Nef: A Master Manipulator of the Membrane Trafficking Machinery Mediating Immune Evasion.
CONCLUSION:: The extensive interaction network formed between Nef and numerous membrane trafficking regulators suggests that Nef's role in evading the immune surveillance system intersects multiple host membrane trafficking pathways. SIGNIFICANCE:: Nef's ability to evade the immune surveillance system is linked to AIDS pathogenesis. Thus, a complete understanding of the molecular pathways that are subverted by Nef in order to downregulate MHC-I will enhance our understanding of HIV-1's progression to AIDS. PMID: 25585010 [PubMed - as supplied by publisher] (Source: Biochimica et Biophysica Acta)
Argos HIV Drug Misses Main Goal in Mid-Stage StudyArgos HIV Drug Misses Main Goal in Mid-Stage Study
Argos Therapeutics Inc said its experimental immunotherapy was unsuccessful in treating HIV-infected patients, raising doubts about its technology platform and sending its stock plunging as much as 31% on Friday. Reuters Health Information (Source: Medscape Medical News Headlines)
From Vertigo to Tinnitus, Ear Ailments Are New Focus for Drugs
In search of an alternative to hearing aids or implants, some report success in early trials for drugs to improve hearing or silence tinnitus. (Source: NYT Health)
Depo-Provera Linked to Higher HIV Risk, Researchers Find
Whether 'birth control shot' increases risk or if risk is from less condom use isn't clear, expert says Source: HealthDay Related MedlinePlus Pages: Birth Control, HIV/AIDS in Women, International Health (Source: MedlinePlus Health News)
South Sudan: Aids-Related Deaths Rise Among People Affected By Conflict
[PR Newswire]Juba, South Sudan -As the world commemorated World AIDS Day on December 1, South Sudan health partners reported an increase in AIDS-related deaths among displaced people, mainly due to complications related to disrupted treatment or limited access to treatment. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
South Sudan: South Sudan Humanitarian Bulletin - Highlights
[PR Newswire]Juba, South Sudan -AIDS-related deaths are on the rise among conflict affected people. (Source: AllAfrica News: HIV-Aids and STDs)
Macrothrombocytopenia in North India: Role of Automated Platelet Data in the Detection of an Under Diagnosed Entity
Abstract Congenital macrothrombocytopenia is being increasingly recognised because of the increasing availability of automated platelet counts during routine complete blood count. If not recognised, these patients may be unnecessarily investigated or treated. The study was done to assess the occurrence of macrothrombocytopenia in the North Indian population and the role of automated platelet parameters in its detection. This prospective study was done on patients whose blood samples were sent for CBC to the hematology laboratory of a tertiary care hospital. Samples were run on Advia-120, a 5-part differential automated analyzer. Routine blood parameters including platelet count, mean platelet volume (MPV), platelet cytogram pattern and platelet flagging was studied along with per...
Depo-Provera Linked to Increased HIV Risk in AfricaDepo-Provera Linked to Increased HIV Risk in Africa
A meta-analysis showed a link between depot medroxyprogesterone acetate use and increased relative risk for HIV infection among women in sub-Saharan Africa. Medscape Medical News (Source: Medscape Medical News Headlines)
Nigeria: Association Blames Discrimination for Death of HIV Victims
[Independent (Lagos)]The Association of Women Living with HIV/AIDS in Nigeria (ASWHAN) has blamed the large number of death recorded among AIDS victims to discrimination. (Source: AllAfrica News: HIV-Aids and STDs)
OXYGEN, REFRIGERATED (Oxygen) Gas [Patient Aids, Inc. Dba Home Respiratory Service]
Updated Date: Jan 9, 2015 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Risk factors for HIV infection among circumcised men in Uganda: a case-control study.
CONCLUSIONS: Being circumcised at adulthood, resumption of sexual intercourse before wound healing, inconsistent condom use and having sex under the influence of peers were significant risk factors for HIV infection. Risk reduction messages should address these risk factors, especially among traditionally circumcised men. PMID: 25556374 [PubMed - in process] (Source: Journal of the International AIDS Society)
Socioeconomic Gradients in Internalized Stigma Among 4,314 Persons with HIV in Sub-Saharan Africa
In this study, I apply a novel method to data from the Demographic and Health Surveys to identify persons with HIV who were aware of their seropositivity at the time of the survey. The pooled dataset includes 4,314 persons with HIV in Cameroon, Ethiopia, Gabon, Kenya, Lesotho, Malawi, Rwanda, Swaziland, Tanzania, Uganda, Zambia, and Zimbabwe. My findings indicate that nearly one-fifth of study participants provided survey responses consistent with internalization of stigmatizing beliefs. Furthermore, in multivariable regression models, striking socioeconomic gradients in internalized stigma were observed. A clear implication of my findings is that the adverse health and psychosocial impacts of HIV stigma are likely concentrated among those with the fewest socioeconomic resources for man...
Tissue expression of TGF-?1 in uterine cervical samples from HIV/AIDS patients
Publication date: July 2012 Source:Microbial Pathogenesis, Volume 53, Issue 1 Author(s): Thiago X. Carneiro , Juliana T. Pacheco , Marilia B. Xavier , Juarez A.S. Quaresma Case-control study based on the immunohistochemistry for TGF-?1 evaluation of cervical samples obtained from two groups of women: CIN/HIV? and CIN/HIV+. Eleven women infected with HIV and with a histopathological diagnosis of CIN were included. The control group consisted of 12 patients with CIN. Cervical tissue samples obtained from all patients were submitted to histopathology and semiquantitative analysis of immunostaining for TGF-?1 protein. In addition, the peripheral CD4+ cell count and viral load were evaluated in HIV + patients. Tissue expression of the cytokine was higher in the CIN/HIV+ group compared t...
HIV-1 nucleocapsid and ESCRT-component Tsg101 interplay prevents HIV from turning into a DNA-containing virus
HIV-1, the agent of the AIDS pandemic, is an RNA virus that reverse transcribes its RNA genome (gRNA) into DNA, shortly after its entry into cells. Within cells, retroviral assembly requires thousands of structural Gag proteins and two copies of gRNA as well as cellular factors, which converge to the plasma membrane in a finely regulated timeline. In this process, the nucleocapsid domain of Gag (GagNC) ensures gRNA selection and packaging into virions. Subsequent budding and virus release require the recruitment of the cellular ESCRT machinery. Interestingly, mutating GagNC results into the release of DNA-containing viruses, by promo-ting reverse transcription (RTion) prior to virus release, through an unknown mechanism. Therefore, we explored the biogenesis of these DNA-containing particl...
High-resolution genetic analysis of the requirements for horizontal transmission of the ESBL plasmid from Escherichia coli O104:H4
Horizontal dissemination of the genes encoding extended spectrum beta-lactamases (ESBLs) via conjugative plasmids is facilitating the increasingly widespread resistance of pathogens to beta-lactam antibiotics. However, there is relatively little known about the regulatory factors and mechanisms that govern the spread of these plasmids. Here, we carried out a high-throughput, transposon insertion site sequencing analysis (TnSeq) to identify genes that enable the maintenance and transmission of pESBL, an R64 (IncI1)-related resistance plasmid that was isolated from Escherichia coli O104:H4 linked to a recent large outbreak of gastroenteritis. With a few exceptions, the majority of the genes identified as required for maintenance and transmission of pESBL matched those of their previously def...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Depo-Provera Linked to Higher HIV Risk, Researchers Find
Whether 'birth control shot' increases risk or if risk is from less condom use isn't clear, expert says (Source: Fertility News - Doctors Lounge)
The value of the systematic inflammation-based Glasgow Prognostic Score in patients with gastric cancer: A literature review
Yongyin Gao, Dingzhi HuangJournal of Cancer Research and Therapeutics 2014 10(4):799-804The presence of a systemic inflammatory response (SIR) is recognized to occur in the presence of malignancy. And the SIR-Glasgow Prognostic Score (GPS)/modified GPS (mGPS) composed of the C-reactive protein (CRP) and albumin is a tumor stage- and treatment-independent, routinely available and well-standardized prognostic factor, reflects both an ongoing SIR (CRP) and a progressive nutritional decline (albumin) in patients with advanced cancer. Previous studies showed that GPS/mGPS appear to be a superior prognostic factor compared with other cellular components of the SIR and Eastern Cooperative Oncology Group performance status in some aspects. Besides, GPS/mGPS aids at deciding active or palliation tr...
Malondialdehyde, superoxide dismutase and melatonin levels in GCF of aggressive and chronic periodontitis patients
ConclusionMDA, melatonin and SOD could be considered as biomarkers for oxidative stress in periodontal diseases and might be useful diagnostic aids in distinguishing CP and GAgP patients.This article is protected by copyright. All rights reserved. (Source: Australian Dental Journal)
Human Immunodeficiency Virus (HIV)-1 Integration Sites in Viral Latency
Abstract The persistence of human immunodeficiency virus type 1 (HIV-1) in latent reservoirs is a major barrier to HIV cure. Reservoir establishment depends on low viral expression that may be related to provirus integration sites (IS). In vitro, in cell lines and primary T cells, latency is associated with specific IS through reduced viral expression mediated by transcriptional interference by host cellular promoters, reverse orientation, and the presence of specific epigenetic modifiers. In primary T cell models of latency, specific IS are associated with intracellular viral antigen expression that is not directly related to cell activation. In contrast, in patient CD4+ T cells, there is enrichment for IS in genes controlling cell cycle and survival and in some clonally expanded...
Network Influences on the Sexual Risk Behaviors of Gay, Bisexual and Other Men Who Have Sex with Men Using Geosocial Networking Applications

mHealth Technology as a Persuasive Tool for Treatment, Care and Management of Persons Living with HIV
Abstract Mobile health (mHealth) technology can be a valuable tool in the management of chronic illnesses, including HIV. Qualitative research methods were used to identify the desired content and features of a mobile app for meeting and improving the healthcare needs of persons living with HIV (PLWH). We conducted six focus group sessions with 50 English-or Spanish-speaking PLWH in New York City. To inform data analysis and to illustrate how mHealth technology can be used as a persuasive strategy for improving the health of PLWH, we integrated Fogg?s functional role triad for computing technology model with the self-determination theory to illustrate how mHealth technology can be used as a persuasive strategy for improving the health of PLWH. Participants suggested several tool...
The Relationship Between Online Social Network Use, Sexual Risk Behaviors, and HIV Sero-Status Among a Sample of Predominately African American and Latino Men Who have Sex with Men (MSM) Social Media Users
This study sought to compare use of online social networking sites (SNSs) and sexual risk behaviors between HIV(+) and HIV(?) individuals among a sample of predominately African American and Latino SNS-using MSM. A total of 112 MSM Facebook users were recruited online and offline and completed an online survey. We performed regression models to assess the association between HIV status, SNS use, and sexual risk behaviors. After adjusting for age, race, and employment status, being HIV positive was significantly associated with a greater number of sexual partners (ARR = 2.84, p = 0.0017) and lower comfort levels of discussing HIV/STI status on SNSs (AOR: 0.23, p = 0.011). Findings suggest that HIV status is associated with sexual risk behaviors and SNS use among SNS-using MSM. We di...
Antiretroviral Therapy Adherence and Use of an Electronic Shared Medical Record Among People Living with HIV
Abstract Electronic shared medical records (SMR) are emerging healthcare technologies that allow patients to engage in their healthcare by communicating with providers, refilling prescriptions, scheduling appointments, and viewing portions of medical records. We conducted a pre-post cohort study of HIV-positive adults who used and did not use SMR in two integrated healthcare systems. We compared the difference in antiretroviral refill adherence between SMR users and age- and sex-frequency matched non-users from the 12-month period prior to SMR useto the 12-month period starting 6 months after initiation of SMR use. High adherence was maintained among SMR users (change = ?0.11 %) but declined among non-users (change = ?2.05 %; p = 0.003). Among SMR users, there was a s...
Gay Apps for Seeking Sex Partners in China: Implications for MSM Sexual Health
Abstract Anti-gay stigma and harsh local environments in many low and middle-income countries (LMIC) encourage men who have sex with men (MSM) partner-seeking mobile application (gay app) use. To investigate the sexual risk profiles of gay app users and guide future HIV prevention programs, we conducted a cross-sectional online survey among 1,342 MSM in China examining associations between gay app use and sexual behaviors, including HIV and sexually transmitted disease testing. Compared to non-app users, app users were more likely to be younger, better educated, ?out? about their sexual orientation, and single. They were also more likely to report multiple recent sex partners and HIV testing, but there was no difference in condomless sex between the two groups. Future research...
The Relationship Between ART Adherence and Smoking Status Among HIV+ Individuals
We examined smoking and ART adherence among 203 HIV+ individuals enrolled in a randomized trial of interventions to increase ART adherence. Prior analyses indicated there were no overall treatment group effects. Smoking status and motivation to quit was assessed at baseline and ART adherence was assessed at week 12, 24, 36, and 48. Longitudinal generalized estimating equation analysis that controlled for treatment group revealed that smoking status was not significantly related to adherence over time. Motivation to quit was high with 58 % intending to quit in the next 6 months and 25 % intending to quit in the next 30 days. Findings suggest that smoking is not associated with adherence among those with adherence difficulties. However it does not diminish importance of addressing both b...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Cote d'Ivoire: Addressing Inequality Is Major Health Challenge of Our Time
[Key Correspondents]Prisca, 36, was diagnosed with HIV three years ago, but as an unemployed mother of two, she is more concerned about feeding her children than getting HIV treatment. (Source: AllAfrica News: HIV-Aids and STDs)
Impact of Prophylactic Mastectomy in BRCA1/2 Mutation Carriers
Unlike the general decrease in invasive oncologic care, the trend for prophylactic bilateral mastectomy in healthy women and prophylactic contralateral mastectomy in women with unilateral breast cancer is steadily rising. This is even more surprising when considering that for e.g. prophylactic contralateral mastectomy no clear survival benefit has been demonstrated so far. The decision-making process around risk-reducing surgery may be influenced by several conflicting parameters such as the patient's fears and desire to achieve a survival advantage, the surgeon's financial motivations, or the oncologist's paternalistic approach to the above trend. Physicians should support their patients throughout the decision-making process, guide them through the dense fog of information, and encourage...
Nigeria: Govt Adopts New Funding Model of Global Funds
[Guardian]Abuja -NIGERIA has adopted the new funding model of the Global Fund to Fight AIDS, Tuberculosis and Malaria that allows the international organization to invest more strategically, achieve greater impact, and engage implementers and partners more effectively. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: In 2015, Accelerating Progress Toward an AIDS-Free Generation
[State Department]This blog post by U.S. Global AIDS Coordinator Deborah L. Birx originally appeared on the State Department website on January 6. Ambassador Birx oversees the implementation of the U.S. President's Emergency Plan for AIDS Relief (PEPFAR). (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: Nigeria to Record More HIV Deaths, Infections in 2015-Expert
[Independent (Lagos)]Abuja -Nigeria will experience a sharp increase HIV related deaths, more infections will show up and even as the number of those in need of HIV related services and treatment will increase in 2015, if the federal government fails to fill the gap left by the foreign donors who have since withdrawn their services. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Botswana: Testing Together Reduces Risks
[Botswana Daily News]Tsabong -Couples who test for HIV/AIDS together develop a joint risk reduction plan to positively support each other throughout, says an official of Tebelopele Voluntary Counselling and Testing Centre in Tsabong. (Source: AllAfrica News: HIV-Aids and STDs)
Polls of Future Past: A History of Public Expectations for the Future of Science
Science fiction sometimes barely beats out science fact as technological advancements rapidly transform the world. But the changes that are anticipated aren't always the ones that arrive. Here's a look back at what the polls tell us the public has expected from scientific progress -- and how often they've been disappointed. From the Roper Center for Public Opinion Research archives: Reality Outpacing Expectations: The Moon Landing When Gallup first asked Americans in 1949 whether they expected man to reach the Moon in the next 50 years, only 15 percent said yes. Despite the shocking power of new wartime technologies like the atom bomb, the public remained skeptical about the idea of space travel. Just six years later the proportion saying man would be on the Moon in 50 years more than do...
Zimbabwe: Nurse Escapes Jail for Faking HIV Results
[New Zimbabwe]A GOKWE nurse who connived with a health NGO worker employed by Global Fund to fake results of an HIV test in favour of the nurse's husband on Tuesday was lucky to escape jail after she was handed a non-custodial sentence. (Source: AllAfrica News: HIV-Aids and STDs)
The availability of alternative devices for the management of the difficult airway in public emergency centres in the Western Cape
Discussion The study demonstrated that Western Cape public emergency centres are currently inadequately stocked with regard to alternative airway devices. A guideline regarding the procurement and implementation of these devices is needed. (Source: African Journal of Emergency Medicine)
Retention in HIV Care Among Female Sex Workers in the Dominican Republic: Implications for Research, Policy and Programming
This study described factors from Andersen?s behavioral model that were associated with retention in HIV care among 268 female sex workers (FSWs) living with HIV in the Dominican Republic using two measures of retention: a 6-month measure of HIV clinic attendance and a measure that combined clinic attendance and missed visits. FSWs who ever attended HIV care reported high rates (92 %) of 6-month attendance, but 37 % reported missed visits. Using the combined retention measure, the odds of being retained in HIV care were higher among FSWs with more positive perceptions of HIV service providers [adjusted odds ratio (AOR) 1.17; 95 % confidence interval (CI) 01.09, 1.25] and lower among women who reported recent alcohol consumption (AOR 0.50; 95 % CI 0.28, 0.92) and self-stigmatizing bel...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Social Media Use and High-Risk Sexual Behavior Among Black Men Who Have Sex with Men: A Three-City Study
Abstract Black men who have sex with men (MSM) bear a disproportionate burden of human immunodeficiency (HIV) incidence in the United States. Little research has focused on the associations between social media use and sexual behavior among Black MSM. 205 Black MSM completed measures assessing social media use and sexual behaviors. Men spent an average of 34 h per week on social media sites. 53 % arranged sexual hookups online in the previous 3 months, and did so a mean of 10 times. Overall, users of social media and men who arranged sexual hookups online engaged in more risky behaviors than non-users and men who did not arrange sexual hookups online. However, partner-level data indicated that men engaged in fewer risky behaviors with partners met online compared to partners me...
Enhancing Lay Counselor Capacity to Improve Patient Outcomes with Multimedia Technology
Abstract Multimedia technologies offer powerful tools to increase capacity of health workers to deliver standardized, effective, and engaging antiretroviral medication adherence counseling. Masivukeni?is an innovative multimedia-based, computer-driven, lay counselor-delivered intervention designed to help people living with HIV in resource-limited settings achieve optimal adherence. This pilot study examined medication adherence and key psychosocial outcomes among 55 non-adherent South African HIV+ patients, on antiretroviral therapy (ART) for at least 6 months, who were randomized to receive either Masivukeni or standard of care (SOC) counseling for ART non-adherence. At baseline, there were no significant differences between the SOC and Masivukeni groups on any outcome va...
An Aggressive Plasmablastic Lymphoma of the Oral Cavity as Primary Manifestation of Acquired Immunodeficiency Syndrome: Case Report and Literature Review
Conclusion?The HIV serologic status should be evaluated in all patients with plasmablastic lymphoma of the oral cavity or extraoral sites.[...]Thieme Publicações Ltda Rio de Janeiro, BrazilArticle in Thieme eJournals:Table of contents  |  Abstract  |  open access Full text (Source: International Archives of Otorhinolaryngology)
HIV/AIDS policy-making in Kyrgyzstan: a stakeholder analysis
This article explores the main actors in HIV/AIDS policy-making, their interests, support and involvement and their current ability to set the agenda and influence the policy-making process. Fifty-four semi-structured interviews were conducted in the autumn of 2011, complemented by a review of policy documents and secondary sources on HIV/AIDS in Kyrgyzstan. We found that most stakeholders were supportive of progressive HIV/AIDS policies, but that their influence levels varied considerably. Worryingly, several major state agencies exhibited some resistance or lack of initiative towards HIV/AIDS policies, often prompting international agencies and local NGOs to conceptualize and drive appropriate policies. We conclude that, without clear vision and leadership by the state, the sustainabilit...
Challenges with the implementation of an Integrated Disease Surveillance and Response (IDSR) system: systematic review of the lessons learned
Conclusions The challenges identified with IDSR implementation are largely &lsquo;systemic&rsquo;. IDSR will best benefit from skill-based training of personnel and strengthening of the support surveillance functions alongside health care infrastructures at the district level. (Source: Health Policy and Planning)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Russian nursing students¿ knowledge level and attitudes in the context of human immunodeficiency virus ( HIV ) ¿ a descriptive study
Conclusions: Given that the HIV epidemic in Russia is both substantial and increasing, it is essential to improve HIV nursing education to provide sufficient and up-to-date information about HIV and also to prepare nursing students for caring for PLWHA. In doing so, this may help to address both the deficits in student knowledge, and also modify their attitude towards PLWHA. (Source: BMC Nursing)
Electronic Nicotine Delivery Systems: A Policy Statement from the American Association for Cancer Research and the American Society of Clinical Oncology.
Authors: Brandon TH, Goniewicz ML, Hanna NH, Hatsukami DK, Herbst RS, Hobin JA, Ostroff JS, Shields PG, Toll BA, Tyne CA, Viswanath K, Warren GW Abstract Combustible tobacco use remains the number one preventable cause of disease, disability, and death in the United States. Electronic nicotine delivery systems (ENDS), which include e-cigarettes, are devices capable of delivering nicotine in an aerosolized form. ENDS use by both adults and youth has increased rapidly, and some have advocated these products could serve as harm-reduction devices and smoking cessation aids. ENDS may be beneficial if they reduce smoking rates or prevent or reduce the known adverse health effects of smoking. However, ENDS may also be harmful, particularly to youth, if they increase the likelihood that no...
Africa: Promise of the Future - Life After HIV/Aids Pandemic, Other Issues
[Guardian]AMONG the pandemics that afflicted mankind in recent memory HIV/AIDS is perhaps the one with the longest and lasting span of life. While campaigns against it may appear muted for now, it does not mean the pandemic is over. It just means that there are new ways of looking at it. While HIV/AIDS may not be the overnight killer it was a few years ago, knowledge through accurate information about it is still key to beating it. (Source: AllAfrica News: HIV-Aids and STDs)
Smart Hearing Aids from Siemens Use easyTek App Control
At the 2015 International CES, Siemens is unveiling smart hearing aids - their latest in wearable hearing technology. (Source: Disabled World)
South Africa: Drinking, Smoking and TB
[Health-e]Grace Shabangu has been drinking and smoking more than half her life, will developing tuberculosis (TB) give her the will to change? (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
[Editors' Choice] Senescent Cells Promote Tissue Repair
Release of the growth factor PDGF-AA from senescent cells at skin wounds aids in healing. (Source: Signal Transduction Knowledge Environment)
Genome-wide association study of virologic response with efavirenz-containing or abacavir-containing regimens in AIDS clinical trials group protocols
BackgroundEfavirenz and abacavir are components of recommended first-line regimens for HIV-1 infection. We used genome-wide genotyping and clinical data to explore genetic associations with virologic failure among patients randomized to efavirenz-containing or abacavir-containing regimens in AIDS Clinical Trials Group (ACTG) protocols. Participants and methodsVirologic response and genome-wide genotype data were available from treatment-naive patients randomized to efavirenz-containing (n=1596) or abacavir-containing (n=786) regimens in ACTG protocols 384, A5142, A5095, and A5202. ResultsMeta-analysis of association results across race/ethnic groups showed no genome-wide significant associations (P (Source: Pharmacogenetics and Genomics)
Broad immune response may be needed to destroy latent HIV
(Yale University) A major barrier to finding a cure for HIV/AIDS is the presence of latent HIV in the cells of chronically infected individuals. But a team of Yale and Johns Hopkins researchers may have pinpointed a strategy for eliminating the residual virus. (Source: EurekAlert! - Infectious and Emerging Diseases)
The impact of orphanhood on education attendance: evidence from Zimbabwe
Publication date: January 2015 Source:International Journal of Educational Development, Volume 40 Author(s): Wei Ha , Peter Salama , Stanley Gwavuya The development community has started to question the exclusive focus of social protection programmes on orphans and vulnerable children affected by AIDS in the context of widespread poverty and vulnerability in Africa. This paper, using 2009 Zimbabwe Multiple Indicator Monitoring Survey data and multivariate regression analysis and simulations, shows that the impact of orphan-hood on children's access to education should be not underestimated. Specifically, the probability differential of dropping out of school, when comparing double-orphans and children with both their parents, is almost as large as the gap between a child from the fourth ...
One?Step Synthesis of Single?Layer MnO2 Nanosheets with Multi?Role Sodium Dodecyl Sulfate for High?Performance Pseudocapacitors
A template?free, one?step and one?phase synthesis of single?layer MnO2 nanosheets has been developed via a redox reaction between KMnO4 and sodium dodecyl sulfate (SDS). The successful formation of single?layer MnO2 nanosheets has been confirmed by the characteristic absorption around 374 nm and the typical thickness of ~0.95 nm. The slow redox reaction controlled by the gradual hydrolysis of SDS is found to be the key factor for the successful formation of single?layer nanosheets. SDS not only serves as the precursor of dodecanol to reduce KMnO4, but also aids the formation of single?layer MnO2 nanosheets as a structure?inducing agent. The resultant single?layer MnO2 nanosheets possess superior specific capacitance, which can be attributed to the extended surface and hig...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Knowledge, self-efficacy, and self-perceived risk for cardiovascular disease among Asians living with HIV: The influence of HIV stigma and acculturation
Cardiovascular disease (CVD) and acute coronary syndrome (ACS) have become major health concerns for people living with HIV (PLWH) as life expectancy has increased with antiretroviral therapy. Studies suggest motivation to seek health care is associated with knowledge, self-efficacy to engage in the health care system, and self-perceived risks for CVD and ACS. Using cross sectional data collected from 67 un-/under-insured Asian PLWH in California, we explored the levels of knowledge about CVD, self-efficacy for recognizing ACS symptoms and seeking health care, and self-perceived risk for CVD and ACS, and how HIV stigmatization and acculturation predict these three constructs. (Source: Journal of the Association of Nurses in AIDS Care)
3D Surgical Planning in Patients affected by Lipodystrophy
HIV or AIDS is a disease that has spread in recent years. Thanks to advances in medication control, it is now considered a chronic illness rather than a fatal disease. The introduction of antiretroviral therapies (ART) has significantly reduced mortality and infection rates in patients affected by the human immunodeficiency virus (HIV). Anti-retroviral drugs have reduced the viral load to undetectable levels, allowing patients to lead normal lives. However, one of the side effects of AIDS treatment is the marked lipodystrophy [1,2] it can cause in several parts of the body. (Source: Computerized Medical Imaging and Graphics)
Lessons learnt from coordinating emergency health response during humanitarian crises: a case study of implementation of the health cluster in northern Uganda
Conclusions: The implementation of the health cluster approach in the northern Uganda and other humanitarian crises in Africa highlights a few issues which are important for strengthening health coordination in similar settings. While health clusters are often welcome during humanitarian crises because they have the possibility to improve health coordination, their potential to create an additional layer of bureaucracy into already complex and bureaucratic humanitarian response architecture is a real concern. Although anecdotal evidence has showed that implementation of the humanitarian reforms and the roll out of the cluster approach did improve humanitarian response in northern Uganda; it is critical to establish a mechanism for measuring the direct impact of health clusters on improving...
Noncommunicable Diseases
Semin Reprod Med 2015; 33: 035-040DOI: 10.1055/s-0034-1395277Noncommunicable diseases (NCDs), long considered diseases of little significance to global health, represent the greatest threat to economic development and human health. The main NCDs?diabetes, cancer, cardiovascular disease, and chronic respiratory disease?are the world's number one killer and bear the greatest burden on the poor. On September 19?20, 2011, the United Nations General Assembly (UNGA) convened a high-level meeting (HLM) on the Prevention and Control of Non-Communicable Diseases. The only other HLM held on a health issue in the past had been in 2001 for HIV/AIDS and resulted in ambitious targets, global surveillance, and billions of dollars in aid. The 2011 HLM for NCDs did not measure up to the previous meet...
Please continue to support our work in Africa to combat HIV/AIDS.
Authors: Landsberg-Lewis I Abstract The Stephen Lewis Foundation ( www.stephenlewisfoundation.org ) works with community-level organisations to turn the tide of HIV/AIDS in Africa by providing care and support to women, orphaned children, grandmothers and people living with HIV/AIDS. Since 2003, we have funded more than 1,100 initiatives, partnering with 300 organisations in the 15 African countries hardest hit by the pandemic. PMID: 25563119 [PubMed - in process] (Source: Nursing Standard)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Exposure to Theory-Driven Text Messages is Associated with HIV Risk Reduction Among Methamphetamine-Using Men Who have Sex with Men
Abstract Fifty-two non-treatment-seeking methamphetamine-using men who have sex with men were enrolled in Project Tech Support, an open-label pilot study to evaluate whether exposure to theory-based [social support theory (SST), social cognitive theory (SCT), and health belief model (HBM)] text messages could promote reductions in HIV sexual risk behaviors and/or methamphetamine use. Multivariable analyses revealed that increased relative exposure to HBM or SCT (vs. SST) text messages was associated with significant reductions in the number of HIV serodiscordant unprotected (i.e., without a condom) anal sex partners, engagement in sex for money and/or drugs, and frequency of recent methamphetamine use; additionally, increased relative exposure to HBM (vs. SCT or SST) messages was ...
IknowUshould2: Feasibility of a Youth-Driven Social Media Campaign to Promote STI and HIV Testing Among Adolescents in Philadelphia
Abstract A youth-driven, social media-based campaign aimed at improving knowledge about and increasing testing for sexually transmitted infections (STIs)/HIV among youth 13?17 years old was assessed by: tracking website/social media use throughout the campaign; online survey of knowledge of and attitudes towards STI testing 9 months after campaign launch; and comparing rates of STI testing at affiliated family planning clinics during the 1 year period immediately prior versus 1 year immediately after campaign launch. Over 1,500 youth were reached via social media. Survey results showed 46 % of youth had never been tested, but 70 % intended to test in the next 6 months. While the total number of GC/CT tests conducted and positive results were not significantly different p...
Protect (All) Your Boys from Early Trauma
It sounds like a conspiracy. The government is about to officially sanction intentional harming of infants. They want medical personnel to pressure parents to accept infant, child, even teen circumcision. Not only is the move based on faulty data and reasoning, it is unethical.read more (Source: Psychology Today Parenting Center)
Gambia: NBR RAC Observes World Aids Day On Importance of VCT
[The Point]Stakeholders from the HIV and AIDS sector in the North Bank Region, NBR, held a massive public awareness campaign to enhance community understanding on the importance of Voluntary Counseling and Testing, VCT, as a pre-requisite in the fight against HIV and AIDS. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: Understanding the Law Protecting Persons Living With HIV, Aids
[Guardian]IT is ignorance that fuels stigmatization of People Living With HIV, Aids (PLWHA), exposing them to ridicule, disgrace, verbal, physical and other forms of abuse in private and public settings. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Zimbabwe: NGO Worker and Nurse Fake HIV Results
[New Zimbabwe]A Health NGO worker employed by Global Fund and a nurse will know their fate this Tuesday after they allegedly faked results of an HIV test in favour of the nurse's husband. (Source: AllAfrica News: HIV-Aids and STDs)
The 'Berlin patient,' first and only person cured of HIV, speaks out
(Mary Ann Liebert, Inc./Genetic Engineering News) Timothy Ray Brown, long known only as the 'Berlin Patient' had HIV for 12 years before he became the first person in the world to be cured of the infection following a stem cell transplant in 2007. He recalls his many years of illness, a series of difficult decisions, and his long road to recovery in the first-person account, 'I Am the Berlin Patient: A Personal Reflection,' published in AIDS Research and Human Retroviruses. (Source: EurekAlert! - Medicine and Health)
Self?transfer and mortality amongst adults lost to follow?up in ART programmes in low? and middle?income countries: systematic review and meta?analysis
ConclusionsSubstantial unaccounted for transfers and deaths amongst patients LTFU confirms that retention and mortality is underestimated where the true outcomes of LTFU patients are not ascertained. (Source: Tropical Medicine and International Health)
Decision Aids and Shared Decision-Making in Neurocritical Care: An Unmet Need in Our NeuroICUs
Abstract Improved resuscitation methods and advances in critical care have significantly increased the survival of patients presenting with devastating brain injuries compared to prior decades. After the patient?s stabilization phase, families and patients are faced with ?goals-of-care? decisions about continuation of aggressive intensive care unit care or comfort care only (CMO). Highly varying rates of CMO between centers raise the question of ?self-fulfilling prophecies.? Disease severity, the physician?s communication and the family?s understanding of projected outcomes, their uncertainties, complication risks with continued care, physician bias, and the patient?s and surrogate?s wishes and values all influence a CMO decision. Disease-specific decision suppor...
Emergent burr-hole drainage of traumatic acute subdural haematoma with drain placement in pre-existing coagulopathy showing rapid neurological deterioration: A novel technique
Conclusion Emergency burr hole drainage should be considered in rapidly deteriorating patients with significant thicker ASDH with persistent thrombocytopenia and coagulopathy showing rapid neurological deterioration. (Source: The Indian Journal of Neurotrauma)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Scurvy in pediatric age group ? A disease often forgotten?
Publication date: Available online 5 January 2015 Source:Journal of Clinical Orthopaedics and Trauma Author(s): Anil Agarwal , Abbas Shaharyar , Anubrat Kumar , Mohd Shafi Bhat , Madhusudan Mishra Scurvy is caused by prolonged severe dietary deficiency of vitamin C. Being rare as compared to other nutritional deficiencies, it is seldom suspected and this frequently leads to delayed recognition of this disorder. Children with abnormal dietary habits, mental illness or physical disabilities are prone to develop this disease. The disease spectrum of scurvy is quite varied and includes dermatological, dental, bone and systemic manifestations. Subperiosteal hematoma, ring epiphysis, metaphyseal white line and rarefaction zone along with epiphyseal slips are common radiological findings. High ...
Delaying BCG Vaccination Until 8 Weeks of Age Results in Robust BCG-Specific T-Cell Responses in HIV-Exposed Infants
Conclusions.&nbsp;The immunogenicity of BCG vaccination in HIV-exposed, uninfected infants is not compromised when delayed until 8 weeks of age and results in robust BCG-specific T-cell responses at 14 weeks of age. These findings support further evaluation of this modified BCG vaccination strategy for HIV-exposed infants. Clinical Trials Registration.&nbsp;NCT02062580. (Source: The Journal of Infectious Diseases)
Advanced Immune Suppression is Associated With Increased Prevalence of Mixed-Strain Mycobacterium tuberculosis Infections Among Persons at High Risk for Drug-Resistant Tuberculosis in Botswana
We examined factors associated with mixed-strain Mycobacterium tuberculosis infections among patients at high risk for drug-resistant tuberculosis in Botswana. Thirty-seven (10.0%) of 370 patients with tuberculosis had mixed M. tuberculosis infections, based on 24-locus mycobacterial interspersed repetitive unit&ndash;variable number of tandem repeats genotyping. In log-binomial regression analysis, age &lt;37 years (adjusted prevalence ratio [PR], 1.92; 95% confidence interval [CI], 1.01&ndash;3.57) and prior tuberculosis treatment (adjusted PR, 2.31; 95% CI, 1.09&ndash;4.89) were associated with mixed M. tuberculosis infections. Among human immunodeficiency virus&ndash;infected patients, prior tuberculosis treatment (adjusted PR, 2.11; 95% CI, 1.04&ndash;4.31) and CD4+ T-cell count of &l...
Psychosocial Predictors and HIV-Related Behaviors of Old Adults Versus Late Middle-Aged and Younger Adults
Discussion: Old adults should be included in prevention efforts targeting knowledge, perceptions, and intentions toward condom use. Future studies should be cautious when overgeneralizing the results to all individuals aged 50 and older. (Source: Journal of Aging and Health)
Amphiphilic Cationic Nanogels as Brain-Targeted Carriers for Activated Nucleoside Reverse Transcriptase Inhibitors
Abstract Progress in AIDS treatment shifted emphasis towards limiting adverse effects of antiviral drugs while improving the treatment of hard-to-reach viral reservoirs. Many therapeutic nucleoside reverse transcriptase inhibitors (NRTI) have a limited access to the central nervous system (CNS). Increased NRTI levels induced various complications during the therapy, including neurotoxicity, due to the NRTI toxicity to mitochondria. Here, we describe an innovative design of biodegradable cationic cholesterol-?-polylysine nanogel carriers for delivery of triphosphorylated NRTIs that demonstrated high anti-HIV activity along with low neurotoxicity, warranting minimal side effects following systemic administration. Efficient CNS targeting was achieved by nanogel modification with bra...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Kenya: WHO's to Blame for Misuse of HIV Drugs in Kenya?
[Key Correspondents]Reports of Kenyan sex workers misusing HIV prevention drugs have left HIV activists wondering if the government invested enough in HIV prevention and education before purchasing medicine, worth four billion Kenyan shillings. (Source: AllAfrica News: HIV-Aids and STDs)
Global Health: African Nations Can Help More on AIDS, Study Says
The 12 African countries that receive most of the American taxpayer dollars spent fighting AIDS could do much more to pay their own way, according to a study published in The Lancet. (Source: NYT Health)
Pharmacogenomics and the Biology of Race
The numerous and impassioned responses to Nicholas Wade's recently published Troublesome Inheritance: Genes, Race and Human History have once again reminded us of the complexity, ambiguity and perils of writing about the biology of race. In the US one is reminded of the collective sins of our past, including the eugenics movement of the early twentieth century, whereby a disproportionate percentage of people of color and those from lower socio-economic classes were sterilized, and the Tuskegee Study conducted between 1932 and 1972 in which 600 African-American sharecroppers in rural Alabama were purposely not treated for syphilis in order to ascertain information on the long-term effects of the disease. More recently, debates about the biology of race have raged among certain academic circ...
Recommendations for HIV Prevention with Adults and Adolescents with HIV in the United States, 2014
Recommendations to advance the primary goals of the National HIV/AIDS Strategy for the United States: to prevent new HIV infections, increase the proportion of persons with HIV who are aware of their infection, prevent HIV-related illness and death, and reduce HIV-related health disparities. (Source: PHPartners.org)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Malawi: Global Fund Slaps CSOs in the Face Over Demos
[Malawi24]Global Fund has hinted that it is satisfied with explanations given by the National Aids Commission (NAC) and that the Beautify Malawi Trust (BEAM) should not refund the MK5 Million it allegedly got from the HIV/AIDS fighting body. (Source: AllAfrica News: Health and Medicine)
Current scenario of Opportunistic and co-infections in HIV-infected individuals at a tertiary care hospital in Mumbai, India
Conclusion: Nearly half of HIV-infected individuals were with OIs/CIs. Initiation of free ART programme since 2004 possibly associated with the type and rate of OIs/CIs. Tuberculosis and multiple OIs/CIs were associated with low CD4 counts. Infection was high in 31-40 years age group. Most of the spouses of individuals without OIs/CIs were HIV positive, indirectly indicates lack of condom use or lack of awareness of condom use. (Source: Indian Journal of Medical Microbiology)
A facile method for synthesizing water-soluble and superior sustained release anti-HIV prodrug SCs?d4T
In this study, a sulphonated chitosan?stavudine conjugate (SCs?d4T) was synthesized with a mild SO3·Py complex sulphonation strategy. Chemical characteristics and morphology of Cs?d4T and SCs?d4T were performed by NMR, XRD, FTIR, ICP-AES and SEM. SCs?d4T demonstrated satisfactory solubility (106-bold of Cs?d4T solubility), good anti-HIV activity (6-fold of d4T anti-HIV activity), and well sustained release ability. The major release product O-isopropyl-5?-H-phosphonate of d4T (d4T-P-H) showed higher anti-HIV activity than d4T. For further evaluating the influence of linker and sulphonation strategy on anti-HIV activity, chitosan grafted with d4T by succinyl linker (Cs?sd4T) and SCs?d4T sulphonated by oleum were also prepared. The result showed that the O-isopropyl monoph...
Dolutegravir for the Treatment of HIV-2 infection
Human immunodeficiency virus type 2 (HIV-2) was first isolated in 1986. Being originated in West Africa following inter-species transmission from natural wildlife monkey reservoirs, the virus currently infects 1?2 million humans worldwide. Former Portuguese colonies abroad such as Mozambique, Goa (India) and Brazil are amongst the regions with a larger number of HIV-2 cases outside West Africa [1]. Although HIV-2 infection typically evolves with a prolonged asymptomatic period, a significant proportion of patients may eventually develop AIDS, and therefore may benefit from earlier antiretroviral treatment [2]. (Source: Journal of Clinical Virology)
Monitoring the Hearing Handicap and the Recognition Threshold of Sentences of a Patient with Unilateral Auditory Neuropathy Spectrum Disorder with Use of a Hearing Aid
Conclusion?There was a reduction of the auditory handicap, although speech perception continued to be severely limited. There was a significant improvement of the recognition threshold of sentences in silence and in noise and of the signal-to-noise ratio after 3 months of HA use.[...]Thieme Publicações Ltda Rio de Janeiro, BrazilArticle in Thieme eJournals:Table of contents  |  Abstract  |  open access Full text (Source: International Archives of Otorhinolaryngology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Plaque burden in HIV-infected patients is associated with serum intestinal microbiota-generated trimethylamine.
CONCLUSION:: A link between TMA and atherosclerosis has not previously been established. The current study suggests that TMA may be a nontraditional risk factor related to the number of plaque segments and severity of calcified plaque burden in HIV. PMID: 25565500 [PubMed - as supplied by publisher] (Source: Atherosclerosis)
Relationship Agreements and Willingness to Participate in Couples HIV Testing and Counseling Among Heterosexuals in the U.S.
Authors: Jones JS, Stephenson R, Wall KM, Sullivan PS Abstract Couples HIV testing and counseling (CHTC) has been used for more than 20 years in African settings and more recently among men who have sex with men in the United States, but little is known about willingness of heterosexuals in the U.S. to use CHTC. We conducted an online survey of heterosexuals in sexual relationships to assess willingness to use CHTC and willingness to discuss relationship agreements within a couples counseling session. We found moderate levels of willingness to use CHTC and somewhat higher levels of willingness to discuss relationship agreements in a couples counseling session. The most frequently cited reason people were not willing was that they did not perceive themselves or their partners to be ...
Adapting and Implementing a Community Program to Improve Retention in Care among Patients with HIV in Southern Haiti: "Group of 6".
Conclusions. We report successful adaptation and implementation of a validated community HIV-care model in Southern Haiti. Group of 6 can reduce barriers to ART adherence, and will be integrated as a routine care option. PMID: 25548659 [PubMed] (Source: AIDS Research and Treatment)
Updates and trends in the treatment of major depressive disorder.
Authors: Papakostas GI, Ionescu DF Abstract Mental illness accounts for 7.4% of the total disease burden worldwide-more than HIV/AIDS, tuberculosis, or diabetes-making it the leading cause of years lost to disability. Depressive disorders make up 40.5% of that disability, the most of all mental illnesses. Despite the devastating global effects of depression, a report on approval trends by the US Food and Drug Administration (FDA) found that new molecular entities (NMEs) approved for targeting psychiatric illness peaked in the 1960s and have been declining since. PMID: 25551237 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Facing up to the ongoing challenge of Kaposi's sarcoma
Purpose of reviewKaposi's sarcoma is a mesenchymal tumour caused by infection with human herpesvirus 8, usually in the context of immunodeficiency. The global incidence of Kaposi's sarcoma rose dramatically with the outbreak of HIV and AIDS. Although the introduction of combined antiretroviral therapy (cART) has seen a dramatic decline in Kaposi's sarcoma incidence, it remains a significant burden of morbidity and mortality, especially in sub-Saharan Africa. This review considers the most recent evidence regarding the prevalence, current treatment strategies and future therapies for Kaposi's sarcoma. Recent findingsIn the post-cART era, the epidemiology of acquired immunodeficiency syndrome-related Karposi sarcoma (AIDS-KS) is changing, with a rising incidence in the context of immune reco...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Transmission of HIV drug resistance: lessons from sensitive screening assays
Purpose of reviewThe review discusses new technologies for the sensitive detection of HIV drug resistance, with a focus on applications in antiretroviral treatment (ART)-naïve populations. Recent findingsConventional sequencing is well established for detecting HIV drug resistance in routine care and guides optimal treatment selection in patients starting ART. Access to conventional sequencing is nearly universal in Western countries, but remains limited in Asia, Latin America, and Africa. Technological advances now allow detection of resistance with greatly improved sensitivity compared with conventional sequencing, variably increasing the yield of resistance testing in ART-naïve populations. There is strong cumulative evidence from retrospective studies that sensitive detection of resi...
Emerging concepts on the use of antiretroviral therapy in older adults living with HIV infection
Purpose of reviewWith the overwhelming success of combination antiretroviral therapy, HIV infection is now a chronic, but manageable, medical condition. Consequently, HIV-infected cohorts are ageing leading to new challenges in the life-long management of this condition. Here, we review recent data concerning the modern treatment of older HIV-infected adults. Recent findingsHIV-infected cohorts are ageing with the majority of those infected predicted to be more than 50 years old within the next 2 decades. There is emerging evidence of increased antiretroviral drug exposure in older individuals, but the evidence this leads to increased toxicity is less clear-cut. In addition, the choice of antiretroviral agents is more challenging in older HIV-infected patients because of the presence of co...
Challenges in managing HIV in people who use drugs
Purpose of reviewHIV management in people who use drugs (PWUD) is typically complex and challenging due to the presence of multiple medical and psychiatric comorbidities as well as social, physical, economic and legal factors that often disrupt the HIV continuum of care. In this review, we describe the individual, health systems and societal barriers to HIV treatment access and care retention for PWUD. In addition, the clinical management of HIV-infected PWUD is often complicated by the presence of multiple infectious and noninfectious comorbidities. Recent findingsImproved HIV treatment outcomes can be enhanced through improved testing and linkage strategies along with better treatment retention and antiretroviral (ART) adherence. Improved ART adherence can be achieved through the provisi...
Advancing the HIV cure agenda: the next 5 years
Purpose of reviewTo explore how ethical considerations, improved diagnostics and data from clinical trials might see the lowering of some of the barriers blocking a cure for HIV infection over the next 5 years. Recent findingsDespite the recent well publicized but eventually disappointing case reports, there remains only one successful HIV cure, the ?Berlin patient?. We will review the data suggesting that more potent agents might achieve in-vivo viral activation and explore the tantalizing phenomenon of ?posttreatment control? following treatment in primary HIV infection. We will also explore how new assays and novel interventions might move the field forward. SummaryThere is a need for new agents that can be safely tested to impact the viral reservoir, a more meaningful understan...
Methicillin-resistant Staphylococcus aureus Bone and Joint Infections in Children.
Authors: Pendleton A, Kocher MS Abstract Methicillin-resistant Staphylococcus aureus has been a clinically significant pathogen in orthopaedics for more than a decade. Research shows that these infections are more virulent and that treatment requires greater use of hospital resources. A multidisciplinary approach involving emergency department physicians, radiologists, interventional radiologists, MRI technicians, pediatricians, infectious disease specialists, anesthesiologists, and orthopaedic surgeons is necessary to optimize outcomes and minimize costs. Early use of MRI helps delineate the extent of infection, aids in the consideration of surgery, and provides valuable information for surgical planning. Healthcare providers need to stay vigilant during the course of the disease ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Correlates of psychological functioning of homeless youth in Accra, Ghana: a cross-sectional study
Conclusion: There is a need for holistic interventions to help improve the psychological and social functioning of homeless youth. Such programmes should strengthen socio-emotional coping strategies in street youth as well as address contextual risk factors such as stigma and discrimination by the public. (Source: International Journal of Mental Health Systems)
Explaining the effects of electronic cigarettes on craving for tobacco in recent quitters
Electronic cigarettes (e-cigarettes) are increasingly popular (Hajek et al., 2014). There is increasing evidence from randomized trials that e-cigarettes are effective smoking cessation aids (Adriaens et al., 2014; Hajek et al., 2014), and observational studies also suggest that e-cigarettes help smokers quit smoking and former smokers avoid relapse (Biener and Hargraves, 2014; Brown et al., 2014; Hajek et al., 2014). One possible cause of this effect is that e-cigarettes attenuate craving for tobacco and other tobacco withdrawal symptoms. (Source: Drug and Alcohol Dependence)
Experiences and expectations of participants completing an HIV cure focused clinical trial
No abstract available (Source: AIDS)
Minor viral population with drug-resistant mutation and risk of persistent low-level viremia or ?blips? in HIV-1 subtype C: Erratum
No abstract available (Source: AIDS)
Neighbourhood socio-economic position, late presentation and outcomes in people living with HIV in Switzerland
We examined the influence of neighbourhood SEP on presentation and outcomes in HIV-positive individuals in the era of combination antiretroviral therapy (cART). Methods:The neighbourhood SEP of patients followed in the Swiss HIV Cohort Study (SHCS) 2000?2013 was obtained on the basis of 2000 census data on the 50 nearest households (education and occupation of household head, rent, mean number of persons per room). We used Cox and logistic regression models to examine the probability of late presentation, virologic response to cART, loss to follow-up and death across quintiles of neighbourhood SEP. Results:A total of 4489 SHCS participants were included. Presentation with advanced disease [CD4+ cell count (Source: AIDS)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Show me your neighbours and I will tell you how you are
No abstract available (Source: AIDS)
High prevalence of measles seronegativity in adults with HIV infection born in the era of measles vaccination in Northern France
We investigated measles humoral immunity levels in a cohort of HIV-infected adult patients in France and attempted to identify risk factors for antimeasles antibodies seronegativity. Being born after 1983 [odds ratio (OR) 4.40; 95% confidence interval (95% CI) 1.26?14.09; P?=?0.0013] and a nadir CD4+ cell count below 100?cells/?l (OR 4.79; 95% CI 1.61?14.82; P?=?0.0048) were the two factors independently associated with measles seronegativity. Systematic measles antibody screening should be performed in HIV-infected individuals born in the era of measles vaccination (after 1983 in France). (Source: AIDS)
Teriparatide treatment of osteoporosis in an HIV-infected man: a case report and literature review
No abstract available (Source: AIDS)
Hepatitis B reverse seroconversion in a patient with well controlled HIV infection: a case report and a review of the literature
No abstract available (Source: AIDS)
Smoking and life expectancy among HIV-infected individuals on antiretroviral therapy in Europe and North America
Conclusion:Well treated HIV-infected individuals may lose more life years through smoking than through HIV. Excess mortality associated with smoking increases markedly with age. Therefore, increases in smoking-related mortality can be expected as the treated HIV-infected population ages. Interventions for smoking cessation should be prioritized. (Source: AIDS)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Trends in HIV acquisition, risk factors and prevention policies among youth in Uganda, 1999?2011
Conclusion:Dramatic decreases in HIV incidence occurred among adolescent women in Rakai. Changes in school enrolment and sexual experience were primarily responsible for declining HIV acquisition over time among adolescent women. Given limited improvement among young men and young adult women, the need for effective HIV prevention for young people remains critical. (Source: AIDS)
Dolutegravir efficacy at 48 weeks in key subgroups of treatment-naive HIV-infected individuals in three randomized trials
Conclusions:DTG is a once-daily, unboosted integrase inhibitor that is effective in combination with either ABC/3TC or TDF/FTC for first-line antiretroviral therapy in HIV-positive individuals with a variety of baseline characteristics. (Source: AIDS)
Effects of randomized rosuvastatin compared with placebo on bone and body composition among HIV-infected adults
Background:Statins have a beneficial effect on bone mineral density (BMD) and lean mass in some studies of HIV-uninfected adults; however, this has never been investigated in the setting of HIV infection. Design:HIV-infected individuals on stable antiretroviral therapy with a low-density lipoprotein cholesterol level of 130?mg/dl or less and evidence of heightened immune activation or inflammation were randomized to rosuvastatin 10?mg daily or placebo for 96 weeks. Methods:This was a prespecified interim analysis at 48 weeks. Between-group and within-group differences were compared; multivariable regression models were constructed. Results:Seventy-two individuals were randomized to statin therapy and 75 to placebo. Modest 48-week relative increases in trochanter BMD [0.9%; 95% confiden...
Efficacy and safety of lopinavir/ritonavir versus efavirenz-based antiretroviral therapy in HIV-infected pregnant Ugandan women
Objective:Combination antiretroviral therapy (ART) is now the global standard for HIV-infected pregnant and breastfeeding women at all CD4+ cell counts. We compared the efficacy and safety of an efavirenz versus lopinavir/ritonavir regimen for HIV-infected pregnant women initiating ART in rural Uganda. Design:Randomized clinical trial. Methods:We performed a planned secondary analysis comparing viral load suppression (HIV-1 RNA ?400?copies/ml), safety, and HIV transmission to infants in a trial designed to test the hypothesis that lopinavir/ritonavir versus efavirenz-based ART would reduce placental malaria (PROMOTE, ClinicalTrials.gov, NCT00993031). HIV-infected, ART-naive pregnant women at 12?28 weeks gestation and any CD4+ cell count were randomized. ART was provided and participa...
Impact of body weight on virological and immunological responses to efavirenz-containing regimens in HIV-infected, treatment-naive adults
Conclusion:Virological and immunological responses to initial EFV-containing regimens were not impaired in heavy individuals, suggesting that the standard 600?mg EFV dosage is appropriate across a wide weight range. (Source: AIDS)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Opportunities for improving the efficiency of paediatric HIV treatment programmes
Conclusion:Clinically driven monitoring of ART is cost-effective in most circumstances. Routine laboratory monitoring is generally not cost-effective at current prices, except possibly CD4+ testing amongst adolescents initiating ART. Committing resources to ensure continued provision of cotrimoxazole in health facilities is more likely to represent an efficient use of resources. (Source: AIDS)
The role of HIV-specific antibody-dependent cellular cytotoxicity in HIV prevention and the influence of the HIV-1 Vpu protein
There is growing interest in the role of anti-HIV antibody-dependent cellular cytotoxicity (ADCC) antibodies in the prevention and control of HIV infection. Passive transfer studies in macaques support a role for the Fc region of antibodies in assisting in the prevention of simian-human immunodeficiency virus (SHIV) infection. The Thai RV144 HIV-1 vaccine trial induced anti-HIV ADCC antibodies that may have played a role in the partial protection observed. Several observational studies support a role for ADCC antibodies in slowing HIV disease progression. However, HIV evolves to escape ADCC antibodies and chronic HIV infections causes dysfunction of effector cells such as natural killer (NK) cells that mediate the ADCC functions. Further, four recent studies show that the HIV-1 Vpu protein...
Cytomegalovirus, and possibly Epstein?Barr virus, shedding in breast milk is associated with HIV-1 transmission by breastfeeding
Objective:Postnatal HIV-1 mother-to-child transmission (MTCT) occurs in spite of antiretroviral therapy. Co-infections in breast milk with cytomegalovirus (CMV) and Epstein?Barr virus (EBV) are associated with increased HIV-1 shedding in this compartment. We investigated CMV levels and EBV detection in breast milk as potential risk factors for MTCT of HIV-1 via breastfeeding. Methods:Cell-free HIV-1 RNA, cell-associated HIV-1 DNA, CMV and EBV DNA were quantified in breast milk from 62 HIV-infected mothers and proven postnatal MTCT of HIV-1 via breastfeeding. Controls were 62 HIV-positive mothers with HIV-uninfected infants. Results:Median (interquartile range) CMV DNA viral load was significantly higher in cases [88?044 (18?586?233?904)] than in controls [11?167 (3221?31?15...
The impact of HIV exposure and maternal Mycobacterium tuberculosis infection on infant immune responses to bacille Calmette-Guérin vaccination
Conclusion:Effects of maternal HIV and Mtb infection on infant immune profiles at birth are transient only, and HIV-exposed, noninfected infants have the same potential to respond to and be protected by BCG vaccination as HIV-unexposed infants. (Source: AIDS)
Nigeria: HIV/Aids in Nigeria - How Far, So Far?
[Independent (Lagos)]Abuja -Recently, stakeholders in the fight against HIV/AIDS from the 36 states of the federation and the Federal Capital Territory (FCT) including partners such United Nations Children Fund (UNICEF) and World Health Organisation (WHO) under the leadership of the HIV Division of the Federal Ministry of Health converged in Abuja to review activities being implemented in the fight against the scourge in Nigeria. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Updated Fact Sheets Available From CDC
The Centers for Disease Control and Prevention (CDC) recently updated the following four fact sheets: &nbsp; HIV Among African Americans HIV Among African American Gay and Bisexual Men HIV Among Gay and Bisexual Men HIV Among Latinos The fact sheets include information and statistics on diagnoses of HIV infection and AIDS in each population. Prevention challenges and information about CDC programs and campaigns are also included. (Source: AIDSinfo At-a-Glance: Offering Information on HIV/AIDS Treatment, Prevention, and Research, A Service of the U.S. Department of Health and Human Services (DHHS))
Premarital sexual activity among unmarried adolescents in northern Ethiopia: a cross-sectional study
Conclusions The study of this finding clearly demonstrated that rural adolescents initiate sexual activity early with limited protection from infections and unintended pregnancies. Community and school based sexual health education is recommended. (Source: Sexual and Reproductive Healthcare)
Alcohol consumption and reproductive health risks in rural Central Kenya
Conclusions Results indicate a need to address alcoholism in rural Kenya as a public health problem focusing on education and understanding of the long-term health consequences. Addressing the impact on male reproductive health is crucial because it impacts the wider community. Given the complex relationship between alcohol abuse and HIV/AIDS, it is also important for prevention interventions to target married women and non-alcohol consumers. Furthermore, engaging communities will ensure development of culture- and gender-specific interventions. Such engagement requires facilitation of health practitioners for development of meaningful community-based initiatives. (Source: Sexual and Reproductive Healthcare)
In vitro photodynamic inactivation of by phenothiazine dye (New methylene blue) and Indocyanine green (EmunDo)
Oral candidiasis is the most common opportunistic infection that influences the oral mucosa. The most predominant etiological agent in oral candidiasis is C. Albicans, which corresponds to 70-80% of all microorganisms isolated from oral lesions[1,2]. Oral candidiasis is a common manifestation of fungal infections, especially in immuno-compromised patients, such as HIV/AIDS patients and cancer patients receiving radiotherapy and chemotherapy [3]. This microorganism does not cause systemic or local problems in healthy patients. (Source: Photodiagnosis and Photodynamic Therapy)
HIV-associated osteoporosis
AIDS is a disease, caused by the HIV belonging to the retroviral family, transmitted through blood, body fluids and unprotected sexual contact that may involve a number of complications of immune, cardiovascular and pulmonary systems. Antiretroviral drugs are usually used in treatment. Mild bone loss occurs with the start of antiretroviral treatment. Bone mass seems to be constant and improved in prolonged use of antiretrovirals. Oral and parenteral bisphosphonates are useful in patients, and they are referred to first-line treatment to prevent frailty and bone rupture. (Source: Reviews in Medical Microbiology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Bilateral Cochlear Implantation for Hearing-Impaired Children: Criterion of Candidacy Derived from an Observational Study
Conclusions:Children with an unaided four-frequency PTA of 80 dB HL or poorer in both ears should be considered candidates for bilateral cochlear implantation. In cases where a four-frequency PTA cannot be measured, the criterion of candidacy should be a two-frequency PTA of 85 dB HL or poorer in both ears. If adopted by policy-makers, these recommendations would expand the provision of cochlear implants among children in England and Wales. (Source: Ear and Hearing)
Estimating Productivity Costs in Health Economic Evaluations: A Review of Instruments and Psychometric Evidence
Abstract Health economic evaluations (i.e. cost-effectiveness appraisal of an intervention) are useful aids for decision makers responsible for the allocation of scarce healthcare resources. The relevance of including health-related productivity costs (or benefits) in these evaluations is increasingly recognized and, as such, reliable and valid instruments to quantify productivity costs are needed. Over the years, a number of work productivity instruments have emerged in the literature, along with a growing body of psychometric evidence. The overall aim of this paper is to provide a review of available instruments with potential for estimating health-related productivity costs. This included the Health and Labor Questionnaire, Health and Work Performance Questionnaire, Health-Rel...
HIV Counseling and Testing for the Prevention of Mother-to-Child Transmission of HIV in Swaziland: A Multilevel Analysis
Abstract HIV counseling and voluntary testing during antenatal care have been proven to reduce the risk of HIV transmission from mother to child, through increasing knowledge about safe behaviors, ascertaining HIV status and increasing coverage of effective antiretroviral regimens. However, it remains that, in developing countries where 95 % of mother-to-child HIV transmissions (MTCT) take place, such interventions are not widely accessible or available. Using a nationally representative cross-sectional household survey, the present study aimed to examine individual- and contextual-level influences on the receipt of HIV pre-test counseling and uptake of HIV testing during the antenatal care period in Swaziland, a country highly burdened by HIV/AIDS. The study sample was restrict...
Incorrect Grant Information
This article was corrected online and in print. (Source: JAMA Pediatrics)
Capsule Commentary on Tomko et al., A Comparison of Web- Versus Print-Based Decision Aids for Prostate Cancer Screening: Participants? Evaluation and Utilization
(Source: Journal of General Internal Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Fidelity of Implementation of an Evidence-Based HIV Prevention Program among Bahamian Sixth Grade Students
This study explores fidelity of implementation of the intervention, factors that may influence implementation fidelity, and the impact of variations in the implementation fidelity on student outcomes. Data were collected in the first wave of national implementation in 2011, involving 35 government primary schools and 110 teachers and 2,811 students. Structural equation modeling was performed to examine the relationships among factors which facilitated or impeded teachers? implementation of FOYC. Results indicate that teachers taught 16.3 out of 30 core activities, 24.9 out of 46 total activities, and 4.4 out of 8 sessions on average. The strongest predictor of implementation fidelity was teacher comfort level with the FOYC curriculum. Teachers who did not perceive the FOYC intervention t...
Effects of environmental disturbance on phenotypic variation: an integrated assessment of canalization, developmental stability, modularity, and allometry in lizard head shape.
Authors: Lazi? MM, Carretero MA, Crnobrnja-Isailovi? J, Kaliontzopoulou A Abstract Abstract When populations experience suboptimal conditions, the mechanisms involved in the regulation of phenotypic variation can be challenged, resulting in increased phenotypic variance. This kind of disturbance can be diagnosed by using morphometric tools to study morphological patterns at different hierarchical levels and evaluate canalization, developmental stability, integration, modularity, and allometry. We assess the effect of urbanization on phenotypic variation in the common wall lizard (Podarcis muralis) by using geometric morphometrics to assess disturbance to head shape development. The head shapes of urban lizards were more variable and less symmetric, suggesting that urban living is...
CD4+ T cell counts reflect the immunosuppressive state of CD4 helper cells in patients after allogeneic stem cell transplantation
Abstract The recovery of the host immune system after allogeneic hematopoietic stem cell transplantation is pivotal to prevent infections, relapse, and secondary malignancies. In particular, numerical CD4+ T cells reconstitution is delayed and CD4 helper cell function is considered impaired as a consequence of the transplant procedure and concomitant immunosuppressive medication. From HIV/AIDS patients, it is known that numerical and functional CD4 defects increase the risk of opportunistic infections. However, and in contrast to patients with HIV, anti-infective prophylaxis after allogeneic transplantation is usually given for 6 months depending on immunosuppressive medication and existing graft-versus-host disease but independently of absolute CD4+ T cells counts. We hypothesi...
Three-dimensional echocardiographic assessment of atrial septal defects.
Authors: German C, Nanda NC Abstract Echocardiography provides a useful tool in the diagnosis of many congenital heart diseases, including atrial septal defects, and aids in further delineating treatment options. Although two-dimensional echocardiography has been the standard of care in this regard, technological advancements have made three-dimensional echocardiography possible, and the images obtained in this new imaging modality are able to accurately portray the morphology, location, dimensions, and dynamic changes of defects and many other heart structures during the cardiac cycle. PMID: 25566714 [PubMed - in process] (Source: Annals of Cardiac Anaesthesia)
Encephalitis of Unclear Origin Diagnosed by Brain Biopsy A Diagnostic Challenge
Conclusions and RelevanceENOS is the most common initial type of encephalitis diagnosed by brain biopsy. In such patients, it may be worth having the biopsy materials reviewed again in a comprehensive fashion by a neuropathologist because additional review led to a more specific categorization in one-third of our cases. Ancillary testing, clinical correlation, and clinical follow-up establish more specific diagnoses in some patients. ENOS still remains a diagnostic challenge after all these efforts in many cases. Current algorithms are of limited value. More advanced methods and better diagnostic algorithms are needed to characterize these patients. (Source: JAMA Neurology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Novel mechanisms of controlling the activities of the transcription factors Spo0A and ComA by the plasmid?encoded quorum sensing regulators Rap60?Phr60 in Bacillus subtilis
Summary Bacillus subtilis and its closest relatives have multiple rap?phr quorum sensing gene pairs that coordinate a variety of physiological processes with population density. Extra?chromosomal rap?phr genes are also present on mobile genetic elements, yet relatively little is known about their function. In this work, we demonstrate that Rap60?Phr60 from plasmid pTA1060 coordinates a variety of biological processes with population density including sporulation, cannibalism, biofilm formation, and genetic competence. Similar to other Rap proteins that control sporulation, Rap60 modulates phosphorylation of the transcription factor Spo0A by acting as a phosphatase of Spo0F?P, an intermediate of the sporulation phosphorelay system. Additionally, Rap60 plays a noncanonical role in ...
Oral disease and HIV/AIDS
Since the first days of the HIV disease epidemic, remarkable discoveries have been made related to variations in the oral health of persons living with this disease or AIDS. Oral candidiasis (OC) was identified as a comorbid condition and early sign of immune suppression. Oral Kaposi sarcoma (KS) was recognized as a sign of AIDS related to oral disease. AIDS-associated oral hairy leukoplakia (OHL) and OC are now considered sentinels for decreased immune competence and clinical indicators of an increased possibility that HIV infection is present. (Source: Dental Abstracts)
Pertrochanteric Hip Fracture: A "Routine" Fracture With a Potentially Devastating Vascular Complication.
Pertrochanteric Hip Fracture: A "Routine" Fracture With a Potentially Devastating Vascular Complication. Orthopedics. 2015 Jan 1;38(1):e75-e79 Authors: Sullivan MP, Schenker ML, Mehta S Abstract Vascular injuries in conjunction with low-energy geriatric hip fractures, although uncommon, can be life-threatening. Furthermore, vascular injuries are usually iatrogenic, related to malpositioning of percutaneous reduction aids, aberrant drilling, or poorly sized implants. The authors describe an older woman who had a low-energy pertrochanteric hip fracture. She was noted preoperatively to have an isolated decrease in hemoglobin of 4.7 g/dL in the 2.5 days before surgery. Fracture reduction was performed with closed and percutaneous techniques with the limb free-legged on a r...
Persistence and pathogenesis of the neurotropic polyomavirus JC
This article is protected by copyright. All rights reserved. (Source: Annals of Neurology)
HIV Hearing Losses Cross High and Low FrequenciesHIV Hearing Losses Cross High and Low Frequencies
HIV-positive men and women are more likely to experience low-frequency and high-frequency hearing loss than their HIV-negative counterparts, researchers say. Reuters Health Information (Source: Medscape Medical News Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Tanzania: Scribes Need More Training On HIV-Aids
[Daily News]Veteran journalist Salim Said Salim (standing) addresses fellow scribes at a training workshop on HIV/AIDS in Zanzibar recently. (File photo) (Source: AllAfrica News: HIV-Aids and STDs)
Socrates Was Not a Pimp: Changing the Paradigm of Questioning in Medical Education
The slang term ?pimping? is widely recognized by learners and educators in the clinical learning environment as the act of more senior members of the medical team publicly asking questions of more junior members. Although questioning as a pedagogical practice has many benefits, pimping, as described in the literature, evokes negative emotions in learners and leads to an environment that is not conducive to adult learning. Medical educators may employ pimping as a pedagogic technique because of beliefs that it is a Socratic teaching method. Although problems with pimping have previously been identified, no alternative techniques for questioning in the clinical environment were suggested. The authors posit that using the term ?pimping? to describe questioning in medical education is ...
Malawi: Controversy Over NAC Money As Mulhako Denies Receiving Funds
[Malawi24]Mist still surrounds the National Aids Commission (Nac) in which the board 'donated' money to some organisations which do not initially work towards combating HIV/AIDS. (Source: AllAfrica News: Health and Medicine)
Wayne Koff
Nature Reviews Drug Discovery 14, 10 (2015). doi:10.1038/nrd4528 The success rate for vaccines is even lower than for biopharmaceutical drugs, by some accounts. In an attempt to turn things around and address long-standing vaccinology problems, Wayne Koff, Chief Scientific Officer at the International AIDS Vaccine Initiative (IAVI), and colleagues proposed a Human Vaccines Project in 2013. Top vaccinologists met to outline a scientific approach and business strategy in 2014, and the Human Vaccines Project could now launch by this summer, Koff tells Asher Mullard. (Source: Nature Reviews Drug Discovery)
Effectiveness of enfuvirtide in a cohort of highly antiretroviral-experienced HIV-1-infected patients in Mexico
Background: Treatments in patients with multidrug resistance often involve the use of multiple agents with partial antiviral activity and overlapping metabolic toxicities. Enfuvirtide is therefore a welcome addition to the antiretroviral management of patients with multiclass resistant virus, given the low risk of systemic toxicities and novel mechanism of action relative to existing drug classes.The aim of this study was to evaluate the effectiveness of ENF plus optimized background regimen (OBR) in a Mexican cohort of highly HIV-1 ARV-experienced patients. Methods: Prospective cohort of treatment-experienced HIV-1-infected adults with virological failure who started therapy with an ENF-containing regimen. The effectiveness of ENF treatment was evaluated with percentages of undetectable H...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Stigma in HIV-infected healthcare workers in Kenya: A mixed method approach
HIV-related stigma decreases access to HIV testing, prevention, and treatment services. Our mixed method study explored stigma as perceived, experienced, and managed in a sample of 76 HIV-infected health care workers in Kisumu, Kenya. Stigma was quantitatively measured using the HIV/AIDS Stigma Instrument for People Living with AIDS (HASI-P). Overall, subjects experienced low stigma levels (Mean = 7.88, SD = 12.90; Range = 0-61), and none of the sociodemographic variables were predictive of stigma. (Source: Journal of the Association of Nurses in AIDS Care)
Minimum standards for the certification of patient decision support interventions: feasibility and application
Shared decision-making and the use of patient decision support interventions (also called patient decision aids) have been important innovations in healthcare [1,2], and have recently become part of health policy developments worldwide [3?5]. In the UK, the 2010 White Paper: ?Liberating the NHS? [3] and the NHS operating framework [6] promote the development and implementation of patient decision support interventions to support shared decision-making. These interventions are designed to help patients make informed decisions about their health care [8?10]. (Source: Patient Education and Counseling)
Year in Review: HIV-AIDS
(MedPage Today) -- Tragedy in the skies overshadowed AIDS conference. (Source: MedPage Today Infectious Disease)
'Very Strong Evidence' Of HIV Transmission During Porn Shoot
LOS ANGELES (AP) ? California public health officials have issued an alert after finding "very strong evidence" that an adult film actor became infected with HIV as a result of unprotected sex on an out-of-state film shoot. The Department of Public Health said Monday that the male actor tested positive for the virus that causes AIDS after engaging in unprotected sex with several other male actors during two separate film shoots. He had tested negative before the shoot. "During the second film shoot, he had symptoms of a viral infection," the alert states. "The actor went to a clinic and had another blood test that showed he had recently become infected with HIV." One actor from the second shoot has since tested positive for HIV. According to the health department, lab results indicate ...
Prograf Aids in Myopathy-Related Lung Disease
(MedPage Today) -- Study "provides some reassurance" on use of tacrolimus. (Source: MedPage Today Primary Care)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Keeping HIV and AIDS in check - Deutsche Welle video
Keeping HIV and AIDS in check: Dr. Keikawus Arastéh is an internist at the Center for Infectious Medicine and HIV of the Berlin-based Auguste-Viktoria-Klinikum. He explains how to recognize an HIV infection, how to avoid contracting it in the first place, and what therapies help keep it in check. Posted at Clinical Cases and Images. Stay updated and subscribe, follow us on Twitter and connect on Facebook. (Source: Clinical Cases and Images)
This Muscle Could Save Your Life
You probably know someone who?s fallen and broken a hip. But what you may not know is that it?s not just elders who fall. The risk for breaking a hip doubles every five years after you turn fifty. And 30% of people who fall and break a hip develop complications and die within a year.1 The good news is you can use the power of your muscles to avoid falling and breaking your hip, starting today. The fact is falling down doesn?t have to be a part of aging. You just have to decide that you?re not going to take it lying down. It involves strengthening your quadriceps muscles. You see, the signals to your muscles start to slow down as you get older, making it harder for your muscles to respond. Researchers looked at how muscles respond when the brain cells that activate them ? called n...
Southern Africa: SMS for Healthy, Aids-Free Babies
[IPS]United Nations -In rural Zambia and Malawi, new mums face long delays finding out if they have passed HIV on to their babies. (Source: AllAfrica News: Health and Medicine)
Spontaneous Regression of Non?Small-Cell Lung Cancer in AIDS After Immune Reconstitution
No abstract available (Source: Journal of Thoracic Oncology)
NEJM Journal Watch HIV/AIDS Top Stories of 2014 (FREE)
By the NEJM Journal Watch Editors The top stories in HIV and AIDS this year ? (Source: Physician's First Watch current issue)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Nostalgia buffers the negative impact of low procedural justice on cooperation
Publication date: March 2015 Source:Organizational Behavior and Human Decision Processes, Volume 127 Author(s): Marius van Dijke , Tim Wildschut , Joost M. Leunissen , Constantine Sedikides This research integrates the discrete emotion of nostalgia (a sentimental longing for the past) with relational models of procedural justice. An organizational survey and four experiments demonstrated that nostalgia buffers (i.e., weakens) the deleterious impact of low (compared to high) procedural justice on organizational citizenship behavior (OCB) and cooperation with authorities. Low procedural justice undermined social connectedness with authorities, and nostalgia?s buffering role derived from its capacity to block the pathway from this reduced social connectedness to decreased OCB and cooperat...
Cytomegalovirus Coinfection Is Associated With an Increased Risk of Severe Non-AIDS-Defining Events in a Large Cohort of HIV-Infected Patients
Conclusions In our study population, CMV/HIV coinfection was associated with the risk of severe non&ndash;AIDS-defining events/non&ndash;AIDS-related death, especially with cardiovascular and cerebrovascular events, independently of other prognostic factors. This finding supports a potential independent role of CMV coinfection in vascular/degenerative organ disorders in HIV-infected subjects. (Source: The Journal of Infectious Diseases)
Cytomegalovirus Upregulates Expression of CCR5 in Central Memory Cord Blood Mononuclear Cells, Which May Facilitate In Utero HIV Type 1 Transmission
Administration of combination antiretroviral therapy to human immunodeficiency virus type 1 (HIV-1)&ndash;infected pregnant women significantly reduces vertical transmission. In contrast, maternal co-opportunistic infection with primary or reactivated cytomegalovirus (CMV) or other pathogens may facilitate in utero transmission of HIV-1 by activation of cord blood mononuclear cells (CBMCs). Here we examine the targets and mechanisms that affect fetal susceptibility to HIV-1 in utero. Using flow cytometry, we demonstrate that the fraction of CD4+CD45RO+ and CD4+CCR5+ CBMCs is minimal, which may account for the low level of in utero HIV-1 transmission. Unstimulated CD4+ CBMCs that lack CCR5/CD45RO showed reduced levels of HIV-1 infection. However, upon in vitro stimulation with CMV, CBMCs un...
Pharmacokinetics of Efavirenz and Treatment of HIV-1 Among Pregnant Women With and Without Tuberculosis Coinfection
Conclusions Pregnancy increased the risk of low efavirenz concentrations, but MTCT was rare. A detectable HIV-viral load at delivery was more common among pregnant women with tuberculosis, in whom ART was generally initiated later. (Source: The Journal of Infectious Diseases)
Predictors of Women?s Intentions to be Screened for HIV during Pregnancy
Detection of HIV during pregnancy and a consequent treatment may reduce harm to the fetus. We examine whether the combination of Health Belief Model and Theory of Planned Behavior predicts women?s intentions to be screened for HIV during pregnancy. Two hundred Israeli women who participated in birth preparation classes completed e-mailed questionnaires. The results of a multiple linear regression reveal that perceived susceptibility to HIV, perceived benefits of screening, perceived severity of the illness, health motivation, and normative beliefs predicted women's intentions to be screened, while normative beliefs (beliefs about the extent to which significant others think they should be screened for HIV during pregnancy) was the most significant factor. (Source: Journal of the Associat...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Mortality among older adults with opioid use disorders in the Veteran's Health Administration, 2000-2011
Opioid use disorders (OUD) are associated with significant mortality. Regular and dependent opioid users die at nearly 15 times the rate of their age- and sex-matched peers, with a crude mortality rate of 2% per year (Degenhardt et al., 2011). Common causes of death include drug overdose, suicide, trauma, and AIDS-related illnesses. The relative contribution of specific causes of death to overall mortality varies with factors such as geography, background HIV prevalence and access to opioid substitution treatment (Degenhardt et al., 2011). (Source: Drug and Alcohol Dependence)
Mortality among older adults with opioid use disorders in the Veteran's Health Administration, 2000?2011
Opioid use disorders (OUD) are associated with significant mortality. Regular and dependent opioid users die at nearly 15 times the rate of their age- and sex-matched peers, with a crude mortality rate of 2% per year (Degenhardt et al., 2011). Common causes of death include drug overdose, suicide, trauma, and AIDS-related illnesses. The relative contribution of specific causes of death to overall mortality varies with factors such as geography, background HIV prevalence and access to opioid substitution treatment (Degenhardt et al., 2011). (Source: Drug and Alcohol Dependence)
Validation of a Novel Combination Hearing Aid and Tinnitus Therapy Device
Conclusions: Results of this study suggest that the use of hearing aids alone or hearing aids plus the use of sound generators both provide significant benefit with respect to alleviating effects of tinnitus. A larger controlled clinical trial is needed to obtain more definitive results regarding the two configurations of hearing aids. (Source: Ear and Hearing)
Bilateral Cochlear Implantation for Hearing-Impaired Children: Criterion of Candidacy Derived from an Observational Study
Conclusions: Children with an unaided four-frequency PTA of 80 dB HL or poorer in both ears should be considered candidates for bilateral cochlear implantation. In cases where a four-frequency PTA cannot be measured, the criterion of candidacy should be a two-frequency PTA of 85 dB HL or poorer in both ears. If adopted by policy-makers, these recommendations would expand the provision of cochlear implants among children in England and Wales. (Source: Ear and Hearing)
Reduced Darunavir Dose Maintains HIV SuppressionReduced Darunavir Dose Maintains HIV Suppression
A 600-mg dose of darunavir is as effective as the approved 800-mg dose in maintaining HIV suppression, researchers from Spain report. Reuters Health Information (Source: Medscape Medical News Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Nigeria: The Cure
[This Day]Kayode Oguntebi writes like Grisham. His approach is not tentative. He sees the pictures and puts them on paper. His sense of pacing ensures that the reader is not lost in the wilderness of boredom. His direct style makes Viral Load an interesting tale - one that chronicles the tragedies of this world on the parchment of hope. (Source: AllAfrica News: HIV-Aids and STDs)
Perception of HIV Risk and Adherence to FEM-PrEPPerception of HIV Risk and Adherence to FEM-PrEP
Does perceived HIV risk influence patients' decisions to adhere to pre-exposure prophylaxis? JAIDS: Journal of Acquired Immune Deficiency Syndromes (Source: Medscape Today Headlines)
Nigeria: 3,051 Die of Aids in Nigeria in 4 Years
[Daily Trust]Nigeria has recorded a total of 3,051 deaths out of 187,846 AIDS cases within a span of four years, the National Bureau of Statistics (NBS) has reported. (Source: AllAfrica News: HIV-Aids and STDs)
Zimbabwe: 1,3 Million Zimbabweans Living With HIV/Aids
[Financial Gazette]AT LEAST 1,3 million people in Zimbabwe are living with HIV/AIDS compared to two million recorded in the previous years, a government official has said. (Source: AllAfrica News: HIV-Aids and STDs)
Survival, Continence and Potency (SCP) recovery after radical retropubic prostatectomy: A long-term combined evaluation of surgical outcomes
Conclusion Survival, Continence and Potency (SCP) classification offer a comprehensive report of surgical results, even in those patients who do not represent the best category, thus allowing to provide a much more accurate evaluation of outcomes after RP. (Source: European Journal of Surgical Oncology (EJSO))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Natural Killer Cells: In Health and Disease
Publication date: Available online 27 December 2014 Source:Hematology/Oncology and Stem Cell Therapy Author(s): Arundhati Mandal , Chandra Viswanathan Natural killer (NK) cells constitute our bodies? frontline defense system, guarding against tumors and launching attacks against infections. The activities of NK cells are regulated by the interaction of various receptors expressed on their surfaces with cell surface ligands. While the role of NK cells in controlling tumor activity is relatively clear, the fact that they are also linked to various other disease conditions is now being highlighted. Here, we present an overview of the role of NK cells during normal body state as well as under diseased state. We discuss the possible utilization of these powerful cells as immunotherapeutic a...
Live course: pediatric HIV [FOR YOUR INFORMATION]
(Source: AAP News)
Preparatory behaviours and condom use during receptive and insertive anal sex among male-to-female transgenders (Waria) in Jakarta, Indonesia.
CONCLUSIONS: Our results have implications for the development of interventions to target preparatory behaviours and condom use behaviours. Five behaviours and three psychological factors as defined in the TPB are to be targeted. PMID: 25529498 [PubMed - in process] (Source: Journal of the International AIDS Society)
AIDS, People who Use Drugs, and Altruism: Reflection on a Personal Image
Substance Use & Misuse, Ahead of Print. (Source: Substance Use and Misuse)
Hearing preservation and cochlear implants according to inner ear approach: multicentric evaluation
Conclusion The hearing preservation occurred in 89.4% of cases. There was no significant difference between the forms of inner ear approach. (Source: Brazilian Journal of Otorhinolaryngology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Pain, Anxiety, and Negative Outcome Expectations for Activity: Do Negative Psychological Profiles Differ Between the Inactive and Active?
ConclusionIdentifying differences in negative psychological factors aids in the understanding of differential adherence between activity groups and highlights possible factors to change in future intervention and research. (Source: Arthritis Care and Research)
HIV Tied to Worse Hearing in Older Adults
Study suggests virus might have effect on the inner ear, one expert said Source: HealthDay Related MedlinePlus Pages: HIV/AIDS, Hearing Disorders and Deafness (Source: MedlinePlus Health News)
Hepatitis C Infection Isn't Related to HIV Brain Woes
Mood swings, memory problems may be triggered by inflammation, researchers say Source: HealthDay Related MedlinePlus Pages: HIV/AIDS and Infections, Hepatitis C, Living with HIV/AIDS (Source: MedlinePlus Health News)
Oral manifestations in AIDS
Publication date: Available online 25 December 2014 Source:Brazilian Journal of Otorhinolaryngology Author(s): Cleonice Hitomi Watashi Hirata (Source: Brazilian Journal of Otorhinolaryngology)
ISPyB for BioSAXS, the gateway to user autonomy in solution scattering experiments
Logging experiments with the laboratory-information management system ISPyB (Information System for Protein crystallography Beamlines) enhances the automation of small-angle X-ray scattering of biological macromolecules in solution (BioSAXS) experiments. The ISPyB interface provides immediate user-oriented online feedback and enables data cross-checking and downstream analysis. To optimize data quality and completeness, ISPyBB (ISPyB for BioSAXS) makes it simple for users to compare the results from new measurements with previous acquisitions from the same day or earlier experiments in order to maximize the ability to collect all data required in a single synchrotron visit. The graphical user interface (GUI) of ISPyBB has been designed to guide users in the preparation of an experiment. Th...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Linkage to and engagement in HIV care in western Kenya: an observational study using population-based estimates from home-based counselling and testing
Publication date: January 2015 Source:The Lancet HIV, Volume 2, Issue 1 Author(s): Becky L Genberg , Violet Naanyu , Juddy Wachira , Joseph W Hogan , Edwin Sang , Monicah Nyambura , Michael Odawa , Corey Duefield , Samson Ndege , Paula Braitstein Background Few population-based studies exist on the HIV care continuum in sub-Saharan Africa. We aimed to describe engagement in care in all adults with an existing diagnosis of HIV and to assess the time to and predictors of linkage and engagement in adults newly diagnosed via home-based counselling and testing (HBCT) in a high-prevalence setting in western Kenya. Methods Data were derived from AMPATH (Academic Model Providing Access to Healthcare), which has provided HIV care in western Kenya since 2001 and the HBCT programme, which has been...
FDA to Lift Ban on Blood Donations by Gay Men
Agency cites data from other countries showing such donations wouldn't compromise blood supply (Source: Fertility News - Doctors Lounge)
Fine-Needle Aspiration Cytology of Disseminated Kaposi Sarcoma of the Bone in an AIDS Patient
We present a case of disseminated KS of the axial skeleton in a 45-year-old African-American man with AIDS which was diagnosed on FNA cytologic examination. The patient presented with multiple lytic lesions in the axial skeleton. The aspirate, core-needle biopsy and touch imprint cytology of a bone lesion demonstrated clusters of spindle and epithelioid cells in radial and streaming arrangement with indistinct intercytoplasmic borders, elongated nuclei, fine chromatin and inconspicuous nucleoli. Immunohistochemical studies revealed positivity for HHV-8 and vascular markers. The cytomorphologic and ancillary features of the case are presented and discussed.Acta Cytologica (Source: Acta Cytologica)
South Africa: Tender to Supply ARVs Awarded to Companies
[SAnews.gov.za]The national Department of Health has announced various pharmaceutical companies that won the three year tender to supply antiretroviral (ARVs) to millions of patients on treatment in South Africa. (Source: AllAfrica News: HIV-Aids and STDs)
Tanzania: Call for Joint Efforts in Combating HIV/Aids
[Daily News]Zanzibar -THE administrative officer for North Pemba, Mr Khamis Salum Mohamed, has urged everyone to join hands in addressing the scourge of HIV/ Aids. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Aspen, Cipla among winners in $860 mln South Africa aids drug tender
Aspen Pharmacare was awarded a 2.5 bn contract, India's Cipla a 2 bn deal, US-based Mylan won a 2.8 bn share in the tender. (Source: The Economic Times Healthcare and Biotech News)
Zimbabwe: The Politics of Sikhala's Facebook 'Aids' Diagnostic Kit
[New Zimbabwe]Opposition politics in Zimbabwe always falls short because niggling issues that require a lot of fine tuning before they can reach the standards required to govern. The main criticism against the MDC inclusive of all its fragments is the lack of an alternative shadow policy strategy and their tendency to point fingers and to always oppose just for the sake of opposing without presenting solutions or suggestions. The issue of political immaturity is what has been holding Zimbabwe back in a lot of ways. (Source: AllAfrica News: HIV-Aids and STDs)
Zimbabwe: HIV Has Claimed 500,000 Lives - Govt Official
[New Zimbabwe]AT LEAST half a million Zimbabweans have died of HIV/AIDS related illnesses over the past 16 years, a senior government health official has said. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: Coca-Cola, Partners Friends Africa to Celebrate World Aids Day
[Independent (Lagos)]Lagos -In commemoration of World AIDS Day 2014, Coca-Cola Nigeria Limited in partnership with Friends Africa (Friends of the Global Fund Africa), a pan-African NGO, organised a week long HIV/AIDS outreach in Lagos, enabling about 4,000 persons to take the HIV test. (Source: AllAfrica News: HIV-Aids and STDs)
Zimbabwe: Home Demolition Victims Denied ARVs
[New Zimbabwe]VICTIMS of Epworth housing demolitions are being denied HIV/AIDS treatment by local health authorities because they do not have medical records which they claim were destroyed during the forced evictions. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
FDA to ease longtime ban on blood donations from gay men
For the first time since the early days of the AIDS epidemic, gay and bisexual men will be permitted to donate blood under rules set for release next year by the Food and Drug Administration. (Source: Los Angeles Times - Science)
Why Even A 12-Month Ban On Blood Donations From Gay Men Makes No Sense
The Food and Drug Administration on Tuesday ended the lifetime ban on blood donations from men who have sex with men. But the agency said it would continue to bar donations by men who have had a sexual encounter with another man in the previous year, disappointing prominent gay rights groups and HIV/AIDS researchers, who called the yearlong waiting period medically unnecessary and unscientific. The FDA said the change "will better align the deferral period with that of other men and women at increased risk for HIV infection." ?The one-year deferral notion constitutes symbolic progress, but is not any more warranted than a lifetime ban," wrote Dr. Eli Adashi, professor of medical science at Brown University's Warren Alpert Medical School, in an email to HuffPost. The 31-year-old ban ...
CDC's Mission: Protecting the Health of Americans
There is no doubt Ebola will rank as the biggest public health story of 2014, both here in the United States and around the world: more people sickened by Ebola than ever before in history, more people dying, and more understanding of how the health of one nation affects the health of us all. Today, more than 170 of CDC's top health professionals are in West Africa working to stop the current Ebola epidemic and leave behind stronger public health systems. Many hundreds more support their work at home. Leaving behind better capacities to find, stop, and prevent health threats in affected countries will help prevent the next epidemic, protecting the people of West Africa and the world. I am proud of the work that CDC employees are doing to contribute to this challenge. But there is sti...
Mood and Anxiety Disorders as Early Manifestations of Medical Illness: A Systematic Review
Conclusions: Physicians may not pursue medical workup of cases that appear to be psychiatric in nature. They should be alerted that disturbances in mood, anxiety and irritability may antedate the appearance of a medical disorder.Psychother Psychosom 2015;84:22-29 (Source: Psychotherapy and Psychosomatics)
Mycobacterium avium?intracellulare brain abscesses in an HIV-infected patient
We present a case of a multiple MAC brain abscesses, confirmed by brain biopsy and culture, in a patient with AIDS. The patient's initial symptoms were weakness, confusion and headaches. The patient was initially treated for toxoplasmosis and pyogenic bacterial brain abscesses with no resolution. Following treatment for MAC the patient's abscesses resolved. (Source: IDCases)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
2015 Theme Issue on Trauma Associated With Violence and Human Rights Abuses Call for Papers
In August 2015, JAMA will publish a theme issue on violence and human rights with an emphasis on the causes, consequences, and management of trauma. Violence is an important cause of physical and emotional trauma, and the scope of trauma care is broad, including care for survivors of unintentional injuries as well as injuries resulting from many forms of violence. Injuries and violence cause 5.8 million deaths each year worldwide, accounting for about 10% of the world?s deaths, more than the number of deaths that result from malaria, tuberculosis, and AIDS combined. The primary causes of these 5.8 million deaths are road traffic crashes, suicide, and homicide, followed by falls, drowning, poisoning, burns, and war. In the United States, data from the Global Burden of Disease 2010 Study i...
Check the phone book: Testing information and communication technology (ICT) recall aids for personal network surveys
This study tested two recall aids for the name generator procedure via a randomized web experiment with 447 college students, eliciting their personal networks. Compared to participants solely presented with the name generator, participants being prompted and probed to consult records saved in their communication devices provided more comprehensive network data and more weak ties. Furthermore, these data were garnered without either a substantial increase in item nonresponse or a decrease in completion time for subsequent name interpreters. Thus, ICT recall aids are deemed cost-effective and context-neutral techniques to improve the recall accuracy of data collected by the name generator. (Source: Social Networks)
Navigating the Unknown: Shared Decision-Making in the Face of Uncertainty
ABSTRACT In shared decision-making (SDM), patient and physician deliberate together on the basis of shared evidence, supporting the patient?s choice among multiple options, informed by her values and preferences. One factor complicating the implementation of SDM is uncertainty, which has long been recognized in medicine but perhaps not sufficiently addressed in the context of SDM. In order to ensure that SDM can be realistically applied to real-world clinical encounters, the issue of uncertainty should be recognized and explicitly incorporated into SDM strategies. Here we propose practical approaches, based in doctor?patient communication science and bioethics, that may be of help for incorporating the uncertainty factor into SDM in the context of the doctor-patient encounter....
African American Community Leaders' Policy Recommendations for Reducing Racial Disparities in HIV Infection, Treatment, and Care: Results From a Community-Based Participatory Research Project in Philadelphia, Pennsylvania
African Americans account for 45% of new HIV infections in the United States. Little empirical research investigates African American community leaders&rsquo; normative recommendations for addressing these disparities. Philadelphia&rsquo;s HIV infection rate is 5 times the national average, nearly 70% of new infections are among African Americans, and 2% of African Americans in Philadelphia are living with HIV/AIDS. Using a community-based participatory research approach, we convened focus groups among 52 African American community leaders from diverse backgrounds to solicit normative recommendations for reducing Philadelphia&rsquo;s racial disparities in HIV infection. Leaders recommended that (a) Philadelphia&rsquo;s city government should raise awareness about HIV/AIDS with media campai...
Risk Factors for Acquisition and Clearance of Oral Human Papillomavirus Infection Among HIV-Infected and HIV-Uninfected Adults
Human papillomavirus (HPV) causes the majority of oropharyngeal cancers in the United States, yet the risk factors for and natural history of oral HPV infection are largely unknown. In 2010&ndash;2011, a US-based longitudinal cohort study of 761 human immunodeficiency virus (HIV)-infected and 469 at-risk HIV-uninfected participants from the Multicenter AIDS Cohort Study and the Women's Interagency HIV Study was initiated. Semiannually collected oral rinses were evaluated for 37 HPV genotypes using the Roche LINEAR ARRAY HPV Genotyping Test (Roche Molecular Systems, Pleasanton, California), and factors associated with oral HPV incidence and clearance were explored using adjusted Wei-Lin-Weissfeld modeling. Through 2013, the 2-year cumulative incidence of any type of oral HPV infection was 3...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
FDA to ease ban on gay men donating blood
Lifetime ban on blood donations dated from early days of the AIDS crisis; major blood banks support move (Source: Health News: CBSNews.com)
Approval and Potential Use of Over-the-Counter HIV Self-Tests: The Opinion of Participants in a Street Based HIV Rapid Testing Program in Spain
Abstract HIV self-testing, not yet available in Spain, is a strategy thought to be able to increase the number of people tested and testing frequency. 3,373 attenders of a street-based HIV rapid-testing program gave their opinion on authorizing over-the-counter self-tests and a potentially shorter lead time if self-tests were available. 88.0 % of participants were in favor of authorization, 9.2 % had no clear opinion and 2.8 % were against. 54.6 % of men who have sex with men (MSM), 38.4 % of men who have sex with women and 36.3 % of women acknowledged a potential for lead time reduction. Potential lead time was associated with being ?35 years, having a university degree, never injected drugs, previous HIV tests and being concerned about an HIV positive result, and in MSM...
Up To Speed: Aetna faces lawsuit charging mail-order drug delivery is discriminatory (Video)
Advocacy group Consumer Watchdog has filed suit against Aetna claiming that the insurance company violates some patients' privacy by requiring certain medications be obtained through the mail. Specifically, the suit cites Aetna's (NYSE: AET) policy for drugs to treat people with HIV and AIDS, saying that requiring mail delivery of those medications heightens the risk of a privacy breach since mail sometimes gets dropped at the wrong address, and that, furthermore, mail delivery is not necessarily? (Source: bizjournals.com Health Care:Physician Practices headlines)
Up to speed: Aetna faces lawsuit charging mail-order drug delivery is discriminatory (Video)
Advocacy group Consumer Watchdog has filed suit against Aetna claiming that the insurance company violates some patients' privacy by requiring certain medications be obtained through the mail. Specifically, the suit cites Aetna's (NYSE: AET) policy for drugs to treat people with HIV and AIDS, saying that requiring mail delivery of those medications heightens the risk of a privacy breach since mail sometimes gets dropped at the wrong address, and that, furthermore, mail delivery is not necessarily? (Source: bizjournals.com Health Care:Physician Practices headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Up To Speed: Aetna faces lawsuit charging mail-order drug delivery is discriminatory
Advocacy group Consumer Watchdog has filed suit against Aetna claiming that the insurance company violates some patients' privacy by requiring certain medications be obtained through the mail. Specifically, the suit cites Aetna's (NYSE: AET) policy for drugs to treat people with HIV and AIDS, saying that requiring mail delivery of those medications heightens the risk of a privacy breach since mail sometimes gets dropped at the wrong address, and that, furthermore, mail delivery is not reliable enough? (Source: bizjournals.com Health Care:Hospitals headlines)
Up To Speed: Aetna faces lawsuit charging mail-order drug delivery is discriminatory (Video)
Advocacy group Consumer Watchdog has filed suit against Aetna claiming that the insurance company violates some patients' privacy by requiring certain medications be obtained through the mail. Specifically, the suit cites Aetna's (NYSE: AET) policy for drugs to treat people with HIV and AIDS, saying that requiring mail delivery of those medications heightens the risk of a privacy breach since mail sometimes gets dropped at the wrong address, and that, furthermore, mail delivery is not necessarily? (Source: bizjournals.com Health Care:Hospitals headlines)
Lawsuit: Aetna's mail-order drug delivery is discriminatory
Advocacy group Consumer Watchdog has filed suit against Aetna claiming that the insurance company violates some patients' privacy by requiring certain medications be obtained through the mail. Specifically, the suit cites Aetna's (NYSE: AET) policy for drugs to treat people with HIV and AIDS, saying that requiring mail delivery of those medications heightens the risk of a privacy breach since mail sometimes gets dropped at the wrong address, and that, furthermore, mail delivery is not necessarily? (Source: bizjournals.com Health Care:Hospitals headlines)
Up To Speed: Aetna faces lawsuit charging mail-order drug delivery is discriminatory (Video)
Advocacy group Consumer Watchdog has filed suit against Aetna claiming that the insurance company violates some patients' privacy by requiring certain medications be obtained through the mail. Specifically, the suit cites Aetna's (NYSE: AET) policy for drugs to treat people with HIV and AIDS, saying that requiring mail delivery of those medications heightens the risk of a privacy breach since mail sometimes gets dropped at the wrong address, and that, furthermore, mail delivery is not necessarily? (Source: bizjournals.com Health Care:Hospitals headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
South Africa: Silent Suffering - Men and HIV
[IPS]Johannesburg -Lungile Thamela knows how he got infected with HIV: through his reckless choice to have unprotected sex with his partner although he knew she was living with HIV. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: Global Fund Appoints Mouhamadou Diagne As Inspector General
[Global Fund]Geneva -The Board of the Global Fund to Fight AIDS, Tuberculosis and Malaria appointed Mouhamadou Diagne, a distinguished auditor and financial supervisor, as Inspector General. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: Nurse Charged for Infecting 100 Villagers in Cambodia
[Independent (Lagos)]A nurse has been charged with murder after being accused of causing the spread of HIV to more than 100 villagers in north-western Cambodia, a court official has said. (Source: AllAfrica News: HIV-Aids and STDs)
Developmental Lung Malformations in Children: Recent Advances in Imaging Techniques, Classification System, and Imaging Findings
Congenital lung anomalies represent a diverse group of developmental malformations of the lung parenchyma, arterial supply, and venous drainage, which may present anywhere from the prenatal period through adulthood. It is imperative for radiologists to be aware of imaging techniques and imaging appearance of these anomalies across the pediatric age range. This review presents the spectrum of these lesions that are often encountered in daily clinical practice. Each anomaly is discussed in terms of underlying etiology, clinical presentation, and imaging characterization with emphasis on the most up-to-date research and treatment. Knowledge of these areas is essential for accurate, timely diagnosis, which aids in optimizing patient outcomes. (Source: Journal of Thoracic Imaging)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
A practical approach to imaging the axilla
Abstract Imaging of the axilla typically occurs when patients present with axillary symptoms or newly diagnosed breast cancer. An awareness of the axillary anatomy is essential in order to generate an accurate differential diagnosis and guide patient management. The purpose of this article is to review the indications for axillary imaging, discuss the logistics of the scanning technique and percutaneous interventions, and present the imaging findings and management of a variety of breast diseases involving the axilla. Teaching points ? Knowledge of normal axillary anatomy aids in determining the aetiology of an axillary mass. ? The differential diagnosis of an axillary mass is broad and can be subdivided by t...
Towards ending HIV/AIDS among drug users in China
(Source: Addiction)
HIV epidemic among drug users in China: 1995?2011
ConclusionsWhile HIV prevalence and needle sharing among current injecting drug users in China have declined dramatically and are correlated with the scale?up of national harm reduction efforts, the recent, rapid increased use of ?nightclub drugs? presents a new challenge. (Source: Addiction)
Progress Toward Curing HIV Infections With Hematopoietic Stem Cell Transplantation
Combination antiretroviral therapy can suppress human immunodeficiency virus (HIV) infection but cannot completely eradicate the virus. A major obstacle in the quest for a cure is the difficulty in targeting and measuring latently infected cells. To date, a single person seems to have been cured of HIV. Hematopoietic stem cell transplantation (HSCT) preceded this cancer patient's long-term sustained HIV remission, but researchers have been unable to replicate this cure, and the mechanisms that led to HIV remission remain to be established. In February 2014, the National Institute of Allergy and Infectious Diseases sponsored a workshop that provided a venue for in-depth discussion of whether HSCT could be exploited to cure HIV in cancer patients requiring such procedures. Participants also ...
Improvements in HIV Care Engagement and Viral Load Suppression Following Enrollment in a Comprehensive HIV Care Coordination Program
Conclusions.&nbsp;Clients in comprehensive HIV care coordination for persons with evident barriers to care showed substantial and consistent improvement in short-term outcomes. (Source: Clinical Infectious Diseases)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Cerebrospinal Fluid Inhibitory Quotients of Antiretroviral Drugs in HIV-Infected Patients Are Associated With Compartmental Viral Control
Conclusions.&nbsp;Cerebrospinal fluid 95% inhibitory quotients may be used to compare antiretroviral drug compartmental exposure; they deserve longitudinal studies to assess the adequacy of CSF drug concentrations in treated HIV-infected patients. (Source: Clinical Infectious Diseases)
Editorial Commentary: Cerebrospinal Fluid Inhibitory Quotients of Antiretroviral Drugs
(Source: Clinical Infectious Diseases)
Nontuberculous Mycobacteria Infections in Immunosuppressed Hosts
Diseases and therapies that reduce cell-mediated immunity increase the risk of nontuberculous mycobacterial (NTM) disease. Extrapulmonary NTM disease, including disseminated, skin, and catheter-related disease, is more common in immunosuppressed than immunocompetent patients. Mycobacterium avium complex remains the most common cause of NTM infection, but rapid growers including Mycobacterium abscessus, Mycobacterium chelonae, and Mycobacterium fortuitum play an important role in skin and catheter-related infections. With the exception of antibiotic prophylaxis for AIDS patients, the prevention of NTM remains difficult. Management is complicated, involving restoration of immune function and removal of catheters in addition to treatment with species-specific antibiotics per current guideline...
Ready, steady, go (RSG): Addressing the needs of adolescents in transition from child to adult services
ConclusionsRSG is an effective tool for delivering optimal transition to adult services. (Source: European Respiratory Journal)
The death analysis of HIV-infected patients in the antituberculous hospital
Conclusion. 80% of HIV -infected patients with a tuberculosis had lethal outcomes because of the end-stage of a HIV - AIDS. (Source: European Respiratory Journal)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Modern social and clinical characteristics of miliary tuberculosis
Conclusions: The disease has subtle clinical manifestations, frequent HIV coinfection, and adverse outcomes. (Source: European Respiratory Journal)
The tale of two hospitals: Urban and suburban patients with tuberculosis and their outcomes
Conclusions: PTB patients in the two hospitals HS and HTAA -- located in urban and suburban parts of Malaysia respectively -- were different in their demographic characteristics, co-morbidities and drug-resistance profiles. There were more favourable outcomes in HTAA. (Source: European Respiratory Journal)
Usefulness of a myositis antibody immunoblot in diagnosis of connective tissue disease (CTD) related interstitial lung disease (ILD)
ConclusionIn ILD patients suspected to have occult CTD, enhancing the autoimmune screen by adding a myositis Ab immunoblot does aid MDT diagnosis and can alter decisions regarding biopsy and treatment. (Source: European Respiratory Journal)
Depression and Apathy Among People Living with HIV: Implications for Treatment of HIV Associated Neurocognitive Disorders
Abstract Depression and apathy are common among people living with HIV (PLWH). However, in PLWH, it is unclear whether depression and apathy are distinct conditions, which contribute to different patterns of disruption to cognitive processing and brain systems. Understanding these conditions may enable the development of prognostic indicators for HIV associated neurocognitive disorders (HAND). The present study examined substance use behavior and cognitive deficits, associated with depression and apathy, in 120 PLWH, using hierarchical regression analyses. Higher levels of depression were associated with a history of alcohol dependence and greater deficits in processing speed, motor and global cognitive functioning. Higher levels of apathy were associated with a history of cocaine...
Gender Abuse and Incident HIV/STI Among Transgender Women in New York City: Buffering Effect of Involvement in a Transgender Community
Abstract In a 3 year prospective study of 230 transgender women from the New York City Area, we further examined associations of gender-related abuse with HIV sexual risk behavior and incident HIV/STI, focusing here and the extent to which these associations are buffered by involvement in a transgender community. Largely consistent with the prior study, gender abuse was longitudinally associated with unprotected receptive anal intercourse (URAI) with casual and commercial sex partners, and the presumed biological outcome of this behavioral risk, new cases of HIV/STI. Both of these associations, gender abuse with URAI and HIV/STI, were significantly buffered by transgender community involvement (interaction effects). However, independent of these interaction effects, transgender c...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
?Was it a Mistake to Tell Others That You are Infected with HIV??: Factors Associated with Regret Following HIV Disclosure Among People Living with HIV in Five Countries (Mali, Morocco, Democratic Republic of the Congo, Ecuador and Romania). Results from a Community-Based Research
This study examined regret following HIV serostatus disclosure and associated factors in under-investigated contexts (Mali, Morocco, Democratic Republic of the Congo, Ecuador and Romania). A community-based cross-sectional study was implemented by a mixed consortium [researchers/community-based organizations (CBO)]. Trained CBO members interviewed 1,500 PLHIV in contact with CBOs using a 125-item questionnaire. A weighted multivariate logistic regression was performed. Among the 1,212 participants included in the analysis, 290 (23.9 %) declared that disclosure was a mistake. Female gender, percentage of PLHIV?s network knowing about one?s seropositivity from a third party, having suffered rejection after disclosure, having suffered HIV-based discrimination at work, perceived seriousne...
Smoking and HIV: A Risky CombinationSmoking and HIV: A Risky Combination
Antiretroviral therapy can extend lives for patients with HIV, but these gains can be wiped out by tobacco. Find out how you can help your HIV-positive patients quit smoking. CDC Expert Commentary (Source: Medscape Hiv-Aids Headlines)
New Slide Set: HIV Care Continuum for the United States and Puerto Rico
This slide set provides an overview of the HIV Care Continuum and how the data that supports various continua are gathered from CDC HIV surveillance systems. (Source: CDC HIV/AIDS Prevention)
Synergistic effects of food insecurity and drug use on medication adherence among people living with HIV infection
Abstract Food insecurity and drug use are closely connected in the context of poverty, and both have been suggested to interfere with HIV medication adherence among people living with HIV/AIDS (PLWH). Yet the potential interaction between the two factors on adherence has not been examined. For this study we collected longitudinal data on HIV medication adherence among PLWH in Atlanta, GA, to assess a possible synergistic effect between the two factors on HIV medication adherence. People informed about the study came to the research site and completed an audio computer-assisted self-interview and instructions for pill counting. Over the next 5 weeks participants received three unscheduled follow-up phone assessments conducted 2 weeks apart to collect pill counts of their HIV medi...
Uganda: Uganda HIV Cases Rise in Drivers
[EA Business]Kampala -The Strengthening Knowledge Management and Communications Capacity (KMCC) Project has found that HIV/AIDS cases continue to rise among fishing communities, long distance truck drivers, sex workers and miners. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Zambia: Stanchart Extends CSR to HIV/Aids
[Times of Zambia]THE health interventions by Standard Chartered Bank Zambia are paying desired dividends with a positive impact on the targeted communities. (Source: AllAfrica News: HIV-Aids and STDs)
Ethiopia: A New Direction for Global Health
[Reporter]It is easy to be discouraged about the state of international cooperation today, but global health remains an area in which the world has come together to do significant good. (Source: AllAfrica News: HIV-Aids and STDs)
Tanzania: Media Challenged On Supporting Tacaids' Anti-HIV Initiative
[Daily News]TANZANIA Commission for AIDS (TACAIDS) has called for media managers and editors all over the country to join in efforts that will help it achieve its newly announced 90-90-90 targets by 2020. (Source: AllAfrica News: HIV-Aids and STDs)
Antiretroviral treatment outcome in HIV-1-infected patients routinely followed up in capital cities and remote areas of Senegal, Mali and Guinea-Conakry.
CONCLUSIONS: We describe the ART outcome in capital and rural settings of Senegal, Mali and Guinea-Conakry. Our results in all of the three countries highlight the need to reinforce the ART adherence in order to minimize the occurrence of drug resistance. In addition, these findings provide additional evidence that the use of DBS as a sampling support could assist virological monitoring of patients on ART in remote areas. PMID: 25527333 [PubMed - in process] (Source: Journal of the International AIDS Society)
Characteristics and comprehensiveness of adult HIV care and treatment programmes in Asia-Pacific, sub-Saharan Africa and the Americas: results of a site assessment conducted by the International epidemiologic Databases to Evaluate AIDS (IeDEA) Collaboration.
CONCLUSIONS: This study serves as a baseline for on-going monitoring of the evolution of care delivery over time and lays the groundwork for evaluating HIV treatment outcomes in relation to site capacity for comprehensive care. PMID: 25516092 [PubMed - in process] (Source: Journal of the International AIDS Society)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Addressing gender inequality and intimate partner violence as critical barriers to an effective HIV response in sub-Saharan Africa.
CONCLUSIONS: There is a need to continue to accumulate evidence on the effectiveness and costs of different approaches to addressing gender inequality and violence as part of a combination HIV response. A clearer HIV-specific and broader synergistic vision of financing and programming needs to be developed, to ensure that the potential synergies between HIV-specific and broader gender-focused development investments can be used to best effect to address vulnerability of women and girls to both violence and HIV. PMID: 25499456 [PubMed - in process] (Source: Journal of the International AIDS Society)
Incidence and mortality of tuberculosis before and after initiation of antiretroviral therapy: an HIV cohort study in India.
CONCLUSIONS: The high incidence and mortality of TB seen in this study underscore the urgent need to improve the prevention and diagnosis of HIV-associated TB in India. We found substantial differences between TB before and after ART initiation. PMID: 25499123 [PubMed - in process] (Source: Journal of the International AIDS Society)
Anti-HIV Nanoparticles and Drug Exposure in Plasma CellsAnti-HIV Nanoparticles and Drug Exposure in Plasma Cells
Drug nanoparticles have the potential to overcome lymphatic drug insufficiency in HIV treatment. AIDS (Source: Medscape Today Headlines)
Interactions Between Pitavastatin and ART in HIVInteractions Between Pitavastatin and ART in HIV
What are the potential drug interactions between EFV or DRV/r in combination with pitavastatin? JAIDS: Journal of Acquired Immune Deficiency Syndromes (Source: Medscape Today Headlines)
Nigeria: Faith Leaders Want HIV/Aids Curtailed
[Independent (Lagos)]Senior Faith Leaders on Hope for HIV/AIDS have resolved to reduce the spread of the disease in Nigeria. Faith leaders are adherents of Islam and Christianity. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Funding AIDS programmes in the era of shared responsibility: an analysis of domestic spending in 12 low-income and middle-income countries
In this study, we attempt to answer this question. Methods We propose metrics to estimate domestic AIDS financing, using methods related to national prioritisation of health spending, disease burden, and economic growth. We apply these metrics to 12 countries in sub-Saharan Africa with a high prevalence of HIV/AIDS, generating scenarios of possible future domestic expenditure. We compare the results with total AIDS financing requirements to calculate the size of the resulting funding gaps and implications for donors. Findings Nearly all 12 countries studied fall short of the proposed expenditure benchmarks. If they met these benchmarks fully, domestic spending on AIDS would increase by 2·5 times, from US$2·1 billion to $5·1 billion annually, covering 64% of estimated future funding re...
Making the invisible, visible: a cross-sectional study of late presentation to HIV/AIDS services among men who have sex with men from a large urban center of Brazil
The prevalence of late presentation to HIV/AIDS services in men who have sex with men (MSM) in a Brazil urban center is higher than that noted in the global literature, with heterosexual men and older age individuals experiencing substantial barriers to care. (Source: BMC Public Health)
Challenges to Implementing Opioid Substitution Therapy in Ukrainian Prisons: Personnel Attitudes Toward Addiction, Treatment, and People With HIV/AIDS
HIV/AIDS incidence has decreased globally, but despite these encouraging trends, the epidemics in countries of the Former Soviet Union (FSU) in Eastern Europe and Central Asia continue to expand (Joint United Nations Programme on HIV/AIDS, 2014, UNAIDS, 2013). Ukraine is experiencing one of the most volatile HIV epidemics in the world, with an estimated 230,000 people living with HIV/AIDS (PLWHA), fueled primarily by people who inject drugs (PWIDs), although there is emerging evidence for a transition to the general population (Azbel et al., 2013; Bojko et al., 2013a; Joint United Nations Programme on HIV/AIDS (UNAIDS, 2014). (Source: Drug and Alcohol Dependence)
The Effects of Unilateral Adaptation of Hearing Aids on Symptoms of Depression and Social Activity Constraints of Elderly
Conclusion?Results show that, in the sample studied, unilateral hearing aid adaptation reduced social activity constraints and depression symptoms.[...]Thieme Publicações Ltda Rio de Janeiro, BrazilArticle in Thieme eJournals:Table of contents  |  Abstract  |  open access Full text (Source: International Archives of Otorhinolaryngology)
Sex workers clients in Italy: results of a phone survey on hiv risk behaviour and perception.
Conclusions. It is necessary a constant monitoring of the characteristics, behaviour, risk perception and testing of SW clients in Italian and other populations. PMID: 25522078 [PubMed - in process] (Source: Annali dell'Istituto Superiore di Sanita)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
HIV in Older Adults: A Guide for HIV Primary Care CliniciansHIV in Older Adults: A Guide for HIV Primary Care Clinicians
Dr Joseph McGowan provides a commentary to the New York State Department of Health AIDS Institute's guide to managing HIV in older adults. Medscape HIV/AIDS (Source: Medscape Hiv-Aids Headlines)
Tunisia: Security Situation in the Country Has Improved Significantly - Nouerfelli
[Tunis Afrique Presse]Kasbah -The security situation in the country has improved significantly, on the level of fight against terrorism, organised crimes, smuggling as well as concerning the borders and the neutrality of mosques, spokesperson of the government Nidhal Ouerfelli said Friday. (Source: AllAfrica News: HIV-Aids and STDs)
Assessing life styles, stressors and health status among a predominantly African American on-campus and off-campus student population - Hicks T, Herndon M, Hilton A, Attoh P, Armstrong V.
Students who attend college and reside on campus often have to contend with social problems such as alcohol and drug abuse, HIV/AIDS infection, courtship, sex and marriage, home and family and other social-psychological issues while trying to maintain acad... (Source: SafetyLit: All (Unduplicated))
[Establishment of a method for detecting peripheral blood circulating brain microvascular endothelial cells, a novel biomarker for blood-brain barrier injury].
CONCLUSION: We have successfully established a method for detecting peripheral blood cBMECs, which can be of important value in non-invasive assessment of BBB injury. PMID: 25537892 [PubMed - in process] (Source: Journal of Southern Medical University)
Comprehensiveness and programmatic vulnerability to stds/hiv/aids in primary care
This study aimed to identify programmatic vulnerability to STDs/HIV/AIDS in primary health centers (PHCs). This is a descrip - tive and quantitative study carried out in the city of São Paulo. An online survey was applied (FormSUS platform), involving administrators from 442 PHCs in the city, with responses received from 328 of them (74.2%), of which 53.6% were nurses. At - tention was raised in relation to program - matic vulnerability in the PHCs regarding certain items of infrastructure, prevention, treatment, prenatal care and integration among services on STDs/HIV/AIDS care. It was concluded that in order to reach comprehensiveness of actions for HIV/ AIDS in primary health care, it is necessary to consider programmatic vulnerability, in addition to more investment and reor - ganizat...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Gambia: NRA, GFPA Ink D20.8 Millions HIV/Aids, Road Safety Deal
[Daily Observer]The National Roads Authority (NRA) and the Gambia Family Planning Association (GFPA) Tuesday signed a sensitisation contract agreement as part of the implementation of the Trans-Gambia Corridor Project, amounting to D20, 813, 936 (twenty million, eight hundred and thirteen thousand, nine hundred and thirty six dalasis). (Source: AllAfrica News: HIV-Aids and STDs)
Zimbabwe: Govt to Create HIV Programme for Gays
[New Zimbabwe]THE government is going to create a specific HIV and AIDS programme targeting homosexuals and sex workers as a way of controlling the infection rate, a senior government official has revealed. (Source: AllAfrica News: Health and Medicine)
Alcohol disrupts sleep homeostasis - Thakkar MM, Sharma R, Sahota P.
Alcohol is a potent somnogen and one of the most commonly used "over the counter" sleep aids. In healthy non-alcoholics, acute alcohol decreases sleep latency, consolidates and increases the quality (delta power) and quantity of NREM sleep during the first... (Source: SafetyLit: All (Unduplicated))
Age-Related Eye Diseases and Recommendations for Low-Vision Aids
This article provides guidance on the most appropriate methods for communicating with patients who have limited vision. The 4 major causes of vision loss in this population are briefly reviewed. Low-vision aids are described and sources for these products are identified. (Source: Home Healthcare Nurse)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
HIV Diagnoses, Prevalence and Outcomes in Nine Southern States
Abstract A group of nine states in the Southern United States, hereafter referred to as the targeted states, has experienced particularly high HIV diagnosis and case fatality rates. To provide additional information about the HIV burden in this region, we used CDC HIV surveillance data to examine characteristics of individuals diagnosed with HIV in the targeted states (2011), 5-year HIV and AIDS survival, and deaths among persons living with HIV (2010). We used multivariable analyses to explore the influence of residing in the targeted states at diagnosis on deaths among persons living with HIV after adjustment for demographics and transmission risk. In 2011, the targeted states had a higher HIV diagnosis rate (24.5/100,000 population) than the US overall (18.0/100,000) and hi...
FDA Approves Stribild Efficacy Supplement
"On December 17, [2014], the Indications and Usage section of the STRIBILD (elvitegravir 150 mg/cobicistat 150 mg/emtricitabine 200 mg/tenofovir 300mg) label was updated to include patients who are virologically-suppressed (HIV-1 RNA &lt;50 copies/mL) on a stable antiretroviral regimen for at least 6 months with no history of treatment failure in order to replace their current regimen. Patients should have no known substitutions associated with resistance to the individual components of STRIBILD." &nbsp; More information is available: &nbsp; FDA: Press release AIDSinfo: Patient fact sheet on Stribild (Source: AIDSinfo At-a-Glance: Offering Information on HIV/AIDS Treatment, Prevention, and Research, A Service of the U.S. Department of Health and Human Services (DHHS))
Making Sense of the Transition From the Detroit Streets to Drug Treatment
In this article we consider the process of adjustment from active street sex work to life in structured substance abuse treatment among Detroit-area women who participated in a semicoercive program administered through a drug court. We examine this transition in terms of changes in daily routines and social networks, drawing on extensive qualitative data to illuminate the ways in which women defined their own situations. Using concepts from Bourdieu and Latour as analytical aids, we analyze the role of daily routines, environments, and networks in producing the shifts in identity that those who embraced the goals of recovery demonstrated. We conclude with a discussion of how the restrictive environments and redundant situations experienced by women in treatment could be paradoxically embra...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Local Discourse on Antiretrovirals and the Lived Experience of Women Living With HIV/AIDS in Thailand
Antiretrovirals (ARVs) have been seen as life-saving for HIV-positive people. However, ARVs have a darker side. Since 2000, many HIV-positive people in Thailand have received ARV treatments, but the understanding of ARVs and practices of medication-taking among HIV-positive women have not received much attention. We discuss local discourses employed by HIV-positive women and health work by these individuals in their attempts to adhere to ARVs restrictions. The local discourse of ARVs was ya tan rok AIDS "medications that could resist HIV/AIDS." ARVs provided hope for the women. Although the women were affected by the side effects of ARVs, they continued to take their medication to be able to live longer and perform their duties as mothers and carers. They were more concerned about the prac...
HIV treatment outcomes among people who inject drugs in Victoria, Australia
Background: People who inject drugs (PWID) are a key population affected by HIV. We assessed the effectiveness of HIV treatment among a clinical cohort of people living with HIV (PLHIV) diagnosed and referred for community-based antiretroviral therapy (ART) in Victoria, Australia. Methods: HIV notification data from a central statewide registry were matched with HIV clinical data from two large HIV treatment centers in Melbourne. We used survival analysis and Cox proportional hazard models to estimate time to AIDS and death for PWID in HIV treatment, compared with non-injectors, in the period 1996 ? 2008. Results: Of the 871 individuals, 93 (10.8%) had injecting as an exposure category and 671 (86%) had ever commenced ART. Adjusted analysis showed younger age, high initial CD4 cell count (...
Outcomes of second-line combination antiretroviral therapy for HIV-infected patients: a cohort study from Rio de Janeiro, Brazil
This study was conducted at the Instituto Nacional de Infectologia Evandro Chagas, Funda??o Oswaldo Cruz, at Rio de Janeiro, Brazio. For this study we included all patients who started first-line and second-line cART between 2000 and 2013. Second-line cART required a switch in the anchor drug of first-line cART. We evaluated time from second-line start to virologic failure and factors associated with increased risk of failure using multivariable Cox proportional hazards regression models. Results: Among the 1,311 patients who started first-line cART a total of 386 patients (29.5%) initiated second-line cART, out of which 35.0% and 60.6% switched from their first-line to their second-line cART when their HIV RNA was undetectable and after documented virologic failure, respectively. At secon...
Assessing the implementation effectiveness and safety of 1% tenofovir gel provision through family planning services in KwaZulu-Natal, South Africa: study protocol for an open-label randomized controlled trial
DiscussionThis protocol aims to address an important implementation question on whether FP services are able to effectively incorporate tenofovir gel provision for this at-risk group of women in South Africa. Provision of tenofovir gel to the women from the CAPRISA 004 trial meets the ethical obligation for post-trial access, and helps identify a potential avenue for future scale-up of microbicides within the public health system of South Africa.Trial registration: This trial was registered with the South Africa Department of Health (reference: DOH-27-0812-4129) and ClinicalTrials.gov (reference: NCT01691768) on 05 July 2012. (Source: Trials)
Predictors of adherence to antiretroviral therapy among people living with HIV and AIDS at the regional hospital of Sokode, Togo
Background: Adherence to antiretroviral therapy (ART) is beneficial in reducing the risk of emergence of HIV resistant strains. Adherence to ART among Persons Living with HIV/AIDS (PLWHA) is influenced by several factors related to the patient, the medication, and health facilities. In Togo, previous studies on adherence to ART have reported good adherence to ART during the first year of follow-up. However these may hide many disparities dues to cultural specificities which may differ across geographic areas of the country. We sought to determine the level of adherence to ART and document the associated factors among PLWHA at the regional hospital of Sokode, Togo. Methods: This was an analytical cross-sectional study conducted from May to July 2013 at the regional hospital of Sokode among ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
HIV Risk, Prevention, and Testing Behaviors Among Heterosexuals at Increased Risk for HIV Infection - National HIV Behavioral Surveillance System, 21 U.S. Cities, 2010.
This report summarizes unweighted data regarding HIV-associated risk, prevention, and testing behaviors from 9,278 heterosexual men and women interviewed in 2010 (the second cycle of NHBS data collection among heterosexuals). Results: The median age of participants was 35 years; 47% were men. The majority of participants were black or African American (hereafter referred to as black) (72%) or Hispanic/Latino (21%). Most participants (men: 88%; women: 90%) reported having vaginal sex without a condom with one or more opposite-sex partners in the past 12 months; approximately one third (men: 30%; women: 29%) reported anal sex without a condom with one or more opposite-sex partners. The majority of participants (59%) reported using noninjection drugs in the 12 months before the interview; nea...
Foreign-Born Persons Diagnosed with HIV: Where are They From and Where Were They Infected?
Abstract We sought to calculate rates of HIV diagnoses by area of birth among foreign-born persons in a high-incidence US city with many immigrants, and determine probable place of HIV acquisition. Data from the New York City HIV surveillance registry and American Community Survey were used to calculate HIV diagnosis rates by area of birth and determine probable place of HIV acquisition among foreign-born diagnosed in 2006?2012. HIV diagnosis rates varied by area of birth and were highest among African-born persons; absolute numbers were highest among Caribbean-born persons. Probable place of acquisition was a foreign country for 23 % (from 9 % among Middle Easterners to 43 % among Africans), US for 61 % (from 34 % among Africans to 76 % among South Americans), and not pos...
Scientists identify new, beneficial function of endogenous retroviruses in immune response
Endogenous retroviruses play a critical role in the body's immune defense against common bacterial and viral pathogens, researchers have found. Retroviruses are best known for causing contagious scourges such as AIDS, or more sporadically, cancer. (Source: ScienceDaily Headlines)
How llamas' unusual antibodies might help in the fight against HIV/AIDS
Most vaccines work by inducing an immune response characterized by neutralizing antibodies against the respective pathogen. An effective HIV vaccine has remained elusive so far, but researchers have continued to make progress, often employing innovative methods. A new study reports that a combination of antibodies from llamas can neutralize a wide range of circulating HIV viruses. (Source: ScienceDaily Headlines)
Sex, drugs and healthcare utilization among HIV+ patients: The role of marijuana
This study assessed the impact of MJ use on health outcomes, health care utilization, and risk-transmission behaviors in PLWHA. (Source: Drug and Alcohol Dependence)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Impact of marijuana use on memory in patients with HIV/AIDS: A systematic review
Aims: The most robust neurocognitive effect of cannabis use is memory impairment. Memory deficits are also high among persons living with HIV/AIDS, and cannabis is the most commonly used drug in this population. Yet research examining neurocognitive outcomes resulting from co-occurring cannabis and HIV is virtually non-existent. Thus, the primary objectives of this systematic review are to: (1) examine the literature specific to memory functioning in HIV-infected individuals; (2) examine the literature specific to memory functioning in cannabis users; (3) synthesize findings to propose a theoretical model; and (4) discuss directions for future research. (Source: Drug and Alcohol Dependence)
Understanding the HIV Care Continuum
This fact sheet explains the various approaches and data used to develop the HIV care continuum, how it is used to improve outcomes for people living with HIV in the United States and how it helps guide the nation?s response to HIV. (Source: CDC HIV/AIDS Prevention)
New Fact Sheet: Understanding the HIV Care Continuum
This fact sheet explains the various approaches and data used to develop the HIV care continuum, how it is used to improve outcomes for people living with HIV in the United States and how it helps guide the nation?s response to HIV. (Source: CDC HIV/AIDS Prevention)
Ebola 3.0
By Susan J. Blumenthal, M.D., and Jennifer Sherwood, M.P.H. The doctors, nurses and other health care workers who responded to the Ebola epidemic in West Africa were recently named Time magazine's "Person of the Year." The courageous individuals who dedicate their careers and risk their lives to help in times of global public health emergencies such as Ebola deserve this recognition. A new report shows that health care workers have more than 100 times the risk of being infected with Ebola in Sierra Leone as the general public there. The World Health Organization (WHO) estimates that 622 health care workers have acquired the virus and 346 of them have died in the affected countries. The recent death of a physician in the United States, who had been working in Sierra Leone and had tested ne...
Zimbabwe: Anti-Gay Legislation Could Defeat Goal to End Aids in Zimbabwe By 2015
[IPS]Harare -Despite a mandate to eradicate HIV/AIDS under the U.N. Millennium Development Goals (MDGs), Zimbabwe has done little or nothing to reduce the rate of infection among vulnerable gays and lesbians, say activists here. (Source: AllAfrica News: Health and Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Gambia: Gambia's HIV/Aids Percentage Stands At 1.9
[Daily Observer]The regional AIDS coordinator of the National Aids Secretariat (NAS) in the Lower River Region (LRR) has disclosed that the estimated number of people living with HIV/AIDS in The Gambia currently stands at 19,380, representing a percentage of 1.9. (Source: AllAfrica News: Health and Medicine)
Gambia: Kicking HIV/Aids Out
[Daily Observer]Stakeholders in our health service particularly those dealing in HIV/AIDS are still commemorating world AIDS which is often observed early in December. The day as we can recall is dedicated to raising money, increasing awareness, fighting prejudice and improving education. It s also important in reminding people that HIV has not gone away, and that there are many things still to be done and as well provides an opportunity for us all - individuals, communities and political leaders - to take action and ensu (Source: AllAfrica News: Health and Medicine)
Nigeria: APIN Produces Clinical Manual on HIV/Aids
[This Day]In an effort to improve the quality of healthcare professionals in HIV/AIDS practice, and provide knowledge on the management of the virus, a non-governmental organisation, Aids Prevention Initiative in Nigeria (APIN) has produced a clinical pharmacy training manual. (Source: AllAfrica News: HIV-Aids and STDs)
Zambia: Condomize! Protects Vulnerable Populations From HIV
[UNFPA]Lusaka -"Today, stigma and discrimination against people living with HIV and key populations remain widespread," said UNFPA Executive Director Dr. Babatunde Osotimehin, in his statement commemorating World AIDS Day. "We must ensure that anyone at risk of HIV and other sexually transmitted infections has access to condoms." (Source: AllAfrica News: Health and Medicine)
Botswana: HIV Infections Peak During Festive Season
[Botswana Daily News]Mahalapye -The Mahalapye Hospital public relations officer, Ms Pauline Bontle has expressed concern that HIV infections increase during the days leading to Christmas and New Year Holidays. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Zimbabwe: Teenage Pregnancies - the Sad Reality
[The Herald]More than 50 years ago, the mere mention of the word "sex" among teenagers would raise eyebrows and spark debate anywhere in Zimbabwe. Then, not even a single girl would indulge, or let alone fall pregnant. Today the mention of the same word, still cause as much anxiety, if not paranoia within the same age group. However, the increase in teenage pregnancies, unsafe abortions, sexually transmitted infections including HIV and Aids among teenagers' show that they have thrown caution to the wind and are indul (Source: AllAfrica News: Pregnancy and Childbirth)
Zimbabwe: Patients in Danger As ARVs Run Out
[New Zimbabwe]MORE than half a million people living with HIV and Aids are in danger as the public hospitals countrywide are experiencing shortages of the anti-retroviral (ARVs) drugs. (Source: AllAfrica News: Health and Medicine)
How llamas' unusual antibodies might help in the fight against HIV/AIDS
(PLOS) Most vaccines work by inducing an immune response characterized by neutralizing antibodies against the respective pathogen. An effective HIV vaccine has remained elusive so far, but researchers have continued to make progress, often employing innovative methods. A study published on Dec. 18 in PLOS Pathogens reports that a combination of antibodies from llamas can neutralize a wide range of circulating HIV viruses. (Source: EurekAlert! - Infectious and Emerging Diseases)
Global Life Expectancy Continues to Climb
Women have slightly greater gains than men, study finds (Source: The Doctors Lounge - Oncology)
Tobacco brief intervention training for chiropractic, acupuncture, and massage practitioners: protocol for the CAM reach study
DiscussionCAM practitioners provide care to significant numbers of tobacco users. Their practice patterns and philosophical approaches to health and healing are well suited for providing BIs. The CAMR study is examining the impact of the CAMR intervention on practitioners' tobacco-related practice behaviors, CAM patient behaviors, and documenting factors important to the conduct of practice-based research in real-world CAM practices. (Source: BMC Complementary and Alternative Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Osseointegration and its role in management of hearing loss
Publication date: December 2014 Source:Operative Techniques in Otolaryngology-Head and Neck Surgery, Volume 25, Issue 4 Author(s): James H Clark , Charles M. Stewart Osseointegration is a biological process by which a structural connection is created between living bone and the surface of a load-carrying implant. This phenomenon has been used in a range of medical interventions. In 1977, Tjellstrom reported on osseointegrated bone-anchored hearing device as an alternative to conventional bone-conducting hearing aids, which were required to be worn on a headband or a pair of glasses. Since that time, there has been significant development in surgical technique and device technology for bone-anchored hearing devices. A review of the current literature was conducted to describe these advanc...
Liver?related deaths in HIV?infected patients between 1995 and 2010 in France: the Mortavic 2010 study in collaboration with the Agence Nationale de Recherche sur le SIDA (ANRS) EN 20 Mortalité 2010 survey
ConclusionsThe proportion of LRDs among causes of death in HIV?infected patients seems recently to have reached a plateau after a rapid increase during the decade 1995?2005. LRDs remain a leading cause of death in this population, mainly as a result of hepatitis C virus (HCV) coinfection, HCC representing almost half of liver?related causes of death. (Source: HIV Medicine)
Global, regional, and national age?sex specific all-cause and cause-specific mortality for 240 causes of death, 1990?2013: a systematic analysis for the Global Burden of Disease Study 2013
Publication date: Available online 18 December 2014 Source:The Lancet Background Up-to-date evidence on levels and trends for age-sex-specific all-cause and cause-specific mortality is essential for the formation of global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013) we estimated yearly deaths for 188 countries between 1990, and 2013. We used the results to assess whether there is epidemiological convergence across countries. Methods We estimated age-sex-specific all-cause mortality using the GBD 2010 methods with some refinements to improve accuracy applied to an updated database of vital registration, survey, and census data. We generally estimated cause of death as in the GBD 2010. Key improvements included the addition of more recent v...
Physicians? Obligations to Patients Infected with Ebola: Echoes of AIDS
Society has an obligation to properly train and equip physicians, and physicians have an obligation to render care to patients even when risk is involved. (Source: American Journal of Obstetrics and Gynecology)
Comparative cost of illness analysis and assessment of health care burden of Duchenne and Becker muscular dystrophies in Germany
Conclusion: In conclusion, early assessments of economic aspects and the disease burden are essential to gain extensive knowledge of a distinct disease and above all play an important role in funding drug development programs for rare diseases. Therefore, our results may help to accelerate payer negotiations such as the pricing and reimbursement of new therapies, and will hopefully contribute to facilitating the efficient translation of innovations from clinical research over marketing authorization to patient access to a causative treatment. (Source: Orphanet Journal of Rare Diseases)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Physicians? obligations to patients infected with Ebola: echoes of acquired immune deficiency syndrome
Physicians across the United States are engaged in training in the identification, isolation, and initial care of patients with Ebola. Some will be asked to do more. The issue this viewpoint will address is the moral obligation of physicians to participate in these activities. In order to do so the implicit contract between society and its physicians will be considered, as will many of the arguments that are redolent of those that were litigated 30 years ago when acquired immune deficiency syndrome (AIDS) was raising public fears to similar levels, and some physicians were publically proclaiming their unwillingness to render care to those individuals. (Source: American Journal of Obstetrics and Gynecology)
Adherence level to and predictors of Option B+ PMTCT programme in Tigray, northern Ethiopia
The AIDS epidemic is one of the most destructive epidemics that the world has ever witnessed.1 Globally, an estimated 35.3 million adults and 3.2 million children under the age of 15 years were living with HIV in the year 2012. Sub-Saharan Africa accounts for the greatest share. With the rising HIV/AIDS prevalence, the number of children under 5 years of age infected with HIV is increasing. Mother-to-child transmission (MTCT) of HIV accounts for over 90% of these cases.1 The risk of HIV transmission from mother to child, without preventive interventions, ranges from 15% to 40%. (Source: International Journal of Infectious Diseases)
Antibodies Predict Scleroderma Renal Crisis
(MedPage Today) -- Antibody test aids assessing risk for this potentially lethal complication. (Source: MedPage Today Primary Care)
HIV-related Stigma Among an Urban Sample of Persons Living With HIV at Risk for Dropping Out of HIV-oriented Primary Medical Care
HIV-related stigma is one of the greatest barriers to preventing and ending the HIV epidemic. The purpose of our study was to examine HIV-related stigma among urban adults voluntarily seeking HIV-oriented primary medical care and at risk for dropping out after enrolling. The baseline cross-sectional analysis of perceived HIV-related stigma upon enrolling in care examined the level of HIV-related stigma and its sub-domains: personalized, disclosure, negative self-image, and public attitudes. Our study also identified precursors of HIV-related stigma and associated outcomes. (Source: Journal of the Association of Nurses in AIDS Care)
The Context and Experience of Becoming HIV Infected for Zimbabwean Women: Unheard Voices Revealed
Zimbabwean women are at high risk for HIV infection but often are not the focus of inquiry unless they are participants in controlled trials. In this phenomenological study, we interviewed 17 women living with advanced HIV infection to better understand their experiences and the aftermath of being diagnosed with HIV. Open-ended interviews were audiotaped, transcribed, translated into English, and analyzed. Two themes (living with suspicion of HIV infection and sensing the engulfing anguish of being HIV infected) emerged and were found to reflect the essence of the phenomena. (Source: Journal of the Association of Nurses in AIDS Care)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Deconstructing HIV-Related Stigma: A Dialogue With a Multidisciplinary Group of Experts
Despite clinical advances in the care of persons living with HIV (PLWH), HIV-related stigma remains a persistent issue, and evidence that stigma negatively impacts health outcomes for PLWH continues to grow. Not only has HIV-related stigma been implicated as a barrier for care initiation for PLWH (Pollini, Blanco, Crump, & Zuniga, 2011), but findings from a meta-analysis examining health and demographic correlates of stigma toward PLWH has revealed that the association of high HIV-related stigma with poor mental and physical health outcomes is significant and consistent across studies (Logie & Gadalla, 2009). (Source: Journal of the Association of Nurses in AIDS Care)
Ending HIV-Related Stigma: Nursing's Opportunity to Lead
Throughout history, persons living with a communicable disease have been labeled as deviants, ostracized, shunned by society, and even quarantined. In her classic book, AIDS and Its Metaphors, Susan Sontag (1998) asserted that HIV ? ?whose charge of stigmatization, whose capacity to create a spoiled identity? (p. 16) is far greater than any disease before it. HIV has made clear, like many prior communicable diseases, the complex intersection of culture, law, ethics, and science that has shaped the pandemic we know today (Brandt, 1988). (Source: Journal of the Association of Nurses in AIDS Care)
Table of Contents
(Source: Journal of the Association of Nurses in AIDS Care)
Board of Directors
(Source: Journal of the Association of Nurses in AIDS Care)
Masthead
(Source: Journal of the Association of Nurses in AIDS Care)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Cover 1
(Source: Journal of the Association of Nurses in AIDS Care)
Editorial Board
(Source: Journal of the Association of Nurses in AIDS Care)
New HIV Guideline Updates, Expands Prevention RecommendationsNew HIV Guideline Updates, Expands Prevention Recommendations
The CDC has published an updated and expanded guideline on preventing HIV transmission with adults and adolescents with HIV. Medscape Medical News (Source: Medscape ObGyn and Womens Health Headlines)
HIV/Hepatitis C Virus Coinfection ManagementHIV/Hepatitis C Virus Coinfection Management
The clinical guidelines are changing for the treatment of HIV/hepatitis C virus coinfection. HIV Medicine (Source: Medscape Today Headlines)
Renal Function Among ART-Naive, HIV-Infected PatientsRenal Function Among ART-Naive, HIV-Infected Patients
What is the prevalence of abnormal renal function among ART-naive, HIV-infected patients in Southeast Nigeria? Journal of the International Association of Providers of AIDS Care (Source: Medscape Today Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Combining social media, behavioral psychology could lead to more HIV testing
Social media such as Twitter and Facebook, combined with behavioral psychology, could be a valuable tool in the fight against AIDS by prompting high-risk individuals to be tested, research shows. Though there have been many experimental HIV testing interventions in international settings, none have used social media technologies, said one investigator. (Source: ScienceDaily Headlines)
The Unbroken Chain: Three Decades of HIV/AIDS Nursing The Unbroken Chain: Three Decades of HIV/AIDS Nursing
Read about the trailblazers who brought HIV out of the shadows and into a compassionate and progressive system of care. (Source: Medscape Hiv-Aids Headlines)
Elizabeth Glaser Pediatric AIDS Foundation selected to receive up to $63 million from UNITAID
(Elizabeth Glaser Pediatric AIDS Foundation) The Elizabeth Glaser Pediatric AIDS Foundation is pleased to announce that it has been selected by the UNITAID Executive Board to receive up to $63 million in funding to improve early infant diagnosis of HIV programs in nine African countries. This investment will pave the way for universal access to HIV testing and enable a ten-fold increase in HIV treatment, thus transforming the effort to end AIDS in children worldwide. (Source: EurekAlert! - Medicine and Health)
Delirium Transitions in the Medical ICU: Exploring the Role of Sleep Quality and Other Factors*
Conclusions: We found no association between daily perceived sleep quality ratings and transition to delirium. Infusion of benzodiazepine and/or opioid medications was strongly associated with transition to delirium in the ICU in mechanically ventilated patients and is an important, modifiable risk factor for delirium in critically ill patients. (Source: Critical Care Medicine)
Nigeria: Combating HIV/Aids Stigmatisation
[Independent (Lagos)]Abuja -This year's celebration of World AIDS Day on December 1 provided another opportunity for people globally to lend their voices to the fight against HIV/ AIDS as well as show support for people living with HIV/AIDS. The day is also meant to remember those who died as a result of the virus (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Changing use of traditional healthcare amongst those dying of HIV related disease and TB in rural South Africa from 2003 - 2011: a retrospective cohort study
Conclusions: There were large decreases in reported traditional healthcare use and increases in the sole use of biomedical treatment amongst those dying of HIV/AIDS and TB. No associations between socio-economic position, age or gender and the likelihood of traditional healthcare use were seen. Further qualitative and quantitative studies are needed to assess whether these figures reflect trends in healthcare use amongst the entire population and the reasons for the temporal changes identified. (Source: BMC Complementary and Alternative Medicine)
Hispanic/Latino Individuals Lack Sufficient HIV Treatment
With 3 times more Hispanic or Latino individuals receiving an HIV diagnosis each year compared with non-Hispanic white individuals, greater levels of care targeted to this demographic group are needed to meet the goals of the National HIV/AIDS Strategy. (Source: JAMA)
Getting Ahead of Illness: Using Metaphors to Influence Medical Decision Making
Conclusions. Describing the flu virus metaphorically in decision aids or information campaigns could be a simple, cost-effective way to increase vaccinations against the flu. (Source: Medical Decision Making)
Does antiretroviral therapy for HIV reduce the risk of developing multiple sclerosis?
In 2011, a case was reported in which a patient with multiple sclerosis (MS) and HIV was treated with antiretroviral therapy (ART)&mdash;he did not experience MS-related deficits for over a decade.1 This prompted researchers in Denmark (Nex&oslash; et al) to examine the association between MS and HIV using population-based databases. Although they found a reduced incidence of MS in HIV-positive individuals compared with the general population, their study did not achieve a conventional level of statistical significance.2 I was recently asked to review the Gold et al study,3 which has answered the Danish researchers&rsquo; call for a larger study to investigate whether HIV, or its treatment, has a protective effect on the development of MS. Similar to the original Danish study, Gold et al u...
HIV and lower risk of multiple sclerosis: beginning to unravel a mystery using a record-linked database study
Conclusions HIV infection is associated with a significantly decreased risk of developing MS. Mechanisms of this observed possibly protective association may include immunosuppression induced by chronic HIV infection and antiretroviral medications. (Source: Journal of Neurology, Neurosurgery and Psychiatry)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Cost?effectiveness of rapid hepatitis C virus (HCV) testing and simultaneous rapid HCV and HIV testing in substance abuse treatment programs
ConclusionsOn?site rapid hepatitis C virus and HIV testing in substance abuse treatment programs is cost?effective at a &lt;$100?000/quality?adjusted life year threshold. (Source: Addiction)
A Prognostic Clinicopathologic Classification of Pituitary Endocrine Tumors
Pituitary endocrine tumors are considered as benign. However, clinical and pathological data favor their consideration as more than an endocrinological disease. Using data from a retrospective case-control study of 410 patients, with 8 years of follow-up, the authors have validated a new clinicopathologic classification of pituitary tumors. This classification is based on tumor size, immunohistochemical type, and grade based on the assessment of invasion and proliferation, and it provides a prognostic value for predicting postoperative disease-free outcome or recurrence/progression status. This classification aids the identification of patients presenting with pituitary tumors that have a high risk of recurrence and enable construction of personalized therapies. (Source: Endocrinology and ...
Inter? and intrarater reliability of the Chicago Classification in pediatric high?resolution esophageal manometry recordings
Conclusions & InferencesInter? and intrarater reliability of software?based CC diagnosis of pediatric HRM recordings was high overall. However, experience was a factor influencing the diagnosis of some motility disorders, particularly DES and achalasia. Automated software?based Chicago Classification (CC) aids in the diagnosis of pediatric esophageal motility disorders with high inter? and intrarater reliability. However, the clinical diagnosis of achalasia and distal esophageal spasm is less reliable. (Source: Neurogastroenterology and Motility)
Understanding HIV infection for the design of a therapeutic vaccine. Part II: Vaccination strategies for HIV.
Authors: de Goede AL, Vulto AG, Osterhaus AD, Gruters RA Abstract HIV infection leads to a gradual loss CD4(+) T lymphocytes comprising immune competence and progression to AIDS. Effective treatment with combined antiretroviral drugs (cART) decreases viral load below detectable levels but is not able to eliminate the virus from the body. The success of cART is frustrated by the requirement of expensive lifelong adherence, accumulating drug toxicities and chronic immune activation resulting in increased risk of several non-AIDS disorders, even when viral replication is suppressed. Therefore, there is a strong need for therapeutic strategies as an alternative to cART. Immunotherapy, or therapeutic vaccination, aims to increase existing immune responses against HIV or induce de novo i...
Evolution of the syphilis epidemic among men who have sex with men
Marc M. Solomon, Kenneth H. Mayer This manuscript provides an overview of the evolution of the global syphilis epidemic among men who have sex with men (MSM). It chronicles the changes in syphilis epidemiology among MSM including its interface with the HIV/AIDS epidemic. Finally, it seeks to describe the recent resurgence of syphilis incidence in the 2000s among MSM after a prior sharp drop in cases in the 1990s and calls for innovative strategies to address the evolving epidemic. (Source: Sexual Health)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Syphilis on the Rise Among Gay, Bisexual Men: CDC
Rates of chlamydia dip for the first time in 30 years (Source: Fertility News - Doctors Lounge)
Dyslipidemia in HIV AIDS patients
Husain NE, Ahmed MH (Source: Therapeutics and Clinical Risk Management)
Increasing the use of second-line therapy is a cost-effective approach to prevent the spread of drug-resistant HIV: a mathematical modelling study.
Conclusions : While earlier treatment initiation will result in a predicted increase in the proportion of patients infected with drug-resistant HIV, the absolute numbers of patients infected with drug-resistant HIV is predicted to decrease. Increasing use of second-line treatment to all patients with confirmed failure on first-line therapy is a cost-effective approach to reduce TDR. Improving access to second-line ART is therefore a major priority. PMID: 25491351 [PubMed - in process] (Source: Journal of the International AIDS Society)
The Most Exciting Health Stories Of 2014
While 2014 will forever be known as the year of the world's biggest Ebola outbreak -- and the first cases of Ebola contracted in the United States -- the virus is just one of several impactful changes in our medical and personal health landscape. From cancer research breakthroughs to innovative food policies to strides in the search for an HIV vaccine, we're quite a bit further in our understanding of medicine than we were last year. Thanks to research in 2014... Your Fitness Tracker Data Could Lead To The Next Big Medical Discovery Your FitBit, Jawbone and other personal tracking devices and apps are logging every step you take, every bite you eat and every hour you sleep. All of that data is a potential treasure trove for health researchers, which is why University of California,...
Combining social media and behavioral psychology could lead to more HIV testing
This study was conducted in greater Lima, which reflects the low- and middle-income countries where low-cost interventions such as HOPE could help stem the spread of AIDS. Previous research by Young and colleagues demonstrated that the HOPE intervention increased participants? requests for testing, but was too small to determine the rates of actual testing. ?That pilot study was a good enough start showing the potential of using the HOPE intervention to change testing behavior,? he said. This study builds on the prior research by increasing the number of participants by about five times ? 556 participants compared to  112 ? and it was designed with a verifiable and observable endpoint allowing the researchers to gauge the rates at which participants followed through with reques...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Nigeria: Struggling to Care for Adolescents Living With HIV
[IPS]Lagos, Nigeria -HIV among teenagers is devastating families in Nigeria and elsewhere in Africa, where AIDS has become the No. 1 killer of adolescents. (Source: AllAfrica News: HIV-Aids and STDs)
Evidence for the Expansion of Pediatric Cochlear Implant Candidacy
ConclusionNon-traditional pediatric implant recipients derive significant benefit from cochlear implantation. A large-scale reassessment of pediatric cochlear implant candidacy, including less severe hearing losses and higher preoperative speech recognition, is warranted to allow more children access to the benefits of cochlear implantation. (Source: Otology and Neurotology)
Nigeria: Hiccups in Fight Against Malaria
[Guardian]DESPITE huge investments towards elimination of malaria in Nigeria by the Federal Government, the Roll Back Malaria (RBM) partners and Global Fund for AIDS TB and Malaria, say the country accounts for the bulk of the global deaths and new infections. (Source: AllAfrica News: Malaria)
Tanzania: Playing Down Extent of Aids Devastation 'In Favour' of Outbreaks
[Daily News]DESPITE recent proliferation of diseases like the Ebola virus in West Africa, the plague in Madagascar, the dengue fever in Tanzania and other parts of the world, HIV/AIDS still remains a great threat to mankind. (Source: AllAfrica News: HIV-Aids and STDs)
An Integrated Tiered Service Delivery Model (ITSDM) Based on Local CD4 Testing Demands Can Improve Turn-Around Times and Save Costs whilst Ensuring Accessible and Scalable CD4 Services across a National Programme.
CONCLUSION: The ITSDM offers improved local TAT by extending CD4 services into rural/remote areas with new Tier-3 or Tier-2/POC-Hub services installed in existing community laboratories, most with developed infrastructure. The advantage of lower laboratory CD4 costs and use of existing infrastructure enables subsidization of delivery of more expensive POC services, into hard-to-reach districts without reasonable access to a local CD4 laboratory. Full ITSDM implementation across 5 service tiers (as opposed to widespread implementation of POC testing to extend service) can facilitate sustainable 'full service coverage' across South Africa, and save&gt;than R125 million in HIV/AIDS programmatic costs. ITSDM hierarchical parental-support also assures laboratory/POC management, equipment mainte...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
More than 70 per cent of HIV-AIDS patients not diagnosed
An HIV AIDS affected person can live 10 years to 25 years after he is diagnosed to have the disease and is properly treated. (Source: The Economic Times)
Rwanda: One Couple's Joy At Overcoming HIV Stigma
[New Times]Josee nyiraneza was just in her prime, at the age 22, when she got the worst news of her healthlife: was diagnosed with HIV. (Source: AllAfrica News: HIV-Aids and STDs)
Multiple human papillomavirus infections are highly prevalent in the anal canal of human immunodeficiency virus-positive men who have sex with men
Conclusions: HIV+ MSM show a very high rate of HPV infections in the anal canal and those with type 16 exhibited a multiplicity of associated types. This study emphasizes the need for an early detection of HPV infections among HIV+ MSM in order to establish its utility to prevent anal neoplasia and cancer. (Source: BMC Infectious Diseases)
Epidemiology of exposure to HIV/AIDS risky conditions in healthcare settings: the case of health facilities in Gondar City, North West Ethiopia
Conclusion: This study found quite high prevalence of health care workers exposure to HIV/AIDS risky conditions in the health care settings in Gondar city. Therefore, effective and goal oriented educational programmes targeting at health care workers and establishment of surveillance systems for registering, reporting and management of occupational exposures in health care settings are quite important. (Source: Epidemiologic Perspectives and Innovations)
Immuno-virological and clinical impacts of treating cancer in patients living with HIV
Conclusions In PLHIV, cancer treatment increased the risk for prolonged CD4+ depletion and virological failure but had no impact on AIDS-related events when appropriate prophylaxes were implemented. (Source: Journal of Antimicrobial Chemotherapy)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Children affected by maternal HIV/AIDS: Feasibility and acceptability trial of the Children United with Buddies (CUB) intervention
Past research has shown that young children affected by maternal HIV present with elevated stress/anxiety and negative well-being. This pilot intervention for children aged 7&ndash;14 affected by maternal HIV targeted improving positive child&ndash;mother communication, improving HIV/AIDS knowledge and reducing anxiety (especially related to transmission), and lessening feelings of stigma. Each of the three child intervention sessions included behavioral skills training and a themed craft exercise; mothers attended an open discussion group while the children attended their sessions. Study participants were 37 child&ndash;mother pairs. The study design was a randomized two-group pretest-posttest experimental design. The intervention sessions were audiotaped for transcription. Results showed...
A stromal cell free culture system generates mouse pro?T cells that can reconstitute T?cell compartments in vivo
T?cell lymphopenia following BM transplantation or diseases such as AIDS result in immunodeficiency. Novel approaches to ameliorate this situation are urgently required. Herein, we describe a novel stromal cell free culture system in which Lineage?Sca1+c?kit+ BM hematopoietic progenitors very efficiently differentiate into pro?T cells. This culture system consists of plate?bound Delta?like 4 Notch ligand and the cytokines SCF and IL?7. The pro?T cells developing in these cultures express CD25, CD117, and partially CD44; express cytoplasmic CD3?; and have their TCR? locus partially D?J rearranged. They could be expanded for over 3 months and used to reconstitute the T?cell compartments of sublethally irradiated T?cell?deficient CD3??/? mice or lethally irradia...
Molecular diagnosis of cryptococcal meningitis in cerebrospinal fluid: comparison of primer sets for Cryptococcus neoformans and Cryptococcus gattii species complex
Conclusions These data suggest that the CN4/CN5 primer set was highly sensitive for the identification of C. neoformans/C. gattii species complex in cerebrospinal fluid samples from patients with clinical suspicion of cryptococcal meningitis. (Source: The Brazilian Journal of Infectious Diseases)
On optimal treatment regimes selection for mean survival time
In clinical studies with time?to?event as a primary endpoint, one main interest is to find the best treatment strategy to maximize patients' mean survival time. Due to patient's heterogeneity in response to treatments, great efforts have been devoted to developing optimal treatment regimes by integrating individuals' clinical and genetic information. A main challenge arises in the selection of important variables that can help to build reliable and interpretable optimal treatment regimes as the dimension of predictors may be high. In this paper, we propose a robust loss?based estimation framework that can be easily coupled with shrinkage penalties for both estimation of optimal treatment regimes and variable selection. The asymptotic properties of the proposed estimators are studied....
Protocol for a systematic review and meta-analysis of hepatitis C virus (HCV) prevalence and incidence in the Horn of Africa sub-region of the Middle East and North Africa
Discussion This proposed systematic review and meta-analysis aims to better describe HCV infection distribution across countries in the Horn of Africa sub-region of MENA; and between sub-population groups within each country. The study will provide empirical evidence necessary for researchers, policy-makers, and public health stakeholders to set research, policy, and programming priorities for HCV prevention, control, and treatment. Systematic review registration PROSPERO CRD42014010318 (Source: Systematic Reviews)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Scientists' unique system of oral vaccine delivery to address global health threats
Scientists have succeeded in describing and validating a unique system of oral vaccine delivery using a common bacteria found in the mouth. According to the World Health Organization, nine million people were diagnosed with tuberculosis in 2013, the latest year in which data is available, and 1.5 million people died from the disease. It is second only to HIV/AIDS in prevalence. (Source: ScienceDaily Headlines)
Infrequent HIV Testing and Late Diagnosis Among Black MSMInfrequent HIV Testing and Late Diagnosis Among Black MSM
Sexually active black men who have sex with men are not being tested for HIV according to the CDC guidelines. JAIDS: Journal of Acquired Immune Deficiency Syndromes (Source: Medscape Today Headlines)
Africa: UNAIDS Board Underlines Ending the Aids Epidemic By 2030 As Central to the Post-2015 Development Agenda
[UNAIDS]Geneva -The 35th meeting of the UNAIDS Programme Coordinating Board reaffirmed its commitment to ending AIDS as a public health threat by 2030 and encouraged United Nations Member States to push for this goal to be fully reflected in the final agreement on the post-2015 development agenda. (Source: AllAfrica News: Health and Medicine)
Zambia: Global Fund Move to Save U.S $100 Million
[Times of Zambia]THE Global Fund to Fight AIDS, Tuberculosis and Malaria is putting into place a new agreement for purchasing HIV medication that will save close to US$100 million over two years, money that can be reinvested in lifesaving drugs and programmes all over the world. (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: High Diarrhoea Cases in Mombasa - Ministry
[The Star]Pneumonia, diarrhoea and HIV-Aids are the leading causes of deaths in Mombasa, according to a situational analysis by the Health ministry. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Rwanda: Why Rwandan Men Are Rushing to Be Circumcised
[News of Rwanda]Emille Nzabahimana, a bar tender in Kigali, Rwanda's capital, is obsessed with spontaneous sexual adventures and over-drinking. (Source: AllAfrica News: HIV-Aids and STDs)
Zimbabwe: Matabeleland Tops in New HIV Infections
[The Herald]At least half of all new HIV infections in the country are from Matabeleland, a National Aids Council official has said. In an interview recently, NAC operations director Mr Raymond Yekeye said Bulawayo had the highest new HIV infections that accounted for 20,4 percent of the total infections while Matabeleland South and Matabeleland North provinces recorded 18,6 and 15,6 percent respectively. (Source: AllAfrica News: HIV-Aids and STDs)
Zimbabwe: Government Neglects HIV+ Infected Children, Report
[New Zimbabwe]WHILE Zimbabwe has made headway in the fight against HIV and AIDS the government has been found wanting when it comes to HIV infected children. (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: Mobile Phones for Sex Workers - Blessing or Curse?
[The Star]More and more sex workers these days use mobile phones to reach clients. This means prostitutes aren't stuck in brothels any more. Is the latest technology a boon or a curse? (Source: AllAfrica News: HIV-Aids and STDs)
Toxoplasmosis in immunocompromised patients in Iran: a systematic review and meta-analysis
This study included a systematic review and meta-analysis to comprehensively assess the seroprevalence rate of Toxoplasma infection in immunocompromised patients in Iran. Electronic English and Persian databases (PubMed, Google Scholar, ScienceDirect, Scopus, Magiran, Scientific Information Database [SID], IranMedex, and IranDoc), parasitology congresses, and projects and theses of Iranian medical universities, were systematically searched from 1997 to 2013 (published or unpublished data). In this paper, several studies that used serological methods for diagnosis of toxoplasmosis were selected. Analysis of seroprevalence estimates was pooled using a random-effects meta-analysis. Twenty-two studies, comprising 2,805 individuals, were included in the meta-analysis. Overall seroprevalence rat...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
3 indispensable digestive aids for the holiday season
(NaturalNews) As a society we tend to overeat and drink too much, often in the form of grains, sugar, dairy, and alcohol. This practice seems to be magnified during the holiday season, with family and work gatherings picking up and the pressure to create a buffet that impresses the... (Source: NaturalNews.com)
Occasional heroin use may worsen HIV infection
(Yale University) Researchers at Yale and Boston University and their Russian collaborators have found that occasional heroin use by HIV-positive patients may be particularly harmful to the immune system and worsens HIV disease, compared to persistent or no heroin use. The findings are published in the journal AIDS and Behavior. (Source: EurekAlert! - Medicine and Health)
Nigeria: Achieving an HIV/Aids-Free Generation
The objective is to provide a platform for the world to unite in the fight against HIV/AIDS. Part of the aim is also to ensure that governments and policy makers meet the HIV targets they set, stand by the commitments they made and mobilize the necessary resources for a world where people do not die of AIDS related ailments. For each World AIDS Day from 2005 to 2010, the theme was "Stop AIDS". The 2014 theme fo (Source: AllAfrica News: HIV-Aids and STDs)
Rwanda: Youth Warned Off Early Sex
[New Times]YOUTH have been urged to avoid vices that could endanger their lives, including abusing drugs and engaging in early or unprotected sex. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Evidence?based HIV pilot program for Chinese college students: Differences by gender
This study explored gender differences in the effectiveness of the translated VOICES (Video Opportunities for Condom Education and Safer Sex) intervention on the condom use intention, perceived benefits and barriers to condom use, condom use self?efficacy, and HIV/AIDS knowledge among Chinese students in a US university. We utilized a pretest/post?test quasi?experimental design and recruited 67 Chinese students at the local university. Participants viewed a 20?min video with Chinese subtitles, attended one 25?min small group discussion and condom interactive educational activity. Female participants showed significantly greater mean scores of perceived benefits and condom use self?efficacy, in comparison with male participants. Female participants also reported significantly hi...
Assessment of neonatal care in clinical training facilities in Kenya
Conclusions Basic resources are generally available, but there are deficiencies in key areas. Poor documentation limits the use of routine data for quality improvement. Significant opportunities exist for improvement in service delivery and adherence to guidelines in hospitals providing professional training. (Source: Archives of Disease in Childhood)
Electronic cigarettes: patterns of use, health effects, use in smoking cessation and regulatory issues
Conclusions: The cytotoxicity and long term health effects of e-cigarettes are unknown. Nevertheless the e-cigarette market continues to expand, largely driven by middle-aged smokers who claim to be using e-cigarettes in an attempt to reduce or quit smoking. E-cigarettes may have some potential as smoking cessation aids and, in the researchers' view, should therefore be subject to further research and regulation similar to other nicotine replacement therapies. (Source: Tobacco Induced Diseases)
Use of visual aids in presenting study results
SK Raina, V ChanderJournal of Postgraduate Medicine 2015 61(1):56-57 (Source: Journal of Postgraduate Medicine)
Using Provider Performance Incentives to Increase HIV Testing and Counseling Services in Rwanda
Publication date: Available online 12 December 2014 Source:Journal of Health Economics Author(s): Damien de Walque , Paul J. Gertler , Sergio Bautista-Arredondo , Ada Kwan , Christel Vermeersch , Jean de Dieu Bizimana , Agnès Binagwaho , Jeanine Condo Paying for performance provides financial rewards to medical care providers for improvements in performance measured by utilization and quality of care indicators. In 2006, Rwanda began a pay for performance scheme to improve health services delivery, including HIV/AIDS services. Using a prospective quasi-experimental design, this study examines the scheme's impact on individual and couples HIV testing. We find a positive impact of pay for performance on HIV testing among married individuals (10.2 percentage points increase). Paying for pe...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Will a quadruple multiplexed point-of-care screening strategy for HIV-related co-infections be feasible and impact detection of new co-infections in at-risk populations? Results from cross-sectional studies
Conclusions A quad multiplex POC strategy for HIV and co-infections was feasible to operationalise and preferred by patients in both settings. Many new infections were identified in Mumbai and accuracy improved with version 2 of the assay. Such a strategy will help expedite screening for co-infections, particularly where baseline screening is low. These findings are valuable to practitioners, researchers, policymakers and funders involved in initiatives for all four diseases with implications for scale-up. (Source: BMJ Open)
Effect of rapid HIV testing on HIV incidence and services in populations at high risk for HIV exposure: an equity-focused systematic review
Conclusions Rapid VCT in health facilities and communities was associated with a large increase in HIV-testing uptake and receipt of results. This has implications for WHO guidelines. The routine use of rapid VCT may also help avoid human rights violations among marginalised populations where testing may occur without informed consent and where existing stigma may create barriers to testing. (Source: BMJ Open)
Mediators of a smoking cessation intervention for persons living with HIV/AIDS
Cigarette smoking among persons living with HIV (PLWH) is a profound cause of morbidity and mortality (Lifson and Lando, 2012). Compared to the general population, PLWH are far more likely to be current smokers (Browning et al., 2013) and, subsequently, are confronted with numerous tobacco- and HIV-related health risks (Feldman and Anderson, 2013; Palella and Phair, 2011; Smith et al., 2010). In fact, PLWH who smoke cigarettes are at higher risk for acute bronchitis, bacterial pneumonia, pulmonary disease, non-AIDS and AIDS-defining cancers, and overall mortality (Burke et al., 2004; Crothers et al., 2005; Engels et al., 2006; Lifson et al., 2010). (Source: Drug and Alcohol Dependence)
p120 catenin is required for normal tubulogenesis but not epithelial integrity in developing mouse pancreas.
Authors: Hendley AM, Provost E, Bailey JM, Wang YJ, Cleveland MH, Blake D, Bittman RW, Roeser JC, Maitra A, Reynolds AB, Leach SD Abstract The intracellular protein p120 catenin aids in maintenance of cell-cell adhesion by regulating E-cadherin stability in epithelial cells. In an effort to understand the biology of p120 catenin in pancreas development, we ablated p120 catenin in mouse pancreatic progenitor cells, which resulted in deletion of p120 catenin in all epithelial lineages of the developing mouse pancreas: islet, acinar, centroacinar, and ductal. Loss of p120 catenin resulted in formation of dilated epithelial tubules, expansion of ductal epithelia, loss of acinar cells, and the induction of pancreatic inflammation. Aberrant branching morphogenesis and tubulogenesis were ...
Molecular diagnosis of cryptococcal meningitis in cerebrospinal fluid: comparison of primer sets for Cryptococcus neoformans and Cryptococcus gattii species complex.
CONCLUSIONS: These data suggest that the CN4/CN5 primer set was highly sensitive for the identification of C. neoformans/C. gattii species complex in cerebrospinal fluid samples from patients with clinical suspicion of cryptococcal meningitis. PMID: 25523072 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Malawi: Gertrude Mutharika's Beam Evokes International Attention
[Malawi24]As controversy still surrounds the revelations that Beautify Malawi Trust, run by Malawi's First Lady, Gertrude Mutharika got money from the National Aids Commission (NAC), international organisations have joined the calls for BEAM to return the money. (Source: AllAfrica News: HIV-Aids and STDs)
A systematic review on skin complications of bone-anchored hearing aids in relation to surgical techniques
Abstract A systematic review to study the skin complications associated with the bone-anchored hearing aid in relation to surgical techniques. The following databases have been searched: MEDLINE, EMBASE, the Cochrane Library , Google scholar and the PubMed. The literature search date was from January 1977 until November 2013. Randomised controlled trials and retrospective studies were included. Initial search identified 420 publications. Thirty articles met the inclusion criteria of this review. The most common surgical techniques identified were full-thickness skin graft, Dermatome and linear incision techniques. The result shows that dermatome technique is associated with higher rate of skin complications when compared to linear incision and skin graft techniques. Based on t...
Africa: Aids Response Is Leaving African Men Behind
[IPS]Nairobi -Mention gender inequality in AIDS and the fact that more women than men live with HIV pops up. But another, rarely spoken about gendered difference is proving lethal to men with HIV. (Source: AllAfrica News: HIV-Aids and STDs)
Zimbabwe: UNAIDS Goals Too Ambitious for Zimbabwe
[Zimbabwe Independent]AS Zimbabwe observed World Aids Day (December 1) the just- released UNAids set of global Aids treatment and prevention goals to be reached by 2030 have been described as an ambitious target difficult to meet for the country because of a deep resource gap at the global level. (Source: AllAfrica News: HIV-Aids and STDs)
Spike in Tiny Number of Gay Men on PrEP Abandoning Condoms Hardly Represents 'All' Gay Men
A Dec. 8 blog post in the San Francisco Business Times has sparked another furor over gay men using the HIV drug Truvada to prevent infection with the deadly virus. "San Francisco men shed condoms in favor of Gilead's HIV prevention pill," alleges the title of SFBT reporter Ron Leuty's opinion piece. Leuty reported on a survey of men in a Kaiser Permanente AIDS-prevention program. More than 500 are taking Truvada once a day as pre-exposure prophylaxis (PrEP). Leuty called the 45-percent increase among men in the study not using condoms "eye-popping" -- which it is. Clearly these men aren't heeding the Centers for Disease Control and Prevention's recommendation to use condoms in addition to taking the drug. But it's a serious stretch to project the behavior of about 90 men on PrEP in this...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Individualized Texting for Adherence Building (iTAB): Improving Antiretroviral Dose Timing Among HIV-Infected Persons with Co-occurring Bipolar Disorder
Abstract HIV+ persons with co-occurring bipolar disorder (HIV+/BD+) have elevated rates of medication nonadherence. We conducted a 30-day randomized controlled trial of a two-way, text messaging system, iTAB (n = 25), compared to an active comparison (CTRL) (n = 25) to improve antiretroviral (ARV) and psychotropic (PSY) adherence and dose timing. Both groups received medication adherence psychoeducation and daily texts assessing mood. The iTAB group additionally received personalized medication reminder texts. Participants responded to over 90 % of the mood and adherence text messages. Mean adherence, as assessed via electronic monitoring caps, was high and comparable between groups for both ARV (iTAB 86.2 % vs. CTRL 84.8 %; p = 0.95, Cliff?s d = 0.01) and PSY (iTAB 7...
Scientific/Clinical Member Nominations Are Now Being Accepted for the Department of Health and Human Services (HHS) Panel on Antiretroviral Guidelines for Adults and Adolescents
The HHS Panel on Antiretroviral Guidelines for Adults and Adolescents (or the Panel) is accepting nominations for new scientific/clinical members with expertise in HIV medicine.The Panel is seeking candidates with expertise in HIV clinical research and clinical care. Panel members critically evaluate new information and prepare guidelines revisions. The candidates should be recognized experts in their areas of interest. The successful candidates will serve a 4-year term beginning April 2015, with potential for reappointment for an additional term. The Panel is a Working Group of the Office of AIDS Research Advisory Council of the National Institutes of Health. The Panel is composed of over 40 members who are clinicians, researchers, academicians, HHS representatives, and community repres...
Community Member Nominations Are Now Being Accepted for the Department of Health and Human Services (HHS) Panel on Antiretroviral Guidelines for Adults and Adolescents
The HHS Panel on Antiretroviral Guidelines for Adults and Adolescents (or the Panel) is accepting nominations for new community members who represent the demographic diversity of the HIV epidemic in the United States. Selected candidates may assist the Panel in identifying and addressing aspects of HIV treatment that are unique to their constituencies. The candidate shall have knowledge and involvement in issues related to management of HIV-infected adults and adolescents, as evidenced by experience in HIV treatment education/advocacy or clinical/public policy initiatives related to HIV treatment. The successful candidates will serve a 4-year term beginning April 2015, with potential for reappointment for one additional term. &nbsp; The Panel is a Working Group of the Office of AIDS Rese...
CDC Releases Recommendations for HIV Prevention with Adults and Adolescents with HIV in the United States, 2014
The Centers for Disease Control and Prevention (CDC), the Health Resources and Services Administration (HRSA), the National Institutes of Health (NIH), the American Academy of HIV Medicine, the Association of Nurses in AIDS Care, the International Association of Providers of AIDS Care, the National Minority AIDS Council, and the Urban Coalition for HIV/AIDS Prevention Services issued&nbsp;Recommendations for HIV Prevention with Adults and Adolescents with HIV in the United States, 2014. This guideline updates and expands on Recommendations for Incorporating HIV Prevention into the Medical Care of Persons Living with HIV &nbsp;which was published in 2003 by CDC, HRSA, NIH, and the HIV Medicine Association of the Infectious Diseases Society of America. &nbsp; The new guideline compiles new a...
A decade of researching the social aspects of HIV and AIDS
Publication date: 13?19 December 2014 Source:The Lancet, Volume 384, Issue 9960 Author(s): Lesley Doyal (Source: The Lancet)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Diurnal profiles of pedometer-determined physical activity in chronically ill and mobility-limited older adults: a cross-sectional study
Conclusions: This is the first study to explore pedometer-determined diurnal profiles of physical activity in chronically ill and mobility-limited older adults. Prolonging periods of elevated physical activity in the afternoon while respecting individual daily routine and commitments could be one option for facilitating the integration of physical activity and for making it a habit in older adults' daily lives. The use of a walking aid seems to be an indicator for a quite low activity plateau during the second half of the day. People who use walking aids should be motivated to increase their physical activity during afternoon; this might help to increase the overall low physical activity level of this vulnerable subgroup of older adults. (Source: BMC Public Health)
Toward improved anti-cryptococcal drugs: novel molecules and repurposed drugs.
Authors: Krysan DJ Abstract Cryptococcosis is one of the most important fungal infections of humans. It primarily, but not exclusively, afflicts people with compromised immune function. Cryptococcosis is most commonly caused by Cryptococcus neoformans var. grubii with C. neoformans var. neoformans and C. gatti also contributing to the disease. Cryptococcosis is primarily manifested as meningoencephalitis although pneumonia occurs frequently as well. Globally, the burden of disease is highest among those living with HIV/AIDS and is one of the most common causes of death in this patient population. Cryptococcal meningitisis almost invariably fatal if untreated. The current gold standard therapy is amphotericin B combined with 5-flucytosine. Unfortunately, this therapy has significant...
HIV Positive and Pregnant
According to journalist Heather Boerner, author of Positively Negative: Love, Pregnancy, and Science?s Surprising Victory Over HIV, the options for creating a healthy family keep growing and now include both pregnancy and adoption.read more (Source: Psychology Today Parenting Center)
Twenty Years Later: Ebola, AIDS, BSE and NCDs&#8212;What Have We Learned?
(Source: Journal of Health Communication)
Survey Leads to More Study of CA HIV-Prevention Drug UsersSurvey Leads to More Study of CA HIV-Prevention Drug Users
Some men report having more sex without condoms after starting on a daily pill to prevent HIV, according to an unpublished survey of 90 patients from one California healthcare provider. Reuters Health Information (Source: Medscape Medical News Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Establishment of Normal Reference Intervals for CD3(+), CD4(+), CD8(+), and CD4(+) to CD8(+) Ratio of T Lymphocytes in HIV Negative Adults from University of Gondar Hospital, North West Ethiopia.
Conclusion. The overall CD3(+) T lymphocytes reference interval in the current study was wide; low CD4(+) T lymphocytes, CD4 to CD8 ratio, and high CD8(+) T lymphocytes values were observed. PMID: 25485147 [PubMed - as supplied by publisher] (Source: AIDS Research and Treatment)
Liberia: 'HIV, Ebola Threaten Liberia's Growth'
[NEWS]The National AIDS Commission says challenges being posed by HIV and Ebola are serious threats to the country's growth. (Source: AllAfrica News: HIV-Aids and STDs)
[Perspectives] A decade of researching the social aspects of HIV and AIDS
My active involvement with HIV research began in 2005, after Professor Jane Anderson invited me to talk about gender to health workers involved in HIV services in the UK. Over coffee afterwards she discussed her desire to find out more about the lives of the African women for whom she was providing clinical care. I was keen to help, using my knowledge of qualitative research in the sociology of health. We, therefore, planned a collaborative study of the experiences of African women living with HIV who were receiving health care in a London hospital. (Source: LANCET)
[Comment] Ebola and human rights in west Africa
The fear caused by the Ebola outbreak in west Africa, which is projected to infect some 20?000 people, is understandable. However, the disproportionate measures recently adopted in some of the affected countries are a cause for concern. Some 25 years ago, Jonathan Mann, then Director of WHO's Global Programme on AIDS, warned world leaders alarmed at the relentless spread of HIV: (Source: LANCET)
Changes in Metabolic Syndrome Status After Initiation of Antiretroviral Therapy
Conclusions: One in 5 ART-naive subjects met criteria for MetS at ART initiation. Although more than half of these individuals continued to have MetS after 96 weeks of ART, 37% with MetS at ART initiation no longer met criteria for MetS; this decrease was driven largely by increases in HDL cholesterol. (Source: JAIDS Journal of Acquired Immune Deficiency Syndromes)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Rwanda: Leverage Infrastructure for HIV/Aids Prevention and Care to Combat Cancer
[New Times]On December 1, Rwanda, like the rest of the world, marked the World Aids Day and the country hosted the 2014 International HIV Research Conference in the same week. (Source: AllAfrica News: HIV-Aids and STDs)
Southern Africa: Adolescents Born With HIV Must Be Told Their Status
[Key Correspondents]"I think it was a miracle that I lost my sight because after that I realised there is more in my body than being blind." (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: UNAIDS Advocates More Domestic Funding to Tackle HIV/Aids in Nigeria
[Guardian]DR BILALI Camara, UNAIDS Country Director, has said that Nigeria needs more domestic funding to effectively tackle HIV/AIDS epidemic in the country. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: Global Fund News Flash
[Global Fund]Speaking Up for Sex Workers (Source: AllAfrica News: HIV-Aids and STDs)
Africa: New Approach On Buying HIV Drugs Will Save U.S.$100 Million
[Global Fund]Geneva -The Global Fund to Fight AIDS, Tuberculosis and Malaria is putting into place a new agreement for purchasing HIV medication that will save close to US$100 million over two years, money that can be reinvested in lifesaving drugs and programs all over the world. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Central African Republic: Red Cross Launches Country-Wide Mosquito Net Distribution Campaign to Tackle Malaria
[IFRC]Bangui/Geneva -A nationwide campaign to distribute 2.2 million mosquito nets in Central African Republic has been launched by the International Federation of Red Cross and Red Crescent Societies (IFRC), with support from the Global Fund to Fight AIDS, Tuberculosis and Malaria. (Source: AllAfrica News: Malaria)
Zimbabwe: Young Zimbabwean Spreads the Word On Living Positively
[Key Correspondents]Life for Kelvin Makura has been a tale of two challenges to which he has adapted in a positive way: living with both HIV and a physical disability resulting from stunted growth. (Source: AllAfrica News: HIV-Aids and STDs)
Uh Oh, It's Flu Season! What You Need to Know About Flu Vaccination
Media reports from just about every corner of the country are cautioning that Americans could be in for a particularly intense flu season this year, with many medical experts encouraging folks not to delay getting their flu shots. The flu season is not only here -- it could last until as late as May of next year according to the CDC. With this in mind, it is helpful to review a few basics that could help keep you, your family and your friends and neighbors feeling at their best during this winter's seasonal outbreaks of the flu. Who's at Risk? The flu is a respiratory infection that can cause serious, sometimes life-threatening complications for older adults, children and people with weakened immune systems. Getting a flu shot is one of the best ways to protect from serious flu-related ...
La cryptococcose : une étiologie potentielle d?ulcération faciale
Discussion La cryptococcose devrait être considérée comme une étiologie potentielle d?une ulcération faciale chronique chez un patient atteint de sida. La recherche d?autres localisations de la cryptococcose telles que celles du système nerveux central est impérative. Les examens mycologiques sont d?un grand intérêt pour le diagnostic dans les conditions de ressources limitées. Cutaneous cryptococcosis is an uncommon aetiology of chronic facial ulceration but which may be associated to a potentially lethal focus of cryptococcosis. Observation A 35-year-old AIDS patient under antiretroviral therapy, presented with a chronic facial ulceration. Histopathological examination of a biopsy of the facial ulceration showed an inflammatory granuloma and masses of yeasts. Mycologica...
Degloved foot sole successfully reconstructed with split thickness skin grafts
Conclusion This case-report illustrates that the reconstruction of a degloved foot sole with split-thickness skin grafts can be successful; a silicon inner sole was used to prevent stress lesions. (Source: International Journal of Surgery Case Reports)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
HIV Protease Inhibitor Use During Pregnancy Is Associated With Decreased Progesterone Levels, Suggesting a Potential Mechanism Contributing to Fetal Growth Restriction
Conclusions.&nbsp;Our data suggest that PI use in pregnancy may lead to lower progesterone levels that could contribute to adverse birth outcomes. (Source: The Journal of Infectious Diseases)
Intestinal Microbiota, Microbial Translocation, and Systemic Inflammation in Chronic HIV Infection
Conclusions.&nbsp;Patients who have chronic HIV infection and are receiving suppressive ART display intestinal dysbiosis associated with increased microbial translocation and significant associations between specific taxa and markers of microbial translocation and systemic inflammation. This was an exploratory study, the findings of which need to be confirmed. (Source: The Journal of Infectious Diseases)
Epigenetic Repression of Interleukin 2 Expression in Senescent CD4+ T Cells During Chronic HIV Type 1 Infection
The molecular mechanisms for IL2 gene&ndash;specific dysregulation during chronic human immunodeficiency virus type 1 (HIV-1) infection are unknown. Here, we investigated the role of DNA methylation in suppressing interleukin 2 (IL-2) expression in memory CD4+ T cells during chronic HIV-1 infection. We observed that CpG sites in the IL2 promoter of CD4+ T cells were fully methylated in naive CD4+ T cells and significantly demethylated in the memory populations. Interestingly, we found that the memory cells that had a terminally differentiated phenotype and expressed CD57 had increased IL2 promoter methylation relative to less differentiated memory cells in healthy individuals. Importantly, early effector memory subsets from HIV-1&ndash;infected subjects expressed high levels of CD57 and we...
CD8+ T Cells Maintain Suppression of Simian Immunodeficiency Virus in the Central Nervous System
Human immunodeficiency virus (HIV) accesses the brain early in infection and can lead to neurocognitive disorders. The brain can also serve as a viral reservoir, but how virus is controlled in the brain is unknown. To examine this, CD8-depleting monoclonal antibody was injected into the cerebrospinal fluid of rhesus monkeys with chronic simian immunodeficiency virus (SIV) infection. This treatment led to the rapid increase of SIV in the brain. Virus in the brain is maintained by active suppression from the host immune system. This dynamic interaction can be manipulated in efforts to control and eradicate virus from the brain and other reservoirs. (Source: The Journal of Infectious Diseases)
Enhanced In Vitro Transcytosis of Simian Immunodeficiency Virus Mediated by Vaccine-Induced Antibody Predicts Transmitted/Founder Strain Number After Rectal Challenge
Conclusions.&nbsp;Vaccine-induced antibody capable of enhancing transcytosis in vitro via FcRn may play a role in determining transmitted/founder strain number and infection outcomes following in vivo challenge. (Source: The Journal of Infectious Diseases)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
High Rates of Retention and Viral Suppression in the US HIV Safety Net System: HIV Care Continuum in the Ryan White HIV/AIDS Program, 2011
Conclusions.&nbsp;The RWHAP provides HIV medical care and support services for more than half a million poor and underinsured individuals living with HIV in the United States. Rates of retention and viral suppression are relatively high compared with other national estimates but demonstrate room for improvement, especially among youth and racial minorities. Additional improvements in retention and viral suppression will contribute to achieving the goals of the National HIV/AIDS Strategy and improve individual and public health. (Source: Clinical Infectious Diseases)
Editorial Commentary: Fixing a Hole in the HIV Safety Net
(Source: Clinical Infectious Diseases)
Acute HIV Infection Is Beneficial for Controlling Chronic Hepatitis B
Conclusions.&nbsp;These data suggest that the early effects of HIV infection improve the immune response against HBV. (Source: Clinical Infectious Diseases)
Effect of Deworming on Disease Progression Markers in HIV-1-Infected Pregnant Women on Antiretroviral Therapy: A Longitudinal Observational Study From Rwanda
Conclusions.&nbsp;Antihelminthic therapy reduces detectable viral load, and increases CD4 counts and hemoglobin levels in pregnant HIV-infected women with helminth coinfections receiving ART. (Source: Clinical Infectious Diseases)
Increased Virological Failure in Naive HIV-1-Infected Patients Taking Lamivudine Compared With Emtricitabine in Combination With Tenofovir and Efavirenz or Nevirapine in the Dutch Nationwide ATHENA Cohort
Conclusions.&nbsp;The use of emtricitabine instead of lamivudine as part of cART was associated with better virological responses. These findings are relevant for settings with extensive use of lamivudine and for settings where generic lamivudine will be available. (Source: Clinical Infectious Diseases)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Editorial Commentary: Comparative Efficacy of Lamivudine and Emtricitabine: Comparing the Results of Randomized Trials and Cohorts
(Source: Clinical Infectious Diseases)
Epidemiologic Features of AIDS in China, 2004-2013
(Source: Clinical Infectious Diseases)
Launching a virtual decision lab: development and field-testing of a web-based patient decision support research platform
Background: Over 100 trials show that patient decision aids effectively improve patients? information comprehension and values-based decision making. However, gaps remain in our understanding of several fundamental and applied questions, particularly related to the design of interactive, personalized decision aids. This paper describes an interdisciplinary development process for, and early field testing of, a web-based patient decision support research platform, or virtual decision lab, to address these questions. Methods: An interdisciplinary stakeholder panel designed the web-based research platform with three components: a) an introduction to shared decision making, b) a web-based patient decision aid, and c) interactive data collection items. Iterative focus groups provided feedback o...
The 12 Microresolutions of Christmas
We stand on the brink of the holiday season, a time when we generally eat, drink, and spend to excess. By New Year's Day we are so fed up (literally!) that we fervently resolve to change our ways. Why wait for the new year? Offered below are 12 easy microresolutions designed to promote holiday joy and reduce New Year's Day remorse. Pick two to practice until New Year's Day and you'll find that big benefits often come in small packages. Better to give than to receive; keep spending in check by making a microresolution not to buy gifts for yourself while shopping for others. If you've been too merry too often during past holidays, make your microresolution to drink a glass of water for every glass of alcohol to keep spirits high and hangovers (and weight gain) low. Holiday partying with...
Time's 'Person of the Year' Spotlights the Crucial Role of Ebola Survivors
This article was co-authored with Drs. Zena Stein, Jack Tocco, and Joanne Mantell of the HIV Center for Clinical and Behavioral Studies at Columbia University and the New York State Psychiatric Institute. (Source: Science - The Huffington Post)
Geospatial study identifies hotspots in deaths from HIV/AIDS, hepatitis C in Massachusetts
A new retrospective study by epidemiologists finds significant geographic disparities in HIV and hepatitis C related mortality in Massachusetts from 2002-2011. The study used geospatial techniques to identify hotspots and coldspots in the state. (Source: ScienceDaily Headlines)
Measuring the Success of Sustainable Development Indices in Terms of Reporting by the Global Press
Abstract A variety of indices have been applied to the performance of nation states, both for research and as aids to help guide policy and intervention. While the literature on indices is extensive, the focus to date has been almost entirely on technical issues of index creation. However the success of an index is arguably related at least in part to the use of that index by policy makers and managers. While cause-effect can be difficult to determine, one approach is to measure ?success? in terms of the reporting of indices by an intermediary group such as the media, and this paper assesses the reporting of 24 indices by newspapers worldwide until 2012. The results suggest that index success is influenced by a number of factors, including the time it has existed, its focus, e...
Africa: Public-Private Partnership Restores Hope for Aids-Free Generation
[State Department]Deborah L. Birx -This commentary by U.S. Global AIDS Coordinator Deborah L. Birx originally appeared on the Huffington Post website on December 9. There are no republication restrictions. (Source: AllAfrica News: Health and Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
A sneak peek behind the scenes of Boston Ballet?s ?The Nutcracker?
?I?m trying to decide whether Drosselmeyer?s mustache is real or fake. It?s too neat to be real, but it doesn?t look fake,? says 10-year-old Ellie Pohlig, who earned a coveted spot as a page in Boston Ballet?s 2014 &#8220;The Nutcracker.&#8221; A successful audition is an accomplishment for any dancer, but especially so for Ellie, who has high-frequency hearing loss. This type of partial deafness means Ellie has trouble hearing some consonants and sounds at higher octaves, like a woman?s voice. ?This was my third year trying out for The Nutcracker.&#8221; I was nervous at the auditions, but they went well,? says Ellie, who auditioned in a group of 50 dancers. Because Ellie is tall for a 10-year-old and Boston Ballet groups students according to height, there were fewer ...
Updated Fact Sheet: HIV Among African Americans
This fact sheet provides an overview of how HIV affects the African American population in the U.S. It has been updated with information from the 2012 Surveillance Report, as well as the 2012 Monitoring report. (Source: CDC HIV/AIDS Prevention)
Updated Spanish Language Fact Sheet: HIV Among African Americans
This fact sheet in Spanish provides an overview of how HIV affects the African American population in the U.S. It has been updated with information from the 2012 Surveillance Report, as well as the 2012 Monitoring report. (Source: CDC HIV/AIDS Prevention)
Updated HIV Among African American Gay and Bisexual Men
This fact sheet provides an overview of how HIV affects the African American Gay and Bisexual Men population in the U.S. It has been updated with information from the 2012 Surveillance Report, as well as the 2012 Monitoring report. (Source: CDC HIV/AIDS Prevention)
Updated Spanish Language Fact Sheet: HIV Among African American Gay and Bisexual Men
This fact sheet in Spanish provides an overview of how HIV affects the African American Gay and Bisexual Men population in the U.S. It has been updated with information from the 2012 Surveillance Report, as well as the 2012 Monitoring report. (Source: CDC HIV/AIDS Prevention)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Updated Fact Sheet: HIV Among Latinos
This fact sheet provides an overview of how HIV affects the Hispanic/Latino population in the U.S. It has been updated with information from the 2012 Surveillance Report, as well as the 2012 Monitoring report. (Source: CDC HIV/AIDS Prevention)
Updated Spanish Language Fact Sheet: HIV Among Latinos
This fact sheet in Spanish provides an overview of how HIV affects the Hispanic/Latino population in the U.S. It has been updated with information from the 2012 Surveillance Report, as well as the 2012 Monitoring report. (Source: CDC HIV/AIDS Prevention)
Updated Fact Sheet: HIV among Gay and Bisexual Men
This fact sheet provides an overview of how HIV affects the Gay and Bisexual Men population in the U.S. It has been updated with information from the 2012 Surveillance Report, as well as the 2012 Monitoring report (Source: CDC HIV/AIDS Prevention)
Updated Fact Sheet in Spanish: HIV among Gay and Bisexual Men
This fact sheet in Spanish provides an overview of how HIV affects the Gay and Bisexual Men population in the U.S. It has been updated with information from the 2012 Surveillance Report, as well as the 2012 Monitoring report. (Source: CDC HIV/AIDS Prevention)
Updated Fact Sheet: HIV Among African Americans
This fact sheet provides an overview of how HIV affects the African American population in the U.S. It has been updated with information from the 2012 Surveillance Report, as well as the 2012 Monitoring report. (Source: CDC HIV/AIDS Prevention)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Updated Spanish Language Fact Sheet: HIV Among African Americans
This fact sheet in Spanish provides an overview of how HIV affects the African American population in the U.S. It has been updated with information from the 2012 Surveillance Report, as well as the 2012 Monitoring report. (Source: CDC HIV/AIDS Prevention)
Updated HIV Among African American Gay and Bisexual Men
This fact sheet provides an overview of how HIV affects the African American Gay and Bisexual Men population in the U.S. It has been updated with information from the 2012 Surveillance Report, as well as the 2012 Monitoring report. (Source: CDC HIV/AIDS Prevention)
Updated Spanish Language Fact Sheet: HIV Among African American Gay and Bisexual Men
This fact sheet in Spanish provides an overview of how HIV affects the African American Gay and Bisexual Men population in the U.S. It has been updated with information from the 2012 Surveillance Report, as well as the 2012 Monitoring report. (Source: CDC HIV/AIDS Prevention)
Updated Fact Sheet: HIV Among Latinos
This fact sheet provides an overview of how HIV affects the Hispanic/Latino population in the U.S. It has been updated with information from the 2012 Surveillance Report, as well as the 2012 Monitoring report. (Source: CDC HIV/AIDS Prevention)
Updated Spanish Language Fact Sheet: HIV Among Latinos
This fact sheet in Spanish provides an overview of how HIV affects the Hispanic/Latino population in the U.S. It has been updated with information from the 2012 Surveillance Report, as well as the 2012 Monitoring report. (Source: CDC HIV/AIDS Prevention)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Updated Fact Sheet: HIV among Gay and Bisexual Men
This fact sheet provides an overview of how HIV affects the Gay and Bisexual Men population in the U.S. It has been updated with information from the 2012 Surveillance Report, as well as the 2012 Monitoring report (Source: CDC HIV/AIDS Prevention)
Updated Fact Sheet in Spanish: HIV among Gay and Bisexual Men
This fact sheet in Spanish provides an overview of how HIV affects the Gay and Bisexual Men population in the U.S. It has been updated with information from the 2012 Surveillance Report, as well as the 2012 Monitoring report. (Source: CDC HIV/AIDS Prevention)
Updated Fact Sheet: HIV Among African American Gay and Bisexual Men
This fact sheet provides an overview of how HIV affects the African American Gay and Bisexual Men population in the U.S. It has been updated with information from the 2012 Surveillance Report, as well as the 2012 Monitoring report. (Source: CDC HIV/AIDS Prevention)
The Recommendations for HIV Prevention with Adults and Adolescents with HIV in the United States, 2014
This guideline updates the 2003 guideline, "Incorporating HIV Prevention into the Medical Care of Persons Living with HIV: Recommendations of CDC, HRSA, NIH, and the HIV Medicine Association of the Infectious Diseases Society of America." It compiles numerous recommendations about biomedical, behavioral, and structural interventions to reduce HIV transmission from persons with HIV. The guideline is accompanied by three Summaries that list recommendations for each of the guideline?s audiences: clinical providers, nonclinical providers, and health department staff. (Source: CDC HIV/AIDS Prevention)
Role of csp genes in NaCl, pH, and ethanol stress response and motility in Clostridium botulinum ATCC 3502.
Authors: Derman Y, Söderholm H, Lindström M, Korkeala H Abstract Clostridium botulinum is a notable food pathogen and responsible for botulism due to production of botulinum neurotoxin. Strains of C. botulinum can adapt to and survive in stress conditions and food processing. The cold shock protein coding genes (csp) are involved in growth at low temperature, but they may also possess other functions. In this mutational analysis we show that cspB and cspC, but not cspA, are important for NaCl, pH and ethanol stress responses and for motility of C. botulinum ATCC 3502. In all NaCl concentrations tested, the cspB mutant had lower maximum growth rate and, together with the cspC mutant, a longer lag phase compared to the wild-type strain. At low pH, the cspB and cspC mutants showed...
Transition from control to elimination: impact of the 10-year global fund project on malaria control and elimination in china.
Authors: Wang RB, Zhang QF, Zheng B, Xia ZG, Zhou SS, Tang LH, Gao Q, Wang LY, Wang RR Abstract The Global Fund to Fight AIDS, Tuberculosis and Malaria (GFATM) supported a project on the control and elimination of malaria in People's Republic of China which was one of the biggest-scale international cooperation programmes to control malaria in the country during the past 10 years. The project promoted the effective implementation of the Chinese national malaria control programme. On the basis of epidemiologic data, an overview of the project activities and key performance indicators, the overall impact of the GFATM project was evaluated. We also reviewed relevant programme features including technological and management approaches, with a focus on best practice, innovations in imp...
On A Mission To Track The Flu And Other Infectious Diseases With A Thermometer
Inder Singh couldn&rsquo;t shake off a temperature of 103.8 degrees for one week during the summer of 2011. His doctor, an infectious disease specialist, was stumped. Desperate, Singh searched online for possible signs of a contagious illness in his New York area. There were none. Singh had worked in places like Uganda, Kenya, and India, haggling over the price of AIDS, malaria, and tuberculosis drugs with pharmaceutical companies, as an executive with the Clinton Health Access Initiative. &ldquo;I thought, &lsquo;wouldn&rsquo;t it be great to know what&rsquo;s going around?&rsquo;&rdquo; he says. The most recent flu reports from the Centers for Disease Control and Prevention are for the week ending November 29. Google Flu Trends are based on searches which sometimes overestimate the num...
On A Mission To Detect The Flu And Other Infectious Diseases With A Thermometer
Inder Singh couldn&rsquo;t shake off a temperature of 103.8 degrees for one week during the summer of 2011. His doctor, an infectious disease specialist, was stumped. Desperate, Singh searched online for possible signs of a contagious illness in his New York area. There were none. Singh had worked in places like Uganda, Kenya, and India, haggling over the price of AIDS, malaria, and tuberculosis drugs with pharmaceutical companies, as an executive with the Clinton Health Access Initiative. &ldquo;I thought, &lsquo;wouldn&rsquo;t it be great to know what&rsquo;s going around?&rsquo;&rdquo; he says. The most recent flu reports from the Centers for Disease Control and Prevention are for the week ending November 29. Google Flu Trends are based on searches which sometimes overestimate the num...
Nigeria: Many Challenges of Living With HIV in Nigeria (II)
[Guardian]"IN same vein I am strongly convinced and appreciative of the heavy investment the American people and government had put in our country's national HIV response. This is in no small measure of appreciation. I am also pained to see my country perform very poor in meeting agreements with partners. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Nigeria: HIV/Aids - New Presidential Plan Will Help
[This Day]Abuja -The Director of SURE-P HIV/AIDS Intervention, Dr Sabestine Wakdok has said Nigeria now stands a better chance to eliminate HIV/AIDS pandemic given the commitment of President Goodluck Jonathan through the President's Comprehensive Response Plan (PCRP). He stated this in Abuja at a forum to appraise the performance of the ongoing SURE-P projects around the country. (Source: AllAfrica News: HIV-Aids and STDs)
What makes orphans in Kigali, Rwanda, non-adherent to antiretroviral therapy? Perspectives of their caregivers.
CONCLUSIONS: Knowledge of orphan status is essential to elucidate the factors influencing ART adherence among HIV-positive children. In this qualitative study, we identified the orphan-related contextual factors that influenced ART adherence. Understanding the social context is important in dealing with the challenges to ART adherence among HIV-positive children. PMID: 25477050 [PubMed - in process] (Source: Journal of the International AIDS Society)
Nigeria: Governor Orji Inaugurates HIV/Aids Management Team in Abia
[This Day]Abia State Governor Theodore Orji has inaugurated a 24-man Team for the management of HIV\AIDS in the state. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: Lugbe Has Highest HIV Prevalence in Abuja - NACA
[Premium Times]Lugbe, a suburb of Abuja, has the highest prevalence of HIV/AIDS in Abuja, the Capacity Development Officer for SURE-P, Jummai Danuk, has said. (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: Mtwapa Gay Numbers Drop
[The Star]THE number of homosexuals living in Mtwapa town, Kilifi county has drastically gone down, as many fear being victimised. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Kenya: First Lady Meets Yvonne Chaka Chaka
[Kenya Presidency]First Lady Margaret Kenyatta today met South African singer Yvonne Chaka Chaka and they agreed to work together to fight the HIV/AIDS stigma. (Source: AllAfrica News: HIV-Aids and STDs)
Geospatial study identifies hotspots in deaths from HIV/AIDS and Hepatitis C in Massachusetts
(Tufts University, Health Sciences Campus) A new retrospective study by epidemiologists at Tufts finds significant geographic disparities in HIV and hepatitis C related mortality in Massachusetts from 2002-2011. The study, published in PLOS ONE, used geospatial techniques to identify hotspots and coldspots in the state. (Source: EurekAlert! - Medicine and Health)
Nasopharyngeal Burkitt lymphoma as an early AIDS manifestation
Publication date: November?December 2014 Source:Brazilian Journal of Otorhinolaryngology, Volume 80, Issue 6 Author(s): Juliana Gama Mascarenhas , Francisco Araújo Júnior , Thiago Villela Bolzan , Luis Carlos Gregório , Eduardo Macoto Kosugi (Source: Brazilian Journal of Otorhinolaryngology)
HIV Risk, Health, and Social Characteristics of Sexual Minority Female Injection Drug Users in Baltimore
Abstract Female injection drug users (IDU) who report sex with women are at increased risk for HIV and social instability, but it is important to assess whether these disparities also exist according to sexual minority identity rather than behaviorally defined categories. Within a sample of current IDU in Baltimore, about 17 % of female study participants (n = 307) identified as gay/lesbian/bisexual. In controlled models, sexual minorities were three times as likely to report sex exchange behavior and four times as likely to report a recent STI. Injection risk did not differ significantly, but sexual minority women reported higher prevalence of socio-economic instability, negative health indicators, and fewer network financial, material, and health support resources. There is a...
Partner-based adherence intervention for second-line antiretroviral therapy (ACTG A5234): a multinational randomised trial
Publication date: Available online 11 December 2014 Source:The Lancet HIV Author(s): Robert Gross , Lu Zheng , Alberto La Rosa , Xin Sun , Susan L Rosenkranz , Sandra Wagner Cardoso , Francis Ssali , Rob Camp , Catherine Godfrey , Susan E Cohn , Gregory K Robbins , Anthony Chisada , Carole L Wallis , Nancy R Reynolds , Darlene Lu , Steven A Safren , Lara Hosey , Patrice Severe , Ann C Collier Background Adherence is key to the success of antiretroviral therapy. Enhanced partner support might benefit patients with previous treatment failure. We aimed to assess whether an enhanced partner-based support intervention with modified directly observed therapy would improve outcomes with second-line therapy in HIV-infected patients for whom first-line therapy had failed. Methods We did a multic...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Health survey for England 2013
Since 2011, the survey has included questions about social care and these have been expanded in the 2013 survey, providing additional detail on patterns of care, payment, and aids and equipment used. (Source: NHS Networks)
Integration of community home based care programmes within national primary health care revitalisation strategies in Ethiopia, Malawi, South-Africa and Zambia: a comparative assessment
Conclusions: Countries may differ in the means to integrate and co-ordinate government and civil society agencies but the net result is expanded PHC capacity. In a context of changing health care demands, CHBC programmes are a vital mechanism for the delivery of primary health and social welfare services. (Source: Globalization and Health)
Understanding HIV infection for the design of a therapeutic vaccine. Part I: Epidemiology and pathogenesis of HIV infection.
Authors: de Goede AL, Vulto AG, Osterhaus AD, Gruters RA Abstract HIV infection leads to a gradual loss CD4(+) T lymphocytes comprising immune competence and progression to AIDS. Effective treatment with combined antiretroviral drugs (cART) decreases viral load below detectable levels but is not able to eliminate the virus from the body. The success of cART is frustrated by the requirement of expensive life-long adherence, accumulating drug toxicities and chronic immune activation resulting in increased risk of several non-AIDS disorders, even when viral replication is suppressed. Therefore there is a strong need for therapeutic strategies as an alternative to cART. Immunotherapy, or therapeutic vaccination, aims to increase existing immune responses against HIV or induce de novo i...
Stealth Anti-CD4 conjugated immunoliposomes with Dual Antiretroviral Drugs - Modern Trojan Horses to Combat HIV.
Authors: Ramana LN, Sharma S, Sethuraman S, Ranga U, Krishnan UM Abstract Highly active antiretroviral therapy (HAART) is the currently employed therapeutic intervention against AIDS where a drug combination is used to reduce the viral load. The present work envisages the development of a stealth Anti-CD4 conjugated immunoliposomes containing two anti-retroviral drugs (nevirapine and saquinavir) that can selectively home into HIV infected cells through the CD4 receptor. The nanocarrier was characterized using transmission electron microscopy, FTIR, differential scanning calorimetry, particle size and zeta potential. The cell uptake was also evaluated qualitatively using confocal microscopy and quantitatively by flow cytometry. The drug to lipid composition was optimized for maximum...
Kenya: HIV+ Women Claim They Were Sterilized By Govt
[Capital FM]Nairobi -Five HIV positive women have sued the Cabinet Secretary for Health, the county executive in charge of health in Nairobi and various health facilities for what they say was forced and coerced sterilisation. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Burundi: Discriminatory Laws Hinder Burundi's Response to HIV
[Key Correspondents]On Human Rights Day (10 December), Jean Claude Kamwenbusa reports on how the criminalisation of same sex relationships in Burundi is putting people's health and lives at risk. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: UNAIDS and Global Fund Sign Cooperation Agreement
[Global Fund]Geneva -UNAIDS and the Global Fund to Fight AIDS, Tuberculosis and Malaria signalled their strong partnership with a renewed cooperation agreement to help countries achieve Fast-Track targets to end the AIDS epidemic as a global health threat by 2030. (Source: AllAfrica News: HIV-Aids and STDs)
South Africa: Unions Should Rescue TAC, Says Achmat
[GroundUp]Former Treatment Action Campaign (TAC) leader, Zackie Achmat, has called on the trade unions to come to the rescue of TAC which has been mired in financial difficulties. (Source: AllAfrica News: HIV-Aids and STDs)
Botswana: Reproductive Health Team Exchange Ideas
[Botswana Daily News]Gaborone -Members of the regional project steering committee for the Sexual and Reproductive Health and Rights (SRHR) and HIV met in Botswana to review progress on the project. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: Strengthening the Office of the Inspector General
[Global Fund]The Global Fund's independent assurance structure, the Office of the Inspector General, is enhancing its work to support efforts to ensure that health products and services reach the people who need them most. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Nigeria: New Campaign to End Mum-to-Baby HIV Spread
[CAJ News]Lagos -A leading beverage maker and global health group have invited Nigerians to join efforts to help end mother-to-child transmission of HIV. (Source: AllAfrica News: HIV-Aids and STDs)
South Africa: Medicine Shortages Addressed in Gauteng
[SAnews.gov.za]Pretoria -The Gauteng Health Department has put measures in place to address the shortage of medicines in some of the hospitals and clinics in the province. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: Swaan Seeks Indigenous Commitment to HIV/Aids Advocacy
[Vanguard]The Society for Women andAIDS in Africa Nigeria, SWAAN, has urged indigenous companies and individuals to be committed in supporting government in the fight against HIV/AIDs in the country. (Source: AllAfrica News: HIV-Aids and STDs)
Rwanda: May Be HIV-Positive but Our Ability to Work Remains Sound
[New Times]When she was diagonised with HIV about four years ago, Agnes Mukantabana thought it was the end of the road. (Source: AllAfrica News: HIV-Aids and STDs)
Zambia: Young People Needed to Tackle HIV in Zambia
[Key Correspondents]Around 72 new HIV infections are recorded every day among Zambian youths and adolescents, which translates to three per hour, according to UNICEF. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
The Responsiveness, Content Validity, and Convergent Validity of the Measure Yourself Concerns and Wellbeing (MYCaW) Patient-Reported Outcome Measure
Conclusions. MYCaW scores were highly responsive to change, allowing personalized patient outcomes to be quantified; the qualitative coding framework appears generalizable across different integrative oncology settings and has broader coverage of patient-identified concerns compared with existing cancer-related patient-reported outcome measures. (Source: Integrative Cancer Therapies)
Multi-compartment compliance aids (MCAs): Application to the geriatric community
Publication date: Available online 19 October 2014 Source:European Geriatric Medicine Author(s): S. Edirisinghe , B.T. Raimi-Abraham , J.F.-M. Gilmartin , M. Orlu-Gul The high prevalence of co-morbidities in older people gives rise to an increasing number of prescribed medicine increasing the complexity of medicine management. Multi-compartment compliance aids and dispensing systems have the potential to organize the daily life of an older person. Various features of currently available compliance aids (such as multi-compartment design or an automated reminder function) have proved successful in assisting older patients to take their medication. This in turn enables them to manage their own often-complex drug regimens. Further investigations and collaborations between healthcare professi...
Factors Associated with Missed Psychiatry Visits in an Urban HIV Clinic
Abstract Psychiatric co-management is often required in HIV primary care. While rates and clinical impact of linkage and retention in HIV are well explored, fewer investigations focus specifically on linkage to psychiatry. In this investigation, we evaluate factors associated with linkage to psychiatric services using a retrospective cohort study of HIV-infected patients during a two-year observation period. Descriptive statistics depict patient characteristics, and logistic regression models were fit to evaluate factors associated with failure to establish care at the co-located psychiatry clinic following referral from HIV provider. Of 370 referred, 23 % did not attend a scheduled psychiatry appointment within 6 months of initial referral. In multivariable analysis, Non-white ...
Relationships between attitudes toward sexuality, sexual behaviors, and contraceptive practices among Chinese medical and nursing undergraduates
In this study, we investigated attitudes toward sexuality, the prevalence of sexual behaviors and contraceptive use among Chinese medical and nursing undergraduates, and relationships between attitudes toward sexuality and sexual and contraceptive practices among these participants. This was a descriptive, cross?sectional study carried out by using a Personal Attitude toward Sexuality Scale and Sexual and Contraceptive Questionnaire. The participants were recruited in the researcher's lectures. A total of 158 participants joined this study. Overall, Chinese medical and nursing undergraduates in this study held relatively conservative attitudes toward sexuality. The prevalence of sexually?active students was relatively low, and the percentage of contraceptive use among those sexually?...
Immunopatho-mechansims of liver fibrosis: targeting chemokine CCL2 mediated HIV:HCV nexus
Even in the era of successful combination antiretroviral therapy (cART), co-infection of Hepatitis C virus (HCV) remains one of the leading causes of non-AIDS-related mortality and morbidity among HIV-positive individuals as a consequence of accelerated liver fibrosis and end-stage liver disease (ESLD). The perturbed liver microenvironment and induction of host pro-inflammatory mediators in response to HIV and HCV infections, play a pivotal role in orchestrating the disease pathogenesis and clinical outcomes. How these viruses communicate each other via chemokine CCL2 and exploit the liver specific cellular environment to exacerbate liver fibrosis in HIV/HCV co-infection setting is a topic of intense discussion. Herein, we provide recent views and insights on potential mechanisms of CCL2 m...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
AIDS at 30: A History By Victoria A. Harden
(Source: American Journal of Epidemiology)
Life and Death on Your Terms
There comes a time when, despite your own and your family's wishes, beliefs or hope, death stares you in the face. A defining moment comes when you, as a family member, realize you are no longer prolonging a loved one's life but prolonging your loved one's dying process. I have learned that no one can tell you when that time is; it is a point that one must reach on their own. The decision to let go is usually made after endless hours at your loved one's bedside and recognizing the pain and suffering your loved one has endured. I have watched countless doctors and nurses attempt to convey the need to make a decision to a family, but the advice is usually offered in vain. The timing is personal to every family. Families can make various choices at the end of life. Different agencies can as...
Erratum to: Toward the Development of Preventive Interventions to Reduce HRSB, HIV/AIDS, and Multiple Problem Behaviors
(Source: Prevention Science)
Gambia: International World Aids Day HIV/Aids Among Children Decline By 40 Percent, 1.1 Million New Cases Prevented
[The Point]The United Nations International Children's Education Fund (UNICEF) has released a report that shows that the fight over HIV/AIDS among children is being won by the day; the agency reports that the incidence of HIV/AIDS among children has reduced by 40%, and to this end, about 1.1 million children have been prevented from contracting the disease between 2009 and 2013. (Source: AllAfrica News: Health and Medicine)
The Year in HIV: Prevention, Treatment, Complications, CureThe Year in HIV: Prevention, Treatment, Complications, Cure
Dr Paul Sax reviews the top stories in HIV medicine in 2014, with a focus on practice-changing clinical trial results. Medscape HIV/AIDS (Source: Medscape Today Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Namibia: 'How Alcohol Abuse Led Me to Getting HIV-Aids'
[New Era]Mariental -When sober, Paul Witbooi would not be able to talk to women. But a sip of alcohol would give him courage to propose to women. Witbooi's predicament was so known among his community that people started calling him an "old virgin". He found solace in alcohol, which he however abused to get involved with women. (Source: AllAfrica News: HIV-Aids and STDs)
Gambia: Aids Secretariat Receives Over U.S.$18 Million for PLHIV
[Daily Observer]The regional advisor, HIV/Nutrition at World Food Programme (WFP) Regional Bureau for West Africa based in Dakar, Senegal has disclosed that through the Global Fund, Round 8 (HIV), the National AIDS Secretariat of The Gambia has received a total funding of US$ 18,620,155 to accelerate access to prevention, treatment, care and support services which included nutritional assistance to PLHIV. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: Sokoto Rewards HIV/Aids Workers
[Daily Trust]Sokoto -Thirty-two volunteers in the fight against HIV/AIDS in Sokoto State were yesterday honoured by the state government. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: FG Launches Revised Workplace Policy On HIV/Aids
[This Day]By Linda Eroke The federal government has launched the revised National Workplace Policy and National Action Plan on Human Immune-deficiency Virus (HIV) and Acquired Immune Deficiency Syndrome (AIDS) in the country. (Source: AllAfrica News: HIV-Aids and STDs)
Botswana: Invest in HIV Interventions - Murphy
[Botswana Daily News]Maun -It is imperative to continue to invest in relevant interventions to achieve HIV control, says acting United States (US) Ambassador Chargé d'Affaires, Mr Michael Murphy. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Picture of HIV/AIDS
Title: Picture of HIV/AIDSCategory: ImagesCreated: 10/13/2010 2:19:00 PMLast Editorial Review: 12/9/2014 12:00:00 AM (Source: MedicineNet HIV General)
South Africa: Life-Saving Aids Medicine Out of Stock in Gauteng
[GroundUp]Hospitals throughout Gauteng ran out of essential medicines in recent weeks, including a life-saving drug for people with AIDS called amphotericin B. (Source: AllAfrica News: HIV-Aids and STDs)
Botswana: Reikeletseng Appreciates Efforts to Combat HIV/Aids
[Botswana Daily News]Gaborone -Botswana is under threat as the country continues to lose energetic people who should be the building blocks of the nation, Itekanele Health scheme managing director, Mr Solly Reikeletseng has said. (Source: AllAfrica News: HIV-Aids and STDs)
Is Grindr an Unprotected Anal Sex Finder?
Many Grindr users have unprotected anal sex increasing their risk for HIV.read more (Source: Psychology Today Sex Center)
Grindr: An Unprotected Sex Finder?
Many Grindr users have unprotected anal sex increasing their risk for HIV.read more (Source: Psychology Today Relationships Center)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
The changing pattern of ano-rectal cancer, squamous cell carcinoma of the eye, and Hodgkin's lymphoma as non-AIDS-defining cancers, by HIV status, in Tanzania over 11 years (2002-2012): a retrospective case-report study
Conclusions: The frequency and proportions of these three NADCs in Tanzania have increased over the past 11 years, as has the prevalence of HIV positivity amongst these NADC patients. The current and possibly increasing burden of NADCs in Tanzania and other low- and middle-income countries with high HIV rates should be a focus for future cancer prevention and control and HIV therapy programs. (Source: Infectious Agents and Cancer)
HIV-1 Tat induces DNMT over-expression through microRNA dysregulation in HIV-related non Hodgkin lymphomas
Conclusions: Our findings demonstrated that the ectopic expression of Tat was per se sufficient to determine DNMT up-regulation, based on microRNA down-regulation, and that this results in aberrant hypermethylation of target genes and microRNAs.These results point at a direct role for Tat in participating in uninfected B-cell lymphomagenesis, through dysregulation of the epigenetical control of gene expression. (Source: Infectious Agents and Cancer)
Long-term focus and prosocial?antisocial tendencies interact to predict belief in just world
Publication date: March 2015 Source:Personality and Individual Differences, Volume 75 Author(s): Carolyn L. Hafer , Alicia N. Rubel According to justice motive theory, individuals need to believe that the world is a just place where people generally get what they deserve (Lerner, 1977). Individuals are thought to need belief in a just world (BJW) in part because it gives them the confidence required to invest in long-term goals. However, BJW can only provide confidence that individuals will reap the rewards of their investments if they invest in their goals through prosocial means (e.g., Hafer, 2000). The current study provides evidence for this argument. Specifically, we examined individual differences in BJW, long-term goal focus, and prosocial?antisocial tendencies to test the hypot...
Latent and manifest empiricism in Q'eqchi' Maya healing: A case study of HIV/AIDS
Publication date: February 2015 Source:Social Science &amp; Medicine, Volume 126 Author(s): James B. Waldram , Andrew R. Hatala This paper presents a case study of the traditional treatment of a Q'eqchi' Maya man in southern Belize in 2011 who is suffering from AIDS-related sickness. The purpose is to detail the empirical nature of Q'eqchi' Maya medicine, distinguishing between manifest and latent empiricism, as evidenced in the healers evolving attempts to treat the patient in the absence of knowledge of his biomedical diagnosis. The paper argues for a more complete understanding of the empirical nature of much Indigenous healing, which parallels aspects of scientific medicine, and for better collaboration among traditional healers and biomedical practitioners in strongly Indigenous...
Portraying Mental Illness and Drug Addiction as Treatable Health Conditions: Effects of a Randomized Experiment on Stigma and Discrimination
Publication date: Available online 5 December 2014 Source:Social Science &amp; Medicine Author(s): Emma E. McGinty , Howard H. Goldman , Bernice Pescosolido , Colleen L. Barry Despite significant advances in treatment, stigma and discrimination toward persons with mental illness and drug addiction have remained constant in past decades. Prior work suggests that portraying other stigmatized health conditions (i.e., HIV/AIDS) as treatable can improve public attitudes toward those affected. Our study compared the effects of vignettes portraying persons with untreated and symptomatic versus successfully treated and asymptomatic mental illness and drug addiction on several dimensions of public attitudes about these conditions. We conducted a survey-embedded randomized experiment using a n...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Improving rates of cotrimoxazole prophylaxis in resource-limited settings: implementation of a quality improvement approach
Conclusions Quality management offers a data-driven method to improve the quality of HIV care in low resource countries. Application of improvement principles has been shown to be effective to increase the rates of CTX prophylaxis in national HIV programs in multiple countries. (Source: International Journal for Quality in Health Care)
Latinos in the United States on the HIV/AIDS care continuum by birth country/region: a systematic review of the literature
Twenty percent of Latinos with HIV in the US are unaware of their HIV status, 33% are linked to care late, and 74% do not reach viral suppression. Disparities along this HIV/AIDS care continuum may be present between various ethnic groups historically categorised as Latino. To identify differences along the HIV/AIDS care continuum between US Latinos of varying birth countries/regions a systematic review of articles published in English between 2002 and 2013 was conducted using MEDLINE, PsycINFO, and Web of Science. Studies that reported on one or more steps of the HIV/AIDS care continuum and reported results by birth country/region for Latinos were included. Latinos born in Mexico and Central America were found to be at increased risk of late diagnosis compared with US-born Latinos. No stu...
A qualitative analysis of barriers to accessing HIV/AIDS-related services among newly diagnosed HIV-positive men who have sex with men in China
In China, specific HIV/AIDS-related services have been in place since 2004. However, utilisation of these services remains limited among people living with HIV. We explored barriers to accessing HIV/AIDS-related services from the perspective of newly diagnosed HIV-positive men who have sex with men. We conducted repeated in-depth interviews with 31 newly diagnosed HIV-positive men who have sex with men, using the socio-ecological framework and thematic content analysis. Multiple barriers for utilisation of HIV/AIDS-related services were identified, including perceptions of subjective health and poor quality of services, mental and emotional health problems, lack of trust and understanding of the services on offer, low economic status, lack of insurance, and high medical fees, being refused...
Awareness and utilization of HIV services of an AIDS community-based organization in Kuala Lumpur, Malaysia
In Malaysia, homosexuality is illegal; little is known about access to HIV prevention services among Malaysian men who have sex with men (MSM). We analysed PT Foundation outreach data to describe the profiles among MSM who accessed PT Foundation services and to examine factors associated with being aware of PT Foundation and having visited the organization. A survey was administered during weekly outreach throughout Kuala Lumpur from March&ndash;December 2012. Pearson's Chi square tests were used to compare demographic and behavioural characteristics of participants who were and were not aware of the PT Foundation. Binary logistic regression was used to identify correlates of MSM visiting the PT Foundation among those who had heard of the organization. Of 614 MSM, this study found signific...
Discordant prevalence of Chlamydia trachomatis in asymptomatic couples screened by two screening approaches
This study was carried out to observe the effect of screening both members of an asymptomatic couple for Chlamydia trachomatis. First void urine samples were collected from 105 women and their male sex partners. Women were recruited for screening at a sexual health clinical setting (age 16&ndash;25 years), and home sampling screening options were used for men. Using PCR we detected seven positive C. trachomatis samples in women (6.6%) and five in men (4.6%). The concordant infection rate was 33% (3/9 couples). Routine urine screening of the female partner might result in substantial underestimation of the C. trachomatis prevalence within the couple, where perhaps 56% of the couples where at least one partner tested positive would remain undiagnosed. Screening both partners compared with wo...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Predictors of return rate for an HIV-positive result in a French Voluntary Counseling and Testing centre
This study proposed, in this centre, to describe the HIV newly-diagnosed patients over an 8-year period and to determinate risk factors for failure to return for a positive result. Higher risk for failure to return was found among the heterosexual subjects regardless of their socio-economic background. (Source: International Journal of STD and AIDS)
"Do you think your main partner has other sex partners?" A simple question provides insight into sexual risk in Jamaica
To estimate the association between a simple measure of sexual partner concurrency and sexually transmitted infection (STI) we conducted a cross-sectional population-based household survey (n = 1795) and targeted surveys of people at venues where people meet sexual partners (n = 1580) to ask about sexual behaviour. Persons interviewed at venues were tested for HIV, gonorrhoea, chlamydia, and trichomoniasis. We compared the association between STI and reporting a partner had other partners. More women than men reported their main partner had other partners. Thirteen percent of all women in the population-based survey and 14.4% in the targeted survey reported having one partner in the past 12 months and that partner had additional partners. STI prevalence was significantly associated with re...
Patients who return to care after tracking remain at high risk of attrition: experience from a large HIV clinic, Uganda
We determined the retention rate of patients infected with HIV who resumed care after being tracked at the Infectious Diseases Clinic (IDC) in Kampala, Uganda. Between April 2011 and September 2013, patients who missed their clinic appointment for 8&ndash;90 days were tracked, and those who returned to the clinic within 120 days were followed up. The proportion of patients retained among tracked patients, and those who resumed care before tracking started was compared. At 18 months of follow up, 33 (39%) of the tracked patients and 72 (61%) of those who had resumed care before tracking started were retained in care. The most important cause of attrition among the traceable was self-transfer to another clinic (38 [73%] patients), whereas among those who resumed care before tracking was loss...
Social-structural indices and between-nation differences in HIV prevalence
This study examined how social, economic, and political contexts that may represent the confluence of individual capabilities and environmental affordances or constraints are associated with national HIV prevalence. Based on social-ecological perspectives, we examined social-structural dimensions in relation to national HIV prevalence. The study identified six publicly available nation-level social, political, and economic indices and examined their associations with national 2009 HIV prevalence across 225 nations. National indices, (a) education expenditures, (b) unemployment rate, (c) homicide rate, (d) freedom of religion, and (e) women's social rights, altogether explained 43% of the variability in national HIV prevalence. Education expenditures, homicide rate, and freedom of religion ...
Sexual history taking in general practice: managing sexually transmitted infections for female sex workers by doctors and assistant doctors in Vietnam
Sexually transmitted infections (STIs) in Vietnam have been increasing. Control of STIs among female sex workers (FSWs) is important in controlling the epidemic. Effective STI control requires that physicians are skilful in taking sexual history for FSW patients. Three hundred and seventy-one physicians responded to a survey conducted in three provinces in Vietnam. The respondents were asked whether they asked FSW patients about their sexual history and information asked during sexual history taking. The respondents were also asked about their barriers for taking sexual history. Over one-fourth (27%) respondents always, over half (54%) respondents sometimes and 19% respondents never obtained a sexual history from FSW patients. Multivariable analysis revealed that factors associated with al...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Value of repeat testing using Cepheid GeneXpert CT/NG for indeterminate PCR results when diagnosing Chlamydia trachomatis and Neisseria gonorrhoeae
Nucleic acid amplification tests (NAATs) are the most sensitive method for diagnosing chlamydia and gonorrhoea. We use the COBAS 4800 CT/NG combined assay (Roche Molecular Diagnostics, CA, USA), and whilst the majority of samples yield definitive results, a small proportion are reported as indeterminate. In these instances, it is usual practice to request repeat samples which delays diagnosis. This audit was twofold: first to establish the proportion of indeterminate results with current NAAT testing requiring re-sampling. Second, to determine whether a second NAAT such as Cepheid GeneXpert CT/NG assay (Cepheid, CA, USA) could be used on initial indeterminate samples to resolve indeterminate results, therefore reducing need for repeat sampling. During 2012, 144/21,931 (0.66%) samples were ...
Extreme elevation of ferritin and creatine kinase in primary infection with HIV-1
We report an atypical case of primary HIV-1 infection with HIV-1 subtype C in a 61-year old Caucasian man who presented with extreme hyperferritinaemia without iron overload and marked elevation of serum creatine kinase without rhabdomyolysis. In view of his symptomatic seroconversion and low baseline CD4+ T-lymphocyte count, the patient was treated promptly with combination antiretroviral therapy. Subsequently, he made good clinical improvement on treatment and no opportunistic infections were diagnosed at presentation or as part of a later immune reconstitution syndrome. This novel case highlights the importance of clinical suspicion of HIV and suggests that primary HIV-1 infection should be considered in patients presenting with severe hyperferritinaemia or markedly elevated creatine ki...
Genital ulcers: it is not always simplex ...
We report the first case of influenza B virus and adenovirus infections associated with this presentation. (Source: International Journal of STD and AIDS)
IJERPH, Vol. 11, Pages 12726-12738: Assessment of Sex-Related Behaviours, Human Immunodeficiency Virus (HIV) Knowledge and Sexually Transmitted Infections (STIs) among Men of Reproductive Age in Cameroon
Sexually transmitted infections (STIs), including human immunodeficiency virus (HIV), are among the major public health challenges in Cameroon. This paper determined the effect of men?s sex-related behaviors and HIV knowledge on reported STIs. The data came from the 2012 Cameroon?s Demographic and Health Survey (DHS) that were collected from 7191 respondents in 2012. Descriptive and logistic regression methods were used for data analysis. Results showed that majority of the respondents were aware of STIs and Acquired Immune Deficiency Syndrome (AIDS), while 3.96% reported STIs. Also, 49.45% of the men had no wife, while 75.58% and 84.58% noted that condoms and keeping of one partner could be used to prevent HIV transmission, respectively. Wrong impressions that mosquito bites and shari...
In silico analysis of autoimmune diseases and genetic relationships to vaccination against infectious diseases
Conclusions: Results showing unique and common gene sets, pathways, immune system categories and functional clusters of genes in four autoimmune diseases suggest it is possible to develop molecular classifications of autoimmune and inflammatory events. Combining this information with cellular and other disease responses should greatly aid in the assessment of potential immune-mediated adverse events following vaccination. (Source: BMC Immunology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
A concept in flux: questioning accountability in the context of global health cooperation
DiscussionAccountability is frequently reduced to one set of actors holding another to account. Changes in the global health landscape and in relations between actors have however made the practice of accountability more complex and contested. Currently undergoing a reframing process, participation and transparency have become core elements of a new accountability agenda alongside evaluation and redress or enforcement mechanisms. However, while accountability is about holding actors responsible for their actions, the mechanisms through which this might be done vary substantially and are far from politically neutral.Accountability in global health cooperation involves multipolar relationships between a large number of stakeholders with varying degrees of power and influence, where not all i...
The changing pattern of ano-rectal cancer, squamous cell carcinoma of the eye, and Hodgkin¿s lymphoma as non-AIDS-defining cancers, by HIV status, in Tanzania over 11 years (2002-2012): a retrospective case-report study
Conclusions: The frequency and proportions of these three NADCs in Tanzania have increased over the past 11 years, as has the prevalence of HIV positivity amongst these NADC patients. The current and possibly increasing burden of NADCs in Tanzania and other low- and middle-income countries with high HIV rates should be a focus for future cancer prevention and control and HIV therapy programs. (Source: Infectious Agents and Cancer)
Practical aspects of setting up obstetric skills laboratories - A literature review and proposed model.
CONCLUSIONS AND IMPLICATIONS FOR PRACTICE: obstetric skills laboratories can play a substantial role in increasing competency and confidence of staff via 'skills and drills' type training. When considering setting up skills laboratories, this can be simply done using low fidelity manikins in the first instance with training facilitated by motivated trainers using realistic clinical scenarios. Overall, the review findings highlight the need for better documentation of factors that promote and/or are barriers to the effective use of skills laboratories. SYNOPSIS: 31 papers detailing the planning and organisation of skills laboratories were reviewed in order to assess the factors necessary for their effectiveness and the vital role they play in increasing staff competencies. Setting up ob...
It's Time to Allow Gay Men to Donate Blood
Gay men face obstacles to donating blood in more than 50 countries, including Brazil. It's time to change that. About 50 countries preclude gay men from donating blood, regardless of their health at the time of donation and their sexual habits, according to a report published by El País. Even countries with advanced views on the issue of gay rights, such as Germany, France, the Netherlands and Denmark, among others, bar gays from donating blood. The United States and Israel are also on the list. On the other hand, Russia, a notoriously homophobic country with a law prohibiting "distribution of homosexual propaganda," does not impose restrictions on blood donation by gay men, and neither do Chile, Spain, Italy, Mexico, Poland, Portugal or South Africa, according to El País' survey. In...
Developing a Decision Aid to Support Informed Choices for Newly Diagnosed Patients With Localized Prostate Cancer
Conclusions:We developed a Spanish DA with a strong quality score to help patients make an informed choice regarding their prostate cancer treatment. Future research will assess the impact of the DA and its association with improved decision making. Implications for Practice:This tool provides information about the risks and benefits of different treatment options and helps patients to understand the importance of their own values for informing treatment choices. (Source: Cancer Nursing)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Association of Chronic HCV With T-Cell Phenotypes in HIVAssociation of Chronic HCV With T-Cell Phenotypes in HIV
How does HIV status affect HCV viremia? JAIDS: Journal of Acquired Immune Deficiency Syndromes (Source: Medscape Today Headlines)
ART for Prevention of Mother-to-Child TransmissionART for Prevention of Mother-to-Child Transmission
ART is recommended to HIV+ women for prevention of perinatal transmission of HIV. Are these women at risk of resistance after stopping the ART regimen? AIDS (Source: Medscape PublicHealth Headlines)
Food Insecurity and Its Relation to Psychological Well-Being Among South Indian People Living with HIV
Abstract Food insecurity (FI) and its link with depression and quality of life (QOL) among people living with HIV (PLHIV) in India are not well-documented. We analyzed cohort data from 243 male and 129 female PLHIV from Bengaluru, and found 19 % of men and 26 % of women reported moderate or severe FI over a 6-month period. Women reported higher mean depression than men, and lower mean QOL. In multivariate analyses adjusting for HIV stigma and demographic covariates, both male and female PLHIV with moderate to severe FI showed lower mean QOL than those reporting mild to no FI. Male but not female food insecure participants also had higher depression scores in adjusted regression analyses. As ART has improved the physical health of PLHIV, more effort is being invested in improvin...
Sexual Behavior and Risk Practices of HIV Positive and HIV Negative Rwandan Women
We describe factors influencing current sexual practices of Rwandan women living with or without HIV/AIDS. By design, 75 % of participants were HIV positive and ~50 % reported having experienced genocidal rape. Univariate and multivariate logistic regression models were fit to describe demographic and clinical characteristics that influenced sexual behavior in the previous 6 months, condom use, history of transactional sex, and prior infection with a non-HIV sexually transmitted disease. Respondents? age, where they lived, whether or not they lived with a husband or partner, experience of sexual trauma, CD4 count, CES-D and PTSD scores were strongly associated with risky sexual behavior and infection with non-HIV STI. HIV positive women with a history of sexual violence in the context...
Communication About Microbicide Use Between Couples in KwaZulu-Natal, South Africa
Abstract The ways in which couples communicate about microbicides is likely to influence microbicide uptake and usage. We collected quantitative data about whether women in a microbicide trial discussed microbicides with their partners and explored communication about microbicides during 79 in-depth-interviews with women enrolled in the trial and 17 focus-group discussions with community members. After 4 weeks in the trial, 60 % of 1092 women had discussed microbicides with their partners; in multivariate analysis, this was associated with younger age, clinic of enrolment and not living in households that owned cattle. After 52 weeks, 84 % of women had discussed microbicides; in multivariate analysis, this was associated with not living in households that owned cattle, not liv...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Refined Software for Readers with Vision Disabilities
Two key refinements that improve the experience of people who are blind or have low vision who use iPads as touch-based reading devices have been developed by Francis Quek, Texas A&M professor of visualization, and Yasmine N. El-Glaly, assistant professor of computer science at Port Said University in Egypt. (Source: Disabled World)
Uganda: Steps Towards an HIV-Free Generation in Uganda
[Key Correspondents]Worldwide an increasing number of children who contracted HIV as babies are surviving into adolescence, even without medication, but many are dying before treatment can be initiated or be effective. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: HIV/Aids Spread Attributed to Gender Violence
[Daily Trust]Gender-based violence has been identified as a contributing factor to the spread of the HIV/AIDS in Nigeria. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: World Aids Day Statement 2014
[Commonwealth]Statement by: Commonwealth Secretary-General Kamalesh Sharma (Source: AllAfrica News: HIV-Aids and STDs)
Namibia: Veronica Kalambi Living a Positive Life With HIV
[New Era]Windhoek -"I have been living with HIV for 12 years now and to tell you the truth initially it was not easy for me," said Veronica Kalambi an HIV activist with the Namibia Women's Health Network (NWHN). (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Rwanda: HIV/Aids Fight: We Have a Long Way to Go
[New Times]The Rwanda Aids Indicator Survey (RAIS) has revealed that many Rwandans are still ignorant about basic information in the fight against HIV/Aids. (Source: AllAfrica News: HIV-Aids and STDs)
Zimbabwe: Mapeza Named Ambassador
[The Herald]FC Platinum coach Norman Mapeza has been appointed brand ambassador for the National Aids Council here. Speaking at World AIDS Day District commemorations at Mandava, Winston Chitando, the Mimosa executive chairman, announced to thousands of people that Mapeza was now carrying the torch. (Source: AllAfrica News: HIV-Aids and STDs)
Rwanda: First Lady Helps Raise Funds to Fight Aids
[New Times]Parents and communities need to care for the young and talk to children about HIV/Aids to prevent future generations from the scourge, the First Lady has urged. (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: An HIV Test Is Worth Your While
[The Star]It was World Aids Day on Monday, the first of December, and I had dinner on that night with a couple who have been together for decades. The lady was telling us about a guy who is suing his doctor for a false HIV positive that ended up costing him his family, his mental health and eventually his job. It took years for him to get another test that showed he was never HIV positive, but by then his wife had left him and taken the kids with her. This led to a conversation about HIV and Aids and how it doesn't (Source: AllAfrica News: HIV-Aids and STDs)
Ethiopia: Building On Our HIV/Aids Successes in Ethiopia
[Reporter]On World AIDS Day, commemorated on December 1 every year, we pay tribute to the millions who are infected and affected by HIV/AIDS worldwide. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Kenya: More Education Is Needed On HIV-Aids
[The Star]There was a point in time when being HIV positive was considered a death sentence and not just for the patient, but anyone who dared to associate with the infected. The level of stigma surrounding HIV-Aids was so high that no one even dared shake hands with a HIV-positive person. Back then, some people believed the disease was spread through handshakes. If a man lost too much weight within a relatively short time, he had HIV; if a man left his wife she had HIV; if someone was taking more than two pills, th (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: Taraba Emerges Second HIV/Aids Ravaged State
[Guardian]THE continued rise in the prevalence rate of HIV/AIDS in Taraba State, pegged at 10.5 per cent, has placed the state in the position of the second most HIV/AIDS ravaged state in the country. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: Hope for Those Living With HIV and Killer Parasitic Disease
[Key Correspondents]The search for new treatment for patients co-infected with HIV and kala-azar is in its early stages, but researchers are certain a drug to treat the condition could be found in 2015. (Source: AllAfrica News: HIV-Aids and STDs)
Namibia: 20 Years and Still Counting - Aids Activist Recounts Struggles
[Namibian]FIFTY-FIVE-YEAR-OLD Anita Isaacks was diagnosed with full-blown AIDS about 12 years ago, and has been living with the virus for the past 20 years. (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: Busia Unveils Plans to Fight HIV and Stigma
[The Star]BUSIA county has unveiled a plan to eliminate stigmatisation and discrimination of teachers living with HIV-Aids. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
South Africa: Cosatu Northern Cape Statement On the Mortality Statistics
[COSATU]The Congress of South African Trade Unions in the Northern Cape is deeply shocked to learn that HIV/AIDS is the leading cause of death in our province at 8.7%. These shocking statistics emerge against the backdrop of the celebration of the World AIDS Day which was celebrated in John Taolo Gaetsewe region on 01 December 2014. (Source: AllAfrica News: HIV-Aids and STDs)
Zambia: World Aids Day - Focus On Adolescents
[Times of Zambia]On World AIDS Day, I received the following message from the International Aids Alliance (IAA): This World AIDS Day (December 1, 2014) we are warning of the urgent need to prioritise HIV and sexual and reproductive health services for adolescents, particularly in the global south where they are slipping through the cracks when it comes to healthcare. (Source: AllAfrica News: HIV-Aids and STDs)
Rwanda: First Lady Calls for Innovation in Aids Fight
[New Times]The First Lady, Jeannette Kagame, has called for innovation in the fight against HIV/Aids as an additional mechanism in the prevention and treatment of the virus. (Source: AllAfrica News: HIV-Aids and STDs)
Ethiopia: Ethiopia Conducts Mass HIV Testing As Part of World Record Bid
[Ethiopia Government]To mark World AIDS Day this week, Ethiopia conducted a mass HIV testing campaign in an attempt to set a new world record for the most number of people HIV tested in single venue in an eight-hour period. Rahel Gettu, UNAIDS country community mobilisation and networking advisor in Ethiopia, said on Wednesday (December 3) that a total of 3,383 people had been tested for HIV status during the campaign held in Gambella Stadium. (Source: AllAfrica News: HIV-Aids and STDs)
Rwanda: More Sensitisation Needed in HIV/Aids Fight - survey
[New Times]At least 32 per cent of Rwandans still believe HIV/Aids can be transmitted through mosquito bites, according to the Rwanda Aids Indicator Survey (RAIS) report. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Eritrea: Low Prevalence of HIV/Aids Expressed Indication for Growing Awareness of the Public
[Shabait]Barentu -At a meeting the members of Bidiho National Association in Gash Barka region conducted, they expressed that the low prevalence of HIV/AIDS is an indication of the growing awareness of the public. (Source: AllAfrica News: Health and Medicine)
How A New Funding Model Will Shift Allocations From The Global Fund To Fight AIDS, Tuberculosis, And Malaria [Web First]
We examined the Global Fund&rsquo;s historical HIV allocations and its predicted allocations under a new funding model that creates an explicit allocation methodology. We found that under the new funding model, substantial shifts in the Global Fund&rsquo;s portfolio are likely to result from concentrating resources in countries with more HIV cases and lower per capita incomes. For example, South Africa, which had 15.8&nbsp;percent of global HIV cases in 2009, could see its Global Fund HIV funding more than triple, from historic levels that averaged 3.0&nbsp;percent to 9.7&nbsp;percent of total Global Fund allocations. The new funding model methodology is expected, but not guaranteed, to improve the efficiency of Global Fund allocations in comparison to historical practice. We conclude with...
Probe-based confocal laser endomicroscopy in the pancreatic duct provides direct visualization of ductal structures and aids in clinical management
Confocal endomicroscopy provides real-time evaluation of various sites and has been used to provide detailed endomicroscopic imaging of the biliary tree. We aimed to evaluate the feasibility and utility of probe-based confocal laser endomicroscopy of the pancreatic duct as compared to cytologic and histologic results in patients with indeterminate pancreatic duct strictures. (Source: Digestive and Liver Disease)
Perspectives of linkage to care among people diagnosed with HIV
Timely linkage to HIV care and treatment has led to improved individual and population benefits; however, 25%-31% of people diagnosed with HIV do not engage in care. Most linkage to care research has focused on larger metropolitan areas, but smaller metropolitan and rural areas encounter unique challenges to linkage to care. Our purpose was to examine factors influencing the decision to seek care by 27 people infected with HIV living in smaller metropolitan and rural areas of Florida. We used grounded theory methods to develop a theoretical model describing the decision-making process and participant recommendations within the context of stigma. (Source: Journal of the Association of Nurses in AIDS Care)
Death from AIDS is preventable, so why are people still dying of AIDS in Europe?
Authors: Delpech V, Lundgren J PMID: 25443033 [PubMed - in process] (Source: Euro Surveill)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Call Center Technology for Employees with Vision Disability
Optimized to work with Job Access With Speech (JAWS) assistive technology, Platform 3 VocalVision enables call center agents with vision disabilities to effectively navigate Platform 3.0, TCN?s cloud-based contact center suite, helping to improve agent productivity while also creating new employment opportunities for people with vision disabilities. (Source: Disabled World)
Angola: Health Officials Concerned About New HIV/Aids Cases in Namibe
[ANGOP]Namibe -Health officials in the south-west Namibe province have expressed concern about the new cases of HIV/ AIDS reported from January to November this year. (Source: AllAfrica News: HIV-Aids and STDs)
Assessment of Prevalence and Determinants of Occupational Exposure to HIV Infection among Healthcare Workers in Selected Health Institutions in Debre Berhan Town, North Shoa Zone, Amhara Region, Ethiopia, 2014.
Conclusion. In this study majority (88.6%) of the health care workers had a risky occupational hazard that exposed them to human immunodeficiency virus infection during the past 12 months. The statistically significant determinant factors were professional status, working room, and time of personal protective equipment usage. PMID: 25478213 [PubMed - as supplied by publisher] (Source: AIDS Research and Treatment)
Evaluation of the Effectiveness of Peer Education in Improving HIV Knowledge, Attitude, and Sexual Behaviours among In-School Adolescents in Osun State, Nigeria.
Conclusion. The study showed that peer education is effective in improving knowledge, attitude, and some preventive practices towards HIV/AIDS among in-school adolescents. Educational programmes about HIV/AIDS should therefore be designed to target this age group putting into consideration their unique characteristics. PMID: 25478212 [PubMed - as supplied by publisher] (Source: AIDS Research and Treatment)
MicroRNA-34a regulates WNT/TCF7 signaling and inhibits bone metastasis in Ras-activated prostate cancer.
Authors: Chen WY, Liu SY, Chang YS, Yin JJ, Yeh HL, Mouhieddine TH, Hadadeh O, Abou-Kheir W, Liu YN Abstract Aberrant activation of Ras and WNT signaling are key events that have been shown to be up-regulated in prostate cancer that has metastasized to the bone. However, the regulatory mechanism of combinatorial Ras and WNT signaling in advanced prostate cancer is still unclear. TCF7, a WNT signaling-related gene, has been implicated as a critical factor in bone metastasis, and here we show that TCF7 is a direct target of miR-34a. In samples of prostate cancer patients, miR-34a levels are inversely correlated with TCF7 expression and a WNT dependent gene signature. Ectopic miR-34a expression inhibited bone metastasis and reduced cancer cell proliferation in a Ras-dependent xenograf...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
A review of drug policy in the Golden Crescent: Towards the development of more effective solutions.
Authors: Talpur A, George TP Abstract There is a high prevalence of drug trafficking and misuse in Asia. Drugs grown in Afghanistan are trafficked through Iran and Pakistan to the rest of the world. This has led to an increase in the prevalence of drug use disorders in these regions, especially heroin. This has in turn led to an increase in the use of syringes and syringe sharing which has resulted in the exponential spread of blood borne diseases such as HIV/AIDS. A lack of awareness of the detrimental use of heroin, syringe sharing and the concept of HIV has been revealed. The literature reviewed provides evidence for a change in policy with an increase in epidemiological and clinical research in these regions as well as an increase in public awareness. PMID: 25440559 [PubMed...
Chronic Postoperative Pain After Primary and Revision Total Knee Arthroplasty
This study aimed to investigate the difference in pain, mobility, and quality of life (QoL) in patients after revision TKA compared with patients after primary TKA. Methods:A total of 99 OA patients after revision TKA surgery and 215 patients after primary TKA surgery were investigated in a cross-sectional study using: a pain description of current pain (non-existent, mild, moderate, severe, or unbearable), the pain intensity visual analogue scale, the Knee Society Score, and the Osteoarthritis Research Society International questionnaire. Results:Nineteen percent after primary TKA surgery and 47% after revision TKA surgery experienced severe to unbearable chronic postoperative pain. After revision TKA surgery patients reported higher pain intensities during rest (P=0.039), while walking (...
Experiences and Correlates of HIV Self-Testing Among Men Who Have Sex with Men in Jiangsu Province, China
We describe experiences and identify correlates of self-testing among Chinese MSM. A cross-sectional survey was conducted among MSM in Jiangsu from November 2013 to January 2014. Participants were recruited through time-location sampling and from online. Participants were asked a series of questions about HIV self-testing uptake and associated experiences. Logistic regression was used to identify correlates of having ever self-tested for HIV. Of 522 participants, 26.2 % had ever self-tested. Finger stick was the most common self-testing modality (86.1 %). A majority of participants reported that it was ?very easy? (43.1 %) or ?somewhat easy? (34.3 %) to perform self-testing while lower proportions reported ?very confident? (24.1 %) or ?somewhat confident? (36.5 %) in ...
Key Populations in Sub-Saharan Africa: Population Size Estimates and High Risk Behaviors
(Source: AIDS and Behavior)
Designing a System for Patients Controlling Providers? Access to their Electronic Health Records: Organizational and Technical Challenges
CONCLUSIONS Assessing patients? preferences for access to their EHRs and applying them in clinical practice requires wide-ranging technical, clinical, and bioethical expertise, to make tough choices to overcome significant technical and organization challenges. (Source: Journal of General Internal Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Provider Responses to Patients Controlling Access to their Electronic Health Records: A Prospective Cohort Study in Primary Care
CONCLUSIONS Patients frequently preferred restricting provider access to their EHRs. Providers infrequently overrode patients? preferences to view hidden data. Providers believed that restricting EHR access would adversely impact patient care. Applying Fair Information Practice principles to EHRs will require balancing patient preferences, providers? needs, and health care quality. (Source: Journal of General Internal Medicine)
[Aniridia syndrome : Clinical findings, problematic courses and suggestions for optimization of care ("aniridia guide").]
We present a group of 130 patients with congenital aniridia to enhance awareness of the complexity of the disease. Different to other congenital visual impairments aniridia is characterized by many ocular complications arising during the lifetime which may lead to total blindness (e.g. cataract, aniridic keratopathy and secondary glaucoma). Furthermore, there is a specific surgical risk entity: aniridia fibrosis syndrome and anterior segment fibrosis syndrome (ASFS) which lead to a non-infectious fibrous scarring and membrane formation of the anterior segment, often followed by hypotonia and phthisis. Aniridic glaucoma presents yet another severe complication which is often diagnosed late due to diagnostic problems and which may lead to irreversible optic nerve damage. DISCUSSION: The ...
This Week In Science: Seeing Infrared, Earth's Shield, and a Bug Smorgasbord
Seven days; lots of science in the news. Here's our roundup of this week's most notable and quotable items: Illustration by Sarah Peavey The first test flight of the Orion capsule -- NASA's Apollo-like module designed to be the next thing in manned space exploration -- was beset by weather-related delays and glitches. Zig-zag marks scratched into a shell about 500,000 years ago, likely by a member of Homo erectus, may be the earliest example of hominid carving. You can probably see infrared light, to some degree. Geckos still stick to surfaces after they die. Playing just a single season of high school football was found to cause changes in the brain -- more so in heavy hitters -- even if kids don't suffer concussions. The 3D printer on the International Space Station spat out its firs...
HIV and Ebola: similarities and differences.
Authors: Wainberg MA, Kippax S, Bras M, Sow PS PMID: 25466882 [PubMed - in process] (Source: Journal of the International AIDS Society)
Africa: Most Africans Happy With Govt Action on Aids
[Afrobarometer]Most Africans say their governments are doing a good job in the fight against HIV/AIDS, a new Afrobarometer analysis shows. (Source: AllAfrica News: Health and Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Nigeria: FUTO Renews Battle Against HIV/Aids
[Independent (Lagos)]Owerri -Worried by the increasing cases of HIV/aids syndrome, the Centre for Women, Gender and Development Studies (CWGDS), Federal University of Technology, Owerri (FUTO), has indicated its intention to partner the youths to reduce incidence of HIV infections and discrimination against HIV patients. (Source: AllAfrica News: HIV-Aids and STDs)
Tanzania: Moshi Residents Shun Aids Scare - Claim
[Daily News]Moshi -Moshi residents are typically laissez-faire when it comes to HIV/AIDS matters as many are unresponsive to voluntary testing and Counselling (VCT) services, soothing themselves with data that show HIV prevalence declined from 2.3% last year to 2.1% September this year. (Source: AllAfrica News: HIV-Aids and STDs)
[Correspondence] Appeal to global donors to save the Treatment Action Campaign
Fulfilling the right to health depends on common purpose between researchers, clinicians, and activists. On the eve of World AIDS Day 2014 (Dec 1), we write this letter as scientists and academics who are concerned about the possible closure of the Treatment Action Campaign (TAC) in South Africa as a consequence of serious funding difficulties. (Source: LANCET)
[Comment] NCDs and an outcome-based approach to global health
A decade ago, HIV/AIDS transformed global health. The epidemic affected wealthy nations first, but did most of its damage in low-income and middle-income countries, where HIV/AIDS caused large numbers of premature adult deaths and shook governments. The international community responded by developing life-saving treatments and expanding their availability in poorer countries. That global response saved millions of lives and encouraged international support to address other public health challenges, including malaria, family planning, and maternal and child health. (Source: LANCET)
Namibia: Stigma a Hurdle in HIV-Aids Mitigation Efforts
[New Era]Windhoek -The only way to reduce HIV infections is when people stop discriminating against those who are infected with the incurable virus, activists said yesterday. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
South Africa: Grassroot Soccer - Moving the Goalposts in the Fight Against HIV/Aids
[Daily Maverick]This week, HIV/Aids has undoubtedly received more media attention than it ordinarily would have. But for the men and women working at Grassroot Soccer, World Aids Day is not much different to any other: it is simply one of the 365 they spend per year, fighting the disease through a language most of us speak - sport. (Source: AllAfrica News: HIV-Aids and STDs)
Zambia: Nac Decries Low Condom Use
[Times of Zambia]THE National AIDS Council (NAC) has bemoaned the low condom use by women compared to their male counterparts. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: The Downside of Improved HIV Care
[SciDev.Net]"We have bent the trajectory of the epidemic. Now we have five years to break it for good or risk it rebounding out of control," said UNAIDS executive director Michel Sidibé last month as the agency announced plans to increase antiretroviral drug availability. [1] (Source: AllAfrica News: HIV-Aids and STDs)
Uganda: Fake HIV Results Trial Starts
[Observer]Court in Mukono has started hearing the case where a woman is facing charges of negligence and bribery, after she allegedly falsified HIV results of an undercover intending 'bride'. (Source: AllAfrica News: HIV-Aids and STDs)
Eritrea: Call Made for Stepped-Up Efforts Towards Combating New HIV Infection
[Shabait]Barentu -A call has been made for exerting stepped-up efforts towards combating new HIV infection and reducing its consequences on the basis of highly organized promotional activities. The call was made in connection with the commemoration of World AIDS Day in Barenru town at national level. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Ethiopia: First IGAD International Scientific Conference Opened in Addis Ababa
[Ethiopia Government]Dr. Kesete-Berhan Admasu, Ethiopia's Minister of Health, and Engineer Mahboub Maalim, the Executive Secretary of IGAD, officially opened the first IGAD International Scientific Conference on Health with special emphasis on pastoralists and cross-border mobile populations. (Source: AllAfrica News: HIV-Aids and STDs)
Uganda: Outcry Over Museveni's Aids Remarks
[Independent (Kampala)]Civil Society activists against HIV/AIDS have demanded an apology from President Yoweri Museveni over some of the remarks he made during the commemoration of World AIDS Day in Fort Portal on Dec.1. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: Ondo, Global Help Move to Prevent HIV/Aids Transmission
[Independent (Lagos)]In continuation of the fight against HIV/AIDS and arrest of the spread of the disease, the Ondo State government, through the Ondo State Agency for the Control of AIDS (ODSACA), in collaboration with Global Help Trust Foundation (gloHELP), a non-governmental organisation, has carried out a minimum prevention session among pregnant women in the state, to bring an end to mother-to-child transmission of HIV/AIDS. (Source: AllAfrica News: HIV-Aids and STDs)
Global Fund investments in human resources for health: innovation and missed opportunities for health systems strengthening
Conclusion The narrow disease focus and lack of co-ordination with national governments call into question the efficiency of funding and sustainability of Global Fund investments in HRH and their effectiveness in strengthening recipient countries&rsquo; health systems. The lessons that emerge from this analysis can be used by both the Global Fund and other donors to improve co-ordination of investments and the effectiveness of programmes in recipient countries. (Source: Health Policy and Planning)
Development of a patient?centred, patient?reported outcome measure (PROM) for post?stroke cognitive rehabilitation: qualitative interviews with stroke survivors to inform design and content
ConclusionsThe results support the development of a PROM specifically designed to address the impact of cognitive problems. It should: include items addressing a comprehensive range of cognitive skills; ask questions about mood, self?identity and social participation; use accessible wording that respondents understand and endorse; measure impact rather than frequency; and explore perceived impact on carers. (Source: Health Expectations)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Comparative study of lithium bis(oxalato)borate and lithium bis(fluorosulfonyl)imide on lithium manganese oxide spinel lithium-ion batteries
Publication date: 5 March 2015 Source:Journal of Alloys and Compounds, Volume 624 Author(s): Renheng Wang , Xinhai Li , Zhixing Wang , Huajun Guo , Mingru Su , Tao Hou The comparative study of lithium bis(oxalato)borate (LiBOB) and lithium bis(fluorosulfonyl)imide (LiFSI) used as an additive in the performance of lithium manganese oxide spinel (LiMn2O4) cathode was systematically investigated at elevated temperature. The results indicated that a solid-electrolyte interphase (SEI) film on cathode produced by the oxidation of the LiFSI additive is more robust and stable against Mn dissolution problem during cycling at 55°C compared with the SEI formed by the oxidation of the Blank and the LiBOB-added electrolyte. LiFSI aids in stabilizing the electrolyte by trapping the PF5, i.e., sequest...
AIDSinfo Releases Drug App for iOS and Android Devices
AIDSinfo is pleased to announce the release of the AIDSinfo Drug App. Using data from the AIDSinfo Drug Database, the drug app provides information on more than 100 HIV-related approved and investigational drugs. The information, offered in English and Spanish, is tailored to meet the needs of both health care providers and consumers. The app is designed to automatically refresh when the user is connected to a wireless or cellular data network. The auto update feature eliminates the need to manually update the app to view the most current drug information. In addition, the app works offline, ensuring that health care providers and consumers can access vital drug information anywhere&mdash;even in health care facilities that may not have an Internet connection. &nbsp; Health care providers ...
Recent HIV/AIDS News
December 1, 2014: From NIH: Sophisticated HIV Diagnostics Adapted for Remote Areas November 25, 2014: From CDC: Only 3 in 10 Americans with HIV Have Virus in Check November 24, 2014: From NIAID: Starting Treatment Soon After HIV Infection Improves Immune Health, Study Finds (Source: AIDSinfo At-a-Glance: Offering Information on HIV/AIDS Treatment, Prevention, and Research, A Service of the U.S. Department of Health and Human Services (DHHS))
Ebola ? the best and the worst within nursing?and maybe us all
?Epidemics bring out the worst and the best elements of humanity? ? a remark made by a Royal College of Nursing colleague of mine in 1988. He was, of course, referring to HIV/AIDS as we were then in the midst of HIV?s emergence within Europe. At that time the panic and anxiety was palpable, the media was full of hysteria and misinformation and this was also having an effect on the nursing and medical profession. Refusals to care for people with AIDS were common and the stigmatisation of people with HIV was widespread. (Source: Nursing Outlook)
Spontaneous control of HIV-1 viremia in a subject with protective HLA-B plus HLA-C alleles and HLA-C associated single nucleotide polymorphisms
Conclusions: CASE1 has controlled her HIV-1 viremia below the limit of detection in the absence of antiretroviral therapy for more than 14?years and has not shown any sign of immunologic deterioration or disease progression. Co-expression of multiple protective HLA alleles, HLA-C SNPs and strong T cell responses against HIV-1 proteins are the most likely explanation of this very benign case of spontaneous control of HIV-1 disease progression. (Source: Journal of Translational Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
The influence of different hydroponic conditions on thorium uptake by Brassica juncea var. foliosa.
Authors: Wang D, Zhou S, Liu L, Du L, Wang J, Huang Z, Ma L, Ding S, Zhang D, Wang R, Jin Y, Xia C Abstract The effects of different hydroponic conditions (such as concentration of thorium (Th), pH, carbonate, phosphate, organic acids, and cations) on thorium uptake by Brassica juncea var. foliosa were evaluated. The results showed that acidic cultivation solutions enhanced thorium accumulation in the plants. Phosphate and carbonate inhibited thorium accumulation in plants, possibly due to the formation of Th(HPO4)(2+), Th(HPO4)2, or Th(OH)3CO3 (-) with Th(4+), which was disadvantageous for thorium uptake in the plants. Organic aids (citric acid, oxalic acid, lactic acid) inhibited thorium accumulation in roots and increased thorium content in the shoots, which suggested that the t...
Nigeria: Nigerian Gov't Urged to Close PMTCT Gaps
[Independent (Lagos)]The government of Nigeria has been asked to allocate adequate resources into Prevention of Mother-To-Child transmission of HIV (PTMCT) and maternal health care prevent more women and children from dying. (Source: AllAfrica News: HIV-Aids and STDs)
South Africa: Getting to Zero - Commemorating World Aids Day 2014
[U.S. Embassy Pretoria]Getting to Zero: Focus, Partner and Achieve towards an AIDS-free Generation was the theme of this year's World Aids Day commemoration at the United States Embassy in Pretoria on December 2. (Source: AllAfrica News: Health and Medicine)
Nigeria: FG Revises Workplace Policy on HIV/Aids
[Daily Trust]The federal government has reiterated its commitment to upholding the rights and dignity of all Nigerian workers, irrespective of their HIV/AIDS status, pledging to end stigmatisation and discrimination against infected workers. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: 'Over 700,000 Infected With HIV/Aids Annually'
[Daily Trust]Nigeria records over 700,000 HIV/AIDS cases annually, Chairman, House of Representatives Committee on HIV/AIDS, Malaria, Tuberculosis and Leprosy, Dr. Joseph Haruna Kigbu, said yesterday. (Source: AllAfrica News: Health and Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Africa: Global Fund Will Need to Re-Allocate U.S.$1.3 Billion in Resources by End-2017
[GFO]The Global Fund will need to re-allocate an estimated $1.3 billion to ensure continuity of services through 2017, due to the decision to allow some countries to shorten the length of grants approved under the new funding model - assets that will likely be found from other countries' inability to absorb all of the funds they've been allocated. (Source: AllAfrica News: HIV-Aids and STDs)
South Africa: HIV Patients Miss Out On Crucial Test
[Health-e]One test may mean the difference between life and death for people with HIV on antiretroviral (ARV) treatment, but the Treatment Action Campaign (TAC) says many patients are not getting viral load testing. (Source: AllAfrica News: HIV-Aids and STDs)
South Africa: Treatment Action Campaign Pickets Mpumalanga Clinic
[Health-e]To mark World AIDS Day, the Treatment Action Campaign's (TAC) Mpumalanga branch picketed outside a local clinic as the AIDS lobby continues to complain about poor service delivery. (Source: AllAfrica News: HIV-Aids and STDs)
South Africa: Guide - HIV in Our Lives
[Health-e]In the latest updated version of its well known HIV treatment literacy guide, the Treatment Action Campaign explains the science behind HIV. (Source: AllAfrica News: HIV-Aids and STDs)
Botswana: Workplace Policies for HIV-Aids Critical
[Botswana Daily News]Selibe Phikwe -Batswana have been urged to go for voluntary counseling and testing to know their HIV status and lead a positive lifestyle. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Kenya: Youth Want Law On HIV Medicine
[The Star]The Youth in Uasin Gishu county yesterday urged the government to make laws that will guide the use of contraceptives. (Source: AllAfrica News: HIV-Aids and STDs)
New Designated AIDS Center director ready to help state end AIDS epidemic
New York wants to decrease new HIV infections to 750 from 3,000. Reddy says more outreach and significant increases in HIV testing can put the goal within reach. (Source: SUNY Upstate Medical)
Tanzania: Demystifying HIV/Aids Key to Winning War Against Pandemic
[Daily News]TANZANIA this week joined the rest of the world in marking the World Aids Day where humanity got the chance to remember those who succumbed to the disease, while at the same time looking at successes and failures in trying to mitigate the social anomaly. (Source: AllAfrica News: HIV-Aids and STDs)
Botswana: Botswana Fails Guiness World Record
[Botswana Daily News]Maun -Botswana has failed to reach the set target of testing 6 000 people for HIV in eight hours to beat the Guinness World Record of "Most HIV Tests Given in One City in Multiple Venues in 8 hours in One Day." (Source: AllAfrica News: HIV-Aids and STDs)
How can we better identify early HIV infections?
We describe markers of EHI, diagnostic strategies for detecting these markers, and ways to incorporate these strategies into diagnostic and HIV incidence algorithms. Recent findings: For individual diagnosis in the USA and Europe, laboratory-based diagnostic algorithms increasingly incorporate fourth-generation HIV antigen tests, allowing for earlier detection. In some sub-Saharan African settings, symptom-based screening is being explored to identify subsets of persons at high risk for AHI. Point-of-care diagnostics designed for AHI detection are in the pipeline and, if validated, represent an opportunity for real-time AHI diagnosis. At the population level, multiassay algorithms are promising new strategies for estimating HIV incidence on the basis of several assays applied to cross-sect...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Implementing early diagnosis and treatment: programmatic considerations
Purpose of review: To benefit very early treatment for an HIV cure, HIV infection must be diagnosed immediately after infection. We review potential strategies for expansion of HIV testing in preparation for a potential HIV cure in the distant future. Recent findings: Very early antiretroviral therapy (ART) initiated during acute or early HIV infection may result in long-term viral control. Such strategies will require programmatic systems for very early diagnosis and very early ART. Yet, most HIV-infected individuals start treatment late and presumably are diagnosed late. Operational issues will have to address the treatment cascade much earlier starting from HIV testing, test result notification, posttest counseling, immunological and clinical assessment and ultimately starting treatment...
Review: influence of ART on HIV genetics
Purpose of review: HIV genetic diversity poses major challenges for the prevention, control, and cure of infection. Characterizing the diversity and evolution of HIV populations within the host provides insights into the mechanisms of HIV persistence during antiretroviral therapy (ART). This review describes the HIV diversity within patients, how it is affected by suppressive ART, and makes a case for early treatment after HIV infection. Recent findings: HIV evolution is effectively halted by ART. However, cells that were infected prior to initiating therapy can proliferate to very high numbers both before and during treatment. Such clonal expansions result in the persistence of integrated proviruses despite therapy. These expanding proviruses have been shown to be a source for residual vi...
Preserving HIV-specific T cell responses: does timing of antiretroviral therapy help?
Purpose of review: HIV-specific T cell responses are likely to have an important role in HIV cure strategies that aim for long-lasting viral control without antiretroviral therapy (ART). An important issue in enhancing virus-specific T cell responses is whether timing of ART can influence their magnitude and breadth. Recent findings: Early ART is associated with lower T cell activation, preservation of T cell numbers, smaller DNA and RNA reservoir size, and, in a single study (VISCONTI), control of plasma viremia after treatment interruption. The prevention of T cell destruction by early ART is associated with relatively low anti-HIV CD8+ T cell responses but stronger CD4+ T helper function. The relatively lower CD8+T cell response, which is presumably due to rapid lowering of HIV antigen ...
Posttreatment controllers: what do they tell us?
Purpose of review: The posttreatment controllers (PTCs), as described for the Viro-Immunological Sustained COntrol after Treatment Interruption patients, are able to maintain durable HIV control after interruption of early antiretroviral therapy (ART). They are different from spontaneous HIV controllers who achieve HIV control without prior ART. PTCs provide proof-of-concept that prolonged ART-free remission is possible. Recent findings: PTCs support the idea that early treatment could be especially beneficial. They show that a stable equilibrium between a small HIV reservoir and HIV-1-specific immune responses can be achieved. PTCs occur at a frequency of 5 and 15% of patients with early combination ART interruption, which might be considered too infrequent to support early combination AR...
Impact of antiretroviral therapy (ART) timing on chronic immune activation/inflammation and end-organ damage
Purpose of review: The purpose of this review was to summarize recent studies on the effect of early antiretroviral therapy (ART) in HIV-infected patients on markers of immune activation/inflammation, viral persistence and serious non-AIDS events. Recent findings: Early ART, initiated within days to months of HIV infection, was associated with marked reduction in T-cell activation often reaching levels observed in HIV-uninfected individuals. However, the impact of early ART on markers of innate immune activation, microbial translocation and inflammation/coagulation was less clear. Early ART has also been associated with a significant reduction in the frequency of latently infected cells, which was greater if ART was initiated within days to weeks rather than months following infection. How...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Changes in HIV reservoirs during long-term antiretroviral therapy
Purpose of review: To review current knowledge about the impact of long-term combination antiretroviral therapy (cART) on HIV reservoirs. Recent findings: The number of HIV-infected cells that persist during long-term antiretroviral therapy is associated with the stage of HIV infection at the time of treatment initiation. Initiation of cART reduces the number of infected cells over the first 4 years of therapy, but thereafter there is no further decline despite long-term effective cART. The remarkable stability of infected cell numbers is likely due to a balance among homeostatic or antigen-driven proliferation of infected memory T-cells subsets, clonal expansion of a subset of infected cells as a consequence of specific retroviral integration sites, and death of other infected cells. At p...
Impact of earlier combination antiretroviral therapy on outcomes in children
Purpose of review: Early initiation of combination antiretroviral therapy (ART) in infants below 12 weeks of age reduces morbidity and mortality. A recent report of transient HIV remission in a child beginning ART from the second day of life has focused attention on very early therapy in the first days of life. Recent findings: In the randomized children with HIV, early antiretroviral limited ART beginning at a median of 7.4 weeks of age lowered mortality and disease progression significantly compared with deferred ART beginning at a median of 21 weeks on study. In high-burden settings, infants initiating ART appear sicker than in children with HIV early antiretroviral and start at a later age. Many could be diagnosed on the first day of life. There are still programmatic obstacles to earl...
How does the timing of antiretroviral therapy initiation in acute infection affect HIV reservoirs?
Purpose of review: The long-lived viral reservoir is a major obstacle to achieving a cure for HIV. Therapeutic strategies, such as early antiretroviral therapy (ART), may be a prerequisite to achieving long-term control of viral replication upon ART withdrawal. Recent findings: HIV persistence is established early in acute HIV infection (AHI) with infection in long-lived memory CD4+ T cells. Studies conducted in nonhuman primates have suggested that this could occur as early as 3 days postinfection; however, the timing in humans is uncertain. ART during AHI significantly restricts the HIV reservoirs as compared with later treatment. Early ART, particularly prior to the detection of HIV immunoglobulin M, may also reduce the contribution of the long-lived central memory CD4+ T cells to the t...
Editorial introductions
No abstract available (Source: Current Opinion in HIV and AIDS)
A cure for HIV: what will it take?
No abstract available (Source: Current Opinion in HIV and AIDS)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Very early combination antiretroviral therapy in infants: prospects for cure
This article covers the rationale and feasibility of VET to achieve sustained virologic remission in perinatal infection. Recent studies highlighting the effects of VET on biomarkers of HIV persistence in perinatal HIV infection are reviewed as well as implications and challenges for cure research in pediatric populations. (Source: Current Opinion in HIV and AIDS)
Rwanda: Woes of Living With HIV As a Woman
[New Times]World Aids Day is marked globally on December 1. This is a day that brings bad memories for many women living with HIV/Aids. For many it reminds them of the agony and pain they went through after contracting HIV at the hands of their unfaithful spouses or rape during the 1994 Genocide against the Tutsi. That is the story 36-year-old Daphrose Mushimiyimana relates to with deep pain. (Source: AllAfrica News: HIV-Aids and STDs)
People with mental illness more likely to be tested for HIV, Penn Medicine study finds
(University of Pennsylvania School of Medicine) People with mental illness are more likely to have been tested for HIV than those without mental illness, according to a new study from a team of researchers at Penn Medicine and the US Centers for Disease Control and Prevention published online this week in AIDS Patient Care and STDs. (Source: EurekAlert! - Infectious and Emerging Diseases)
Enhancing the Benefits of Antiretroviral Therapy in Vietnam: Towards Ending AIDS
Abstract Vietnam has a concentrated HIV epidemic, with the highest HIV prevalence being observed among people who inject drugs (PWID). Based on its experience scaling-up robust HIV interventions, Vietnam aims to further strengthen its response by harnessing the preventive benefits of antiretroviral therapy (ART). Mathematical modelling suggests that prioritizing key populations for earlier access to ART, combined with other prevention interventions, may have significant impact on the epidemic, cost-effectively reducing new HIV infections and deaths. Pilot studies are being conducted to assess feasibility and acceptability of expansion of HIV testing and counselling (HTC) and early ART among key populations and to demonstrate innovative service delivery models to address challenges...
AIDS: transforming global health
Publication date: 29 November?5 December 2014 Source:The Lancet, Volume 384, Issue 9958 Author(s): Robin Gorna (Source: The Lancet)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Ritonavir-boosted darunavir combined with raltegravir or tenofovir?emtricitabine in antiretroviral-naive adults infected with HIV-1: 96 week results from the NEAT001/ANRS143 randomised non-inferiority trial
Publication date: 29 November?5 December 2014 Source:The Lancet, Volume 384, Issue 9958 Author(s): François Raffi , Abdel G Babiker , Laura Richert , Jean-Michel Molina , Elizabeth C George , Andrea Antinori , Jose R Arribas , Jesper Grarup , Fleur Hudson , Christine Schwimmer , Juliette Saillard , Cédrick Wallet , Per O Jansson , Clotilde Allavena , Remko Van Leeuwen , Jean-François Delfraissy , Stefano Vella , Geneviève Chêne , Anton Pozniak Background Standard first-line antiretroviral therapy for HIV-1 infection includes two nucleoside or nucleotide reverse transcriptase inhibitors (NtRTIs), but these drugs have limitations. We assessed the 96 week efficacy and safety of an NtRTI-sparing regimen. Methods Between August, 2010, and September, 2011, we enrolled treatment-naive a...
FDA Advisors Not Sold on Lifting Ban on Gay Men Giving Blood
But American Red Cross, other groups urge easing restrictions due to better blood screening (Source: Fertility News - Doctors Lounge)
Risk factors associated with prevalent and incident syphilis among an HIV-infected cohort in Northeast China
Background: Sexually transmitted infections (STIs) increase HIV infectivity through local inflammatory processes. Prevalent and incident STIs among people who live with HIV/AIDS (PLWHA) are indicators of high-risk sexual behaviors and imply potential spread of HIV. Little is known about the prevalence and incidence of concurrent syphilis and associated risk behaviors among PLWHA in China. Methods: A retrospective cohort study was conducted among PLWHA who attended the outpatient clinic of a designated AIDS treatment hospital in Shenyang, China, between March 2009 and May 2013. Physical examinations and syphilis serology were conducted at each visit. A questionnaire on demographic characteristics was also collected. Results: A total of 1010 PLWHA were enrolled, of whom 77.0% were men who ha...
Stigmatizing attitudes towards people living with HIV/AIDS: validation of a measurement scale
Conclusions: The results of this study suggest that the SAT-PLWHA-S is a reliable and valid tool for measuring stigmatizing attitudes toward PLHIV and that it can contribute to a deeper understanding of HIV stigma. (Source: BMC Public Health)
E5564 inhibits immunosuppressive cytokine IL-10 induction promoted by HIV-1 Tat protein
Conclusion: This study provides compelling data showing for the first time that the TLR4 antagonist E5564 inhibits the immunosuppressive cytokine IL-10 production by primary human monocytes and macrophages incubated in the presence of HIV-1 Tat protein. (Source: Virology Journal)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Genetic Barrier to Resistance for Dolutegravir.
Authors: Llibre JM, Pulido F, García F, García Deltoro M, Blanco JL, Delgado R Abstract Dolutegravir is a novel integrase strand-transfer inhibitor that displays potent in vitro activity and a remarkably different resistance profile. Its robust pharmacokinetic/pharmacodynamic properties - long plasma t1/2, high plasma inhibition quotient, and slow dissociation rate from the integrase complex - suggest it should present a high barrier to resistance development. This has been confirmed in pivotal phase III studies of initial therapy, with none out of 1,118 treated individuals selecting resistance-associated mutations at the integrase or reverse transcriptase. In integrase-naive subjects with virological failure, a rescue intervention with dolutegravir has shown significantly higher...
Lipid Metabolism and Lipodystrophy in HIV-1-Infected Patients: The Role Played by Nonnucleoside Reverse Transcriptase Inhibitors.
Authors: Sension M, Deckx H Abstract Dyslipidemia and lipodystrophy represent significant healthcare concerns in HIV-infected patients due to their association with diabetes mellitus and increased cardiovascular disease risk. Since the lipid effects of the nonnucleoside reverse transcriptase inhibitors are not well characterized, we systematically summarized the effects of nonnucleoside reverse transcriptase inhibitor treatment on dyslipidemia and lipodystrophy in HIV-1 infection. As with other classes of antiretroviral agents, the nonnucleoside reverse transcriptase inhibitors are associated with lipid changes, although individual agents exhibit differing effects on lipid profiles. Comparative trials have shown that the risk for hypertriglyceridemia is lower with efavirenz than wi...
Risk Factors for Acquisition and Clearance of Oral Human Papillomavirus Infection Among HIV-Infected and HIV-Uninfected Adults.
Authors: Beachler DC, Sugar EA, Margolick JB, Weber KM, Strickler HD, Wiley DJ, Cranston RD, Burk RD, Minkoff H, Reddy S, Xiao W, Guo Y, Gillison ML, D'Souza G Abstract Human papillomavirus (HPV) causes the majority of oropharyngeal cancers in the United States, yet the risk factors for and natural history of oral HPV infection are largely unknown. In 2010-2011, a US-based longitudinal cohort study of 761 human immunodeficiency virus (HIV)-infected and 469 at-risk HIV-uninfected participants from the Multicenter AIDS Cohort Study and the Women's Interagency HIV Study was initiated. Semiannually collected oral rinses were evaluated for 37 HPV genotypes using the Roche LINEAR ARRAY HPV Genotyping Test (Roche Molecular Systems, Pleasanton, California), and factors associated with oral...
8 Animal Plagues Wreaking Havoc Right Now
This article originally appeared on World Science Festival. (Source: TIME.com: Top Science and Health Stories)
Uganda: Why We Should All Get Tested for HIV in 2014
[Key Correspondents]Two days after World AIDS Day (1 December), I'm sure many people will have put the issue of HIV out of their mind, but it's not an issue we can afford to think about just once a year. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Kenya: Pepfar Announces Latest Results in U.S. Government's Contribution to the HIV/Aids Response
[U.S. Embassy Nairobi]Washington, DC -Each year on World AIDS Day, The U.S. President's Emergency Plan for AIDS Relief (PEPFAR) announces its latest results. Since 2013, PEPFAR support in key program areas has expanded, including an increase in the number of people receiving live-saving antiretroviral treatment, pregnant woman receiving testing and counseling, and voluntary medical male circumcisions performed for HIV risk reduction. (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: Migori Reduces Rate of Mother to Child HIV Transmission From 5 to 3 Per Cent
[The Star]THE Migori government has reduced mother-to-child HIV transmission from more than five per cent last year to almost three per cent. (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: Get Tested, Oparanya to Residents
[The Star]A total of 57,952 people in Kakamega county were living with HIV-Aids by the end of last year, a new report shows. (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: Stigma Has Denied Children Treatment, Says Nyagarama
[The Star]ONLY 38 per cent of children living with HIV-Aids in Nyamira county are on antiretroviral treatment, Governor John Nyagarama has said. (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: Scourge Afflicts More Busia Women Than Men - Report
[The Star]MORE women than men are infected with HIV-Aids in Busia county, a report shows. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Kenya: Deliver in Hospital to Curb Virus Spread, Women Told
[The Star]Eighty-one per cent of children living with HIV-Aids in Kisii do not have access to antiretroviral therapy, county director of health Geoffrey Otomu said on Monday. (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: New Aids Infections in Kisumu Increase
[The Star]THE Kisumu government has raised the red flag over an increase in new HIV-Aids infections. (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: Migori Fights Mother-to-Child HIV Spread
[The Star]TRANSMISSION of HIV-Aids from mother to child has fallen from five to three per cent in Migori county, Governor Okoth Obado said on Monday. (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: County Plan On New Infections
[The Star]The county government on Monday unveiled new strategies to stop new HIV-Aids infections. (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: Support Syringe Project for Drug Users, Says NGO
[The Star]There are more than 4,000 Injection Drug Users living with HIV at the Coast, a study has shown. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Kenya: Kajiado Women Blame Men for HIV Infection
[The Star]Some Kajiado women have blamed their men for the spread of HIV-Aids. (Source: AllAfrica News: HIV-Aids and STDs)
Tanzania: Avoid Unsafe Sex to Avert HIV Infection Risk - RC
[Daily News]Tabora -TABORA Regional Commissioner, Mr Ludovick Mwananzila, has urged residents in the region to avoid engaging in unprotected sex to avert risks of increasing new HIV infections. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: Tenth Anniversary of Friends of the Global Fight
[Global Fund]Ten years ago, the late Jack Valenti, longtime head of the Motion Picture Association of America, joined philanthropist Ed Scott in founding Friends of the Global Fight to help promote U.S. investments in the fight against AIDS, tuberculosis and malaria, and to give the Global Fund a voice in Washington, D.C. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: 'Presidential Assent Can Stop HIV Stigma'
[Daily Trust]The National Agency for Control of AIDS (NACA) insists a presidential assent to an anti-stigma law can help the country's response to the virus. (Source: AllAfrica News: HIV-Aids and STDs)
Gambia: Health Minister Declares Gov't's Support to All HIV Infected Persons
[Daily Observer]The Health and Social Welfare minister, Omar Sey, has once again declared the government of The Gambia's support for all those who live with or are affected by HIV. He said the government has undertaken a lot of initiatives in providing more awareness as well as closing the gap between people who have access to HIV prevention, treatment, care and support services and those that are being left behind. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Africa: Southern Africa - The fight to end GBV and HIV & AIDS
[Gender Links]Maputo -According to the 2014 SADC Gender Protocol Barometer, HIV and AIDS prevalence has decreased consistently over the past decade as fewer people are becoming infected. New infections among adults have decreased by over 50% in Botswana, Malawi, Namibia, Zambia and Zimbabwe. New infections among adults have decreased by over 25% in Mozambique, South Africa and Swaziland. Despite this progress, Sub-Saharan Africa continues to be the most affected area in the world. SADC accounts for 55% of all people living with (Source: AllAfrica News: HIV-Aids and STDs)
South Africa: Tuberculosis Remains Leading Cause of Death
[SA Info]Tuberculosis remains the leading cause of death among South Africans, according to data released by Statistics South Africa (Stats SA) on Tuesday. (Source: AllAfrica News: HIV-Aids and STDs)
Sierra Leone: Ebola Overshadows Fight Against HIV/Aids
[IPS]Freetown -The outbreak of the deadly Ebola epidemic in Sierra Leone has dwarfed the campaign against HIV/AIDS, to the extent that patients no longer go to hospitals and treatment centres out of fear of contracting the Ebola virus. (Source: AllAfrica News: HIV-Aids and STDs)
Liberia: Same Sex Data Released
[NEWS]A fact sheet released Monday, December 1, 2014 at celebration of this year's World AIDS Day has indicated that an estimated 711 cases of men having sex with men (MSM). (Source: AllAfrica News: HIV-Aids and STDs)
Gambia: Gambia Celebrates World Aids Day Today
[Foroyaa]Gambia is celebrating World Aids Day today, Monday, 1st December, at Brikama, West Coast Region, as announced at a press briefing organised by the National Aids Secretariat (NAS) on Tuesday, 27 November 2014, at its office on t Kairaba Avenue. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Kenya: Bamzigi Helps Out Drug Addicts
[The Star]Producer and rapper Bamzigi has joined the fight to keep drug addicts from contracting HIV from sharing needles. (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: HIV Patients Skip Drugs, Says Council
[The Star]THERE are fears that more than 200 people living with HIV/Aids in Baringo county have defaulted in taking anti-retroviral drugs due to lack of constant reminders. (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: Nyandarua Aims to Cut HIV-Aids Infections By 25 Percent - Health Boss
[The Star]THE Nyandarua government has urged residents to get tested for HIV-Aids for the county to achieve its target of reducing infections by 25 per cent. (Source: AllAfrica News: HIV-Aids and STDs)
HIV positive woman finally has the family she always longed for
Johanna Satekge, 39, was diagnosed with HIV two months into her first pregnancy. Too afraid to admit to having the disease, her eldest children both fell victim to AIDS. (Source: the Mail online | Health)
Kenya: Upsurge in HIV\aids Cases Among Mother to Child
[The Star]THEIR is an increase in mother-to-child transmission of HIV-Aids cases this year. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Rwanda: Universities Should Have Clear Policies On HIV/Aids
[New Times]TODAY Rwanda will officially mark World Aids Day. The Day was globally commemorated on December 1. Globally about 34 million people are living with HIV, while more than 35 million people have died from Aids. UNICEF also reveals that at least 40 million people are infected with HIV in sub-Saharan Africa with the bulk of new cases among young people, aged 15-25. This is the age bracket where the majority of students in higher institutions of learning fall. Education Times assessed how universities in Rwanda (Source: AllAfrica News: HIV-Aids and STDs)
Zimbabwe: HIV Testing Overnight Clinic Opens in Gutu
[The Herald]Médecins Sans Frontières has introduced an overnight clinic in Gutu to provide HIV testing and counselling for men who shun the services during the day. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: 'Ending HIV, Aids Is Africa's Priority'
[The Herald]The African Union on Monday marked the World Aids Day in Victoria Falls where representatives of 47 African countries attended. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: Total Nationwide Campaign On Eradication of HIV/Aids in Nigeria Arrives Cross River
[Independent (Lagos)]Total companies in Nigeria led by Mrs. Elizabeth Proust, the Chief Executive Officer of Total Upstream of Nigeria and Mr. .Alexis Vovk, the Managing Director of Total Nigeria Plc, in order to maintain and sustain Corporate Social Responsibility (CSR) where oil and gas business is done in Nigeria, have commenced nationwide campaign to eradicate the scourge of HIV/ADIS and other related illnesses, such as tuberculosis, hepatitis-B and malaria. (Source: AllAfrica News: HIV-Aids and STDs)
Dummy
Click here to watch Team Haraa give us a hip hop low-down on their work: Hip Hip Haraa! 6 weeks in Haraa, it&#8217;s been real great Our team so safi, each other we don&#8217;t even hate We feel so karibu here, it&#8217;s home in our heart Hate to say baadae to our mamas and babas as we depart. We&#8217;ve been teaching in the school, the field, store fronts, to anyone who will listen 5 fluids, 4 doors, and 3 ways of transmission On testing day the people came out and our goals we bested, For the only way to know your status is to get tested People dragged out their friends, the whole event was quite grand, The future of Haraa was in their hand Supporting each other even when results were feared, Tuko Pamoja Kuushinda UKIMWI, together we cheered! We taught a bunch, but learned even more, ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Priapism: comorbid factors and treatment outcomes in a contemporary series.
Conclusions. We describe the characteristics and outcomes of a large group of patients with priapism. Our experience at a tertiary care center indicates that mental illness, including substance abuse disorders, is a highly prevalent comorbid condition in men who experience priapism. Consistent with previous reports, erectile dysfunction is the most common complication from priapism and its treatment, occurring in the majority of men. PMID: 22811705 [PubMed] (Source: Advances in Urology)
Circumcision cited as defense against HIV in proposed CDC guidelines
The Centers for Disease Control and Prevention has released proposed guidance on circumcision that says the surgical procedure would help straight men in the United States reduce their risk of becoming infected with HIV, the virus that causes AIDS. (Source: Los Angeles Times - Science)
HIV evolving to weaker form, study says
Medical intervention and the natural course of evolution may be dealing a double blow to the human immunodeficiency virus, HIV-1, weakening its ability to replicate and to cause AIDS, according to a new study. (Source: Los Angeles Times - Science)
CDC: Advise Hetero Men, Boys, on HIV Benefit of CircumcisionCDC: Advise Hetero Men, Boys, on HIV Benefit of Circumcision
Proposed guidance for clinicians states that the procedure evidently reduces the risk for HIV infection in heterosexual males, but not for men having sex with men. Medscape Medical News (Source: Medscape Infectious Diseases Headlines)
More Testing, Treatment Needed to Achieve National HIV Targets
Efforts to prevent and treat HIV have to be intensified among gay, bisexual, and other men who have sex with men (MSM) to meet the goals of the National HIV/AIDS Strategy. Men who have sex with men carry the highest burden of HIV infection; among those newly infected in 2010, 63% were MSM, a group that also comprised 52% of people living with HIV. By 2015, the National HIV/AIDS Strategy calls for 85% of MSM diagnosed with HIV to be linked with clinical care within 3 months of diagnosis, 80% to be receiving care, and the proportion with an undetectable viral load to be increased by 20%. (Source: JAMA)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
World AIDS Day 2014
Since 1987 people around the world have marked Dec. 1 as a day to raise awareness of HIV/AIDS (Source: Health News: CBSNews.com)
Circumcision Benefits Outweigh Risks, Says New CDC Guidelines
NEW YORK (AP) ? U.S. health officials on Tuesday released a draft of long-awaited federal guidelines on circumcision, saying medical evidence supports having the procedure done and health insurers should pay for it. The Centers for Disease Control and Prevention guidelines stop short of telling parent to get their newborn sons circumcised. That is a personal decision that may involve religious or cultural preferences, said the CDC's Dr. Jonathan Mermin. But "the scientific evidence is clear that the benefits outweigh the risks," added Mermin, who oversees the agency's programs on HIV and other sexually transmitted diseases. These are the first federal guidelines on circumcision, a brief medical procedure that involves cutting away the foreskin around the tip of the penis. Germs can gro...
Individual- and community-level influences on the timing of sexual debut among youth in Nyanza, Kenya.
CONCLUSION: Community-level variables are frequently associated with sexual debut and should be included in future research. PMID: 25051578 [PubMed - in process] (Source: International Perspectives on Sexual and Reproductive Health)
Understanding global trends in maternal mortality.
CONCLUSIONS: Although the estimated annual rate of decline in the global MMR in 1990-2008 (2.3%) fell short of the level needed to meet the MDG 5 target, it was much faster than had been thought previously. Targeted efforts to improve access to quality maternal health care, as well as efforts to decrease unintended pregnancies through family planning, are necessary to further reduce the global burden of maternal mortality. PMID: 23584466 [PubMed - indexed for MEDLINE] (Source: International Perspectives on Sexual and Reproductive Health)
Maternal health care utilization among HIV-positive female adolescents in Kenya.
CONCLUSION: Pregnant, HIV-positive adolescents need maternal health care services--including PMTCT care--that take into account parity, paternity dynamics and regional variations in use. PMID: 21988790 [PubMed - indexed for MEDLINE] (Source: International Perspectives on Sexual and Reproductive Health)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
STI treatment-seeking behaviors among youth in Nigeria: are there gender differences?
CONCLUSION: Programs and policies that aim to increase treatment of STIs among young people in Nigeria need to target males and females differently. PMID: 20663743 [PubMed - indexed for MEDLINE] (Source: International Perspectives on Sexual and Reproductive Health)
CDC Endorses Circumcision for Health Reasons
Says benefits, including reduced chances of sexually transmitted diseases, outweigh risksSource: HealthDay Related MedlinePlus Pages: Circumcision, HIV/AIDS, Sexually Transmitted Diseases (Source: MedlinePlus Health News)
UCLA study: To stop spread of HIV, African governments should target hot zones
David Gerberry Efficiency of reducing transmission of HIV in South African provinces, from red (best) to orange (moderate) to green (worst). Blue and pink bars show prevalence of HIV for men and women, respectively. While Ebola has attracted much of the world?s attention recently, a severe HIV epidemic rages on around the world and in sub-Saharan Africa in particular. Globally, more than 34 million people are infected with HIV; in sub-Saharan Africa alone, 3 million new infections occur annually. In an attempt to stop the spread of HIV, governments in the region are considering providing antiretroviral drugs to people who do not have the virus but are at risk for becoming infected. Such drugs are known as pre-exposure prophylaxis, or PrEP. Although the conventional strategy ? attempti...
NIH statement on World AIDS Day 2014
Remarkable progress has been made in the fight against HIV/AIDS since the first annual World AIDS Day was commemorated 26 years ago. Yet, we are still far from achieving our goal of a world without AIDS.   Statement by  Anthony S. Fauci, M.D. Director, National Institute of Allergy and Infectious Diseases Jack Whitescarver, Ph.D., Director, NIH Office of AIDS Research Francis S. Collins, M.D., Ph.D, NIH Director (Source: NIAAA News)
Gambia: Close the Gap This World Aids Day
[The Point]The Gambia joined the rest of the world on Monday 1st December to commemorate World AIDS Day. World AIDS Day offers an opportunity to harness the power of social change to put people first and close the gap. According to UNAIDS, ending the AIDS epidemic by 2030 is possible, but only by closing the gap between people who have access to HIV prevention, treatment, care and support services and people who are being left behind. The theme for this year's commemoration is Close the Gap. (Source: AllAfrica News: Health and Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
NIH statement on World AIDS Day 2014
Remarkable progress has been made in the fight against HIV/AIDS since the first annual World AIDS Day was commemorated 26 years ago. (Source: National Institutes of Health (NIH) News Releases)
South Africa: Should HIV Testing Become a Standard Medical Procedure?
[The Daily Vox]Knowing your status is the key to ending the Aids pandemic but still too few South Africans take the step to get tested for HIV. A report in the Mail & Guardian this week less than a third of the country's 35-million sexually active people get tested for HIV annually. (Source: AllAfrica News: Health and Medicine)
Recommendations for Providers Counseling Male Patients and Parents Regarding Elective Male Circumcision and the Prevention of HIV Infection, STIs, and Other Health Outcomes.
CDC Announces Public Comment Period On Draft Provider Counseling Recommendations For Male Circumcision (Source: CDC HIV/AIDS Prevention)
Lesotho: Want to Know Prince Harry's Secret As He Campaigns On Aids?
[Thomson Reuters Foundation]London -Britain's Prince Harry revealed one of his biggest fears on Monday - public speaking - as he coaxed other celebrities to speak out about their secret anxieties as part of an online campaign to reduce stigma associated with HIV/AIDS. (Source: AllAfrica News: Health and Medicine)
Africa: Lack of Access to Clean Water Hampers Fight Against Aids
[Thomson Reuters Foundation]London -Lack of access to clean water and basic sanitation in southern Africa hampers the fight against HIV/AIDS by reducing the effectiveness of life-saving drugs, according to a study marking World AIDS Day. (Source: AllAfrica News: Health and Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Africa: Global Fund Reports Results - 2014
[Global Fund]Geneva -The Global Fund to Fight AIDS, Tuberculosis and Malaria today announced new results that show acceleration in efforts to end the AIDS epidemic. In the past year, an additional 1.3 million people began treatment for HIV in programs supported by the Global Fund, a 20 percent increase, bringing the total to 7.3 million people. (Source: AllAfrica News: Malaria)
Algeria: Algeria, a Model Country in Fight Against HIV/Aids
[Algerie Presse Service]Oran -United Nations Resident Coordinator in Algeria Cristina Amaral said Monday in Oran that Algeria is a model country in fight and prevention against HIV/AIDS. (Source: AllAfrica News: Health and Medicine)
The regulation of inflammatory pathways and infectious disease of the cervix by seminal fluid.
Authors: Adefuye A, Katz AA, Sales KJ Abstract The connection between human papillomavirus (HPV) infection and the consequent sequelae which establishes cervical neoplastic transformation and invasive cervical cancer has redefined many aspects of cervical cancer research. However there is still much that we do not know. In particular, the impact of external factors, like seminal fluid in sexually active women, on pathways that regulate cervical inflammation and tumorigenesis, have yet to be fully understood. HPV infection is regarded as the initiating noninflammatory cause of the disease; however emerging evidence points to resident HPV infections as drivers of inflammatory pathways that play important roles in tumorigenesis as well as in the susceptibility to other infections such...
Mycobacterium genavense Infections in a Tertiary Hospital and Reviewed Cases in Non-HIV Patients.
We describe clinical and laboratory features and response to therapy in 7 patients, three of them with HIV infection and four non-HIV-three organ transplant recipients and one with hyper-IgE syndrome-in Valencia, Spain, in a ten years period. We then summarize the published cases of M. avium complex infection, with invasion of peripheral blood, liver, spleen, bone marrow, lymph nodes, and lungs. In clinical samples a large number of acid-fast bacilli were observed. M. genavense grew only from liquid media and after a prolonged incubation period. Its identification was accomplished through molecular methods. Patients were treated with prolonged combinations of antimicrobial agents. There was clinical favourable outcome in 4 patients. PMID: 24693456 [PubMed] (Source: Pathology Research ...
Neuroinflammation as the proximate cause of signature pathogenic pattern progression in amyotrophic lateral sclerosis, AIDS, and multiple sclerosis.
Authors: Agius LM Abstract The realization of injury to large motor neurons is embedded within contextual reference to the parallel pathways of apoptosis and necrosis of system-patterned evolution. A widespread loss of cell components occurs intracellularly and involves a reactive participation to a neuroinflammation that potentially is immunologically definable. In such terms, sporadic and hereditary forms of amyotrophic sclerosis are paralleled by the components of a reactive nature that involve the aggregation of proteins and conformational misfolding on the one hand and a powerful oxidative degradation that overwhelms the proteasome clearance mechanisms. In such terms, global participation is only one aspect of a disorder realization that induces the development of the defining...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
False-Negative Results of Endoscopic Biopsy in the Diagnosis of Gastrointestinal Kaposi's Sarcoma in HIV-Infected Patients.
In conclusion, FNRs were found in 35.3% of GI-KS lesions and were especially related to the site of the esophagus and endoscopic early stage (small size or patch appearance). An SMT with ulceration may be relatively easy to diagnose on endoscopic biopsy. Caution should be exercised when performing endoscopic biopsy of these lesions in AIDS patients and evaluating the histological features. PMID: 23227427 [PubMed] (Source: Pathology Research International)
AIDS-Related Pathology.
Authors: Pantanowitz L, Carbone A, Stebbing J PMID: 21845208 [PubMed] (Source: Pathology Research International)
The emerging case for shared decision making in orthopaedics.
Authors: Youm J, Chenok KE, Belkora J, Chiu V, Bozic KJ Abstract The Institute of Medicine outlined a standard for patient-centered care, which has become the centerpiece of healthcare reform in the United States. Shared decision-making interventions, which include decision and communication aids, are formal embodiment of this philosophy. Although the concept of shared decision making has been shown to be an effective tool, and its relevance to orthopaedic medicine has been well documented, it has not been widely adopted by orthopaedic surgeons. It is helpful to examine the benefits of shared decision making, along with incentives to encourage adoption and implementation of this important philosophy. PMID: 23395061 [PubMed - indexed for MEDLINE] (Source: Instructional Course Le...
HIV evolving into less deadly form
ConclusionThis study shows that HIV adapts to a person?s immune system, and that some of these adaptations may reduce the virulence of the virus. It appears that over time, the virulence of HIV in Botswana has decreased compared with HIV in South Africa, because of such adaptations and the use of HIV drugs. Specific HLA proteins present in adults in Botswana have, over time, forced the virus to change into less virulent forms, allowing it to survive, replicate and spread.This is consistent with a broader theory that epidemic viruses get less virulent over time, due to natural selection. The most severe viruses kill their hosts too early to be passed on. Hence, eventually, the very severe strains die out or mutate into milder forms. This study furthers our understanding of the evolution o...
Children's catching performance when the demands on the postural system is altered.
Authors: Angelakopoulos GT, Tsorbatzoudis H, Grouios G Abstract In many dynamic interceptive actions performers need to integrate activity of manual and postural subsystems for successful performance. Groups of different skill level (poor and good catchers), (mean age = 9.1 and 9.4 respectively) were required to perform one-handed catches under different postural constraints: standing; standing in contact with a postural support aid by their side (PSAS) or to the left of their trunk (PSAF); Tandem; and sitting (control). Results revealed that, for poor catchers, the number of successful catches increased and grasp errors decreased significantly when sitting and with both postural aids in comparison with standing alone and Tandem conditions. Kinematic analyses showed that the postur...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
VIDEO: Tackling HIV in Myanmar
As access to Myanmar increases, is the country left more vulnerable to diseases such as HIV/Aids? Nick Wood reports. (Source: BBC News | Health | UK Edition)
HIV and AIDS surveillance.
Authors: PMID: 23841191 [PubMed - indexed for MEDLINE] (Source: Communicable Diseases Intelligence Quarterly Report)
WHO Simplifies Advice on HIV Post-Exposure Prophylaxis WHO Simplifies Advice on HIV Post-Exposure Prophylaxis
After any kind of exposure to the virus, the UN agency recommends a cocktail of three antiretrovirals, the same basic regimen for treating individuals infected with HIV. Medscape Medical News (Source: Medscape Medical News Headlines)
Recommendations for Providers Counseling Male Patients and Parents Regarding Elective Male Circumcision and the Prevention of HIV Infection, STIs, and Other Health Outcomes.
CDC Announces Public Comment Period On Draft Provider Counseling Recommendations For Male Circumcision (Source: CDC HIV/AIDS Prevention)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Rwanda: Experts - No Room for Complacency in Aids Fight
[New Times]There shouldn't be room for complacency if the fight to eliminate HIV/Aids is to ever achieve victory. (Source: AllAfrica News: HIV-Aids and STDs)
South Africa: HIV, TAC and the Struggle for Life
[Daily Maverick]To mark World Aids Day, the Treatment Action Campaign (TAC) held a reunion on Monday to honour how far we've come in the fight against HIV/AIDS and remind how far there is to go. In this struggle, the enemy might not be as clear but the fight for life continues and TAC is an integral voice. (Source: AllAfrica News: HIV-Aids and STDs)
Rwanda: 300 Expectant Mothers Receive 'Mama Kits'
[New Times]A total of 300 expectant mothers from Association Impore are set to benefit from 'mama kits' donated by Airtel Rwanda in an effort to help reduce mother-to-child HIV transmission. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: 30,000 People Receiving HIV/Aids Treatment in Taraba
[Daily Trust]Jalingo -About 30,000 people of the estimated 150,000 persons living with HIV/AIDS (PLWHA) in Taraba State are currently on treatment. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: NACA Demands N15 Billion to Put More HIV Positive Persons On Treatment
[Guardian]WITH 152,000 more Nigerians and 2.3 million people globally accessing treatment for Human Immuno-deficiency Virus (HIV)/Acquired Immune Deficiency Syndrome (AIDS) in the last one year, and fewer persons, from 2.2 million in 2012 to 2.1 million in 2013, getting infected with the virus, the world is closer than ever to the end of the pandemic. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Kenya: More Women HIV-Positive
[The Star]THE HIV prevalence among women in Mombasa is higher than that of men. (Source: AllAfrica News: HIV-Aids and STDs)
Auricular involvement of a multifocal non-AIDS Kaposi's sarcoma: a case report.
Authors: Busi M, Altieri E, Ciorba A, Aimoni C Abstract Kaposi's sarcoma (KS) is a multicentric, malignant neoplastic vascular disease, mainly involving skin and mucosae, characterised by the proliferation of endothelial cells. The aetiology of KS still is unknown. Nonetheless, it has been reported that several epidemiological and environmental factors may play a role in its pathogenesis. Viral factors (i.e. human herpes virus 8, HHV-8) have also been claimed to play a role in the onset of KS. Four main clinical presentations of KS have been described: classic (sporadic), African (endemic), iatrogenic (immunosuppression-associated) and AIDS-associated (epidemic). The authors present a case of KS involving the external ear of a HIVnegative patient with a history of non-Hodgkin lymph...
Quantitative enhancement of speech in noise through a wireless equipped hearing aid.
Authors: Ciorba A, Zattara S, Loroni G, Prosser S Abstract The development of new hearing aid technology can improve speech understanding in complex listening environments. The purpose of this study is to evaluate the benefit offered by the use of wireless technology applied to hearing aids. Participants were fit with binaural hearing instruments and underwent speech-in-noise tests. The signal was transmitted either by a speaker or wirelessly directly to the hearing aid. In our experience, hearing aids with wireless systems have an advantage in two particular conditions. The first can be achieved while listening wirelessly with microphones excluded (recommended when listening in noisy environments), while the second is in conditions of asymmetric listening; the wireless signal perc...
Hearing loss: The worrying rise and rise of hidden hearing loss
More than ten million Britons ? one in six ? are thought to have some hearing loss, yet many wait years before seeking help. Jackie Hunt, 44, was shocked to find out she needed two hearing aids. (Source: the Mail online | Health)
Advantages of binaural amplification to acceptable noise level of directional hearing aid users.
CONCLUSION: Binaural directional microphone processing allowed hearing aid users to accept a greater amount of background noise, which may in turn improve listeners' hearing aid success. Informational masking substantially influenced background noise acceptance. Given a significant association between ANLs and duration of hearing aid usage, ANL measurement can be useful for clinical counseling of binaural hearing aid candidates or unsuccessful users. PMID: 24917904 [PubMed] (Source: Clinical and Experimental Otorhinolaryngology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
AIDS pandemic has finally reached 'the beginning of the end' after 30 years, campaigners say
But the ONE campaign, an advocacy group working to end poverty and preventable disease in Africa, warned this milestone didn't mean the end was imminent. (Source: the Mail online | Health)
Serum interleukin-22 (IL-22) is increased in the early stage of Hashimoto's thyroiditis compared to non-autoimmune thyroid disease and healthy controls.
CONCLUSIONS: Serum IL-22 is increased in newly diagnosed, untreated HT patients, as compared to thyroid autoimmune disease-free individuals. Our data suggest that IL-22 could play some role in the development of HT. PMID: 25079457 [PubMed - in process] (Source: Hormones)
Design and pharmaceutical evaluation of a nano-enabled crosslinked multipolymeric scaffold for prolonged intracranial release of Zidovudine.
CONCLUSIONS: The crosslinked multipolymeric scaffold loaded with alginate nanoparticles and treated with 1% HCl showed the potential for prolonged delivery of zidovudine over a period of 30 days and therefore may be a potential candidate for use as an implantable device in treating Aids Dementia Complex. PMID: 24021294 [PubMed - indexed for MEDLINE] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Kenya: First Lady - Beyond Zero Initiative Will Help Combat HIV/Aids
[Capital FM]Kilifi -The 'Beyond Zero' initiative will be used to combat HIV/AIDS besides reducing maternal and child mortality, First Lady Margaret Kenyatta has said. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Ghana: Ensure a Free HIV Generation
[Ghana Govt.]The Deputy Eastern Regional Minister, Madam Mavis Frempong, has called on Ghanaians to check their HIV status on regular basis to enable Ghana attain its goal of a free HIV generation. (Source: AllAfrica News: HIV-Aids and STDs)
Flax and flaxseed oil (Linum usitatissimum): a review by the Natural Standard Research Collaboration.
The objective of this study was to evaluate the scientific evidence on flaxseed, including expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing. Electronic searches were conducted in 9 databases, 20 additional journals (not indexed in common databases), and bibliographies from 50 selected secondary references. No restrictions were placed on the language or quality of the publications. All literature collected pertained to efficacy in humans, dosing, precautions, adverse effects, use in pregnancy/lactation, interactions, alteration of laboratory assays, and mechanisms of action. Standardized inclusion/exclusion criteria are used for selection. Grades were assigned using an evidence-based grading rationale. A rev...
Associations between public health indicators and injecting prescription opioids by prescription opioid abusers in substance abuse treatment.
CONCLUSIONS: This study demonstrates an approach to measure the potential impact of injecting prescription opioids on public health indicators. Findings indicate a positive association between injection of prescription opioids and public health indicators suggesting a need for prescription opioid formulations that may inhibit injection of these medications. PMID: 23709299 [PubMed - indexed for MEDLINE] (Source: Journal of Opioid Management)
HIV is turning into AIDS more slowly, study finds
Thor BensonLONDON, Dec. 1 (UPI) -- As HIV evolves as a virus and adapts to the human immune system, a new study finds it becomes less deadly and takes longer to turn into AIDS. (Source: Health News - UPI.com)
Culture Shock: 27 World AIDS Days and Counting
(MedPage Today) -- But an ambitious program aims to eliminate the HIV/AIDS pandemic. (Source: MedPage Today Public Health)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
HIV's ability to cause AIDS is weakening over time, study finds
Rapid evolution of HIV, the human immunodeficiency virus, is slowing its ability to cause AIDS, according to a study of more than 2,000 women in Africa. (Source: the Mail online | Health)
On the Efficacy and Mediation of a One-on-One HIV Risk-Reduction Intervention for African American Men Who Have Sex with Men: A Randomized Controlled Trial
In conclusion, although BRO increased several theoretical constructs, most of those constructs did not predict consistent condom use; hence, the intervention did not increase it. Theoretical constructs that interventions should target to increase African American MSM?s condom use are discussed. (Source: AIDS and Behavior)
Colitis cystica profunda indefinite for dysplasia in Crohn disease: A potential diagnostic pitfall
We present a challenging case of CCP in the setting of Crohn disease (CD) containing foci of atypical epithelium. A right hemicolectomy from a 46-year-old woman contained a stricture associated with a proximal multilocular cystic lesion containing mucin-filled glands dissecting through the colonic wall. These glands had lobulated architecture with smooth contours surrounded by lamina propria and lacking desmoplastic stroma. The epithelium had focal nuclear crowding, enlargement, and hyperchromasia, with increased nucleus to cytoplasm ratio, but overall preserved polarity. Atypical cells were focally positive for CK7 and p53, with increased MIB-1 staining. These findings were interpreted as indefinite for dysplasia. Chronic transmural inflammation and mucosal regeneration probably facilitat...
Risk and Protective Factors for Physical and Sexual Abuse of Children and Adolescents in Africa: A Review and Implications for Practice
There is now conclusive evidence of the major and long-lasting negative effects of physical and sexual abuse on children. Within Africa, studies consistently report high rates of child abuse, with prevalence as high as 64%. However, to date, there has been no review of factors associated with physical and sexual child abuse and polyvictimization in Africa. This review identified 23 quantitative studies, all of which showed high levels of child abuse in varying samples of children and adults. Although studies were very heterogeneous, a range of correlates of abuse at different levels of the Model of Ecologic Development were identified. These included community-level factors (exposure to bullying, sexual violence, and rural/urban location), household-level factors (poverty, household violen...

 

 


   Origin of HIV/AIDS
By Anil Shaw
 Origin of HIV/AIDSMost people believe that the origin of HIV, the AIDS virus, derives from some natural evolutionary event. The HIV origin theories is called "cut hunter Read more...

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