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CD4 Cells
By Afsath Jameela

CD4 Cells
Treatment centers need consulting rooms, offices, waiting rooms and secure storage for valuable drugs. They also require basic facilities to test for anemia, pregnancy, renal function, white blood cell counts and other factors that may affect treatment.
In developed countries, decisions about when to start treatment are based on the results of clinical tests called the CD4 test and the viral load test. Ideally these tests should be used everywhere, but in many parts of the world they are currently unavailable, as they require expensive equipment, electricity and trained technicians. In theory, decisions about when to start treatment may be based on symptoms alone. However in practice some treatment programmers provide medication only to people who have had a CD4 count.
There are two primary types of T-cells.
1. CD4 Cells-These cells have molecules called CD4 on its surface. These "helper" cells initiate the body's response to invading micro-organisms such as viruses.
2.CD8 Cells-These types of T-cells have a molecule called CD8 on their surface. CD8 cells destroy cells that have been infected with foreign invading micro-organisms. CD8 cells also produce antiviral substances (antibodies) that help fight off the foreign invader.
3.Normal values-In a healthy adult, a normal CD4 count can vary a great deal but is typically 600 to 1200 cells per cubic millimeter of blood
Between 600 and 350- In an HIV+ person, this range is considered "very good".
HIV medications are typically not be indicated.
Between 350 and 200-The immune system is weakened and therefore the HIV+ person may be at increased risk for infection and illness.
Function of T helper cells: Antigen presenting cells present antigen on their Class II MHC molecules. Helper T cells recognize these, with the help of their expression of CD4 co-receptor. The activation of a resting helper T cell causes it to release cytokines and other stimulatory signals. The importance of CD4 T cells is demonstrated with infection.
It has been proposed that during the non-symptomatic phase of infection, the virus has a relatively low affinity towards T cells (and has a higher affinity for macrophages), resulting in a slow kill rate of CD4+ T cells by the immune system. This is initially compensated for via the production of new helper T cells from thymus. Once the virus becomes T-tropic, it begins to infect CD4+ T cells far more efficiently, and

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the immune system is overwhelmed.
At this point, functional CD4+ T cell levels begin to decrease, eventually to a point where the CD4+ T cell population is too small to recognize the full range antigens that could potentially be detected. The lack of full antigen cover results in the core symptoms of acquired immune deficiency syndrome (AIDS).CD4 T cell depletion during AIDS allows various pathogens to escape T cell recognition, thus allowing opportunistic infections that would normally elicit a helper T cell response to bypass the immune system. While these complete bypass situations only occur when the helper T cell response is absolutely necessary for infection clearance, most infections increase in severity and/or duration because the immune system's helper T cells provide a weaker contribution to a less efficient immune response.
Two components of the immune system are particularly affected in AIDS, due to its CD4+ T cell dependency:
CD8+ T cells are not stimulated as effectively during the AIDS period of infection, making AIDS patients very susceptible to most viruses, including itself. This decline in killing of CD4+ T cells results in the virus being produced for a longer period (the infected CD4+ T cells are not killed as quickly), increasing the proliferation of the virus, and accelerating the development of the disease.
Antibody class switching declines significantly once helper T cell function fails. The immune system loses its ability to improve the affinity of their antibodies, and are unable to generate B cells that can produce antibody groups such as IgG and IgA. These effects are primarily due to the loss of any helper T cell that can interact with the B lymphocyte correctly. Another symptom of AIDS is the reduction in antibody levels due to a decrease in Th2 cytokines (and less interactions by helper T cells). All of these complications result in an increased susceptibility to aggressive bacterial infections, especially in areas of the body not accessible by IgM antibodies.
If the patient does not respond to Treatment they will succumb usually to either cancers or infections; the immune system finally reaches a point where it is no longer coordinated or stimulated enough to deal with the disease.

 Keywords:  HIV,AIDS,HIV Cure,HIV Treatment,HIV Infection,HIV Dating,HIV Positive,HIV Symptoms.


Afsath Jameela is a successful lady writer from Kairo. She right now living in UK.

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Source: Food and Drug Administration Related MedlinePlus Pages: HIV/AIDS, HIV/AIDS Medicines (Source: MedlinePlus Health News)
Effects of Noise Reduction on AM Perception for Hearing-Impaired Listeners
ABSTRACT Noise reduction (NR) systems are commonplace in modern digital hearing aids. Though not improving speech intelligibility, NR helps the hearing-aid user in terms of lowering noise annoyance, reducing cognitive load and improving ease of listening. Previous psychophysical work has shown that NR does in fact improve the ability of normal-hearing (NH) listeners to discriminate the slow amplitude-modulation (AM) cues representative of those found in speech. The goal of this study was to assess whether this improvement of AM discrimination with NR can also be observed for hearing-impaired (HI) listeners. AM discrimination was measured at two audio frequencies of 500 Hz and 2 kHz in a background noise with a signal-to-noise ratio of 12 dB. Discrimination was measured for ten...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Detection of Modulated Tones in Modulated Noise by Non-human Primates
Abstract In natural environments, many sounds are amplitude-modulated. Amplitude modulation is thought to be a signal that aids auditory object formation. A previous study of the detection of signals in noise found that when tones or noise were amplitude-modulated, the noise was a less effective masker, and detection thresholds for tones in noise were lowered. These results suggest that the detection of modulated signals in modulated noise would be enhanced. This paper describes the results of experiments investigating how detection is modified when both signal and noise were amplitude-modulated. Two monkeys (Macaca mulatta) were trained to detect amplitude-modulated tones in continuous, amplitude-modulated broadband noise. When the phase difference of otherwise similarly amplitu...
Africa: Fashion Designer Victoria Beckham Joins UN Effort to Achieve World Free of HIV
[UN News]The Joint United Nations Programme on HIV/AIDS (UNAIDS) today appointed British fashion designer Victoria Beckham as its International Goodwill Ambassador, with a focus on women and children affected by the virus. (Source: AllAfrica News: HIV-Aids and STDs)
National Gay Men's HIV/AIDS Awareness Day ? September 27, 2014
(Source: CDC Morbidity and Mortality Weekly Report)
Tanzania: HIV/Aids Infection Rate Increases in Kagera
[Daily News]Bukoba -AUTHORITIES in Kagera Region are alarmed following reports that the rate of HIV/AIDS infections increased from 3.4 per cent recorded during 2008 to 4.8 per cent, this year. (Source: AllAfrica News: HIV-Aids and STDs)
Roche launches Global Access Program for HIV viral load testing
Roche announced today the launch of a new Global Access Program for HIV viral load testing, created in partnership with UNAIDS, the joint United Nations Program on HIV/AIDS, the Clinton Health Access Initiative (CHAI), the President&#8217;s Emergency Plan For AIDS Relief (PEPFAR) and the Global Fund to fight AIDS, TB &#038; Malaria, at a high-level side event held during the 69th session of the United Nations General Assembly in New York, USA. (Source: Roche Media News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Molecular typing of clinical Cryptococcus neoformans isolates collected in Germany from 2004 to 2010
Abstract Cryptococcosis is a fungal infection mostly caused by Cryptococcus neoformans. We identified agents of cryptococcosis diagnosed in Germany from 2004 to 2010. We used multi-locus sequence typing (MLST) to understand the molecular epidemiology of cryptococcosis. Sero- and mating types of individual patient isolates were determined by PCR. MLST was performed using the seven-locus scheme. Allele and nucleotide diversity was calculated for each locus of C. neoformans var. grubii and C. neoformans var. neoformans. Phylogenetic relations were assessed by dendrograms. Clinical data were compared between infections caused by the two variants. We studied 101 isolates. Eight were identified as hybrids (8 %). All non-hybrids were of the ? mating type. Among 78 C. neoformans var. g...
Health-related quality of life following radical prostatectomy: long-term outcomes
Conclusion Overall HRQoL, sexual drive, sexual function, energy and bladder control do not return to preoperative levels within 30 months post-RP. Black patients experience the greatest reductions in HRQoL. HRQoL losses may be ameliorated by use of pro-erectile aids. These findings help to identify at-risk patient populations and inform survivorship programs. (Source: Quality of Life Research)
HIV preventive behavior and associated factors among mining workers in Sali traditional gold mining site bench maji zone, Southwest Ethiopia: a cross sectional study
Conclusions: The HIV preventive behavior of the mining worker was low. Being engaged in sexual intercourse with one sexual partner is very low, Consistent condom use among these mining workers was low. Income, educational status and self efficacy have significant effect on the HIV preventive behavior of mining workers. Thus this population group should be understood as at risk population at national level. (Source: Epidemiologic Perspectives and Innovations)
Scrambling for Africa: AIDS, Expertise, and the Rise of American Global Health Science. Edited by Johanna Tayloe Crane. 224 pp. Ithaca: Cornell University Press. 2013. $89.95 (cloth), $27.95 (paper).
(Source: American Journal of Human Biology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
FDA Approves Two Medications to Treat HIV Infection: Cobicistat (Brand Name: Tybost) and Elvitegravir (Brand Name: Vitekta)
&quot;On September 24, 2014, FDA approved Tybost (cobicistat) 150 mg tablets. Tybost is a CYP3A inhibitor indicated to increase systemic exposure of atazanavir or darunavir (once daily dosing regimen) in combination with other antiretroviral agents in the treatment of HIV-1 infection.&quot; For more information on cobicistat, view the FDA press release. &quot;On September 24, 2014, FDA approved Vitekta (elvitegravir) 85 mg and 150 mg tablets. Vitekta is a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor indicated in combination with an HIV protease inhibitor coadministered with ritonavir and with other antiretroviral drug(s) for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults.&quot; For more information on elvitegravir, view...
CDC Seeks Public Comments on Newly Developed Draft Clinical Quality Measure for HIV Screening
The Centers for Disease Control and Prevention (CDC)&nbsp;is seeking public comments on a newly developed draft clinical quality measure for HIV infection screening. The measure aligns with the U.S. Preventive Services Task Force (USPSTF) recommendations that all individuals between the ages of 15 and 65 be screened for HIV. The measure was developed in collaboration with clinicians and quality experts. The goal is to develop a measure that will be nationally endorsed through the National Quality Forum (NQF) and included in the Centers for Medicare and Medicaid Services (CMS) programs. Public comments will be accepted through October 20, 2014. For information on how to submit comments, please view the&nbsp;public notice on the CMS website. (Source: AIDSinfo At-a-Glance: Offering Informati...
CDC Launches HIV Treatment Works Campaign
CDC recently launched&nbsp;HIV Treatment Works, a new national campaign focused on encouraging people infected with HIV to get into care and adhere to treatment. The website includes information and resources for people living with HIV, including information on treatment adherence and tips for healthy living. Visit the&nbsp;HIV Treatment Works&nbsp;website to find an HIV care provider, an HIV support group, or mental health provider. For more information, view the&nbsp;CDC press release.&nbsp; (Source: AIDSinfo At-a-Glance: Offering Information on HIV/AIDS Treatment, Prevention, and Research, A Service of the U.S. Department of Health and Human Services (DHHS))
September 27 is National Gay Men?s HIV/AIDS Awareness Day
September 27 is the annual observance of National Gay Men&rsquo;s HIV/AIDS Awareness Day, which serves to highlight the continuing impact of the HIV/AIDS epidemic among gay men. Gay and bisexual men are more severely affected by HIV than any other group in the United States. According to&nbsp;CDC, gay, bisexual, and other men who have sex with men (MSM) represent approximately 2% of the U.S. population but accounted for 63% of estimated new HIV infections in 2010. Explore our&nbsp;National Gay Men&rsquo;s HIV/AIDS Awareness Day webpage&nbsp;[en espa&ntilde;ol] to learn more about this observance and to find information on HIV/AIDS and gay men. (Source: AIDSinfo At-a-Glance: Offering Information on HIV/AIDS Treatment, Prevention, and Research, A Service of the U.S. Department of Health and...
Men Living with Diagnosed HIV Who Have Sex with Men: Progress Along the Continuum of HIV Care - United States, 2010.
Authors: Singh S, Bradley H, Hu X, Skarbinski J, Hall HI, Lansky A Abstract Gay, bisexual, and other men who have sex with men (MSM) represent approximately 2% of the United States population, yet are the risk group most affected by human immunodeficiency virus (HIV). In 2010, among persons newly infected with HIV, 63% were MSM; among persons living with HIV, 52% were MSM. The three goals of the National HIV/AIDS Strategy are to reduce new HIV infections, to increase access to care and improve health outcomes for persons living with HIV, and to reduce HIV-related health disparities. In July 2013, the HIV Care Continuum Initiative was established by executive order to mobilize and accelerate federal efforts to increase HIV testing, services, and treatment along the continuum. To mee...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Selected Micronutrient Levels and Response to Highly Active Antiretroviral Therapy (HAART) Among HIV/AIDS Patients Attending a Teaching Hospital in Addis Ababa, Ethiopia.
The objective of the study was to determine the association of micronutrient levels and response to HAART (CD4(+) T cell count) among adult HIV/AIDS patients attending a teaching Hospital in Addis Ababa. CD4(+) T cell counts and micronutrient (retinol, zinc, and iron) levels for 171 subjects were determined using standard procedures. Some proportions of the study participants were found deficient for retinol (14.03 %), zinc (47.3 %), and iron (2.8 %). Patients who were deficient in retinol had a significantly lower median CD4(+) T cell counts (P?=?0.002) compared to non-deficient subjects. Association of micronutrient quartiles with CD4+ T cell count was assessed using adjusted multivariate regression by taking quartile 4 as a reference category. Accordingly, patients who had retino...
FDA Approves 2 HIV-1 Cocktail DrugsFDA Approves 2 HIV-1 Cocktail Drugs
Elvitegravir (Vitekta) is an integrase inhibitor; cobicistat (Tybost) boosts blood levels of 2 protease inhibitors. FDA Approvals (Source: Medscape Medical News Headlines)
Half of HIV-Positive Gay Men in U.S. Aren?t Getting Proper Treatment
CDC report recommends greater effort to boost HIV testing and retain patients in care (Source: Fertility News - Doctors Lounge)
Retention in Care and Adherence to ART are Critical Elements of HIV Care Interventions
Abstract Retention in care and adherence to antiretroviral treatment (ART) are critical elements of HIV care interventions and are closely associated with optimal individual and public health outcomes and cost effectiveness. This literature review was conducted to analyse how the roles of clients in HIV care and treatment are discussed, from terminology used to measurement methods to consequences of a wide range of patient-related factors impacting client adherence to ART and retention in care. Unfortunately, data suggests that clients find it hard to follow recommended behaviour. For HIV, the greatest loss to follow-up occurs before starting treatment, though each step of the continuum of care is affected. Measurement approaches can be divided into ?direct? and ?indire...
Effectiveness of HIV Prevention for Women: What Is Working?
This study provides new evidence related to HIV prevention. Particularly, the higher efficacy of motivational components for these young Spanish women is revealed. (Source: AIDS and Behavior)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Socialization Patterns and Their Associations with Unprotected Anal Intercourse, HIV, and Syphilis Among High-Risk Men Who Have Sex with Men and Transgender Women in Peru
Abstract The association of socialization patterns with unprotected anal intercourse (UAI) and HIV/STI prevalence remains underexplored in men who have sex with men (MSM) and transgender women (TW) in developing country settings. We evaluated the correlation of UAI, HIV, and syphilis with MSM/TW venue attendance and social network size among high-risk MSM and TW in Peru according to self-reported sexual identity. Frequency of venue attendance and MSM/TW social network size were lowest among heterosexual MSM and highest among TW respondents. Attendance (frequent or occasional) at MSM/TW venues was associated with increased odds of insertive UAI among heterosexual participants. Frequent venue attendance was associated with increased odds of receptive UAI among gay/homosexual, bisex...
HIV Prevalence and Risk Behaviours Among Foreign Migrant Women Residing in Cape Town, South Africa
Abstract HIV prevalence and risk behaviour among foreign migrants in South Africa has not been explored. This paper describes the effectiveness of respondent-driven sampling (RDS) to recruit foreign migrant women residing in Cape Town, reports HIV prevalence, and describes key characteristics among them. We conducted a biological and behavioural surveillance survey using RDS. After written informed consent, participants completed an audio computer assisted self-interview and provided a dried blood sample for HIV analysis. HIV prevalence was estimated to be 7 % (CI 4.9?9.5) among 935 women. HIV sero-positivity was associated with older age (p = 0.001), country of origin (p &lt; 0.000), being unmarried (p &lt; 0.000), having lived in South Africa for 3?5 years (p = 0.0...
Condoms Used But Sex Not Well Protected
Abstract Condom use is often equated to safer sex. The prevalence of condom use during sex work among female sex workers (FSW) in China is high. Condom use, however, co-exists with condom failure and improper use and hence risk of HIV transmission. In a cross-sectional study, we interviewed 195 FSW in Shenzhen, China. The prevalence of condom use in the last episode of sex work was 97.4 %, However, respectively 53.8 and 86.2 % had experienced at least one condition of condom failure that may lead to genital contact (wearing condoms after penetration, condom breakage/slippage, condoms removed by clients) and at least one condition of improper condom use (not removing air from the tip of the condom, not pulling it down to the root of penis and not choosing good quality condoms). ...
Chlamydia Prevalence and Associated Behaviours Among Female Sex Workers in Vanuatu: Results from an Integrated Bio-behavioural Survey, 2011
Abstract There is insufficient data on sexually transmitted infections (STI) and related behaviours among key populations, including female sex workers (FSW), in the Pacific region. Using respondent driven sampling, we conducted an integrated bio-behavioural survey with FSW in Vanuatu (aged ?18 years) to investigate risk behaviours associations with Chlamydia trachomatis (CT). Weighted population estimates and correlates of CT infection were calculated. Among 149 FSW, prevalence of CT was 36 % (95 % CI 26?48 %). Few FSW reported consistent condom use with recent transactional sex partners (TSP) (8 %; 95 % CI 2?13 %). CT infection was positively associated with increasing number of TSP (adjusted odds ratio [AOR] 1.1; 95 % CI 1.0?1.2) and group sex (AOR 2.9; 95 % C...
A Review of the Role of Food Insecurity in Adherence to Care and Treatment Among Adult and Pediatric Populations Living with HIV and AIDS
Abstract Adherence to antiretroviral therapy (ART) is critical for reducing HIV/AIDS morbidity and mortality. Food insecurity (FI) is emerging as an important barrier to adherence to care and treatment recommendations for people living with HIV (PLHIV), but this relationship has not been comprehensively examined. Therefore, we reviewed the literature to explore how FI may impact ART adherence, retention in medical care, and adherence to health care recommendations among PLHIV. We found data to support FI as a critical barrier to adherence to ART and to other health care recommendations among HIV-infected adults, HIV-infected pregnant women and their HIV-exposed infants, and child and adolescent populations of PLHIV. Associations between FI and ART non-adherence were seen in quali...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Alcohol and Sexual Risk Reduction Interventions Among People Living in Russia: A Systematic Review and Meta-analysis
Abstract Russia has one of the highest rates of alcohol consumption and is experiencing one of the fastest-growing HIV epidemics in the world. Given these co-occurring health problems, we systematically reviewed combined alcohol and sexual risk interventions to reduce HIV among Russians. We completed comprehensive electronic searches to locate studies that (a) sampled people living in Russia, (b) used a behavioral intervention, and (c) assessed both alcohol and sexual risk behavior. These searches yielded 584 studies, of these, two were included. Compared with controls, intervention participants reported increasing their condom use (ds ranged from 0.12 to 0.85). Within-group improvements in sexual behaviors were found for both groups (ds ranged from 0.19 to 1.94); participants re...
Economic and Social Factors are Some of the Most Common Barriers Preventing Women from Accessing Maternal and Newborn Child Health (MNCH) and Prevention of Mother-to-Child Transmission (PMTCT) Services: A Literature Review
Abstract Support to health programming has increasingly placed an emphasis on health systems strengthening. Integration of prevention of mother-to-child transmission (PMTCT) and maternal and newborn child health (MNCH) services has been one of the areas where there has been a shift from a siloed to a more integrated approach. The scale-up of anti-retroviral therapy has made services increasingly available while also bringing them closer to those in need. However, addressing supply side issues around the availability and quality of care at the health centre level alone cannot guarantee better results without a more explicit focus on access issues. Access to PMTCT care and treatment services is affected by a number of barriers which influence decisions of women to seek care. Th...
The Enabling Effect of Food Assistance in Improving Adherence and/or Treatment Completion for Antiretroviral Therapy and Tuberculosis Treatment: A Literature Review
Abstract Socioeconomic costs of HIV and TB and the difficulty of maintaining optimal treatment are well documented. Social protection measures such as food assistance may be required to offset some of the treatment related costs as well as to ensure food security and maintain good health of the affected individual and household. Programmes have started placing greater emphasis on treatment adherence and are looking for proven interventions that can optimize it. This paper looks at the effect of food assistance for enabling treatment adherence and reviews studies that used food assistance to promote adherence. Eight of ten studies found that provision of food can improve adherence and/or treatment completion for HIV care and treatment, ART and TB-DOTS. This indicates that food pro...
Food Security and Nutrition Interventions in Response to the Aids Epidemic: Assessing Global Action and Evidence
Abstract The number of people receiving antiretroviral therapy in developing countries has increased dramatically. The last decade has brought an increased understanding of the interconnectedness between HIV/AIDS, food insecurity, and undernutrition and a surge of evidence on how to address the food security and nutrition dimensions of the epidemic. We review this evidence as well as the corresponding evolution of policy support for incorporating food security and nutrition concerns into HIV programming. The available evidence, although varied in scope and methodologies, shows that nutrition supplementation and safety nets in the form of food assistance and livelihood interventions have potential in certain contexts to improve food security and nutrition outcomes in an HIV/AI...
Tailored Nutrition Education and Food Assistance Improve Adherence to HIV Antiretroviral Therapy: Evidence from Honduras
We examined the effect of providing household food assistance and nutrition education on ART adherence. A 12-month prospective clinical trial compared the effect of a monthly household food basket (FB) plus nutrition education (NE) versus NE alone on ART adherence on 400 HIV patients at four clinics in Honduras. Participants had been receiving ART for an average of 3.7 years and were selected because they had suboptimal adherence. Primary outcome measures were missed clinic appointments, delayed prescription refills, and self-reported missed doses of ART. These three adherence measures improved for both groups over 12 months (p &lt; 0.01), mostly within 6 months. On-time prescription refills improved for the FB plus NE group by 19.6 % more than the group receiving NE alone after 6 m...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Socially-Integrated Transdisciplinary HIV Prevention
This article presents a framework for socially-integrated transdisciplinary HIV prevention that may improve current prevention efforts. It first describes one socially-integrated transdisciplinary intervention project, the Transmission Reduction Intervention Project. We focus on how social aspects of the intervention integrate its component parts across disciplines and processes at different levels of analysis. We then present socially-integrated perspectives about how to improve combination antiretroviral treatment (cART) processes at the population level in order to solve the problems of the treatment cascade and make ?treatment as prevention? more effective. Finally, we discuss some remaining problems and issues in such a social transdisciplinary intervention in the hope that other ...
Cost-Effectiveness of Interventions to Prevent HIV and STDs Among Women: A Randomized Controlled Trial
This study assesses cost-effectiveness of behavioral interventions for reducing HIV and STDs infections among injection drug-using women. Cost-effectiveness analysis was conducted from societal and provider perspectives for randomized trial data and Bernoullian model estimates of infections averted for three increasingly intensive interventions: (1) NIDA?s standard intervention (SI); (2) SI plus a well woman exam (WWE); and (3) SI, WWE, plus four educational sessions (4ES). Trial results indicate that 4ES was cost-effective relative to WWE, which was dominated by SI, for most diseases. Model estimates, however, suggest that WWE was cost-effective relative to SI and dominated 4ES for all diseases. Trial and model results agree that WWE is cost-effective relative to SI per hepatitis C infe...
Food Security in the Context of HIV: Towards Harmonized Definitions and Indicators
Abstract Integration of HIV and food security services is imperative to improving the health and well-being of people living with HIV. However, consensus does not exist on definitions and measures of food security to guide service delivery and evaluation in the context of HIV. This paper reviews definitions and indicators of food security used by key agencies; outlines their relevance in the context of HIV; highlights opportunities for harmonized monitoring and evaluation indicators; and discusses promising developments in data collection and management. In addition to the commonly used dimensions of food availability, access, utilization and stability, we identify three components of food security?food sufficiency, dietary quality, and food safety?that are useful for underst...
A Mixed-Methods Study of Condom Use and Decision Making Among Adolescent Gay and Bisexual Males
Abstract Young men who have sex with men have the highest rates of new HIV infections in the U.S., but they have been understudied relative to other populations. As a formative step for the development of a text messaging HIV prevention intervention, this mixed methods study aimed to understand how adolescent gay and bisexual males (AGBM) make decisions about condom use and factors that may differ based on age, sexual experience, and rural versus urban residency. Four online, asynchronous focus groups were conducted with 75 14?18 year old AGBM across the U.S. Qualitative analyses uncovered themes related to relationship influences on condom use (e.g. marriage, trust), access issues, and attitudes and experiences that both encouraged as well as discouraged condom use. Mixed met...
Where Does Treatment Optimism Fit in? Examining Factors Associated with Consistent Condom Use Among People Receiving Antiretroviral Treatment in Rio de Janeiro, Brazil
Abstract In the era of highly active antiretrovirals, people living with HIV (PLWH) have resumed sexual activity in the context of longer and healthier lives, and thus the chances of transmitting the HIV virus, as well as the potential to be re-infected also increase. HIV treatment optimism has been found to be associated with sexual risk behaviors among PLWH in different settings. A cross sectional survey was conducted to examine the relationship between treatment optimism, safer sex burnout and consistent condom use as well as variables associated with treatment optimism in a sample of PLWH on antiretrovirals (ARVs) in Rio de Janeiro, Brazil (n = 604). Seventy-two percent of participants always used a condom in the last 6 months. Homosexual, bisexual, transexual persons were...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Sexual Partner Notification of HIV Infection Among a National United States-Based Sample of HIV-Infected Men
We examined factors associated with complete (all partners) versus incomplete partner notification in 760 HIV-infected individuals across the United States, 49 % of whom were MSM. Thirty-four percent reported incomplete partner notification. Incomplete partner notification was more likely among black men, MSM, and those reporting casual partners and non-condom use. Partner notification practices did not vary by HIV viral load except among those with casual partners in whom a detectable viral load was associated with incomplete partner notification. Increased sexual partner notification among HIV-infected men, especially MSM, is needed. (Source: AIDS and Behavior)
Adherence to HIV and TB Care and Treatment, the Role of Food Security and Nutrition
Abstract Food security and nutrition play an important role in HIV and TB care and treatment, including for improving treatment outcomes, adherence and uptake of HIV and TB care. This AIDS and behaviour supplement on ?Adherence to HIV and TB care and treatment, the role of food security and nutrition? provides an overview of the current evidence and knowledge about the barriers to uptake and retention in HIV and TB treatment and care and on whether and how food and nutrition assistance can help overcome these barriers. It contains nine papers on three topic areas discussing: (a) adherence and food and nutrition security in context of HIV and TB, their definitions, measurement tools and the current situation; (b) food and nutrition insecurity as barriers to uptake and retentio...
Protective Factors and HIV Risk Behavior Among South African Men
Abstract The primary mode of HIV transmission in South Africa is heterosexual sexual behavior. HIV prevention research specifically focusing on men in South Africa is limited. We assessed self-reported HIV risk behaviors in 1,181 men ages 18 to 45 years in randomly selected neighborhoods in Eastern Cape Province, South Africa. Older men were less likely to report having multiple partners. Religiosity was a protective factor for condom use and unprotected sex with steady partners. Discussing using condoms was a protective factor for condom use and unprotected sex with both steady and casual partners. Having a child was associated with decreased condom use with steady partners and employment was associated with decreased condom use with casual partners. The findings suggest the ne...
Anxiety Disorders in Older Adults
Abstract Late life anxiety disorders are the most prevalent psychiatric conditions among older adults and they often present at a sub-threshold level. Specific phobias (SP) are particularly frequent and fear of falling is increasingly being recognized as a class of phobias typically seen in older adults. Generalized anxiety disorder (GAD), although recognized as a chronic disorder with early onset, has been found to have an onset late in life as well. Social phobia (SoP) has been found to not necessarily have a chronic course in this population. Post-traumatic stress disorder (PTSD) manifests in older adults often as an exacerbation of symptoms from a trauma earlier in life. Cognitive behavior therapy (CBT) augmented with learning and memory aids, and a combination of CBT and medi...
Digital Tools Unveiled to Improve Doctor-Patient InteractionDigital Tools Unveiled to Improve Doctor-Patient Interaction
Technology companies are promoting a panoply of new software programs to help patients and physicians communicate. Medscape Medical News (Source: Medscape Hiv-Aids Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Stem cell transplant does not cure SHIV/AIDS after irradiation of infected rhesus macaques
A new primate model has been developed to test treatments that might cure HIV/AIDS and suggests answers to questions raised by the 'Berlin patient,' the only human thought to have been cured so far. (Source: ScienceDaily Headlines)
The Effect of the Different Treatment Protocols on Virological and Immunological Responses in Patients with HIV/AIDS.
This study analyzed the differences between the virological and immunological responses in patients with HIV/AIDS subjected to different treatment protocols. The cases treated with HAART were divided into groups on the basis of treatment protocols. The groups were evaluated with respect to the differences by comparing the virological and immunological responses prior to treatment and at 12 and 24 weeks of therapy. Six different treatment protocols were applied in the treated patients. As the largest clusters, the lopinavir/ritonavir-based patient group (Group 1, n = 29) and efavirenz-based patient group (Group 2, n = 18) were compared. The mean CD4 and HIV-RNA values of Groups 1 and 2 were 184 and 243 h/?l and 422,266 and 317,684 copies/ml, respectively. At 24 weeks of treatment, the HIV-...
Nasally located ectopic ACTH-secreting pituitary adenoma (EAPA) causing Nelson?s syndrome: diagnostic challenges
Conclusion Ectopic ACTH-secreting pituitary adenomas can occur not only along the developmental route of Rathke?s pouch, but other aberrant locations giving a clinical and biochemical picture identical to Cushing?s disease or Nelson?s syndrome. Clinicians should suspect an EAPA, when a central ACTH source seems to be apparent with no obvious pituitary adenoma. A detailed MRI involving possible EAPA sites aids in locating these unusual lesions. (Source: Pituitary)
HIV and Gay and Bisexual Men Infographic
This infographic provides data on HIV infection and medical care for gay and bisexual men, and includes HIV prevention information. (Source: CDC HIV/AIDS Prevention)
Half of HIV-Positive Gay Men in U.S. Aren't Getting Proper Treatment
CDC report recommends greater effort to boost HIV testing and retain patients in care Source: HealthDay Related MedlinePlus Pages: Gay, Lesbian, Bisexual and Transgender Health, HIV/AIDS, HIV/AIDS Medicines (Source: MedlinePlus Health News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Fashion designer Victoria Beckham joins UN effort to achieve world free of HIV
The Joint United Nations Programme on HIV/AIDS (UNAIDS) today appointed British fashion designer Victoria Beckham as its International Goodwill Ambassador, with a focus on women and children affected by the virus. (Source: UN News Centre - Health, Poverty, Food Security)
UNAIDS appoints Victoria Beckham goodwill ambassador
UNITED NATIONS (Reuters) - The United Nations program on HIV/AIDS (UNAIDS) on Thursday named fashion designer and former Spice Girl Victoria Beckham a goodwill ambassador. (Source: Reuters: Health)
Unmet Needs in Autoimmunity and Potential New Tools
Abstract The term ?autoimmunity? refers to a pathological condition in which the immunological tolerance of self-antigens is broken through, cross-reactive T cells are activated, and autoantibodies are produced by B cells. The intricate interplay among those aberrantly activated immune cells as well as inflammatory cytokines secreted by them contributes to the development of proinflammatory cascade which eventually leads to the occurrence of autoimmune diseases (AIDs) and organ damage. Autoimmune diseases occupy a broad spectrum of human diseases with more than 70 different disorders and afflict approximately 5?8 % of the world?s population. AIDs can be categorized into organ-specific and systemic. Although the exact mechanism of AIDs remains elusive, it is generally bel...
Food insecurity and antiretroviral adherence among HIV positive adults who drink alcohol
Abstract Food insecurity is associated with HIV treatment non-adherence and poor health outcomes for people living with HIV/AIDS. Given the poor nutritional status common to people who drink alcohol, food insecurity may be particularly problematic for HIV positive individuals who drink alcohol. To examine food insecurity among HIV positive men and women who drink alcohol and its association with antiretroviral therapy (ART) adherence, health outcomes and health service utilization. Adults living with HIV (N = 183) in Atlanta, Georgia who reported alcohol use in the previous week and were receiving ART participated in a 12-month cohort. Participants were recruited from infectious disease clinics and social services to complete computerized interviews, monthly-unannounced pill co...
Positive and negative religious coping, depressive symptoms, and quality of life in people with HIV
Abstract The present study examined the relationships of positive and negative types of religious coping with depression and quality of life, and the mediating role of benefit finding in the link between religious coping and psychological outcomes among 198 individuals with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS). The results of multiple hierarchical analyses revealed that negative religious coping was significantly associated with a high level of depressive symptoms and a low level of quality of life, controlling for demographic and clinical variables. On the other hand, positive religious coping was significantly associated with positive domains of outcome measures such as positive affect and life satisfaction, but not with overall depressiv...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
High prevalence and incidence of sexually transmitted infections among women living in Kwazulu-Natal, South Africa.
CONCLUSIONS: These results confirm the extremely high prevalence and incidence of STIs among women living in rural and urban communities of KwaZulu-Natal, South Africa, where the HIV epidemic is also particularly severe. These findings strongly suggest an urgent need to allocate resources for STI and HIV prevention that mainly target younger women. TRIAL REGISTRATION: Clinical Trials.gov, NCT00121459. PMID: 25243015 [PubMed] (Source: AIDS Research and Therapy)
Greater frequency of CD5-negative CD8(+) T cells against human immunodeficiency virus type 1 than other viruses is consistent with adaptation to antigenic variation.
CONCLUSIONS: This deficit in CD5 expression selective for HIV-specific CD8(+) T cells is consistent with in vivo adaptation to low avidity HIV peptide variants and has potential consequences for CD8(+) T cell expansion, cross-reactivity and autoreactivity. PMID: 25237383 [PubMed] (Source: AIDS Research and Therapy)
Nigeria: Nigerians Urged to Embrace HIV/Aids Victims
[Daily Independent]Senior faith leaders on HIV/AIDS drawn from some local government areas in Lagos state have emphasized the need to exhibit love and eschew bitterness when relating with the victims. (Source: AllAfrica News: HIV-Aids and STDs)
Our T-cells have been hiding something: Another way to kill bacteria
We report and comment on medical innovations and advances ? from bench to bedside ? touching on scientific, business and policy issues. Our ranks include science writers, physicians, lab researchers, market analysts and others inside and outside the hospital. Listeria bacteria on a plate. The biology of HIV/AIDS suggests T-cells have a hitherto unrecognized way of killing pathogens like these. By Tom Ulrich The immune system, despite its immense complexity, really has only a few ways to kill bacteria: Boston Children&#039;s HospitalNews Well, Vector Blog, Big Data, Blogread more (Source: Mass Device)
Nigeria: Donor Aid for HIV Drying Up, Nigeria Must Step Up Local Funding, Says Agency
[Guardian]Dr. Bilali Camara is the Joint United Nations Programme on HIV/ AIDS (UNAIDS) is the Country Director in Nigeria. He is also the UNAIDS Focal Point for the Economic Community of West Africa (ECOWAS). Camara said although the Ebola Virus Diseases has in recent times received great media and public attention, Human Immuno-deficiency Virus (HIV)/Acquired Immune Deficiency Syndrome (AIDS) remains a major heath challenges in Nigeria. Camara spoke to EMEKA ANUFORO about the (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Comprehensive identification of MHC class II alleles in a cohort of Chinese rhesus macaques
Abstract Rhesus macaque is a very important animal model for various human diseases, especially for AIDS and vaccine research. The susceptibility and/or resistance to some of these diseases are related to the major histocompatibility complex (MHC). To gain insight into the MHC background and to facilitate the experimental use of Chinese rhesus macaques, Mamu-DPB1, Mamu-DQB1, and Mamu-DRB alleles were investigated in 30 Chinese rhesus macaques through gene cloning and sequencing. A total of 66 alleles were identified in this study, including 14 Mamu-DPB1, 20 Mamu-DQB1, and 30 Mamu-DRB alleles as well as 2 high-frequency Mamu-DPB1 alleles. Interestingly, one of the high-frequency Mamu-DPB1 alleles had been undocumented in earlier studies. Eleven of the other alleles, including four...
Liberia: Aids, TB Patients Not Forgotten During Liberia's Ebola Crisis
[VOA]Dakar -With health clinics closed and people afraid to come in for treatment, Liberia's national AIDS commission says they are now going door-to-door to get people to come take their antiretroviral medications. All eyes are on Ebola, but experts say there are other deadly diseases being overlooked in the crisis. (Source: AllAfrica News: Health and Medicine)
Piceatannol aids weight management, helps prevent obesity, found in red grapes and wine
(NaturalNews) Obesity is threatening the health and lives of nearly 70 percent of the U.S. population, and indicators of this epidemic are continuing to affect even more men, women and children and place a significant burden on an already failing health care system. Most health-minded... (Source: NaturalNews.com)
Stem cell transplant does not cure SHIV/AIDS after irradiation of infected rhesus macaques
(PLOS) A study published on Sept. 25 in PLOS Pathogens reports a new primate model to test treatments that might cure HIV/AIDS and suggests answers to questions raised by the 'Berlin patient,' the only human thought to have been cured so far. (Source: EurekAlert! - Infectious and Emerging Diseases)
On the margins of aid orthodoxy: the Brazil-Mozambique collaboration to produce essential medicines in Africa
DiscussionWe show that the project process has been very long and complex, has involved multiple public and private partners, and cost in excess of USD34 million. There have also been setbacks in the process, and although production has already started, it is unclear whether all the project?s original objectives will be met.SummaryThe Brazil-Mozambique?s pharmaceutical factory experience illustrates positives as well as limitations of Brazil?s unorthodox approach to health development cooperation, highlighting its contribution to pushing the boundaries of the debate on local production of pharmaceuticals in resource-poor settings. (Source: Globalization and Health)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
HIV in Hiding [Video] - The 64th Annual Lindau Meeting
Can someone be cured of the AIDS virus? Nature Video examined this question during this summer's Lindau Nobel Laureate Meeting, which brought early-career biologists together with Nobel... -- Read more on ScientificAmerican.com (Source: Scientific American - Official RSS Feed)
The importance of monocytes and macrophages in HIV pathogenesis, treatment, and cure
This article examines the importance of monocyte subsets and tissue macrophages in HIV pathogenesis. Additionally, we will review the role of monocytes and macrophages in the development of serious non-AIDS events including cardiovascular disease and neurocognitive impairment, their significance in viral persistence, and how these cells represent an important obstacle to achieving HIV eradication. (Source: AIDS)
Surface-bound Tat inhibits antigen-specific CD8+ T-cell activation in an integrin-dependent manner
Conclusion:Our results support the idea that CD8+ T-cell apoptosis induced by surface-bound extracellular Tat can contribute to the dysregulation of the CD8+ T-cell adaptive response against HIV as well as other pathogens present in AIDS patients. (Source: AIDS)
Deficient synthesis of class-switched, HIV-neutralizing antibodies to the CD4 binding site and correction by electrophilic gp120 immunogen
Conclusion:A CLIN-selective physiological defect of IgM?IgG class-switch recombination (CSR) or restricted post-CSR B-cell development limits the functional utility of the humoral immune response to gp120. The E-gp120 immunogen is useful to bypass the restriction and induce broadly neutralizing CLIN-directed IgGs (see Supplemental Video Abstract, http://links.lww.com/QAD/A551). (Source: AIDS)
Palbociclib, a selective inhibitor of cyclin-dependent kinase4/6, blocks HIV-1 reverse transcription through the control of sterile ? motif and HD domain-containing protein-1 (SAMHD1) activity
Conclusions:Our results indicate that SAMHD1-mediated HIV-1 restriction is controlled by CDK as previously suggested but point to a preferential role for CDK2 and CDK6 as mediators of SAMHD1 activation. Our study provides a new signaling pathway susceptible for the development of new therapeutic approaches against HIV-1 infection. (Source: AIDS)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Comparison of auditory brainstem response in HIV-1 exposed and unexposed newborns and correlation with the maternal viral load and CD4+ cell counts
Conclusion:There was a trend towards more hearing loss in HIV-exposed newborns. However, hearing thresholds increase with increasing mothers? viral load. The background information supports the need for further studies on the role of in-utero exposure to HIV and HAART in newborn hearing loss. (Source: AIDS)
Limited clinical benefit of minority K103N and Y181C-variant detection in addition to routine genotypic resistance testing in antiretroviral therapy-naive patients
Conclusion:As revealed in settings of case?control studies, minority NNRTI-resistant HIV-1 variants can have an impact on ART. However, the implementation of minority NNRTI-resistant HIV-1 variant analysis in addition to genotypic resistance testing (GRT) cannot be recommended in routine clinical settings. Additional associated risk factors need to be discovered. (Source: AIDS)
Successful antiretroviral therapy delivery and retention in care among asymptomatic individuals with high CD4+ T-cell counts above 350 cells/?l in rural Uganda
Conclusions:We demonstrate high virologic suppression, retention, and safety among asymptomatic individuals with CD4+ above 350 cells/?l in a prototypic Ugandan clinic. Our results challenge current concerns that individuals with high CD4+ cell count lack motivation for ART, and may not achieve sustained virologic suppression. (Source: AIDS)
Low levels of HIV-1 RNA detected in the cerebrospinal fluid after up to 10 years of suppressive therapy are associated with local immune activation
We examined the frequency and magnitude of persistent low-level HIV-1 RNA in CSF and its relation to the central nervous system (CNS) immune activation. Methods:CSF and plasma HIV-1 RNA were measured using the single-copy assay with a detection limit of 0.3 copies/ml in 70 CSF and 68 plasma samples from 45 treated HIV-1-infected patients with less than 40 copies/ml of HIV-1 RNA in both fluids by standard clinical assays. We also measured CSF neopterin to assess intrathecal immune activation. Theoretical drug exposure was estimated using the CNS penetration-efficacy score of treatment regimens. Results:CSF HIV-1 RNA was detected in 12 of the 70 CSF samples (17%) taken after up to 10 years of suppressive therapy, compared to 39 of the 68 plasma samples (57%) with a median concentration of le...
Pregnancy outcomes and birth defects from an antiretroviral drug safety study of women in South Africa and Zambia
Objective:To evaluate the safety of combination antiretroviral therapy (ART) in conception and pregnancy in different health systems. Design:A pilot ART registry to measure the prevalence of birth defects and adverse pregnancy outcomes in South Africa and Zambia. Methods:HIV-infected pregnant women on ART prior to conception were enrolled until delivery, and their infants were followed until 1 year old. Results:Between October 2010 and April 2011, 600 women were enrolled. The median CD4+ cell count at study enrollment was lower in South Africa than Zambia (320 vs. 430?cells/?l; P? (Source: AIDS)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Simplification to atazanavir/ritonavir monotherapy for HIV-1 treated individuals on virological suppression: 48-week efficacy and safety results
Conclusion:ATV/r monotherapy treatment simplification showed lower virological efficacy in comparison with maintaining triple therapy; NRTIs reintroduction was effective in all the individuals. (Source: AIDS)
HIV-1 superinfection is associated with an accelerated viral load increase but has a limited impact on disease progression
Objective:HIV-1 superinfection occurs frequently in high-risk populations, but its clinical consequences remain poorly characterized. We undertook this study to determine the impact of HIV-1 superinfection on disease progression. Design/methods:In the largest prospective cohort study of superinfection to date, we compared measures of HIV-1 progression in women who acquired superinfection with those who did not. Clinical and laboratory data were collected at quarterly intervals. Linear mixed effects models were used to compare postacute viral load and CD4+ T-cell counts over time in singly infected and superinfected women. Cox proportional hazards analysis was used to determine the effect of superinfection on time to clinical progression [CD4+ cell count (Source: AIDS)
High-risk enteric pathogens associated with HIV infection and HIV exposure in Kenyan children with acute diarrhoea
Conclusion:EPEC and Cryptosporidium infections were more common in HIV-infected and HIV-exposed children, respectively. This could explain the increased mortality attributed to these pathogens in other studies. Interventions targeting EPEC and Cryptosporidium may reduce morbidity and mortality in high HIV-prevalence settings. (Source: AIDS)
Delayed HIV diagnosis and initiation of antiretroviral therapy: inequalities by educational level, COHERE in EuroCoord
We examined trends by education level in presentation with advanced HIV disease (AHD) (CD4+ (Source: AIDS)
Texting improves testing: a randomized trial of two-way SMS to increase postpartum prevention of mother-to-child transmission retention and infant HIV testing
Conclusions:Text messaging significantly improved maternal postpartum visit attendance, but overall return rates for these visits remained low. In contrast, high rates of early infant HIV testing were achieved in both arms, with significantly higher testing rates in the SMS compared to the control infants. (Source: AIDS)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Risk of non-Hodgkin lymphoma subtypes in HIV-infected people during the HAART era: a population-based study
Conclusion:HIV-infected people in the HAART era continue to have elevated risk of AIDS-defining NHL subtypes, highlighting the contribution of moderate and severe immunosuppression to their cause. Whereas non-AIDS-defining subtypes are much less common, immunosuppression or other dysregulated immune states likely play a role in the cause of some T-cell lymphomas, marginal zone lymphoma, lymphoplasmacytic lymphoma/Waldenström macroglobulinemia, and acute lymphoblastic leukemia/lymphoma. (Source: AIDS)
Novel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients
A novel tetra-peptide insertion was identified in Gag-p6 ALIX-binding region, which appeared in protease inhibitor failure Indian HIV-1C sequences (odds ratio=17.1, P? (Source: AIDS)
HLA-B?35-PX and HLA-B?35-PY subtype differentiation does not predict observed differences in level of HIV control in a Peruvian MSM cohort
No abstract available (Source: AIDS)
Ending the invisibility of sex workers in the US HIV/AIDS surveillance and prevention strategy
No abstract available (Source: AIDS)
Triple secondary neoplasms: penis, lip and oral cavity in an AIDS patient treated with pegylated liposomal doxorubicin for cutaneous Kaposi's sarcoma
No abstract available (Source: AIDS)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Virological and immunological outcomes of elvitegravir-based regimen in a treatment-naïve HIV-2-infected patient
No abstract available (Source: AIDS)
Etravirine and rilpivirine-specific mutations selected by efavirenz and nevirapine exposure in patients infected with HIV-1 non-B subtypes
No abstract available (Source: AIDS)
Malawi: UN - First Lady Calls for Inclusion of Youths in Matters Affecting Their Lives
[Malawi News Agency]New York -: Malawi's First Lady, Madam Getrude Mutharika has called on member states of the Eastern and Southern Africa (ESA Initiative) to fully involve the youth in matters that affect their lives and promote peer education among them to avoid early pregnancies, marriages and HIV infections. (Source: AllAfrica News: HIV-Aids and STDs)
Chronic Binge Alcohol Consumption Does Not Diminish Effectiveness of Continuous Antiretroviral Suppression of Viral Load in Simian Immunodeficiency Virus?Infected Macaques
ConclusionsThese findings indicate that CBA does not attenuate effectiveness of NRTI suppression of viral load, nor does it appear to interact with NRTI to produce toxicity during the initial 2 months of treatment. We conclude that while efforts to reduce AUD in PLWHA should be a priority, counseling on the importance of adherence to ART even on drinking days should also be promoted. (Source: Alcoholism: Clinical and Experimental Research)
Modeling the Implementation of Universal Coverage for HIV Treatment as Prevention and its Impact on the HIV Epidemic
Abstract The Joint United Nations Programme on HIV/AIDS (UNAIDS) recently updated its global targets for antiretroviral therapy (ART) coverage for HIV-positive persons under which 90 % of HIV-positive people are tested, 90 % of those are on ART, and 90 % of those achieve viral suppression. Treatment policy is moving toward treating all HIV-infected persons regardless of CD4 cell count?otherwise known as treatment as prevention?in order to realize the full therapeutic and preventive benefits of ART. Mathematical models have played an important role in guiding the development of these policies by projecting long-term health impacts and cost-effectiveness. To guide future policy, new mathematical models must consider the barriers patients face in receiving and taking ART. Here...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Communication intervention in Rett syndrome: a survey of speech language pathologists in Swedish health services.
Conclusions: Communication aids were reported to have a positive influence on communicative functions. Swedish SLP services followed best practice in several aspects, but there are areas with potential for development. Tools and best practice guidelines are needed to support SLPs in the AAC process for clients with Rett syndrome. [Box: see text]. PMID: 25250808 [PubMed - as supplied by publisher] (Source: Disability and Rehabilitation)
3in * a lifetime in paradise
Although the global burden of cancer is not known with precision, it is certain that it has doubled over the last 25 years and is set to double again before 2030. This period has also witnessed unprecedented advances in knowledge of Oncology from understanding causes, both lifestyle and biological, to the enormous progress in developing effective treatments for many forms of cancer.However, the contrast in diagnosis, treatment and outcomes between the high-resource and low-resource countries is dramatic. This is a particularly important issue since the pattern of cancer globally in the foreseeable future will be heavily dependent on what happens in China, India and Africa, where half of the world's population currently live. Africa presents the biggest challenge with population growth and ...
549p * impact of tumour ras/braf status on efficacy of first-line panitumumab + folfiri in patients (pts) with metastatic colorectal cancer (mcrc)
Conclusions: In line with recent studies, consistently favourable efficacy was observed in pts with RAS/BRAF WT vs MT mCRC tumours receiving first-line panitumumab + FOLFIRI treatment. KRAS mutation status appears insufficient for selecting pts for first-line panitumumab + FOLFIRI treatment; tumour RAS analysis aids optimum pt selection.Disclosure: M. Karthaus: Prof Karthaus has participated in Advisory boards (compensated) for Amgen; L. Mineur: has received research support from Amgen (but not in the context of this abstract), honoraria from Amgen for participation in advisory boards (but not for this study); R. Greil: has received honoraria from Amgen for participation in advisory boards and research support from Amgen (but not in the context of this abstract); J. Thaler: has received ho...
1403p * hepatitis b and c and human immunodeficiency virus infection in a cohort of patients with cervical cancer from the brazilian national cancer institute
Conclusions: Although the low prevalence of HIV infection, and hepatitis B and C in the cohort analyzed, the possibility of such co-infections should always be evaluated, since those diseases share routes of transmisson and prognosis could be influenced.Disclosure: All authors have declared no conflicts of interest. (Source: Annals of Oncology)
1567p * a multi-institutional surveillance of clinicopathological features and molecular epidemiology of egfr mutations in lung cancer patients living with human immunodeficiency virus infection in japan
Conclusions: There appear to be ethnic differences in the prevalence of EGFR mutations even in the population living with HIV and the clinical characteristics or outcome may be provided in the regional differences.Disclosure: All authors have declared no conflicts of interest. (Source: Annals of Oncology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Kenya: HIV-Aids, Nile Perch and Water Hyacinth
[The Star]In the 5th century BC, Greek historian Herodotus declared Egypt the gift of the Nile. For nearly 2,000 years the source of the Nile remained a mystery. (Source: AllAfrica News: HIV-Aids and STDs)
South Africa: Has President Zuma Hurt Aids Fight More Than Thabo Mbeki?
[Africa Check]Has South African president Jacob Zuma set back the the fight against HIV/AIDS more than his predecessor? Opposition leader Helen Zille believes so but the evidence shows otherwise. (Source: AllAfrica News: Health and Medicine)
Hearing aid charging opposed in feedback exercise
FINANCE: North Staffordshire Clinical Commissioning Group has revealed overwhelming public opposition to its proposals to restrict funding for hearing aids. However, the CCG claimed that much of the evidence cited by a national charity opposing the plans ?lacked relevance?. (Source: HSJ)
Nigeria: HIV/Aids - Rivers Identifies Orphans, Vulnerable Children for Assistance
[Guardian]THE Rivers State government on Monday said it was conducting an "organised survey" to identify orphans and vulnerable children in the state to enable it provide them with necessary assistance. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: Falling HIV Funds Leaves 1.2 Million Vulnerable
[Daily Trust]Continued shortfall in donor funding for HIV/AIDS programme could leave as many as 1.2 million people affected by HIV/AIDS vulnerable as domestic funding from the Nigerian government continues to dwindle. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Table of Contents
Abstract Analysis: Rise in youth suicide attempts followed FDA's antidepressant warnings Study: No major risk of cardiac defects from antidepressant use in pregnancy Clozapine?induced pulmonary embolism and aspiration pneumonia Mood stabilizer mitigates risk of manic switch in bipolar disorder Varenicline with bupropion helps smoking abstinence in NRT nonresponders Stimulants for ADHD could have protective effect on suicide Antipsychotics cause particular concern in study of adverse event visits Brain malformation more common among SSRI?exposed children Varenicline effectiveness improved in combination with NRT Neurosteroid aids depressive symptoms in patients with bipolar disorder Oxytocin nasal spray ineffective in study examining early psychosis New Drug Applications (Source: The Br...
Compound from hops aids cognitive function in young animals
Xanthohumol, a type of flavonoid found in hops and beer, has been shown in a new study to improve cognitive function in young mice, but not in older animals. The findings are another step toward understanding, and ultimately reducing the degradation of memory that happens with age in many mammalian species, including humans. (Source: ScienceDaily Headlines)
Pulmonary Disease Under-recognized in HIVPulmonary Disease Under-recognized in HIV
Screening for COPD, which is linked to a decreased CD4 count, needs to be improved in the HIV-positive population, researchers report. Medscape Medical News (Source: Medscape Medical News Headlines)
Africa: Beating the virus. Stories about HIV in Zimbabwe
[MSF]Lindani, ZA -Six neighbours from the same village, all of them HIV-positive and stable patients on antiretroviral therapy (ART) - the treatment that manages to keep the virus in check - take turns to go and pick up their medicines: every month, one of them goes to the hospital in everyone's name. This is the essence of the so-called Community ART Groups (CAG), a simple, inexpensive initiative benefiting both members of the group and health facilities, started by Médecins Sans Frontières (MSF) in 2013 in T (Source: AllAfrica News: HIV-Aids and STDs)
Namibia: A Passionate Volunteer for HIV/Aids Education
[New Era]Windhoek -Twenty-eight-year-old Maria Makuni Mandondo who lives and works in Musese, a village about 85 kilometres west of Rundu, is making an impact in the lives of communities in the area. She works as a field officer for the Development Aid from People to People (DAPP) and Total Control of the Epidemic (TCE). (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Tanzania: Tanzania Regions Asked Not to Let Up on Aids
[EA Business]Njombe, Tanzania -Tanzania's regional authorities have been asked to set aside money in their annual strategic plans to curb the spread of the HIV/Aids. (Source: AllAfrica News: HIV-Aids and STDs)
Cholesterol Guidelines Applied to HIV-infected PatientsCholesterol Guidelines Applied to HIV-infected Patients
This article compares recommendations for statins among this high-risk population. AIDS (Source: Medscape Today Headlines)
Zimbabwe: Govt to Scale Up Anti-Retroviral Therapy Services
[Key Correspondents]Zimbabwe's Ministry of Health and Child Care has announced plans to scale up anti-retroviral therapy services by the end of 2014, amid concerns over the current huge deficit. (Source: AllAfrica News: HIV-Aids and STDs)
Compound from hops aids cognitive function in young animals
(Oregon State University) Xanthohumol, a type of flavonoid found in hops and beer, has been shown in a new study to improve cognitive function in young mice, but not in older animals. The findings are another step toward understanding, and ultimately reducing the degradation of memory that happens with age in many mammalian species, including humans. (Source: EurekAlert! - Medicine and Health)
Malawi: Dowa Ready for HTC Week
[Malawi News Agency]Dowa -Dowa district is ready for HIV Testing and Counseling week (HTC)schedule for 22nd to 26th September 2014. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Oral-resident natural Th17 cells and {gamma}{delta} T cells control opportunistic Candida albicans infections
Oropharyngeal candidiasis (OPC) is an opportunistic fungal infection caused by Candida albicans. OPC is frequent in HIV/AIDS, implicating adaptive immunity. Mice are naive to Candida, yet IL-17 is induced within 24 h of infection, and susceptibility is strongly dependent on IL-17R signaling. We sought to identify the source of IL-17 during the early innate response to candidiasis. We show that innate responses to Candida require an intact TCR, as SCID, IL-7R&alpha;&ndash;/&ndash;, and Rag1&ndash;/&ndash; mice were susceptible to OPC, and blockade of TCR signaling by cyclosporine induced susceptibility. Using fate-tracking IL-17 reporter mice, we found that IL-17 is produced within 1&ndash;2 d by tongue-resident populations of T cells and CD3+CD4+CD44hiTCR&beta;+CCR6+ natural Th17 (nTh17) c...
Behavioral Counseling Urged for Teens, Young Adults at Risk for STDs
'Intensive' instruction most effective for curbing dangerous practices, U.S. health experts say (Source: Fertility News - Doctors Lounge)
The Examination of Emotion Dysregulation as a Moderator of Depression and HIV-Relevant Outcome Relations Among an HIV+Sample.
Authors: Brandt CP, Bakhshaie J, Zvolensky MJ, Grover KW, Gonzalez A Abstract The present study examined whether emotion dysregulation moderated the relations between depressive symptoms and HIV symptoms, HIV medication adherence due to medication side effects, avoidant coping, and distress tolerance among people living with HIV/AIDS (PLHA). Participants included 115 PLHA (16.8% female; Mage = 49.70, SD = 8.57). Results indicated that there was a significant interaction between depressive symptoms and emotion dysregulation in relation to HIV symptoms, HIV medication adherence due to medication side effects, avoidant coping, and distress tolerance. The form of the interaction indicated that PLHA experiencing higher depressive symptoms and higher levels of emotion dysregulation r...
Typologies of positive psychotic symptoms in methamphetamine dependence.
CONCLUSION: MAP is a heterogeneous syndrome with positive symptom typologies. SCIENTIFIC SIGNIFICANCE: This study represents the first attempt at identifying typologies of MAP and highlights the potential utility of LCA in future large-scale studies. (Am J Addict 2014;XX:XX-XX). PMID: 25251691 [PubMed - as supplied by publisher] (Source: American Journal on Addictions)
Dental Microscopy Aids Granger Dentist in Restorations
(Source: Medical News (via PRIMEZONE))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Malawi: Nankhumwa Urges People to Go for HIV Test, Condemns Mchenga Wa Satana
[Malawi News Agency]Mchinji -Minister of Information, Tourism and Culture Kondwani Nankhumwa Saturday challenged people in the country to go for HIV test to successfully fight the HIV and AIDS pandemic. (Source: AllAfrica News: Health and Medicine)
Georgia?s Female Drug Addicts Face Double Struggle
By Pavol StracanskyTBILISI, Sep 21 2014 (IPS)Irina was 21 when she first started using drugs. More than 30 years later, having lost her husband, her home and her business to drugs, she is still battling her addiction.But, like almost all female drug addicts in this former Soviet state, she has faced a desperate struggle not only with her drug problem, but with accessing help in the face of institutionalised and systematic discrimination because of her gender.?Georgia?s society is very male-dominated,? she told IPS. ?And this is reflected in the attitudes to drugs. It?s as if it?s OK for men to use drugs but not women. For women, the stigma of drug use is massive. There are many women who do not join programmes helping them as they would rather not be seen there.?Women make up...
WHO calls for stronger focus on adolescent health. Road traffic injuries, HIV/AIDS, suicide are top causes of death; depression is number 1 cause of illness and disability -
[Abstract unavailable] Language: en... (Source: SafetyLit: All (Unduplicated))
Host Defense Against Cryptococcal Disease: Is There a Role for B Cells and Antibody-Mediated Immunity?
We describe what is currently known. (Source: Current Fungal Infection Reports)
Treatment of severe or progressive Kaposi's sarcoma in HIV-infected adults.
CONCLUSIONS: The findings from this review suggest that HAART plus chemotherapy may be beneficial in reducing disease progression compared to HAART alone in patients with severe or progressive Kaposi's sarcoma. For patients on HAART, when choosing from different chemotherapy regimens, there was no observed difference between liposomal doxorubicin, liposomal daunorubicin and paclitaxel. PMID: 25221796 [PubMed - indexed for MEDLINE] (Source: Cochrane Database of Systematic Reviews)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Depression and social support among women living with the substance abuse, violence, and hiv/aids syndemic: a qualitative exploration - Illangasekare SL, Burke JG, Chander G, Gielen AC.
BACKGROUND: Intimate partner violence (IPV), HIV/AIDS, and substance use are described as the SAVA "syndemic" among low-income urban women because of their intersecting and synergistic presence in these women's lives. Depressive symptoms are significantly ... (Source: SafetyLit: All (Unduplicated))
Trends in hospital admissions at a Department for Infectious Diseases in Italy from 1995 to 2011 and implications for health policies
Conclusions: Older age, a higher number of comorbidities, a longer hospital LOS for certain conditions, and a higher rate of HSOT characterize the patients admitted to this ID department in recent years. Despite progress in treatment and management, infectious diseases continue to be a major threat to human health. The current challenge for ID departments is the treatment of complex cases, often associated with chronic diseases in elderly patients. Continuous monitoring at a local and national level will allow early identification of changes in the epidemiological patterns of IDs and provide information for healthcare system planning. (Source: BioMed Central)
Targeting the C-type Lectins-Mediated Host-Pathogen Interactions with Dextran.
This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page. PMID: 25224349 [PubMed - in process] (Source: J Pharm Pharm Sci)
U.N. Urged to Reaffirm Reproductive Rights in Post-2015 Agenda
Millions of women in Pakistan do not have access to family planning services. Credit: Zofeen Ebrahim/IPSBy Thalif DeenUNITED NATIONS, Sep 19 2014 (IPS)The U.N.&#8217;s post-2015 development agenda has been described as the most far-reaching and comprehensive development-related endeavour ever undertaken by the world body.But where does population, family planning and sexual and reproductive health rights (SRHR) fit into the proposed 17 Sustainable Development Goals (SDGs), which are an integral part of that development agenda?"We must continue to fight until every individual, everywhere on this planet, is given the opportunity to live a healthy and sexual reproductive life." -- Purnima Mane, head of Pathfinder InternationalOf the 17, Goal 3 is aimed at &#8220;ensuring healthy lives and pro...
Namibia: Rising HIV Infections Threat to Coastal Economy
[Namibian]AT least 1 282 Namibians tested HIV-positive last year in the Erongo region alone, a figure which the Namibia Network of AIDS Service Organisations (Nanaso) says may hurt economic activities in the region. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Liberia: 'Let Us Not Forget the Silent Killer'
[NEWS]A former Managing Editor of The News Newspaper Joseph G. Bartuah has reminded Liberians and other folks on social media not to forget about the original silent killer, HIV/AIDS. (Source: AllAfrica News: HIV-Aids and STDs)
Uganda: Demand for ARVs Still Outpaces Supply
[Observer]Despite a remarkable increase in access to antiretroviral therapy (ART) between 2003 and 2009, the number of people in need of the drugs continues to outpace the response. (Source: AllAfrica News: HIV-Aids and STDs)
HIV Provider-Patient Communication Regarding CVD RiskHIV Provider-Patient Communication Regarding CVD Risk
Are HIV clinicians sufficiently addressing CVD risk factors with their patients? Journal of the International Association of Providers of AIDS Care (Source: Medscape Today Headlines)
Uganda: Let's Fight Stigma Against Youths With HIV
[Observer]Uganda is acclaimed as a champion against HIV/Aids for decades, having made tremendous strides in containing the pandemic and reversing its spread. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: NGO Empowers 22 HIV Positive Persons in Jigawa
[Leadership]A Jigawa-based NGO, Society for Community Awareness and Mobilisation (SOCHAM), on Thursday distributed working equipment to 22 persons living with HIV and AIDS in Hadejia town. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Nigeria: U.S. Fund Ends for 13,000 Orphans
[Daily Trust]A five-year project funded by the US government has closed after enrolling some 13,000 children orphaned and left vulnerable on account of HIV/AIDS in Bauchi, Kaduna and Katsina. (Source: AllAfrica News: HIV-Aids and STDs)
Hearing aids: How to choose the right one
(Source: MayoClinic.com Full Feed)
The influence of depressive symptoms and substance use on adherence to antiretroviral therapy. A cross-sectional prevalence study.
CONCLUSION: ART interruption may reflect recall errors and changes to the Brazilian demographic characteristics of HIV infection. The missed doses may reflect lifestyle characteristics of younger individuals. Attendance for HIV-positive individuals, particularly younger patients, should involve interventions and counseling in relation to the presence of depressive symptoms. PMID: 25250800 [PubMed - as supplied by publisher] (Source: Sao Paulo Medical Journal)
Temporal trends in critical events complicating HIV infection: 1999?2010 multicentre cohort study in France
Conclusions Progressive ageing, increasing prevalence of comorbidities (mainly malignancies), a steady decline in AIDS-related illnesses and improved benefits from life-sustaining therapies were the main temporal trends in HIV-infected patients requiring ICU admission. (Source: Intensive Care Medicine)
Granulomatous Amoebic Encephalitis: Ghost Response of an Immunocompromised Host?
Authors: Baig AM Abstract Naegleria fowleri, Acanthamoeba and Balamuthia mandrillaris spp. are known to cause fatal amebic encephalitis. Here we attempt to draw the attention of these cases being reported as "Granulomatous Amebic Encephalitis" (GAE), and of its occurrences in immunocompromised individuals and patients with AIDS. GAE, like any other granulomatous inflammations can occur only in the presence of ample numbers of CD4+ve T-lymphocytes. We therefore recommend the use of this terminology with obligation and only when the diagnostic criteria's have been met. Through extensive reviews of manuscripts published over a period of 5 decades on the relevant topic and cytokine studies and/or morphological evidences provided in published manuscripts were analyzed in detail by indep...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Multimodality vaccination against clade C SHIV: Partial protection against mucosal challenges with a heterologous tier 2 virus.
Authors: Lakhashe SK, Byrareddy SN, Zhou M, Bachler BC, Hu SL, Villinger F, Stock S, Vargas-Inchaustegui DA, Robert-Guroff M, Johnson WE, Polonis VR, Forthal DN, Loret EP, Rasmussen RA, Ruprecht RM, Clade C Program Project Group, Clade C Program Project Group Abstract We sought to test whether vaccine-induced immune responses could protect rhesus macaques (RMs) against upfront heterologous challenges with an R5 simian-human immunodeficiency virus, SHIV-2873Nip. This SHIV strain exhibits many properties of transmitted HIV-1, such as tier 2 phenotype (relatively difficult to neutralize), exclusive CCR5 tropism, and gradual disease progression in infected RMs. Since no human AIDS vaccine recipient is likely to encounter an HIV-1 strain that exactly matches the immunogens, we immunized...
San Francisco Politician: 'I Take a Pill Called Truvada'San Francisco Politician: 'I Take a Pill Called Truvada'
Truvada is a FDA-approved drug that dramatically reduces the risk of HIV infection. Kaiser Health News (Source: Medscape Medical News Headlines)
Kenya: Aidspan Conducts Survey of East African Sub - and Sub-Sub Recipients of Global Fund Grants
[GFO]Aidspan has released a brief analysis of a survey conducted of sub- and sub-sub recipients of Global Fund grants in four East Africa countries: Kenya, Rwanda, Tanzania and Uganda. All four countries are classified by the Grants Management unit as High Impact Africa 1 countries. (Source: AllAfrica News: HIV-Aids and STDs)
Liberia: On the Border Between Côte d'Ivoire and Liberia, a Challenge in Supporting HIV-Positive Women
[GFO]Ten years of armed conflict and perpetual insecurity have driven HIV prevalence in Côte d'Ivoire to heretofore unseen levels -- especially among women in the western zone on the Liberian border. Many of these women were infected as a result of sexual violence perpetuated by one or another of the marauding armed groups that terrorized the region for over a decade; others were infected after turning to prostitution to escape extreme poverty. (Source: AllAfrica News: HIV-Aids and STDs)
Cameroon: CIRCB, African Synergy - Italian Ambassador Pays Courtesy Visit
[Cameroon Tribune]Mrs Samuela Isopa on September 17, 2014 expressed satisfaction with the fruitful cooperation between her country and Cameroon. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Zambia: Curb High Teen Pregnancies
[Times of Zambia]Statistics for 2013 showing that 12,500 pregnancies were recorded at primary school level while another 2,428 in secondary schools, as announced by the Ministry of Education, are not only shocking but a choking problem on efforts to educate the girl-child. (Source: AllAfrica News: HIV-Aids and STDs)
Liberia: 'Ebola Is Not the Only Deadly Virus' - HIV Carriers
[Analyst]People infected with the deadly HIV, the virus that causes the AIDS disease in Liberia have complained that they are being ignored at the advent of the out outbreak of the Ebola virus in the country. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: 'Youth Reproductive, Sexual Health Education Key to Development'
[Guardian]NEARLY one third of Nigeria'stotal population of 160 million is between the ages of 10 and 24. Nigerian adolescents' sizeable share of the population makes them integral to the country's social, political and economic development. Nigeria's development is compromised by the sexual and reproductive health issues afflicting its youth. Lack of sexual health information and services make young people vulnerable to sexually transmitted infections (STIs) and unintended pregnancy. (Source: AllAfrica News: HIV-Aids and STDs)
Improving Health Infrastructure Across Nations Key to Maintaining Successful Programs
Without attention to the management, financing, and infrastructure that support health services in low- and middle-income countries, it will not be possible to maintain the progress of global health programs, such as the U.S. President's Emergency Plan for AIDS Relief (PEPFAR) and response efforts to widespread pandemics, says a new report from the Institute of Medicine. For example, malaria eradication efforts may have failed because case surveillance was not integrated into primary care. The report says an aid strategy that emphasizes research and training, global public goods, efficient management, and rigorous program evaluation would go far to improving the health infrastructure in these countries and to making good use of the proportionately decreasing prominence of U.S. assistance i...
South Africa: HIV, Aids Communications Strategy for Youth On the Cards
[SAnews.gov.za]Deputy President Cyril Ramaphosa says there is a plan to develop a comprehensive communications strategy to address the prevalence HIV and Aids among young men and women. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Nigeria: Reproductive Health Tops Hurdles to Youth Development in Nigeria
[Daily Independent]Poor access to Reproductive Health has emerged as a major reason youths in Nigeria are unable to develop intellectually. (Source: AllAfrica News: HIV-Aids and STDs)
Implementing strategies in consumer and community engagement in health care: results of a large-scale, scoping meta-review
Conclusions: The diversity of the field indicates the need to measure each component of CCE. This meta-review provides the basis for development of a new eight stage model of consumer and community engagement. This model emphasises the importance of clarity and focus, as well as an extensive evaluation of contextual factors within specific settings, before the implementation of CCE strategies, enabling those involved in CCE to determine potential facilitators and barriers to the process. (Source: BMC Health Services Research)
Interventions to enhance informed choices among invitees of screening programmes--a systematic review
Conclusion: The empirical evidence regarding interventions to improve informed decision making in screening is limited. It is unknown which strategies to enhance informed decision making are most effective, although DAs are promising. Systematic development of interventions to enhance informed choices in screening deserves priority, especially in disadvantaged groups. (Source: The European Journal of Public Health)
Electronic nicotine delivery systems for smoking cessation: where are we?
Abstract Electronic cigarettes (e-cigarettes) have surged in popularity since their introduction in 2007. Sales of e-cigarettes and related products in the US were expected to exceed $1B in 2013. With the popularity of the electronic cigarette on the rise, physicians are sure to get questions from patients about the safety of e-cigarettes and their effectiveness as tools for smoking cessation or reduction. Most users of the electronic cigarette are so-called dual users?current cigarette smokers who also use e-cigarettes. The appeal of these devices is largely based on a perception that they are not as harmful as traditional cigarettes. Other factors that contribute to the popularity of e-cigarettes are that they have the look and feel of a traditional cigarette, that they can be...
Type 1 Diabetes Education Aids Transition to Adult CareType 1 Diabetes Education Aids Transition to Adult Care
Providing structured education to young adults with type 1 diabetes soon after their transition from pediatric to adult care shows benefits in terms of glycemic control. Medscape Medical News (Source: Medscape Diabetes Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Certain gut bacteria may induce metabolic changes following exposure to artificial sweeteners
Artificial sweeteners have long been promoted as diet and health aids. But breaking research shows that these products may be leading to the very diseases they were said to help prevent: scientists have discovered that, after exposure to artificial sweeteners, our gut bacteria may be triggering harmful metabolic changes. (Source: ScienceDaily Headlines)
Malawi: Cultural and Religious Perception Dwindling Female Condom Uptake
[Malawi News Agency]Blantyre -Malawi is said to be one of the countries with low female condom consumption due to cultural and religious believes which perceive condom use as sinful, dirty and immoral. (Source: AllAfrica News: HIV-Aids and STDs)
'Smart material' chin strap harvests energy from chewing
A chin strap that can harvest energy from jaw movements has been created by a group of researchers in Canada. It is hoped that the device can generate electricity from eating, chewing and talking, and power a number of small-scale implantable or wearable electronic devices, such as hearing aids, cochlear implants, electronic hearing protectors and communication devices. (Source: ScienceDaily Headlines)
Nigeria: Katsina HIV/Aids Prevalence Rate Drops
[Daily Trust]Katsina -The Executive Director, Katsina State Agency for the Control of HIV/AIDS, Dr Muntari Hassan, said prevalence rate of the disease in the state has dropped. (Source: AllAfrica News: HIV-Aids and STDs)
Zimbabwe: Govt Fills MSF Funding Vacuum
[The Herald]Government has taken over the funding of HIV and Aids programmes in Beitbridge District after Medecins Sans Frontieres (MSF), a local non-governmental organisation, was chased away for allegedly meddling in local politics. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Zimbabwe: HIV+ Woman Jailed 20 Years for Rape
[The Herald]A 38-year-old HIV-positive Harare woman, who sexually abused two teenage boys aged 14 and 15, will spend the next 20 years in jail. (Source: AllAfrica News: HIV-Aids and STDs)
Class II Special Controls Guideline: Tryptase Test System as an Aid in the Diagnosis of Systemic Mastocytosis - Guideline for Industry and Food and Drug Administration Staff (PDF - 142KB)
A tryptase test system is a device that aids in the diagnosis of systemic mastocytosis. It is intended for in vitro diagnostic use as an aid in the clinical diagnosis of patients with a suspicion of systemic mastocytosis in conjunction with other... (Source: Food and Drug Adminstration (FDA): CDRHNew)
A qualitative insight of HIV/AIDS patients' perspective on disease and disclosure
ConclusionsThe outcomes provided basic information about patients' perceptions towards disease and status disclosure among HIV/AIDS patients which can help in the designing and improvising existing strategies to enhance disease awareness and acceptance and will also serve as baseline data for future research further focusing on this subject. (Source: Health Expectations)
JIAPAC Mourns the Loss of Joep M. A. Lange, MD, PHD
(Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
Welfare Homes for Patients Living with HIV/AIDS in Andalusia
Conclusion: The AWHs perform an important role in the care of certain types of patients with HIV infection. They require human and material resources to be able to tackle the immense difficulties associated with this group of patients. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Global Policy Review of Recommendations on Cotrimoxazole Prophylaxis among People Living with HIV
The Joint United Nations Programme on HIV/AIDS (UNAIDS) Treatment 2015 calls for expanded access to HIV care and treatment, including cotrimoxazole preventive therapy (CPT), for prevention of HIV-related morbidity and mortality. We review 115 national guidelines from 92 countries for recommendations on CPT for adults and adolescents and determine the level of consistency with the World Health Organization (WHO) guidelines. Of the 66 countries with recommendations, 5 (8%) countries recommend lifelong CPT for people living with HIV; 19 (29%) countries recommend a CD4 count threshold of &le;350 cells/mm3 or WHO clinical stages III and IV or II, III, and IV; and 19 (29%) countries recommend a CD4 count threshold of &le;200 cells/mm3. Of the 48 countries with recommendations on discontinuing CP...
Role of Education in HIV Clinical Outcomes in a Tuberculosis Endemic Setting
This study evaluated how educational attainment impacts clinical outcomes of HIV-positive patients in Durban, South Africa. The authors conducted a prospective study of 466 adult HIV-positive patients initiating antiretroviral therapy (ART) at an urban TB-HIV clinic from October 2004 to June 2007. The level of educational attainment (highest grade completed) was assessed at ART initiation. The authors measured tuberculosis treatment outcomes as well as death, lost to follow-up, viral suppression (HIV RNA &lt;400 copies/mL), and immunologic response (CD4 &ge;200 cells/mm3) at 6, 12, and 24 months after ART initiation. After 24 months of ART initiation, there were 43 deaths; viral suppression and immunologic response were observed in 88% and 83% of the remaining patients, respectively. The a...
A Case of Cerebellar Ataxia Associated with HIV Infection
Cerebellar complications of HIV infection primarily manifested in ataxia, usually arise as the result of cerebellar lesions due to opportunistic infections, vasculitis or neoplastic processes. A 28 year old female known to have HIV infection for last four years, presented to our hospital with progressive unsteadiness in walking, slurring of speech and intention tremors for the last two months. There was no family history of similar complaints, and she was on Anti retroviral treatment for last one and a half years. The results of examination were notable for severe dysarthria, slow saccades, a conspicuous dysmetria and dysdiadokokinesia. She had no cognitive, sensory or motor deficits. MRI revealed diffuse cerebellar atrophy. Extensive laboratory work up failed to disclose a cause for subac...
Glioblastoma Multiforme in an HIV-Infected Patient: An Unexpected Diagnosis
We reported a case of glioblastoma multiforme in a 42-year-old female patient with HIV infection, who had a rapid progression to AIDS. She was diagnosed with an intracerebral mass and treated as neurotoxoplasmosis with improvement in the first week of therapy. On the fourth week she had a clinical worsening evolving to death, receiving the diagnosis at necropsy. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
Elements of Condom-Use Decision Making among South African Men Who Have Sex with Men
South African men who have sex with men (MSM) are at increased risk for HIV infection, and male condoms are fundamental to HIV prevention programs. We explored condom use experiences through in-depth interviews with 34 South African MSM from Cape Town and Port Elizabeth. For data analysis, we generated a codebook and used the constant comparison method. Condom use reinforcing elements included use of alternative sexual strategies, having a high level of self-worth that was linked to protective behaviors, and use of ready-made condom negotiation scripts. Elements inhibiting condom use included perceiving substantial declines in sexual pleasure/performance, experiences of condom failure (possibly related to petroleum-based lubricant), and being in trusted relationships. Our findings suggest ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Self-Reported Preconception Care of HIV-Positive Women of Reproductive Potential: A Retrospective Study
Conclusions: Preconception care in our cohort was suboptimal. We recommend that counseling on healthy preconception should be part of routine HIV care. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
Utility of Cryptococcal Antigen Screening and Evolution of Asymptomatic Cryptococcal Antigenemia among HIV-Infected Women Starting Antiretroviral Therapy in Thailand
Cryptococcal meningitis (CM) remains a significant HIV-associated opportunistic infection in Southeast Asia and Africa, with a high burden of disease and a high mortality rate despite the availability of antiretroviral therapy (ART). We retrospectively examined the utility of cryptococcal antigen screening to identify risk for CM among 211 Thai women initiating ART. Antigenemia prevalence was 11% (n = 9) among 84 women with a CD4 count &lt;100 cells/mm3. Screening identified all women who later developed CM. Cryptococcal antigen titers decreased over time with ART. Our study confirmed findings from previous studies in Thailand and South Africa and provided novel observational data regarding the course of cryptococcal antigenemia in patients initiating ART and the poor efficacy of low-dose ...
Vitamin D Insufficiency/Deficiency in HIV-Infected Inner City Youth
Conclusions: A higher prevalence of vitamin D insufficiency/deficiency was found in our study compared to the previous large cohorts. However, patients who were prescribed TDF/EFV did not have lower vitamin D levels. Inadequate sunlight exposure in temperate latitudes and the cloud effect of the Great Lakes as well as large number of African American participants who live in the inner city area with poverty and poor diet may combine to explain these results. The effect of ARV medications on vitamin D may be washed out by the numerous other factors affecting vitamin D in our patients. Severe vitamin D deficiency seemed to be related to lower CD4 counts and CD4% but not related to HIV plasma RNA. Vitamin D supplementation did not increase CD4 counts/CD4% in our study. (Source: Journal of the...
Perceptions of Male Circumcision among Married Couples in Rural Malawi
Voluntary medical male circumcision (VMMC) is being suggested as an essential HIV prevention strategy in high-prevalence areas. These analyses reflect data collected from 360 married couples, 50% of which included a circumcised husband and the other 50% uncircumcised, in rural Malawi. Regardless of their circumcision status, men were more likely to perceive that being circumcised was less painful than having a tooth pulled, giving birth, and having malaria. Men reported having the same sexual pleasure regardless of the circumcision status, while women were 2.0 times more likely to report greater sexual pleasure with a circumcised partner. Participants identified the medical benefits of VMMC and highlighted the potential personal benefits of VMMC. As VMMC has become a promising method of HI...
Effects of Lifetime History of Use of Problematic Alcohol on HIV Medication Adherence
Conclusion: Results suggest that a history of problematic alcohol use may not impact ART adherence. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Beyond the Brain: The Role of Brain-Derived Neurotrophic Factor in Viroimmune Responses to Antiretroviral Therapy among People Living with HIV with and without Alcohol Use
Conclusion: Hazardous alcohol use was associated with BDNF alterations, which in turn were linked to a limited response to ART in terms of viral suppression and CD4 count improvements. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
Treatment Response in Association with Adherence Patterns to Highly Active Antiretroviral Therapy in Pediatric Patients with Perinatally Acquired HIV Infection
Conclusion: Alteration of adherence to HAART is a significant predictor of persistent virologic failure and high viremia in perinatally infected HIV patients. Implementation of longitudinal adherence assessments may target patients with nonsustained adherence patterns and help decrease the risk for virologic failure and disease progression. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
Adverse Drug Reactions to Antiretroviral Therapy in HIV-Infected Patients at the Largest Public Hospital in Nicaragua
Conclusion: Adverse drug reactions most frequently affected the central nervous system. No ADR was life threatening. The frequency of ADRs in this Nicaraguan patient population was less than that reported from other studies in resource-limited settings. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
Effect of Lipodystrophy on the Quality of Life among People Living with HIV (PLHIV) on Highly Active Antiretroviral Therapy
Conclusions: Lipodystrophy adversely affects QoL among PLHIV. There is a need for studies analyzing factors that can potentially improve the QoL in such individuals. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
Baseline Renal Function among Antiretroviral Therapy-Naive, HIV-Infected Patients in Southeast Nigeria
Conclusion: The authors observed a high prevalence of significant renal impairment among HIV-infected patients at the time of ART initiation. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Body mass index and the risk of incident noncommunicable diseases after starting antiretroviral therapy
ConclusionsOverweight individuals starting ART have a lower risk of developing NCDs compared with normal BMI individuals, which may reflect a biological effect of adipose tissue or differences in patient or provider behaviours. (Source: HIV Medicine)
Sex-specific disease outcomes of HIV-positive and HIV-negative drug users admitted to an opioid substitution therapy program in Spain: a cohort study
Conclusions: Significant reductions in mortality of patients in MTP are observed after nineteen years of observation. However, HIV infection shows a great impact on survival, particularly among HIV-infected women. (Source: BMC Infectious Diseases)
Development of a technical assistance framework for building organizational capacity of health programs in resource-limited settings
Conclusions: A systematic adaptation process has produced a qualitative framework that can inform implementation strategies in support of country led HIV care and treatment programs. The framework, as a well-received iterative process focused on technical assistance, may have broader utility in other global programs. (Source: BMC Health Services Research)
A Metasynthesis of Patient-Provider Communication in Hospital for Patients with Severe Communication Disabilities: Informing New Translational Research.
Authors: Hemsley B, Balandin S Abstract Poor patient-provider communication in hospital continues to be cited as a possible causal factor in preventable adverse events for patients with severe communication disabilities. Yet to date there are no reports of empirical interventions that investigate or demonstrate an improvement in communication in hospital for these patients. The aim of this review was to synthesize the findings of research into communication in hospital for people with severe communication disabilities arising from lifelong and acquired stable conditions including cerebral palsy, autism, intellectual disability, aphasia following stroke, but excluding progressive conditions and those solely related to sensory impairments of hearing or vision. Results revealed six co...
Characterization of T-cell responses to conserved regions of the HIV-1 proteome in the BALB/c mice.
Authors: Ondondo B, Abdul-Jawad S, Bridgeman A, Hanke T Abstract A likely requirement for a protective vaccine against human immunodeficiency virus type 1 (HIV-1)/AIDS is, in addition to eliciting antibody responses, induction of effective T cells. To tackle HIV-1 diversity by T-cell vaccines, we designed an immunogen HIVconsv derived from the most functionally conserved regions of the HIV-1 proteome and demonstrated its high immunogenicity in humans and rhesus macaques when delivered by regimens combining plasmid DNA, non-replicating simian (chimpanzee) adenovirus ChAdV-63 and non-replicating modified vaccinia virus Ankara (MVA) as vectors. Here, we aimed to increase the decision power for iterative improvements of this vaccine strategy in the BALB/c mouse model. First, we found t...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Ulnar fractures with bisphosphonate therapy: a systematic review of published case reports
Conclusion Ulnar fractures in patients with bisphosphonate therapy demonstrate features similar to those described for atypical femoral fractures, suggesting that these fractures could also possibly be due to bisphosphonate use. However, the ulna appears to be able to tolerate longer periods of alendronate use prior to fracture development. The mechanism and characteristics of these fractures additionally suggest the presence of repetitive stress that accumulates over time due to suppressed bone remodelling in patients on bisphosphonates, eventually resulting in these fractures. (Source: Osteoporosis International)
South Africa: People With HIV Should Be Able to Fight for Their Country
[GroundUp]There is no reason people with HIV shouldn't be soldiers, says Tim Flack, who served in the navy and is the Western Cape representative for the South African National Defence Force Union. (Source: AllAfrica News: HIV-Aids and STDs)
Female Sex Workers and Their Gatekeepers in China: Implications for HIV/STI Prevention
Female sex workers (FSWs) play a key role in HIV/AIDS transmission and their gatekeepers play a crucial role in shaping their behaviors. Limited studies are available on the relationship between FSWs and gatekeepers. In the current study we used an ethnographic approach to examine the dynamic and multidimensional relationship of FSWs and their gatekeepers from the perspectives of both parties. We recruited 38 FSWs and 16 gatekeepers from different types of commercial sex venues in Guangxi, China, and conducted in-depth individual interviews. Our data suggest that FSWs and gatekeepers maintain an interdependent and reciprocal relationship during their business practice, but gatekeepers exert significant influence and control over FSWs. Designing culturally appropriate HIV/STI-prevention pro...
A Culture of Future Planning: Perceptions of Sexual Risk Among Educated Young Adults
In this study we examined how social processes, specifically the acquisition of postsecondary education and capital, shaped perceptions of sexual risk and impacted sexual practices and sexual health among young adults. Using qualitative research methods we collected and analyzed data among students attending a 4-year university in the northeastern region of the United States over a 1-year period. By analyzing participants&rsquo; narratives, we found that the reproduction of shared norms and values encouraged educated young adults to focus on educational and professional success, pressing many of them to be concerned about preventing pregnancy rather than preventing disease transmission, and increasing their risk for sexually transmitted infections, including HIV/AIDS. Sexual-health educato...
An exploration of decision aid effectiveness: the impact of promoting affective vs. deliberative processing on a health?related decision
ConclusionsThis investigation of the effect of affective and deliberative processes in DA?supported decision making has implications for the design and use of DAs. DA effectiveness may be enhanced by incorporating a simple instruction to focus on the details of the information. (Source: Health Expectations)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Economic impact of HIV/AIDS: a systematic review in five European countries
This study also shows that there are relatively few studies of HIV costs in European countries compared to other diseases. Finally, we conclude that the methodology used in many of the studies carried out leaves ample room for improvement and that there is a need for these studies to reflect the economic impact of HIV/AIDS beyond health care including other components of social burden. (Source: Health Economics Review)
Study Dampens HOPE of HIV Organ DonationsStudy Dampens HOPE of HIV Organ Donations
The HIV Organ Policy Equity (HOPE) Act, which legalizes research into transplants from HIV-positive donors to HIV-positive recipients, is less than a year old, but already new data question its usefulness. Medscape Medical News (Source: Medscape Medical News Headlines)
Nigeria: 'New HIV Cases Discovered in Married Couples'
[Daily Trust]Kaduna -New cases of Human Immuno-deficiency Virus (HIV) in Kaduna State are mostly discovered among married people than singles, Assistant coordinator and representative of the Kaduna State Health Control Agency, Mrs. Catherin A. Yakubu, has said. (Source: AllAfrica News: HIV-Aids and STDs)
Liberia: Ebola Stalls HIV Drugs Importation - LIPNEP Alarms
[New Dawn]The Liberia Network of People Living with HIV or LIBNEP+, representing People living with HIV peer support groups and associations across Liberia, says it is deeply troubled by the current outbreak of the Ebola disease in the County. (Source: AllAfrica News: HIV-Aids and STDs)
HIV Infection and Incidence of Ischemic StrokeHIV Infection and Incidence of Ischemic Stroke
Do HIV-infected individuals have a higher risk of ischemic stroke? AIDS (Source: Medscape Today Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Effectiveness of Once-Daily ART vs a Triple-Tablet RegimenEffectiveness of Once-Daily ART vs a Triple-Tablet Regimen
Switching from a once-daily, single tablet ART regimen to a triple-tablet regimen may result in drug cost savings, but are there other risks involved? JAIDS: Journal of Acquired Immune Deficiency Syndromes (Source: Medscape Today Headlines)
Nigeria: 'HIV/Aids On the Decline in Zamfara'
[Leadership]HIV/AIDS is "now fast on the decline in Zamfara state", the Commissioner of Information, Alhaji Ibrahim Birnin-Magaji has disclosed. (Source: AllAfrica News: HIV-Aids and STDs)
Tanzania: Knowledge Crucial in Preventing Mother-to-Child HIV/Aids Transmission
[Daily News]LACK of access to knowledge among mothers in the country is one among the main setbacks in preventing motherto- child transmission of HIV/ AIDS, the Country Director of Elizabeth Glaser Pediatric AIDS Foundation (EGPAF) Dr Joroen Bosch says. (Source: AllAfrica News: HIV-Aids and STDs)
Zimbabwe: Male Circumcision Up in Midlands
[New Zimbabwe]THE National Aids Council (NAC) has said more men are undergoing voluntary male circumcision in the Midlands province as the group steps up its fight against HIV and Aids. (Source: AllAfrica News: HIV-Aids and STDs)
Zimbabwe: Live-in Girlfriend Conceals HIV Status
[The Herald]A Chitungwiza woman allegedly lived with her boyfriend for 13 years without revealing to him that she was on anti-retroviral therapy as she is HIV positive.This emerged at the Chitungwiza Magistrates' Court on Thursday when the 46-year-old man appeared before Mr Musaiona Shortgame charged with threats to murder and malicious damage to property. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Nigeria: Celebrating the Triumph of Intellectual Prowess Over Vision Challenge
[Daily Independent]It is certainly sure that most of those who have been reading my column for many years now don't have the slightest idea that this columnist is one without any vision. That is to say, he is vision challenged. To many, it will be an astonishing thing to hear because letting the cat of the cage throw open several questions. How does he write: how does he read to write: and of course so many questions and why the story now? (Source: AllAfrica News: HIV-Aids and STDs)
Impact of Clinical and Therapeutic Factors on Incident Cardiovascular and Cerebrovascular Events in a Population?Based Cohort of HIV?Infected and Non?HIV?Infected Adults
ConclusionsAfter adjusting for traditional risk factors and sociodemographic differences, there is higher risk of incident cardiovascular events among HIV?infected individuals exposed to combined antiretroviral medications compared to the general population. (Source: Clinical Cardiology)
High prevalence and incidence of sexually transmitted infections among women living in Kwazulu- Natal, South Africa
Background and objectives: Sexually transmitted infections (STIs) contribute largely to the burden of health in South Africa and are recognized as major contributors to the human immunodeficiency virus (HIV) epidemic. Young women are particularly vulnerable to STIs. The purpose of this secondary analysis was to examine the risk factors associated with prevalent and incident STIs among women who had participated in three clinical trials. Methods: A total of 5,748 women were screened and 2293 sexually active, HIV negative, non-pregnant women were enrolled in three clinical trials in Kwazulu-Natal, South Africa. The prevalence of individual STIs Chlamydia trachomatis (CT), Neisseria gonorrhea (NG), syphilis, and Trichomonas vaginalis (TV) was assessed at screening; and incident infections wer...
Greater frequency of CD5-negative CD8+ T cells against human immunodeficiency virus type 1 than other viruses is consistent with adaptation to antigenic variation
Conclusions: This deficit in CD5 expression selective for HIV-specific CD8+ T cells is consistent with in vivo adaptation to low avidity HIV peptide variants and has potential consequences for CD8+ T cell expansion, cross-reactivity and autoreactivity. (Source: AIDS Research and Therapy)
Facial analysis technology aids diagnoses of genetic disorders
(Source: American Journal of Medical Genetics Part A)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Abasic phosphorothioate oligomers inhibit HIV-1 reverse transcription and block virus transmission across polarized ectocervical organ cultures.
Authors: Fraietta JA, Mueller YM, Lozenski KL, Ratner D, Boesteanu AC, Hancock AS, Lackman-Smith C, Zentner IJ, Chaiken IM, Chung S, LeGrice SF, Snyder BA, Mankowski MK, Jones NM, Hope JL, Gupta P, Anderson SH, Wigdahl B, Katsikis PD Abstract In the absence of universally available anti-retroviral (ARV) drugs or a vaccine against HIV-1, microbicides may offer the most immediate hope for controlling the AIDS pandemic. The most advanced and clinically effective microbicides are based on ARV agents that interfere with the earliest stages of HIV-1 replication. Our objective was to identify and characterize novel ARV-like inhibitors, as well as demonstrate their efficacy at blocking HIV-1 transmission. Abasic phosphorothioate 2' deoxyribose backbone (PDB) oligomers were evaluated in a v...
High prevalence and incidence of sexually transmitted infections among women living in Kwazulu-Natal, South Africa
Background and objectives: Sexually transmitted infections (STIs) contribute largely to the burden of health in South Africa and are recognized as major contributors to the human immunodeficiency virus (HIV) epidemic. Young women are particularly vulnerable to STIs. The purpose of this secondary analysis was to examine the risk factors associated with prevalent and incident STIs among women who had participated in three clinical trials. Methods: A total of 5,748 women were screened and 2293 sexually active, HIV negative, non-pregnant women were enrolled in three clinical trials in Kwazulu-Natal, South Africa. The prevalence of individual STIs Chlamydia trachomatis (CT), Neisseria gonorrhea (NG), syphilis, and Trichomonas vaginalis (TV) was assessed at screening; and incident infections wer...
Effectiveness of first-line antiretroviral therapy in the IPEC cohort, Rio de Janeiro, Brazil.
CONCLUSIONS: Our results show that in Brazil, a middle-income country with free access to treatment, over three-quarters of patients receiving routine care reached virologic suppression on first-line ART by the end of the first year. Higher education, more recent ART initiation and clinical trial participation were associated with improved outcomes both for the 12-month and the 24-month endpoints, suggesting that further studies are needed to understand what aspects relating to these factors lead to higher virologic suppression. PMID: 25206924 [PubMed] (Source: AIDS Research and Therapy)
Risk of cervical cancer in women with autoimmune diseases, in relation with their use of immunosuppressants and screening: Population?based cohort study
Abstract Severely immunosuppressed individuals have a strongly increased risk of cervical cancer. In patients with autoimmune diseases (AID), who have defects in their immune system and receive immunosuppressants, the risk of cervical cancer is less clear. We conducted a cohort study, using Danish nationwide population?based registers including information on AID diagnoses, immunosuppressant intake, cervical screening participation, and cervical cancer incidence. Standardized incidence ratios (SIR) were computed to compare the risk of cervical cancer in AID patients to that of the general population. Hazard ratios (HR) from time?dependent Cox models stratified by AID were used to explore the effect of the most frequently used immunosuppressants, taking into account potential dose?res...
Sodium nitroprusside, a nitric oxide donor for novel treatment of schizophrenia, may also modulate dopaminergic systems
?Schizophrenia is arguably the worst disease affecting mankind, even AIDS not excepted?. Since this statement in 1988 (Editors, 1988), schizophrenia still remains a major challenge to medicine, with up to 60% of patients not responding adequately to treatment despite the relatively large arsenal of antipsychotics currently available. By modulating the nitric oxide (NO) pathway, a new paradigm for schizophrenia treatment apparently involving modulation of nitric oxide (NO) has been proposed (Oliveira et al., 2011). (Source: Schizophrenia Research)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Maternal mortality at muhimbili national hospital in Dar-es-Salaam, Tanzania in the year 2011
Conclusion: There is a high maternal mortality ratio at MNH. Hypertensive disorders of pregnancy, post partum haemorrhage and anaemia are the leading causes of maternal deaths in this institution. Multiple substandard care factors identified both at individual and health care service levels that contributed to maternal deaths. There is a need for increasing efforts in the fight to reduce maternal deaths at the institution. A more pro-active role from the referring facilities in the region is needed. (Source: BMC Pregnancy and Childbirth - Latest articles)
Combination HIV Prevention Interventions: The Potential of Integrated Behavioral and Biomedical Approaches
Abstract Combination HIV prevention interventions that integrate efficacious behavioral and biomedical strategies offer the potential to reduce new HIV infections. We overview the efficacy data for three biomedical HIV prevention approaches, namely microbicides, pre-exposure prophylaxis (PrEP), and HIV vaccination; review factors associated with differential acceptability and uptake of these methods; and suggest strategies to optimize the effectiveness and dissemination of combination HIV prevention approaches. A narrative review was conducted highlighting key efficacy data for microbicides, PrEP, and an HIV vaccination and summarizing acceptability data for each of the three biomedical HIV prevention approaches. Recommendations for the integration and dissemination of combined be...
All-Cause and Cause-Specific Mortality Among Us Youth: Socioeconomic and Rural-Urban Disparities and International Patterns
Analyzed the socioeconomic and ruralurban disparities in all-cause mortality and mortality from leading causes of death, including homicide, suicide, unintentional injuries, and HIV/AIDS, among U.S. youth aged 1524. -- (Source: Rural publications via the Rural Assistance Center)
Cameroon: Aids-Free Holidays - Peer Educators Hailed for Successful Campaign
[Cameroon Tribune]The commitment of the First Lady, Founding President of African Synergy Against AIDS and Suffering, Madam Chantal Biya in raising collective awareness with regard to the socio-economic consequences of the HIV/AIDS pandemic, again took centre stage in Buea yesterday, 10th September 2014. (Source: AllAfrica News: Health and Medicine)
[Comment] MDG 6 and beyond: from halting and reversing AIDS to ending the epidemic
The global community strongly agrees on the need for coordinated action in the response to AIDS and on the opportunity to increase results by focusing on populations at increased risk of HIV. When the UN member states adopted the Millennium Development Goals (MDGs) in 2000, they identified in MDG 6 one of the goals to be a reversal in the spread of HIV: ?Combat HIV, tuberculosis and malaria?. Partners in global health have worked hard to make that goal a reality and have achieved tremendous progress. (Source: LANCET)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
[Comment] Time for a revolution in reporting of global health data
The United Nations Millennium Declaration in 2000, when the world agreed to the Millennium Development Goals (MDGs), set in motion undoubtedly the most concerted effort for poverty alleviation and improvement in global health. The declaration prompted substantial increases in financing for global health, both from traditional donors and innovative financing sources, scaling up preventive and life-saving interventions. For the health MDGs (MDG 4, to reduce child mortality; MDG 5, to improve maternal health; and MDG 6, to combat HIV/AIDS, malaria, and other diseases), the reported figures show impressive achievements overall?yet these achievements remain elusive for the poorest and most needy countries. (Source: LANCET)
Zambia: Chikanta Chiefdom Fights HIV/Aids
[Times of Zambia]WITH the cure for HIV/AIDS still elusive, it is clear that the fight against the pandemic cannot be restricted to one group but all people have a role to play in stopping it. (Source: AllAfrica News: HIV-Aids and STDs)
Uganda: Health Workers Held Over Fake HIV Results
[Observer]Police in Luweero recently arrested two laboratory attendants on suspicion of issuing fake 'HIV-negative' test results to a client. (Source: AllAfrica News: HIV-Aids and STDs)
Zimbabwe: Woman Acquitted of Wilfully Transmitting HIV
[The Herald]A Chitungwiza woman who was arraigned before the courts by her ex-husband over allegations that she deliberately infected him with HIV was on Monday acquitted of the charges. (Source: AllAfrica News: HIV-Aids and STDs)
Knowledge of HIV/AIDS and predictors of uptake of HIV counseling and testing among undergraduate students of a privately owned university in Nigeria
Conclusion: The participants' knowledge about HIV /AIDS was quite good, the willingness to have HIV test done was high and the knowledge of a place where test can be done was nearly universal yet HIV testing was low. Innovative school based programs should be put in place to leverage on the willingness to test and translate it to periodic HIV testing. (Source: BMC Research Notes)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
The leak and endobronchial peek
A 42-year-old man from Afghanistan was referred to hospital as a case of non-resolving pneumonia. He had fever and productive cough of thick white sputum for 4&nbsp;months without response to antibiotics. There was no history of haemoptysis, sick contacts, recent travel, weight loss, substance abuse or HIV risk factors. He was a non-smoker with unremarkable family and environmental history. On examination, he was febrile (temp=39.1&deg;C) with stable haemodynamics. Oxygen saturation was 96% while breathing room air at rest and finger nail clubbing was absent. Chest auscultation revealed bronchial breathing on the left upper lung zone. The rest of his examination was unremarkable. Except for mild neutrophilic leukocytosis, complete blood count (CBC) was unremarkable. Moderate elevation of e...
FDA Updates Stribild Labeling
On August 28, 2014, FDA approved updates to the label for Stribild (elvitegravir 150 mg/cobicistat 150 mg/emtricitabine 200 mg/tenofovir 300 mg) fixed-dose combination tablets. The label was updated with efficacy, resistance, and safety data from two clinical trials; renal information; and drug interaction information. The updated labeling for Stribild is available at the&nbsp;FDA website.&nbsp; More information is available:&nbsp; FDA:&nbsp;Press release AIDSinfo:&nbsp;Patient fact sheet on Stribild (Source: AIDSinfo At-a-Glance: Offering Information on HIV/AIDS Treatment, Prevention, and Research, A Service of the U.S. Department of Health and Human Services (DHHS))
September 18 is National HIV/AIDS and Aging Awareness Day
National HIV/AIDS and Aging Awareness Day is a day set aside each year to recognize the impact of HIV/AIDS among older adults. According to the&nbsp;Centers for Disease Control and Prevention (CDC), adults aged 55 and older accounted for 19% of the estimated 1.1 million people living with HIV infection in the United States in 2010. Older Americans are more likely than younger Americans to be diagnosed with HIV infection late in the course of their disease, which may mean a later start to treatment, possibly causing more damage to their immune system. This can lead to poorer prognoses and shorter HIV-to-AIDS intervals. Visit our&nbsp;National HIV/AIDS and Aging Awareness Day webpage&nbsp;[en espa&ntilde;ol] to learn more about this observance and to find information on HIV/AIDS and aging. ...
NIH-Led Scientists Discover HIV Antibody that Binds to Novel Target on Virus
&quot;An NIH-led team of scientists has discovered a new vulnerability in the armor of HIV that a vaccine, other preventive regimen or treatment could exploit. The site straddles two proteins, gp41 and gp120, that jut out of the virus and augments other known places where broadly neutralizing antibodies (bNAbs) bind to HIV. This newly identified site on the viral spike is where a new antibody found by the scientists in an HIV-infected person binds to the virus. Called 35O22, the antibody prevents 62 percent of known HIV strains from infecting cells in the laboratory and is extremely potent, meaning even a relatively small amount of it can neutralize the virus.&quot; More information is available: NIAID: Press release (Source: AIDSinfo At-a-Glance: Offering Information on HIV/AIDS Treat...
The importance of the abdominal X-radiograph is acute ulcerative colitis
Answers From questions on page 188 Figure&nbsp;1 shows large bowel dilatation. Figure&nbsp;2 demonstrates worsening colonic dilatation, despite aggressive medical management, consistent with toxic megacolon extending proximally to the caecum. In keeping with an acute flare of inflammatory bowel disease mucosal thickening and loss of haustral folds is also present. Toxic megacolon is a catastrophic complication of ulcerative colitis requiring surgical intervention. This patient subsequently underwent a subtotal colectomy with formation of an ileostomy. Inflammatory bowel disease has a more severe phenotype in children.1 Persistent colonic dilatation (&ge;56&nbsp;mm) strongly predicts future toxic megacolon and is associated with a higher rate of corticosteroid failure.2 3 The absence of gas...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Conference Ethics in the Age of AIDS
(Source: Bioethics)
Random survival forests for competing risks
We introduce a new approach to competing risks using random forests. Our method is fully non-parametric and can be used for selecting event-specific variables and for estimating the cumulative incidence function. We show that the method is highly effective for both prediction and variable selection in high-dimensional problems and in settings such as HIV/AIDS that involve many competing risks. (Source: Biostatistics)
Multidetector CT in Renal Tuberculosis
This article gives review of pathophysiology and computed tomography features of Renal TB. (Source: Current Radiology Reports)
Kenya: HIV Patients to Be Recorded Biometrically
[The Star]THE government will from January next year begin the biometric registration of people living with HIV-Aids in Homa Bay and Mombasa counties. (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: Irresponsible HIV Reporting in Kenya
[RNW Africa]Newspaper coverage of the latest Kenyan HIV statistics has tended to sketch a doomsday scenario - for which there is no evidence. Is this misrepresentation of the facts based on sensationalism or ignorance, wonders a sexual health expert. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Africa: Search for New Inspector General Begins
[GFO]The Global Fund board on 9 September gave formal approval for a search to find a successor to Martin O'Malley, who announced in August that he would resign his position as Inspector General. (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: Kenya drafts Civil Society Charter to Encourage Better Participation in Concept Note Development
[GFO]In drafting a 16-point charter, Kenyan civil society signals its intention to play a larger role in the allocation of Global Fund resources to the fight against the three diseases (Source: AllAfrica News: HIV-Aids and STDs)
Africa: TRP Flags Shortcomings as Concept Notes Keep Rolling in
[GFO]By mid-September, 66 concept notes worth over $6 billion will have begun the screening process (Source: AllAfrica News: HIV-Aids and STDs)
Africa: Govts Urged to Prioritise Youth to End Aids By 2030
[Key Correspondents]The goal to end AIDS by 2030 may go unaccomplished unless young people are prioritised in sexual and reproductive health policy and programmes. (Source: AllAfrica News: Health and Medicine)
The Importance of Retention in HIV CareThe Importance of Retention in HIV Care
Dr. Benjamin Young reviews 2 recently published articles that highlight the challenges and rewards of successful patient retention in HIV medical care. Medscape HIV/AIDS (Source: Medscape Pulmonary Medicine Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
[Special Issue News] After the windfall
Investments in global health began growing in the 1990s then exploded after the turn of the century. Rich countries stepped up their donations, with much of the funding channeled through new public-private partnerships like the Global Fund to Fight AIDS, Tuberculosis and Malaria. But since 2008, those countries have tightened their belts; developing countries?some of which enjoy robust economic growth?are expected to shoulder more of the cost. And, increasingly, people are asking for hard data about the return on investment. In this special news section, Science tracks the impact of the explosion in funding for global health?and what happens now that it's over. Author: Martin Enserink (Source: Science: This Week)
PTEN Hopping on the Cell Membrane Is Regulated via a Positively-Charged C2 Domain
by Masato Yasui, Satomi Matsuoka, Masahiro Ueda PTEN, a tumor suppressor that is frequently mutated in a wide spectrum of cancers, exerts PI(3,4,5)P3 phosphatase activities that are regulated by its dynamic shuttling between the membrane and cytoplasm. Direct observation of PTEN in the interfacial environment can offer quantitative information about the shuttling dynamics, but remains elusive. Here we show that positively charged residues located in the c?2 helix of the C2 domain are necessary for the membrane localization of PTEN via stable electrostatic interactions in Dictyostelium discoideum. Single-molecule imaging analyses revealed that PTEN molecules moved distances much larger than expected had they been caused by lateral diffusion, a phenomenon we call ?hopping.? Our novel s...
Optimal treatment adherence counseling outcomes for people, living with HIV and limited health literacy.
Authors: Pellowski JA, Kalichman SC, Grebler T Abstract ABSTRACT Limited health literacy has been shown to contribute to poor health, including poor adherence to antiretroviral therapy (ART) in people living with HIV/AIDS, over and above other indicators of social disadvantage and poverty. Given the mixed results of previous interventions for people with HIV and low health literacy, investigating possible targets for improved adherence is warranted. The present study aims to identify the correlates of optimal and suboptimal outcomes among participants of a recent skills-based medication adherence intervention (Kalichman et al., 2013). Participants included in this secondary analysis were 188 men and women living with HIV who had low health literacy as determined by scoring ?90% ...
Multiple loss-of-function 5-O-glucosyltransferase alleles revealed in Vitis vinifera, but not in other Vitis species.
In this study, we surveyed allelic variation of the 5-O-glucosyltransferase gene (5GT) in 70 V. vinifera ssp. vinifera cultivars, 52 V. vinifera ssp. sylvestris accessions, 23 Vitis hybrid grapes, and 22 accessions of seven other Vitis species. Eighteen 5GT alleles with apparent loss-of-function mutations, including seven premature stop codon mutations and six frameshift indel mutations, were discovered in V. vinifera, but not in the other Vitis species. A total of 36 5GT alleles without apparent loss-of-function mutations (W-type) were identified. These W-type alleles were predominantly present in wild Vitis species, although a few of them were also found in some V. vinifera accessions. We further evaluated some of these 5GT alleles in producing diglucoside anthocyanins by analyzing the...
Cocaine Potentiates Cathepsin B Secretion and Neuronal Apoptosis from HIV-Infected Macrophages
Abstract Substance abuse is a risk factor for HIV infection and progression to AIDS. Recent evidence establishes that cocaine use promotes brain perivascular macrophage infiltration and microglia activation. The lysosomal protease cathepsin B is increased in monocytes from patients with HIV dementia and its secretion induces 10?15 % of neurotoxicity. Here we asked if cocaine potentiates cathepsin B secretion from HIV-infected monocyte-derived macrophages (MDM) and its effect in neuronal apoptosis. Samples of plasma, CSF, and post-mortem brain tissue from HIV positive patients that used cocaine were tested for cathepsin B and its inhibitors to determine the in vivo relevance of these findings. MDM were inoculated with HIV-1ADA, exposed to cocaine, and the levels of secreted and ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Phill Wilson: What are you excited about in the fight against HIV/AIDS?
Where There?s A Will We are at a deciding moment in the trajectory of the AIDS epidemic in the United States.  As a result of recent scientific advances, we have something that just a few years ago, we couldn?t even imagine?the promise of an AIDS free generation.  We actually have the tools to end the AIDS epidemic, at least in the U.S.  We have better diagnostic tools, better surveillance tools, better treatment tools, and better prevention tools. But we have to be careful.  Sometimes we confuse being able to do something with actually doing it.  The question is less can we end the AIDS epidemic and more do we have the will to do it.  For example, getting an HIV test has never been easier or more important. Today, HIV tests are often free, painless and confidential?even anon...
Travis Sherer: What are you excited about in the fight against HIV/AIDS?
Founded in 1982 in direct response to the AIDS epidemic, GLMA has long been involved in issues related to HIV and AIDS.  Although progress has been challenging at times, there is a lot right now to be hopeful about. Significant advances in the treatment and prevention of HIV have led us to an exciting place where we are able to discuss the potential for an end to the epidemic. Condom use, antiretroviral therapies, microbicides, PreP (pre-exposure prophylaxis) and PEP (post-exposure prophylaxis) provide a wide range of tools available help prevent the transmission of HIV. Treatment as prevention is real and within our grasp. These advances are making a difference in the lives of the people living with and at risk of HIV I treat and care for every day. I have an increasing number of serodi...
Phill Wilson
President and CEOPrior to founding the Institute, Wilson served as the AIDS Coordinator for the City of Los Angeles from 1990 to 1993, the Director of Policy and Planning at AIDS Project Los Angeles from 1993 to 1996. He was co-chair of the Los Angeles County HIV Health Commission from 1990 to 1995, and was an appointee to the HRSA AIDS Advisory Committee from 1995 to 1998. Wilson was the coordinator of the International Community Treatment and Science Workshop at the 12th, 13th, 14th, 15th, and 16th International AIDS Conferences in Geneva, Switzerland; Durban, South Africa; Barcelona, Spain; Bangkok, Thailand; and Toronto, Canada. Wilson was the co-founder of the National Black Lesbian and Gay Leadership Forum and the National Task Force on AIDS Prevention. He has been involved...
Uganda: Another Step Back for Uganda's HIV Fight
[HRW]Back in the 1990s, Uganda was seen as a success story in the fight against the AIDS epidemic. HIV infection rates were falling. The country had developed strong, community based programs that provided support to those who became ill. They fought stigma and emphasized pragmatic - not ideological - approaches to preventing HIV infection. (Source: AllAfrica News: Health and Medicine)
Kenya: Homa Bay Appoints Ex-NACC Boss to Fight Aids
[The Star]HOMA Bay Governor Cyprian Awiti has appointed former National Aids Control Council director Alloys Orago as his strategic adviser on HIV. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
South Africa: Study Hails Aids Treatment Success Rates
[VOA]Johannesburg -A new medical study out of South Africa has found heartening news in the nation with the world's highest burden of HIV, the virus that causes AIDS. Their findings reveal that South Africans with HIV can live as long as HIV patients in the United States - provided they begin anti-retroviral therapy early enough. (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: Group Works to Stem Child Prostitution in Nairobi Slums
[VOA]In the Nairobi slum of Korogocho, underage girls as young as 15 are turning to prostitution to eke out a living. But an organization that rescues child prostitutes says it is achieving positive results. (Source: AllAfrica News: HIV-Aids and STDs)
Uganda: Aids Patients Reject Bitter ARVs
[Observer]The Uganda Coalition for Access to Essential Medicine (UCAEM) has asked government to withdraw and cease use of non-film coated tenofovir and lamivudine, dubbing the drug combination as notoriously bitter. (Source: AllAfrica News: HIV-Aids and STDs)
Uganda: TASO Loses Donor Funding
[Observer]The Aids Support Organization (Taso) has begun a campaign to internally solicit funds for its activities, after a Usaid project closed in June. (Source: AllAfrica News: HIV-Aids and STDs)
Consumer Information on: Pleximmune - H130004
Pleximmune is a laboratory blood test that aids in the prediction of the risk of a transplant rejection, known as Acute Cellular Rejection (ACR) in patients under 21 years who have undergone liver or small bowel transplants. (Source: Food and Drug Adminstration (FDA): CDRHNew)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Neuroscience: Music training aids speech processing
Nature 513, 7517 (2014). doi:10.1038/513147c The more music training children receive, the better their brains become at distinguishing between similar speech sounds.Nina Kraus at Northwestern University in Evanston, Illinois, and her colleagues studied children aged six to nine years from low-income neighbourhoods in Los Angeles, California, who took part (Source: Nature)
Causes of death among females-investigating beyond maternal causes: a community-based longitudinal study
Conclusions: Communicable diseases are continued to be the leading causes of death among all age females. HIV/AIDS and tuberculosis were the major causes of death among women of reproductive age. Together with existing efforts to prevent pregnancy and childbirth related deaths, public health and curative interventions on other causes, particularly on HIV/AIDS and tuberculosis, should be strengthened. (Source: BMC Research Notes)
Cryptococcus inositol utilization modulates the host protective immune response during brain infection
Conclusions: Since capsule has been shown to impact the host response during Cryptococcus-host interactions, our results suggest that the reduced GXM production may contribute to the increased immune activation in the mutant-infected animals. (Source: Cell Communication and Signaling)
Prevalence and correlates of cytopenias in HIV-infected adults initiating highly active antiretroviral therapy in Uganda
Background: Cytopenias are the most common HIV-associated hematological abnormality. Cytopenias have been associated with several factors including sex, race/ethnicity, geographical location and comorbidities such as tuberculosis, hepatitis B infection, fever and oral candidiasis. Cytopenias become more prevalent as HIV progresses and are often fatal. Data from resource-limited settings about the prevalence and correlates of cytopenia are limited. Therefore we conducted this cross-sectional study to assess the prevalence and correlates of cytopenia among adult AIDS patients at initiation of HAART in Uganda. Methods: 400 HIV-infected subjects who were HAART-naive or on HAART for (Source: BMC Infectious Diseases)
The pathogenesis of human cytomegalovirus
Abstract Human cytomegalovirus (HCMV) is a recognised cause of disease in the fetus, the allograft recipient and AIDS patients. More recently, it has been recognised as a pathogen for those admitted to intensive care units, for the elderly and for the general population. The epidemiology and molecular and cellular pathology of this virus are summarised to provide an overarching model of pathogenesis able to account for these varying clinical presentations. In brief, HCMV has the potential to spread in the bloodstream to all organs, but only produces overt disease if the viral load increases to high levels. This is normally prevented by a robust immune response, so that the infected individual usually remains asymptomatic. However, this benefit comes at the cost of committing more and more ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Steroidogenesis in MA-10 Mouse Leydig Cells Is Altered via Fatty Acid Import into the Mitochondria.
Authors: Rone MB, Midzak AS, Martinez-Arguelles DB, Fan J, Ye X, Blonder J, Papadopoulos V Abstract Mitochondria are home to many cellular processes, including oxidative phosphorylation and fatty acid metabolism, and in steroid synthesizing cells, they are involved in cholesterol import and metabolism, which is the initiating step in steroidogenesis. The formation of macromolecular protein complexes aids in the regulation and efficiency of these mitochondrial functions, though due to their dynamic nature, they are hard to identify. To overcome this problem, we used Blue-Native polyacrylamide gel electrophoresis (BN-PAGE) with whole-gel mass spectrometry on isolated mitochondria from control and hormone-treated MA-10 mouse tumor Leydig cells. The presence of multiple mitochondrial p...
Selection of Unadapted, Pathogenic SHIVs Encoding Newly Transmitted HIV-1 Envelope Proteins.
Authors: Del Prete GQ, Ailers B, Moldt B, Keele BF, Estes JD, Rodriguez A, Sampias M, Oswald K, Fast R, Trubey CM, Chertova E, Smedley J, LaBranche CC, Montefiori DC, Burton DR, Shaw GM, Markowitz M, Piatak M, KewalRamani VN, Bieniasz PD, Lifson JD, Hatziioannou T Abstract Infection of macaques with chimeric viruses based on SIVMAC but expressing the HIV-1 envelope (Env) glycoproteins (SHIVs) remains the most powerful model for evaluating prevention and therapeutic strategies against AIDS. Unfortunately, only a few SHIVs are currently available. Furthermore, their generation has required extensive adaptation of the HIV-1 Env sequences in macaques so they may not accurately represent HIV-1 Env proteins circulating in humans, potentially limiting their translational utility. We devel...
Cutaneous complications in osseointegrated implants: comparison between classic and tissue preservation techniques.
CONCLUSION: In our experience the tissue preservation technique, without soft tissue reduction, is the procedure of choice for bone anchored implant surgery. The preservation technique is easier, faster and possible with local anaesthesia and has similar postoperative outcomes. PMID: 25218328 [PubMed - as supplied by publisher] (Source: Acta Otorrinolaringologica Espanola)
Cryptococcus inositol utilization modulates the host protective immune response during brain infection
Conclusions: Since capsule has been shown to impact the host response during Cryptococcus-host interactions, our results suggest that the reduced GXM production may contribute to the increased immune activation in the mutant-infected animals. (Source: Cell Communication and Signaling)
2014 State HIV Prevention Progress Report
This is the first annual report highlighting state-level baseline information on six HIV prevention and care indicators, the national estimates, and the 2015 national goals. (Source: CDC HIV/AIDS Prevention)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Engaging Patients in Healthcare Aids Outcomes, Cuts Costs
WASHINGTON (MedPage Today) -- Getting patients more actively involved in their healthcare not only improves their health but is also cost-effective, researchers said. (Source: MedPage Today Public Health)
What are you excited about in the fight against HIV/AIDS?
Lawrence Stallworth: What are you excited about in the fight against HIV/AIDS? Submitted by Emily on Tue, 09/09/2014 - 12:16 When I was 17 years old, I found out I was HIV-positive. As a young, Black gay man, I remember the fear of rejection, and the incredible love and support I found among my family and friends. Since the day I first learned my HIV status, I have made it my personal responsibility to fight this disease until we achieve an AIDS-free generation. I know many young people out there feel the same because our risk of infection is high and access to treatment and care can be tenuous. Share Email Print var switchTo5x = false;var __st_loadLate = true;stLight.options({"publisher":"dr-e0d16a36-b72f-d979...
Kathie Hiers: What are you excited about in the fight against HIV/AIDS?
We have made amazing advances in the field of HIV in the last 33 years.  Everyone knows how much better the medications are.  Antiretroviral therapy (ART) today has fewer side effects, reduced pill burdens, and better efficacy.  And then our world was turned upside down by the incredible discovery of HIV Prevention Trials Network 052!  We now know that persons living with HIV who are successful on and adherent to ART and who reach an undetectable viral load essentially cannot transmit the disease to others.  As a result, providers are scrambling to make sure that folks know their status, that all positive persons have access to medications, and that we help people to succeed in medical care. This last and critical step, helping patients to succeed on their medications, requires a lot ...
Kathie Hiers
CEOKathie Hiers has been active in the fight against HIV/AIDS since the epidemic first hit the South in the mid-1980?s. Kathie has served as the CEO of AIDS Alabama since January 2002.  Prior to that, she was the Executive Director of Mobile AIDS Support Services and a founder of the Lee Simmons Fund for People Living with AIDS in Mobile, Alabama. Kathie is one of 25 people appointed to the Presidential Advisory Council on HIV/AIDS, providing advice and expertise to the President and the Secretary of Health and Human Services. She is also a member of the Planning Committee for the White House Summit on HIV and the South to be held in the spring of 2014. Kathie is President of the National AIDS Housing Coalition, and Co-Chair of the Federal AIDS Policy Partnership. She also serves on t...
Bill Arnold: What are you excited about in the fight against HIV/AIDS?
In this week?s Conversations Blog, I?m outlining some of the points that I find most salient in our continuing fight against HIV/AIDS in the United States. First and foremost, it is imperative that we continue to strive for an effective ?cure? (Sustained Virologic Response ? SVR ? in this case to Antiretroviral Therapies) beyond that which we currently consider to be the standard (?Undetectable? Viral Load). While suppressing the Viral Load in HIV patients is essential to ensuring that they maintain good health, it is also a vital tool in helping to prevent the spread of HIV between serodiscordant sexual partners. While there have been several reports, in recent years, of patients in various nations and circumstances being ?effectively cured,? all of these ?cures? r...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Bill Arnold
Founding DirectorWilliam ''Bill'' Arnold is a longtime HIV/AIDS activist and consumer organizer and has been active in developing HIV/AIDS organizations and HIV/AIDS policy at the local, state and national level since the mid 1980?s. Arnold is a founding director (1996) of the Community Access National Network (CANN), formerly the Ryan White CARE Act Title II Community AIDS National Network (TIICANN); he is currently its CEO. He is also a founder (1995) of The National ADAP Working Group, a Washington, DC based advocacy coalition of HIV/AIDS organizations. His involvement with grassroots HIV/AIDS work has included roles from Board Chair and Board Member, to ?Buddy? to AIDS Educator, Community Outreach Director, & pre & post test HIV Counselor. Arnold has testified on HIV/AID...
Lawrence Stallworth: What are you excited about in the fight against HIV/AIDS?
When I was 17 years old, I found out I was HIV-positive. As a young, Black gay man, I remember the fear of rejection, and the incredible love and support I found among my family and friends. Since the day I first learned my HIV status, I have made it my personal responsibility to fight this disease until we achieve an AIDS-free generation. I know many young people out there feel the same because our risk of infection is high and access to treatment and care can be tenuous. In the United States, 39 percent of all new HIV cases are among young people ages 13-29, and from 2007-2010, ages 15-19 and 20-24 were the only age groups to experience an increase in the rate of diagnoses of HIV infection. Furthermore, a young black gay man has nearly a one in four chance of becoming infected by age 25...
Lawrence Stallworth
Mobile Health Services SpecialistLawrence Stallworth is currently the Mobile Health Services Specialist at the AIDS Taskforce of Greater Cleveland.  He is an alum of Advocates for Youth?s Ohio Youth Council and was recently appointed to join the President?s Advisory Council on HIV/AIDS (PACHA) because of his exemplary local and national advocacy work on behalf of young people.  AIDSTaskforceGCAIDSTaskforceGCConversations ContributorsCompany:&nbsp;AIDS Taskforce: Greater Cleveland (Source: PHRMA)
Funding Announcement
FOA PS15-1502 Comprehensive High-Impact HIV Prevention Projects for Community-Based Organizations. (Source: CDC HIV/AIDS Prevention)
Lens Blog: A Witness to AIDS in South Africa
Joao Silva has watched South Africa?s response to the H.I.V./AIDS pandemic go from denial to ensuring those afflicted by the virus get the treatment and medications they need. (Source: NYT Health)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Nigeria: Edo Sets Up Management Team On HIV/Aids
[Daily Independent]Edo State Government has inaugurated the state Management Team (SMT) on HIV/AIDS with a charge to reduce HIV/AIDS prevalence. Secretary to the State Government, Prof. Julius Ihonvbere, who performed the inauguration, tasked the members to provide annual report on HIV activities in the state. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: Bauchi Records Decline in HIV/Aids Cases
[Daily Independent]Bauchi -Bauchi State Governor, Isa Yuguda, has declared that HIV/AIDS scourge has reduced to 0.6 per cent from the worrying 6.8 per cent that it was 13 years ago in the state. (Source: AllAfrica News: HIV-Aids and STDs)
Ongoing Impact of HIV Infection on Mortality among Persons who Inject Drugs Despite Free Antiretroviral Therapy
ConclusionsHIV infection continues to have a persistent impact on mortality rates among persons who inject drugs in settings with free HIV/AIDS care, though causes of death have shifted markedly from infectious and AIDS?related causes to non?AIDS?related etiologies. (Source: Addiction)
Isolation and characterization of non tuberculous mycobacteria from humans and animals in Namwala District of Zambia
Conclusion: The isolation of NTM from humans and animals at the interface in Namwala district has highlighted the clinical significance and diagnostic challenge. The epidemiological investigation of NTM in the study area is therefore recommended. This should include sampling from environmental sources such as water and soil. (Source: BMC Research Notes)
Measuring social support in patients with advanced medical illnesses: An analysis of the Duke-UNC Functional Social Support Questionnaire.
Authors: Saracino R, Kolva E, Rosenfeld B, Breitbart W Abstract Objective: To date, no measure of social support has been developed specifically for either palliative care or oncology settings. The present study examined the psychometric properties of the Duke-University of North Carolina Functional Social Support Questionnaire (DUFSS) in order to (1) assess the adequacy of the scale in the context of severe medical illness and (2) evaluate whether a brief subset of items might generate roughly comparable utility. Method: The 14-item DUFSS was administered to 1,362 individuals with advanced cancer or AIDS. Classical test theory (CTT) and item response theory (IRT) analyses were utilized to develop an abbreviated version of the DUFSS that maintained adequate reliability and validity...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Nocturnal snoring sound analysis in the diagnosis of obstructive sleep apnea in the Chinese Han population.
CONCLUSIONS: This new method for identifying OSA by analyzing snoring is feasible and reliable in the Han population. The snoring sound-based technique appears to be a promising tool for OSA screening and diagnosis. PMID: 25201558 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)
Nocturnal snoring sound analysis in the diagnosis of obstructive sleep apnea in the Chinese Han population
Conclusions This new method for identifying OSA by analyzing snoring is feasible and reliable in the Han population. The snoring sound-based technique appears to be a promising tool for OSA screening and diagnosis. (Source: Sleep and Breathing)
Long-term Exposure to Tenofovir and Renal Function in HIVLong-term Exposure to Tenofovir and Renal Function in HIV
Does long-term use of tenofovir disoproxil fumarate (TDF) in HIV treatment affect renal function? AIDS (Source: Medscape Today Headlines)
Control of Dyslipidemia and Hypertension in HIV OutpatientsControl of Dyslipidemia and Hypertension in HIV Outpatients
Patients with HIV may have an increased risk of cardiovascular disease. What are the best ways to control CVD risk factors in HIV patients? JAIDS: Journal of Acquired Immune Deficiency Syndromes (Source: Medscape Today Headlines)
Africa: First Hurdle for Regional Proposal Passed By EECA Union of People Living With HIV
[GFO]Proposal would earmark $7 million for regional effort to promote more domestic financing for HIV treatment (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Africa: Global Fund Promotes New Approach to Sustainability With EECA Investment Guidance
[GFO]Guidance seeks to encourage domestic financing to ensure programs continue beyond the life of Global Fund grants (Source: AllAfrica News: HIV-Aids and STDs)
Africa: Confusion Over Terminology May Hamper Domestic Resource Mobilization
[GFO]"Over-allocated" and "significantly over-allocated" not well understood (Source: AllAfrica News: HIV-Aids and STDs)
South Africa: TAC Members Form Home-Based Care Organisation
[Health-e]Member of the AIDS lobby organisation the Treatment Action Campaign (TAC) have formed a home-based care organisation to help increase communities' knowledge about HIV treatment east of Johannesburg. (Source: AllAfrica News: HIV-Aids and STDs)
Zambia: Kapiri in 'Bumper' Condom Supply
[Times of Zambia]The District AIDS Task Force (DATF) in Kapiri Mposhi has received 684,000 pieces of male condoms for mass distribution to the community in the area. (Source: AllAfrica News: HIV-Aids and STDs)
Tanzania: Policies Needed for Youth Living With HIV/Aids - Activists
[Daily News]PEOPLE living with HIV/AIDS are appealing to government to formulate clear policies to raise awareness on their rights. The Secretary of the Council for People Living with HIV/AIDS (KONGA) in Ilala Municipality, Ms Mariam Magafu made the plea in Dar es Salaam on Friday, while closing a three-day training on reproductive health for the youth living with HIV/AIDS, aged between 14 and 35 years. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Improving Access To Malaria Medicine Through Private-Sector Subsidies In Seven African Countries [Access To Drugs]
Improving access to quality-assured artemisinin combination therapies (ACTs) is an important component of malaria control in low- and middle-income countries. In 2010 the Global Fund to Fight AIDS, Tuberculosis, and Malaria launched the Affordable Medicines Facility&mdash;malaria (AMFm) program in seven African countries. The goal of the program was to decrease malaria morbidity and delay drug resistance by increasing the use of ACTs, primarily through subsidies intended to reduce costs. We collected data on price and retail markups on antimalarial medicines from 19,625 private for-profit retail outlets before and 6&ndash;15 months after the program&rsquo;s implementation. We found that in six of the AMFm pilot programs, prices for quality-assured ACTs decreased by US$1.28&ndash;$4.34, and...
Tuberculosis Drugs Better Absorbed on an Empty StomachTuberculosis Drugs Better Absorbed on an Empty Stomach
A new technique that measures blood concentrations of drugs from dried test strips shows tuberculosis treatments have better pharmacokinetic properties when taken while fasting. Medscape Medical News (Source: Medscape Hiv-Aids Headlines)
Satisfaction of HIV patients with pharmaceutical services in South Eastern Nigerian hospitals
Conclusion HIV patients were highly satisfied with services rendered by the pharmacists in South-Eastern HIV clinics in Nigeria and PSPS proved to be a reliable and valid instrument for measuring satisfaction of HIV patients with pharmaceutical services. (Source: International Journal of Clinical Pharmacy)
The effects of a web-based decision aid on the intention to diagnostic self-testing for cholesterol and diabetes: a randomized controlled trial
Conclusions: We found limited effects of the DAs on intention and its determinants. Although the time spent on the DAs was limited, we might assume that our DAs contain neutral information on self-testing for cholesterol and diabetes.By implementing our DAs in real life among people who probably or definitely intend to use a self-test and by assessing weblog files, we might be able to determine the effectiveness of our DAs on self-test behaviour.Dutch trial register: NTR3149. (Source: BMC Public Health - Latest articles)
[World Report] India's AIDS department merger angers activists
Activists are concerned about the Indian Government's decision to merge its AIDS control and health and welfare departments. Dinsa Sachan reports from New Delhi. (Source: LANCET)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
[Comment] Offline: the Kim Doctrine
Jim Kim is one of us. A medical doctor, he has worked in global health most of his professional life. He was co-founder, in 1987, of the innovative Partners in Health initiative. He revitalised WHO's AIDS response from 2004?06. He successfully fused the fields of global health and human rights during a long attachment?1993?2009?at Harvard. And, after a controversial period as President of Dartmouth College, he became President of the World Bank on July 1, 2012. Most of those who work in global health were stunned (and delighted) by his appointment. (Source: LANCET)
In MODERN Trial, Maraviroc Inferior to Tenofovir/FTCIn MODERN Trial, Maraviroc Inferior to Tenofovir/FTC
Dr. Paul Sax reviews results of the MODERN trial presented at AIDS 2014, which compared maraviroc with tenofovir/FTC in treatment-naive patients. Medscape HIV/AIDS (Source: Medscape Hiv-Aids Headlines)
Physical Therapy as an Adjunct Treatment for People Living with HIV/AIDS: A Provider Needs Assessment&#8211;Phase II
This article is currently available as a free download on ingentaconnect (Source: Journal of Allied Health)
South Africa: Premier Zille - Wrong - Again
[GroundUp]DA leader and Western Cape premier Helen Zille has again entered the HIV prevention arena, telling us we are failing to deal with HIV because we don't have the right approach to taking personal responsibility for sexual behaviours. (Source: AllAfrica News: HIV-Aids and STDs)
Swaziland: Bangladesh Without Borders - Reducing the Burden of HIV and Tuberculosis in Swaziland
[MSF]Arif Uddin Kazi was born near the Sundarbans, a mangrove forest almost the size of the small African country where he currently works. In Swaziland, every year this medical doctor treats hundreds of HIV/AIDS and tuberculosis patients in a clinic run by the medical humanitarian organization Médecins Sans Frontières (MSF). (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Gates Foundation Awards USD 25 Million to HIV Vaccine ResearchGates Foundation Awards USD 25 Million to HIV Vaccine Research
Oregon researchers developing a vaccine that has shown promise in preventing HIV infection in primates said they have been awarded a $25 million grant from the Bill and Melinda Gates Foundation. Reuters Health Information (Source: Medscape Medical News Headlines)
Promoting effective child development practices in the first year of life: does timing make a difference?
Conclusions: Audiovisual materials can be an effective complementary tool in programs aimed at supporting parents, particularly those dealing with their first baby. The results provide some useful insights into the differential benefits of using audiovisual aids at different times during the first year of life of the baby.Trial registration: ClinicalTrials.gov NCT02120430 (Source: BMC Pediatrics - Latest articles)
Introduction: Illicit drugs in Central Asia
Recently described as a ?hotspot? of the worldwide HIV epidemic (Thorne, Ferencic, Malyuta, Mimica, & Niemiec, 2010), Central Asia is currently facing ?the perfect storm? of the intertwined epidemics of drug use, HIV, HCV and TB (El-Bassel, Strathdee, & El Sadr, 2013). In contrast to the global decreases in HIV transmission, the HIV epidemic in Eastern Europe and Central Asia continues to grow at a pace faster than anywhere else (UNAIDS, 2014; The Global Fund to Fight AIDS, Tuberculosis and Malaria, 2014). (Source: International Journal of Drug Policy)
G.P.304: Living conditions and quality of life in adults with Duchenne muscular dystrophy ? A Danish survey
This study presents the results of a questionnaire survey in the growing Danish adult DMD population concerning daily life, social relations and perspectives on qualities of life (QOL). All Danish persons ?8years (n=80) with a confirmed clinical diagnosis of DMD according to the diagnostic criteria (ENMC 1997) were invited to participate in the study. Each individual was interviewed in his home by two professionals from the National Danish Rehabilitation Centre for neuromuscular Diseases (RCfM) about his physical ability, health, social relations and daily life using a comprehensive questionnaire.79 people accepted the invitation. Two had been treated with steroids and were excluded from the data analysis. Median age of 77 participants was 27years (18?46); 38 persons were >27years old....
G.O.14: The burden of Duchenne muscular dystrophy: An international, cross-sectional study
Following the substantial unmet medical need, there has been great interest in recent years to develop novel therapies for Duchenne muscular dystrophy (DMD). As the process for reimbursement of therapies requires evidence of the economic context of the disease, we performed a study to estimate the economic burden of DMD. Patients from Germany, Italy, UK, and US were identified through TREAT-NMD registries and invited to complete a questionnaire online together with a caregiver. Healthcare use, quality of life, work status, informal care, and household expenses data were collected to estimate costs of DMD from the perspective of society and caregiver households. A total of 770 patients (173 German, 122 Italian, 191 UK, and 284 US) completed the questionnaire. DMD care was associated with in...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Triple-Combination HIV Pill Triumeq Approved in EuropeTriple-Combination HIV Pill Triumeq Approved in Europe
Triumeq combines an integrase strand transfer inhibitor (dolutegravir, 50 mg) with 2 nucleoside reverse transcriptase inhibitors (abacavir, 600 mg, and lamivudine, 300 mg). International Approvals (Source: Medscape Hiv-Aids Headlines)
An evaluation of the survival rates of extra-oral implants used to retain over 200 facial prostheses over a 10 year period
This study uses data from the largest series in Europe to evaluate how significant anatomical sites and adjunctive treatments affect the overall survival. (Source: The British Journal of Oral and Maxillofacial Surgery)
Poor patients in India facing HIV/AIDS drug shortages
MUMBAI/NEW DELHI (Reuters) - Indian HIV patient Rekha has missed her daily dose of medicine several times over the last few months because the government distribution center at New Delhi's Lok Nayak Hospital ran out of drugs. (Source: Reuters: Health)
Malawi: 'Hiv & Aids Bill Not Ready for Presentation to Parliament'
[Malawi News Agency]Lilongwe -In a bid to address some contentious issues in the draft HIV and AIDS Prevention and Management Bill, Capital Hill has said it will not submit the bill to Parliament during the September meeting as was expected. (Source: AllAfrica News: HIV-Aids and STDs)
Levels of circulating myeloid subpopulations and of heme oxygenase-1 do not predict CD4(+) T cell recovery after the initiation of antiretroviral therapy for HIV disease.
Authors: Seu L, Ortiz GM, Burt TD, Deeks SG, Martin JN, McCune JM Abstract The level (or frequency) of circulating monocyte subpopulations such as classical (CD14(hi)CD16(-)) and non-classical (CD14(dim)CD16(+)) monocytes varies during the course of HIV disease progression and antiretroviral therapy (ART). We hypothesized that such variation and/or differences in the degree to which these cells expressed the immunoregulatory enzyme, heme oxygenase-1 (HO-1), would be associated with CD4(+) T cell recovery after the initiation of ART. This hypothesis was tested in a cross-sectional study of four groups of HIV-infected subjects, including those who were seronegative, untreated virologic controllers [detectable viral load (VL) of &lt;1000 copies/mL], untreated virologic non-controllers...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
India battles HIV/AIDS drug shortage as some firms halt supply
India had the third-largest number of people living with HIV in the world at the end of 2013 and accounts for about four out of 10 people living with HIV in the Asia. (Source: The Economic Times)
Southern Africa: Southern Africa's Migration Burden
[The Herald]Labour migration, a historical phenomenon across the Southern African region, has always come with unique dynamics, challenges and opportunities across social, economic and political spectrums.The emergence of HIV has presented a new and potent challenge as migrant workers have fuelled the spread of the virus, which causes AIDS. (Source: AllAfrica News: HIV-Aids and STDs)
Workplace well?being: Healing wounds or applying Band?Aids?
(Source: International Journal of Mental Health Nursing)
Baseline CD4+ T Cell Counts Correlates with HIV-1 Synonymous Rate in HLA-B*5701 Subjects with Different Risk of Disease Progression
by Melissa M. Norström, Nazle M. Veras, Wei Huang, Mattia C. F. Proper, Jennifer Cook, Wendy Hartogensis, Frederick M. Hecht, Annika C. Karlsoon, Marco Salemi HLA-B*5701 is the host factor most strongly associated with slow HIV-1 disease progression, although risk of progression may vary among patients carrying this allele. The interplay between HIV-1 evolutionary rate variation and risk of progression to AIDS in HLA-B*5701 subjects was studied using longitudinal viral sequences from high-risk progressors (HRPs) and low-risk progressors (LRPs). Posterior distributions of HIV-1 genealogies assuming a Bayesian relaxed molecular clock were used to estimate the absolute rates of nonsynonymous and synonymous substitutions for different set of branches. Rates of viral evolution, as well as in ...
In?utero infection with HIV?1 associated with suppressed lymphoproliferative responses at birth
Summary In?utero exposure to HIV?1 may affect the immune system of the developing child and may induce HIV?1?specific immune responses, even in the absence of HIV?1 infection. We evaluated lymphoproliferative capacity at birth among 40 HIV?1?uninfected infants born to HIV?1?infected mothers and 10 infants who had acquired HIV?1 in utero. Cord blood mononuclear cells were assayed using [3H]?thymidine incorporation for proliferation in response to HIV?1 p55?gag and the control stimuli phytohaemagglutinin (PHA), Staphylococcus enterotoxin B (SEB) and allogeneic cells. In response to HIV?1 p55?gag, eight (20%) HIV?1?exposed, uninfected (EU) infants had a stimulation index (SI) ??2 and three (30%) in?utero?HIV?1 infected infants had SI ?2. The frequ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
The RAB5?GEF Function of RIN1 Regulates Multiple Steps During Listeria monocytogenes Infection
Listeria monocytogenes is a food?borne pathogenic bacterium that invades intestinal epithelial cells through a phagocytic pathway that relies on the activation of host cell RAB5 GTPases. Listeria monocytogenes must subsequently inhibit RAB5, however, in order to escape lysosome?mediated destruction. Relatively little is known about upstream RAB5 regulators during L. monocytogenes entry and phagosome escape processes in epithelial cells. Here we identify RIN1, a RAS effector and RAB5?directed guanine nucleotide exchange factor (GEF), as a host cell factor in L. monocytogenes infection. RIN1 is rapidly engaged following L. monocytogenes infection and is required for efficient invasion of intestinal epithelial cells. RIN1?mediated RAB5 activation later facilitates the fusion of phagos...
Who Leaves the Hospital Against Medical Advice in the Orthopaedic Setting?
CONCLUSIONS: Our data can be used to promptly identify orthopaedic inpatients at higher risk of self-discharge on admission and target interventions to optimize treatment adherence. Strategies to enhance physician communication skills among patients with low health literacy, improve cultural sensitivity, and proactively address substance abuse issues early during hospital admission may aid in preventing discharge dilemmas and merit additional study. LEVEL OF EVIDENCE: Level III, prognostic study. See the Instructions for Authors for complete description of levels of evidence. PMID: 25187333 [PubMed - as supplied by publisher] (Source: Clinical Orthopaedics and Related Research)
Central African Republic: HIV/Aids - Conflict in Central African Republic Disrupts Treatment
[UNHCR]Bangui, Central African Republic -Conflict forced Nayo to flee her native South Sudan and seek shelter in neighbouring Central African Republic, but it has not prevented the 58-year-old refugee from receiving the medical treatment that keeps her alive. (Source: AllAfrica News: HIV-Aids and STDs)
Uganda: Ugandan Teenagers Born With HIV
[RNW Africa]For many sexually active young people, HIV/AIDS is a threat, an infectious, potentially lethal disease they should protect themselves against. But what if you were born with HIV? (Source: AllAfrica News: HIV-Aids and STDs)
South Africa: Soweto Clinic Hit By Nationwide HIV Medication Stock Out
[Health-e]Soweto's Mofolo Clinic has been hit by a nationwide stock out of a drug needed to prevent HIV infection in babies. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
South Sudan: Overcrowding at Juba Camps for Displaced Sparks Fears of HIV Outbreak
[Sudan Tribune]Juba -Overcrowding in camps for internally displaced people (IDPs) in South Sudan's capital, Juba, is exposing young people sheltering at the sites to the risk of HIV/AIDs. (Source: AllAfrica News: HIV-Aids and STDs)
Malawi: Manad Train HTC Counselors in Sign Language
[Malawi News Agency]Nsanje -Malawi National Association of the Deaf (MANAD) has embarked on an initiative aimed at imparting knowledge and skills to HIV/Aids Testing and Counseling (HTC) councilors on sign language in an attempt to improve accessibility to HIV testing and counseling services by people with hearing impairment. (Source: AllAfrica News: HIV-Aids and STDs)
Zambia: FQM Wins U.S Peace Corps Kudos
[Times of Zambia]THE United States Peace Corps has praised First Quantum Minerals (FQM) for the support rendered to the 2014 Camp ELITE a programme designed for young boys in North-Western Province, to be enlightened on issues of HIV/AIDS, gender equality, leadership and goal-setting. (Source: AllAfrica News: HIV-Aids and STDs)
Uganda: Circumcision Promoting Risky Behaviour - Report
[Observer]A new study of 314 female sex workers (FSWs) in Makindye division found that more than half of respondents falsely believe that once a man is circumcised, protection is not necessary during sex. (Source: AllAfrica News: HIV-Aids and STDs)
Uganda: Comedians in Drive Against Aids
[Observer]Barbara Kemigisa, who contracted HIV at a young age, isn't shy talking about her tragic life. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Osteoporosis and fractures in HIV/hepatitis C virus coinfection: a systematic review and meta-analysis
Conclusion:HIV/HCV coinfection is associated with a greater risk of osteoporosis and fracture than HIV monoinfection; fracture risk is even greater than uninfected controls. These data suggest that HIV/HCV-coinfected individuals should be targeted for fracture prevention through risk factor modification at all ages and DXA screening at age 50. (Source: AIDS)
Leaky gut -- A source of non-AIDS complications in HIV-positive patients
(Case Western Reserve University) Human immunodeficiency virus infection is no longer a fatal condition, thanks to newer medications inhibiting the retrovirus, but a phenomenon has surfaced among these patients -- non-AIDS complications. Scientists at Case Western Reserve University School of Medicine have resolved the mystery with their discovery of the leaky gut as the offender. Bacterial products seep out of the colon, trigger inflammation and set off the processes of cardiovascular, neurodegenerative, chronic kidney and metabolic diseases, and cancer. (Source: EurekAlert! - Medicine and Health)
Update on the key developments of the neurologic complications in children infected with HIV.
Authors: Wilmshurst JM, Donald KA, Eley B Abstract PURPOSE OF REVIEW: To discuss recent research findings of neurologic complications in HIV-infected children, specifically addressing neuroinfections, cerebrovascular disease, epilepsy and neurocognitive complications. The range of neurologic childhood onset complications is diverse and often overlaps diseases previously considered only to manifest in adults. In the pediatric population, these complications frequently have their own unique disease identity, which may be related to maturational patterns evident in the developing brain. RECENT FINDINGS: Developments regarding the pathogenesis of neuroAIDS, treatment of tuberculous meningitis and prevention of bacterial meningitis are described. With the advent of neuroimaging, the...
Cement arthroplasty for ankle joint destruction.
CONCLUSIONS: Primary cement arthroplasty might be a treatment option for advanced ankle destruction in elderly and less active patients. LEVEL OF EVIDENCE: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence. PMID: 25187586 [PubMed - in process] (Source: The Journal of Bone and Joint Surgery. American volume)
The link between CD8+ T-cell antigen-sensitivity and HIV-suppressive capacity depends on HLA restriction, target epitope and viral isolate: Erratum
No abstract available (Source: AIDS)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
South Africa: Shortage of Drug That Prevents Babies From Getting HIV
[GroundUp]The National Department of Health (NDoH) has sent out a circular nationally to all doctors, nurses and pharmacists informing them of a shortage of a paediatric anti-AIDS drug called nevirapine, used to prevent HIV infection in the newborn children of mothers with HIV. (Source: AllAfrica News: HIV-Aids and STDs)
South Sudan: One Child's Story of Living With HIV in a South Sudan Camp
[Key Correspondents]Puack, aged 4, is living with HIV and has been under the care of his stepmother Martha since his mother died of AIDS in 2012. (Source: AllAfrica News: HIV-Aids and STDs)
Single pill 'aids heart patients'
Heart attack survivors given multiple pills instead of one are less likely to follow treatment regimes - putting themselves at risk of a repeat attack, a new study suggests. (Source: Nursing Times Breaking News)
Nigeria: Agency Intensifies HIV/Aids Awareness Campaign in Nasarawa
[Daily Independent]Lafia -Nasarawa State AIDS Control Agency (NASACA) has commenced what it described as a "10-day intensive house -to- house campaign" on HIV/AIDS in the state that is targeting about half a million sexually active persons. (Source: AllAfrica News: HIV-Aids and STDs)
Genders of patients and clinicians and their effect on shared decision making: a participant-level meta-analysis
Conclusions: In this participant-level meta-analysis of 7 randomized trials, decision aids used at the point of care demonstrated comparable efficacy across gender dyads. Purported barriers to shared decision making based on gender were not detected when tested for a minimum detected difference.Trial registrations: ClinicalTrials.gov NCT00888537, NCT01077037, NCT01029288, NCT00388050, NCT00578981, NCT00949611, NCT00217061. (Source: BMC Medical Informatics and Decision Making - Latest articles)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Label-free probe of TAT peptide binding to vesicles [Biophysics and Computational Biology]
The transacting activator of transduction (TAT) protein plays a key role in the progression of AIDS. Studies have shown that a +8 charged sequence of amino acids in the protein, called the TAT peptide, enables the TAT protein to penetrate cell membranes. To probe mechanisms of binding and translocation of... (Source: Proceedings of the National Academy of Sciences)
HIV-2 and HTLV-1 Infections in Spain, a Non-Endemic Region.
Authors: de Mendoza C, Caballero E, Aguilera A, Pirón M, Ortiz de Lejarazu R, Rodríguez C, Cabezas T, González R, Treviño A, Soriano V Abstract The annual workshop of the Spanish HIV?2/HTLV Study Group was held at the Instituto de Salud Carlos III in Madrid on December 11, 2013. Nearly 100 experts and researchers in retroviruses other than HIV?1, the classical AIDS agent, convened for a one?day meeting devoted to updating knowledge on the epidemiology of HIV?2 and HTLV-1 infections and discussing new diagnostic and therapeutic strategies, with special attention to non?endemic regions such as Spain. The Group was funded 25 years ago and since then has been responsible for the national registry of cases, recording all relevant information for each subject and inviting t...
Effect of SAHA administration on the residual virus pool in a model of combination antiretroviral therapy-mediated suppression in SIVmac239-infected Indian rhesus macaques.
Authors: Del Prete GQ, Shoemaker R, Oswald K, Lara A, Trubey CM, Fast R, Schneider DK, Kiser R, Coalter V, Wiles A, Wiles R, Freemire B, Keele BF, Estes JD, Quiñones OA, Smedley J, Macallister R, Sanchez RI, Wai JS, Tan CM, Alvord WG, Hazuda DJ, Piatak M, Lifson JD Abstract Non-human primate models are needed for evaluations of proposed strategies targeting residual virus that persists in HIV-1 infected individuals receiving suppressive combination antiretroviral therapy (cART). However, relevant NHP models of cART-mediated suppression have proven challenging to develop. We used a novel three class, six drug combination antiretroviral therapy (cART) regimen to achieve durable 4.0-5.5 log reductions in plasma viremia and declines in cell associated viral RNA and DNA in blood and ti...
The invertebrate midintestinal gland (?hepatopancreas?) is an evolutionary forerunner in the integration of immunity and metabolism
Abstract The immune system has an impact on the metabolic performance in vertebrates, thus the metabolic effects of immune cells are receiving intense attention today in the biomedical field. However, the evolutionary origin of the immunity?metabolism interaction is still uncertain. In this review, I show that mollusks and crustaceans integrate immune functions to a metabolic organ, the midintestinal gland (?hepatopancreas?). In these animals, the epithelial cells of the midintestinal gland are major sources of immune molecules, such as lectins, hemocyanin, ferritin, antibacterial and antiviral proteins, proteolytic enzymes and nitric oxide. There is crosstalk between midintestinal gland cells and phagocytes, which aids the initiation of the immune response and the clearance...
Africa: Global Fund News Flash - Issue 48
[Global Fund]Better Concept Notes, More Effective Funding (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Kenya: First Lady Urges Homa Bay to Fight HIV-Aids
[The Star]FIRST lady Margaret Kenyatta has urged fishermen and fishmongers to change their lifestyles in order to stop the spread of HIV-Aids. (Source: AllAfrica News: HIV-Aids and STDs)
Uganda: Universal Net Campaign Completed in Uganda, With US, UK and Global Fund Support
[Global Fund]Kampala -The U.S. Government, the United Kingdom (U.K.) Government and the Global Fund to Fight AIDS, Tuberculosis and Malaria sealed their commitment to the fight against malaria in Uganda today by finalizing their contribution to the Government of Uganda's Universal Coverage Campaign. Over 22 million long-lasting insecticide-treated nets (LLINs) for malaria prevention were distributed under the campaign, the largest universal coverage campaign worldwide, which began in the eastern part of the country and extended (Source: AllAfrica News: HIV-Aids and STDs)
Africa: Global Fund News Flash - Issue 47
[Global Fund]Zambia: Power of Partnerships (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: Medical Researcher Decries Low Patronage of HIV Prevention Services
[Leadership]A medical researcher, Prof. Oni Idigbe, on Friday expressed concern over the public's low patronage of Prevention of Mother-to-Children Transmission of HIV (PMTCT) services in Nigeria. (Source: AllAfrica News: HIV-Aids and STDs)
Arab Region Has World?s Fastest Growing HIV Epidemic
By Mona AlamiBEIRUT, Sep 1 2014 (IPS)At a time when HIV rates have stabilised or declined elsewhere, the epidemic is still advancing in the Arab world, exacerbated by factors such as political unrest, conflict, poverty and lack of awareness due to social taboos.According to UNAIDS (the Joint United Nations Programme on HIV/AIDS), an estimated 270,000 people were living with human immunodeficiency virus (HIV) in the countries of the Middle East and North Africa (MENA) region in 2012.?It is true that the Arab region has a low prevalence of infection, however it has the fastest growing epidemic in the world,? warns Dr Khadija Moalla, an independent consultant on human rights/gender/civil society/HIV-AIDS.With the exception of Somalia and Djibouti, the [HIV] epidemic is generally concentr...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Kenya: HIV-Aids Myths Busted
[The Star]HIV-AIDS Myths busted Many people are afraid of HIV and for good reason. (Source: AllAfrica News: HIV-Aids and STDs)
FACSCount CD4 and Pima CD4 T-Cell Count SystemsFACSCount CD4 and Pima CD4 T-Cell Count Systems
Which CD4 counting instrument is most reliable? JAIDS: Journal of Acquired Immune Deficiency Syndromes (Source: Medscape Today Headlines)
The Significance of Low-level Viraemia in Diverse SettingsThe Significance of Low-level Viraemia in Diverse Settings
This study reports on the association of low-level viraemia with viral failure in different economic settings. HIV Medicine (Source: Medscape Today Headlines)
Is Bone Loss Linked to Chronic Inflammation in HIV?Is Bone Loss Linked to Chronic Inflammation in HIV?
What role do inflammation and vitamin D play in HIV bone loss? AIDS (Source: Medscape Today Headlines)
Effectiveness of first-line antiretroviral therapy in the IPEC cohort, Rio de Janeiro, Brazil
Background: While Brazil has had a long-standing policy of free access to antiretroviral therapy (ART) for all in need, the epidemiological impact of ART on human immunodeficiency virus (HIV) RNA suppression in this middle-income country has not been well evaluated. We estimate first-line ART effectiveness in a large Brazilian cohort and examine the socio-demographic, behavioral, clinical and structural factors associated with virologic suppression. Methods: Virologic suppression on first-line ART at 6, 12, and 24 months from start of ART was defined as having a viral load measurement 8 years of formal education (compared to (Source: AIDS Research and Therapy)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Alcohol and cognitive impairment [Articles]
We present what is known about cognitive impairment associated with alcohol use/misuse, covering the spectrum from mild and subtle cognitive change through to severe alcohol-related brain damage, including Wernicke&ndash;Korsakoff syndrome. We highlight aids to the diagnosis and management of these conditions, and emphasise the benefits of prompt treatment on outcome. We also review progress in understanding their neurobiology. Suggestions for possible service configuration based on both our clinical practice and national guidelines are given. (Source: Advances in Psychiatric Treatment)
HIV-1 Nef and KSHV oncogene K1 synergistically promote angiogenesis by inducing cellular miR-718 to regulate the PTEN/AKT/mTOR signaling pathway
Kaposi's sarcoma (KS) is an AIDS-defining cancer with aberrant neovascularization caused by KS-associated herpesvirus (KSHV). Although the interaction between HIV-1 and KSHV plays a pivotal role in promoting the aggressive manifestations of KS, the pathogenesis underlying AIDS-KS remains largely unknown. Here we examined HIV-1 Nef protein promotion of KSHV oncoprotein K1-induced angiogenesis. We showed that both internalized and ectopic expression of Nef in endothelial cells synergized with K1 to facilitate vascular tube formation and cell proliferation, and enhance angiogenesis in a chicken CAM model. In vivo experiments further indicated that Nef accelerated K1-induced angiogenesis and tumorigenesis in athymic nu/nu mice. Mechanistic studies revealed that Nef and K1 synergistically activ...
The use of light?based (optical) detection systems as adjuncts in the detection of oral cancer and oral potentially malignant disorders: a systematic review
ConclusionThere is limited evidence for their use in primary care, and these tools are better suited to specialist clinics in which there is a higher prevalence of disease and where experienced clinicians may better discriminate between benign and malignant lesions. (Source: Journal of Oral Pathology and Medicine)
Hypothalamic-Pituitary-Adrenal Axis in HIV Infection and Disease.
Authors: Chrousos GP, Zapanti ED Abstract HIV infection induces hypothalamic-pituitary-adrenal (HPA) axis derangements. Partial glucocorticoid resistance has been observed in a subset of AIDS patients, possibly owing to HIV-induced altered cytokine secretion and action. Because glucocorticoids have immunomodulatory effects, the severity of the HPA axis disorder could play a central role in disease progression. The characteristic phenotype of AIDS patients (visceral obesity, lipodystrophy) may be owing to effects of HIV proteins on the HPA axis, including changes in glucocorticoid and insulin sensitivity of target tissues, as well as altered cytokine production and interaction with the HPA axis, genetic causes, comorbidities, and, possibly, use of antiretroviral agents. PMID: 25...
HIV?associated salivary gland disease ? clinical or imaging diagnosis?
ConclusionUS examination proved to be essential for the correct diagnosis and monitoring of the progression of HIV/SGD. (Source: International Journal of Paediatric Dentistry)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Quality of reporting of dental survival analyses
Summary To explore the quality of reporting (writing and graphics) of articles that used time?to?event analyses to report dental treatment outcomes. A systematic search of the top 50 dental journals in 2008 produced the sample of articles for this analysis. Articles reporting treatment outcomes with (n = 95) and without (n = 91) time?to?event statistics were reviewed. Survival descriptive words used in the two groups were analysed (Pearson's chi?square). The quality of life tables, survival curves and time?to?event statistics were assessed (Kappa analysed agreement) and explored. Words describing dental outcomes ?over time? were more common in time?to?event compared with control articles (77%, 3%, P &lt; 0·001). Non?specific use of ?rate? was common acros...
Inflectional morphology in German hearing-impaired children.
Authors: Penke M, Wimmer E, Hennies J, Hess M, Rothweiler M Abstract Despite modern hearing aids, children with hearing impairment often have only restricted access to spoken language input during the 'critical' years for language acquisition. Specifically, a sensorineural hearing impairment affects the perception of voiceless coronal consonants which realize verbal affixes in German. The aim of this study is to explore if German hearing-impaired children have problems in producing and/or acquiring inflectional suffixes expressed by such phonemes. The findings of two experiments (an elicitation task and a picture-naming task) conducted with a group of hearing-impaired monolingual German children (age 3-4 years) demonstrate that difficulties in perceiving specific phonemes relate to...
Residual Metal Impurity Aids Facile In Situ Electrochemical Surface Derivatization of Single-Walled Carbon Nanotubes.
Authors: Boopathi S, Sudha R, Senthil Kumar S, Lakshminarasimha Phani K Abstract Residual metal impurities were exploited as reactants in the functionalization of the surface of single-walled carbon nanotubes (SWCNT) with nickel hexacyanoferrate (NiHCF) by simple electrochemical cycling in ferricyanide solutions. This facile in situ electrochemical modification process provides intimate contact between NiHCF and SWCNTs that improves the stability of the redox property and reactivity of NiHCF. The characteristic redox behavior of NiHCF on SWCNT surfaces can be used as an electrochemical probe to access qualitative and quantitative information on unknown electroactive metal impurities in SWCNTs. Significantly, the NiHCF-modified SWCNTs exhibit pseudocapacitive behavior, and the calcu...
Hearing outcomes following primary malleostapedial rotation ossiculoplasty in patients undergoing modified radical mastoidectomy.
CONCLUSIONS: The improvement in hearing thresholds demonstrated in this cohort of patients supports the use of this form of ossiculoplasty in those undergoing open cavity procedures. This would also suggest that the subsequent use of hearing aids in these patients would require less amplification and therefore provide superior hearing outcomes. As hearing loss remains a significant concern following modified radical mastoidectomy, we suggest an open cavity with primary malleostapedial rotation ossiculoplasty as a viable alternative to modified radical mastoidectomy alone, in selected cases. PMID: 25198979 [PubMed - in process] (Source: Annals of the Royal College of Surgeons of England)
[EUS-FNA: How to Improve Biopsy Results? An Evidence Based Review].
In this report we briefly review the actual literature and summarize the available evidence on some controversely discussed issues. The results support the view that use of a stylet rarely aids to increase the amount of tissue obtained during EUS-FNA, whereas use of suction can be helpful in certain situations. Novel cutting needles may potentially improve number and size of core biopsies that can be rendered for special histologic tissue processing techniques. An in-room-cytopathologist not necessarily improves outcome of EUS-FNA results but may have a role during build-up of EUS units to become more successful. EUS-FNA education requires skilled endoscopists on both sides and can presumably be improved by objective testing of practical expertise by peer review and introducing objective s...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
[New possibility for measuring the cortical auditory evoked potentials: the HEARLab.]
Conclusions: The HEARLAb can be a great help when performance of the conventional audiological examinations is complicated. The examination can be performed in uncooperative subjects even in the presence of hearing aids. The test is frequency specific and does not require anesthesia. Orv. Hetil., 2014, 155(38), 1524-1529. PMID: 25217769 [PubMed - as supplied by publisher] (Source: Orvosi Hetilap)
A new paradigm for sexually transmitted infection (STI) screening in the hampton roads community of Southeastern Virginia
Southeastern Virginia has the highest rates of STIs in the State. With funding from the Elton John AIDS Foundation (EJAF), PPSEV screened 966 individuals in Hampton Roads. Objectives were to examine costs of the program compared to scheduling visits with providers; and compare time to notification of abnormal results. (Source: Fertility and Sterility)
Factors that influence intent to adopt a hearing aid among older people in Italy
Abstract Hearing loss is one of the most prevalent health impairments associated with ageing in developed countries, and it can result in social, emotional and communication dysfunction. Hearing loss in Italy is increasing, yet, despite the availability of free hearing aids and access to qualified community?based health professionals specialising in audiology services, their uptake remains low (about 15%?20%). This paper presents an investigation of the possible reasons why older people in Italy resist adopting a hearing aid. We used the literature to identify factors influencing people with hearing loss's decision?making, and drew on the theory of reasoned action to create an explanatory model. To test our hypotheses, we applied a cross?sectional design. We developed a questionnai...
?Volunteers Are Not Paid Because They Are Priceless?: Community Health Worker Capacities and Values in an AIDS Treatment Intervention in Urban Ethiopia
This article analyzes community health workers? (CHW) capacities for empathic service within an AIDS treatment program in Addis Ababa. I show how CHWs? capacities to build relationships with stigmatized people, reconcile family disputes, and confront death draw on a constellation of values, desires, and emotions encouraged by CHWs? families and religious teachings. I then examine the ways in which the capacities of CHWs were valued by the institutions that deployed them. NGO and government officials recognized that empathic care was crucial to both saving and improving the quality of people's lives. These institutional actors also defended a policy of not financially remunerating CHWs, partly by constructing their capacities as so valuable that they become ?priceless? and therefo...
Incidental Cystic Lesions in the Pancreas: Resect? EUS? Follow?
Opinion Statement Pancreatic cysts challenge clinicians due to their increased incidental identification on radiology imaging, the limitations of currently available diagnostic tools, and potential for malignancy. Following initial identification of an incidental pancreatic cyst, a dedicated pancreatic protocol abdominal CT scan or MRI pancreas with MRCP should be performed. Surgical resection is recommended for all surgical candidates with MD-IPMN, mixed or combined type IPMN, mucinous cystic neoplasm, and solid pseudopapillary neoplasm. Serous cystadenoma may be followed with serial imaging unless the patient develops symptoms, the cyst is larger than 4 cm or rapidly growing, or diagnostic uncertainty remains despite thorough evaluation. Surveillance is also recommended for BD...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Metabolic Syndrome, Diabetes, and Cardiovascular Risk in HIV
Abstract HIV infection and its treatment have been associated with adipose tissue changes and disorders of glucose and lipid metabolism. The proportion of HIV-infected adults over the age of 50 is also growing placing HIV-infected adults at particular risk for metabolic perturbations and cardiovascular disease. The metabolic syndrome in HIV-infected adults has been increasingly studied but whether HIV is associated with greater risk remains unclear, likely because of the interplay of host, viral and antiretroviral factors that are associated with the components of the metabolic syndrome. The relationship between HIV and diabetes mellitus (DM) risk has also been debated. While the Framingham Risk Score is a well-accepted measure of 10-year cardiovascular risk in the general popula...
Understanding the Etiology and Management of HIV-Associated Peripheral Neuropathy
Abstract HIV may cause several forms of peripheral neuropathy, the most common of which is distal symmetric polyneuropathy (DSP) characterized by pain and sensory deficits in a stocking-glove distribution. The pathophysiology of DSP remains largely unknown but is thought to be related both to the neurotoxicity of HIV?through indirect immunomodulatory mechanisms?and to the neurotoxic effects of anti-retroviral therapies, most notably the dideoxynucleoside reverse transcription inhibitors or so-called d-drugs. Determining whether symptoms arise from the virus or the treatment poses a challenge to the clinician who must decide if a patient?s HAART regimen should be altered. Treatment of symptoms related to HIV-DSP is a difficult task and there is no evidence that the tradition...
Bone Alterations Associated with HIV
Abstract HIV infection and initiation of antiretroviral therapy (ART) have been consistently associated with decreased bone mineral density (BMD), with growing evidence linking HIV to an increased risk of fracture. This is especially concerning with the expanding number of older persons living with HIV. Interestingly, recent data suggest that HIV-infected children and youth fail to achieve peak BMD, possibly increasing their lifetime risk of fracture. Elucidating the causes of the bone changes in HIV-positive persons is challenging because of the multifactorial nature of bone disease in HIV, including contribution of the virus, immunosuppression, ART toxicity, and traditional osteoporosis risk factors, such as age, lower weight, tobacco, and alcohol use. Thus, practitioners must ...
HIV Associated Neurocognitive Disorders in the Modern Antiviral Treatment Era: Prevalence, Characteristics, Biomarkers, and Effects of Treatment
Abstract The introduction of combination antiretroviral treatment (cART) has significantly reduced the mortality secondary to opportunistic infections in HIV patients by restoring the immune system. In the central nervous system (CNS), there has also been benefit with a marked reduction of HIV associated dementia. However, the milder forms of HIV associated neurocognitive disorder (HAND), namely asymptomatic neurocognitive impairment and mild neurocognitive disorder, remain prevalent in the cART era. In this article, we will discuss how cART interacts with HAND in terms of clinical characteristics and biomarkers. We will then review the outcomes of recent clinical studies focused on the CNS penetrating antiretroviral regimens and some novel therapeutic approaches. (Source: Curren...
Differentiating HIV-associated Nephropathy from Antiretroviral Drug-Induced Nephropathy: A Clinical Challenge
Abstract With the introduction of potent combination antiretroviral therapy (cART) into clinical practice, HIV-infected patients have garnered much benefit. However, kidney disease continues to be a potential complication in this group. Whereas HIV-associated nephropathy (HIVAN) was the major renal complication prior to cART, co-morbid diseases and adverse renal effects of various drugs, in particular cART, now complicate the landscape. Clinicians now must differentiate HIVAN from cART nephrotoxicity. While sometimes this is easy and relatively straightforward, often the clinician faces a difficult challenge distinguishing these two etiologies of kidney disease. This review will discuss HIVAN and cART-related kidney disease and review the clinical and laboratory data that may be ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Chronic Inflammation and the Role for Cofactors (Hepatitis C, Drug Abuse, Antiretroviral Drug Toxicity, Aging) in HAND Persistence
Abstract HIV-associated neurocognitive disorders (HAND) is a group of syndromes of varying degrees of cognitive impairment affecting up to 50 % of HIV-infected individuals. The neuropathogenesis of HAND is thought to be driven by HIV invasion and productive replication within brain perivascular macrophages and endogenous microglia, and to some degree by restricted infection of astrocytes. The persistence of HAND in individuals experiencing suppression of systemic HIV viral load with antiretroviral therapy (ART) is incompletely explained, and suggested factors include chronic inflammation, persistent HIV replication in brain macrophages, effects of aging on brain vulnerability, and co-morbid conditions including hepatitis C (HCV) co-infection, substance abuse, and CNS toxicity of...
Functional Impairment, Disability, and Frailty in Adults Aging with HIV-Infection
Abstract The integration of antiretroviral therapy (i.e., ART) into HIV care has dramatically extended the life expectancy of those living with HIV. However, in comparison to similar HIV-uninfected populations, HIV-infected persons experience an excess of morbidity and mortality with an early onset of aging complications including neurocognitive decline, osteoporosis, impaired physical function, frailty, and falls. Recent consensus guidelines encourage clinicians and researchers to consider functional impairment of HIV-infected adults as a measure to understand the impact of aging across a range of abilities. Despite the importance of assessing function in persons aging with HIV infection, a lack of consistent terminology and standardization of assessment tools has limited the ap...
Host Genetic Factors Predisposing to HIV-Associated Neurocognitive Disorder
Abstract The success of combination antiretroviral therapy (cART) in transforming the lives of HIV-infected individuals with access to these drugs is tempered by the increasing threat of HIV-associated neurocognitive disorders (HAND) to their overall health and quality of life. Intensive investigations over the past two decades have underscored the role of host immune responses, inflammation, and monocyte-derived macrophages in HAND, but the precise pathogenic mechanisms underlying HAND remain only partially delineated. Complicating research efforts and therapeutic drug development are the sheer complexity of HAND phenotypes, diagnostic imprecision, and the growing intersection of chronic immune activation with aging-related comorbidities. Yet, genetic studies still offer a power...
Immune Reconstitution Disorders in Patients With HIV Infection: From Pathogenesis to Prevention and Treatment
Abstract An immune reconstitution disorder occurs in up to 40 % of severely immunodeficient HIV patients who commence antiretroviral therapy (ART), with an immune reconstitution inflammatory syndrome (IRIS) being encountered most commonly. Differences in the immunopathogenesis of an IRIS associated with different types of pathogen have become apparent but common features have also been defined. These include severe immunodeficiency prior to commencing ART associated with a high pathogen load and ?compensatory? immune responses, particularly innate immune responses, which inadequately control the pathogen and increase the risk of immunopathology as the immune system recovers on ART. Prevention of an IRIS may be achieved by optimising therapy for opportunistic infections befor...
Depression and Adherence to Antiretroviral Therapy in Low-, Middle- and High-Income Countries: A Systematic Review and Meta-Analysis
In conclusion, the likelihood of achieving good adherence was lower among those with depressive symptoms compared to those without. (Source: Current HIV/AIDS Reports)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
HIV-Hepatitis C Virus Co-infection in the era of Direct-Acting Antivirals
Abstract Approximately one-third of patients infected with human immunodeficiency virus (HIV) are concomitantly infected with hepatitis C virus (HCV). As a result, liver disease remains a major source of morbidity and mortality in HIV patients. Prior to 2011, treatments of HCV lacked efficacy in clinical trials in HIV/HCV co-infected patients. Fortunately, several direct-acting antivirals (DAAs) have now entered clinical practice and others have reached advanced stages of clinical development. These therapies offer significant benefits such as improved rates of sustained virologic response (SVR), shortened durations of treatment, and compatibility with HIV antiretroviral therapies. Treatments such as sofosbuvir (SOF) have received approval for HIV/HCV co-infected patients. Moreov...
Treatment of HIV in the CNS: Effects of Antiretroviral Therapy and the Promise of Non-Antiretroviral Therapeutics
Abstract The growing recognition of the burden of neurologic disease associated with HIV infection in the last decade has led to renewed efforts to characterize the pathophysiology of the virus within the central nervous system (CNS). The concept of the AIDS-dementia complex is now better understood as a spectrum of HIV-associated neurocognitive disorders (HAND), which range from asymptomatic disease to severe impairment. Recent work has shown that even optimally treated patients can experience not only persistent HAND, but also the development of new neurologic abnormalities despite viral suppression. This has thrown into question what the impact of antiretroviral therapy has been on the incidence and prevalence of neurocognitive dysfunction. In this context, the last few years ...
Incarceration of People Living with HIV/AIDS: Implications for Treatment-as-Prevention
Abstract Contact with the criminal justice system, including incarceration, is a common experience for many people living with HIV/AIDS. Optimism has recently been expressed that correctional facilities could be important locations for treatment-as-prevention (TasP)-based initiatives. We review recent findings regarding the effect of incarceration on patterns of HIV transmission, testing, treatment initiation and retention. We found that the prevalence of HIV infection among incarcerated individuals remains higher than analogous non-incarcerated populations. Recent studies have shown that voluntary HIV/AIDS testing is feasible in many correctional facilities, although the number of previously undiagnosed individuals identified has been modest. Studies have implied enhanced linkag...
Drug Interactions and Antiretroviral Drug Monitoring
This article reviews some of the most relevant and emerging potential interactions between antiretroviral medications and other agents. The most common DDIs are those involving protease inhibitors or non-nucleoside reverse transcriptase inhibitors, which alter the cytochrome P450 enzyme system and/or drug transporters such as p-glycoprotein. Of note are the new agents for the treatment of chronic hepatitis C virus infection. These new classes of drugs and others drugs that are increasingly used in this patient population represent a significant challenge with regard to achieving the goals of effective HIV suppression and minimization of drug-related toxicities. Awareness of DDIs and a multidisciplinary approach are imperative in reaching these goals. (Source: Current HIV/AIDS Reports)
Vitamin D Deficiency and Altered Bone Mineral Metabolism in HIV-infected Individuals
Abstract Although patients with HIV infection are living decades longer than before with the advent of combination antiretroviral therapy, they have an increased rate of co-morbidities associated with chronic HIV, such as osteoporosis, cardiovascular disease, and immune dysfunction. Many of these complications are known to be affected by vitamin D status in the general population. Thus, the high rate of vitamin D deficiency among HIV-infected patients is alarming. Many observational and cohort studies have demonstrated that vitamin D deficiency is associated with these HIV-related complications, but randomized, placebo-controlled trials are limited. This paper reviews recent data on vitamin D deficiency in HIV infection. (Source: Current HIV/AIDS Reports)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
HPV and Anal Cancer in HIV-Infected Individuals: A Review
Abstract HIV infection is one of the strongest risk factors for anal squamous cell cancer (ASCC). Most ASCC are caused by HPV, and most HPV-associated ASCC are caused by HPV-16. Anal HPV infections are very common in men who have sex with men (MSM), and nearly universal among HIV-infected MSM. High-grade anal intraepithelial neoplasia (HGAIN), the precursor for ASCC, is present in about 30 % of HIV+ MSM, but neither the progression rate to ASCC nor the regression rate are known. The incidence rate of ASCC among HIV-infected people has risen in the first decade after cART became available, but appears to be plateauing recently. Anal cytology has poor sensitivity and specificity. High resolution anoscopy (HRA) is advocated by some as a screening tool in high-risk groups, but is cu...
Update on Diagnosis of Pneumocystis Pulmonary Infections
Abstract Pneumocystis jirovecii is a widespread fungal colonizer of the human lung. Proliferation of the pathogen in the alveoli is controlled by the immune system in healthy individuals. When the immune system is impaired, pneumocystosis can emerge, resulting in a pulmonary infection. Formerly, the disease occurred mainly in acquired immune deficiency syndrome (AIDS) patients, accompanied by a high mortality. Now it is increasingly seen in patients with immunosuppressive treatment. Traditionally, laboratory diagnosis is based on the microscopic detection of cysts and trophic forms of P. jirovecii in respiratory samples. Quantitative PCR-based methods will revolutionize laboratory diagnosis. However, cutoffs have to be established to discriminate between colonization ...
An 84-month observational study of the changes in CD4 T-lymphocyte cell count of 110 HIV/AIDS patients treated with traditional Chinese medicine
This study aimed to evaluate the therapeutic effect of traditional Chinese medicine (TCM) by observing the changes in CD4 T-lymphocyte cell count of 110 cases with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) treated continuously with TCM for 84 months. Information of 110 HIV/AIDS patients from 19 provinces and cities treated with TCM from 2004 to 2013 was collected. Changes in the indexes of CD4 counts ( ? 200, 201?350, 351?500 and &gt; 500 cells/mm3) at five time points (0, 12, 36, 60 and 84 months) and different treatments [TCM and TCM plus antiretroviral therapy (ART)] were compared. Repeated measures test indicated no interaction between group and time (P &gt; 0.05). Degrees of increasing and decreasing CD4 count of the two groups at four differen...
Massive expansile ossifying fibroma of the mandible with osteomyelitis
Abstract An ossifying fibroma is a benign odontogenic tumor of mesenchymal origin that belongs to the spectrum of fibro-osseous lesions afflicting the craniofacial complex. Although benign, it can be potentially aggressive, reaching very large sizes. The authors report a rare case of an aggressive ossifying fibroma in the mandible of a 30-year-old male patient that reached gigantic proportions with superimposed osteomyelitis, mimicking a malignancy. Differentiation of ossifying fibroma from other fibro-osseous lesions and benign and malignant neoplasms is important for the correct management of this lesion. Proper radiological evaluation and interpretation aids for arriving at a definitive diagnosis are required. The paper also highlights the radiological features of this entity....
Chronic binge alcohol consumption does not diminish effectiveness of continuous antiretroviral suppression of viral load in simian immunodeficiency virus-infected macaques.
CONCLUSIONS: These findings indicate that CBA does not attenuate effectiveness of NRTI suppression of viral load, nor does it appear to interact with NRTI to produce toxicity during the initial 2 months of treatment. We conclude that while efforts to reduce AUD in PLWHA should be a priority, counseling on the importance of adherence to ART even on drinking days should also be promoted. PMID: 25257285 [PubMed - in process] (Source: Alcoholism, Clinical and Experimental Research)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Cytomegalovirus Treatment
Opinion statement In treating cytomegalovirus (CMV) infection, it is crucial to decide whether one is treating pre-emptively or if one is treating established disease. Disease may be further divided into viral syndrome and tissue-invasive disease. Generally, mild disease in immunosuppressed patients may be treated with oral valganciclovir. Treatment may also be started with valganciclovir for CMV retinitis in AIDS patients. In other tissue-invasive syndromes, starting with intravenous ganciclovir or foscarnet at full doses (adjusted for renal function) is preferred. Treatment at full doses should be continued until symptom resolution and until blood antigenemia (or DNAemia) is cleared. Patients receiving treatment must be closely monitored for side effects to the drugs, as well a...
Therapy of AIDS-Related Cryptococcal Meningitis
Opinion statement Cryptococcal meningitis is a common and severe opportunistic infection in advanced HIV, with the highest burden of disease in resource-poor settings in sub-Saharan Africa. It is invariably fatal if left untreated, and carries a high mortality even with treatment. High fungal burden, raised intracranial pressure, and reduced level of consciousness at presentation are associated with poorer outcomes. The recommended treatment strategy consists of a two-week induction phase, then eight weeks of consolidation therapy, followed by long-term maintenance therapy until restoration of immune function by antiretroviral therapy (ART) for HIV. Induction treatment should consist of a rapidly fungicidal drug. Amphotericin B has demonstrated superiority to fluconazole both in ...
Antiretroviral treatment outcomes among foreign-born and Aboriginal peoples living with HIV/AIDS in northern Alberta.
CONCLUSIONS: Our study indicated that ART outcomes among Alberta-based foreign-born patients are similar to those among Canadian-born non-Aboriginal patients. Our results, however, suggested that Canadian-born Aboriginal patients had poorer treatment outcomes compared to Canadian-born non-Aboriginal patients. It is imperative, therefore, that clinicians, researchers and community members better understand reasons for poor ART outcomes among Canadian-born Aboriginal patients in northern Alberta. PMID: 25166126 [PubMed - in process] (Source: Canadian Journal of Public Health)
Patient, surgeon, and healthcare purchaser views on the use of decision and communication aids in orthopaedic surgery: a mixed methods study
Conclusions: Decision and communication aids can be effective tools for incorporating patients preferences and values into preference-sensitive decisions in orthopaedics. Future efforts should be aimed at assessing strategies for efficient implementation of these tools into widespread orthopaedic practice. (Source: BMC Health Services Research)
Cost-effectiveness Analysis Along the Continuum of HIV Care: How Can We Optimize the Effect of HIV Treatment as Prevention Programs?
Abstract The cascade of HIV care has been proposed as a useful tool to monitor health system performance across the key stages of HIV care delivery to reduce morbidity, mortality, and HIV transmission, the focal points of HIV Treatment as Prevention campaigns. Interventions to improve the cascade at its various stages may vary substantially in their ability to deliver health value per amount expended. In order to meet global antiretroviral treatment access targets, there is an urgent need to maximize the value of health spending by prioritizing cost-effective interventions. We executed a literature review on economic evaluations of interventions to improve specific stages of the cascade of HIV care. In total, 33 articles met the criteria for inclusion in the review, 22 (67 %) of ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Australia's Seventh National HIV Strategy and the AIDS 2014 Legacy Statement.
Authors: Crooks L, Kidd MR PMID: 25163362 [PubMed - in process] (Source: Med J Aust)
The clinical effectiveness of pegylated interferon and ribavirin for the treatment of chronic hepatitis C in HIV-infected patients in Brazil: a multicentric study.
CONCLUSIONS: in our Brazilian case series, the SVR rate under current clinical practice conditions was similar to that reported in other studies. There was a correlation between an SVR and being infected by genotypes 2 and 3, low viral load, high ALT levels at the onset of treatment, and absence of an AIDS-defining illness. Cytopenia and psychiatric disorders were the major causes of treatment interruption. Efforts should be focused on optimizing management of side effects and counseling to improve adherence and to keep patients on treatment. PMID: 25181403 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)
Medical Services and Associated Costs Vary Widely Among Surgeons Treating Patients With Hand Osteoarthritis.
CONCLUSIONS: Patients who saw additional providers and who were of younger age incurred higher costs and a greater likelihood of undergoing surgery; the latter was also greater in male patients. Use of medical services and associated costs vary widely among providers treating patients with hand OA. Initiatives addressing practice variation-increased use of decision aids, for example-merit additional study. LEVEL OF EVIDENCE: Level III, prognostic study. See the Instructions for Authors for a complete description of levels of evidence. PMID: 25171936 [PubMed - as supplied by publisher] (Source: Clinical Orthopaedics and Related Research)
Highlights from the 2014 International Symposium on HIV & Emerging Infectious Diseases (ISHEID): from cART management to the end of the HIV pandemic.
In this report we not only give details on this main topic but also summarize what has been discussed in the areas of HCV coinfection and present a short summary on currently emerging viral diseases. PMID: 25165483 [PubMed] (Source: AIDS Research and Therapy)
Porn productions suspended after performer tests positive for HIV
LOS ANGELES (Reuters) - A porn industry trade group has placed a moratorium on U.S. productions of adult sex films after one performer received a preliminary positive test for infection by the virus that causes AIDS. (Source: Reuters: Health)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Hiv/aids
The last issue of the Infectious Disease Clinics of North America devoted specifically to HIV/AIDS was published in 1988. Edited by Merle Sande and Paul Volberding, that landmark issue provided a state-of the-art snapshot of the newly defined epidemic, its epidemiology, and the basic principles of treatment and care. Much has happened since then. In 2012, the number of persons living with HIV infection worldwide reached an all-time high of 35.3 million. The medical, social, and economic consequences of this global disaster have reached all continents, presenting society with a health-related challenge unlike any other. (Source: Infectious Diseases Clinics of North America)
Global Epidemiology of HIV
The number of persons living with HIV worldwide reached approximately 35.3 million in 2012. Meanwhile, AIDS-related deaths and new HIV infections have declined. Much of the increase in HIV prevalence is from rapidly increasing numbers of people on antiretroviral treatment who are now living longer. There is regional variation in epidemiologic patterns, major modes of HIV transmission, and HIV program response. It is important to focus on HIV incidence, rather than prevalence, to provide information about HIV transmission patterns and populations at risk. Expanding HIV treatment will function as a preventive measure through decreasing horizontal and vertical transmission of HIV. (Source: Infectious Diseases Clinics of North America)
Forthcoming Issues
Updates in HIV and AIDS: Part II Michael S. Saag and Henry Masur, Editors (Source: Infectious Diseases Clinics of North America)
Porn star tests positive for HIV
An adult film performer tested positive for the AIDS virus, raising concern about adherence to safer sex policies on set (Source: Health News: CBSNews.com)
Malawi: APM Joins African Leaders to Show Commitment to the Fight Against HIV and Aids
[Malawi News Agency]Blantyre -President Professor Arthur Peter Mutharika on Thursday joined other 15 African Heads of State who have signed the 'Protect the Goal Campaign' as a sign of commitment to the fight against HIV and AIDS. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Sudan: Sudan Says Suspected Ebola Patient Died of Aids
[Sudan Tribune]Khartoum -The Darfur Regional Authority (DRA) announced that a "weakly suspected" Ebola virus case was infected with HIV. The patient whose identity was not disclosed came from the Chadian town of Abeche and suffered from viral hemorrhagic fever. (Source: AllAfrica News: Health and Medicine)
Liberia: NOCAL Supports 'Feed the Future'
[New Dawn]The National Oil Company of Liberia or NOCAL has provided several items to a local organization, 'Feed the Future,' as part of the ongoing Ebola fight. Items donated on Wednesday, 28 August include a consignment of Clorox, heavy duty rubber gloves and detergent soap. NOCAL also provided mattresses, buckets, clothing, assorted food items as well as other basic commodities. (Source: AllAfrica News: HIV-Aids and STDs)
Zimbabwe: Prophets Risk Arrest Over HIV Cure Claims
[New Zimbabwe]PROPHETS who claim to be able cure HIV/AIDS and other diseases such as cancer risk arrest for urging sufferers to stop taking their medications, a government minister said Thursday. (Source: AllAfrica News: HIV-Aids and STDs)
Zimbabwe: Wife Starves HIV+ Hubby
[The Herald]An HIV-positive man yesterday told the Harare Civil Court that his abusive wife forced him to sleep naked every night during the just-ended winter season despite telling her that he was feeling cold. (Source: AllAfrica News: HIV-Aids and STDs)
Serological response to 13-valent pneumococcal conjugate vaccine in children and adolescents with perinatally acquired HIV infection
Conclusion:Children with paHIV mount a robust serological response to PCV13 for most but not all vaccine serotypes. Viral load suppression with HAART and higher baseline IgG concentration are associated with higher postvaccination antibody levels. This has implications for HAART treatment and vaccination practices. (Source: AIDS)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Mobile app on emergency cardiac care aids best decisions in seconds
(European Society of Cardiology) The ACCA Clinical Decision-Making Toolkit mobile app is now available on the App Store and Google Play. (Source: EurekAlert! - Medicine and Health)
Zambia: Zambia Earns Kudos On PMTCT Gains
[Times of Zambia]ZAMBIA has been cited by the United Nations Programme on HIV/AIDS (UNAIDS) as one of the top seven best performing countries in the world in Prevention of Mother-to-Child Transmission (PMTCT). (Source: AllAfrica News: HIV-Aids and STDs)
Electrical stimulation 'aids memory'
Electromagnetic stimulation of a specific part of the brain may improve the ability to remember certain facts, researchers say. (Source: BBC News | Health | UK Edition)
FDA Approves New Fixed-Dose Combination Drug, Triumeq (Abacavir Sulfate/Dolutegravir/Lamivudine), to Treat HIV Infection
&quot;On August 22, 2014, FDA approved a new fixed-dose combination product: TRIUMEQ, a combination of dolutegravir (integrase strand transfer inhibitor), abacavir sulfate and lamivudine (both nucleoside analogue reverse transcriptase inhibitors) for the treatment of HIV-1 infection.&nbsp; &quot;TRIUMEQ alone is not recommended for use in patients with current or past history of resistance to any components of TRIUMEQ. &quot;TRIUMEQ alone is not recommended in patients with resistance-associated integrase substitutions or clinically suspected integrase strand transfer inhibitor resistance because the dose of dolutegravir in TRIUMEQ is insufficient in these subpopulations. See full prescribing information for dolutegravir.&nbsp; &quot;The recommended dosage regimen of TRIUMEQ in adult...
FDA Updates Etravirine Labeling
&quot;On August 20, 2014, the Intelence (etravirine) label was updated to include information regarding coadministration of etravirine with the following drugs: &quot;dolutegravir, dolutegravir/darunavir/ritonavir, dolutegravir/lopinavir/ritonavir &quot;atazanavir/ritonavir &quot;boceprevir&quot; The updated labeling for etravirine is available at the FDA website. More information is available: FDA: Press release AIDSinfo: Patient fact sheet on etravirine (Source: AIDSinfo At-a-Glance: Offering Information on HIV/AIDS Treatment, Prevention, and Research, A Service of the U.S. Department of Health and Human Services (DHHS))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
News from CDC and NIAID
From CDC: August 27, 2014: New CDC Campaign Urges Latinos to Speak Up About HIV From NIAID: August 26, 2014: HIV Antibodies Block Infection by Reservoir-Derived Virus in Laboratory Study (Source: AIDSinfo At-a-Glance: Offering Information on HIV/AIDS Treatment, Prevention, and Research, A Service of the U.S. Department of Health and Human Services (DHHS))
Human Papillomavirus Vaccination.
This report summarizes the epidemiology of human papillomavirus (HPV) and associated diseases, describes the licensed HPV vaccines, provides updated data from clinical trials and postlicensure safety studies, and compiles recommendations from CDC's Advisory Committee on Immunization Practices (ACIP) for use of HPV vaccines. Persistent infection with oncogenic HPV types can cause cervical cancer in women as well as other anogenital and oropharyngeal cancers in women and men. HPV also causes genital warts. Two HPV vaccines are licensed in the United States. Both are composed of type-specific HPV L1 protein, the major capsid protein of HPV. Expression of the L1 protein using recombinant DNA technology produces noninfectious virus-like particles (VLPs). Quadrivalent HPV vaccine (HPV4) contains...
The Brazilian version of STarT Back Screening Tool - translation, cross-cultural adaptation and reliability.
Conclusion: The translated and cross-culturally adapted SBST-Brazil proved to be reliable for screening patients according to their risk of poor prognosis and the presence of psychosocial factors. PMID: 25185032 [PubMed - as supplied by publisher] (Source: Physical Therapy)
[Perspective] Rekindled HIV infection
What does the ?Mississippi baby? tell us about curing HIV-1 infection? Authors: Janet D. Siliciano, Robert F. Siliciano (Source: Science: Current Issue)
All-Cause and Cause-Specific Mortality Among U.S. Youth: Socioeconomic and Rural-Urban Disparities and International Patterns
An analysis of the socioeconomic and rural-urban disparities in all-cause mortality and mortality from homicide, suicide, unintentional injuries and HIV/AIDS among American youth. -- (Source: Rural publications via the Rural Assistance Center)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Programmed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load
Conclusion:Collectively, these data suggest that PD-1 expression on HIV-1-specific CD8+ T cells tracks antigen load at the level of epitope specificity and TCR clonotype usage. These findings are important because they provide evidence that PD-1 expression levels are influenced by peptide/HLA class I antigen exposure. (Source: AIDS)
Hypothalamic-Pituitary-Adrenal Axis in HIV Infection and Disease
HIV infection induces hypothalamic-pituitary-adrenal (HPA) axis derangements. Partial glucocorticoid resistance has been observed in a subset of AIDS patients, possibly owing to HIV-induced altered cytokine secretion and action. Because glucocorticoids have immunomodulatory effects, the severity of the HPA axis disorder could play a central role in disease progression. The characteristic phenotype of AIDS patients (visceral obesity, lipodystrophy) may be owing to effects of HIV proteins on the HPA axis, including changes in glucocorticoid and insulin sensitivity of target tissues, as well as altered cytokine production and interaction with the HPA axis, genetic causes, comorbidities, and, possibly, use of antiretroviral agents. (Source: Endocrinology and Metabolism Clinics of North America...
From Wasting to Obesity, Changes in Nutritional Concerns in HIV/AIDS
Optimal nutrition is an important part of human immunodeficiency virus (HIV) care; to support the immune system, limit HIV-associated complications as well as maintain better quality of life and survival. The presentation and nature of malnutrition in patients with HIV has changed dramatically over the past 30 years from predominantly a wasting syndrome to lipodystrophy and, now, frailty. Nevertheless, we continue to see all 3 presentations in patient care today. The pathogenesis of poor nutrition in HIV-infected patients depends on caloric intake, intestinal nutrient absorption/translocation, and resting energy expenditure, which are features seen in all chronic diseases. (Source: Endocrinology and Metabolism Clinics of North America)
Africa: Does the Global HIV Response Understand Sex?
[IRIN]Melbourne -Stigma, squeamishness and misunderstanding of anal sex is leading to research gaps and inaccurate information about the risks of this common sexual behaviour, and hindering effective HIV/AIDS prevention strategies, experts say. A move towards "sex positive" approaches could enhance social acceptance and increase protection. (Source: AllAfrica News: HIV-Aids and STDs)
Warming Aids Arctic Economies But Far Short Of 'Cold Rush'
Climate change is aiding shipping, fisheries and tourism in the Arctic but the economic gains fall short of a &quot;cold rush&quot; for an icy region where temperatures are rising twice as fast as... -- Read more on ScientificAmerican.com (Source: Scientific American - Official RSS Feed)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
California Trees Harbor Fungus Deadly to People with HIV
A 13-year-old's science fair project helped the discovery along, researchers say Source: HealthDay Related MedlinePlus Pages: Fungal Infections, HIV/AIDS and Infections (Source: MedlinePlus Health News)
Ghana: President Mahama Hopeful of HIV and Aids Elimination
[Ghana Govt.]President John Dramani Mahama last Friday said Ghana had the potential to reduce the incidence of HIV and AIDS new infections to zero per cent if proper regulations are adhered to. (Source: AllAfrica News: HIV-Aids and STDs)
Depression therapy aids other cancer symptoms
Conclusion Not surprisingly, this well-conducted study suggests that offering cancer patients with clinical depression an intensive, systematic treatment for depression involving all the people involved in their care, works better than the current approach. As the authors point out, the trial had some limitations. The sample was mainly women receiving follow-up or adjuvant treatment for breast and gynaecological cancers, so it is unclear whether the findings are generalisable to other cancer patients. Also, patients and their GPs could not be ?masked? as to whether they were in the DCPC group or the group receiving usual care, which might have influenced the findings. The striking results for patients in the DCPC group is probably attributable to treatment for depression being intens...
Kenya: Residents Urged to Accept Cut
[The Star]RESIDENTS of North Alego location, Bondo constituency have been urged to take up Voluntary Medical Male Circumcision as a preventive measure to fight HIV-Aids. (Source: AllAfrica News: HIV-Aids and STDs)
Zimbabwe: Woman Sticks By Man Who Infected Her With HIV
[The Herald]A Harare woman yesterday told the court that she would neither consent to advice to divorce nor accept a token of divorce from her husband because he infected her with HIV. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Kenya: HIV Groups in Kenyan Slum Organize Self-Help
[VOA]Nairobi -Kenyans living with HIV or AIDS in Kibera, Nairobi's largest slum, are finding support groups essential to coping with the health, economic and social challenges they face. (Source: AllAfrica News: Health and Medicine)
Uganda: HIV Prevention Act Angers Ugandan Aids Activists
[VOA]Kampala -Uganda's president recently signed the HIV and AIDS Prevention and Control Act into law. The bill criminalizes the transmission of HIV and also enforces mandatory testing. Such provisions have upset activists who want to de-stigmatize Uganda's HIV-positive community. (Source: AllAfrica News: Health and Medicine)
Sensory-tested drug-delivery vehicle could limit spread of HIV, AIDS
(Penn State) A unique method for delivering compounds that could positively impact the global battle against HIV and AIDS may be possible, thanks to researchers in Penn State's College of Agricultural Sciences. (Source: EurekAlert! - Medicine and Health)
New tool aids stem cell engineering for medical research
(Mayo Clinic) A Mayo Clinic researcher and his collaborators have developed an online analytic tool that will speed up and enhance the process of re-engineering cells for biomedical investigation. CellNet is a free-use Internet platform that uses network biology methods to aid stem cell engineering. Details of CellNet and its application to stem cell engineering are described in two back-to-back papers in the journal Cell. (Source: EurekAlert! - Biology)
New Tool Aids Stem Cell Engineering for Medical Research
ROCHESTER, Minn. ? A Mayo Clinic researcher and his collaborators have developed an online analytic tool that will speed up and enhance the process of re-engineering cells for biomedical investigation. CellNet is a free-use Internet platform that uses network biology methods to aid stem cell engineering. Details of CellNet and its application to stem cell [...] (Source: Mayo Clinic Research News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Police interference with methadone treatment in Bangkok, Thailand
Methadone maintenance therapy is an evidence-based pharmacotherapy to treat opioid dependence (World Health Organization [WHO], United Nations Office on Drugs and Crime, & Joint United Nations Programme on HIV/AIDS, 2012). The WHO and other United Nations agencies recommend it as part of essential services for the prevention, treatment and care of human immunodeficiency virus (HIV) infection among people who inject drugs (IDU) as it has been demonstrated to reduce HIV risk behaviour and improve access and adherence to HIV treatment among this population (WHO et al., 2012). (Source: International Journal of Drug Policy)
54th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)54th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
Read clinically focused news coverage of key developments from ICAAC 2014. Medscape Infectious Diseases (Source: Medscape Hiv-Aids Headlines)
Africa: Human Rights Must Be Central to HIV Prevention Efforts
[Key Correspondents]Last month, Australia hosted the 20th International AIDS Conference in Melbourne, putting HIV and human rights high on the agenda in discussions on the new post 2015 development goals. (Source: AllAfrica News: Health and Medicine)
South Africa: U.S.-Sponsored Momconnect APP Provides Free Antenatal Information
[U.S. Embassy Pretoria]The U.S. Government, through the U.S. President's Emergency Plan for AIDS Relief (PEPFAR) program has invested $4.9 million (R49million) towards MomConnect, a program aimed at preventing maternal mortality through the use of mobile phone technology. (Source: AllAfrica News: Pregnancy and Childbirth)
Malawi: Gyan Arrives in the Country On Wednesday for HIV Prevention Campaign
[Malawi News Agency]Lilongwe -Renowned football ace, Asmoah Gyan who is also the team captain for the Ghana national side will arrive in the country today (Wednesday) evening as part of HIV Prevention Protect Goal campaign. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Malawi: President Mutharika to Sign Golden Ball Reaffirming Commitment to Prevent HIV
[Malawi News Agency]Lilongwe -State President Prof. Peter Mutharika will on Thursday sign a Golden Ball committing himself to HIV prevention. (Source: AllAfrica News: HIV-Aids and STDs)
Malawi: CYECE Empower Youths With SRH
[Malawi News Agency]Lilongwe -Promotion of sexual reproductive health, rights and HIV, enhancing youth empowerment and child rights and protection are some of the priority issues that have formed the backbone of the youth strategic plan that has been launched by Centre for Youth Empowerment and Civic Education (CYECE). (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: Ebola Overtakes HIV, Hepatitis As Health Concern
[Daily Trust]In the past month since Ebola landed in Nigeria, it has sped past major health issues to the topmost health concern for Nigerians, a new survey suggests. (Source: AllAfrica News: HIV-Aids and STDs)
Mervyn Susser, 92, Dies; Studied Illness and Society
Dr. Susser and his wife, Dr. Zena Stein, promoted some of the earliest educational and treatment programs for AIDS in South Africa. (Source: NYT Health)
Targeting Chemokine Receptor CXCR4 for Treatment of HIV-1 Infection, Tumor Progression, and Metastasis.
Authors: Choi WT, Yang Y, Xu Y, An J Abstract The chemokine receptor CXCR4 is required for the entry of human immunodeficiency virus type 1 (HIV-1) into target cells and for the development and dissemination of various types of cancers, including gastrointestinal, cutaneous, head and neck, pulmonary, gynecological, genitourinary, neurological, and hematological malignancies. The T-cell (T)-tropic HIV-1 strains use CXCR4 as the entry coreceptor; consequently, multiple CXCR4 antagonistic inhibitors have been developed for the treatment of acquired immune deficiency syndrome (AIDS). However, other potential applications of CXCR4 antagonists have become apparent since its discovery in 1996. In fact, increasing evidence demonstrates that epithelial and hematopoietic tumor cells exploit ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Chemokine Receptor CCR5 Antagonist Maraviroc: Medicinal Chemistry and Clinical Applications.
Authors: Xu GG, Guo J, Wu Y Abstract The human immunodeficiency virus (HIV) causes acquired immumodeficiency syndrome (AIDS), one of the worst global pandemic. The virus infects human CD4 T cells and macrophages, and causes CD4 depletion. HIV enters target cells through the binding of the viral envelope glycoprotein to CD4 and the chemokine coreceptor, CXCR4 or CCR5. In particular, the CCR5-utilizing viruses predominate in the blood during the disease course. CCR5 is expressed on the surface of various immune cells including macrophages, monocytes, microglia, dendric cells, and active memory CD4 T cells. In the human population, the CCR5 genomic mutation, CCR5?32, is associated with relative resistance to HIV. These findings paved the way for the discovery and development of CCR5...
Maintenance of virologic efficacy and decrease in levels of ?2-microglobulin, soluble CD40L and soluble CD14 after switching previously treated HIV-infected patients to an NRTI-sparing dual therapy.
Authors: Romero-Sánchez MC, Alvarez-Ríos AI, Bernal-Morell E, Genebat M, Vera F, Benhnia MR, Bravo-Urbieta J, Galera-Peñaranda C, de Pablo-Bernal RS, Abad-Carrillo MA, Leal M, Ruiz-Mateos E, The VIH-GEMUVIH Región de Murcia Study Group Abstract Novel strategies are necessary to decrease inflammatory parameters in successfully treated HIV-infected patients. Our aim was to evaluate the maintenance of viral suppression and potential changes in inflammatory, immune-activation and coagulation biomarkers in virologically suppressed HIV-infected patients switched to a nucleoside reverse transcriptase inhibitor-sparing (NRTI) and maraviroc (MVC)-containing combined antiretroviral therapy (cART). Fifty-eight HIV-infected patients were observed after their treatment regimens were changed...
AIDS Progress in South Africa Is in Peril
Though few Americans realize it, South Africa owes much of its success in the fight against AIDS to a single United States program ? one that is now moving elsewhere. (Source: NYT)
Malawi: CCC Winds Up Its HIV Prevention Project in Mulanje
[Malawi News Agency]Mulanje -The Christian Community Church has this month wound up its Evidence Based Targeted HIV Prevention Project that was being implemented in Mulanje district. (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: Awiti Teams to Fight Aids in Homa Bay
[The Star]AN inter-departmental committee will be formed in Homa Bay to coordinate HIV-Aids campaigns, Governor Cyprian Awiti has said. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Zambia: USAID Happy With Zambia's HIV/Aids Fight
[Times of Zambia]THE United States Agency for International Development (USAID) is elated with the strides Zambia has scored in the fight against HIV and AIDS. (Source: AllAfrica News: HIV-Aids and STDs)
Uganda: You Need More Than One Laboratory Test, Some Times
[Independent]Laura and Martin wanted to settle down together. They decided to do the necessary medical tests. That is when bad news struck; Laura was told she is HIV positive. (Source: AllAfrica News: HIV-Aids and STDs)
Zimbabwe: Fear-Struck Galz Holds On to HIV Research Data
[New Zimbabwe]THE Gays and Lesbians of Zimbabwe (GALZ) on Monday said they are holding on to research data on HIV prevalence among the gay community because of fear of victimisation by the government. (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: Leaders Told to Spearhead HIV-Aids War
[The Star]ELECTED leaders from Luo Nyanza are to blame for the high HIV-Aids infections in the region, Uriri politician Paul Odhiambo has said. (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: Kenya HIV Prevalence 4th Highest Globally
[New Times]Policy makers in the region are mulling several measures, including voluntary male circumcision, antiretroviral therapy, sustained behaviour change and condom distribution to fight HIV and other STIs. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
In Vivo HIV-1 Hypermutation and Viral Loads Among Antiretroviral-Naive Brazilian Patients
AIDS Research and Human Retroviruses , Vol. 0, No. 0. (Source: AIDS Research and Human Retroviruses)
Adherence to highly active antiretroviral therapy and associated factors among children at the University of Gondar Hospital and Gondar Poly Clinic, Northwest Ethiopia: a cross-sectional institutional based study
Conclusion: Adherence rate to ART was found to be high. Disclosure of the child's HIV sero status to the child, the age of the child and the knowledge of the caregivers towards ART were factors associated with adherence. (Source: BMC Public Health - Latest articles)
Analysis of Special Education Policy in Turkey and United States: Improving Turkey's Policy for Students with Intellectual Disability
Abstract The authors compare the special education law of Turkey with comparable law of the United States. The basis of the comparison is the legal framework represented by the six principles of the special education law of the United States, the Individuals with Disabilities Education Act. Within each principle, the special implications for students with intellectual disability are noted. Suggestions for improving Turkey's special education law are made. These relate principally to the principles of zero reject and issues related to discipline; appropriate education, and issues concerning related services and supplementary aids and services; least restrictive environment as related specifically to students with intellectual disability; procedural due process and issues related to notice f...
Safety status system for operating room devices.
CONCLUSIONS: The safety status system was suitable for an OR complex, both from a usability and technical point of view, and an increase of reported malfunctions was observed. The system eases monitoring the safety status of equipment and is a promising tool to improve the safety related to OR devices. PMID: 25159999 [PubMed - as supplied by publisher] (Source: Technology and Health Care)
Using Syndemic Theory to Understand Vulnerability to HIV Infection among Black and Latino Men in New York City
Abstract HIV is a public health crisis that disproportionately affects Black and Latino men. To understand this crisis, syndemic theory, which takes into account multiple interrelated epidemics, should be used. A syndemic is ?two or more afflictions, interacting synergistically, contributing to excess burden of disease in a population.? Vulnerability to HIV among Black and Latino men is increased as structural, social, and biological factors interact in the context of social marginalization. In New York City, Black and Latino men experience a syndemic of HIV/AIDS, substance abuse, trauma, incarceration, and poverty; however, current research has yet to fully identify the mechanisms of resilience that may reduce the negative impact of a syndemic or explore the potential adaptiv...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
[Media Watch] Public health on film
Few of us who grew up in Britain during the 1980s can have forgotten the famous tombstone public health film about AIDS. The image of a giant tombstone, blasting out of an apocalyptic landscape and chiselled with the word ?AIDS?, remains seared into the collective memory of a generation. First aired in 1987, the film presented AIDS as a deadly disease posing a threat to us all. With its dramatic funereal imagery, coupled with a doom-laden voiceover by the actor John Hurt, the film struck fear into the hearts of many. (Source: The Lancet Infectious Diseases)
[Media Watch] Living with HIV and dying with AIDS
The HIV pandemic has been the biggest threat to human health in recent history. This book examines two facets that lie at the heart of the HIV epidemic: first, the injustices and inequalities in relation to sex, race, sexuality, class, and geography; and second, the adverse social effect of HIV on individuals and their families, communities, and societies. (Source: The Lancet Infectious Diseases)
[Newsdesk] Highlights from the 20th International AIDS Conference
Likely to forevever be associated with the deaths of delegates on flight MH17, AIDS 2014 saw new targets for an end to AIDS and calls to combat discrimination. Peter Hayward reports. (Source: The Lancet Infectious Diseases)
[Comment] AIDS 2014?how the community responded to MH17
The news came through as we turned on our mobile phones, just minutes after the news of the MH17 plane crash broke. The circumstances of the crash were unknown at that time, and worried relatives had tried to contact many on our flight. We landed in Melbourne at 2am on a delayed Malaysian Airlines flight 129 from Kuala Lumpur. The same flight a day later should have carried several natives of the city and six delegates for the International AIDS Society's 2014 meeting who died when MH17 was shot down over eastern Ukraine. (Source: The Lancet Infectious Diseases)
[Corrections] Corrections
Shah SK, Persaud D, Wendler DS, et al. Research into a functional cure for HIV in neonates: the need for ethical foresight. Lancet Infect Dis 2014; 14: 893?98?In this Personal View, the following funding information should have been added to the Acknowledgments section: ?Work on this manuscript by DP and HT was supported in part by the Johns Hopkins Center for AIDS Research, funded by the National Institutes of Health (grant number 1P30AI094189).? These changes have been made to the online version as of Aug 25, 2014. (Source: The Lancet Infectious Diseases)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Protein's ability to inhibit HIV release discovered
A family of proteins that promotes virus entry into cells also has the ability to block the release of HIV and other viruses, researchers have found. It is estimated that more than one million Americans currently are living with AIDS. AIDS is a condition characterized by progressive failure of the immune system. It is caused by the human immunodeficiency virus type 1 (HIV-1). (Source: ScienceDaily Headlines)
Three Approaches to Beating the AIDS Epidemic in South Africa
The pilot programs focus on subgroups like gay men, prostitutes, truckers, prisoners, miners and patients who don?t take their drugs regularly. (Source: NYT Health)
AIDS Progress in South Africa in Peril
Though few Americans realize it, South Africa owes much of its success in the fight against AIDS to a single United States program ? one that is now in moving elsewhere. (Source: NYT Health)
AIDS Progress in South Africa Is in Peril
Though few Americans realize it, South Africa owes much of its success in the fight against AIDS to a single United States program ? one that is now moving elsewhere. (Source: NYT Health)
Hip hip, HARAA!
Click here to watch Team Haraa give us a hip hop low-down on their work: Hip Hip Haraa! 6 weeks in Haraa, it&#8217;s been real great Our team so safi, each other we don&#8217;t even hate We feel so karibu here, it&#8217;s home in our heart Hate to say baadae to our mamas and babas as we depart. We&#8217;ve been teaching in the school, the field, store fronts, to anyone who will listen 5 fluids, 4 doors, and 3 ways of transmission On testing day the people came out and our goals we bested, For the only way to know your status is to get tested People dragged out their friends, the whole event was quite grand, The future of Haraa was in their hand Supporting each other even when results were feared, Tuko Pamoja Kuushinda UKIMWI, together we cheered! We taught a bunch, but learned even more,...
Pre-Exposure Prophylaxis and Contraception EffectivenessPre-Exposure Prophylaxis and Contraception Effectiveness
How effective are hormonal contraceptives for pregnancy prevention in women taking HIV pre-exposure prophylaxis? AIDS (Source: Medscape Today Headlines)
Raltegravir in Virologically Suppressed Overweight WomenRaltegravir in Virologically Suppressed Overweight Women
When women with central adiposity switch to RAL from a PI or NNRTI, they could experience a significant decrease in sCD14. HIV Medicine (Source: Medscape Today Headlines)
Kenya: Circumcision Secretariat Closes
[The Star]The secretariat that coordinated all voluntary medical male circumcision in Kenya the last six years has closed. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Kenya: Govt Weary of Public Response to HIV and Aids Scourge
[The Star]Although HIV and Aids have highly been demystified, the government is warning of dire consequences if the current behavioural trend continue. (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: Join Fight On HIV-Aids, Awiti Tells Leaders
[The Star]HOMA BAY Governor Cyprian Awiti has decried the high rate of HIV-Aids infection in the county. (Source: AllAfrica News: HIV-Aids and STDs)
Zambia: Chief Chikanta Launches Policy to Combat HIV/Aids
[Times of Zambia]CHIEF Chikanta and his subjects in Kalomo District have launched a leadership declaration to commit to combat HIVAIDS in a comprehensive manner. (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: Kenya Launches HIV Prevention Road Map
[Sabahi]The Kenyan government on Wednesday (August 20th) launched a new HIV prevention programme in an effort to achieve "zero new HIV infections in Kenya", United Nations AIDS announced. (Source: AllAfrica News: HIV-Aids and STDs)
Zambia: Chikanta HIV/Aids Policy a Milestone
[Times of Zambia]WITH the cure for HIV/AIDS still elusive, it is clear that the fight against the pandemic cannot be restricted to one group but all the people have a role to play in stopping it. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Tanzania: Mkapa Foundation Hailed for Complementing Govt Efforts
[Daily News]Mwanza -THE government has commended the Benjamin Mkapa HIV-AIDS Foundation for its dedication and support in complementing the country's health initiatives by reaching the underserved members of the society. (Source: AllAfrica News: HIV-Aids and STDs)
Hysteresis in the dynamic perception of scenes and objects.
Scenes and objects are effortlessly processed and integrated by the human visual system. Given the distinct neural and behavioral substrates of scene and object processing, it is likely that individuals sometimes preferentially rely on one process or the other when viewing canonical ?scene? or ?object? stimuli. This would allow the visual system to maximize the specific benefits of these 2 types of processing. It is less obvious which of these modes of perception would be invoked during naturalistic visual transition between a focused view of a single object and an expansive view of an entire scene, particularly at intermediate views that may not be assigned readily to either stimulus category. In the current study, we asked observers to report their online perception of such dynam...
Zimbabwe: Condoms Used to Ease Arthritis Pain
[Zimbabwe Standard]Free condoms distributed in the country to reduce the spread of HIV and Aids have found an unexpected user in Zimbabwe - they are now being use to "treat" arthritis. (Source: AllAfrica News: Health and Medicine)
The development of simple anthropometric measures to diagnose antiretroviral therapy-associated lipodystrophy in resource limited settings.
CONCLUSIONS: We were able to develop simple, anthropometric measures for defining lipoatrophy and lipohypertrophy, using a sample of black HIV-infected South African women with DXA scans. This is of particular relevance in resource limited settings, where health professionals need simple and inexpensive methods of diagnosing patients with lipoatrophy and lipohypertrophy. PMID: 25143778 [PubMed] (Source: AIDS Research and Therapy)
Editorial: Impact of Alcohol on HIV Related Issues in Human Population or Model System.
Authors: Kumar A Abstract Alcohol abuse and AIDS remain two of the leading public health problems, not only in the United States but throughout the world. Approximately amongst 5% of the total US population, abuses alcohol and this statistic has been fairly consistent during recent years. However, the prevalence of alcohol abuse among HIV-positive individuals has been estimated to be between 29 and 60% in the US [1]. Alcohol use has also been implicated as an important risk factor in HIV transmission. In addition, the incidence of HIV infection has been found to be associated with the overall level of alcohol consumption. In a meta-analysis study, drinkers were found to be at a 77% higher risk of HIV-infection than non-drinkers [2]. In another meta-analysis of studies conducted in ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Oncogenic viruses associated with vulva cancer in HIV-1 patients in Botswana
Conclusion: Our study, suggests that in Botswana, vulvar squamous cell carcinoma (VSCC) is associated with oncogenic viruses present in the niche but the contribution and progression may be regulated by HPV and other immunosuppressive infections that include HIV-1. (Source: Epidemiologic Perspectives and Innovations)
Communicating with disabled children when inpatients: barriers and facilitators identified by parents and professionals in a qualitative study
ConclusionsCommunication with disabled children on the ward was perceived as less than optimal. Parents are instrumental in the communication between their children and professionals. Although aware of the importance of communication with disabled children, staff perceived time pressures and lack of priority given to communicating directly with the child as major barriers. (Source: Health Expectations)
Noted Epidemiologist and Former FDA Deputy Director Janet B....
NDA Partners announced today that Janet B. Arrowsmith, MD, a noted expert in epidemiology and internal medicine and former Deputy Director, Office of AIDS and Special Health Concerns, Office of the...(PRWeb August 23, 2014)Read the full story at http://www.prweb.com/releases/2014/08/prweb12112164.htm (Source: PRWeb: Medical Pharmaceuticals)
Zimbabwe: I Want My Foreskin Back!
[The Herald]Debate is raging across African countries, Zimbabwe included on what happens to men's foreskins following circumcision. (Source: AllAfrica News: HIV-Aids and STDs)
Sustained favourable HIV viral load response in South African patients during concomitant HAART and cancer therapy
HIV infection has led to an increase of both AIDS defining and non?AIDS defining cancers. Immunosuppressive cancer therapy had been noted for increased HIV viral load in cancer patients infected with HIV before the advent of highly active antiretroviral therapy (HAART). Assessing the outcome of concomitant HAART and cancer treatment in regions endemic for HIV is thus important. From a cohort of 34 cancer patients infected with HIV, 10 (six underwent radiotherapy and four chemotherapy) had at least three serial samples collected before, during and after treatment. From each sample, HIV viral load, CD4?+? and CD8?+? cell count was investigated. HIV genotypic drug resistance was assessed for six patients with a detectable HIV viral load at baseline. Of the 10 patients; one was HIV p...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Family Economic Strengthening and Parenting Stress Among Caregivers of AIDS-Orphaned Children: Results from a Cluster Randomized Clinical Trial in Uganda.
This study examines the impact of a family economic strengthening intervention on parenting stress among caregivers of AIDS-orphaned children in Uganda. The study uses data from a 4-year (2008-2012) NIMH randomized clinical trial for AIDS-orphaned children known as Suubi-Maka (N=346 dyads). Child-caregiver dyads from 10 comparable primary schools were randomly assigned to either the control group (n=167 dyads) receiving usual care for school-going orphaned children (such as food aid and scholastic materials) or the treatment group (n=179 dyads) receiving a family economic strengthening intervention (focused on a matched savings account), financial planning and management workshops over and above the usual care. Interviews were conducted at baseline, 12 months and 24 months follow-up. This ...
[Comment] The end of AIDS and the NGO Code of Conduct
Country ownership and health-system strengthening are key global health slogans in the current era of HIV/AIDS treatment scale-up. Their meaning, however, is hotly debated. Is country ownership equivalent to government ownership? Which health system should be strengthened?health care delivered by non-governmental organisations (NGOs), the public sector, private for-profit organisations, or some combination of these actors? Although breakthroughs in HIV treatment have provoked rallying cries for an ?AIDS-free generation? and the ?end of AIDS?, these calls clash with the reality of understaffed public health systems across Africa that struggle to manage their current patient load, let alone the millions of additional patients who require treatment under new WHO HIV treatment guidel...
Male-to-male sex among men who inject drugs in Delhi, India: Overlapping HIV risk behaviours
HIV is a major public health challenge in India with concentrated epidemics among high-risk groups (Moses S et al., 2006; UNAIDS, 2013). People who inject drugs (PWID) and men who have sex with men (MSM) represent two groups targeted by HIV prevention interventions. The National AIDS Control Organisation (NACO) estimates that HIV prevalence among PWID and MSM is 7.1% and 4.4% respectively (National AIDS Control Organisation, 2012b). The sharing of injecting equipment and risky sexual practices are relatively common among PWID in India (Armstrong, Humtsoe, & Kermode, 2011; Indian Council of Medical Research 360, 2011; Sarna et al., 2012; Solomon, Mehta, Latimore, Srikrishnan, & Celentano, 2010a,b), and a high prevalence of unprotected anal sex has been documented among MSM groups, in additi...
HIV infection, bone metabolism, and fractures
With the advent of high active antiretroviral therapy there was a significant improvement on HIV subjects survival. Thus, bone changes related to HIV became an important aspect of these individuals. HIV affects bone remodeling causing bone fragility. In addition, antiretroviral therapy may also negatively affect bone metabolism. Several studies describe an increased incidence of fractures in these patients when compared with controls without the disease. The European Society of AIDS (EACS), and other societies, have included guidance on management of osteoporosis in HIV-infected patients emphasizing the identification of patients with low bone mass. Supplementation of calcium and vitamin D and the use of alendronate in these individuals should be recommended on a case base.Com o advento da...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
FDA OKs New Triple-Combination Pill (Triumeq) for HIV FDA OKs New Triple-Combination Pill (Triumeq) for HIV
Triumeq is the first once-daily fixed-dose triple-combination pill to include dolutegravir. Its components were found superior to currently used single-pill therapy in a previous phase 3 trial. FDA Approvals (Source: Medscape Medical News Headlines)
Botswana: Court Orders Free HIV Meds for Foreign Prisoners
[SALC]Gaborone -Today, the Botswana High Court ordered the government to provide anti-retroviral (ARV) treatment to HIV-positive, foreign prisoners at state expense. (Source: AllAfrica News: HIV-Aids and STDs)
Linker Helps Detect Protein Partners
Biochemistry: Cleavable photo-cross-linker aids protein-protein interaction analysis (Source: Chemical and Engineering News)
Kenya: First Lady Alarmed By High HIV Prevalence in Samburu County
[The Star]First Lady Margaret Kenyatta arrives in Maralal for the official handing over of the 3rd Beyond Zero mobile clinic to Samburu County officials. Photo/PSCU (Source: AllAfrica News: HIV-Aids and STDs)
Fungus deadly to AIDS patients found to grow on trees
Researchers have pinpointed the environmental source of fungal infections that have been sickening HIV/AIDS patients in Southern California for decades. It literally grows on trees. The discovery is based on the science project of a 13-year-old girl, who spent the summer gathering soil and tree samples from areas around Los Angeles hardest hit by infections of the fungus named Cryptococcus gattii (CRIP-to-cock-us GAT-ee-eye). (Source: ScienceDaily Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Tanzania: Mkapa Foundation On HIV/Aids Focuses On 15 Districts
[Daily News]THE Benjamin William Mkapa HIV/AIDS Foundation (BMAF) through its Mkapa Fellows Project is targeting to improve HIV/AIDS and Tuberculosis health service delivery to fifteen districts in Rukwa, Shinyanga, Simiyu, Kagera and Zanzibar . (Source: AllAfrica News: HIV-Aids and STDs)
Zimbabwe: Condom Use Up
[The Herald]The use of condoms increased by 22 percent in the past two decades owing largely to behavioural change, says Population Services International. PSI country director Mrs Louisa Norman said the increase in condom use had contributed to the decline in HIV prevalence rate. She was speaking at the launch of the new protector plus condom "New Man" by Health and Child care Minister Dr David Parirenyatwa in Harare on Wednesday. (Source: AllAfrica News: HIV-Aids and STDs)
Uganda: HIV Law - President Museveni Under Fire
[Observer]Even after the presidential assent, health rights civil society organisations want amendments to the contentious provisions in the 2014 HIV Prevention and Control Act. (Source: AllAfrica News: HIV-Aids and STDs)
Brain Magnetic Resonance Imaging Screening Is Not Useful for HIV-1-Infected Patients Without Neurological Symptoms
AIDS Research and Human Retroviruses , Vol. 0, No. 0. (Source: AIDS Research and Human Retroviruses)
[Perspective] Joep Lange (1954?2014)
A leader in developing therapy for AIDS is tragically killed Author: Jaap Goudsmit (Source: Science: Current Issue)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Functional response of the small multidrug resistance protein EmrE to mutations in transmembrane helix 2
Widespread use of antimicrobials has resulted in the emergence of nosocomial pathogens such as methicillin resistant Staphylococcus aureus (MRSA, [1]), an organism that causes more deaths among U.S. hospital patients than HIV/AIDS and tuberculosis combined [2]. Persistence of MRSA strains is linked to multidrug efflux transporters of the small multidrug resistance (SMR) family [3,4]. Indeed, the first SMR identified, Smr/QacC, was isolated from clinical S. aureus resistant to cationic disinfectants and antiseptics (termed biocides) [5]. (Source: FEBS Letters)
A new prognostic score for AIDS-related lymphomas in the Rituximab-era.
We examined the association of HIV-related and other known risk factors with overall survival in both sets independently. We defined a new score (AIDS-related lymphoma International Prognostic Index) by assigning weights to each significant predictor (age-adjusted international prognostic index, extranodal sites, HIV-score [composed of CD4 count, viral load, and prior history of AIDS]) with three risk categories similar to the age-adjusted International Prognostic Index (low, intermediate and high risk). We compared the prognostic value for overall survival between AIDS-related lymphoma International Prognostic Index and age-adjusted International Prognostic Index in the validation set and found that the AIDS-related lymphoma International Prognostic Index performed significantly better in...
Expression of the Mannose Receptor CD206 in HIV and SIV Encephalitis: A Phenotypic Switch of Brain Perivascular Macrophages with Virus Infection
We examined the expression of the mannose receptor CD206 by perivascular macrophages (PVM) in normal human and monkey brains and in brains of HIV-infected humans and of monkeys infected with simian immunodeficiency virus (SIV). Depletion of brain PVM in SIV-infected monkeys by intrathecal injection of liposome-encapsulated bisphosphonates eliminated CD206-expressing cells in the brain, confirming their perivascular location and phagocytic capacity. In vivo labeling with bromodeoxyuridine in normal uninfected and SIV-infected macaques in combination with CD206 immunostaining revealed a CD206+-to-CD206? shift within pre-existing PVM during SIV brain infection and neuroinflammation. These findings identify CD206 as a unique marker of human and macaque PVM, and underscore the utility of this...
Advances in HIV Prevention for Serodiscordant Couples
Abstract Serodiscordant couples play an important role in maintaining the global HIV epidemic. This review summarizes biobehavioral and biomedical HIV prevention options for serodiscordant couples focusing on advances in 2013 and 2014, including World Health Organization guidelines and best evidence for couples counseling, couple-based interventions, and the use of antiviral agents for prevention. In the past few years, marked advances have been made in HIV prevention for serodiscordant couples and numerous ongoing studies are continuously expanding HIV prevention tools, especially in the area of pre-exposure prophylaxis. Uptake and adherence to antiviral therapy remains a key challenge. Additional research is needed to develop evidence-based interventions for couples, and especia...
Functional response of the small multidrug resistance protein EmrE to mutations in transmembrane helix 2
Widespread use of antimicrobials has resulted in the emergence of nosocomial pathogens such as methicillin resistant Staphylococcus aureus (MRSA, [1]), an organism that causes more deaths among U.S. hospital patients than HIV/AIDS and tuberculosis combined [2]. Persistence of MRSA strains is linked to multidrug efflux transporters of the small multidrug resistance (SMR) family [3,4]. Indeed, the first SMR identified, Smr/QacC, was isolated from clinical S. aureus resistant to cationic disinfectants and antiseptics (termed biocides) [5]. (Source: FEBS Letters)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Vault nanoparticles engineered at UCLA show promise for cancer treatment and possible HIV cure
American Chemical Society UCLA scientists developed a method for placing bryostatin 1 in nanoscale vaults for safe delivery to cells, where it can activate latent HIV, enabling the virus to be eradicated. A multidisciplinary team of scientists from UCLA and Stanford University has used a naturally occurring nanoparticle called a vault to create a novel drug delivery system that could lead to advances in the treatment of cancer and HIV. The research team was led by Dr. Leonard Rome, associate director of UCLA?s California NanoSystems Institute, and Dr. Jerome Zack, co-director of the UCLA AIDS Institute, both of whom are also members of UCLA?s Jonsson Comprehensive Cancer Center. Co-first authors on the study were Daniel Buehler, a UCLA postdoctoral researcher and Matthew Marsden, adju...
HIV/HBV CoinfectionHIV/HBV Coinfection
This guideline from the New York State Department of Health offers guidance to clinicians for vaccination, treatment, and monitoring of hepatitis B infections in HIV-infected patients. Medscape HIV/AIDS (Source: Medscape Hiv-Aids Headlines)
South Africa: Presentations - South Africa's HIV, TB Investment Case
[Health-e]Experts' presentations on South Africa's HIV "investment case" made at a July consultation organised by the country's national AIDS council. (Source: AllAfrica News: HIV-Aids and STDs)
Uganda: Controversial HIV Bill Signed Into Law
[IPS]Kampala -HIV/AIDS activists are adamant Uganda will not achieve an "AIDS-free generation" now a "backwards" HIV/AIDS Bill criminalising the "wilful and intentional" transmission of the disease has been signed into law. (Source: AllAfrica News: Health and Medicine)
Nigeria: Ondo Intensifies Fight Against HIV/Aids
[Daily Independent]Ondo State Agency for the Control of AIDS (ODSACA) has commenced training on Minimum Prevention Intervention Packages and District Head Information System (MPIP/DHIS) for Civil Society Organisations, Executive Directors, Line Ministries Focal persons, Monitoring and Evaluation Officers of State Action Committee on AIDS and Service Support Organisations. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Zambia: PMTCT Real Life Story
[Times of Zambia]THE pain of living through the loss of three children, was enough to discourage Constance Mudenda from ever contemplating parenting! (Source: AllAfrica News: HIV-Aids and STDs)
Fungus deadly to AIDS patients found to grow on trees
(Duke University) Researchers have pinpointed the environmental source of fungal infections that have been sickening HIV/AIDS patients in Southern California for decades. It literally grows on trees. (Source: EurekAlert! - Medicine and Health)
Phylogenetic and Temporal Dynamics of Human Immunodeficiency Virus Type 1B in China: Four Types of B Strains Circulate in China
AIDS Research and Human Retroviruses , Vol. 0, No. 0. (Source: AIDS Research and Human Retroviruses)
Shunt malfunction presenting with symptomatic syringomyelia: Demonstrated on contrast ventriculogram
We report a case of chronic tuberculous meningitis with shunt malfunction presenting as an expanding spinal canal syrinx and quadriparesis. Fourth ventricular communication with syrinx was demonstrated with the help of a contrast ventriculogram. After shunt revision, syrinx resolved completely and the patient made significant improvement in his neurological deficits. The present case illustrates that a historical and rarely used investigation like contrast ventriculogram aids in the diagnosis and management even in the current neurosurgical practice. All patients with late onset syrinx and a previous VP shunt need to be investigated for shunt malfunction before considering syrinx surgery. A simple shunt revision resolves the syrinx in such conditions and avoids more complex procedures like...
Highlights from the 2014 International Symposium on HIV & Emerging Infectious Diseases (ISHEID): from cART management to the end of the HIV pandemic
In this report we not only give details on this main topic but also summarize what has been discussed in the areas of HCV coinfection and present a short summary on currently emerging viral diseases. (Source: AIDS Research and Therapy)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Unusual Presentation of Visceral Leishmaniasis in an HIV-Infected Patient
AIDS Research and Human Retroviruses , Vol. 0, No. 0. (Source: AIDS Research and Human Retroviruses)
Malawi: Kapito Condemns ARV Misuse
[Malawi News Agency]Blantyre -Renowned human rights activist and Consumer Association of Malawi (CAMA) Executive Director, John Kapito has described the misuse of antiretroviral drugs (ARVs) recently reported in the media as disappointing. (Source: AllAfrica News: HIV-Aids and STDs)
Zimbabwe: Zimbabwean Government Takes Action Against Increasing Rape
[Key Correspondents]Every year, more than 3,000 young girls are raped in Zimbabwe - often by members of their own families. With the number of cases increasing, Zimbabwe's government has launched a national campaign to tackle the issue, which is causing great trauma and new HIV infections. (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: Cultural Practices Blamed for HIV-Aids Spread
[The Star]OUTDATED cxultural practices are to blame for the spread of HIV-Aids among the Luo community, an NGO has said. (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: In Rural Kenya, Pressure Builds Against Female Circumcision
[VOA]It's the last day of school in Tharaka-Nithi, a community in Kenya's remote former Eastern province. Classrooms are empty, signaling the start of a one-month break for students. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
[Pneumocystis pneumonia in HIV-infected patients with cytomegalovirus co-infection. Two case reports and a literature review].
Authors: Polaczek MM, Zych J, Oniszh K, Szopi?ski J, Grudny J, Roszkowski-?li? K Abstract Pneumocystis pneumonia (PCP) is one of the infectious lung diseases diagnosed in HIV-infected patients. The pathogen responsible for the development of this opportunistic infection is an atypical fungus called Pneumocystis jiroveci. PCP remains the most common disorder diagnosed at the onset of acquired immunodeficiency syndrome (AIDS), especially in individuals not aware of their HIV infection. The most important risk factor of PCP development in HIV-infected person is the decrease of T CD4+ cell number below 200/mcL. Clinical symptoms consist of: chronic cough, dyspnoea and weakness. Arterial blood gas analysis often reveals the presence of hypoxaemia, and high-resolution computed tomogra...
Uganda: Uganda On Track With Paediatric HIV Control
[Observer]Once, while visiting Baylor College of Medicine in Mulago, I was welcomed by a group of 15 children, happily swaying to the melody of their song. (Source: AllAfrica News: HIV-Aids and STDs)
Zimbabwe: 'Mining Communities At Risk of Contracting TB'
[The Herald]People working and living in mining communities could be six times more at risk of contracting tuberculosis than those in other occupations, Government has said. Deputy director of Aids and Tuberculosis in the Ministry of Health and Child Care, Dr Charles Sandy, said the statistics were based on trends coming from other countries such as South Africa, Botswana and those of Zimbabwe. (Source: AllAfrica News: Tuberculosis)
The agnoprotein of polyomavirus JC is released by infected cells: Evidence for Its cellular uptake by uninfected neighboring cells.
Authors: Otlu O, De Simone FI, Otalora YL, Khalili K, Sariyer IK Abstract Poliomavirus JC replicates in glial cells in the brain, and causes the fatal demyelinating disease, progressive multifocal leukoencephalopathy (PML). PML is usually seen in patients with underlying immunocompromised conditions, notably among AIDS patients and those on chronic immunosuppressive regimens. The late leader sequence of JC virus contains an open reading frame encoding a small regulatory protein called agnoprotein. Agnoprotein contributes to progressive viral infection by playing significant roles in viral replication cycle. Here, we demonstrate that agnoprotein can be detected in cell-free fractions of glial cultures infected with JCV, transfected with expression plasmids or transduced with an aden...
Utility of nine-color, 11-parameter flow cytometry for detection of plasma cell neoplasms: a comparison with bone marrow morphologic findings and concurrent m-protein studies in serum and urine.
CONCLUSIONS: The nine-color analytic cocktail eliminates duplication of PC gating reagents required for evaluation of the same epitopes using a five- or six-color approach. Fewer analytic cocktails result in lower instrument acquisition times per case, a significant factor for the large data sets required for optimal residual disease assessment. Finally, concurrent analysis of nine epitopes and two light scatter parameters aids detection of residual disease, particularly when it is mixed with polyclonal PCs. PMID: 25125632 [PubMed - in process] (Source: American Journal of Clinical Pathology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
New vaccine shows promise as stronger weapon against both tuberculosis and leprosy
In many parts of the world, leprosy and tuberculosis live side-by-side. Worldwide there are approximately 233,000 new cases of leprosy per year, with nearly all of them occurring where tuberculosis is endemic. The currently available century-old vaccine Bacille Calmette-Guerin, or BCG, provides only partial protection against both tuberculosis and leprosy, so a more potent vaccine is needed to combat both diseases. UCLA-led research may have found a stronger weapon against both diseases. In a study published in the September issue of the peer-reviewed journal Infection and Immunity, the researchers found that rBCG30, a recombinant variant of BCG that overexpresses a highly abundant 30 kDa protein of the tuberculosis bacterium known as Antigen 85B, is superior to BCG in protecting against t...
HIV and Hepatitis C Risk in Pregnancy and Newborns
Infection with HIV or Hepatitis C is especially prevalent in pregnant women with a history of drug and alcohol use. Although newborn infection rates are becoming less common, this remains an issue of vital importance for prospective adoptive parents.read more (Source: Psychology Today Parenting Center)
Hello again from Nduruma!
Hello again from VP3! It?s been a while since we last checked in, and we?ve been up to a lot here in Nduruma. We?ve added a steady stream of community teachings to the schedule, and are now familiar faces at all of the schools in the ward. We?ve kicked off our district-wide soccer tournament with a hard fought game between the mzungus and the Mzimuni team, and we are also busy planning community day and a few more testing days. Soon we will add getting nostalgic about our time here in Nduruma to our list of activities. Upon some reflection fueled by chipsi mayai, we?ve come to realize we?ve all grown in different ways during our time in village. This blog will attempt to highlight this growth, starting with Ben. Besides the very literal growth of Ben?s luxurious hair, groomed...
Namibia: More and More Men Accept Being Circumcised
[New Era]Katima Mulilo -New statistics from the World Health Organisation (WHO) indicated an estimated 5.8 million males in 14 African priority countries have undergone circumcision over the past five years. (Source: AllAfrica News: HIV-Aids and STDs)
South Africa: Red Cross Dispel Sex Workers Myths in HIV Education
[IFRC]When MG first arrived in the dusty transit town of Musina, northern South Africa - fleeing from the fighting Zimbabwe in 2008 - as an undocumented worker, she started off doing odd jobs. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Africa: People Who Use Drugs Left Behind By Global Funding Gap
[Key Correspondents]The fight to defeat HIV among those most at risk of infection may not be achieved as soon as hoped unless harm reduction services for people who use drugs receive appropriate funding. (Source: AllAfrica News: HIV-Aids and STDs)
Uganda: Helping HIV Positive Women Avoid Unplanned Pregnancies
[IPS]Barbara Kemigisa used to call herself an "HIV/AIDS campaigner". These days she would rather be known as an "HIV/AIDS family planning campaigner". (Source: AllAfrica News: HIV-Aids and STDs)
South Africa: Love, Suspicion and HIV Discordancy
[Health-e]Sindi Letlala* and her 3-year-old son Thato are HIV positive. Sindi's husband of 12 years and Thato's father, Thabiso, is not. She talks to OurHealth about dealing with discordancy. (Source: AllAfrica News: HIV-Aids and STDs)
Therapeutic drug monitoring of voriconazole: a case report of multiple drug interactions in a patient with an increased CYP2C19 activity.
CONCLUSION: The integration of drug-drug interactions and pharmacogenetics data is crucial to interpret drug concentrations correctly, thus preventing suboptimal exposure to voriconazole. PMID: 25120580 [PubMed] (Source: AIDS Research and Therapy)
Influence of providers and nurses on completion of non-targeted HIV screening in an urgent care setting.
CONCLUSIONS: Visit provider and triage nurse were strongly associated with acceptance of testing, which may reflect variable opinions of HIV screening in this setting by clinical staff. Among patients accepting screening, visit provider remained strongly associated with completion of testing. Despite longstanding recommendations for non-targeted HIV screening, further changes to improve the testing and results process, as well as provider education and buy-in, are needed to improve screening rates. PMID: 25120579 [PubMed] (Source: AIDS Research and Therapy)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Differential glycosylation of envelope gp120 is associated with differential recognition of HIV-1 by virus-specific antibodies and cell infection.
CONCLUSION: Our data support the hypothesis that the glycosylation machinery of different cells shapes gp120 glycosylation and, consequently, impacts envelope recognition by specific antibodies as well as the interaction of HIV-1 gp120 with cellular receptors. These findings underscore the importance of selection of appropriately glycosylated HIV-1 envelope as a vaccine antigen. PMID: 25120578 [PubMed] (Source: AIDS Research and Therapy)
Results from a Secondary Data Analysis Regarding Satisfaction with Health Care among African American Women Living with HIV/AIDS
ConclusionBecause satisfaction with health care can influence the quality of care received, health outcomes, and adherence to provider recommendations among patients living with HIV/AIDS, health care providers? ability to elicit satisfaction from their patients is just as important as the services they provide. This project is one of the first studies to find high rates of satisfaction with health care among African American women living with HIV/AIDS. Further examination of satisfaction with health care among African American women living HIV/AIDS may help in narrowing health care disparities and negative treatment outcomes. (Source: Journal of Obstetric, Gynecologic, and Neonatal Nursing)
A Multilevel Understanding of HIV/AIDS Disease Burden Among African American Women
ABSTRACT Disproportionate HIV/AIDS rates among African American women have been examined extensively, primarily from an individual?centered focus. Beyond individual behaviors, factors such as the hyperincarceration of African American men and geographically concentrated disadvantage may better explain inequitable disease burden. In this article I propose a conceptual model of individual, social, and structural factors that influence HIV transmission among African American women. The model can be used to develop comprehensive assessments and guide prevention programs in African American communities. (Source: Journal of Obstetric, Gynecologic, and Neonatal Nursing)
Evidence-based risk communication: a systematic review.
CONCLUSION: Visual aids and absolute risk formats can improve patients' understanding of probabilistic information, whereas numbers needed to treat can lessen their understanding. Due to study heterogeneity, the superiority of any single method for conveying probabilistic information is not established, but there are several good options to help clinicians communicate with patients. PRIMARY FUNDING SOURCE: None. PMID: 25133362 [PubMed - in process] (Source: Annals of Internal Medicine)
Sexually Transmitted Infection Related Stigma and Shame Among African American Male Youth: Implications for Testing Practices, Partner Notification, and Treatment
AIDS Patient Care and STDs Sep 2014, Vol. 28, No. 9: 499-506. (Source: AIDS Patient Care and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Nonoccupational Postexposure Prophylaxis for HIV PreventionNonoccupational Postexposure Prophylaxis for HIV Prevention
There have been many challenges with the implementation of HIV nonoccupational postexposure prophylaxis. What new solutions are on the horizon? AIDS (Source: Medscape Today Headlines)
Helping Uganda?s HIV positive Women Avoid Unplanned Pregnancies
Contraception is a smart choice but HIV positive women have to jump through the hooks to get it. Credit: Amy Fallon/IPSBy Amy FallonKAMPALA, Aug 18 2014 (IPS) Barbara Kemigisa used to call herself an ?HIV/AIDS campaigner?. These days she would rather be known as an ?HIV/AIDS family planning campaigner?. ?We need to reduce unplanned pregnancies and the HIV infection rate in our country,? Kemigisa told IPS during Uganda?s first national family planning conference on July 28. ?It?s about dual protection.? Raped by two uncles from an early age, Kemigisa later became promiscuous. When she was 22, she discovered she was HIV positive &#8211; and two months pregnant. Her daughter, Kourtney, now five, was born negative. But the mother couldn?t afford to buy her formula milk a...
Rwanda: HIV, TB, Malaria Deaths Decline
[New Times]The world's most infectious diseases-HIV/AIDS, tuberculosis and malaria-are losing ground as a result of growing efforts to mobilise resources to combat them. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: Pathetic - How a Movie Star Contracted HIV in the Church
[Vanguard]Her story runs like a novel, yet it is no fiction. It underscores the saying 'misfortunes bring out the best in a person." (Source: AllAfrica News: HIV-Aids and STDs)
Africa: Global Fund Offering Technical Assistance On Community, Rights and Gender
[GFO]Communities and civil society can now receive support from the Global Fund for activities addressing community, rights and gender challenges (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Sudan: Sudan Submits Consolidated Concept Note
[GFO]All three disease components plus health system strengthening included in single pitch (Source: AllAfrica News: HIV-Aids and STDs)
Africa: Pushing the Envelope - Will the Global Fund's New Funding Model Foster Country Ambitions?
[GFO]The new funding model (NFM) is the crucial opportunity to determine the speed with which countries are able to expand and innovate in their responses to the three diseases and to make up for delays in the scale-up of programs that has been stalled since the cancellation of Round 11. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: Workshop Participants Urge the Global Fund to Review Its Policies On Human Rights
[GFO]Concept notes should address structural barriers (Source: AllAfrica News: HIV-Aids and STDs)
Africa: The Weakest Link of HIV Prevention in Africa - Contraception
[IPS]Nairobi -In the rush to save babies from HIV infection and treat their mothers, experts warn that a key element of HIV prevention is being neglected in Africa - contraceptives for HIV positive women. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: She Infected Me With HIV, Dated Other Men - Suspected Wife Killer
[Daily Independent]Lagos -A suspect, Katongu Philip, is currently cooling his heels at the cells of the Criminal Investigations Department (CID) of the Lagos State Police Command, Yaba, over the murder of a lady, Justina James, said to be his wife. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Zambia: Remembering Dr Khama the K-Punch HIV/Aids Drug Pioneer
[Times of Zambia]Would you believe it - you are sick and decide to go and see your doctor at the local surgery only to be told the surgery is no longer functioning because the doctor died several months ago? (Source: AllAfrica News: HIV-Aids and STDs)
Angola: Asa Branca Market With Mobile Clinic for HIV/Aids Blood Test
[ANGOP]Luanda -A mobile clinic for voluntary HIV/Aids blood test and the holding of a family planning is available since Thursday in Asa-Branca market in Cazenga municipality in Luanda in order to deal with vendors and other citizens. (Source: AllAfrica News: HIV-Aids and STDs)
Ethiopia: 'Triple Jeopardy' - the Struggle of the Little Ones
[Reporter]Scattered around the infamous currency black market area (the self-proclaimed forex bureaus) of Addis Ababa - areas including Ambassador Theater and Ethiopia Hotel - young men importune passersby, especially those who, they suspect had come from abroad. (Source: AllAfrica News: HIV-Aids and STDs)
Ethiopia: Helping Men Take Responsibility for Ending Aids
[Reporter]Transformative change is afoot among men and boys throughout southern and eastern Africa. Millions have bravely stepped up to protect themselves and their partners from HIV. (Source: AllAfrica News: Health and Medicine)
AIDS, loss and renewal.
Authors: Kirby TH PMID: 25164845 [PubMed - in process] (Source: Med J Aust)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Emergent trends of perceived needs and concerns in long-term survivors of head and neck cancer using the patients concerns inventory
This study explored associations between PCI outcomes with UWQOL scores. (Source: The British Journal of Oral and Maxillofacial Surgery)
Prevalence of Voluntary Counseling and Testing Utilization and Its Associated Factors among Bahirdar University Students.
Conclusion. The major factors identified for increased VCT service utilization were having a friend who got VCT, having discussion about HIV/AIDS with family, origin of residence, year of study, and having boy- or girlfriend. Therefore, actions targeting these predictors are necessary to effectively enhance the use of the VCT services utilization among students. PMID: 25105028 [PubMed] (Source: Adv Data)
AIDS 2014: Intermittent and 'On-Demand' PrEPAIDS 2014: Intermittent and 'On-Demand' PrEP
Dr. Paul Sax looks at 2 studies from AIDS 2014: the open-label extension of the iPrEx study, and the IPERGAY trial. Medscape HIV/AIDS (Source: Medscape Hiv-Aids Headlines)
West Africa: 5 Things to Do Right Now about Ebola
[AIDS Free World]It's very difficult to know what to say about the Ebola outbreak. Let me take a crack at it: (Source: AllAfrica News: Health and Medicine)
Developing self-sustainable hearing centers in the developing world - case study of EARs Inc project in Dominican Republic.
CONCLUSIONS: The development of comprehensive diagnostic and rehabilitation services requires equipping and training local staff. Implications for Rehabilitation A good hearing aid fitting is more than technology - patient education and the clinician fitting the hearing aid are important. Access to follow-up services including battery supplies, hearing aid adjustments and hearing aid repairs is essential to any hearing aid fitting program in low and middle income countries. Check the WHO guidelines for hearing aid provision in developing countries when planning a program. When working in a country co-ordinate with local professional involved in hearing health where available. PMID: 25119293 [PubMed - in process] (Source: Disability and Rehabilitation. Assistive Technology.)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Namibia: Govt to Introduce Single Dose HIV Drug
[New Era]Oshakati -The Ministry of Health and Social Services is on the verge of phasing out multiple tablet anti-retroviral (ARV) dosage to a single tablet dose per day. (Source: AllAfrica News: HIV-Aids and STDs)
Liberia: 'No Time for Politics' - Says Christopher Neyor As He Aids Anti-Ebola Efforts
[New Republic]The Chief Executive officer (CEO) of MOWEH Energy, Mr. Christopher Neyor, has said the troubling consequences of the Ebola virus have presented the need for all Liberians to stand together, regardless of politics or where one comes from, in combating getting rid of it. (Source: AllAfrica News: Health and Medicine)
Kenya: Residents Told to Go for HIV Tests
[The Star]Bungoma Governor Kenneth Lusaka's wife, Margaret Makelo, has asked county residents to go for HIV tests. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: What's More Important, the War On Aids or Just War?
[IPS]Johannesburg/New York -They say there is a war on and its target is the deadly human immunodeficiency virus (HIV). This war runs worldwide but its main battleground is sub-Saharan Africa, where seven out of 10 HIV positive persons in the world live - 24.7 million in 2013. The region suffered up to 1.3 million AIDS-related deaths in the same year, according to the United Nations. (Source: AllAfrica News: HIV-Aids and STDs)
Rwanda: Editor's Note
[New Times]Dear readers (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Rwanda: Helping Men Take Responsibility to End HIV/Aids
[New Times]Transformative change is afoot among men and boys throughout eastern and southern Africa. Millions have bravely stepped up to protect themselves and their partners from HIV. (Source: AllAfrica News: HIV-Aids and STDs)
Malawi: People Living With HIV Petition Ntcheu District Commissioner
[Malawi News Agency]Ntcheu -Following a two day workshop for people living with HIV and AIDS which was organized by Malawi Interfaith Aids Association in corroboration with Ntcheu District Interfaith Aids Committee, participants to the workshop Tuesday presented a petition which contained some of the challenges which people living with HIV face to Ntcheu District Commissioner. (Source: AllAfrica News: HIV-Aids and STDs)
Sequence-Conserved and Antibody-Accessible Sites in the V1V2 Domain of HIV-1 gp120 Envelope Protein
AIDS Research and Human Retroviruses , Vol. 0, No. 0. (Source: AIDS Research and Human Retroviruses)
Evaluation of treatment outcomes for patients on first?line regimens in US President's Emergency Plan for AIDS Relief (PEPFAR) clinics in Uganda: predictors of virological and immunological response from RV288 analyses
ConclusionsHigh virological suppression rates are achievable on first?line ART in Uganda. The odds of virological suppression were positively associated with efavirenz use and improvements in CD4 cell percentage and total lymphocyte count and negatively associated with the cost of travel to the clinic. CD4 cell reconstitution was positively associated with CD4 count at study visit, time on ART, satisfaction with care at clinic, haemoglobin concentration and total lymphocyte count and negatively associated with age. (Source: HIV Medicine)
The exon junction complex is required for definition and excision of neighboring introns in Drosophila [Research Papers]
Splicing of pre-mRNAs results in the deposition of the exon junction complex (EJC) upstream of exon&ndash;exon boundaries. The EJC plays crucial post-splicing roles in export, translation, localization, and nonsense-mediated decay of mRNAs. It also aids faithful splicing of pre-mRNAs containing large introns, albeit via an unknown mechanism. Here, we show that the core EJC plus the accessory factors RnpS1 and Acinus aid in definition and efficient splicing of neighboring introns. This requires prior deposition of the EJC in close proximity to either an upstream or downstream splicing event. If present in isolation, EJC-dependent introns are splicing-defective also in wild-type cells. Interestingly, the most affected intron belongs to the piwi locus, which explains the reported transposon d...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
AIDSinfo Glossary App Updated for iOS 7
The free AIDSinfo HIV/AIDS Glossary apps for Apple and Android devices provide on-the-go access to definitions for more than 700 HIV/AIDS-related terms in English and Spanish. The apps also include an audio feature so users can hear the correct pronunciation of each term. &nbsp; The Glossary app for iPhone, iPad, and iPod touch is now optimized for iOS7. The updated app features an iOS7-compatible look and feel and a new icon. The upgrade also included minor bug fixes. &nbsp; Whether you are new to the Glossary app or a long-time user, download the latest, iOS7-optimized version of the app for your Apple device today. Feedback on the updated app is welcome. Please e-mail your comments to ContactUs@aidsinfo.nih.gov. &nbsp; (Source: AIDSinfo At-a-Glance: Offering Information on HIV/AIDS Trea...
NIH-Led Scientists Boost Potential of Passive Immunization Against HIV
&quot;Scientists are pursuing injections or intravenous infusions of broadly neutralizing HIV antibodies (bNAbs) as a strategy for preventing HIV infection. This technique, called passive immunization, has been shown to protect monkeys from a monkey form of HIV called simian human immunodeficiency virus, or SHIV. To make passive immunization a widely feasible HIV prevention option for people, scientists want to modify bNAbs such that a modest amount of them is needed only once every few months. &quot;To that end, an NIH-led team of scientists has mutated the powerful anti-HIV bNAb called VRC01 so that, once infused into monkeys, it lasts three times longer in blood than unmutated VRC01, collects in rectal mucosal tissue, and persists there more than twice as long as unmutated VRC01. Conce...
Barriers to sight impairment certification in the UK: the example of a population with diabetes in East London
Conclusions: Our data shows that sight certification in patients with diabetes might be underestimated and these patients often have non-diabetes related visual loss. We propose that data on certifiable visual impairment could serve, along with existing certification databases, as a resource for quality of care standards assessment and service provision for patients with diabetes. (Source: BMC Ophthalmology - Latest articles)
Department of AIDS Control to be merged with Health Ministry; decision riles activists
The merger was first proposed in the 12th Five-Year Plan. Planning Commission suggested that the DAC should be integrated with the National Health Mission . (Source: The Economic Times)
Researchers Should Use More Data, Not Just the HIV Sequence Compendium, for Epidemiology and Other HIV Research
AIDS Research and Human Retroviruses , Vol. 0, No. 0. (Source: AIDS Research and Human Retroviruses)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Molecular Epidemiology, Phylogeny, and Phylodynamics of CRF63_02A1, a Recently Originated HIV-1 Circulating Recombinant Form Spreading in Siberia
AIDS Research and Human Retroviruses , Vol. 0, No. 0. (Source: AIDS Research and Human Retroviruses)
Antibodies, together with viral ?inducers,? found to control HIV in mice
A new strategy devised by researchers at Rockefeller University harnesses the power of broadly neutralizing antibodies, along with a combination of compounds that induce viral transcription, in order to attack latent reservoirs of HIV-infected cells in an approach termed 'shock and kill.' More &#187; (Source: The Rockefeller University Newswire)
Health Literacy and Cultural Competency of FDA Consumer Materials
Healthcare decisions made by members of the public and health care practitioners, including when seeking information to guide decisions regarding medical treatments for conditions such as HIV/AIDS and Hepatitis C, are likely to benefit from epidemiologic evidence. However, the level of information available to the public may not match their health literacy and other needs. Health literacy is the ability to obtain/process/understand health information in order to make healthy decisions. In addition health literacy is considered a social determinant of health, with low health literacy associated with medication errors, low rates of treatment compliance, and higher mortality. (Source: Annals of Epidemiology)
One Woman?s Struggle to Find the Right Contraceptive
Because men wield power in decisions around pregnancy, family planning services should include them. Couple-centred family planning services are sorely needed in Africa. Credit: Mercedes Sayagues/IPSBy Miriam GathigahNAIROBI, Aug 14 2014 (IPS) Beatrice Njeri had just come home from her job as a janitor at a primary school in Nairobi. It was August 2009. Arriving home earlier than usual, the married mother of two found her husband waiting for her in their shanty at Kisumu Ndogo, in the sprawling Kibera slums. He had just discovered he was HIV positive. A week later, she too tested positive. Both were 29 years old at the time. ?We were very young and knew very little about HIV,? she says. Having had two daughters, both HIV negative, they desired a son, but decided not to have another bab...
South Africa: TAC Pickets Michael Mapongwana Baby Unit
[GroundUp]"There is no privacy, you are asked in front of everyone what your baby's HIV status is. It is dirty and the staff is very disrespectful in the way they speak to patients. I don't go to that clinic anymore; it's been a year now. Because of their treatment I did something I shouldn't have done, I tested my child for HIV myself, because I too work at a clinic." (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Compare mDCs and pDCs between two distinct patients groups in acute HIV-1 infection.
In this study, we enrolled two different groups of subjects with acute HIV-1 infection. One group progressed to CD4 counts below 200 cells/?l within 2 years of HIV-1 infection (CD4 Low Group), while the other group maintained CD4 counts above 500 cells/?l (CD4 High Group). We did not find statistical difference in the pDC number between the two groups during acute HIV-1 infection. However, the mDC number was significantly lower in the CD4 Low Group than in the CD4 High Group. PMID: 25104967 [PubMed] (Source: AIDS Research and Therapy)
HCV RNA viral load is independent from CD4 cell count and plasma HIV RNA viral load in immunocompetent HIV-HCV co-infected patients: a 3-years follow-up study.
CONCLUSIONS: The HCV RNA load, a known pretreatment predictor of response to antiviral therapy, was independent of the two main parameters of HIV disease, plasma HIV RNA and CD4 cell count, over an observation time of 3 years in patients with recovered or spontaneously maintained immunocompetence. PMID: 25104966 [PubMed] (Source: AIDS Research and Therapy)
Editorial: The Monocyte/Macrophage in the Pathogenesis of AIDS: The Next Frontier for Therapeutic Intervention in the CNS and Beyond: Part II.
We present several additional articles, in Part II of this issue, further emphasizing the importance of host-virus interactions in disease and consideration for avenues of therapy and new investigation. An interesting mechanism of host dysregulation of gene expression is demonstrated here by Duan et al. where HIV-1 Tat protein impairs factalkine gene expression, leading to impaired microglial-neuronal interactions and concomitant activation of inflammation (i.e. the NFkB pathway) [3]. It is interesting to speculate that Tat, through fractalkine dysregulation, may alter the retention and migration properties of peripheral derived macrophages, and thereby contributes to the pathogenesis of HIV in CNS as well as the reservoir of infection. At the same time, down-modulation of the host-factor,...
Rwanda: My Story of Living With HIV for More Than 30 Years
[Key Correspondents]I was born with HIV and more than 30 years later I am still alive! I am sharing my story to comfort people newly infected with HIV as well as long-term survivors. Many people write about HIV but we rarely hear from people living with HIV themselves. (Source: AllAfrica News: HIV-Aids and STDs)
Implementation of a rapid HIV testing programme favourably impacts provider opinions on emergency department HIV testing
Conclusions Overall support for ED HIV testing increased after establishment of a rapid testing programme. (Source: Emergency Medicine Journal)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Hepatitis C virus core protein enhances HIV-1 replication in human macrophages through TLR2, JNK, and MEK1/2-dependent upregulation of TNF-? and IL-6
Increased progression rates to acquired immunodeficiency syndrome (AIDS) and liver disease have been reported in individuals coinfected with human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) [1,2]. Strikingly, activation of CD4+ T cells, macrophages, and dendritic cells enhances HIV-1 viral replication [3?6]. In HIV-1-infected individuals, higher viral loads and faster progression to AIDS correlate with systemic markers of immune activation [7]. Furthermore, cells latently infected by HIV-1 serve as long-lasting viral reservoirs and hinder the eradication of HIV-1 from infected patients with antiretroviral treatment. (Source: FEBS Letters)
Relating working memory to compression parameters in clinically-fit hearing aids.
Conclusions: Despite the expectation of greater variability from differences in compression implementation, number of compression channels or attendant signal processing, the relationship between working memory and compression speed showed a similar pattern as results from more controlled, laboratory-based studies. PMID: 25123548 [PubMed - as supplied by publisher] (Source: American Journal of Audiology)
Mozambique: How Country Is Coping With Aids
[IPS]Maputo -Mozambique struggles to contain the HIV epidemic with one in ten among its 24 million people infected. Helping them is not easy when only 60 percent of people have access to health services. (Source: AllAfrica News: HIV-Aids and STDs)
Zambia: Pepfar to Honour Champions Striving to Reach Every Zambian With Quality HIV Services
[Times of Zambia]SINCE the US President's Emergency Plan for AIDS Relief (PEPFAR) started working in Zambia just more than 10 years ago, dramatic progress has occurred in the fight against HIV and AIDS. (Source: AllAfrica News: HIV-Aids and STDs)
Tanzania: HIV Infection Among Drug Users High in Zanzibar
[Daily News]Zanzibar -AT least 67 people among drug users in Zanzibar tested HIV positive last year, an indication that the spread of the deadly virus among the group needed addressing. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Nigeria: Yemi Alade to Fight Cancer, Aids Through Social Media
[Daily Independent]Nigerian artiste, Yemi Alade, says she plans to create an awareness campaign to help women fight cervical cancer, HIV/AIDS and other diseases, which affect women. (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: Too Trusting Population Hampers Aids Prevention
[Capital FM]Nairobi -Don't stare, we're told. Also, "if you come across your relative, don't see them until they see you," Dr Kenneth Ngure tells us. (Source: AllAfrica News: HIV-Aids and STDs)
Which dimensions of disability does the HIV Disability Questionnaire (HDQ) measure? A factor analysis.
Conclusions: The HDQ has six domains: physical symptoms and impairments; cognitive symptoms and impairments; mental and emotional health symptoms and impairments; uncertainty; difficulties with day-to-day activities and challenges to social inclusion. These domains establish the scoring structure for the dimensions of disability measured by the HDQ. Implications for Rehabilitation As individuals live longer and age with HIV, they may be living with the health-related consequences of HIV and concurrent health conditions, a concept that may be termed disability. Measuring disability is important to understand the impact of HIV and its comorbidities. The HIV Disability Questionnaire (HDQ) is a self-administered questionnaire developed to describe the presence, severity and episodic nature of ...
Anthropometry and body composition of vertically HIV-infected children and adolescents under therapy with and without protease inhibitors.
CONCLUSIONS: The findings of the study suggest that children and adolescents under protease inhibitors are at higher risk of growth and development deviations, but not at risk of body fat redistribution. PMID: 25115797 [PubMed - as supplied by publisher] (Source: Public Health Nutrition)
Social Participation of School-aged Children Who Use Communication Aids: The Views of Children and Parents.
This article presents findings from interviews with eight 5- to 14-year-old children who used communication aids and their parents about social participation, communicative interactions, and peer relationships. Video- and audio-recordings were transcribed and analyzed using thematic content analysis, and five themes were identified. Two themes reflect parents' views: Communication partners and strategies and Access to aided communication. Three themes reflect perceptions expressed both by children and parents: Participation in society, Interaction opportunities, and Social relationships. The findings provide insights into both the achievements and the challenges experienced by young people who use aided communication. PMID: 25115791 [PubMed - as supplied by publisher] (Source: Augmenta...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Space Oddity: Use of Sleep Aids in Astronauts Astronomical Space Oddity: Use of Sleep Aids in Astronauts Astronomical
Sleep deficiency is pervasive among astronauts before and during space flight, and the reported incidence sleep-promoting medication use is 20 times greater than the proportion of Americans estimated to use hypnotic drugs at any time in a given year. Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Stigma Is a Side-Effect of HIV-Prevention MedicineStigma Is a Side-Effect of HIV-Prevention Medicine
Truvada is a drug that can help people who are not infected avoid contracting the virus that causes AIDS. But some patients are worried the medical community is not up to speed. Kaiser Health News (Source: Medscape Medical News Headlines)
Breaking Open Public Places: UNFPA Launches Coolibah - 21 July 2014
MELBOURNE, Australia &ndash; At the International AIDS Conference 2014 today, UNFPA, the United Nations Population Fund, launched a youth networking zone called the coolibah, where, throughout the week, it will host a range of activities for and with young people, including a series of luncheons with leaders in the field of HIV and AIDS. (Source: UNFPA News)
UNFPA engages young people in the fight against HIV - 21 July 2014
MELBOURNE, Australia &ndash; Every hour, about 80 young people are newly infected with HIV, according to the recently released Gap Report by UNAIDS. The participation and leadership of young people will therefore be critical in bringing the global HIV epidemic to an end. Today, at the 20th International AIDS Conference, UNFPA launched a youth networking zone called the &lsquo;coolibah&rsquo;, where young people will be able to speak with leaders in the field of HIV and AIDS. (Source: UNFPA News)
Premature baby&#039;s shrill cry may be sign of something deeper
Higher pitch could indicate lower activities in nerve that aids digestion (Source: ScienceNOW)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
South Africa: Report - South African National Aids Council Annual Performance Plan 2014-15
[Health-e]The South African National AIDS Council (SANAC) outlines its plan for the next three years in this 8-page performance plan. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: Why Male Circumcision Is a Key Weapon in Tackling Aids
[The Herald]Transformative change is afoot among men and boys throughout Southern and Eastern Africa. Millions have bravely stepped up to protect themselves and their partners from HIV. (Source: AllAfrica News: HIV-Aids and STDs)
Rwanda: Lab Services to Be At Centre of HIV/Aids Fight
[New Times]Milk remains a key source of nutrients to fight stunting among children. Taking milk results into good mental and physical development. As far its composition is concerned, this wonder food is rich in proteins, vitamins A, B, B12, nutrients that contribute to strong and healthy bones. This was said by a health and nutritional specialist by the Global Communities/Usaid Ejo Heza while launching a milk campaign targeting lactating mothers and children in Gisagara District last week. (Source: AllAfrica News: HIV-Aids and STDs)
Rwanda: How Truvada ARVs Breed Reckless Sexual Lifestyle
[New Times]Taking care of an HIV patient can be one of the most challenging tasks but not for Suzan Mukandoli, who did not just sit back to watch her elder brother die in agony. Every morning she would make it a point to dress up his wound on the leg and thereafter administer medication. (Source: AllAfrica News: HIV-Aids and STDs)
Breaking Open Public Places: UNFPA Launches Coolibah - 21 July 2014
MELBOURNE, Australia &ndash; At the International AIDS Conference 2014 today, UNFPA, the United Nations Population Fund, launched a youth networking zone called the coolibah, where, throughout the week, it will host a range of activities for and with young people, including a series of luncheons with leaders in the field of HIV and AIDS. (Source: UNFPA News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
UNFPA engages young people in the fight against HIV - 21 July 2014
MELBOURNE, Australia &ndash; Every hour, about 80 young people are newly infected with HIV, according to the recently released Gap Report by UNAIDS. The participation and leadership of young people will therefore be critical in bringing the global HIV epidemic to an end. Today, at the 20th International AIDS Conference, UNFPA launched a youth networking zone called the &lsquo;coolibah&rsquo;, where young people will be able to speak with leaders in the field of HIV and AIDS. (Source: UNFPA News)
Perception of High School Students on risk for acquiring HIV and utilization of Voluntary Counseling and Testing (VCT) service for HIV in Debre-berhan Town, Ethiopia: a quantitative cross-sectional study
Conclusions: Some students were engaged in risky sexual behavior even though they had heard about HIV/AIDS. The perception of risk for acquisition of HIV infection and utilization of VCT were low. Thus, education on topic of HIV/AIDS through integrating as part of school curriculum and encouraging the existing health institutions to provide youth-friendly sexual counseling services including VCT for HIV are strongly recommended. (Source: BMC Research Notes)
Abacavir/lamivudine plus darunavir/ritonavir in routine clinical practice: a multicentre experience in antiretroviral therapy-naive and -experienced patients
Conclusions In our cohort, abacavir/lamivudine + darunavir/ritonavir was safe, well tolerated and achieved high rates of virological suppression. In a proportion of patients, discontinuation of this effective regimen was possibly due to non-medical reasons. (Source: Journal of Antimicrobial Chemotherapy)
Highlights from this issue
In an era of scarce resources, how can we best target prevention activities and screening? This month, Simms and colleagues address this question in an editorial exploring the potential contribution of geographic information systems (GIS) to sexual health research.1 This is a perennial problem, but new technologies may hold potential for improved targeting of resources without compromising confidentiality. This is definitely worth a read for colleagues working with commissioners to plan their services. The British Association for Sexual Health and HIV (BASHH) has revised its standards for the management of sexually transmitted infections, originally published in collaboration with the Medical Foundation for HIV and Sexual Health in 2010. Lowbury and Ahmed-Jushuf introduce this new edition ...
Standards for the management of sexually transmitted infections--2014
Despite progress in recent years the UK continues to have high rates of sexually transmitted infections (STIs), with some population groups disproportionately at risk of poor sexual health. It is widely accepted that effective commissioning of services and interventions is key to improving health outcomes. To support commissioners and providers in this aim and to help them achieve high quality services for the populations they serve, the British Association for Sexual Health and HIV, and MEDFASH (Medical Foundation for HIV & Sexual Health) have comprehensively revised and updated the Standards for the management of STIs,1 originally published in 2010. There has been a momentous change across the health commissioning landscape in England since the original standards were launched. Local...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
HIV and sexually transmitted infection-related risks among female sex workers in Mongolia: second-generation surveillance survey, 2011-2012
Conclusions A syphilis epidemic continues to grow among FSWs in Mongolia. These women are at high risk of HIV transmission if introduced into their sexual networks. With the increase in migration of mining workers in Mongolia, introduction of HIV may be imminent. Efforts to intensify treatment and prevention programmes among FSWs are needed. (Source: Sexually Transmitted Infections)
Strategies for promoting HIV testing uptake: willingness to receive couple-based and collective HIV testing among a cross-sectional online sample of men who have sex with men in China
We examined the potential usefulness of couple-based and collective HIV testing strategies among Chinese MSM. Methods A cross-sectional online survey was conducted among 1113 MSM in 2013. Multivariable logistic regression analyses were conducted to identify factors associated with willingness to receive couple-based and collective testing. Results Acceptability of couple-based testing was very high among participants (86.1%), with a moderate level of interest in collective testing (43.2%). Being &lsquo;out&rsquo; to others about one's sexual identity (adjusted OR (AOR)=1.48, 95% CI 1.01 to 2.17) and having ever had an HIV test (AOR=3.05, 95% CI 2.10 to 4.33) were associated with willingness to receive couple-based testing. Having multiple male anal sex partners in the past 3&nbsp;months ...
Sexual risk typologies and their relationship with early parenthood and STI outcomes among urban African-American emerging adults: a cross-sectional latent profile analysis
Conclusions LCA identified distinct risk clusters that predicted sexual health outcomes and can inform targeted interventions for a minority youth population disproportionately affected by HIV, other STIs, and early parenthood. (Source: Sexually Transmitted Infections)
The effect of mobility on sexual risk behaviour and HIV infection: a cross-sectional study of men who have sex with men in southern India
Conclusions Mobile MSM have a higher likelihood of contracting HIV. Interventions extending the ways to reach out to MSM with greater mobility may augment ongoing efforts to reduce the spread of HIV/AIDS in India. (Source: Sexually Transmitted Infections)
Prevalence, correlates and trends in seroadaptive behaviours among men who have sex with men from serial cross-sectional surveillance in San Francisco, 2004-2011
Conclusions HIV seroadaptive behaviours remain common in San Francisco MSM, have increased in the last decade and are practiced differently by MSM with different sexual health knowledge and outcomes. Public health researchers and officials should continue to document the prevalence, intentionality, efficacy and safety of seroadaptive behaviours among diverse communities of MSM. (Source: Sexually Transmitted Infections)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
A stair-climbing test for measuring mechanical efficiency of ambulation in adults with chronic stroke.
Conclusion: With a minimal detectable change of 0.6% (0.053 of average MEnet score of 10.4%), MEnet values from the stair-climbing test seem sufficiently meaningful to estimate ambulatory ability and its changes with interventions or walking aids in adults with hemiparesis. Implications for Rehabilitation Ambulatory ability can be estimated from mechanical efficiency, obtained from a 5-min stair-climbing test utilizing a 4-step stair, to measure external work, and the change in heart rate above rest to estimate the metabolic cost of the task. A change of &gt;?0.6% in mechanical efficiency by this stair-climbing test indicates a significant change in ambulatory ability of persons with hemiparesis. PMID: 25113573 [PubMed - as supplied by publisher] (Source: Disability and Rehabilitatio...
Discovery of a novel HIV-1 integrase inhibitor from natural compounds through structure based virtual screening and cell imaging
Human immunodeficiency virus (HIV) is the virus that causes the fatal acquired immunodeficiency syndrome (AIDS) [1]. The HIV life cycle is usually divided into six steps: attachment and fusion, reverse transcription, integration of viral DNA into host genome, transcription, assembly and budding [2,3]. Integrase, also called p31, is the enzyme responsible for integration. Integrase is consisted of three domains: N-termianl domain (NTD, residues 1?49), catalytic core domain (CCD, residues 50?212) and C-terminal domain (CTD, residues 213?288) [4]. (Source: FEBS Letters)
Tuberculosis Infection Control: Potential Benefit of a New Rapid Tuberculosis Test in a Human Immunodeficiency Virus/AIDS Reference Hospital
Marcelo Cordeiro-Santos, MD, PhD; Anete Trajman, MD, PhD; Frank Cobelens, MD PhD; Betina Durovni, MD; Maurício Gonçalves, MSc; Samira Bührer-Sékula, PhD; Valeria Saraceni, MD PhD Infection Control and Hospital Epidemiology, Volume 35, Issue 9, Page 1206-1207, September 2014. (Source: Infect Control Hosp Epidemiol Latest Issue)
Generation and Characterization of an HIV-1 Subtype C Transmitted and Early Founder Virus Consensus Sequence
AIDS Research and Human Retroviruses , Vol. 0, No. 0. (Source: AIDS Research and Human Retroviruses)
Melanocyte Biology and Function with Reference to Oral Melanin Hyperpigmentation in HIV-Seropositive Subjects
AIDS Research and Human Retroviruses , Vol. 0, No. 0. (Source: AIDS Research and Human Retroviruses)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Impact of an Adherence Program to Antiretroviral Treatment on Virologic Response in a Cohort of Multitreated and Poorly Adherent HIV-Infected Patients in Spain
AIDS Patient Care and STDs , Vol. 0, No. 0. (Source: AIDS Patient Care and STDs)
Marurani Update!
Ten. The number of days we have left to squeeze in community day, the rest of our testings, and as many teachings as possible. The number of days we have left in the village. The number of days we have left in Tanzania. It?s safe to say that this number shocks all of us and it?s hard to believe that of the two months we started with, ten days is all that remains. While we?ve been here, we?ve taught a huge variety of people, at a huge variety of places. We?ve taught at schools, soccer pitches, farms, pubs, churches, mama?s groups, investing groups, and people simply standing by the side of the road. And all the while, even though we came as outsiders, we were welcomed by our home stay families and the entire village as some of their own. All of this has caused the last seven wee...
Seeing Through Virtual Touch for Vision Impaired
Visual impairment comes in many forms, and it's on the rise in America. (Source: Disabled World)
Kenya: Widows in Kenya Tackle HIV in Their Community
[Key Correspondents]When Jacinta Mulatia tested positive for HIV in 2003 it came as a shock to her, she was confused and unsure what to do when faced with extreme stigma in her community. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: South Africa Leads in HIV Prevention Among Gay Groups
[GroundUp]As homophobic discrimination continues to sweep across the African continent, we should be acutely mindful of the diverse ways it harms societies. While we are most aware of the direct effect homophobic physical violence has on sexual minority groups, it is also crucial that we be cognisant of the many insidious ways stigma and discrimination impact not only on sexual minorities but society at large. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Breaking Open Public Places: UNFPA Launches Coolibah - 21 July 2014
MELBOURNE, Australia &ndash; At the International AIDS Conference 2014 today, UNFPA, the United Nations Population Fund, launched a youth networking zone called the coolibah, where, throughout the week, it will host a range of activities for and with young people, including a series of luncheons with leaders in the field of HIV and AIDS. (Source: UNFPA News)
UNFPA engages young people in the fight against HIV - 21 July 2014
MELBOURNE, Australia &ndash; Every hour, about 80 young people are newly infected with HIV, according to the recently released Gap Report by UNAIDS. The participation and leadership of young people will therefore be critical in bringing the global HIV epidemic to an end. Today, at the 20th International AIDS Conference, UNFPA launched a youth networking zone called the &lsquo;coolibah&rsquo;, where young people will be able to speak with leaders in the field of HIV and AIDS. (Source: UNFPA News)
Africa: Stigma Still a Major Roadblock for Aids Fight in Africa
[IPS]Washington -Though West Africa's massive Ebola outbreak may be dominating the spotlight within the global health community, HIV/AIDS remains an enormous issue for Africa as a whole - a sentiment that Washington officials made clear this week in their discussions of legislative and technological setbacks plaguing progress in fighting the epidemic. (Source: AllAfrica News: Health and Medicine)
Nigeria: Man Stabs Wife to Death, Says 'She Infested Him With HIV'
[Daily Independent]Lagos -Officers of the homicide section of the Criminal Investigations Department, Lagos State Police Command, Yaba, led by Dan Iyama, a Chief Superintendent of Police, (CSP) are trying to unravel the real motive behind the killing of a woman, named Justina James, by a suspect- Katongu Philip, 45. (Source: AllAfrica News: HIV-Aids and STDs)
Adherence Pattern to a Daily Oral Pre-exposure ProphylaxisAdherence Pattern to a Daily Oral Pre-exposure Prophylaxis
What factors are associated with good adherence to daily, oral HIV pre-exposure prophylaxis? JAIDS: Journal of Acquired Immune Deficiency Syndromes (Source: Medscape Today Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Helping Our Patients Take HIV Pre-Exposure ProphylaxisHelping Our Patients Take HIV Pre-Exposure Prophylaxis
What strategies could promote adherence to HIV pre-exposure prophylaxis? HIV Medicine (Source: Medscape Today Headlines)
Cryptococcal Antigen Positivity Among AIDS PatientsCryptococcal Antigen Positivity Among AIDS Patients
How common is undiagnosed cryptococcal infection in patients with HIV? Morbidity & Mortality Weekly Report (Source: Medscape Today Headlines)
Drug Resistance Among Newly Diagnosed HIV-Infected ChildrenDrug Resistance Among Newly Diagnosed HIV-Infected Children
How should drug resistance in HIV-infected infants and young children be managed? AIDS (Source: Medscape Today Headlines)
Nigeria: HIV/Aids Prevalence Drops in a/Ibom - SACA
[Leadership]The Human Immuno-deficiency Virus and the Acquired Immune Deficiency Syndrome (HIV/AIDS) prevalence rate has dropped in Akwa Ibom State. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: Youth Council Organises HIV/Aids Sensitisation Workshop
[Independent]The National Youth Council of Nigeria (NYCN), Cross River chapter, has organised a sensitisation workshop on the Human Immunodeficiency Virus and Acquired Immune Deficiency Syndrome HIV/AIDS as part of activities to mark the 2014 International Youth Week celebration. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Pleuropericardial effusion: a diagnostic conundrum
Pleuropericardial effusion as a presenting feature raises the possibility of infectious, neoplastic and connective tissue disorders.1 However, unusual pathophysiological mechanisms may sometimes pose a diagnostic conundrum in certain clinical contexts. Simultaneous pleuropericardial effusion secondary to obstructive uropathy is such a rare scenario with no report mentioned in the published literature. A 62-year-old man presented with progressive dyspnoea and left flank pain for 1&nbsp;month. A CT scan revealed massive left-sided effusion, mild pericardial effusion (figure 1A,B) and a large staghorn calculi in the left kidney causing grade 4 hydronephrosis (figure 2A,B). Therapeutic thoracentesis revealed a straw-coloured transudative effusion with sugar of 44&nbsp;mg/dL, lactate dehydrogen...
How do supply?side factors influence informal payments for healthcare? The case of HIV patients in Cameroon

Comparison of the benefits of cochlear implantation versus contra-lateral routing of signal hearing aids in adult patients with single-sided deafness: study protocol for a prospective within-subject longitudinal trial
DiscussionThis multi-centre trial was designed to provide evidence for the efficacy of cochlear implantationcompared to the contra-lateral routing of signals. A purpose-built sound presentation system andestablished measurement techniques will provide reliable and precise measures of binaural hearing.Trial RegistrationCurrent Controlled Trials ISRCTN33301739 http://www.controlled-trials.com/ISRCTN33301739 (07/JUL/2013) (Source: BMC Ear, Nose and Throat Disorders)
Infection of the optic apparatus and hypothalamus by Mycobacterium haemophilum
We present a case of M haemophilum infection of the optic chiasm, tract, and hypothalamus in a patient with AIDS. (Source: Neurology)
Incidence and risk factors for AIDS-related mortality in HIV patients in China: a cross-sectional study
Conclusions: The effective reduction of AIDS mortality could be improved through timely treatment. (Source: BMC Public Health - Latest articles)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Structural insights for HIV-1 therapeutic strategies targeting Vif.
Authors: Salter JD, Morales GA, Smith HC Abstract HIV-1 viral infectivity factor (Vif) is a viral accessory protein that is required for HIV-1 infection due largely to its role in recruiting antiretroviral factors of the APOBEC3 (apolipoprotein B editing catalytic subunit-like 3) family to an E3 ubiquitin ligase complex for polyubiquitylation and proteasomal degradation. The crystal structure of the (near) full-length Vif protein in complex with Elongin (Elo)B/C, core-binding factor (CBF)? and Cullin (Cul)5 revealed that Vif has a novel structural fold. In our opinion the structural data revealed not only the protein-protein interaction sites that determine Vif stability and interaction with cellular proteins, but also motifs driving Vif homodimerization, which are essential in Vi...
Over-the-counter and Prescription Sleep Medication and Incident Stroke: The REasons for Geographic And Racial Differences in Stroke Study
Conclusions: Over-the-counter sleep medication use may independently increase the risk of stroke beyond other risk factors in middle-aged to older individuals with no history of stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Breaking Open Public Places: UNFPA Launches Coolibah - 21 July 2014
MELBOURNE, Australia &ndash; At the International AIDS Conference 2014 today, UNFPA, the United Nations Population Fund, launched a youth networking zone called the coolibah, where, throughout the week, it will host a range of activities for and with young people, including a series of luncheons with leaders in the field of HIV and AIDS. (Source: UNFPA News)
UNFPA engages young people in the fight against HIV - 21 July 2014
MELBOURNE, Australia &ndash; Every hour, about 80 young people are newly infected with HIV, according to the recently released Gap Report by UNAIDS. The participation and leadership of young people will therefore be critical in bringing the global HIV epidemic to an end. Today, at the 20th International AIDS Conference, UNFPA launched a youth networking zone called the &lsquo;coolibah&rsquo;, where young people will be able to speak with leaders in the field of HIV and AIDS. (Source: UNFPA News)
Egypt?s Poor Easy Victims of Quack Medicine
Many pharmacies and herbalists in Egypt prescribe their own 'wasfa' (secret drug or herbal elixir). Credit: Cam McGrath/IPSBy Cam McGrathCAIRO, Aug 10 2014 (IPS) Magda Ibrahim first learnt that she had endometrial cancer when she went to a clinic to diagnose recurring bladder pain and an abnormal menstrual discharge. Unable to afford the recommended hospital treatment, the uninsured 53-year-old widow turned to what she hoped would be a quicker and cheaper therapy. A local Muslim sheikh claimed religious incantations, and a suitable donation to his pocket, could cure the cancer. But when her symptoms persisted, Ibrahim consulted a popular herbalist, whose wasfa (secret drug or herbal elixir) was reputed to shrink tumours. ?I felt much better for a few months and thought the tumour was shr...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Breaking Open Public Places: UNFPA Launches Coolibah - 21 July 2014
MELBOURNE, Australia &ndash; At the International AIDS Conference 2014 today, UNFPA, the United Nations Population Fund, launched a youth networking zone called the coolibah, where, throughout the week, it will host a range of activities for and with young people, including a series of luncheons with leaders in the field of HIV and AIDS. (Source: UNFPA News)
UNFPA engages young people in the fight against HIV - 21 July 2014
MELBOURNE, Australia &ndash; Every hour, about 80 young people are newly infected with HIV, according to the recently released Gap Report by UNAIDS. The participation and leadership of young people will therefore be critical in bringing the global HIV epidemic to an end. Today, at the 20th International AIDS Conference, UNFPA launched a youth networking zone called the &lsquo;coolibah&rsquo;, where young people will be able to speak with leaders in the field of HIV and AIDS. (Source: UNFPA News)
Optimal starting point for antiretroviral HIV treatment in a town in Cameroon: a randomised controlled study
Conclusions: In our small sample, relative risk for death did not differ significantly, but deferred treatment seemed to carry no increased survival or other clinical advantage. During the study period, other studies made WHO change its guidelines to conform to our early treatment. The tendency in our study lends support to this policy.Trial registration: ISRCTN22114173 (Source: Epidemiologic Perspectives and Innovations)
Breaking Open Public Places: UNFPA Launches Coolibah - 21 July 2014
MELBOURNE, Australia &ndash; At the International AIDS Conference 2014 today, UNFPA, the United Nations Population Fund, launched a youth networking zone called the coolibah, where, throughout the week, it will host a range of activities for and with young people, including a series of luncheons with leaders in the field of HIV and AIDS. (Source: UNFPA News)
UNFPA engages young people in the fight against HIV - 21 July 2014
MELBOURNE, Australia &ndash; Every hour, about 80 young people are newly infected with HIV, according to the recently released Gap Report by UNAIDS. The participation and leadership of young people will therefore be critical in bringing the global HIV epidemic to an end. Today, at the 20th International AIDS Conference, UNFPA launched a youth networking zone called the &lsquo;coolibah&rsquo;, where young people will be able to speak with leaders in the field of HIV and AIDS. (Source: UNFPA News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
AIDS in Black and White: The Influence of Newspaper Coverage of HIV/AIDS on HIV/AIDS Testing Among African Americans and White Americans, 1993&#8211;2007
(Source: Journal of Health Communication)
A combined chemometric and quantitative NMR analysis of HIV/AIDS serum discloses metabolic alterations associated with disease status
Mol. BioSyst., 2014, Advance ArticleDOI: 10.1039/C4MB00347K, PaperTracy R. McKnight, Hikari A. I. Yoshihara, Lungile J. Sitole, Jeffery N. Martin, Francois Steffens, Debra MeyerCombined chemometric and quantitative analysis of NMR spectra from HIV-infected sera disclosed previously unknown associations between specific metabolites, such as alanine, and disease status.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Mol. BioSyst. latest articles)
Prevalence of dizziness in older people
Conclusion we conclude that dizziness is a very prevalent symptom in the elderly, coexisting with co-morbidities and use of multiple medications. (Source: Revista CEFAC)
Hearing aids dispensed by sus and quality of life
Conclusion 60% of adults and 46% of elderly use hearing aids and present satisfactory quality of life. (Source: Revista CEFAC)
Breaking Open Public Places: UNFPA Launches Coolibah - 21 July 2014
MELBOURNE, Australia &ndash; At the International AIDS Conference 2014 today, UNFPA, the United Nations Population Fund, launched a youth networking zone called the coolibah, where, throughout the week, it will host a range of activities for and with young people, including a series of luncheons with leaders in the field of HIV and AIDS. (Source: UNFPA News)
UNFPA engages young people in the fight against HIV - 21 July 2014
MELBOURNE, Australia &ndash; Every hour, about 80 young people are newly infected with HIV, according to the recently released Gap Report by UNAIDS. The participation and leadership of young people will therefore be critical in bringing the global HIV epidemic to an end. Today, at the 20th International AIDS Conference, UNFPA launched a youth networking zone called the &lsquo;coolibah&rsquo;, where young people will be able to speak with leaders in the field of HIV and AIDS. (Source: UNFPA News)
Stigma Still a Major Roadblock for AIDS Fight in Africa
Rwandan children orphaned by AIDS in Muhanga village. Credit: Aimable Twahirwa/IPSBy Julia HotzWASHINGTON, Aug 9 2014 (IPS) Though West Africa?s massive Ebola outbreak may be dominating the spotlight within the global health community, HIV/AIDS remains an enormous issue for Africa as a whole &#8211; a sentiment that Washington officials made clear this week in their discussions of legislative and technological setbacks plaguing progress in fighting the epidemic. Despite the World Health Organisation?s announcement Friday that Ebola is now an ?international public health emergency,? doctors, academics and policymakers met Thursday at the Washington office of Kaiser Family Foundation (KFF), a health-policy non-profit, to discuss the similarly urgent threat posed by HIV/AIDS, the su...
Table of Contents
(Source: Journal of the Association of Nurses in AIDS Care)
Editorial Board
(Source: Journal of the Association of Nurses in AIDS Care)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Cover 1
(Source: Journal of the Association of Nurses in AIDS Care)
Position Statement: Advanced Practice Registered Nurses Full Practice Authority
It is the position of the Association of Nurses in AIDS Care that: (Source: Journal of the Association of Nurses in AIDS Care)
Retention in Care: Lessons Relearned
When we try to pick out anything by itself we find that it is bound fast, by a thousand invisible cords that cannot be broken, to everything in the universe.John Muir (1838-1914; Fox, 1981, p. 291). (Source: Journal of the Association of Nurses in AIDS Care)
Masthead
(Source: Journal of the Association of Nurses in AIDS Care)
Board of Directors
(Source: Journal of the Association of Nurses in AIDS Care)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Neurodevelopmental outcomes in HIV-exposed-uninfected children versus those not exposed to HIV
(Source: AIDS Care)
Orphan/vulnerable child caregiving moderates the association between women's autonomy and their BMI in three African countries
(Source: AIDS Care)
Site migration in seeking care services from multiple providers is associated with worse clinical outcomes among HIV-infected individuals in Washington, DC
(Source: AIDS Care)
Treatment retention and care transitions during and after the scale-up of HIV care and treatment in Northern Tanzania
(Source: AIDS Care)
Prevalence and correlates of willingness to participate in a rectal microbicide trial among men who have sex with men in Bangkok
(Source: AIDS Care)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Mental health of patients with human immunodeficiency virus in Japan: a comparative analysis of employed and unemployed patients
(Source: AIDS Care)
High prevalence of suicide risk in people living with HIV: who is at higher risk?
(Source: AIDS Care)
Contagiousness under antiretroviral therapy and stigmatization toward people with HIV
(Source: AIDS Care)
Associations between physical activity and sedentary time on components of metabolic syndrome among adults with HIV
(Source: AIDS Care)
Poor retention in care one-year after viral suppression: a significant predictor of viral rebound
(Source: AIDS Care)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Simple, illustrated medicines information improves ARV knowledge and patient self-efficacy in limited literacy South African HIV patients
(Source: AIDS Care)
HIV-related behavioral risk factors among older female sex workers in Guangxi, China
(Source: AIDS Care)
Evidence of increased STI/HIV-related risk behavior among male perpetrators of intimate partner violence in Guatemala: results from a national survey
(Source: AIDS Care)
Gender differences in HIV disclosure, stigma, and perceptions of health
(Source: AIDS Care)
Psychosocial burdens negatively impact HIV antiretroviral adherence in gay, bisexual, and other men who have sex with men aged 50 and older
(Source: AIDS Care)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Survey of HIV care providers on management of HIV serodiscordant couples &#8211; assessment of attitudes, knowledge, and practices
(Source: AIDS Care)
Factors associated with inconsistent condom use in adolescents with negative or unknown HIV status in Northwest Cameroon
(Source: AIDS Care)
Treatment as prevention: are Argentinean HIV care providers willing to adopt earlier antiretroviral therapy?
(Source: AIDS Care)
Theoretical model of critical issues in informed consent in HIV vaccine trials
(Source: AIDS Care)
Editorial: The Monocyte/Macrophage in the Pathogenesis of AIDS: The Next Frontier for Therapeutic Intervention in the CNS and Beyond: Part I.
Authors: Rappaport J Abstract Monocytes, macrophages, and microglia, play multiple roles in the pathogenesis of HIV infection. In addition to providing a tissue reservoir of infection, HIV infected and non-infected macrophages enter and accumulate in the Central Nervous System, where virus infection spreads to resident glial cells including astrocytes and microglia. This process contributes to the secretion of toxic molecules and inflammatory cytokines, which contribute to neuronal damage and promote a spectrum of HIVassociated neurological disorders ranging from HIV dementia to asymptomatic neurocognitive impairment. There appears to be an alteration in the dynamics of monocyte/macrophage subsets as a result of HIV infection, with resulting alterations in immune polarization statu...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Switching Antiretrovirals May Not Enhance HIV TreatmentSwitching Antiretrovirals May Not Enhance HIV Treatment
Changing treatment when the viral load is suppressed can increase the risk for subsequent virologic failure, new research shows. Medscape Medical News (Source: Medscape Hiv-Aids Headlines)
Tanzania: Women Lobby Male Partners to Be Circumcised
[AlertNet]Dar es Salaam -Efrazia Ngwabi has been trying to encourage her husband to get circumcised but her efforts have been hampered by his belief that the practice is against tribal tradition. (Source: AllAfrica News: HIV-Aids and STDs)
Viral Reservoir Seen 'Strikingly' Soon After HIV InfectionViral Reservoir Seen 'Strikingly' Soon After HIV Infection
A reservoir of HIV is established much sooner after infection than was previously thought; measuring that reservoir is the next big challenge. Medscape Medical News (Source: Medscape Today Headlines)
Namibia: MOHSS Awards Multi-Million Tenders
[New Era]Windhoek -HIV-positive patients will soon start taking fixed-dose combination anti-retroviral (ARV) medication, which involves one tablet instead of three to five pills a day, reducing the risk of patients defaulting on their treatment. (Source: AllAfrica News: HIV-Aids and STDs)
Namibia: HIV, Aids Awareness Exhibit Due
[New Era]Windhoek -The Legal Assistance Centre (LAC) will be hosting an exhibition titled Break the Silence an exhibition of international artworks, raising awareness on HIV and AIDS with the collection facilitated by the organization Artists for Human Rights (AFHR). (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Africa: U.S., London Foundation Boost Help for African Children With HIV
[State Department]Washington -The U.S. President's Emergency Plan for AIDS Relief (PEPFAR), in partnership with the Children's Investment Fund Foundation (CIFF), launched Accelerating Children's HIV/AIDS Treatment (ACT) on August 6 during the U.S.-Africa Leaders Summit. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: Investments Announced At Symposium for African Spouses
[White House]Washington, DC -INVESTMENTS ANNOUNCED AT SYMPOSIUM FOR AFRICAN SPOUSES (Source: AllAfrica News: HIV-Aids and STDs)
South Africa: Searching for Acceptance
[Health-e]Telling your family you are gay is hard. It may be harder in rural small-town South Africa. (Source: AllAfrica News: HIV-Aids and STDs)
Uganda: Kenya Overtaking Uganda in HIV/Aids Management
[Observer]Once touted as the success story of not just the continent, but the world, Uganda seems to be slipping further off that decorated wagon and paving way for new golden girls such as Kenya. (Source: AllAfrica News: HIV-Aids and STDs)
Malawi: Key Stakeholders Should Be Involved in Srh to Reduce HIV/Aids Transmission - VSO
[Malawi News Agency]Nsanje -NGO Voluntary Service Overseas (VSO) has made a bold proclamation that the country cannot make progress in reducing HIV/AIDS transmission among women and adolescent girls unless all key players are fully involved in providing Sexual and Reproductive Health Rights (SRH) services to them. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Proximal Renal Tubular Dysfunction Related to Antiretroviral Therapy Among HIV-Infected Patients in an HIV Clinic in Mexico
AIDS Patient Care and STDs , Vol. 0, No. 0. (Source: AIDS Patient Care and STDs)
Response of discharge, TSS, and E. coli to rainfall events in urban, suburban, and rural watersheds
Environ. Sci.: Processes Impacts, 2014, Advance ArticleDOI: 10.1039/C4EM00327F, PaperH. J. Chen, H. ChangUnderstanding dominant processes influencing microorganism responses to storm events aids in the development of effective management controls on pathogen contamination in surface water so that they are suitable for water supply, recreation, and aquatic habitat.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - J. Environ. Monit. latest articles)
Breaking Open Public Places: UNFPA Launches Coolibah - 21 July 2014
MELBOURNE, Australia &ndash; At the International AIDS Conference 2014 today, UNFPA, the United Nations Population Fund, launched a youth networking zone called the coolibah, where, throughout the week, it will host a range of activities for and with young people, including a series of luncheons with leaders in the field of HIV and AIDS. (Source: UNFPA News)
UNFPA engages young people in the fight against HIV - 21 July 2014
MELBOURNE, Australia &ndash; Every hour, about 80 young people are newly infected with HIV, according to the recently released Gap Report by UNAIDS. The participation and leadership of young people will therefore be critical in bringing the global HIV epidemic to an end. Today, at the 20th International AIDS Conference, UNFPA launched a youth networking zone called the &lsquo;coolibah&rsquo;, where young people will be able to speak with leaders in the field of HIV and AIDS. (Source: UNFPA News)
College students' search for sexual health information from their best friends: An application of the theory of motivated information management
Guided by the theory of motivated information management, this study investigated the extent to which Singaporean college students' sexual health information?seeking behaviour could be accounted for by their anxiety of uncertainty discrepancy, their perceived outcomes of information seeking and their perceived confidence in seeking and coping with sexual health information acquired from their best friends. Taking into account that issue relevance may play a role in individuals' health decision?making, this study also examined the effect of perceived vulnerability on respondents' sexual health information?seeking behaviour. An online survey was conducted with 202 undergraduate students at a university in Singapore. Respondents were asked to report the frequency with which they sought ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Corrigendum
(Source: AIDS Care)
Stage-Stratified Approach to AIDS-Related Kaposi's Sarcoma: Implications for Resource-Limited Environments [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Risk of Cataract among Subjects with Acquired Immune Deficiency Syndrome Free of Ocular Opportunistic Infections
To evaluate the risk of cataract in the setting of AIDS. (Source: Ophthalmology)
The Moderating Role of Sexual Identity in Group Teletherapy for Adults Aging with HIV.
This study examined whether therapy attendance rates and the efficacies of two group-format teletherapies for the treatment of depression (coping effectiveness group training and supportive-expressive group therapy) were comparable for older MSM and older heterosexuals living with HIV. Intervention-outcome analyses found that older MSM and older heterosexuals living with HIV attended comparable numbers of teletherapy sessions. Older heterosexuals living with HIV who received telephone-administered supportive-expressive group therapy reported significantly greater reductions in depressive symptoms than SOC controls. A similar pattern was not found in older MSM. More research is needed to personalize and tailor group teletherapies for older MSM living with HIV. PMID: 25090366 [PubMed - ...
Aging and HIV/AIDS: Neurocognitive Implications for Older HIV-Positive Latina/o Adults.
This study examined the effects of age and ethnicity on NC function in HIV-positive adults. The sample (N = 126; 84 Latina/o and 42 Non-Hispanic White) completed a comprehensive NC battery. Global NC and domain average demographically-corrected t-scores were generated. There were no significant differences between Younger (&lt;50 years) Latina/os and non-Hispanic Whites on Global NC function or NC domains (all p's &gt;.10), with generally small effect sizes. Older Latina/os (?50 years) were significantly more impaired than Older Non-Hispanic Whites on processing speed and learning, with trends in Global NC function and memory. Further, effect sizes fell within the medium to large range (Cohen's d's = .49-1.15). This study suggests that older Latina/os are at potentially greater risk fo...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Substance Use and Sexual Risk Differences among Older Bisexual and Gay Men with HIV.
Authors: Brennan-Ing M, Porter KE, Seidel L, Karpiak SE Abstract Bisexual and gay men are disproportionately affected by HIV/AIDS. Research typically combines these groups into the category of men who have sex with men, and little is known about between-group differences. HIV-positive populations are aging and have high rates of substance use compared to non-infected peers, while substance use among older adults has increased and is associated with unprotected intercourse. Among a sample of 239 HIV-positive bisexual and gay men aged 50 and older, bisexual men were more likely to report cigarette, cocaine, crack, and heroin use compared with gay men. However, bisexual men were less likely to use crystal meth, club drugs, poppers (nitrate inhalers), and erectile dysfunction (ED) medi...
HIV/AIDS in Older Women: Unique Challenges, Unmet Needs.
Authors: Durvasula R Abstract As persons living with HIV/AIDS live longer, both the prevalence and incidence of HIV infection in older women is expected to increase, and this review presents a model and review of the extant literature on older women with HIV/AIDS in the United States. Older women are rarely addressed in the discourse about HIV risk and prevention, and their concerns are often missed by risk-reduction programs that typically target men and younger adults. Societal biases around aging can compound factors such as stigma and disclosure for older women. Primary care providers are often not recommending routine HIV testing to older women, or addressing the impact of age-related physiological changes on risk and sexual health. Many older women may be starting new relatio...
Africa: Martin O'malley Announces Intention to Resign As Global Fund's Inspector General
[GFO]His departure in early 2015 should give the Board enough time to recruit a replacement (Source: AllAfrica News: HIV-Aids and STDs)
Watch a Science Cop Take on Donald Trump
The Ebola outbreak that is causing such fear and suffering in Africa is a very real and very deadly thing. But the fact is that the nature of the Ebola virus is such that it stands a very low chance of ever causing a pandemic like AIDS or H1N1. That hasn?t stopped America?s great foghorn?Donald Trump?and others like him from spreading all kinds of misinformation about the disease, warning people that patients should not be brought to the U.S. and that flights from West Africa should be stopped, otherwise we face an American epidemic. But Trump and his ilk are committing a science crime?the crime of misinformation. Here?s the truth, from TIME&#8217;s Jeffrey Kluger. &nbsp; &nbsp; (Source: TIME.com: Top Science and Health Stories)
Artist Elana Lamger was inspired by her grandmother to redefine and style disability accessories
The project is the work of artist Elana Langer and photographer Hanna Agar, both from New York, and aims to challenge the stigma around hearing aids and walkers. (Source: the Mail online | Health)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
An Epidemic: Top 10 Outbreaks In U.S. History
Throughout the years, epidemics and plagues have shaken up societies and cultures around the world. The latest outbreak that Americans seem to be concerned about is the Ebola epidemic occurring in the African countries of Guinea, Liberia, Sierra Leone and Nigeria.  With experts and doctors saying that the outbreak has the potential to become a full-blown pandemic that will become increasingly more difficult to control, the general public is scared. While the Centers for Disease Control and Prevention continuously keep an eye on public health and any immediate health dangers, the American public still worries about how much control we really have over such outbreaks. Recently, two Americans were brought back to the U.S. to be treated at Emory Hospital in Atlanta after contracting the Ebola...
Antiretrovirals Before Pregnancy Appear to Be SafeAntiretrovirals Before Pregnancy Appear to Be Safe
Pre-exposure prophylaxis is safe during the periconceptual period for women who become pregnant, new research from the Partners PrEP Study shows. Medscape Medical News (Source: Medscape Today Headlines)
Africa: Communiqué De Presse
[UNAIDS]Melbourne -Dix organisations ont reçu le Prix Ruban Rouge pour leur leadership exceptionnel en matière de sida (Source: AllAfrica News: HIV-Aids and STDs)
Africa: UNAIDS and Partners Launch Initiative to Improve HIV Diagnostics
[UNAIDS]Melbourne/Geneva -Partners will advocate for increased funding and price reductions, strengthen efforts to ensure highest quality diagnostic services and forge partnerships to close diagnostic access gaps. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: UNAIDS Report Shows That 19 Million of the 35 Million People Living With HIV Today Do Not Know That They Have the Virus
[UNAIDS]Geneva -In sub-Saharan Africa, nearly 90% of people who know their HIV-positive status are on treatment-ending the AIDS epidemic by 2030 will require smart scale-up to close the gap (Source: AllAfrica News: Health and Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Africa: Declining Investment Could Slow Research and Rollout of New HIV Prevention Options
[UNAIDS]Melbourne, Australia -Report shows prevention R&D funding falls 4% due to public sector research budget reductions in US, Europe (Source: AllAfrica News: HIV-Aids and STDs)
Africa: Ten Organizations Receive Red Ribbon Award for Outstanding Community Leadership On Aids
[UNAIDS]Ten exceptional community-based organizations have won the 2014 Red Ribbon Award for their inspiring work in reducing the impact of the AIDS epidemic. They were presented with the prestigious prize in a special session at the 20th International AIDS Conference (AIDS 2014) in Melbourne, Australia. The Red Ribbon Award is the world's leading award for innovative and outstanding community work in the response to the AIDS epidemic. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: Global Leaders Commit to Ending the Aids Epidemic in Cities By 2030
[UNAIDS]Melbourne -In a meeting initiated by UNAIDS and hosted by the city of Melbourne, Australia, global leaders agreed that cities and local leadership are the key to ending the AIDS epidemic by 2030. The inaugural Cities for Social Transformation meeting took place on the sidelines of the 20th International AIDS Conference. Mayors and representatives of 18 cities, governors, senior members of parliament, health ministers, a Head of State and senior health professionals attended the event. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: Kaiser/UNAIDS Study Finds Dip in Donor Government Commitments for Aids in 2013
[UNAIDS]Melbourne, Australia -Actual disbursements in 2013 increased 8% as some funds from earlier years were spent (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: HIV/Aids Kills More Than Ebola, Says NACA DG
[This Day]Notwithstanding the global threat posed by the infectious Ebola Virus Disease (EVD), the Director General of the National Agency for the Control of (AIDS) (NACA), Prof. John Idoko, has said that the virus does not kill as much as HIV/AIDS. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Zimbabwe: Kicking HIV Out of Hibernation
[The Herald]A follower of one of the many Pentecostal churches in Zimbabwe hops and runs as he makes his way to the podium. It is a cool Sunday afternoon in March 2014 and he stands in front of over 30 000 other followers to announce that he has been cured of HIV and has his latest results to prove it. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: Stakeholders Worry Over Sustainability of HIV/Aids Post 2015
[Daily Trust]As the deadline for the achievement of the MDGs goal draws closer, stakeholders in the HIV/AIDS sector are concerned over the sustainability of the project so as not relegate on the successes gained in eliminating the virus by 2030. (Source: AllAfrica News: HIV-Aids and STDs)
Rwanda: Scientists to Put Lab Services At Centre of HIV/Aids Fight
[New Times]As the world comes together to try and tackle HIV/Aids, an initiative by the African Society for Laboratory Medicine (ASLM) and UNAIDS is rooting for laboratory services to be placed at the forefront of the fight. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: 'We Need Commitment to Eliminate HIV/Aids By 2030'
[Leadership]Abuja -The director general, National Agency for the Control of AIDS (NACA), Prof John Idoko and stakeholders in the sector have solicited for support and commitment from relevant bodies to sustain the country's set goal of eliminating the HIV/AIDS virus by 2030. (Source: AllAfrica News: HIV-Aids and STDs)
Angola: Inls Reiterates Importance of Breastfeeding
[ANGOP]Luanda -The National Institute for Combat AIDS (INLS) has reiterated the importance of breastfeeding in the first six months of the child's life, due to its many essential nutrients for the health of minors. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Antiretroviral treatment adherence as a mediating factor between psychosocial variables and HIV viral load
Psychosocial factors may directly impact HIV health measures such as viral load (VL), whether or not patients are taking antiretroviral treatment (ART) consistently. Structural equation modeling plus Baron and Kenny's (1986) four-step approach were used to test a mediated model predicting VL among 246 HIV-infected adults who were on ART. Exogenous variables were social support, barriers to adherence, and stress. Moderators were alcohol use, marijuana use, and neurocognitive impairment. A small positive association between marijuana use and ART adherence approached significance. (Source: Journal of the Association of Nurses in AIDS Care)
Novel Antiretroviral Drugs and Renal Function Monitoring of HIV Patients.
Authors: Maggi P, Montinaro V, Mussini C, Di Biagio A, Bellagamba R, Bonfanti P, Calza L, Cherubini C, Corsi P, Gargiulo M, Montella F, Rusconi S Abstract Chronic kidney disease is a major comorbidity in patients affected by HIV infection. In addition, the introduction of new antiretroviral agents that interact with creatinine transporters is raising some concerns. In this review we analyze the currently available data about three new antiretroviral drugs and one new pharmacokinetic enhancer. Three of them (rilpivirine, cobicistat, dolutegravir) have shown some interactions with renal function, while tenofovir alafenamide fumarate reduces the plasmatic concentration of the parent drug. The future use of tenofovir alafenamide seems to be encouraging in order to reduce the renal inte...
Pre-Exposure Prophylaxis for the Primary Prevention of HIV in At-Risk Women: Empowerment and Equity Revisited.
Authors: Kofman A, Adashi EY Abstract Women continue to bear a disproportionate burden of the HIV epidemic's impact. The last three years have witnessed the explosive emergence of pre-exposure prophylaxis as a viable, woman-initiated, and woman-controlled candidate for the primary prevention of HIV in women. These developments have proven particularly significant for at-risk women in environments where negotiation of safe sex is difficult. In this review, we trace the recent evolution of the pre-exposure prophylaxis vision for women, delineate the clinical trials that made it all possible, and discuss ongoing efforts required for its full actualization. PMID: 25102335 [PubMed - as supplied by publisher] (Source: AIDS Reviews)
Role of RANKL-RANK/Osteoprotegerin Pathway in Cardiovascular and Bone Disease Associated with HIV Infection.
Authors: Kelesidis T, Currier JS, Yang OO, Brown TT Abstract Patients with HIV?1 infection often develop multiple complications and comorbidities, including osteoporosis and atherosclerosis. The receptor activator of nuclear factor kappa-B/receptor activator of nuclear factor kappa-B ligand/osteoprotegerin axis has been identified as a possible common link between osteoporosis and vascular diseases. Since the discovery of this axis, much has been learned about its role in controlling skeletal biology and less about its role in the context of vascular biology. However, the exact role of the receptor activator of nuclear factor kappa-B ligand/osteoprotegerin axis in HIV infection is not completely understood. In this review we examine the mechanisms by which inflammation and immune...
Monkey-adapted HIV-1 highlights in vivo significance of restriction factors.
Authors: Kirmaier A, Johnson WE Abstract HIV-1 was isolated 31 years ago, yet models for studying HIV-1 pathogenesis in vivo are still lacking. Recent experiments using an HIV-1 strain engineered to replicate in macaques recapitulate several important features of human AIDS, and provide insight into the genetics of cross-species transmission and emergence of pathogenic retroviruses. PMID: 25127418 [PubMed - as supplied by publisher] (Source: Trends in Microbiology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
2 First Ladies Share Tales of Budding Partnership and Life in the Spotlight
Michelle Obama and Laura Bush sponsored a forum for the spouses of visiting African leaders and shared the stage with a rapport born of the shared opportunities and burdens of their role. (Source: NYT)
HIV Rates Lower in Women With Circumcised PartnersHIV Rates Lower in Women With Circumcised Partners
The first real-world evidence supports the benefit of male circumcision. Medscape Medical News (Source: Medscape Medical News Headlines)
Bush Urges Renewed Fight Against Deadly Diseases in Africa
Former President George W. Bush, speaking at a health forum in Washington, spoke of ?the beginning of the end of AIDS.? (Source: NYT)
Ghana: Peer Educators Train On HIV/Aids
[Ghana Govt.]A forty (40) peer educators have undergone a 3-day training programme to provide Community Based Comprehensive Sexual Education, (CBCSE) on HIV/AIDS prevention and management to adolescents and young people in the Bawku municipality. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Eating any fish once a week aids future brain health regardless of omega-3 content
Fish eaters had more grey matter in areas responsible for memory, say Pittsburgh researchers. But the fish must be grilled or baked - and not fried. (Source: the Mail online | Health)
South Africa: Children Blame Defaulting for Mother's Death
[Health-e]Thabang Malekutu, 18, is raising three younger siblings following his mother's recent death due to AIDS-related illnesses after she defaulted on treatment. (Source: AllAfrica News: HIV-Aids and STDs)
?I Pray That They Accept Me Without Scolding:? Experiences with Disengagement and Re-Engagement in HIV Care and Treatment Services in Tanzania
AIDS Patient Care and STDs , Vol. 0, No. 0. (Source: AIDS Patient Care and STDs)
Age at Antiretroviral Therapy Initiation Predicts Immune Recovery, Death, and Loss to Follow-Up Among HIV-Infected Adults in Urban Zambia
AIDS Research and Human Retroviruses , Vol. 0, No. 0. (Source: AIDS Research and Human Retroviruses)
Regular Book review: Children Caring for Parents with HIV and AIDS: Global Issues and Policy Responses
(Source: Childhood)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Inpatient pharmacological sleep aid utilization is common at a tertiary medical center
CONCLUSIONSDespite increasing evidence of risks such as delirium or falls, pharmacological sleep aid use in general wards remains common, even in elderly patients. Medication administration time is frequently suboptimal. Many previously sleep medication?naïve patients leave the hospital with a sleep aid prescription. Further research is needed to understand the factors that contribute to the high rate of sleep medication use in hospitalized patients. Journal of Hospital Medicine 2014. © 2014 Society of Hospital Medicine (Source: Journal of Hospital Medicine)
Mortality trends show more people with HIV dying from non AIDS cancers.
Authors: Abstract An investigation into mortality trends in people with HIV has found a fall in the percentage of deaths attributable to AIDS related causes but an increase in deaths from non AIDS cancers. PMID: 25095930 [PubMed - in process] (Source: Nursing Standard)
Knee posture during gait and global functioning post-stroke: a theoretical ICF framework using current measures in stroke rehabilitation.
Conclusions: AKP restricts functioning and participation. Implications for Rehabilitation Identification of abnormal knee posture in gait can indicate potential assessment and treatment priorities, e.g. knee flexor strength is a major determinant of functioning in patients with abnormal knee posture and should be assessed. The identification of an abnormal knee posture post-stroke seems relevant for planning patient's long-term needs (e.g. amount of caregiver support). The interpretation of functional measures based on the ICF framework can enhance clinical-reasoning in rehabilitation post-stroke. PMID: 25095902 [PubMed - as supplied by publisher] (Source: Disability and Rehabilitation)
Breaking Open Public Places: UNFPA Launches Coolibah - 21 July 2014
MELBOURNE, Australia &ndash; At the International AIDS Conference 2014 today, UNFPA, the United Nations Population Fund, launched a youth networking zone called the coolibah, where, throughout the week, it will host a range of activities for and with young people, including a series of luncheons with leaders in the field of HIV and AIDS. (Source: UNFPA News)
UNFPA engages young people in the fight against HIV - 21 July 2014
MELBOURNE, Australia &ndash; Every hour, about 80 young people are newly infected with HIV, according to the recently released Gap Report by UNAIDS. The participation and leadership of young people will therefore be critical in bringing the global HIV epidemic to an end. Today, at the 20th International AIDS Conference, UNFPA launched a youth networking zone called the &lsquo;coolibah&rsquo;, where young people will be able to speak with leaders in the field of HIV and AIDS. (Source: UNFPA News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Africa: USAID Official's 5 Take-Aways From Aids 2014
[State Department]This blog post by David Stanton was first posted on the U.S. Agency for International Development's Impact blog. Stanton is the director of USAID's Office of HIV/AIDS. (Source: AllAfrica News: HIV-Aids and STDs)
Predicting the Probability of Experiencing Clinically Significant Drug?Drug Interactions Involving Boceprevir-Containing Hepatitis C Therapy Among Patients Coinfected with Hepatitis C and HIV
AIDS Patient Care and STDs , Vol. 0, No. 0. (Source: AIDS Patient Care and STDs)
South Africa: Treatment Action Campaign in a Tavern
[GroundUp]People should view taverns as part of the community, where young people can meet to enjoy themselves, and not as enemies, community activists told a meeting at the weekend of the Kuyasa branch of the Treatment Action Campaign. (Source: AllAfrica News: HIV-Aids and STDs)
People with HIV May Be at Lower Risk for Multiple Sclerosis
Constant immune system suppression may be the reason why, researchers say Source: HealthDay Related MedlinePlus Pages: HIV/AIDS, Multiple Sclerosis (Source: MedlinePlus Health News)
A Qualitative Study of Underutilization of the AIDS Drug Assistance Program
In our previous work, we demonstrated underutilization of the AIDS Drug Assistance Program (ADAP) at an HIV clinic in Alabama. In order to understand barriers and facilitators to utilization of ADAP, we conducted focus groups of ADAP enrollees. Focus groups were stratified by sex, race, and historical medication possession ratio as a measure of program utilization. We grouped factors according to the social-ecological model. We found that multiple levels of influence, including patient and clinic-related factors, influenced utilization of antiretroviral medications. (Source: Journal of the Association of Nurses in AIDS Care)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Violence Experiences Among HIV-Infected Women and Perceptions of Male Perpetrators' Roles: A Concurrent Mixed Method Study
This study was designed to (a) explore the personal, cognitive, and psychosocial factors of intimate partner violence among women with HIV; (b) explore the perceptions of male perpetrators' roles in contributing to violence; and (c) determine the implications for methodological and data source triangulation. A concurrent Mixed Method study design was used, including 30 African American male and female participants. Quantitative data were analyzed using descriptive statistics. (Source: Journal of the Association of Nurses in AIDS Care)
Nigeria: Nigeria Wakes Up to Its Aids Threat
[IPS]Tope Tayo's marriage broke up 11 years ago after she tested positive for HIV. Her angry and embarrassed husband took away their only child. Three months later, when the one year old boy tested positive, the husband dumped him with Tayo and absconded. (Source: AllAfrica News: Health and Medicine)
Simplification to rilpivirine/emtricitabine/tenofovir disoproxil fumarate from ritonavir-boosted protease inhibitor antiretroviral therapy in a randomized trial of HIV-1 RNA-suppressed participants: Erratum
No abstract available (Source: AIDS)
Tanzania: HIV/Aids Fund to Start Next Year
[Daily News]TANZANIA Commission for AIDS (TACAIDS) Executive Chairperson, Dr Fatma Mrisho, said the much awaited Tanzania HIV/AIDS Fund will be operational by the next financial year. (Source: AllAfrica News: HIV-Aids and STDs)
Eritrea: Southern Region - Endeavors Being Made As Regards Control of HIV/Aids and TB Witness More Impact
[Shabait]Mendefera -The Health Ministry's branch in the Southern region has indicated that the endeavors being made as regards control of HIV/AIDS and TB have witnessed more impact equitably. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Genome editing eradicates HIV-1 [Medical Sciences]
AIDS remains incurable due to the permanent integration of HIV-1 into the host genome, imparting risk of viral reactivation even after antiretroviral therapy. New strategies are needed to ablate the viral genome from latently infected cells, because current methods are too inefficient and prone to adverse off-target effects. To eliminate... (Source: Proceedings of the National Academy of Sciences)
Power analysis and sample size estimation for sequence-based association studies
Motivation: Statistical methods have been developed to test for complex trait rare variant (RV) associations, in which variants are aggregated across a region, which is typically a gene. Power analysis and sample size estimation for sequence-based RV association studies are challenging because of the necessity to realistically model the underlying allelic architecture of complex diseases within a suitable analytical framework to assess the performance of a variety of RV association methods in an unbiased manner. Summary: We developed SEQPower, a software package to perform statistical power analysis for sequence-based association data under a variety of genetic variant and disease phenotype models. It aids epidemiologists in determining the best study design, sample size and statistical te...
Levels of circulating myeloid subpopulations and of heme oxygenase-1 do not predict CD4+ T cell recovery after the initiation of antiretroviral therapy for HIV disease
The level (or frequency) of circulating monocyte subpopulations such as classical (CD14hiCD16-) and non-classical (CD14dimCD16+) monocytes varies during the course of HIV disease progression and antiretroviral therapy (ART). We hypothesized that such variation and/or differences in the degree to which these cells expressed the immunoregulatory enzyme, heme oxygenase-1 (HO-1), would be associated with CD4+ T cell recovery after the initiation of ART. This hypothesis was tested in a cross-sectional study of four groups of HIV-infected subjects, including those who were seronegative, untreated virologic controllers [detectable viral load (VL) of 10,000 copies/mL], and ART-mediated virologic controllers [VL < 75 copies/mL]. A longitudinal analysis of ART-treated subjects was also performed alo...
The Association Between Depressive Symptoms, Anger, and Perceived Support Resources Among Underserved Older HIV Positive Black/African American Adults
AIDS Patient Care and STDs , Vol. 0, No. 0. (Source: AIDS Patient Care and STDs)
Breaking Open Public Places: UNFPA Launches Coolibah - 21 July 2014
MELBOURNE, Australia &ndash; At the International AIDS Conference 2014 today, UNFPA, the United Nations Population Fund, launched a youth networking zone called the coolibah, where, throughout the week, it will host a range of activities for and with young people, including a series of luncheons with leaders in the field of HIV and AIDS. (Source: UNFPA News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
UNFPA engages young people in the fight against HIV - 21 July 2014
MELBOURNE, Australia &ndash; Every hour, about 80 young people are newly infected with HIV, according to the recently released Gap Report by UNAIDS. The participation and leadership of young people will therefore be critical in bringing the global HIV epidemic to an end. Today, at the 20th International AIDS Conference, UNFPA launched a youth networking zone called the &lsquo;coolibah&rsquo;, where young people will be able to speak with leaders in the field of HIV and AIDS. (Source: UNFPA News)
Nigeria: Aids Conference Delegates Seek Asylum in Australia
[Guardian]SOME 25 delegates to an international AIDS conference held in Melbourne last month fear returning home and will seek asylum in Australia, refugee and welfare agencies said Monday. (Source: AllAfrica News: Health and Medicine)
Eritrea: Eritrea's Continued Progress in Combating HIV/Aids
[Fahamu]Eritrea's remarkable success in combating HIV/AIDS is founded upon a multisectoral approach that involves the targeting of harmful societal behaviors and traditions like banning child marriage and female genital cutting (Source: AllAfrica News: HIV-Aids and STDs)
Senegal: Children, the Biggest Losers in Fight Against Aids
[IPS]Dakar -Children living with HIV in Senegal suffer because of the taboo associated with this disease in a country which is, however, praised for its fight against the pandemic. (Source: AllAfrica News: Health and Medicine)
South Africa: Aids Conference Returns to Durban in 2016
[Health-e]The International AIDS Society announced in Melbourne last week that the biennial AIDS conference will return to Durban in 2016. But this time, the circumstances in the country are significantly different than 2000. Last year, only around 7 600 babies were infected with HIV by their mothers, in comparison to 56 000 babies in 2003. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
South Africa: Opinion - It's Time We Caught Up to HIV Science
[Health-e]The country's first openly HIV-positive Mr Gay South Africa finalist Charles Jacobs asks, HIV science has changed but have we? The latest court case against the South African National Defense Force (SANDF) may be a sign that we haven't. (Source: AllAfrica News: HIV-Aids and STDs)
Uganda: Male Circumcision Lowers HIV Risk for Women-Study Shows
[Independent]A man being prepared for circumcision.A campaign to promote male circumcision to prevent AIDS infection also indirectly benefits women by reducing their risk of contracting the HIV virus, according to a study presented on July 25 at the world AIDS forum. (Source: AllAfrica News: HIV-Aids and STDs)
Malawi: Chiradzulu DAC Hails World Vision for HIV and Aids Support
[Malawi News Agency]Chiradzulu -The District Aids Coordinator for Chiradzulu, Christopher Nawata has commended Non Governmental Organizations (NGOs) for playing a pivotal role in implementing Prevention of Mother to Child Transmission of HIV initiative in the district. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: Financing Trends and Making Smarter Investments in the HIV Response
[Key Correspondents]During a high-level political session at the 20th International AIDS Conference, UNAIDS executive director Michel Sidibé has called for a new set of treatment targets by 2030. (Source: AllAfrica News: HIV-Aids and STDs)
Tanzania: HIV/Aids Infections Can Be Stopped - UNAIDS
[Daily News]NEW HIV/AIDS infections can be stopped in the country if there is more dialogue and people involvement, UNAIDS Country Coordinator, Dr Patrick Brenny said. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Nigeria Wakes Up to its AIDS Threat
Nigeria accounts for one third of all new infections among children in the 20 worst hit countries in sub-Saharan Africa. Credit: Sam Olukoya/IPSBy Sam OlukoyaLAGOS, Nigeria, Aug 4 2014 (IPS) Tope Tayo?s marriage broke up 11 years ago after she tested positive for HIV. Her angry and embarrassed husband took away their only child. Three months later, when the one year old boy tested positive, the husband dumped him with Tayo and absconded.  ?He abandoned us as if we had committed a crime but I told him HIV is not a crime,? Tayo told IPS. She was jobless and the husband paid no maintenance. ?I walked the streets crying, I was living on charity,? Tayo recalls. The runaway man who abandons his HIV positive wife and children is a common feature in Nigeria, says Rosemary Hua, coordina...
Commentary: Antiretroviral treatment for pregnant and breastfeeding women ? the shifting paradigm: Erratum
No abstract available (Source: AIDS)
Risk of Cancer Among HIV-Infected IndividualsRisk of Cancer Among HIV-Infected Individuals
How much of an impact to immune deficiency and smoking have on cancer risk in HIV+ individuals? AIDS (Source: Medscape Today Headlines)
New idea for hearing improvement in patients with hearing aids under background noise
(Neural Regeneration Research) Patients with implanted artificial cochlea often complain that they cannot recognize speech well in natural environments, especially if background of noise is present. Researchers think that a poor ability to localize sound in a complex auditory environment is responsible for the weak speech perception observed under these conditions. (Source: EurekAlert! - Medicine and Health)
Therapeutic drug monitoring of voriconazole: a case report of multiple drug interactions in a patient with an increased CYP2C19 activity
Conclusion: The integration of drug-drug interactions and pharmacogenetics data is crucial to interpret drug concentrations correctly, thus preventing suboptimal exposure to voriconazole. (Source: AIDS Research and Therapy)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Influence of providers and nurses on completion of non-targeted HIV screening in an urgent care setting
Conclusions: Visit provider and triage nurse were strongly associated with acceptance of testing, which may reflect variable opinions of HIV screening in this setting by clinical staff. Among patients accepting screening, visit provider remained strongly associated with completion of testing. Despite longstanding recommendations for non-targeted HIV screening, further changes to improve the testing and results process, as well as provider education and buy-in, are needed to improve screening rates. (Source: AIDS Research and Therapy)
Representation of Health Conditions on Facebook: Content Analysis and Evaluation of User Engagement
Conclusions: This research represents the first attempts to comprehensively describe publicly available health content and user engagement with health conditions on Facebook pages. Public health interventions using Facebook will need to be designed to ensure relevant information is easy to find and with an understanding that stigma associated with some health conditions may limit the users? engagement with Facebook pages. This line of research merits further investigation as Facebook and other SNS continue to evolve over the coming years. (Source: Journal of Medical Internet Research)
Teaching NeuroImages: Partial Brown-Sequard syndrome: A rare presentation of CMV myelitis
A 53-year-old man with AIDS presented with left leg weakness and right leg numbness. Examination was significant for left lower extremity weakness in a pyramidal pattern (4/5), left knee and ankle hyperreflexia, left Babinski sign, and decreased pain and temperature sensation over right lower extremity extending up the right torso up to T5 dermatome. Vibration and proprioception were normal. Thoracic spine MRI showed hyperintensity in the left hemicord (figure, A and B). CSF analysis showed mild protein elevation with lymphocytic pleocytosis, and positive cytomegalovirus (CMV) PCR, consistent with CMV myelitis. Treatment with gancylcovir1 and foscarnet2 resulted in gradual improvement in the patient's symptoms and examination. (Source: Neurology)
Data Are Key In Care For Patients With HIV/AIDS [Letters]
(Source: Health Affairs)
Cohort Profile: Seek and Treat for the Optimal Prevention of HIV/AIDS in British Columbia (STOP HIV/AIDS BC)
The Seek and Treat for Optimal Prevention of HIV/AIDS (STOP HIV/AIDS) cohort is a census of all identified HIV-positive individuals in the province of British Columbia. It was formed through the linkage of nine provincial treatment, surveillance and administrative databases. This open cohort allows for bidirectional analyses from 1996 onward and is refreshed annually. Extensive data collection for cohort members includes demographic information, detailed clinical and laboratory data, complete prescription drug use including antiretroviral agents, and information on health service utilization encompassing inpatient and outpatient care, addictions treatment and palliative care. This cohort provides an unprecedented opportunity to evaluate, over an extended time period, patterns and determina...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Constrictive Pericarditis Requiring Pericardiectomy at Groote Schuur Hospital in Cape Town, South Africa: Causes and Peri-operative Outcomes in the HIV Era (1990 ? 2012)
This study is the largest on the subject emanating from Africa in the HIV/AIDS era. It highlights the importance of early referral for pericardiectomy in constrictive pericarditis and the safety of surgery in those infected with HIV/AIDS. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Cognitive deficits associated with combined HIV gp120 expression and chronic methamphetamine exposure in mice
Methamphetamine abuse is common among individuals infected by human immunodeficiency virus (HIV). Neurocognitive outcomes tend to be worse in methamphetamine users with HIV. However, it is unclear whether discrete cognitive domains are susceptible to impairment after combined HIV infection and methamphetamine abuse. The expression of HIV/gp120 protein induces neuropathology in mice similar to HIV-induced pathology in humans. We investigated the separate and combined effects of methamphetamine exposure and gp120 expression on cognitive function in transgenic (gp120-tg) and control mice. (Source: European Neuropsychopharmacology)
Constrictive pericarditis requiring pericardiectomy at Groote Schuur Hospital, Cape Town, South Africa: Causes and perioperative outcomes in the HIV era (1990-2012)
The causes of constrictive pericarditis and predictors of perioperative outcome after pericardiectomy have not been clearly elucidated, especially in Africa, where the disease characteristics differ from those in developed countries. Furthermore, the effect of human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) on pericardial constriction and outcomes after surgery is unknown. We investigated the causes of constrictive pericarditis, outcomes after pericardiectomy, and predictors of mortality in Cape Town, South Africa, during a 22-year period of high HIV/AIDS prevalence. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Structural and community-level interventions for increasing condom use to prevent the transmission of HIV and other sexually transmitted infections.
CONCLUSIONS: There is no clear evidence that structural interventions at the community level to increase condom use prevent the transmission of HIV and other STIs. However, this conclusion should be interpreted with caution since our results have wide confidence intervals and the results for prevalence may be affected by attrition bias. In addition, it was not possible to find RCTs in which extended changes to policies were conducted and the results only apply to general populations in developing nations, particularly to Sub-Saharan Africa, a region which in turn is widely diverse. PMID: 25072817 [PubMed - in process] (Source: Herpes)
Clinical relevance of the plasma load of cytomegalovirus in patients infected with HIV?a survival analysis
ABSTRACT To investigate whether asymptomatic cytomegalovirus (CMV) viraemia impact the course of human immunodeficiency virus (HIV) infection, this study evaluated the effect of CMV replication on progression of newly?diagnosed HIV infected individuals towards AIDS events and death. In a 3?year prospective study on co?infected patients, clinical, immunological, and virological tests were performed in a national reference hospital quarterly. CMV viraemia was quantified by RoboGene® HCMV DNA Quantification Kit (Analytik Jena, Germany), on ABI Prism® 7000 Sequence Detection System (Applied Biosystems, USA). One hundred and five patients were enrolled with a balanced sex distribution and a median age of 30.7?years. Median CD4+ cell count at enrollment was 164/mm3 and median HIV RNA 4...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Africa: Children Living With Aids, That's Where It Hurts the Most
[Key Correspondents]When HIV was discovered in the early 1980s, one shock came after another. First, it is a virus for which there was no cure. Second, it has serious health implications and, before the arrival of antiretroviral therapy, would likely lead to mortality. Finally, most shocking perhaps was the discovery that it was trans-generational, which means babies being born with the virus. (Source: AllAfrica News: HIV-Aids and STDs)
Breaking Open Public Places: UNFPA Launches Coolibah - 21 July 2014
MELBOURNE, Australia &ndash; At the International AIDS Conference 2014 today, UNFPA, the United Nations Population Fund, launched a youth networking zone called the coolibah, where, throughout the week, it will host a range of activities for and with young people, including a series of luncheons with leaders in the field of HIV and AIDS. (Source: UNFPA News)
UNFPA engages young people in the fight against HIV - 21 July 2014
MELBOURNE, Australia &ndash; Every hour, about 80 young people are newly infected with HIV, according to the recently released Gap Report by UNAIDS. The participation and leadership of young people will therefore be critical in bringing the global HIV epidemic to an end. Today, at the 20th International AIDS Conference, UNFPA launched a youth networking zone called the &lsquo;coolibah&rsquo;, where young people will be able to speak with leaders in the field of HIV and AIDS. (Source: UNFPA News)
The provision of aids and adaptations, risk assessments, and incident reporting and recording procedures in relation to injury prevention for adults with intellectual disabilities: cohort study - Finlayson J, Jackson A, Mantry D, Morrison J, Cooper SA.
BACKGROUND: Adults with intellectual disabilities (IDs) experience a higher incidence of injury, compared with the general population. The aim of this study was to investigate the provision of aids and adaptations, residential service providers' individual... (Source: SafetyLit: All (Unduplicated))
Girls Just Wanna Have Fun: a process evaluation of a female youth-driven physical activity-based life skills program
Conclusions: Overall, this process evaluation represents an important step in responding to calls for increased evaluation in community-based programs and aids in understanding the process in which positive youth development programs can be effectively implemented. (Source: Epidemiologic Perspectives and Innovations)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Increase in condom use and decline in prevalence of sexually transmitted infections among high-risk men who have sex with men and transgender persons in Maharashtra, India: Avahan, the India AIDS Initiative
Conclusion: The current evaluation provides evidence for successful scale up and coverage of target population by Avahan interventions in Maharashtra. The assessment findings showed improved accessibility to condoms and reduced risk behaviours with male sexual partners. Syphilis prevalence declined; however HIV prevalence did not change and is still a major concern. Continued strengthening of core programmatic strategies are needed to effectively improve condom use with all partner types and to help bring sustained reductions in HIV risk in HR-MSM/TG and its onward transmission. (Source: BMC Public Health - Latest articles)
Adherence to antiretroviral therapy in adolescents living with HIV: systematic review and meta-analysis
Conclusion:Review of published literature from Africa and Asia indicate more than 70% of HIV-positive AYA populations receiving ART are adherent to therapy and lower rates of adherence were shown in Europe and North America at 50?60%. The global discrepancy is probably multifactorial reflecting differences between focused and generalised epidemics, access to healthcare and funding. (Source: AIDS)
Engagement-in-Care During the First 5 Years After HIV Diagnosis: Data from a Cohort of Newly HIV-Diagnosed Individuals in a Large US City
AIDS Patient Care and STDs , Vol. 0, No. 0. (Source: AIDS Patient Care and STDs)
[Editorial] Chronic kidney disease: refining diagnosis and management
From 1990 to 2010, deaths from chronic kidney disease (CKD) rose by about 82% worldwide?the third largest increase among the top 25 causes of death after HIV/AIDS (396%) and diabetes (93%). In England, about £1·45 billion was spent on caring for people with CKD in 2009?10, just 1·3% of National Health Service spending, and a substantial proportion of this cost was devoted to renal replacement therapy in the small proportion of patients with kidney failure. In July, the UK's National Institute of Health and Care Excellence (NICE) updated its clinical guideline on CKD, aiming to ensure consistent identification of CKD and thereby improve management. (Source: LANCET)
[Comment] Offline: Ending the AIDS epidemic
There are some articles journal editors will wish they hadn't brought to public attention. But there will also be papers they are immensely grateful to have published. One such Lancet paper is Julio Montaner's truly landmark 2006 viewpoint entitled, rather modestly now looking back, ?The case for expanding access to highly active antiretroviral therapy [HAART] to curb the growth of the HIV epidemic?. The paper began by charting, since its inception in 1996, the rise and impact of HAART. Montaner and his team went on to hypothesise that, ?A prevention-centred approach would therefore argue that treating 100% of HIV-infected individuals at once could greatly reduce HIV transmission. (Source: LANCET)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
TLRs: Linking Inflammation and Breast cancer.
Authors: Bhatelia K, Singh K, Singh R Abstract Breast cancer is one of the leading causes of mortality in the females. Intensive efforts have been made to understand the molecular mechanisms of pathogenesis of breast cancer. The physiological conditions that lead to tumorigenesis including breast cancer is not well understood. Toll like receptors (TLRs), are essential component of innate immune system that protects the host against bacterial and viral infection. The emerging evidences suggest that TLRs are activated through pathogen associated molecular patterns (PAMPs) as well as endogenous molecules, which lead to the activation of inflammatory pathways. This leads to increased levels of several pro-inflammatory cytokines and chemokines mounting inflammation. Several evidences su...
Large-Scale HIV Test-and-Treat Strategy ViableLarge-Scale HIV Test-and-Treat Strategy Viable
A large-scale trial in which residents are offered HIV testing and treatment is feasible at a population level. Medscape Medical News (Source: Medscape Today Headlines)
A Randomized Controlled Trial of the Efficacy of a Stigma Reduction Intervention for HIV-Infected Women in the Deep South
AIDS Patient Care and STDs , Vol. 0, No. 0. (Source: AIDS Patient Care and STDs)
Hormonal Contraceptives Don't Increase HIV Risk, Study FindsHormonal Contraceptives Don't Increase HIV Risk, Study Finds
Contraceptives Medscape Medical News (Source: Medscape Today Headlines)
'HIV drugs boost' SA life expectancy
Life expectancy in South Africa has increased dramatically over the last decade mainly thanks to life-saving Aids drugs, a government report says. (Source: BBC News | Health | UK Edition)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
HIV drugs 'boost SA life expectancy'
Life expectancy in South Africa has increased dramatically over the last decade mainly thanks to life-saving Aids drugs, a government report says. (Source: BBC News | Health | UK Edition)
Africa: View On Migration - Anti-HIV Measures That Cross Borders
[SciDev.Net]Earlier this month, UNAIDS published its annual Gap report, drawing together global data on HIV/AIDS alongside information and analysis about the 'people being left behind' in the fight against the disease. (Source: AllAfrica News: HIV-Aids and STDs)
This won't be AIDS-free generation
He was just 18 years old when he got the news. It was the summer before his senior year in high school. (Source: CNN.com - Health)
Kenya: Tribunal Tackles Aids Discrimination
[Capital FM]Nairobi -Since its establishment in 2009, The HIV and AIDS Tribunal has dealt with 60 cases where people were discriminated for being HIV positive in Kenya. (Source: AllAfrica News: HIV-Aids and STDs)
Breaking Open Public Places: UNFPA Launches Coolibah - 21 July 2014
MELBOURNE, Australia &ndash; At the International AIDS Conference 2014 today, UNFPA, the United Nations Population Fund, launched a youth networking zone called the coolibah, where, throughout the week, it will host a range of activities for and with young people, including a series of luncheons with leaders in the field of HIV and AIDS. (Source: UNFPA News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
UNFPA engages young people in the fight against HIV - 21 July 2014
MELBOURNE, Australia &ndash; Every hour, about 80 young people are newly infected with HIV, according to the recently released Gap Report by UNAIDS. The participation and leadership of young people will therefore be critical in bringing the global HIV epidemic to an end. Today, at the 20th International AIDS Conference, UNFPA launched a youth networking zone called the &lsquo;coolibah&rsquo;, where young people will be able to speak with leaders in the field of HIV and AIDS. (Source: UNFPA News)
Nigeria: Nigeria and the HIV Burden
[Independent]Even as global attention focused more on the tragic shutting down of Malaysian Airline MH17 allegedly by Ukrainian rebels , the World AIDS Conference which held in Melbourne, Australia between 21-25 July was another reflective milestone on a malaise that have threatened human posterity. (Source: AllAfrica News: HIV-Aids and STDs)
Disappearance of Renal Stones in an HIV-1-Infected Patient After Reduction of Atazanavir Dose
AIDS Research and Human Retroviruses , Vol. 0, No. 0. (Source: AIDS Research and Human Retroviruses)
Computer?assisted reading intervention with a phonics approach for children using cochlear implants or hearing aids
The present study examined computer?assisted reading intervention with a phonics approach for deaf and hard of hearing (DHH) children in Sweden using cochlear implants or hearing aids, or a combination of both. The study included 48 children, 5, 6 and 7 years of age. Sixteen children with normal hearing (NH) served as a reference group. The first purpose of the study was to compare NH and DHH children's reading ability at pre and post?intervention. The second purpose was to investigate effects of the intervention. Cognitive and demographic factors were analyzed in relation to reading improvement. Results showed no statistically significant difference for reading ability at the group level, although NH children showed overall higher reading scores at both test points. Age comparisons r...
The RAB5?GEF Function o f RIN1 Regulates Multiple Steps During Listeria monocytogenes Infection
Abstract Listeria monocytogenes is a food?borne pathogenic bacterium that invades intestinal epithelial cells through a phagocytic pathway that relies on activation of host cell RAB5 GTPases. L. monocytogenes must subsequently inhibit RAB5, however, in order to escape lysosome?mediated destruction. Relatively little is known about upstream RAB5 regulators during L. monocytogenes entry and phagosome escape processes in epithelial cells. Here we identify RIN1, a RAS effector and RAB5?directed GEF, as a host cell factor in L. monocytogenes infection. RIN1 is rapidly engaged following L. monocytogenes infection and is required for efficient invasion of intestinal epithelial cells. RIN1?mediated RAB5 activation later facilitates the fusion of phagosomes with lysosomes, promoting clearan...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Impact of community-based interventions on HIV knowledge, attitudes, and transmission
This paper evaluates the impact of community based delivery if interventions on HIV knowledge, attitudes, and transmission. Findings suggest that community based interventions to increase HIV awareness and risk reduction interventions are effective in improving knowledge scores for HIV/AIDS, protected sexual encounters, increased condom use and decreasing frequency of sexual intercourse. Image: Community based delivery of ART for HIV. (Source: Epidemiologic Perspectives and Innovations)
Regional and national guideline recommendations for digital ano-rectal examination as a means for anal cancer screening in HIV positive men who have sex with men: a systematic review
Conclusions: Few HIV guidelines discuss or recommend DARE as a means of anal cancer screening. Studies of the efficacy, acceptability and cost-effectiveness of DARE are needed to assess its role in anal cancer screening. (Source: Epidemiologic Perspectives and Innovations)
[In Depth] Cure setbacks force HIV researchers to reset sights
Remission is seen as a more realistic goal. Author: Jon Cohen (Source: Science: Current Issue)
The Effects of Parental Loss on the Psychosocial Wellbeing of AIDS-Orphaned Children Living in AIDS-Impacted Communities: Does Gender Matter?
Authors: Nabunya P, Ssewamala FM PMID: 25067869 [PubMed - as supplied by publisher] (Source: Children and Youth Services Review)
In the Routine HIV Testing Era, Primary Care Physicians in Community Health Centers Remain Unaware of HIV Testing Recommendations
Conclusion: With the new 2013 US Preventive Services Task Force recommendations to support routine HIV testing, it is critical to address ongoing physician HIV testing barriers to mitigate the HIV epidemic. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Association between Dog Guardianship and HIV Clinical Outcomes
Despite numerous potential health outcomes of dog guardianship, their value has not been examined in the HIV-positive population. The study objective was to examine the relationship between dog guardianship and HIV clinical outcomes (antiretroviral adherence [&ge;95% versus &lt;95%], HIV viral load [&ge;48 versus &lt;48 copies/mL], and CD4 count) among HIV-positive individuals. The authors conducted a secondary analysis of baseline data of 370 HIV-positive men on antiretroviral regimen enrolled in the Duo Project. Generalized estimating equations were used for inferential regression analyses, while controlling for the focal dog guardianship variable and nonfocal covariates. Current dog guardianship was reported in 28.7% of participants. Dog guardianship may be associated with higher CD4 (c...
Religion and HIV/AIDS Stigma in Puerto Rico: A Cultural Challenge for Training Future Physicians
In this study, we documented the association of religion with HIV/AIDS stigma in a sample of medical students in Puerto Rico. Findings suggest that importance placed on religion, and participation in religious activities, is associated with HIV/AIDS stigma for this population. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
Rhodococcus equi Pericarditis in a Patient Living with HIV/AIDS
We report a case of a 48-year-old male patient with newly diagnosed HIV/AIDS presenting with recurrent R equi bacteremia, pericardial effusion, and pericardial cyst. The infection was treated with drainage of the pericardial effusion and cyst and 2 weeks of intravenous vancomycin and 6 months of oral azithromycin and levofloxacin. Discussion: Rhodococcus equi causes pericarditis and pericardial effusion. It can be effectively treated with debridement, drainage, and a prolonged course of antibiotics. In vitro antibiotic susceptibility should be checked as resistance to antibiotics can develop, especially if drainage is inadequate. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
AIDS-Related Lymphoma: Resolution with Antiretroviral Therapy Alone
We present a case of a female patient with HIV (CD4 count of 576 cells/mm3) diagnosed with a stage III-B non-Hodgkin lymphoma in 2009 while off HAART. She was subsequently started on HAART, leading to full resolution of her lymphoma without any chemotherapeutic intervention. She was last seen in the clinic in December 2013 without any evidence of recurrence of her lymphoma. To our knowledge, this is the first case report of a stage III-B non-Hodgkin lymphoma in an HIV-infected patient, which resolved with only HAART. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
HIV-Associated Thromboembolic Phenomenon due to Protein C Deficiency
We report a case of a 12-year-old girl with facial palsy due to middle cerebral artery infarct because of HIV infection and associated protein C deficiency. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
The Effect of Relaxation Interventions on Cortisol Levels in HIV-Seropositive Women
Conclusions: Results suggest that specific relaxation techniques may be partially responsible for cortisol decreases associated with relaxation and CBSM. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
CD4 Counts in Laboratory Monitoring of HIV Disease--Experience from Western India
Conclusion: The cutoff values of CD4 counts for HIV disease may need to be revised for India. Regular CD4 count estimation is a must for monitoring disease progression in people living with HIV/AIDS. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
Pain, Sleep Disturbances, and Functional Limitations in People Living with HIV/AIDS-Associated Distal Sensory Peripheral Neuropathy
Conclusions: The data collected suggest that PLWHA-DSPN report moderate-to-severe pain and significant sleep disturbances and exhibit limited ambulation distances. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
Group Problem-Solving Therapy for Postnatal Depression among HIV-Positive and HIV-Negative Mothers in Zimbabwe
Postnatal depression (PND) is a major problem in low- and middle-income countries (LMICs). A total of 210 postpartum mothers attending primary care urban clinics were screened for PND at 6 weeks postpartum using the Edinburgh Postnatal Depression Scale (EPDS) and Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition; DSM-IV) criteria for major depression. The HIV prevalence was 14.8%. Of the 210 enrolled postpartum mothers, 64 (33%) met DSM IV criteria for depression. Using trained peer counselors, mothers with PND (n = 58) were randomly assigned to either group problem-solving therapy (PST, n = 30) or amitriptyline (n = 28). Of the 58 mothers with PND, 49 (85%) completed 6 weeks of group PST (n = 27) or pharmacotherapy (n = 22). At baseline, the mean EPDS score for partici...
HIV Provider-Patient Communication Regarding Cardiovascular Risk: Results from the 2010 AIDS Treatment for Life International Survey
Conclusion: We found that HIV clinicians worldwide are not sufficiently addressing CVD risk factors with their patients. Expanded training and education for HIV clinicians should include effective approaches to the mitigation of CV risk factors. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
The Effect of Depressive Symptoms and CD4 Count on Adherence to Highly Active Antiretroviral Therapy in Sub-Saharan Africa
Conclusions: These results indicate that mental health and clinical parameters are significant factors in determining patients&rsquo; adherence to their HAART, which need to be more aggressively addressed as a critical component of care and treatment support. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
Ritonavir-Boosted Lopinavir as Maintenance Monotherapy in HIV-Infected Patients Who Achieved Viral Suppression during a Second-Line Protease Inhibitor-Based Regimen: A Pilot Randomized Trial (BIDI-MONO)
Eligibility criteria were (1) having previously failed first-line nonnucleoside reverse transcriptase inhibitor&ndash;based regimens and (2) having achieved virologic suppression &gt;6 months while receiving a protease inhibitor (PI)-based regimen as second-line treatment. Eligible participants were randomized to receive either (1) ritonavir-boosted lopinavir (LPV/r) monotherapy (n = 29) or (2) LPV/r with optimized background regimens (OBRs; n = 31). Median duration of viral suppression before randomization was 45 months. At week 48, viral suppression during LPV/r monotherapy was 86.2% and did not differ from the suppression achieved with LPV/r with OBRs (87.1%, P = 1.000). However, persistent viremia during LPV/r monotherapy tended to be higher than during LPV/r with OBRs (10.3% versus 3....
Evaluation of an HIV Adherence Counseling Program in La Romana, Dominican Republic
Research has demonstrated that adherence to antiretroviral therapy (ART) results in lower rates of morbidity and mortality associated with HIV infection, yet adherence remains a challenge in resource-limited settings like the Dominican Republic. Cl&iacute;nica de Familia La Romana addressed this problem with an education-based adherence program for adult patients new to ART, and this retrospective cohort study aimed to evaluate the impact of this intervention. Appointment adherence and biological markers were assessed in cases and controls through 12 months. A total of 101 participants were included, with 61 controls and 40 cases. The baseline CD4 count was 162 and 157 cells/mm3 in controls and cases, respectively. Cases showed a 15-fold increase in CD4 count compared with a 2.5-fold incre...
Long-Term Outcome of Second-Line Antiretroviral Therapy in Resource-Limited Settings
There is limited information on efficacy and durability of second-line antiretroviral therapy (2NL) beyond 12 months in resource-limited settings. A total of 73 patients were enrolled into a prospective 2NL observational cohort in Nigeria. Second-line antiretroviral therapy consisted of lopinavir/ritonavir plus nucleoside reverse transcriptase inhibitors. Time on 2NL ranged from 15 to 31 months. Genotypes were retrospectively done and not available to guide second-line regimen choice. At enrollment, median CD4 count was 121 cells/mm3, and median time on first-line antiretroviral therapy (1SL) was 24 months. At 6 to 9 months on 2NL, 72.6% (intention to treat [ITT]) and 88.3% (on treatment [OT]) had an undetectable viral load (UDVL). At 12 months, 65.8% (ITT) and 90.57% (OT) had UDVL. At &gt...
"Notify Your Partners--It's the Law": HIV Providers and Mandatory Disclosure
This study compared provider attitudes and practices in relation to counseling clients about mandatory disclosure in North Carolina and Alabama, the 2 states with similar HIV epidemiology but different laws for HIV control. Personal interviews were conducted with 20 providers in each state (n = 40). The results were analyzed in a qualitative, cross-comparison method to identify patterns of convergence or difference. Providers in both states believed that clients often failed to notify sexual partners and were secretive if questioned about disclosure. Differences in counseling styles and procedures for each state were noteworthy. Compared to Alabama, North Carolina had harsher penalties for nondisclosure, stricter and more standardized procedures for counseling, and providers expressed grea...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Law and Pediatric HIV Testing: Realizing the Right to Health in Kenya
Realization of the right to health occurs along a continuum including national ratification of international treaties such as the Convention on the Rights of the Child, passage of domestic laws and policies that may specify modes of implementation and enforcement such as Kenya&rsquo;s Constitution and HIV and AIDS Prevention and Control Act, and actual implementation of domestic laws and policies such as through the regulation and delivery of health services. The stages heuristic theoretical framework describes the public policy continuum as consisting of marked stages: agenda setting, policy formulation, policy implementation, and evaluation. This case study illustrates the continuum in Kenya with regard to pediatric HIV testing. Kenya has made progress applying law, policy, and science t...
Differential glycosylation of envelope gp120 is associated with differential recognition of HIV-1 by virus-specific antibodies and cell infection
Conclusion: Our data support the hypothesis that the glycosylation machinery of different cells shapes gp120 glycosylation and, consequently, impacts envelope recognition by specific antibodies as well as the interaction of HIV-1 gp120 with cellular receptors. These findings underscore the importance of selection of appropriately glycosylated HIV-1 envelope as a vaccine antigen. (Source: AIDS Research and Therapy)
AIDSinfo HIV/AIDS Awareness Day Widget Now Available
AIDSinfo is pleased to announce the release of our HIV/AIDS Awareness Day widget! Add the widget to your website or blog to display the logos for the national HIV/AIDS awareness days. The logos will link to the AIDSinfo HIV/AIDS awareness day pages. The widget also provides links to the infoSIDA HIV/AIDS awareness day pages.&nbsp; Along with our HIV/AIDS awareness day widget, we also have a widget for our news feed. Add this widget to your website to display the latest HIV/AIDS treatment, prevention, and research news. Instructions for adding the widgets to your website can be found on the AIDSinfo widget page.&nbsp; Questions about our widgets? Please send an e-mail to ContactUs@aidsinfo.nih.gov. (Source: AIDSinfo At-a-Glance: Offering Information on HIV/AIDS Treatment, Prevention, and...
News from NIAID
July 24, 2014: Powerful HIV Antibodies May Require Assist from Second Antibody to Develop July 21, 2014: At AIDS 2014, Dr. Anthony S. Fauci Discusses Key Challenges in HIV Scientific Discovery: Cure, Vaccine&nbsp; July 21, 2014: NIH-Supported Scientists Demonstrate Very Early Formation of SIV Reservoir July 19, 2014: HIV Cure Research: Where We Are, Where We Are Headed (Source: AIDSinfo At-a-Glance: Offering Information on HIV/AIDS Treatment, Prevention, and Research, A Service of the U.S. Department of Health and Human Services (DHHS))
Development and preliminary user testing of the DCIDA (Dynamic computer interactive decision application) for 'nudging' patients towards high quality decisions
Conclusion: Preliminary results suggest that DCIDA has potential to improve the quality of patient decision-making. Next steps include larger studies to test individual components of DCIDA and feasibility testing with patients making real decisions. (Source: BMC Medical Informatics and Decision Making - Latest articles)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
HIV and Child Mental Health: A Case-Control Study in Rwanda
CONCLUSIONS: The mental health of HIV-affected children requires policy and programmatic responses comparable to HIV-positive children. (Source: PEDIATRICS)
Cost effectiveness of a web-based decision aid for parents deciding about MMR vaccination: a three-arm cluster randomised controlled trial in primary care.
CONCLUSION: The decision aid has a high chance of being cost effective, regardless of the value placed on obtaining additional vaccinations. It also appears to offer an efficient means of decision support for parents. PMID: 25071062 [PubMed - in process] (Source: The British Journal of General Practice)
Direct Anterior versus Miniposterior THA With the Same Advanced Perioperative Protocols: Surprising Early Clinical Results.
CONCLUSIONS: There was no systematic advantage of direct anterior THA versus miniposterior THA. Contrary to conventional belief and somewhat surprising were the fewer minor wound problems in the direct anterior group and the higher proportion of patients free of gait aids at 2 weeks and back to driving and working at 8 weeks in the miniposterior group. Factors other than surgical approach, perhaps including attentive pain management, patient selection, surgical volume and experience, careful preoperative templating, and rapid rehabilitation protocols, may be more important in terms of influencing early recovery after THA. LEVEL OF EVIDENCE: Level III, therapeutic study. See Instructions for Authors for a complete description of levels of evidence. PMID: 25082624 [PubMed - as supp...
Increased costs of HIV care associated with aging in an HIV?infected population
ConclusionsThe aging of the HIV?infected population in care is leading to increased HIV care costs. Health care planners and funding agencies need to be aware of the impact of this important shift in HIV demographics on the overall costs of HIV care. (Source: HIV Medicine)
[Osteogenesis imperfecta].
Authors: Salzmann M, Krohn C, Berger N Abstract BACKGROUND: Osteogenesis imperfecta (OI) is the most common genetic disease of bone and is characterized by fragile bones and growth disorders of varying severity. Most cases of OI are inherited autosomal dominant and caused by a mutation in the collagen type I gene. DIAGNOSTICS: Indications for OI are bone fragility, stunted growth, scoliosis, skull deformities, blue sclera, loss of hearing, dentinogenesis imperfecta and increased laxity of ligaments and skin. In most cases it is possible to make a clinical diagnosis but a skin biopsy or genetic testing can be useful; however, negative results for these tests do not exclude OI. THERAPY: Therapy must be carried out in a multidisciplinary team and includes conservative (e.g. ph...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Information and decision?making needs among people with mental disorders: a systematic review of the literature
ConclusionsThis review reveals that patients with schizophrenia and depression show extensive information and decision?making needs. The identified needs can initially inform the design of PtDAs for schizophrenia and depression. However, there is an urgent need to investigate information and decision?making needs among patients with other mental disorders. (Source: Health Expectations)
The Pediatrician's Role in Community Advocacy for Childhood Obesity Prevention.
Authors: Wacker J, Bosley E, Bolling C Abstract As childhood obesity rates continue to rise, increasing numbers of pediatric providers are advocating for healthier environments outside clinic walls. Understanding the role of the pediatrician in childhood obesity advocacy within the context of the socioecological model helps ground engagement efforts. Once a project is underway, applying evidence-based obesity clinical care principles to community-focused work creates a template for engaging with partners and developing an intervention. In addition to content expertise, providers can guide community partners through the project development process, particularly in setting realistic goals and determining relevant, attainable health outcomes. Capitalizing on existing advocacy resource...
[Effect of socioeconomic status on mortality in urban areas: a systematic critical review].
Authors: Salgado-Barreira A, Estany-Gestal A, Figueiras A Abstract Socioeconomic inequalities cause more disease and death than most risk factors, especially in cities. This systematic review of the scientific evidence included articles in English, Spanish, Portuguese, and Italian and excluded studies with low levels of evidence and those that did not analyze associations between mortality and socioeconomic status in urban settings. Articles were selected by two independent reviewers, and data extraction used evidence tables. A total of 1,509 records were obtained, and 24 were included. All the studies showed higher mortality rates in poorer areas. Six studies showed an association with cardiovascular diseases, four with lung diseases, and three with AIDS, infectious and parasitic ...
Evaluation of hydrocephalus and other cerebrospinal fluid disorders with MRI: An update
Abstract MRI is not only beneficial in the diagnosis of cerebrospinal fluid (CSF)-related diseases, but also aids in planning the management and post-surgery follow-up of the patients. With recent advances in MRI systems, there are many newly developed sequences and techniques that rapidly enable evaluation of CSF-related disorders with greater accuracy. For a better assessment of this group of disorders, radiologists should follow the developments closely and should be able to apply them when necessary. In this pictorial review, the role of MRI in the evaluation of hydrocephalus, CSF diversion techniques, and other CSF disorders is illustrated. Teaching Points ? The 3D-SPACE seems to be most efficient technique for evaluation of hydro...
The provision of aids and adaptations, risk assessments, and incident reporting and recording procedures in relation to injury prevention for adults with intellectual disabilities: cohort study
ConclusionMore work is needed to better understand, and more fully incorporate, best practice injury prevention measures into routine support planning for adults with IDs within a positive risk?taking and risk reduction framework. (Source: Journal of Intellectual Disability Research)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Africa: New Tools Released to Help Countries Put Women and Girls At the Center of Their Concept Notes
[GFO]A failure to integrate gender-specific interventions has resulted in concept notes being returned to some countries (Source: AllAfrica News: HIV-Aids and STDs)
Lessons Learned from the Conduct of a Multisite Cluster Randomized Practical Trial of Decision Aids in Rural and Suburban Primary Care Practices
Reports on participant recruitment for a community-based primary care practice study that included rural clinics. Discusses lessons learned related to timing and location of recruitment and impact of recruitment methods on the intervention implementation. Also describes how the study was designed to minimize disruption for the participating clinical sites. -- (Source: Rural publications via the Rural Assistance Center)
Wnt/?-catenin aids in regulating the proliferation of hepG2 cells mediated by thy-1.
Authors: Cheng BQ, Jiang Y, Zhu Q, Lin WG Abstract Cancer stem cells have been found to play important roles in carcinoma. Although thy-1 has been identified as a potential stem cell marker of liver cancer, whether the Wnt/?-catenin signaling pathway plays an important role in regulating hepatocarcinoma proliferation and apoptosis mediated by thy-1 remains unknown. Our results showed that high thy-1 expression caused hepG2 cells transfected with a pReceiver-M29/thy-1 eukaryotic expression vector to exhibit obvious heteromorphism, featuring double or multiple nuclei and weaker apoptosis. A high expression of ?-catenin, as a critical signaling protein of Wnt/?-catenin, and its downstream transcription factor, cyclinD1, were detected in transfected hepG2 cells. We also used aspirin...
Localization of Productively Infected Cells in the Spleen and Peyer's Patches of Rhesus Macaques During Acute Infection with SIVmac239?nef-Enhanced Green Fluorescent Protein
AIDS Research and Human Retroviruses Aug 2014, Vol. 30, No. 8: 738-739. (Source: AIDS Research and Human Retroviruses)
Interleukin-23 Promotes Interferon-? Responsiveness in Hepatitis C Virus/HIV-Coinfected Patients
AIDS Research and Human Retroviruses Aug 2014, Vol. 30, No. 8: 775-782. (Source: AIDS Research and Human Retroviruses)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Short Communication: Prospective Comparison of Qualitative Versus Quantitative Polymerase Chain Reaction for Monitoring Virologic Treatment Failure in HIV-Infected Patients
AIDS Research and Human Retroviruses Aug 2014, Vol. 30, No. 8: 827-829. (Source: AIDS Research and Human Retroviruses)
Short Communication: Effects of Omega-3 Fatty Acids on Triglycerides and High-Density Lipoprotein Subprofiles in HIV-Infected Persons with Hypertriglyceridemia
AIDS Research and Human Retroviruses Aug 2014, Vol. 30, No. 8: 800-805. (Source: AIDS Research and Human Retroviruses)
Short Communication: Serum-Based Assay Accurately Detects Single Nucleotide Polymorphisms of IL28B and SOCS3 in HIV/Hepatitis C Virus-Coinfected Subjects
AIDS Research and Human Retroviruses Aug 2014, Vol. 30, No. 8: 792-795. (Source: AIDS Research and Human Retroviruses)
Short Communication: East Meets West: A Description of HIV-1 Drug Resistance Mutation Patterns of Patients Failing First Line Therapy in PEPFAR Clinics from Uganda and Nigeria
AIDS Research and Human Retroviruses Aug 2014, Vol. 30, No. 8: 796-799. (Source: AIDS Research and Human Retroviruses)
Short Communication: Molecular Epidemiology of HIV Type 1 Infection in Kazakhstan: CRF02_AG Prevalence Is Increasing in the Southeastern Provinces
AIDS Research and Human Retroviruses Aug 2014, Vol. 30, No. 8: 769-774. (Source: AIDS Research and Human Retroviruses)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Breaking Open Public Places: UNFPA Launches Coolibah - 21 July 2014
MELBOURNE, Australia &ndash; At the International AIDS Conference 2014 today, UNFPA, the United Nations Population Fund, launched a youth networking zone called the coolibah, where, throughout the week, it will host a range of activities for and with young people, including a series of luncheons with leaders in the field of HIV and AIDS. (Source: UNFPA News)
UNFPA engages young people in the fight against HIV - 21 July 2014
MELBOURNE, Australia &ndash; Every hour, about 80 young people are newly infected with HIV, according to the recently released Gap Report by UNAIDS. The participation and leadership of young people will therefore be critical in bringing the global HIV epidemic to an end. Today, at the 20th International AIDS Conference, UNFPA launched a youth networking zone called the &lsquo;coolibah&rsquo;, where young people will be able to speak with leaders in the field of HIV and AIDS. (Source: UNFPA News)
South Africa: Cosatu Condemns SANDF's Discrimination Against People With HIV
[COSATU]The Congress of South African Trade Unions is shocked that the SA National Defence Force has cancelled the contracts of two women recruits because they tested HIV-positive. They have challenged the decision and taken the SANDF to court. The judge's verdict is awaited. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: Women Affairs Ministry to Partner USAID, NACA On GBV, HIV/Aids
[Nigerian Govt]The Federal Ministry of Women Affairs and Social Development is to partner with the United States Agency for International Development (USAID) and the National Agency for Control of AIDS (NACA) in the fight against the growing cases of Gender - Based Violence (GBV) and HIV/AIDS in the country. (Source: AllAfrica News: HIV-Aids and STDs)
Hearing Aids Market Analysis by Product (Behind-The-Ear Aids,...
Market Size - $4,369.3 mn in 2013, Market Growth ? CAGR of 3.2%, Market Trends ? Rapidly growing adoption rates of 100% digital hearing aid technology. View full report with TOC -...(PRWeb July 30, 2014)Read the full story at http://www.prweb.com/releases/Hearing_Aids_Market_Size/Industry_Trends_Analysis/prweb12058370.htm (Source: PRWeb: Medical Pharmaceuticals)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Repeat Antenatal HIV Testing in the Third TrimesterRepeat Antenatal HIV Testing in the Third Trimester
Should a repeat HIV test be performed in the third-trimester of pregnancy? HIV Medicine (Source: Medscape Today Headlines)
Africa: The 'Sex-On-Site' Venues Tour - Queer Melbourne's Erotic Otherworld
[Daily Maverick]Picture going on a tour of venues where people go specifically to have sex. Usually with strangers. In all kinds of unusual ways. But, it seems, whatever they're doing, they're awfully hygienic about it. Seem like an unusual way to spend a morning? REBECCA HODES actually did it. The tour, that is. Strictly business. (Source: AllAfrica News: HIV-Aids and STDs)
Mozambique: First Lady Begins Working Visit to Zambezia
[AIM]Quelimane, Mozambique -Mozambican First Lady Maria da Luz Guebuza on Monday arrived in Quelimane, the provincial capital of Zambezia, at the beginning of a two day working visit. (Source: AllAfrica News: HIV-Aids and STDs)
Functional assessment of multivessel coronary artery disease: ischemia-guided percutaneous coronary intervention
Invasive evaluation and treatment of coronary artery disease (CAD) has traditionally been based upon coronary angiography to determine the need for and the success of revascularization. However, coronary angiography augmented with fractional flow reserve (FFR) creates a paradigm shift, providing a more complete functional assessment of coronary lesions. Measuring FFR to identify ischemic lesions and guide revascularization results in fewer adverse outcomes, including persistent angina, myocardial infarction, and mortality. An ischemic lesion identified by FFR is more likely to lead to adverse events when compared with an angiographically similar lesion with nonischemic FFR when both are treated medically. Although the mechanism explaining this is unclear, it is likely multifactorial, inclu...
Elizabeth Glaser Pediatric AIDS Foundation partners with Riders for Health in Malawi
(Elizabeth Glaser Pediatric AIDS Foundation) Today the Elizabeth Glaser Pediatric AIDS Foundation and Riders for Health announced a new partnership that will expedite the delivery of laboratory samples and HIV-related test results to health facilities in two districts of the Northern and Central Zones of Malawi. (Source: EurekAlert! - Medicine and Health)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Bonga Update
Habari zenu? (How are you?) This past week in Bonga, we?ve been busier than ever. We started teaching at the government schools ¬¬? Bonga Secondary School and Bonga Primary School. We finished our curriculum at Hayatul Islamic Secondary School. Not only did we meet with each form for the last time, we also started a Peer Education club. This club is supposed to continue teaching fellow students and their local community about HIV and AIDS. We prepared them to take on this task during their orientation that consisted of making a constitution, voting for officers and doing practice teachings. When we return from break, we will watch their final teachings and hold a mini graduation ceremony. The week at Hayatul ended with our first testing day ¬? we brought a mobile testing unit to t...
The Latest from Haraa
In conclusion, there was absolutely no shortage of good times here in Haraa this week. Slowly slowly we&#8217;re becoming less mzungu, and Haraa is coming to feel more and more like home. We couldn&#8217;t feel more grateful for the chance to share with and learn from this community! Hannah B., Kelsey, Olivia, Elizabeth, and Rashidi The post The Latest from Haraa appeared first on Support For International Change. (Source: Support for International Change : HIV AIDS)
More from Team Himiti!
The Himiti team had a busy week of teaching and prepping for our village-wide testing day. We finally got to teach in our primary school, which included students and even their teachers. We thought it was important that the teachers knew about HIV/AIDS so that they can continue to educate their students after we leave. We also had the opportunity to teach in a variety of village social groups and even some random places where large groups of people were gathered and willing to listen to us. Thursday was spent entirely dedicated to prepping for our test day, the day in which any member of the village will have the opportunity to find out their HIV status through tests provided by SIC. We split up into three groups and headed to each of the sub-villages where we handed out flyers, put up pos...
Global burden, distribution, and interventions for infectious diseases of poverty
This paper aims to review the disease burden, distribution, existing interventions, and coverage for the prevention and control of IDoPs (including NTDs, malaria, TB, and HIV/AIDS), and is followed by a series of papers evaluating the effectiveness of community delivered interventions for the prevention and control of each IDoP. Image: Community based delivery of Interventions for IDoP. (Source: BioMed Central)
HIV-1 Infection Activates the NLRP3 Inflammasome [Microbiology]
We report here that HIV-1 infection in human monocytes efficiently induced IL-1? expression and inflammasome activation. Toll-like receptor 8 (TLR8) was required for inducing pro-IL-1? expression, whereas the NLRP3 inflammasome was required for IL-1? maturation and release. Furthermore, the lysosomal protease cathepsin B and HIV-1 induced production of reactive oxygen species were critical for HIV-induced inflammasome activation and IL-1? production. HIV-1 entry, reverse transcription, and integration were all required for both pro-IL-1? expression and inflammasome activation. Finally, we show that HIV-1-derived RNA was sufficient to induce both pro-IL-1? expression and inflammasome activation. We conclude that HIV-1 infection induced the expression of pro-IL-1? via TLR8-mediated me...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Antigay Laws Already Having a Negative Effect on HealthAntigay Laws Already Having a Negative Effect on Health
The criminalization of same-sex behavior around the world is having a negative effect on health in high-risk HIV groups, including men who have sex with men. Medscape Medical News (Source: Medscape Medical News Headlines)
Kenya: HIV Funding Worries in Kenya
[IRIN]Kisumu/Nairobi -The US President's Emergency Plan for Aids Relief (PEPFAR), the biggest funder of HIV programmes in Kenya, is set to significantly scale down its funding, a move activists and government officials believe could negatively affect the country's fight against the disease. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: Ebola Virus Deadlier Than HIV/Aids - Experts
[Leadership]Ebola virus is the most difficult health challenge confronting the third world countries and is deadlier than HIV/AIDs,medical experts have declared. (Source: AllAfrica News: HIV-Aids and STDs)
Zimbabwe: Teenagers Produce HIV,Aids Film
[The Herald]Three teenagers Simbarashe Moyana, Josh Chikosha and Frankson Chikosha have embarked on an HIV and AIDS awareness campaign through a film titled "The Seed of Life" that is set to premiere next month. In an interview Moyana who is one of the producers of the film said different issues affecting the society inspired them to have the production. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: HIV/Aids - Ogun Falls Below National Prevalence Average
[Independent]Abeokuta -The recent National HIV/AIDS Reproductive and Health Survey (NARHS) report has identified Ogun State as being below the national average of HIV infections with a prevalence rate of 0.6 per cent. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Breaking Open Public Places: UNFPA Launches Coolibah - 21 July 2014
MELBOURNE, Australia &ndash; At the International AIDS Conference 2014 today, UNFPA, the United Nations Population Fund, launched a youth networking zone called the coolibah, where, throughout the week, it will host a range of activities for and with young people, including a series of luncheons with leaders in the field of HIV and AIDS. (Source: UNFPA News)
UNFPA engages young people in the fight against HIV - 21 July 2014
MELBOURNE, Australia &ndash; Every hour, about 80 young people are newly infected with HIV, according to the recently released Gap Report by UNAIDS. The participation and leadership of young people will therefore be critical in bringing the global HIV epidemic to an end. Today, at the 20th International AIDS Conference, UNFPA launched a youth networking zone called the &lsquo;coolibah&rsquo;, where young people will be able to speak with leaders in the field of HIV and AIDS. (Source: UNFPA News)
Coreceptor Usage, Diversity, and Divergence in Drug-Naive and Drug-Exposed Individuals from Malawi, Infected with HIV-1 Subtype C for More Than 20 Years
AIDS Research and Human Retroviruses , Vol. 0, No. 0. (Source: AIDS Research and Human Retroviruses)
Erratum
Conclusion: The integrative review allowed to point important questions to be addressed in preventive actions by the health professional, including the nurse, to create a space that works with risk conditioning factors in adolescents for mental health aggravation.?Identificar los factores de riesgo asociados a los problemas de salud mental en adolescentes. Método: Se realizó una revisión integradora de artículos publicados entre los años 2007 y 2013 en cuatro bases de datos. Para la búsqueda de artículos, se utilizaron los descriptores: Salud Mental y Adolescencia, conforme a las bases DeCS/MeSH. Resultados: Se encontraron publicaciones en diferentes revistas, en distintos campos de conocimiento, siendo más frecuentes las investigaciones cuantitativas. Los problemas en salud ment...
Reliability and Reproducibility of Several Methods of Arthroscopic Assessment of Femoral Tunnel Position During Anterior Cruciate Ligament Reconstruction
To assess interobserver and intraobserver agreement of estimating anterior cruciate ligament (ACL) femoral tunnel positioning arthroscopically using circular and linear (noncircular) estimation methods and to determine whether overlay template visual aids improve agreement. (Source: Arthroscopy)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
New Tuberculosis Regimen Works Faster, Costs LessNew Tuberculosis Regimen Works Faster, Costs Less
The new once-daily oral regimen known as PaMZ appears to work on both drug-sensitive and multidrug-resistant tuberculosis. Medscape Medical News (Source: Medscape Medical News Headlines)
Digital Reading System Assists Vision Impaired to Read Graphs
People who are blind can now read more than just words, such as graphs and graphics, following the development of an affordable digital reading system by Curtin University researchers. (Source: Disabled World)
Nearly half of Albuquerque health care workers do not have a bachelor?s degree, study says
Nearly half the health care jobs in the Albuquerque metropolitan area are held by pre-baccalaureate workers, or those without a bachelor?s degree, and those workers are the fastest-growing segment of the health care industry, according to a study by the Brookings Institution. Those workers are concentrated in 10 jobs, including nurses, home health aids, medical and dental assistants and emergency medical technicians and paramedics, and many have seen large increases in earnings since 2000, Brookings? (Source: bizjournals.com Health Care:Hospitals headlines)
A Polyvalent Clade B Virus-Like Particle HIV Vaccine Combined with Partially Protective Oral Preexposure Prophylaxis Prevents Simian?Human Immunodeficiency Virus Infection in Macaques and Primes for Virus-Amplified Immunity
AIDS Research and Human Retroviruses , Vol. 0, No. 0. (Source: AIDS Research and Human Retroviruses)
Uptake and Repeat Use of Postexposure Prophylaxis in a Community-Based Clinic in Los Angeles, California
AIDS Research and Human Retroviruses , Vol. 0, No. 0. (Source: AIDS Research and Human Retroviruses)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Prevalence and Virologic Consequences of Transmitted HIV-1 Drug Resistance in Uganda
AIDS Research and Human Retroviruses , Vol. 0, No. 0. (Source: AIDS Research and Human Retroviruses)
Technology: Disrupting Disaster Response since 1881
By Dom Tolli, Preparedness, Health and Safety Services Back in 1881, the American Red Cross used the telegraph for the first time to transmit disaster information during a forest fire in Michigan. I have hunch that someone at the time probably thought the telegraph was fad and that only ?the young people? were into it. Little did anyone know it would launch the Red Cross -and the nation &#8211; onto a path of using technology to help during disasters. Since 1881, the Red Cross has made a paradigm shift in how it distributes information to the public in times of crisis. Instead of distributing millions of brochures and flyers with emergency we now issue millions of mobile alerts and our apps have more than 100 million mobile views. Now, mobile technology is bringing the White House, th...
Study: iPad-based HIV prevention game increased adolescents? knowledge of the disease
Children who played iPad-based HIV prevention game PlayForward: Elm City Stories knew more about HIV risk than those that played other video games, according to an oral abstract on a randomized control trial of 198 adolescents presented at the AIDS conference this week. The mean age of children in this trial was 13. The NIH-funded video game was developed [&#8230;] (Source: mobihealthnews)
Africa: Heightened HIV Risk for People With Disabilities
[IRIN]Melbourne -Inaccessible health services for people with disabilities (PWD), combined with social stigma and violence, contribute to high HIV risk - a gap that must be filled if the disabled are not to remain disproportionately vulnerable to HIV/AIDS, say health experts and activists. (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: BD & PEPFAR Launch Multi-Year Labs for Life Initiative in Kenya
[U.S. Embassy Nairobi]Nairobi, Kenya -Program Focuses on Strengthening Healthcare Systems, Starting with Accreditation for 10 Laboratories (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Breaking Open Public Places: UNFPA Launches Coolibah - 21 July 2014
MELBOURNE, Australia &ndash; At the International AIDS Conference 2014 today, UNFPA, the United Nations Population Fund, launched a youth networking zone called the coolibah, where, throughout the week, it will host a range of activities for and with young people, including a series of luncheons with leaders in the field of HIV and AIDS. (Source: UNFPA News)
UNFPA engages young people in the fight against HIV - 21 July 2014
MELBOURNE, Australia &ndash; Every hour, about 80 young people are newly infected with HIV, according to the recently released Gap Report by UNAIDS. The participation and leadership of young people will therefore be critical in bringing the global HIV epidemic to an end. Today, at the 20th International AIDS Conference, UNFPA launched a youth networking zone called the &lsquo;coolibah&rsquo;, where young people will be able to speak with leaders in the field of HIV and AIDS. (Source: UNFPA News)
Zimbabwe: HIV Status Does Not Affect Eligibility for Pension
[The Herald]Can an HIV positive person qualify for a pension? This was a questioned that was asked by one correspondent who claims to have contributed to the NSSA national pension scheme from 1994 to 2007. (Source: AllAfrica News: HIV-Aids and STDs)
Southern Africa: HIV and Aids Threat to SADC Development
[The Herald]AS leaders from the region gather for the 34th Sadc Summit in Victoria Falls next month, they must seriously reflect on the devastating effect of the HIV and Aids pandemic that is threatening to decimate entire populations. (Source: AllAfrica News: HIV-Aids and STDs)
Rwanda: Circumcision Yields Results as Ebola Threatens
[New Times]A new study by the University of Illinois indicates that circumcised men do not only lower chances of getting HIV by 60% but also are less likely to engage in unprotected sex. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Nigeria: HIV Infection No Longer On the Rise in Nigeria - Idoko
[Leadership]The fear of HIV/AIDS, that debilitating disease, remains the beginning of wisdom for everyone. A recent report that HIV infection was on the increase in the country was not well received. But in this interview with WINIFRED OGBEBO, the director-general, National Agency for the Control of AIDS (NACA), Prof. John Idoko debunks such claim, while giving reports of the activities of the agency (Source: AllAfrica News: HIV-Aids and STDs)
South Africa: Sex Workers Demand Representation On District Aids Council
[Health-e]Sex workers are asking for representation on the Northern Cape's John Taolo Gaetsewe District AIDS Council as sex work soars in local mining community. (Source: AllAfrica News: Health and Medicine)
New partnership to improve access to essential pain medications for people living with HIV
(Elizabeth Glaser Pediatric AIDS Foundation) Today the Elizabeth Glaser Pediatric AIDS Foundation and the American Cancer Society announced a new partnership to improve access to essential pain medications for people living with HIV in Swaziland. As part of ACS' Treat the Pain initiative, this new partnership will help improve efforts to better integrate pain management into HIV/AIDS services throughout the country. (Source: EurekAlert! - Cancer)
Do Decision Aids Help Patients Make Difficult Choices? (CME/CE)
(MedPage Today) -- Decision aids designed to help patients make general healthcare choices, such as selecting a treatment location, provide some help, but condition-specific aids may provide the most useful information for patients and families. (Source: MedPage Today Cardiovascular)
Sticking to minimum standards: implementing antibiotic stewardship in intensive care
ConclusionA systematic approach to quality improvement combined with the implementation of a tailored, multi?faceted intervention can improve antimicrobial prescribing practices. (Source: Internal Medicine Journal)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Charakteristika und Koinfektionen mit Syphilis bei neu mit HIV diagnostizierten Patienten aus dem Universitätsklinikum Dresden von 1987?2012
Zusammenfassung HintergrundKoinfektionsraten von HIV und Syphilis sind über Meldedaten nicht erhältlich und es existiert in Ostdeutschland bisher kein Kollektiv, an dem dies repräsentativ für eine Region ermittelt wurde. Steigende Syphilis?Inzidenzraten 2010?2012 besonders bei Männern mit sexuellen Kontakten zu Männern (MSM) werden als Mitursache für die in dieser Gruppe aktuell wieder steigenden HIV?Neuinfektionsraten diskutiert. Patienten und MethodikDie Charakteristika von 355 konsekutiven, neu mit HIV diagnostizierten Patienten aus dem Universitätsklinikum Dresden von 1987?2012 wurden retrospektiv anhand der Meldedaten für den Dresdner Raum und im Vergleich zu bundesweiten Daten überprüft sowie Koinfektionen mit Syphilis analysiert. ErgebnisseIn unserem Kollektiv fan...
HCV RNA viral load is independent from CD4 cell count and plasma HIV RNA viral load in immunocompetent HIV-HCV co-infected patients: a 3-years follow-up study
Conclusions: The HCV RNA load, a known pretreatment predictor of response to antiviral therapy, was independent of the two main parameters of HIV disease, plasma HIV RNA and CD4 cell count, over an observation time of 3 years in patients with recovered or spontaneously maintained immunocompetence. (Source: AIDS Research and Therapy)
Decision Aids for Advance Care Planning: An Overview of the State of the Science.
Authors: Butler M, Ratner E, McCreedy E, Shippee N, Kane RL Abstract Advance care planning honors patients' goals and preferences for future care by creating a plan for when illness or injury impedes the ability to think or communicate about health decisions. Fewer than 50% of severely or terminally ill patients have an advance directive in their medical record, and physicians are accurate only about 65% of the time when predicting patient preferences for intensive care. Decision aids can support the advance care planning process by providing a structured approach to informing patients about care options and prompting them to document and communicate their preferences. This review, commissioned as a technical brief by the Agency for Healthcare Research and Quality Effective Health ...
Pain anxiety and negative outcome expectations for activity: Negative psychological profiles differ between the inactive and active
Conclusion: Identifying differences in negative psychological factors aids in the understanding of differential adherence between activity groups and highlights possible factors to change in future intervention research. © 2014 American College of Rheumatology. (Source: Arthritis Care and Research)
Breaking Open Public Places: UNFPA Launches Coolibah - 21 July 2014
MELBOURNE, Australia &ndash; At the International AIDS Conference 2014 today, UNFPA, the United Nations Population Fund, launched a youth networking zone called the coolibah, where, throughout the week, it will host a range of activities for and with young people, including a series of luncheons with leaders in the field of HIV and AIDS. (Source: UNFPA News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
UNFPA engages young people in the fight against HIV - 21 July 2014
MELBOURNE, Australia &ndash; Every hour, about 80 young people are newly infected with HIV, according to the recently released Gap Report by UNAIDS. The participation and leadership of young people will therefore be critical in bringing the global HIV epidemic to an end. Today, at the 20th International AIDS Conference, UNFPA launched a youth networking zone called the &lsquo;coolibah&rsquo;, where young people will be able to speak with leaders in the field of HIV and AIDS. (Source: UNFPA News)
Cerebral microsporidiosis manifesting as progressive multifocal leukoencephalopathy in an HIV-infected individual - a case report.
This report underscores the need for physicians to consider microsporidiosis (potentially affecting the brain) when no other etiology is established both in HIV, non-HIV immunosuppressed patients and in immunocompetent individuals. PMID: 25057277 [PubMed] (Source: AIDS Research and Therapy)
Holla from Njeku!
Njeku, a small but beautiful village nestled in a valley at the base of Sakila Mountain. While our time here has been short, the past week has shown great promise for our impact to be anything but small. The village leaders have been helpful, and it seems that most of the people we come across now recognize us as more than just those new visitors in town. As always, Sunday is a great day for worship, and we used this to our advantage. Understanding our mission, the VEO (Village Executive Officer) kindly sent out letters to the various village churches so that they would mention our testing day during their announcements section of their service. The church we have attended for the past two weeks once again welcomed us with open arms. More than others, it seems they have truly accepted us i...
Mambo from the Sakila crew!
This week we finally started teaching in schools, which has been absolutely incredible. We finally feel like we?re doing what we set out to do. In Sakila, we have two primary schools and two secondary schools, and each teaching has been accompanied by unique challenges. We?ll cover a few of the most interesting occurrences here. Our first teaching was Wednesday (July 9th) afternoon at Sakila Secondary School. When we talked to the headmaster, we were told there would be between 50 and 70 students in each Form (grade), but when we showed up, many students had yet to pay their school fees and we ended up teaching classes of 15. This meant we taught our most important lesson to less than half of the student body, which was disappointing. Regardless, this worked as a good trial run to work...
Early Antiretrovirals Shrink HIV Reservoir in NewbornsEarly Antiretrovirals Shrink HIV Reservoir in Newborns
Evidence continues to support starting antiretrovirals immediately after birth to reduce HIV reservoir size and suppress the virus over the long term. Medscape Medical News (Source: Medscape Medical News Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Ghana: Rape Victim Demands HIV Test of Doctor
[Ghanaian Chronicle]The Tema Regional office of the Domestic Violence and Victim Support Unit (DOVVSU), is investigating a medical doctor for allegedly raping a 22-year-old student. (Source: AllAfrica News: HIV-Aids and STDs)
Breaking Open Public Places: UNFPA Launches Coolibah - 21 July 2014
MELBOURNE, Australia &ndash; At the International AIDS Conference 2014 today, UNFPA, the United Nations Population Fund, launched a youth networking zone called the coolibah, where, throughout the week, it will host a range of activities for and with young people, including a series of luncheons with leaders in the field of HIV and AIDS. (Source: UNFPA News)
UNFPA engages young people in the fight against HIV - 21 July 2014
MELBOURNE, Australia &ndash; Every hour, about 80 young people are newly infected with HIV, according to the recently released Gap Report by UNAIDS. The participation and leadership of young people will therefore be critical in bringing the global HIV epidemic to an end. Today, at the 20th International AIDS Conference, UNFPA launched a youth networking zone called the &lsquo;coolibah&rsquo;, where young people will be able to speak with leaders in the field of HIV and AIDS. (Source: UNFPA News)
Nigeria: Report Scores Nigeria Low on HIV/Aids Control
[Guardian]CHUKWUMA MUANYA writes on a new global report which points to slow progress in the fight against HIV/AIDS in Nigeria (Source: AllAfrica News: HIV-Aids and STDs)
Africa: Clinton Says Aids-Free Generation 'Within Reach'
[AlertNet]Melbourne -An AIDS-free generation is within reach if early treatment is provided to people infected with HIV and help scaled up for women and children, former U.S. president Bill Clinton said on Wednesday. (Source: AllAfrica News: Health and Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Kenya: Circumcised Men Not Using Condoms
[The Star]Most men are likely to engage in unprotected sex after being circumcised. A study presented at the 20th International Aids conference indicated that circumcised men don't use condoms owing to the perception that they are at a lower risk of getting HIV. (Source: AllAfrica News: HIV-Aids and STDs)
Routine HIV Screening in New York City and New OrleansRoutine HIV Screening in New York City and New Orleans
This report describes novel HIV screening programs at two urban health care settings, one in New York City and one in New Orleans. Might they serve as models that could be adapted by other facilities? Morbidity & Mortality Weekly Report (Source: Medscape Today Headlines)
Locomotor Functions Over Time in HIV-Infected PatientsLocomotor Functions Over Time in HIV-Infected Patients
How does motor function over time in HIV+ individuals compare with healthy individuals? AIDS (Source: Medscape Today Headlines)
Hoped-for 'AIDS cure' drug fails miserably in monkey experiments; HIV outwits Big Pharma yet again
(NaturalNews) A monkey version of the HIV virus can outwit anti-AIDS drugs just days after entering the body, according to researchers who were disappointed that Big Pharma still cannot produce a human cure for the disease.If the same thing is true for humans, treatment for HIV... (Source: NaturalNews.com)
Kenya: Organization Wants Prostitution Legalized.
[The Star]Sex workers want prostitution legalized so that the country benefits from donor funding. Activist Peninah Mwangi says the government can in turn use the money to carry out HIV/AIDS sensitization campaigns, purchase ARVs and carry out empowerment programmes for sex workers. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Featured in NEJM Journal Watch: Really Rapid Review ? AIDS 2014, Melbourne (FREE)
By the NEJM Journal Watch Editors In his blog HIV and ID Observations, ? (Source: Physician's First Watch current issue)
Breaking Open Public Places: UNFPA Launches Coolibah - 21 July 2014
MELBOURNE, Australia &ndash; At the International AIDS Conference 2014 today, UNFPA, the United Nations Population Fund, launched a youth networking zone called the coolibah, where, throughout the week, it will host a range of activities for and with young people, including a series of luncheons with leaders in the field of HIV and AIDS. (Source: UNFPA News)
UNFPA engages young people in the fight against HIV - 21 July 2014
MELBOURNE, Australia &ndash; Every hour, about 80 young people are newly infected with HIV, according to the recently released Gap Report by UNAIDS. The participation and leadership of young people will therefore be critical in bringing the global HIV epidemic to an end. Today, at the 20th International AIDS Conference, UNFPA launched a youth networking zone called the &lsquo;coolibah&rsquo;, where young people will be able to speak with leaders in the field of HIV and AIDS. (Source: UNFPA News)
Breaking Open Public Places: UNFPA Launches Coolibah - 21 July 2014
MELBOURNE, Australia &ndash; At the International AIDS Conference 2014 today, UNFPA, the United Nations Population Fund, launched a youth networking zone called the coolibah, where, throughout the week, it will host a range of activities for and with young people, including a series of luncheons with leaders in the field of HIV and AIDS. (Source: UNFPA News)
UNFPA engages young people in the fight against HIV - 21 July 2014
MELBOURNE, Australia &ndash; Every hour, about 80 young people are newly infected with HIV, according to the recently released Gap Report by UNAIDS. The participation and leadership of young people will therefore be critical in bringing the global HIV epidemic to an end. Today, at the 20th International AIDS Conference, UNFPA launched a youth networking zone called the &lsquo;coolibah&rsquo;, where young people will be able to speak with leaders in the field of HIV and AIDS. (Source: UNFPA News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Discriminatory Capacity Between HIV-1 and HIV-2 of the New Rapid Confirmation Assay Geenius.
Authors: Herssens N, Beelaert G, Fransen K Abstract The currently used HIV confirmatory assays, Western blot and line immunoassay, are costly, complex and time-consuming. There is a need for cheaper, simpler and faster assays for use in high- and low-resource settings. Furthermore, it is necessary to differentiate between HIV-1 and HIV-2 infection due to differences in disease progression, monitoring and treatment options. Because the new Geenius HIV 1/2 Confirmatory Assay (Bio-Rad) has a European Community (CE) label, this study focused on its differentiation capacity using serum/plasma specimens from established HIV-1, HIV-2 and HIV untypable infections from the AIDS Reference Laboratory (ARL) of the Institute of Tropical Medicine (ITM) in Belgium. The results were compared with ...
This won't be the AIDS-free generation
He was just 18 years old when he got the news. It was the summer before his senior year in high school. Bryan Seth Johnson was diagnosed with the human immunodeficiency virus, better known as HIV. (Source: WDSU.com - Health)
Breaking Open Public Places: UNFPA Launches Coolibah - 21 July 2014
MELBOURNE, Australia &ndash; At the International AIDS Conference 2014 today, UNFPA, the United Nations Population Fund, launched a youth networking zone called the coolibah, where, throughout the week, it will host a range of activities for and with young people, including a series of luncheons with leaders in the field of HIV and AIDS. (Source: UNFPA News)
UNFPA engages young people in the fight against HIV - 21 July 2014
MELBOURNE, Australia &ndash; Every hour, about 80 young people are newly infected with HIV, according to the recently released Gap Report by UNAIDS. The participation and leadership of young people will therefore be critical in bringing the global HIV epidemic to an end. Today, at the 20th International AIDS Conference, UNFPA launched a youth networking zone called the &lsquo;coolibah&rsquo;, where young people will be able to speak with leaders in the field of HIV and AIDS. (Source: UNFPA News)
Mesenteric masses: Approach to differential diagnosis at MRI with histopathologic correlation
Magnetic resonance imaging (MRI) is an outstanding tool for the identification and characterization of mesenteric masses. Mesenteric masses may be solid or cystic. Most solid mesenteric masses are neoplastic, with sclerosing mesenteritis a notable exception. Entirely cystic mesenteric masses are typically benign. The excellent soft?tissue contrast afforded by MRI aids in narrowing the differential diagnosis of mesenteric masses. Accurately characterizing both solid and cystic mesenteric masses is important, as management ranges from active surveillance to medical management to surgical resection, depending on the tissue composition of the mass. An MRI?based approach to the differential diagnosis of mesenteric masses is presented.J. Magn. Reson. Imaging 2014. © 2014 Wiley Periodicals, ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Oral Hepatitis C Drugs Helping Patients Coinfected With HIVOral Hepatitis C Drugs Helping Patients Coinfected With HIV
Results from TURQUOISE-1 and PHOTON-2 show that interferon-free regimens are achieving impressive response rates with few adverse events in patients coinfected with hep C and HIV. Medscape Medical News (Source: Medscape Gastroenterology Headlines)
Nigeria: Nigeria Doctors' Strike Threatens HIV/Aids Care
[VOA]Nearly a month into a nationwide doctor's strike, HIV/AIDS patients in some parts of northern Nigeria say health care is rapidly declining, and they have become largely dependent upon foreign aid organizations. Doctors say the strike is the only way they know to rescue Nigeria's flailing healthcare system, but nurses accuse strikers of abandoning public care in favor of more lucrative private practices. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: Aids Conference Mourns the Dead, Debates Setbacks
[IPS]Melbourne -The 20th International AIDS Conference concluded today as the first in its history that remembered not just the 39 million people worldwide who have died of AIDS but also those who lost their lives in the crashed MH17 flight carrying six of its delegates, one of whom was the past president of the International AIDS Society (IAS). (Source: AllAfrica News: HIV-Aids and STDs)
[World Report] MH17 tragedy: HIV community mourns loss of colleagues
Organisers of this year's International AIDS Conference dedicated the meeting to the delegates who were killed on ill-fated flight MH17. Udani Samarasekera reports. (Source: LANCET)
Humanized PA14 (a monoclonal CCR5 antibody) for treatment of people with HIV infection.
CONCLUSIONS: Limited evidence from three small trials suggests that PRO 140 might demonstrate potent, short-term, dose-dependent, highly significant antiviral activity. However, as the evidence is insufficient, recommendations cannot yet be made. Larger, longer-term, double-blind RCTs are required to provide conclusive evidence. PMID: 25063928 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Considerations for Implementing Oral Pre-exposure Prophylaxis: A Literature Review
Oral pre-exposure prophylaxis (PrEP) is in its infancy as an approved biomedical intervention; therefore, research is needed to understand the issues surrounding its implementation. The purpose of this literature review is to report the empirical research about PrEP to identify the salient issues surrounding its implementation. PubMed, Medline, and CINAHL databases were searched yielding 45 articles meeting inclusion criteria for the review. Overall, we found patient awareness of PrEP varied and its use was low. (Source: Journal of the Association of Nurses in AIDS Care)
Breaking Open Public Places: UNFPA Launches Coolibah - 21 July 2014
MELBOURNE, Australia &ndash; At the International AIDS Conference 2014 today, UNFPA, the United Nations Population Fund, launched a youth networking zone called the coolibah, where, throughout the week, it will host a range of activities for and with young people, including a series of luncheons with leaders in the field of HIV and AIDS. (Source: UNFPA News)
UNFPA engages young people in the fight against HIV - 21 July 2014
MELBOURNE, Australia &ndash; Every hour, about 80 young people are newly infected with HIV, according to the recently released Gap Report by UNAIDS. The participation and leadership of young people will therefore be critical in bringing the global HIV epidemic to an end. Today, at the 20th International AIDS Conference, UNFPA launched a youth networking zone called the &lsquo;coolibah&rsquo;, where young people will be able to speak with leaders in the field of HIV and AIDS. (Source: UNFPA News)
Suicidal ideation among attendees of a West African HIV clinic - Ogundipe OA, Olagunju AT, Adeyemi JD.
This study was set to determine the prevalence of suicidal ideation and the associated risk factors among PLWHA.... (Source: SafetyLit: All (Unduplicated))
Risk factors associated with mental health issues in adolescents: a integrative review
Conclusion: The integrative review allowed to point important questions to be addressed in preventive actions by the health professional, including the nurse, to create a space that works with risk conditioning factors in adolescents for mental health aggravation.?Identificar los factores de riesgo asociados a los problemas de salud mental en adolescentes. Método: Se realizó una revisión integradora de artículos publicados entre los años 2007 y 2013 en cuatro bases de datos. Para la búsqueda de artículos, se utilizaron los descriptores: Salud Mental y Adolescencia, conforme a las bases DeCS/MeSH. Resultados: Se encontraron publicaciones en diferentes revistas, en distintos campos de conocimiento, siendo más frecuentes las investigaciones cuantitativas. Los problemas en salud ment...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Errata
Conclusion: The integrative review allowed to point important questions to be addressed in preventive actions by the health professional, including the nurse, to create a space that works with risk conditioning factors in adolescents for mental health aggravation.?Identificar los factores de riesgo asociados a los problemas de salud mental en adolescentes. Método: Se realizó una revisión integradora de artículos publicados entre los años 2007 y 2013 en cuatro bases de datos. Para la búsqueda de artículos, se utilizaron los descriptores: Salud Mental y Adolescencia, conforme a las bases DeCS/MeSH. Resultados: Se encontraron publicaciones en diferentes revistas, en distintos campos de conocimiento, siendo más frecuentes las investigaciones cuantitativas. Los problemas en salud ment...
This Week: AIDS Progress, Vegan Diet
(MedPage Today) -- Delegates to the IAC step up the pace, a top doctor's decision to go vegan, and disappointing results for robotic surgery topped this week's news at MedPage Today. (Source: MedPage Today Pediatrics)
Staying Sane as Medicine Goes CrazyStaying Sane as Medicine Goes Crazy
Technological advances, greater demands from patients and insurers, and a host of other stressors are pushing doctors to the brink. Despairing as it may sound, there are ways to regain control. Medscape Business of Medicine (Source: Medscape Hiv-Aids Headlines)
HIV Cure Still Years Away (CME/CE)
(MedPage Today) -- MELBOURNE, Australia -- The word "cure" is back in the HIV/AIDS vocabulary but the research is just out of the starting gate. (Source: MedPage Today Infectious Disease)
Controversy over ban on gay men donating blood
A lot has changed since the U.S. banned gay men from donating blood at the height of the AIDS scare in the 1980s; why is the policy still in place? (Source: Health News: CBSNews.com)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
This won't be the AIDS-free generation
In the United States, 26% of all new HIV infections are among young people ages 13 to 24. Yet only 1 in 5 high school students is tested for HIV. (Source: CNN.com - Health)
More Positive Stories Needed: HIV in Countries with Low ARV Therapy Coverage
  By Cecilia Ferreyra, MSF HIV & TB Technical Advisor More than 24 million people living with HIV; 9 million people on antiretroviral treatment (ART); 1.5 million new infections; 1.1 million deaths from AIDS-related causes. These are some of the data just released by UNAIDS on HIV/AIDS in sub-Saharan Africa in 2013, by far the area of ??the world hardest-hit by the virus. But, in this broad area covering nearly the entire continent, we see very different realities. (Source: MSF News)
Kenya: We Need a New Strategy to Fight HIV in Nyanza
[The Star]The Kenya HIV Prevention Revolution Road Map gives the glaring disparities in the number of HIV infections in all the 47 counties. Nairobi tops the list with close to 1.8 million HIV-positive people followed by all the counties in Nyanza except Nyamira. (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: Group's Pledge to Fight HIV
[The Star]AN International HIV campaign programme has pledged to partner with the Homa Bay county government to reduce the spread of the disease. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Kenya: Young Men Report Having Several Sex Partners
[The Star]Young men between 15 and 24 years are sexually active and have multiple partners. A HIV report by the health ministry also reveals that a majority of women start having sex when they are 17 years. The report recommends behavioral change and condom use promotion. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: HIV/Aids - More Positive Stories Needed
[MSF]As HIV & TB Technical Advisor for Médecins Sans Frontières (MSF), I have just returned from South Sudan, where I visited our project in Yambio, in Western Equatorial state. MSF supports the national HIV/AIDS programme there, with a special focus on pregnant women and children under five years of age. In general, the situation in South Sudan is the reality of many countries in West and Central Africa, where assistance to HIV-positive people is ineffective or nonexistent; and where conflict (Source: AllAfrica News: HIV-Aids and STDs)
Lift U.S. Ban on Blood Donations by Gay Men, Experts Say
American Red Cross, other groups also urge easing restrictions due to better blood screening (Source: Fertility News - Doctors Lounge)
Kenya: More Funding Needed for TB-HIV Co-Infection
[Key Correspondents]HIV and tuberculosis advocates say failure by donors and governments to invest more in these diseases may thwart efforts to end both epidemics resulting in thousands of preventable deaths. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: Young People Must Play Leading Role in HIV Advocacy
[Key Correspondents]Delegates at the AIDS 2014 conference (20-25 July) are recognising that young people are the future and it is vital to empower them to take a leading role in the response to HIV. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Africa: Post 2015 Development Agenda and HIV - the Epidemic's Way Forward
[Key Correspondents]The end of AIDS has to be at the centre of the post-2015 development agenda to ensure the holistic, socio-economic development of communities around the world. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: Young People Speak Out Against Stigma of Youth Condom Use
[Key Correspondents]Young people around the world are not receiving clear messages or support to use condoms to prevent HIV infection, according to delegates at the AIDS 2014 conference in Melbourne, Australia (20-25 July). (Source: AllAfrica News: Health and Medicine)
Africa: HIV Eradication Remains Challenging Milestone for Scientists
[Key Correspondents]"How come we have been able to fit everything that life needs into one mobile phone device we can keep in our pockets, but cannot find the cure for HIV?" This was a question a young man asked Dr Francoise Barre-Sinnousi, the International AIDS Society chief executive, in a discussion at the AIDS 2014 conference in Melbourne, Australia. (Source: AllAfrica News: Health and Medicine)
Africa: At Aids Conference, Prevention Pill Stirs Excitement
[VOA]Participants in this year's International AIDS Conference welcomed progress on a new pill that may prevent transmission of the deadly HIV virus - one of the advances that have provoked celebrations as well as debates. (Source: AllAfrica News: Health and Medicine)
Number of new HIV infection has decreased by 57%: Harsh Vardhan
Govt's objective was to reduce new infections further by 50% and provide comprehensive care and support to all persons living with HIV and AIDS. (Source: The Economic Times)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
Breaking Open Public Places: UNFPA Launches Coolibah - 21 July 2014
MELBOURNE, Australia &ndash; At the International AIDS Conference 2014 today, UNFPA, the United Nations Population Fund, launched a youth networking zone called the coolibah, where, throughout the week, it will host a range of activities for and with young people, including a series of luncheons with leaders in the field of HIV and AIDS. (Source: UNFPA News)
UNFPA engages young people in the fight against HIV - 21 July 2014
MELBOURNE, Australia &ndash; Every hour, about 80 young people are newly infected with HIV, according to the recently released Gap Report by UNAIDS. The participation and leadership of young people will therefore be critical in bringing the global HIV epidemic to an end. Today, at the 20th International AIDS Conference, UNFPA launched a youth networking zone called the &lsquo;coolibah&rsquo;, where young people will be able to speak with leaders in the field of HIV and AIDS. (Source: UNFPA News)
Africa: Police Must Play Role in Preventing HIV Among Criminalised Groups
[Key Correspondents]Delegates at the 20th International AIDS conference are tackling the issue of law enforcement policies and practices that often undermine the efforts of public health officials to reduce HIV transmission. (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: HIV Related Complications Killed 58 Thousand Kenyans Last Year
[The Star]More than 58 thousand people died due to HIV related complications last year. A report by health ministry shows that the number of deaths of women were at 27,000, men at about 21,000 and children at 10,000. (Source: AllAfrica News: HIV-Aids and STDs)
Diagnostic role of ultrasound and elastosonography in nodular goiter.
Authors: Rago T, Vitti P Abstract Among several ultrasound patterns, thyroid nodule hypoechogenicity, spot microcalcifications, and an absent halo sign are used for predicting increased risk of thyroid malignancy. The predictive value of ultrasound, however, increases at the expense of its sensitivity, and malignancy is predicted with high specificity only when multiple ultrasound features are simultaneously present. Ultrasound features are important in determining the strength of the indication for carrying out fine needle aspiration. To this end, a system for standardization of ultrasound features (Thyroid Imaging Reporting and Data System) aids in establishing risk of malignancy. Ultrasound elastosonography is a technique that assesses hardness as an indicator of malignancy risk...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>
New licensing agreement could improve treatment options for children living with HIV
(Elizabeth Glaser Pediatric AIDS Foundation) The Elizabeth Glaser Pediatric AIDS Foundation applauds the new licensing agreement between the Medicines Patent Pool and Gilead Sciences, Inc. to improve access to tenofovir alafenamide fumarate, a promising new HIV medication. The agreement was announced during the 20th International AIDS Conference in Melbourne, Australia. While tenofovir alafenamide fumarate is still in Phase III clinical trials, early data suggests it could be a key ingredient in the next generation of first-line fixed-dose treatment options for children living with HIV. (Source: EurekAlert! - Infectious and Emerging Diseases)
Commissioning of hearing aids: response to Hearing Link?s campaign
The campaign, organised by Hearing Link, was called ?Stop the cuts to hearing aid services?. (Source: NHS Networks)
Maternal and health care workers' perceptions of the effects of exclusive breastfeeding by HIV positive mothers on maternal and infant health in Blantyre, Malawi
Conclusion: While most participants considered exclusive breastfeeding as an important component of the wellbeing of their infants' health, they did not share the worldwide acknowledged benefits of exclusive breastfeeding in the prevention of mother-to-child transmission (PMTCT) of HIV. These results suggest a need for more breastfeeding education for all mothers, communities and nurse-midwives involved in breastfeeding counseling in the context of HIV infection. Maternal wellbeing promotion activities such as nutrition supplementation need to be included in all PMTCT of HIV programs. (Source: BMC Pregnancy and Childbirth - Latest articles)
Progress toward prevention of transfusion-transmitted hepatitis B and hepatitis C infection - sub-saharan Africa, 2000-2011.
This report summarizes HBV- and HCV-related surveillance data reported by the blood transfusion services of WHO member states to WHO's Global Database on Blood Safety (GDBS) (4). It also evaluates the performance of blood safety programs in screening for HBV and HCV in 38 sub-Saharan Africa countries.* Selected GDBS indicators were compared for the years 2000 and 2004 (referred to as the 2000/2004 period) and 2010 and 2011 (referred to as the 2010/2011 period). From 2000/2004 to 2010/2011, the median of the annual number of units donated per country increased, the number of countries screening at least 95% of blood donations for HBV and HCV increased, and the median of the national prevalence of HBV and HCV marker-reactive blood donations decreased. These findings suggest that during the p...

 

 


   Origin of HIV/AIDS
By Anil Shaw
 Origin of HIV/AIDSMost people believe that the origin of HIV, the AIDS virus, derives from some natural evolutionary event. The HIV origin theories is called "cut hunter Read more...

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