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CD4 Cells
By Afsath Jameela

CD4 Cells
Treatment centers need consulting rooms, offices, waiting rooms and secure storage for valuable drugs. They also require basic facilities to test for anemia, pregnancy, renal function, white blood cell counts and other factors that may affect treatment.
In developed countries, decisions about when to start treatment are based on the results of clinical tests called the CD4 test and the viral load test. Ideally these tests should be used everywhere, but in many parts of the world they are currently unavailable, as they require expensive equipment, electricity and trained technicians. In theory, decisions about when to start treatment may be based on symptoms alone. However in practice some treatment programmers provide medication only to people who have had a CD4 count.
There are two primary types of T-cells.
1. CD4 Cells-These cells have molecules called CD4 on its surface. These "helper" cells initiate the body's response to invading micro-organisms such as viruses.
2.CD8 Cells-These types of T-cells have a molecule called CD8 on their surface. CD8 cells destroy cells that have been infected with foreign invading micro-organisms. CD8 cells also produce antiviral substances (antibodies) that help fight off the foreign invader.
3.Normal values-In a healthy adult, a normal CD4 count can vary a great deal but is typically 600 to 1200 cells per cubic millimeter of blood
Between 600 and 350- In an HIV+ person, this range is considered "very good".
HIV medications are typically not be indicated.
Between 350 and 200-The immune system is weakened and therefore the HIV+ person may be at increased risk for infection and illness.
Function of T helper cells: Antigen presenting cells present antigen on their Class II MHC molecules. Helper T cells recognize these, with the help of their expression of CD4 co-receptor. The activation of a resting helper T cell causes it to release cytokines and other stimulatory signals. The importance of CD4 T cells is demonstrated with infection.
It has been proposed that during the non-symptomatic phase of infection, the virus has a relatively low affinity towards T cells (and has a higher affinity for macrophages), resulting in a slow kill rate of CD4+ T cells by the immune system. This is initially compensated for via the production of new helper T cells from thymus. Once the virus becomes T-tropic, it begins to infect CD4+ T cells far more efficiently, and

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'ABCD 2' dancer arrested for gang-rape of mentally challenged girl - DNA: Top News
Remo D?Souza?s last release, ABCD 2 starring Varun Dhawan and Shraddha Kapoor has been talk of the town ever since the makers released the promo of the film. The film is making headlines yet again but for a terrible reason this time around. A back up dancer from the film, Nilesh Nirbhavane has been arrested for raping a 14 year old mentally challenged girl. Nilesh, a dancer by profession, was arrested by the Pant Nagar Police on June 26 when he confessed his crime. An officer from the Pant Nagar Police station informed a leading daily that Nilesh had been raping the girl repeatedly for a month along with a friend. They would take the girl to public toilets or other isolated places and then rape her. Reportedly, the girl?s teacher observed that she had been behaving abnormally for some time. When the teacher questioned her, she (teacher) found out that the teenager was being abused sexually by three boys. She informed about the same to the girl?s parents who then filed a complaint at the Pant Nagar Police ...
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Mumbai: Soon after 'ABCD 2' garnered headlines for maintaining a strong foothold at the box-office, here is another news that shocked their fans completely. Mumbai Police have arrested Nilesh Nirbhavane, a back-up dancer in ABCD 2, for raping a 14-year-old mentally challenged girl. Nilesh, a dancer by profession, was arrested by the Pant Nagar Police on June 26 when he confessed his crime. According to reports, an officer from the Pant Nagar Police station informed a leading daily that Nilesh had been raping the girl repeatedly for a month along with a friend. They would take the girl to public toilets or other isolated places and then rape her. Nilesh, who confessed to the crime after the officer called him for questioning, was booked under IPC sections 376D (gang rape), 377 (unnatural offences) and 34 (acts done by several persons in furtherance of common ...
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Poor sleep is associated with negative mood in women with bipolar disorder, says a new study.
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Washington, July 1 : Poor sleep is associated with negative mood in women with bipolar disorder, says a new study.
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?ABCD 2? dancer Nilesh Nirbhavane arrested for gang rape - Asian Age: India
Mumbai: Soon after 'ABCD 2' garnered headlines for maintaining a strong foothold at the box-office, here is another news that shocked their fans completely. Mumbai Police have arrested Nilesh Nirbhavane, a back-up dancer in ABCD 2, for raping a 14-year-old mentally challenged girl. Nilesh, a dancer by profession, was arrested by the Pant Nagar Police on June 26 when he confessed his crime. According to reports, an officer from the Pant Nagar Police station informed a leading daily that Nilesh had been raping the girl repeatedly for a month along with a friend. They would take the girl to public toilets or other isolated places and then rape her. Nilesh, who confessed to the crime after the officer called him for questioning, was booked under IPC sections 376D (gang rape), 377 (unnatural offences) and 34 (acts done by several persons in furtherance of common ...
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Two crore households have differently-abled - Asian Age: India
The latest census data on disabled persons has shown an increase in households which have disabled persons with as many as 2.08 crore households in the country having differently-abled persons. Together they constitute 8.3 per cent of the total homes, as per the 2001-11 Census data released by the government on Tuesday. The data on disabled population has been released by types of disability, households and gender. According to the 2011 data released by registrar-general and Census commissioner of India Tues-day, out of the total households having disabled persons, about 99 per cent homes are normal homes, 0.4 per cent are institutional and 0.2 per cent are house-less households. The differently-abled living in different types of households have further been cross-classified into eight different disabilities i.e. seeing, hearing, speech, movement, mental retardation, mental illness, multiple disability for India, States and Union Territories. Total households having disabled persons has shown an increase ...
Mentally-challenged girl raped - Hindu: National
A 20-year-old mentally-challenged girl was raped by two youth. The incident took place at Tornal village in Siddipet mandal of Medak district on Tuesday.According to Siddipet (Rural) Sub-Ins...
Two crore households have differently-abled - Asian Age: India
The latest census data on disabled persons has shown an increase in households which have disabled persons with as many as 2.08 crore households in the country having differently-abled persons. Together they constitute 8.3 per cent of the total homes, as per the 2001-11 Census data released by the government on Tuesday. The data on disabled population has been released by types of disability, households and gender. According to the 2011 data released by registrar-general and Census commissioner of India Tues-day, out of the total households having disabled persons, about 99 per cent homes are normal homes, 0.4 per cent are institutional and 0.2 per cent are house-less households. The differently-abled living in different types of households have further been cross-classified into eight different disabilities i.e. seeing, hearing, speech, movement, mental retardation, mental illness, multiple disability for India, States and Union Territories. Total households having disabled persons has shown an increase ...
Bullet rips apart villager?s family - The Telegraph : North East
Till June 3, five-year-old Sabilal and his three-year-old brother Sanilal played together in the courtyard of their home.
Over 8 Percent of Indian Households Have Disabled People - newindianexpress.com
207.8 lakh, of the total households in the country have disabled persons, reveals data on disabled population in India.
Number of disabled rises 18 pc in 10 years - deccanherald.com
The number of people with disabilities in India has touched 2.68 crore — an increase of 49.09 lakh, or 18 per cent, in 10 years — with 70 per cent of them living in rural areas. According to Census 2011 figures published on Tuesday, these people live in 2.07 crore households, which is 8.3 per cent of total households in the country. People facing challenges in movement top the list with 54.36 lakh, followed by the hearing impaired (50.72 lakh) and the visually impaired (50.33 lakh). Among the 2.68 crore disabled people, which includes 1.18 crore lakh women, Uttar Pradesh houses the most number of disabled (41.57 lakh), followed by Maharashtra (29.63 lakh) and Bihar (23.31 lakh). Karnataka, with 13.24 lakh disabled, is eighth on the list, while national capital Delhi has 2.34 lakh people with disabilities. The fresh census figures come at a time when the Right of Persons with Disabilities Bill 2014, which mandates reservation in education and employment, preference in government schemes and ...
?????? ??????????? ???????? ????????? ???? ???????? ??????? ?-? ?????? - Oneindia.in: News
??????, ?? ??? : ?????? ???? ?????? ??? ??????? ?-?? ?? ????? ?? ????????? ???????? ???????? ????? ?????? ??????, ?????? ??????????? ?? ???????? ????? ?????? ?? ???????????? ?????? ???? ???????? ????????? ????? ?????? ?????? ???? ???? ?????? ??? ????????? ????? ???????<img src="http://feeds.feedburner.com/~r/oneindia-all-news/~4/arTe5QO-AhI" height="1" width="1" alt=""/>
2.08 crore households in India have disabled persons: Census - deccanherald.com
As many as 2.08 crore households in the country have differently-abled persons constituting 8.3 per cent of the total homes, the 2001-11 Census data said today. According to the 2011 data released by Registrar General and Census Commissioner of India today, out of the total households having disabled persons, about 99 per cent homes are normal homes, 0.4 per cent are institutional and 0.2 per cent are house-less households. The data on disabled population has been released by types of disability, households and gender. The differently-abled living in different types of households are further cross-classified into eight different disabilities i.e. seeing, hearing, speech, movement, mental retardation, mental illness, multiple disability for India, States and Union Territories. Total households having disabled persons has shown an increase of 20.5 lakhs, from 187.3 lakhs in 2001 to 207.8 lakhs in 2011. Of these, 6.2 lakhs are in rural and 14.3 lakhs in urban areas. The differently-abled in normal ...
Over 8 percent of Indian households have disabled persons - Moneylife
As many as 2.08 crore households in the country have differently-abled persons constituting 8.3 per cent of the total homes, the 2001-11 Census data said today. According to the 2011 data released by Registrar General and Census Commissioner of India today, out of the total households having disabled persons, about 99 per cent homes are normal homes, 0.4 per cent are institutional and 0.2 per cent are house-less households. The data on disabled population has been released by types of disability, households and gender. The differently-abled living in different types of households are further cross-classified into eight different disabilities i.e. seeing, hearing, speech, movement, mental retardation, mental illness, multiple disability for India, States and Union Territories. Total households having disabled persons has shown an increase of 20.5 lakhs, from 187.3 lakhs in 2001 to 207.8 lakhs in 2011. Of these, 6.2 lakhs are in rural and 14.3 lakhs in urban areas. The differently-abled in normal ...
Mumbai Shocker: Mentally-challenged minor girl gangraped, ABCD2 dancer arrested - Oneindia.in: News
Mumbai, June 30: 20-year-old Nilesh Nirbhavane, a back up dancer who acted in the recently released movie ABCD2, has been arrested. Nilesh along with his two other friends has been accused of raping a mentally-challenged minor girl. According to media reports,<img src="http://feeds.feedburner.com/~r/oneindia-all-news/~4/9_PWwJUVS5c" height="1" width="1" alt=""/>
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Vadodara: A mentally challenged man who was chained to a pillar at his home in a village in neighbouring Mahisagar district for last several years was rescued by police and shifted to hospital. The 35-year-old man, identified as Ramabhai Nanabhai Damor, became mentally disturbed apparently after he was bitten by a snake about 15 years ago at a forest near Dadavanta village in Mahisagar&apos;s Khanpur taluka, nearly 100 km from Vadodara. After the snake bite incident, he ran away from home on several occasions because of which his mother kept him tied with a chain to a pillar at home, District Superintendent of Police Usha Rada said. &quot;He was rescued yesterday and shifted to a hospital in Bakrol town,&quot; she said. His mother works as a farm labourer to support her family of three members, including Ramabhai and his younger brother, Rada said. She used to tie him up because he had the habit of running away from home, the SP said adding that a villager informed police about it following which they went to his house ...
Over 8 percent of Indian households have disabled persons - All News-IANS Stories
Over eight percent, or 207.8 lakh, of the total households in the country have disabled persons, reveals data on disabled population in India released here on Tuesday.
Gujarat: Man chained for several years rescued - Zee News : States
A mentally challenged man who was chained to a pillar at his home in a village in neighbouring Mahisagar district for last several years was rescued by police and shifted to hospital.

the immune system is overwhelmed.
At this point, functional CD4+ T cell levels begin to decrease, eventually to a point where the CD4+ T cell population is too small to recognize the full range antigens that could potentially be detected. The lack of full antigen cover results in the core symptoms of acquired immune deficiency syndrome (AIDS).CD4 T cell depletion during AIDS allows various pathogens to escape T cell recognition, thus allowing opportunistic infections that would normally elicit a helper T cell response to bypass the immune system. While these complete bypass situations only occur when the helper T cell response is absolutely necessary for infection clearance, most infections increase in severity and/or duration because the immune system's helper T cells provide a weaker contribution to a less efficient immune response.
Two components of the immune system are particularly affected in AIDS, due to its CD4+ T cell dependency:
CD8+ T cells are not stimulated as effectively during the AIDS period of infection, making AIDS patients very susceptible to most viruses, including itself. This decline in killing of CD4+ T cells results in the virus being produced for a longer period (the infected CD4+ T cells are not killed as quickly), increasing the proliferation of the virus, and accelerating the development of the disease.
Antibody class switching declines significantly once helper T cell function fails. The immune system loses its ability to improve the affinity of their antibodies, and are unable to generate B cells that can produce antibody groups such as IgG and IgA. These effects are primarily due to the loss of any helper T cell that can interact with the B lymphocyte correctly. Another symptom of AIDS is the reduction in antibody levels due to a decrease in Th2 cytokines (and less interactions by helper T cells). All of these complications result in an increased susceptibility to aggressive bacterial infections, especially in areas of the body not accessible by IgM antibodies.
If the patient does not respond to Treatment they will succumb usually to either cancers or infections; the immune system finally reaches a point where it is no longer coordinated or stimulated enough to deal with the disease.

 Keywords:  HIV,AIDS,HIV Cure,HIV Treatment,HIV Infection,HIV Dating,HIV Positive,HIV Symptoms.


Afsath Jameela is a successful lady writer from Kairo. She right now living in UK.

Persistence of hepatitis A virus antibodies after primary immunization and response to revaccination in children and adolescents with perinatal HIV exposure
CONCLUSIONS: The antibodies levels acquired in the primary vaccination in the HIV group were the main factor associated with antibodies loss after HAV immunization. OBJETIVO: Avaliar possíveis fatores associados à perda de anticorpos para o vírus da hepatite A (VHA) sete anos após a imunização primária e resposta à revacinação em crianças nascidas de mães soropositivas para HIV nos pacientes soronegativos para Hepatite A. MÉTODOS: Quantificação de anticorpos para o VHA por meio da eletroquimioluminescência foi feita em 39 adolescentes acompanhados no Ambulatório de Aids Pediátrica da Universidade Federal de São Paulo (Unifesp): 29 infectados pelo HIV e 10 expostos e não infectados (ENI) pelo HIV, com mediana de idade, respectivamente, de 12,8 e 13,4 anos. Todos recebera...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Cuba named first country to end mother-to-child HIV transmission
The World Health Organization hailed ?one of the greatest public health achievements possible?, adding that it was ?an important step towards having an Aids-free generation?. (Source: the Mail online | Health)
Condoms, Lubricants and Rectal Cleansing: Practices Associated with Heterosexual Penile-Anal Intercourse Amongst Participants in an HIV Prevention Trial in South Africa, Uganda and Zimbabwe
Abstract We investigated condom and lubricant use, rectal cleansing and rectal gel use for penile-anal intercourse (PAI), during in-depth interviews with women from South Africa, Uganda and Zimbabwe who formerly participated in VOICE, a five-arm HIV prevention trial of two antiretroviral tablets and a vaginal gel. Few studies have addressed practices related to PAI among women; existing data from Africa on condom and lubricant use for PAI, as well as preparatory practices of PAI such as rectal cleansing, are limited to men who have sex with men. Women demonstrated a lack of awareness of HIV transmission risks of PAI and none of the participants reported using condom-compatible lubricants for PAI. Participants described a variety of preparatory rectal cleansing practices. Some part...
The Role of Statins in the Setting of HIV Infection
Abstract HIV-infected individuals are at an increased risk of cardiovascular disease (CVD) and other HIV-related co-morbidities. This is due in part to dyslipidemia associated with antiretroviral therapy and increased inflammation and immune activation from chronic HIV infection. Statins not only have potent lipid-lowering properties but are also anti-inflammatory and immunomodulators. Studies suggest that statin therapy in the HIV-infected population may decrease the risk of CVD and other non-AIDS-defining co-morbidities. This review summarizes the recent literature on statin use in the HIV setting. (Source: Current HIV/AIDS Reports)
Eosinophilia in Patients Infected with Human Immunodeficiency Virus
Abstract Eosinophilia is not uncommonly encountered in patients infected with human immunodeficiency virus (HIV), particularly at initiation of care or among those with advanced disease. The clinical manifestation most commonly associated with eosinophilia in this patient population is skin rash. Management of these patients is challenging due to a paucity of data evaluating diagnostic testing and therapeutic strategies. Patients born in or with significant travel to parasite-endemic countries are more likely to have tissue-invasive helminthes, such as Strongyloides or Schistosoma. Patients without such risk factors are unlikely to have parasitic infections and frequently will have self-resolution of eosinophilia. When a detailed history, physical exam, and diagnostic work-up are ...
Asymmetric Hearing During Development: The Aural Preference Syndrome and Treatment Options
Deafness affects ~2 in 1000 children and is one of the most common congenital impairments. Permanent hearing loss can be treated by fitting hearing aids. More severe to profound deafness is an indication for cochlear implantation. Although newborn hearing screening programs have increased the identification of asymmetric hearing loss, parents and caregivers of children with single-sided deafness are often hesitant to pursue therapy for the deaf ear. Delayed intervention has consequences for recovery of hearing. It has long been reported that asymmetric hearing loss/single-sided deafness compromises speech and language development and educational outcomes in children. Recent studies in animal models of deafness and in children consistently show evidence of an "aural preference syndrome" in ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Improvement in Perinatal HIV Status Documentation in a Massachusetts Birth Hospital, 2009-2013
CONCLUSIONS: We demonstrated improvement in maternal HIV status documentation on admission to labor and delivery after implementation of a 3-pronged intervention. Next steps include investigating persistent barriers to achieving universal screening and documentation. (Source: PEDIATRICS)
David Flanagan Bikes 545 Miles In AIDS/LifeCycle Ride For His Late Gay Son
Despite a celebratory weekend for the lesbian, gay, bisexual and transgender (LGBT) commmunity, one dad's sobering story is reminding us how far we still have to go to make life better for queer people everywhere. Dad David Flanagan just completed the 2015 AIDS/LifeCycle ride, an annual 7-day bike trek from San Francisco to Los Angeles that raises money and awareness for the fight against HIV/AIDS. YouTuber Davey Wavey went on the road with Flanagan to help him share his son's story and get first hand experience in the AIDS/LifeCycle event. For Flanagan and his wife, who was a roadie on the trip, the experience is extremely personal, as they recently lost their son Joshua to HIV/AIDS. "If you think that you might need to be tested or you come across a situation where you might need to be t...
Population-based human immunodeficiency virus 1 drug resistance profiles among individuals who experienced virological failure to first-line antiretroviral therapy in Henan, China during 2010-2011.
CONCLUSION: Multiple and complex patterns of HIV-1 drug resistance mutations were identified among individuals who experienced virological failure to first-line ART in Henan, China during 2010-2011. Therefore, timely virological monitoring, therapy adjustments, and more varieties of drugs and individualized treatment should be immediately considered in this patient population. PMID: 26120348 [PubMed] (Source: AIDS Research and Therapy)
Nigeria: Spread HIV in Ondo, Go to Jail for 10 Years, Govt Warns
[This Day] The Ondo State Government has announced the commencement of the implementation of its HIV anti-stigma law which prescribed a 10-year jail term, fine of N500,000 or both for any person who by whatever means transmits HIV to another person. (Source: AllAfrica News: HIV-Aids and STDs)
HIV Testing and Awareness of Partner?s HIV Status Among Chinese Men Who Have Sex with Men in Main Partnerships
Abstract Many men who have sex with men (MSM) do not use condoms with their main partners, especially if both parties are of the same HIV status. However, significant proportions of MSM have never tested or recently tested and are unaware of their main partners? HIV status. A cross-sectional survey was conducted among 524 MSM in Jiangsu, China in 2013?2014. Time-location sampling and online convenience sampling were used to recruit participants. We compared awareness of HIV status and recent HIV testing between participants who had main partners versus those who did not, and identified factors associated with recent HIV testing among men in main partnerships. Participants in main partnerships were significantly more likely to report recent HIV testing and being HIV-negative in...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Sex Differences in HIV Prevalence, Behavioral Risks and Prevention Needs Among Anglophone and Francophone Sub-Saharan African Migrants Living in Rabat, Morocco
Abstract Morocco has experienced a dramatic increase of migration from sub-Sahara Africa during the past decade. Recently included among the most vulnerable populations cited in the Morocco National Strategic Plans on HIV/TB for 2012?2016, sub-Saharan Africa migrants living in an irregular administrative situation participated in a survey to provide baseline data about their socio-demographic, sexual and HIV testing behaviors and HIV and syphilis prevalence. Two surveys using respondent driven sampling were conducted in 2013 among males and females, ?18 years, originating from sub-Saharan African countries and living and/or working in an irregular administrative situation in Rabat and residing at least 3 months in Morocco. Analysis was conducted to evaluate differences betw...
Depressive Symptoms, Substance Use and Partner Violence Victimization Associated with HIV Disclosure Among Men Who have Sex with Men
Abstract HIV continues to disproportionately affect men who have sex with men (MSM). Depression and substance use have been shown to be risk factors of partner violence among male same-sex couples. However, research exploring the risk factors for partner violence victimization after HIV disclosure among MSM is limited. The aim of this study was to determine the association between depressive symptoms, substance use, and disclosure-associated verbal and/or physical violence from a partner among MSM. Data were obtained from 340 HIV-positive MSM. Multivariable logistic regression was used to determine the associations between Center for Epidemiologic Studies-Depression and substance use scores, and disclosure-associated partner violence. After adjusting for age and income, every one-...
Post-exposure prophylaxis awareness for HIV in India
Conclusion Suggestive measures in the direction of greater emphasis on HIV/AIDS and its PEP in the dental curriculum and training emerge necessary with three quarter agreement about revision in teaching. With only 60% sample willing to treat HIV patients, a greater sensitivity about this much-stigmatized population must also be ensured through an exposure to diverse patient population and regulation of ethical practices for dentists. (Source: Clinical Epidemiology and Global Health)
TOE1 as an anti-HIV factor [Immunology and Inflammation]
Nearly three decades ago, soon after the recognition of AIDS and its causative agent, HIV, the first immune response against the AIDS virus was identified: an unexpected anti-HIV activity of CD8+ cells that did not involve cell killing (1). This immune response differed from the classic CD8+ cell antiviral activity... (Source: Proceedings of the National Academy of Sciences)
Trends in hospital deaths among human immunodeficiency virus?infected patients during the antiretroviral therapy era, 1995 to 2011
CONCLUSIONSNon?AIDS deaths increased significantly during the ART era and are now the most common cause of in?hospital deaths; non?AIDS infection, cardiovascular and liver disease, and malignancies were major contributors to mortality. Higher CD4 cell count, liver, and cardiovascular comorbidities were most strongly associated with non?AIDS deaths. Interventions targeting non?AIDS?associated conditions are needed to reduce inpatient mortality among HIV?infected patients. Journal of Hospital Medicine 2015. © 2015 Society of Hospital Medicine (Source: Journal of Hospital Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Paid Support Workers for Adults with Intellectual Disabilities; Their Current Knowledge of Hearing Loss and Future Training Needs
ConclusionsCurrent training is not sufficient to provide the skills for detection and management of hearing problems. This group had clear ideas on methods of learning. Working in collaboration is necessary to achieve long?term change to practice. (Source: Journal of Applied Research in Intellectual Disabilities)
ICYMI: The Perils Of A Bad Mug Shot And Why STD-Testing Condoms Might Not Be That Awesome
ICYMI Health features what we're reading this week. This week, first-person essays by individuals affected by stigmatized diseases and disorders caught our eye. We spent time with the account of a writer struggling with chronic kidney damage from the lithium she has used to manage her bipolar disorder for 20 years. We had our hearts broken reading about a sister who had to pick up the pieces after her talented sibling died of a drug overdose. And we tuned in when a handful of a celebrities described how it feels to have a panic attack -- a good reminder that anxiety can affect anyone, regardless of life circumstances. Read on and tell us in the comments: What did you read and love this week? 1. The New Normal: Navigating Life After Harris' Death -- The Huffington Post A heart-wrenching ...
The Quality Of Health Care You Receive Likely Depends On Your Skin Color
Unequal health care continues to be a serious problem for black Americans. More than a decade after the Institute of Medicine issued a landmark report showing that minority patients were less likely to receive the same quality health care as white patients, racial and ethnic disparities continue to plague the U.S. health care system. That report, which was published in 2002, indicated that even when both groups had similar insurance or the same ability to pay for care, black patients received inferior treatment to white patients. This still hold true, according to our investigation into dozens of studies about black health across multiple disciplines. More than any other single group, the black community is most likely to have negative health outcomes, including higher rates of breast and ...
Why Larry Kramer's Galvinizing Message About LGBT Activism Is The Same As It's Always Been
?I still have that anger and I would still like to galvanize everyone, but it doesn?t appear that we?re galvanize-able as a population,? AIDS activist, author and playwright Larry Kramer said, discussing why LGBT activism is so necessary at a time in which he fears complacency has set in. That anger is on full display in the new documentary about his life and work as an activist and writer, ?Larry Kramer in Love and Anger,? which debuts on HBO tonight at 9 p.m. ?[It?s] too bad,? he continued, in an interview with me on SiriusXM Progress, referring to the the vital work ahead for activists on AIDS and LGBT rights,?because we need activism more than ever now.? That message ? ?we need activism more than ever now? -- is actually the message Kramer, who turned 80 la...
Botswana: Government Appeals ARV Judgement
[Botswana Daily News] Gaborone -Justice Ian Kirby of the Court of Appeal will tomorrow (June 30) preside over a case in which the Attorney General is appealing Justice Key Dingake's judgement on provision of ARVs to foreign inmates. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Uganda: Aids Fight Gets Shs 745 Billion Boost
[Observer] Uganda last week got five grants worth $226m (Shs 745bn) from the Global Fund to fight Aids, Tuberculosis and Malaria (GFATM). (Source: AllAfrica News: HIV-Aids and STDs)
Subtype-independent near full-length HIV-1 genome sequencing and assembly to be used in large molecular epidemiological studies and clinical management.
CONCLUSIONS: Our high efficiency subtype-independent HIV-NFLG is a simple and promising approach to be used in large-scale molecular epidemiological studies. It will facilitate the understanding of the HIV-1 pandemic population dynamics and outline effective intervention strategies. Furthermore, it can potentially be applicable in clinical management of drug resistance by evaluating DRMs against all available antiretrovirals in a single assay. PMID: 26115688 [PubMed - as supplied by publisher] (Source: Journal of the International AIDS Society)
Africa: WCC Group Evaluates Ecumenical HIV and Aids Response
[WCC] A World Council of Churches (WCC) group concluded a three-day meeting by acknowledging achievements that have been made in addressing HIV and AIDS. (Source: AllAfrica News: HIV-Aids and STDs)
Routine HIV Testing Within the ED of a Major Trauma CentreRoutine HIV Testing Within the ED of a Major Trauma Centre
Should HIV testing be routine for every patient in the emergency department? HIV Medicine (Source: Medscape Today Headlines)
Angola: Over 100 Women Hold HIV/Aids Test
[ANGOP] Uíge -At least one hundred and two women have held in the last seven days, at the Mother and Child Centre of Pedreira Quarter, HIV/AIDS tests, overcoming 97 women in the previous week, said Friday to ANGOP the head of the institution, Tussamba Jose. (Source: AllAfrica News: Health and Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Tanzania: Kilimanjaro Excels in HIV Mother-to-Child Transmission Prevention
[Daily News] Moshi -Kilimanjaro region has registered remarkable success in retaining HIV/AIDS patients on drugs and constant clinic attendance, resulting in more than 95 per cent of HIV-positive women bearing babies free from the problem. (Source: AllAfrica News: Pregnancy and Childbirth)
Nigeria: UNAIDS, Lancet Raise Alarm Over New HIV Epidemic
[Independent (Lagos)] Abuja -Unless countries worst affected by Humman Immuno Virus (HIV) demonstrate determination and focus on stopping new HIV infection and increasing access to anti-retroviral drugs, the epidemic would definitely rebound. (Source: AllAfrica News: HIV-Aids and STDs)
Medical News Today: HIV risk 'reduced by longer secondary schooling'
Researchers estimates pupils receiving an extra year of secondary school had an 8 percentage point lower risk of HIV infection a decade later than those that did not. (Source: Health News from Medical News Today)
Cryptosporidiosis: Facts, Treatment & Prevention
Cryptosporidiosis or, 'crypto,' is a form of disease that causes a person to experience watery diarrhea. It is caused by microscopic germs; parasites called, 'Cryptosporidium.' While crypto may affect anyone, some groups are likely to develop more serious illness. For those with weakened immune systems, symptoms may be severe and might lead to life-threatening illness. Examples of people with weakened immune systems include people with AIDS, people with inherited forms of diseases that affect their immune system, as well as transplant and cancer patients who are taking certain immunosuppressive medications. (Source: Disabled World)
Reproductive desires of men and women living with HIV: Implications for family planning counselling
Publication date: Available online 16 June 2015 Source:Reproductive BioMedicine Online Author(s): Cornelia van Zyl , Maretha J. Visser The reproductive desires of people living with HIV/AIDS (PLHIV) of low socioeconomic standing attending public health facilities in South Africa were studied. HIV-positive men, pregnant and non-pregnant women were recruited from two clinics at a large public hospital in Tshwane, South Africa. Individual interviews were used to explore the reproductive desires of HIV-positive participants. HIV counsellors' perceptions of their clients' reproductive desires were explored during focus group discussions. Parenthood proved to be an important factor to all participants in continuation of the family and establishing their gender identities, despite the possible ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Bisexual Behaviors, HIV Knowledge, and Stigmatizing/Discriminatory Attitudes among Men Who Have Sex with Men
by Meizhen Liao, Mei Wang, Xingjie Shen, Pengxiang Huang, Xingguang Yang, Lianzheng Hao, Catherine Cox, Pingsheng Wu, Xiaorun Tao, Dianmin Kang, Yujiang Jia Objective To assess the correlates for bisexual behaviors, HIV knowledge, and HIV/AIDS-related stigmatizing/discriminatory attitudes among men who have sex with men (MSM). Methods A cross-sectional survey among MSM was conducted in 2011 to provide demographics, sexual behaviors, HIV knowledge, HIV/AIDS-related stigmatizing/discriminatory attitudes, and services in Jinan, Qingdao, and Yantai of Shandong Province of China. Results Of 1230 participants, 82.8% were single, 85.7% aged (Source: PLoS One)
Length of secondary schooling and risk of HIV infection in Botswana: evidence from a natural experiment
Publication date: Available online 28 June 2015 Source:The Lancet Global Health Author(s): Jan-Walter De Neve , Günther Fink , S V Subramanian , Sikhulile Moyo , Jacob Bor Background An estimated 2·1 million individuals are newly infected with HIV every year. Cross-sectional and longitudinal studies have reported conflicting evidence for the association between education and HIV risk, and no randomised trial has identified a causal effect for education on HIV incidence. We aimed to use a policy reform in secondary schooling in Botswana to identify the causal effect of length of schooling on new HIV infection. Methods Data for HIV biomarkers and demographics were obtained from the nationally representative household 2004 and 2008 Botswana AIDS Impact Surveys (N=7018). In 1996, Botswana...
Why Send Humans To Space When We Can Send Robots?
We live in an exciting era. For the first time in half a century, we are embroiled in another great space race. With each passing day our understanding of ourselves and our universe allows for massive innovations in the fields of science and technology, such as computers that are learning to program themselves or developing cures for medical scourges of humanity like cancer or AIDS. In the midst of these breakthroughs, it can be difficult to step back and approach such developments not only with a sense of wonder, but also with a critical eye. Perhaps the most crucial question of our times is: ?At what cost?? It?s a question which despite its importance is nevertheless asked far too infrequently. Going to space is great, of course. But what does it mean for the future of humanity whe...
A comparative study of erectile function and use of erectile aids in high-risk prostate cancer patients after robot-assisted laparoscopic prostatectomy
Scandinavian Journal of Urology, Ahead of Print. (Source: Scandinavian Journal of Urology)
Prevalence and Severity of Oral Diseases in the Africa and Middle East Region.
Authors: Abid A, Maatouk F, Berrezouga L, Azodo C, Uti O, El-Shamy H, Oginni A Abstract This review aims to determine the prevalence and severity of oral health diseases in the Africa and Middle East region (AMER). The profile of oral diseases is not homogeneous across the AMER. There are large disparities between groups. Reliable data are scarce. The prevalence and severity of oral diseases appear to be increasing in the African region, as does associated morbidity. There are substantial differences in inequalities in oral health. Dental caries prevalence is less severe in most African countries than in developed countries, but the high rate of untreated caries reflects the limited resources available and difficulties of access and affordability to essential oral health care servi...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
HIV infection in male adolescents: a qualitative study
This study demonstrates the importance of the formulation of public policies on sexual and reproductive health, which include adolescents and young men. These policies should embody the perspective of masculinity in all its widest aspects, as well as actions in favor of sexual diversity. (Source: Ciencia e Saude Coletiva)
A Painful Problem: The Importance of Mitigating Pain and Stress for Better Sleep
This article originally appeared on the Amerisleep blog. Rosie Osmun is the Creative Content Manager at Amerisleep, a progressive memory foam mattress brand focused on eco-friendly sleep solutions. Rosie writes more posts on the Amerisleep blog about the science of sleep, eco-friendly living, leading a healthy lifestyle and more. ___________________ Also on The Huffington Post: -- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website. (Source: Healthy Living - The Huffington Post)
Recent Study Outlines Car Crash Risk of Over-the-Counter Sleep Aids;...
Ayurveda Herbal Corp comments on a recent study showing increased risk of car crashes among people taking chemical sleep aids. A common spice found in every kitchen, on the other hand, provides...(PRWeb June 26, 2015)Read the full story at http://www.prweb.com/releases/2015/06/prweb12813165.htm (Source: PRWeb: Medical Pharmaceuticals)
The relation between dermoscopy and histopathology of basal cell carcinoma
CONCLUSIONS: Basal cell carcinomas show a wide spectrum of dermoscopic features. Arborizing vessels were the most common dermoscopic findings in Basal cell carcinomas, while superficial Basal cell carcinomas displayed mainly milky-pink to red areas, and arborizing microvessels. The most common dermoscopic features of pigmented types were islands of pigment (blue-gray globules, blue-gray ovoid nests). In conclusion, dermoscopy can be used as a valuable tool for the diagnosis of Basal cell carcinomas and prediction of their histopathological subtypes. (Source: Anais Brasileiros de Dermatologia)
[Editorial] Sustainable equality?a goal to aspire to
2015 marks a transition point for development which is, in its own way, exhilarating. The Millennium Development Goals (MDGs) will shortly expire, and these familiar and extensively discussed benchmarks can then be judged to have culminated in successes, failures, or opportunities against the extraordinary backdrop of the era?from the response to a catastrophic epidemic of HIV/AIDS to the profound and challenging global shifts in disease epidemiology, demography, and migration. A new set of aspirations must be fashioned to prepare the world's people for times of continuing, indeed perhaps intensifying, change and uncertainty. (Source: LANCET)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Impact of an interprofessional shared decision-making and goal-setting decision aid for patients with diabetes on decisional conflict ¿ study protocol for a randomized controlled trial
DiscussionAn individualized approach to patients with multiple chronic conditions using SDM and goal setting is a desirable strategy for achieving guideline-concordant treatment in a patient-centered fashion. Our pilot trial will provide insights regarding strategies for the routine implementation of such interventions in clinical practice, and it will offer an assessment of the impact of this approach.Trial registrationClinicaltrials.gov Identifier: NCT02379078. Date of Registration: 11 February 2015. (Source: BioMed Central)
An overview of antifungal peptides derived from insect
Publication date: Available online 18 June 2015 Source:Peptides Author(s): Mohammad Omer Faruck , Faridah Yusof , Silvia Chowdhury Fungi are not classified as plants or animals. They resemble plants in many ways but do not produce chlorophyll or make their own food photosynthetically like plants. Fungi are useful for the production of beer, bread, medicine, etc. More complex than viruses or bacteria; fungi can be destructive human pathogens responsible for various diseases in humans. Most people have a strong natural immunity against fungal infection. However, fungi can cause diseases when this immunity breaks down. In the last few years, fungal infection has increased strikingly and has been accompanied by a rise in the number of deaths of cancer patients, transplant recipients, and acq...
Population-based human immunodeficiency virus 1 drug resistance profiles among individuals who experienced virological failure to first-line antiretroviral therapy in Henan, China during 2010&#8211;2011
Conclusion: Multiple and complex patterns of HIV-1 drug resistance mutations were identified among individuals who experienced virological failure to first-line ART in Henan, China during 2010?2011. Therefore, timely virological monitoring, therapy adjustments, and more varieties of drugs and individualized treatment should be immediately considered in this patient population. (Source: AIDS Research and Therapy)
Race-Based Sexual Stereotypes and Their Effects on Sexual Risk Behavior in Racially Diverse Young Men Who Have Sex with Men.
Authors: Newcomb ME, Ryan DT, Garofalo R, Mustanski B Abstract Men who have sex with men (MSM) are disproportionately impacted by the HIV/AIDS epidemic in the United States. The epidemic is not evenly distributed across MSM, and young racial minority MSM experience the highest rate of new infections. Race-based sexual stereotyping is not uncommon among MSM, and it may contribute to the isolation of racial minority sexual networks, which has been found to contribute to increased HIV incidence in Black MSM. The goals of these analyses were to describe the race-based sexual preferences and stereotypes of racially diverse young MSM (YMSM), and to examine whether endorsement of sexual stereotypes was associated with sexual risk behavior when having sex with partners of the stereotyped r...
A new look at AIDS data, with an assist from Gilead
A map showing the prevalence of HIV/AIDS as closely as a census tract could help health care programs zero in on cities and even neighborhoods where they can focus their HIV treatment and prevention efforts. AIDSVu is a project of Emory University's Rollins School of Public Health in Atlanta in partnership with Gilead Sciences Inc. (NASDAQ: GILD), the Foster City company that is the largest developer of HIV drugs. It recently relaunched its website with the most-recently available national data? (Source: bizjournals.com Health Care:Physician Practices headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
How Sheryl Lee Ralph Plans To Make More People Aware Of Their HIV Status
Saturday marks the 20th Anniversary of National HIV Testing Day and legendary actress Sheryl Lee Ralph is helping to raise awareness by encouraging Americans to get tested. Ralph?s commitment to the cause prompted the 1990 launch of her nonprofit, Divinely Inspired Victoriously Aware (D.I.V.A.) Foundation, which works to lower the infection rates of HIV/AIDS through testing, erase stigma and develop programs to combat the disease. In recent years tests like the OraQuick in-home HIV test have made testing easier than ever -- providing a safe, effective and confidential in-home testing option, you can learn your results in as few as 20 minutes. During an interview with The Huffington Post, Ralph explained the importance -- especially within the black community -- of knowing one?s status...
Dear Colleague: National HIV Testing Day (NHDTD)
June 27, 2015 is National HIV Testing Day, which reinforces and promotes the importance of HIV testing to increase the number of people who are aware of their HIV status. (Source: CDC HIV/AIDS Prevention)
Identifying New Positives and Linkage to HIV Medical Care ? 23 Testing Site Types, United States, 2013
Among the estimated 1.2 million persons living with human immunodeficiency virus (HIV) infection in the United States, approximately 14% have not had their HIV diagnosed (Source: CDC HIV/AIDS Prevention)
Prevalence of Diagnosed and Undiagnosed HIV Infection ? United States, 2008?2012
Persons unaware of their human immunodeficiency virus (HIV) infection contribute nearly one third of ongoing transmission in the United States (Source: CDC HIV/AIDS Prevention)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Namibia: No Prophet Can Cure Aids - Haufiku
[Namibian] HEALTH and social services minister Bernard Haufiku has urged the community to stay away from "self-styled prophets and healers" who claim that they can cure HIV-AIDS. (Source: AllAfrica News: Health and Medicine)
Namibia: Health Minister Warns Against False Prophets
[New Era] Minister of Health and Social Services Dr Bernard Haufiku says individuals who claim they can cure HIV/AIDS are self-proclaimed prophets. (Source: AllAfrica News: Health and Medicine)
South Sudan: New UN Study Calls for Boosted Aids Treatment Efforts Amid Threat of Viral Resurgence Featured
[Ethiopian Herald] In Malakal, South Sudan, an HIV support network with around 150 members meet on a regular basis to talk about the challenges faced in accessing antiretroviral medicines. Photo: UNAIDS (Source: AllAfrica News: HIV-Aids and STDs)
Africa: World Must Drastically Accelerate Aids Efforts or Face More HIV Infections and Deaths Than Five Years Ago--Says UNAIDS and Lancet Commission
[UNAIDS] London -New report 'Defeating AIDS-Advancing global health' shows that innovations in the AIDS response should be exploited to meet future global health challenges. (Source: AllAfrica News: Health and Medicine)
Africa: Partnership Forum Looks At Strategy to End Epidemics
[Global Fund] Bangkok -Consultations began today among partners in global health, including civil society, nongovernmental organizations and public health experts, seeking input into a new strategy to accelerate the end of AIDS, tuberculosis and malaria as epidemics and build resilient and sustainable systems for health. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Medical News Today: Global AIDS efforts must improve or infections and deaths will increase
A new report states that unless efforts to stop new HIV infections and improve access to treatment improve over the next 5 years, deaths from AIDS and HIV infections will increase. (Source: Health News from Medical News Today)
Relapse Secondary to Medication Access Issue
A 24-year-old woman with a history of AIDS and diffuse B-cell lymphoma, actively being treated with chemotherapy, was admitted with diarrhea and abdominal pain. Her stool sample was positive for Clostridium difficile toxin. Because the patient had prior episodes of C difficile?associated diarrhea (CDAD), she was treated with oral vancomycin and discharged with a prescription for 14 days of oral vancomycin. The patient took her prescription to her pharmacy, but was informed that the oral vancomycin solution had not been approved by her insurance. (Source: AORN Journal)
NIDA announces new awards for early stage investigators
(NIH/National Institute on Drug Abuse) The National Institute on Drug Abuse today announced the first six recipients of its two newly developed Avenir Award programs for HIV/AIDS and genetics or epigenetics research. (Source: EurekAlert! - Medicine and Health)
Poszczepienne gru?licze zapalenie ucha ?rodkowego i jego powik?ania ? opis przypadku
Conclusion This case reminds us that correct diagnosis of tuberculosis remains a serious problem despite the long experience and the development of diagnostics and treatment methods. Nowadays we observe the unusual clinical manifestations of the disease (e.g. such as ear pain, tinnitus, rapid hearing loss) more frequently. (Source: Otolaryngologia Polska)
Expanded Cytotoxic T-cell Lymphocytes Target the Latent HIV Reservoir
Enhanced human immunodeficiency virus (HIV)-specific immunity may be required for HIV eradication. Administration of autologous, ex vivo expanded, virus-specific, cytotoxic T-lymphocytes derived from HIV-infected patients on suppressive antiretroviral therapy (HXTCs) are a powerful tool for proof-of-concept studies. Broadly specific, polyclonal HXTCs resulting from ex vivo expansion demonstrated improved control of autologous reservoir virus compared to bulk CD8+ T cells in viral inhibition assays. Furthermore, patient-derived HXTCs were able to clear latently infected autologous resting CD4+ T cells following exposure to the latency-reversing agent, vorinostat. HXTCs will be ideal reagents to administer with precise control in future in vivo studies in combination with latency-reversing a...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Diminished Impact of Ethnicity as a Risk Factor for Chronic Kidney Disease in the Current HIV Treatment Era
Conclusions.&nbsp;Among HIV-infected patients in the Netherlands, being of SSA origin was associated with a higher baseline CKD prevalence but had no impact on newly developing CKD over time. This suggests a shift in the etiology of CKD from HIV-associated nephropathy toward other etiologies. (Source: The Journal of Infectious Diseases)
The readiness of the national health laboratory system in supporting care and treatment of HIV/AIDS in Tanzania
Conclusion: Tanzania has a well established national health laboratory network sufficient to support HIV care and treatment services. However, laboratories at the primary health care level are constrained by inadequate resources and operate within a limited capacity. Improving the laboratory capacity in terms of number of qualified personnel, staff training on the national guidelines, laboratory diagnostic tools and coordination should be given a higher priority. (Source: BMC Health Services Research)
contributions of attention and elaboration to associative encoding in young and older adults
Publication date: Available online 23 June 2015 Source:Neuropsychologia Author(s): Siri-Maria Kamp , Hubert D. Zimmer Episodic memory declines during healthy aging, with a particular reduction in the ability to encode associations. We investigated the role of alternating attentional focus between two items of a pair in order to generate associative links, as well as working memory based elaborative processes in this age-related memory deficit. While their eye gaze behavior and ERPs were recorded, 19 young and 22 elderly (64-79 years) participants used interactive imagery to encode pairs of spatially separated objects. In a subsequent recognition test, older adults showed a larger reduction in associative- than item memory, relative to young adults. For both age groups the number of eye g...
Major recurrent aphthous stomatitis in mother and son with HIV/AIDS infection ? Case report
The objective of this paper is to report a case of two patients (mother and son) with HIV infection and simultaneously presenting major recurrent aphthous stomatitis. (Source: Pediatria Polska)
Mano a Mano for Health Professions Students in Chile: A Pilot HIV Prevention Program
HIV is cause for major concern all over the globe. By the end of 2009, there were 33.3 million reported cases of people living with HIV (PLWH) worldwide, with 2.6 million new infections and 1.8 million HIV-related deaths (Joint United Nations Program on HIV/AIDS [UNAIDS], 2010). Specifically in Latin America, the incidence of HIV has increased from 1.1 million adults and children living with HIV in 2001 to 1.4 million adults and children living with HIV in 2009 (UNAIDS, 2010). Additionally, the rate of new infections has grown, as there were 150,000 reported cases of new infections in 2001 and this number increased to 170,000 reported cases of new infections in 2008. (Source: Journal of the Association of Nurses in AIDS Care)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Progress Seen in HIV Diagnosis
(MedPage Today) -- Analysis suggests several states meeting HIV/AIDS target for identifying people with virus (Source: MedPage Today OB/GYN)
Structural Determinants of Client Perpetrated Violence Among Female Sex Workers in Two Mexico-U.S. Border Cities
Abstract Female sex workers (FSWs) are disproportionately affected by both HIV and gender-based violence, such as that perpetrated by clients (CPV). We used a structural determinants framework to assess correlates of physical or sexual CPV in the past 6 months among FSWs in the Mexico/U.S. border cities of Ciudad Juárez and Tijuana. Bivariate and multivariate logistic regression analysis identified individual, client, interpersonal, work environment and macrostructural factors associated with recent CPV. Among 496 FSWs, 5 % experienced recent CPV. Witnessing violence towards other FSWs in one?s neighborhood (aOR 5.6, 95 % CI 1.8?17.2), having a majority of foreign (aOR 3.5, 95 % CI 1.4?8.4) or substance using (aOR 4.0, 95 % CI 1.5?10.4) clients, and being a street wo...
Thrombocytopenia and cancer risk during HIV infection
No abstract available (Source: AIDS)
Thrombocytopenia and risk of cancer during treated HIV disease
No abstract available (Source: AIDS)
HIV+ patient on suppressive antiretroviral therapy with steroid injection-induced myopathy
No abstract available (Source: AIDS)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Multiple co-circulating HIV-1 subtypes in the Middle East and North Africa
HIV-1 incidence has been increasing more rapidly in the Middle East and North Africa than in any other global region. Despite this trend, HIV epidemiology in the region remains poorly defined. We conducted an analysis of 3284 publicly available HIV-1 sequences from 15 countries in the Middle East and North Africa to better characterize the regional epidemic. A phylogenetic tree based on the reverse transcriptase gene revealed a complex mosaic of diverse HIV subtypes and circulating recombinant forms across the region. (Source: AIDS)
Observations on home HIV testing
No abstract available (Source: AIDS)
Examining the association between male circumcision and sexual function: evidence from a British probability survey
Conclusion: Data from a large, nationally representative British survey suggest that circumcision is not associated with men's overall sexual function at a population level. (Source: AIDS)
Rates of HIV testing and diagnosis in South Africa: successes and challenges
Background: UNAIDS aims for 90% of HIV-positive individuals to be diagnosed by 2020, but few attempts have been made in developing countries to estimate the fraction of the HIV-positive population that has been diagnosed. Methods: To estimate the rate of HIV diagnosis in South Africa, reported numbers of HIV tests performed in the South African public and private health sectors were aggregated, and estimates of HIV prevalence in individuals tested for HIV were combined. The data were integrated into a mathematical model of the South African HIV epidemic, which was additionally calibrated to estimates of the fraction of the population ever tested for HIV, as reported in three national household surveys. Results: The fraction of HIV-positive adults who were undiagnosed declined from more tha...
Tuberculosis incidence rate and risk factors among HIV-infected adults with access to antiretroviral therapy
Conclusion: In TB endemic regions, HIV-infected patients initiating ART, particularly men and those with poor nutritional status, should be closely monitored for active TB at ART initiation. In addition to increasing the access to ART, interventions should be considered to improve nutritional status among HIV-infected patients. (Source: AIDS)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Expanded HIV testing coverage is associated with decreases in late HIV diagnoses
Conclusion: Increases in recent HIV testing coverage may have reduced late HIV diagnoses among men. Persistent geographic disparities underscore the need for continued expansion of HIV testing to promote earlier HIV diagnosis. (Source: AIDS)
HIV resistance testing and detected drug resistance in Europe
Objectives: To describe regional differences and trends in resistance testing among individuals experiencing virological failure and the prevalence of detected resistance among those individuals who had a genotypic resistance test done following virological failure. Design: Multinational cohort study. Methods: Individuals in EuroSIDA with virological failure (>1 RNA measurement >500 on ART after >6 months on ART) after 1997 were included. Adjusted odds ratios (aORs) for resistance testing following virological failure and aORs for the detection of resistance among those who had a test were calculated using logistic regression with generalized estimating equations. Results: Compared to 74.2% of ART-experienced individuals in 1997, only 5.1% showed evidence of virological failure in 2012. Th...
CD4+ cell count responses to antiretroviral therapy are not impaired in HIV-infected individuals with tuberculosis co-infection
Conclusions: Long-term CD4+ cell recovery during ART appears similar in HIV-TB and TB-free patients. Significant mortality in both cohorts highlights the need for earlier HIV diagnosis and ART initiation. (Source: AIDS)
The effect of short-course antiretroviral therapy initiated in primary HIV-1 infection on interleukin-6 and D-dimer levels
Objective: Interruption of antiretroviral therapy (ART) in chronic HIV disease is associated with increased mortality, predicted by elevations in interleukin-6 (IL-6) and D-dimer. The effect of ART interruption in primary HIV-1 infection on these biomarkers is unknown. Methods: Plasma samples from 200 HIV seroconverters enrolled in the Short Pulse Anti-Retroviral Therapy At HIV Seroconversion trial of deferred ART (standard of care) ? 12 or 48 week ART (ART12 or ART48, respectively) ? were analysed for IL-6 and D-dimer at weeks 0, 12, 16, 48, 52, 60 and 108 after randomization. Changes in log10 levels from weeks 0 to 12 were analysed using linear regression, as were changes from baseline to 4 weeks after stopping ART. Areas under the biomarker?time curves (AUC) to week 108 were adjus...
Immunogenicity and safety of the 13-valent pneumococcal conjugate vaccine in HIV-infected individuals naive to pneumococcal vaccination
Conclusion: A three-dose regimen of PCV13 was well tolerated in pneumococcal vaccine-naive, HIV-infected individuals. Significant immune responses to all serotypes were observed following the first dose of PCV13, with only modest increases in antibody titres following subsequent PCV13 or PPSV23 administration. (Source: AIDS)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
HIV infection results in ventral?striatal reward system hypo-activation during cue processing
Conclusion: HIV caused a decrease in activity during cue processing in the ventral striatum, with normal cortical functioning during reward outcome processing. Our results therefore suggest that HIV not only has an impact on fronto-striatal systems involved in executive functioning, but also has a direct impact on the function of the ventral?striatal reward system. (Source: AIDS)
Association of HIV, hepatitis C virus and liver fibrosis severity with interleukin-6 and C-reactive protein levels
Conclusion: Liver fibrosis severity is associated with greater IL-6 levels, but the stimulatory effect of IL-6 on CRP appears to be blunted by HCV replication rather than by liver fibrosis severity. Investigation of the potential CRP rebound after HCV-RNA eradication and persistent liver fibrosis on organ injury is needed. (Source: AIDS)
Comparing genotoxic signatures in cord blood cells from neonates exposed in utero to zidovudine or tenofovir
The objective of the present study was to assess the genotoxic effects of either zidovudine or tenofovir-based combination therapies on cord blood cells in newborns exposed in utero. Design: We compared the aneuploid rate and the gene expression profiles in cord blood samples from newborns exposed either to zidovudine or tenofovir-based combination therapies during pregnancy and from unexposed controls (n?=?8, 9, and 8, respectively). Methods: The aneuploidy rate was measured on the cord blood T-cell karyotype. Gene expression profiles of cord blood T cells and hematopoietic stem and progenitor cells were determined with microarrays, analyzed in a gene set enrichment analysis and confirmed by real-time quantitative PCRs. Results: Aneuploidy was more frequent in the zidovudine-exposed g...
Detection of HIV-1-specific T-cell immune responses in highly HIV-exposed uninfected individuals by in-vitro dendritic cell co-culture
Conclusions: The combined use of our boosted dendritic cell technique with a boosted flow cytometric approach allows us both to detect specific HIV-positive responses in a higher percentage of HESN patients and to define specific effector function profiles. This study contributes to a better understanding of resistance to HIV infection. (Source: AIDS)
Activated platelet?T-cell conjugates in peripheral blood of patients with HIV infection: coupling coagulation/inflammation and T cells
Conclusion: These data support a model in which platelet?T-cell conjugates may play a critical role in the fast recruitment of antigen-experienced T cells to the place of injury. This mechanism can contribute in maintaining a state of coagulation/inflammation observed in these patients contributing to the pathology of the disease. (Source: AIDS)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Defining success with HIV pre-exposure prophylaxis: a prevention-effective adherence paradigm
No abstract available (Source: AIDS)
Soluble CD40 ligand contributes to dendritic cell-mediated T-cell dysfunction in HIV-1 infection
Conclusion: Elevated sCD40L during HIV infection impairs dendritic cell function, contributing to innate and adaptive immune dysfunction. Antiretroviral adjunctive therapies that decrease sCD40L may provide immune modulatory benefits. (Source: AIDS)
New study suggests resistance testing may not be best use of resources for HIV treatment programmes in low-income settings
No abstract available (Source: AIDS)
Differential diagnosis of diffuse alveolar haemorrhage in immunocompromised patients
Purpose of review: Diffuse alveolar haemorrhage (DAH) is a life-threatening medical emergency in immunocompromised and immunocompetent patients characterized by haemoptysis, anaemia, acute respiratory failure and diffuse pulmonary infiltrates on radiologic examination. This review describes DAH imaging features, causes and main differential diagnosis. Recent findings: In immunosuppressed patients, DAH occurs most frequently in haematologic neoplasms, after haematopoietic stem cell transplantation or solid organ transplantation, secondary to drug reaction or infection, and associated with AIDS. However, differential diagnoses of all of these conditions include several conditions with similar findings. Summary: Imaging patterns of DAH do not differ significantly from those of conditions incl...
Sequence of Shots May Lead to Effective HIV Vaccine, Mouse Study Finds
Series of immunizations might encourage HIV-fighting antibodies Source: HealthDay Related MedlinePlus Pages: HIV/AIDS, Immunization (Source: MedlinePlus Health News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Is It Bedtime for Benzos?
?Bernard also laughed; after two grams of soma the joke seemed, for some reason, good. Laughed and then, almost immediately, dropped off to sleep.? ? Aldous Huxley, Brave New World It?s been a tough few years for benzodiazepines, the pharmaceutical industry?s top-selling family of prescription drugs. Tough in every way, that is, except sales: Xanax remains the world?s most popular pill, and U.S. prescriptions for it and other benzos grow by 12 percent every year. It?s their reputation, long enjoyed, as harmless and effective medicines that?s taking a flurry of hits ? some glancing, others on the nose. For starters, researchers have recently posited a link between benzos and Alzheimer?s; they?ve documented an explosion in overdoses and ER visits by people mixing benzo...
Africa: Call for Boosted Aids Treatment Amid Threat of Viral Resurgence
[UN News] The world risks a deadly AIDS rebound unless the countries most affected by the virus expand access to antiretroviral treatments and boost their focus on stopping new infections, a new United Nations report has warned. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: UNAIDS and Lancet Commission Call for Urgent Action On Aids Response
[Global Fund] Countries most affected by HIV must focus on stopping new HIV infections and expanding access to antiretroviral treatment or risk the epidemic rebounding, urges a major new report from the UNAIDS and Lancet Commission. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: Voices At the Partnership Forum 2015
[Global Fund] Consultations began today in Bangkok, Thailand, among partners in global health, including civil society, nongovernmental organizations and public health experts, seeking input into a new strategy to accelerate the end of AIDS, tuberculosis and malaria as epidemics and build resilient and sustainable systems for health. (Source: AllAfrica News: HIV-Aids and STDs)
HIV epidemic will rebound dramatically without more funding, warn experts
Analysis by UNAids and Lancet Commission highlights ?fragile window of opportunity? to maintain progress on curbing deaths and infectionsThe world could see the HIV epidemic rebound dramatically if countries fail to increase funding and expand access to drugs in the next five years, according to a major report. The analysis, by the UNAids and Lancet Commission, highlights a ?fragile window of opportunity? for maintaining progress on curbing deaths and infections and suggests that progress made during the past decade could easily be reversed. Continue reading... (Source: Guardian Unlimited Science)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Southern Africa: Civil Society Organisations Review Country's Human Rights Record for the Universal Periodic Review
[SALC] The Southern Africa Litigation Centre (SALC), Legal Assistance Centre (LAC), Namibia Women's Health Network (NWHN), Women's Leadership Centre (WLC) and the Southern Africa Christian Initiative (SACHI) have commended Namibia for positive developments in the area of human rights since 2011, while at the same time calling on authorities to strengthen their efforts towards the protection and promotion of human rights in the country. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: Churches Need to Do More to Tackle HIV and Aids
[WCC] "HIV and AIDS is not just a challenge for governments but for all segments of society, including churches. In many African countries churches are an authority that people listen to - it is therefore crucial that churches help eliminate the pandemic," said Rev. Dr Luciano Chanhelela Chianeque in an interview conducted with the WCC News. (Source: AllAfrica News: HIV-Aids and STDs)
Lipodystrophy among HIV-infected patients: a cross-sectional study on impact on quality of life and mental health disorders.
CONCLUSIONS: LD, depression and anxiety were frequent features among HIV-infected individuals seen in the metabolic clinic and significantly impacted on their quality of life. PMID: 26097493 [PubMed] (Source: AIDS Research and Therapy)
New UN study calls for major surge in AIDS treatment to avoid 'catastrophic' resurgence of HIV
The world risks a deadly AIDS rebound unless the countries most affected by the virus expand access to antiretroviral treatments and boost their focus on stopping new infections, a new United Nations report has warned. (Source: UN News Centre - Health, Poverty, Food Security)
Zimbabwe: Zim to Start HIV Vaccine Trials
[The Herald] Zimbabweans may soon be immunised against HIV transmission if trials for a vaccine to prevent the spread of the deadly virus expected to start in the near future are successful. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Drug arrests connected to Indiana HIV outbreak
Prescription painkiller abuse has helped fuel the spread of the virus that causes AIDS (Source: Health News: CBSNews.com)
Genital Inflammation and the Risk of HIV Acquisition in Women
Conclusions.&nbsp;Elevated genital concentrations of HIV target cell&ndash;recruiting chemokines and a genital inflammatory profile contributes to the high risk of HIV acquisition in these African women. (Source: Clinical Infectious Diseases)
In Utero Exposure to Zidovudine and Heart Anomalies in the ANRS French Perinatal Cohort and the Nested PRIMEVA Randomized Trial
Conclusions.&nbsp;This study confirms a specific association between in utero exposure to ZDV and CHDs, and a long-lasting postnatal myocardial remodeling in girls. A potential common mechanism, including the involvement of mitochondrial dysfunction, must be explored, and long-term consequences on cardiac function warrant specific attention. Clinical Trials Registration.&nbsp;NCT00424814. (Source: Clinical Infectious Diseases)
The High Risk of an HIV Diagnosis Following a Diagnosis of Syphilis: A Population-level Analysis of New York City Men
Conclusions.&nbsp;HIV incidence among men diagnosed with syphilis is high; one in 20 MSM were diagnosed with HIV within a year. Our data have implications for syphilis and HIV screening and may be useful for further targeting HIV-negative populations for pre-exposure prophylaxis. (Source: Clinical Infectious Diseases)
Editorial Commentary: Uncoupling Epidemiological Synergy: New Opportunities for HIV Prevention for Men Who Have Sex With Men
(Source: Clinical Infectious Diseases)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
AIDS and global health: the path to sustainable development
Publication date: Available online 24 June 2015 Source:The Lancet Author(s): Selina Lo , Richard Horton (Source: The Lancet)
The sustainable development agenda and the end of AIDS
Publication date: Available online 24 June 2015 Source:The Lancet Author(s): Michel Sidibé (Source: The Lancet)
Michel Sidibé: working to end AIDS as a public health threat
Publication date: Available online 24 June 2015 Source:The Lancet Author(s): Sarah Boseley (Source: The Lancet)
Multiparametric Sonography of Testicular Hematomas: Features on Grayscale, Color Doppler, and Contrast-Enhanced Sonography and Strain Elastography
We investigated the appearances of intratesticular hematomas on multiparametric sonography combining grayscale, color Doppler, and contrast-enhanced sonography and strain elastography. Over a 3-year period, 17 hematomas in 8 patients were analyzed. Blunt trauma (n = 7) and surgery (n = 1) were preceding events. Grayscale sonography showed well-defined oval or round predominantly hypoechoic and heterogeneous, peripherally (n = 13) or centrally (n = 4) located lesions. Three showed contrast enhancement of septations, and 4 showed peripheral lesion rim enhancement. On strain elastography, the mean strain ratio was 1.19 (range, 0.41&ndash;2.36), and elasticity score were 3 or lower (n = 13) and 5 (n = 4). Multiparametric sonography shows nonenhancement with contrast and predominantly "soft" el...
Tuberculosis: A disease without boundaries
Tuberculosis (TB) is an airborne disease caused by Mycobacterium tuberculosis (MTB) that usually affects the lungs leading to severe coughing, fever, and chest pains. Although current research in the past four years has provided valuable insight into TB transmission, diagnosis, and treatment, much remains to be discovered to effectively decrease the incidence of and eventually eradicate TB. The disease still puts a strain on public health, being only second to HIV/AIDS in causing high mortality rates. (Source: Tuberculosis)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Gamma crystallins of the human eye lens.
CONCLUSIONS: There are several 'crucial' residues in and around the Greek key motifs which are essential to maintain the compact architecture of the crystallin molecules. We find that a mutation that replaces even one of these residues can lead to reduction in solubility, formation of light-scattering particles and loss of transparency in the molecular assembly. GENERAL SIGNIFICANCE: Such a molecular understanding of the process helps us construct the continuum of genotype-molecular structural phenotype-clinical (pathological) phenotype. PMID: 26116913 [PubMed - as supplied by publisher] (Source: Biochimica et Biophysica Acta)
Drastic acceleration of HIV fight needed to stop AIDS resurgence
LONDON, (Reuters) - The global HIV epidemic could see a resurgence in just five years without a drastic acceleration in efforts to prevent and treat the AIDS virus, the United Nations and disease experts said on Thursday. (Source: Reuters: Health)
Couples Are Getting Paid To Have Sex To Try And Curb Spread Of HIV
We're inching closer to getting a condom that's actually enjoyable to wear. The Guardian reported earlier this month on some of the lucky couples that are being paid by research-and-design teams to take new condom prototypes out for a test drive. "It slips in and out," one tester told the Guardian of an unfortunate romp using a female condom. "It leaves an unsightly baggy ring outside you. There is nothing erotic about it.? The testing is connected to the Bill and Melinda Gates Foundation?s challenge, announced about a year and a half ago, for scientists and designers to come together to create a "next generation condom." The hope is that more people would want to wear a new, better condom, which could lead to a reduction in the spread of HIV and other sexually transmitted diseases. Am...
Why Getting Tested For HIV Could Help Your Whole Community
One of the biggest misconceptions about the AIDS epidemic in the United States is that it's over. This belief is also part of why the disease is so dangerous -- and why campaigns like this week's National HIV Testing Week are so necessary. Nationally, 1.2 million Americans live with HIV or AIDS and about 50,000 more are diagnosed with HIV each year. But for a more complete view of the virus' impact, localized data is telling. Philadelphia has a citywide HIV infection rate that's five times the U.S. national average, and the infection rate in one of the city's southwestern neighborhoods is comparable to rates in Sierra Leone and Ghana. A full two-thirds of new HIV infections occur in just 3 percent of U.S. counties, according to newly released statistics from AIDSVu, a data project develop...
Africa: Africa - Aids Struggle Continues
[AfricaFocus] "Both globally and in Africa, there is good news. Our collective efforts to end the AIDS epidemic are paying off. Now more people living with HIV than ever before are accessing treatment, more people know their status, and AIDS-related deaths are declining. ... This progress, however, belies a dangerous reality: young African women and adolescent girls are especially vulnerable to HIV." - UNAIDS, June 2015 (Source: AllAfrica News: Health and Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Tanzania: 40 People to Scale Mt Kilimanjaro
[Daily News] FORTY people will climb Mount Kilimanjaro on July 14, this year, in an initiative dubbed GGM Kili Challenge, geared towards raising awareness on the HIV/AIDS pandemic. (Source: AllAfrica News: Health and Medicine)
Nigeria: NPA Cautions Port Users Against HIV/Aids Spread
[Guardian] THE Nigerian Ports Authority (NPA) in collaboration with the Abidjan -Lagos Corridor (ALCO) has commenced its sensitization campaign on prevention of Human Immune Deficiency Virus and Acquired Immune Deficiency Syndrome (HIV/ AIDS) for ports users and truck drivers. (Source: AllAfrica News: HIV-Aids and STDs)
Zimbabwe: Another Mega Event for Zim
[The Herald] Zimbabwe will host this year's edition of the International Conference on AIDS and STIs in Africa (ICASA) following a successful assessment on the country's capability to host the continent's largest Aids gathering. (Source: AllAfrica News: HIV-Aids and STDs)
Botswana: Govt Should Respect Court Orders - Dingake
[Botswana Daily News] Gaborone -Justice Key Dingake of Gaborone High Court says he agrees with jurisdictions, which hold the view that government should lead by example by obeying orders. (Source: AllAfrica News: HIV-Aids and STDs)
America's third-world government dumps fluoride in drinking water while Ethiopia seeks to remove toxin from water to protect public health
(NaturalNews) It's a prolific disease that's ravaging some areas of Africa and causing permanent health damage among residents. No, we're not talking about malaria or AIDS -- fluorosis, a health condition triggered by exposure to fluoride, is damaging people's teeth and skeletal structures... (Source: NaturalNews.com)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Norepinephrine aids brain in sorting complex auditory signals
(University of Massachusetts at Amherst) In the Journal of Neuroscience this week, doctoral student Maaya Ikeda and her advisor, neuroscientist Luke Remage-Healey at the University of Massachusetts Amherst, report finding that the neuromodulator norepinephrine has an unexpected, direct action on auditory processing of complex signals, specifically bird songs in the zebra finch. (Source: EurekAlert! - Biology)
Symptoms of Psychopathology in Hearing-Impaired Children
Conclusions: Children who are deaf or profoundly hearing impaired and have cochlear implants have lower levels of psychopathological symptoms than children with moderate or severe hearing loss who have hearing aids. Most likely, it is not the type of hearing device but rather the intensity of the rehabilitation program that can account for this difference. This outcome has major consequences for the next generation of children with hearing loss because children with profound hearing impairment still have the potential to have levels of psychopathology that are comparable to children who are normally hearing. (Source: Ear and Hearing)
Effects of a Dual Sensory Loss Protocol on Hearing Aid Outcomes: A Randomized Controlled Trial
Conclusions: Although the per-protocol and subgroup analyses need to be interpreted with caution, DSL patients who experience HA difficulties could benefit from the DSL protocol by making better use of their HAs. The increasing prevalence and impact of DSL on a person?s independence and social participation call for more awareness of concurrent sensory impairments in both low vision and audiology rehabilitation. Interdisciplinary training for rehabilitation professionals could be an important step, followed by integration of vision and hearing services using the DSL protocol. (Source: Ear and Hearing)
Consensus on Hearing Aid Candidature and Fitting for Mild Hearing Loss, With and Without Tinnitus: Delphi Review
Objectives: In many countries including the United Kingdom, hearing aids are a first line of audiologic intervention for many people with tinnitus and aidable hearing loss. Nevertheless, there is a lack of high quality evidence to support that they are of benefit for tinnitus, and wide variability in their use in clinical practice especially for people with mild hearing loss. The aim of this study was to identify a consensus among a sample of UK clinicians on the criteria for hearing aid candidature and clinical practice in fitting hearing aids specifically for mild hearing loss with and without tinnitus. This will allow professionals to establish clinical benchmarks and to gauge their practice with that used elsewhere. Design: The Delphi technique, a systematic methodology that seeks cons...
Diagnostic accuracy of algorithms to identify hepatitis C status, AIDS status, alcohol consumption and illicit drug use among patients living with HIV in an administrative healthcare database
ConclusionsSensitivity was low to detect AIDS, alcohol abuse, illicit drug use and especially hepatitis C in RAMQ. Researchers must be aware of the potential for residual confounding and must consider additional methods to control for confounding. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Retention in care prior to antiretroviral treatment eligibility in sub-Saharan Africa: a systematic review of the literature
Conclusions Retention in HIV care prior to ART eligibility in sub-Saharan Africa has been insufficiently described so far leaving major research gaps, especially regarding long-term retention rates and sociodemographic, economic, clinical and programmatic logistic determinants. The prospective follow-up of newly diagnosed individuals is required to better evaluate attrition prior to ART eligibility among HIV-infected people. (Source: BMJ Open)
Video decision aids to assist with advance care planning: a systematic review and meta-analysis
Conclusions Video decision aids may improve some ACP-related outcomes. Before recommending their use in clinical practice, more evidence is needed to confirm these findings and to evaluate the impact of video decision aids when integrated into patient care. (Source: BMJ Open)
Modified Release Biodegradable Polymeric Microspheres of Stavudine: Cell Viability, Cellular Uptake, Hemolysis Studies and In vivo Pharmacokinetics.
Authors: Srivastava S, Kumar R, Arora SK, Sinha VR Abstract Family of retroviruses which replicate through the use of the reverse transcriptase enzyme or the enzyme needed to convert RNA to DNA for replication bears Human Immunodeficiency Virus (HIV). It causes irreversible destruction of the immune system leading to the occurrence of opportunistic infections and malignancies. The eradication of HIV is highly unlikely as the cells of the mononuclear phagocyte system (MPS) besides CD4 T lymphocytes are the specific hosts for HIV which needs to be targeted even after extended blood plasma profile of antiviral drug to maintain viral suppression and reduced disease progression. Aiming the current goal, biodegradable polymeric microspheres of PLGA 50:50 (RESOMER(®) 505H) were developed...
Evidence Supports Medical Pot for Some Conditions, Not Others
Review of 79 studies suggests states may have put cart before the horse, experts say (Source: The Doctors Lounge - Oncology)
Researchers identify new class of antifungal agents
A new class of antifungals has been identified, potentially useful to treat the more than 300 million people worldwide who develop serious fungal infections. Fungal infections are most commonly found in individuals with medical conditions that compromise the immune system, such as AIDS, or individuals who are being treated with immunosuppressives, such as those battling cancer. The three classes of antifungal drugs currently available--azoles, polyenes, and echinocandins--are far from optimal. (Source: ScienceDaily Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
HIV/AIDS Data through December 2012: Provided for the Ryan White HIV/AIDS Program, for Fiscal Year 2014
This surveillance supplemental report displays data used for funding allocations among various categories of grantees under the Ryan White HIV/AIDS Program for Fiscal Year 2014. (Source: CDC HIV/AIDS Prevention)
Zimbabwe: NAC Calls for More Aids Awarness Campaigns
[New Zimbabwe] NATIONAL AIDS Council (NAC) says community based organisations should be allowed to conduct HIV and AIDS awareness campaigns as this would help to reduce infections. (Source: AllAfrica News: Health and Medicine)
Botswana: Non-Communicable Diseases On Increase
[Botswana Daily News] Letlhakane -Minister of Health, Ms Dorcas Makgatho has urged Letlhakane residents to take responsibility of their health. (Source: AllAfrica News: HIV-Aids and STDs)
Zambia: Sexual, Reproductive Services Elude Youths
[Times of Zambia] It is said that health is wealth. But for the marginalised and vulnerable groups, access to health care services remains a pipedream if not a nightmare. (Source: AllAfrica News: HIV-Aids and STDs)
Zambia: CSO Sends Condoms Shortage Alert
[Zambia Reports] The Planned Parenthood Association has alerted the nation to the alleged shortage of condoms. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Reducing HIV Risks in the Places Where People Drink: Prevention Interventions in Alcohol Venues
Abstract Apart from individual alcohol drinking behavior, the context or places where people drink play a significant role in HIV transmission risk. In this paper, we review the research that has been conducted on alcohol venues to identify the social and structural factors (e.g., social norms, sexual behavior) that are associated with HIV risk in these places, to review HIV prevention interventions based in alcohol venues, and to discuss appropriate methodologies for alcohol venue research. Alcohol venues are defined here as places that sell or serve alcohol for onsite consumption, including bars, bottle stores, nightclubs, wine shops, and informal shebeens. Despite the many established HIV risk factors at play in alcohol venues, limited prevention strategies have been implemente...
National Vaccine Injury Compensation Program: addition of intussusception as injury for rotavirus vaccines to the vaccine injury table. Final rule.
Authors: Health Resources and Services Administration (HRSA), Department of Health and Human Services (HHS) Abstract On July 24, 2013, the Secretary of Health and Human Services (the Secretary) published in the Federal Register a Notice of Proposed Rulemaking (NPRM) proposing changes to the regulations governing the National Vaccine Injury Compensation Program (VICP). Specifically, the Secretary proposed revisions to the Vaccine Injury Table (Table). The basis for this change is consistent with the Secretary's findings that intussusceptions can reasonably be determined in some circumstances to be caused by rotavirus vaccines. The Secretary is now making this amendment to the Table and to the Qualifications and Aids to Interpretation (QAI), described below under Background Informati...
Effects of a quasi-randomized web-based intervention on risk behaviors and treatment seeking among HIV-positive men who have sex with men in Chengdu, China.
Authors: Mi G, Wu Z, Wang X, Shi CX, Yu F, Li T, Zhang L, McGoogan JM, Pang L, Xu J, Rou K Abstract The men who have sex with men (MSM) population in China has experienced a recent increase in HIV incidence . Due to the dual stigma and discrimination towards homosexuality and HIV infection, most MSM living with HIV/AIDS are hard to reach by offline intervention initiatives. We recruited HIV-positive MSM participants in Chengdu, China and assessed whether they disclosed their HIV status to partners, motivated a partner to receive testing, used condoms consistently, or initiated antiretroviral therapy. Participants were quasi-randomized to either the intervention or control arm. The intervention group was given instructions for an online program with four modules: an information exch...
Pivotal role of the genital epithelial cells in HIV-1 transmission.
Authors: De Saint Jean A, Bourlet T, Delezay O Abstract AIDS remains one of the world's most serious health challenges, with 35 million people living with HIV worldwide at the end of 2013. HIV sexual transmission accounts for the overwhelming majority of people newly infected, making genital and rectal mucosal tissues the major sites of infection. This review focuses on the role of the female genital epithelial cells in the establishment of HIV infection. PMID: 26105156 [PubMed - as supplied by publisher] (Source: Current HIV Research)
Mathematical Analysis of a Multiple Strain, Multi-locus-allele System for Antigenically Variable Infectious Diseases Revisited.
Authors: Cherif A Abstract Many important pathogens such as HIV/AIDS, influenza, malaria, dengue and meningitis generally exist in phenotypically distinct serotypes that compete for hosts. Models used to study these diseases appear as meta-population systems. Herein, we revisit one of the multiple strain models that have been used to investigate the dynamics of infectious diseases with co-circulating serotypes or strains, and provide analytical results underlying the numerical investigations. In particular, we establish the necessary conditions for the local asymptotic stability of the steady states and for the existence of oscillatory behaviours via Hopf bifurcation. In addition, we show that the existence of discrete antigenic forms among pathogens can either fully or partially s...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Ending HIV Transmission: What Babies Have Taught Us
Co-authored by Robert Grant Members of CDC's Elimination of Mother to Child Transmission of HIV Stakeholder's hold hands as a message of collaboration and solidarity. Recent advances in HIV science have brought a new bold possibility: Ending sexual HIV transmission. Both the city of San Francisco and New York State have launched ambitious "Getting to Zero" and "Ending HIV" initiatives that have served as cornerstones goals to significantly reduce HIV transmission. Other cities and states are discussing their own local initiatives. Success toward ending all HIV transmission is possible if we put recent discoveries to work on a massive scale. Why do we think this is possible? In a new article published in the Journal of the Association of Nurses in AIDS Care, we suggest how lessons learn...
This Issue at a Glance
What impact has the current era of combination and retroviral therapy had on long-term outcomes of patients with cytomegalovirus (CMV) and acquired immune deficiency syndrome (AIDS)? Jabs et al (p. 1452) set out to investigate this question and found that the modern era of treatment has had a substantial impact on survival: Affected patients who had immune recovery from antiretroviral therapy had an estimated median survival of 27.0 years, versus 13.5 months for those with no immune recovery. In addition, the rates of ocular complications and vision loss did not differ by immune recovery status and were substantially lower than those observed prior to the advent of current treatments. (Source: Ophthalmology)
????
???????????(AIDS)??????(CMV)?????????????????????????Jabs (p. 1452) ???????????????????????????????????????????????????????????27????????????????13.5????????????????????????????????????????????????????????????????????????????????????1996??????CMV?479????????????(98.1%)???????????????????????? (Source: Ophthalm...
Gambia: Regional Aids Coordinator On HIV/Aids Responses in Crr
[Daily Observer] The Aids coordinator of the Central River Region has informed that the committee has implemented series of activities which include community sensitisation on HIV/AIDS at targeted villages as well as conducted schools sensitisation. (Source: AllAfrica News: Health and Medicine)
Benefits of Early Antiretroviral Therapy With RaltegravirBenefits of Early Antiretroviral Therapy With Raltegravir
When it comes to lowering T-cell activation levels, early vs. late ART initiation doesn't seem to make a difference. AIDS (Source: Medscape Today Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
South Africa: US PEPFAR Program Provides Key for an AIDS-Free Generation
[U.S. Embassy Pretoria] From emergency assistance to sustainability at Nazareth House Johannesburg (Source: AllAfrica News: HIV-Aids and STDs)
[Editorial] Crossing the minefield of disease names
Communities, nations, and economic sectors sometimes experience the negative consequences of being associated with the name of a disease. For example, the original naming of AIDS as ?gay-related immune deficiency? contributed to a strong and enduring stigmatisation of the gay community. A more recent example is the 2009 pandemic of so-called swine flu: despite the fact that disease transmission was human-to-human and pigs were only associated with the origin of the outbreak, the name created widespread fear of possible infection by contact with pigs. (Source: The Lancet Infectious Diseases)
Zambia: Sodomy Spreads HIV/Aids in Prisons - Chato
[Times of Zambia] ZAMBIA Prisons Service commissioner Percy Chato has said sodomy is the biggest contributor of HIV/AIDS in Zambian prisons. (Source: AllAfrica News: HIV-Aids and STDs)
Zambia: HIV/Aids Vaccine a Must
[Times of Zambia] RESEARCHERS, Scientists and Journalists are all agreed that there is need for an HIV vaccine that will stop the further spread of the pandemic. This came to the fore when journalists from Zimbabwe, Malawi and Zambia met during an HIV Vaccines Regional Symposium at Lusaka's ZAMCOM Lodge from June 17, 2015 to June 18, 2015. (Source: AllAfrica News: HIV-Aids and STDs)
Zimbabwe: Man Chases Away HIV Positive Children
[The Herald] A woman last Thursday approached the Harare Civil Court seeking a protection order against her husband whom she accused of chasing away their two children from home because they are HIV-positive. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
General practice web-based decision aid improves MMR vaccination uptake
Commentary on: Tubeuf S, Edlin R, Shourie S, et al. Cost effectiveness of a web-based decision aid for parents deciding about MMR vaccination: a three-arm cluster randomized controlled trial in primary care. Br J Gen Pract 2014;64:e493&ndash;9. Implications for practice and research Decision aids can help inform parents about vaccine decisions for their children, which is critical in an age of vaccine hesitancy and refusal. Web-based decision aids may be a low-cost or free means of helping parents to understand the measles, mumps, and rubella (MMR) vaccination, supplementing information they receive from healthcare providers. Context It is not uncommon for parents to express vaccine hesitancy, request modified childhood vaccination schedules, refuse vaccines for their children or file for ...
Factors Associated with Low Levels of HIV Testing among Men Who Have Sex with Men (MSM) in Brazil
by Ana Maria Brito, Carl Kendall, Ligia Kerr, Rosa Maria Salani Mota, Mark Drew Crosland Guimarães, Inês Dourado, Adriana A. Pinho, Adele Schwartz Benzaken, Sandra Brignol, Arthur L. Reingold The aim of this study was to assess risk factors associated with low levels of HIV testing among MSM recruited through respondent driven sampling (RDS) in Brazil. Of 3,617 participants, 48.4% had never tested previously for HIV. A logistic model indicated that younger age, lower socioeconomic class, education, poor HIV/AIDS knowledge, no history of cruising, and having been tested during the study were characteristics independently associated with low levels of previous HIV testing. The HIV testing rate among MSM in Brazil is still low in spite of the availability of a large number services providi...
Effect of highly active antiretroviral therapy use on oral manifestations in pediatric patients infected with HIV
Conclusions: Although the prevalence of oral lesions was similar between the groups, it was less in patients without AIDS and those under HAART. The duration of HAART usage had a significant influence on the prevalence of these lesions. (Source: Table of Contents : Indian Journal of Dental Research : 2006 - 17(3))
Prevalence and Severity of Oral Diseases in the Africa and Middle East Region
This review aims to determine the prevalence and severity of oral health diseases in the Africa and Middle East region (AMER). The profile of oral diseases is not homogeneous across the AMER. There are large disparities between groups. Reliable data are scarce. The prevalence and severity of oral diseases appear to be increasing in the African region, as does associated morbidity. There are substantial differences in inequalities in oral health. Dental caries prevalence is less severe in most African countries than in developed countries, but the high rate of untreated caries reflects the limited resources available and difficulties of access and affordability to essential oral health care services. The prevalence of gingival inflammation is very high in all age groups in several African c...
How later adolescents with adult responsibilities experience HIV bereavement in Nigeria: Application of a bereavement model
Conceptual models assist in the better understanding of phenomena and also in the planning of effective responses. We applied the Dual Process Model (DPM) to examine how 6 later adolescents (ages 18-24 years) experienced the multiple stressors of bereavement, maturational task, and caregiving roles. Using a semi-structured interviewing approach, participants who were purposively recruited narrated how parental loss to HIV impacted their lives. In relation to the proposition of the DPM model, the study revealed that participants (a) anticipated grief before the death of their parents, (b) engaged in activities to return to normalcy after parental loss, and (c) neglected grief emotions in order to cope with the demands of caregiving. (Source: Journal of the Association of Nurses in AIDS Care...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Gene therapy: a possible future standard for HIV care.
Authors: Abou-El-Enein M, Bauer G, Reinke P Abstract Despite undeniable accomplishments in developing cell and gene therapeutic strategies to combat HIV infection, key social, economic, and policy-related challenges still need to be overcome for any future commercialization efforts of these novel therapies to be successful. Here, we address these challenges and structure a framework for eradicating HIV/AIDS using gene therapy. PMID: 26088914 [PubMed - in process] (Source: Trends in Biotechnology)
Teachers? Patterns of Implementation of an Evidence-Based Intervention and Their Impact on Student Outcomes: Results from a Nationwide Dissemination over 24-Months Follow-Up
Abstract More information is needed about factors influencing real-life implementation and program impact of interventions effective in controlled study conditions. Ongoing national implementation of an evidence-based HIV prevention program targeting grade 6 students in The Bahamas offers the opportunity to examine patterns of implementation and relate them to student outcomes. Data were collected from 208 grade 6 teachers, 75 grade 7 teachers and 4411 grade 6 students followed over 2 years. Mixed-effects modeling analysis examined the association of teachers? patterns of implementation with student outcomes. High quality program implementation in grade 6 (high implementation dosage and fidelity) was significantly related to student outcomes six and 18 months post-intervent...
Trends and Predictors of Cigarette Smoking Among HIV Seropositive and Seronegative Men: The Multicenter Aids Cohort Study
Abstract We measured the trend of cigarette smoking among HIV-seropositive and seronegative men over time from 1984 to 2012. Additionally, we examined the demographic correlates of smoking and smoking consumption. Six thousand and five hundred and seventy seven men who have sex with men (MSM) from the Multicenter AIDS Cohort Study (MACS) were asked detailed information about their smoking history since their visit. Prevalence of smoking and quantity smoked was calculated yearly from 1984 to 2012. Poisson regression with robust error variance was used to estimate prevalence ratios of smoking in univariate and multivariate models. In 2012, 11.8 and 36.9 % of men who were enrolled in the MACS before 2001 or during or after 2001 smoked cigarettes, respectively. In the multivariate an...
HIV Testing Characteristics Among Hispanic Adolescents
Abstract Hispanic adolescents are disproportionally impacted by HIV/AIDS. Among Hispanic people living with HIV, delayed testing and late entry into HIV care have been documented. The current study examined Hispanic adolescents? HIV testing characteristics and factors related to testing. Adolescents aged 13?16 (N = 223) completed a survey on HIV testing motivation, perceptions, and experience, sexual behavior, and substance use. Results indicate few adolescents (9 %) had taken an HIV test. Among those who have not been tested, 32.5 % expressed interest in testing. HIV testing was favorably perceived with 82.4 % reported testing should be done with all youth or those are sexually active. Adolescents who had engaged in high risk behaviors (history of sexual intercourse,...
Aichi Virus Positivity in HIV-1 Seropositive Children Hospitalized with Diarrheal Disease.
Authors: Rodrigues Portes SA, Mello Volotao Ed, Rose TL, Rocha MS, Trindade Pinheiro Xavier Mda P, de Assis RM, Fialho AM, Rocha MS, Miagostovich MP, Gagliardi Leite JP, Carvalho-Costa FA Abstract Aichi viruses (AiV) have been detected in patients with diarrheal diseases (DD). The aim of this study was to assess AiV infection rates in hospitalized children with DD, including 123 HIV-1 seropositive and 125 HIV-1 seronegative patients, in two public pediatric hospitals in Rio de Janeiro, Brazil. AiV was investigated by nested RT-PCR. The AiV-positive samples were also tested for specie A rotavirus, norovirus, astrovirus, enteric adenovirus and bocavirus in order to assess co-infections. AiV parcial genome sequencing and phylogenetic analyses were performed. AiV were detected in 9/123...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Exploring the Routine Administration of Decision Aids for Palliative Chemotherapy to Patients by Nurses: A Qualitative Study Among Nurses and Oncologists
Conclusions: Most nurses and oncologists were open to the future use of the DAs by nurses, provided that certain barriers, particularly related to professionals? opinions and attitudes and logistical procedures in the organization, could be overcome. Implications for Practice: These findings can inform a tailored strategy to implement DAs on palliative chemotherapy. Implementation should start with interventions to motivate professionals, for example, educational meetings. (Source: Cancer Nursing)
How Dads In Malawi Are Reducing HIV Rates Among Babies
This Father?s Day, dads in Malawi can celebrate stepping up to ensure their babies get the best chance at survival. Just five years ago, males in Malawi simply did not participate is women?s antenatal care services, which had a grievous effect on the way pregnant women with HIV addressed their health needs, according to UNICEF. But that figure has improved dramatically recently thanks to a government program that?s working to break the stigma around the issue and encourage men to be more involved in their wives? well-being. Every year, 40,000 babies in Malawi are born with HIV, a statistic that could be significantly reduced if women got tested and the appropriate treatment, according to UNICEF. So, in 2012, with support from UNICEF and other agencies, the Ministry of Health in...
Long-Term Results of TORP-Vibroplasty
Conclusion: The good outcomes of TORP-vibroplasty in chronic disabled ears are stable. They provide long-term and long-lasting satisfying audiologic results combined with a high satisfaction of the patient. Prerequisite is the stable attachment to the cochlear windows. (Source: Otology and Neurotology)
Real-World Verbal Communication Performance of Children Provided With Cochlear Implants or Hearing Aids
Conclusion: Real-world verbal communication abilities of children with CIs are similar to those of children with moderate-to-severe hearing loss using amplification. Because hearing age significantly influences performance, children with moderate-to-severe hearing loss using HAs and implanted children catch up with children with mild hearing loss at a hearing age of approximately 3 years. (Source: Otology and Neurotology)
Audiometry-Based Screening Procedure for Cochlear Implant Candidacy
Conclusion: CI candidacy can be predicted based on commonly used audiometric measures. Cochlear implant candidacy may be considered if the difference between the average pure-tone threshold (in decibels) and PBmax (in percent) exceeds 8. (Source: Otology and Neurotology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Monitoring the Impacts of Wildfires on Forest Ecosystems and Public Health in the Exo-Urban Environment Using High-Resolution Satellite Aerosol Products from the Visible Infrared Imaging Radiometer Suite (VIIRS).
Authors: Huff AK, Kondragunta S, Zhang H, Hoff RM Abstract Increasing development of exo-urban environments and the spread of urbanization into forested areas is making humans and forest ecosystems more susceptible to the risks associated with wildfires. Larger and more damaging wildfires are having a negative impact on forest ecosystem services, and smoke from wildfires adversely affects the public health of people living in exo-urban environments. Satellite aerosol measurements are valuable tools that can track the evolution of wildfires and monitor the transport of smoke plumes. Operational users, such as air quality forecasters and fire management officials, can use satellite observations to complement ground-based and aircraft measurements of wildfire activity. To date, wildfi...
A Systematic Review of Adjuvant Interventions for Radioiodine in Patients with Thyroid Cancer
Conclusions: The present systematic review suggests that rhTSH, lithium, and computerized decision aids maybe act as beneficial adjuvant interventions for radioiodine in patients with thyroid cancer; however, amifostine does not exhibit helpful effects in thyroid cancer patients treated with radioiodine.Oncol Res Treat (Source: Oncology Research and Treatment)
Adverse events and adherence to HIV post-exposure prophylaxis: a cohort study at the Korle-Bu Teaching Hospital in Accra, Ghana
Background: There is strong evidence that post-exposure prophylaxis (PEP) with antiretroviral drugs in the timely management of occupational exposures sustained by healthcare workers decreases the risk of HIV infection and PEP is now widely used. Antiretroviral drugs have well documented toxicities and produce adverse events in patients living with HIV/AIDS. In the era of ?highly active antiretroviral therapy?, non-adherence to treatment has been closely linked to the occurrence of adverse events in HIV patients and this ultimately influences treatment success but the influence of adverse events on adherence during PEP is less well studied. Methods: Following the introduction of a HIV post-exposure prophylaxis program in the Korle-Bu Teaching Hospital in January 2005, the incidence of ...
The initial steps of operating room emergency checklist
One hundred years ago, the surgeon W Wayne Babcock called for emergency protocols to be rehearsed and ?posted on the walls of every operating room? after observing that readily accessible cognitive aids would have improved the treatment of his own patients [1]. The purpose of checklists in the operating room is to ensure that critical steps in preparing for and performing operations are taken and not left to memory [2]. (Source: Journal of Clinical Anesthesia)
Lipodystrophy among HIV-infected patients: a cross-sectional study on impact on quality of life and mental health disorders
Conclusions: LD, depression and anxiety were frequent features among HIV-infected individuals seen in the metabolic clinic and significantly impacted on their quality of life. (Source: AIDS Research and Therapy)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Risk Factors for HIV Acquisition in a Prospective Nairobi-Based Female Sex Worker Cohort
Abstract With two million new HIV infections annually, ongoing investigations of risk factors for HIV acquisition is critical to guide ongoing HIV prevention efforts. We conducted a prospective cohort analysis of HIV uninfected female sex workers enrolled at an HIV prevention clinic in Nairobi (n = 1640). In the initially HIV uninfected cohort (70 %), we observed 34 HIV infections during 1514 person-years of follow-up, i.e. an annual incidence of 2.2 % (95 % CI 1.6?3.1 %). In multivariable Cox Proportional Hazard analysis, HIV acquisition was associated with a shorter baseline duration of sex work (aHR 0.76, 95 % CI 0.63?0.91), minimum charge/sex act (aHR 2.74, 0.82?9.15, for low vs. intermediate; aHR 5.70, 1.96?16.59, for high vs. intermediate), N. gonorrhoeae inf...
Utility of absolute lymphocyte count for the monitoring of AIDS patients
Conclusions This study showed an optimum cut-off value for ALC correlated with CD4 count ?200/?l to be 1646/?l and with CD4 count ?350 was 2009/?l. This is quite high compared to the WHO guideline of ALC of 1200/?l. A higher cut-off of ALC may help to reduce failure rate by identifying patients who might benefit from ART prophylaxis. The sensitivity of ALC of 2009/?l correlating CD4 count ?350/?l was higher than ALC of 1646/?l correlating with CD4 count ?200/?l. Therefore ALC can be used as a surrogate for CD4 counts as a screening test to initiate and monitor ART for HIV patients in resource poor setting. (Source: Current Medicine Research and Practice)
Understanding the Relationship Between Walking Aids and Falls in Older Adults: A Prospective Cohort Study
Conclusions: Using walking aids is a risk factor for future falls among the older population living in residential settings. A substantial proportion of the relationship between walking aids and future falls could be explained by an altered spatiotemporal gait pattern, increased age, and psychotropic drug intake. This finding supports the aim of extensive training periods and appropriate instructions on the proper use of walking aids in terms of adequate and safe gait patterns. (Source: Journal of Geriatric Physical Therapy)
Community perceptions of childbearing and use of safer conception strategies among HIV-discordant couples in Kisumu, Kenya.
CONCLUSIONS: Many community members noted a need and desire for safer conception education and services in Kisumu. However, community barriers such as fear, stigma and lack of information should be addressed before safer conception interventions can be successfully implemented and delivered. Further research focused on community education, male engagement and healthcare provider training is a crucial next step in delivering safer conception in this region. PMID: 26077644 [PubMed - in process] (Source: Journal of the International AIDS Society)
The availability of essential medicines for mental healthcare in Sofala, Mozambique.
CONCLUSIONS: Essential psychotropic medicines are routinely unavailable at public health facilities. Current essential drug lists include six typical but no atypical antipsychotics, which is concerning given the side-effect profiles of typical antipsychotics. Ensuring consistent availability of at least one selective serotonin reuptake inhibitor should also be a priority, as they are essential for the treatment of individuals with underlying cardiovascular disease and/or suicidal ideation. Similar to successful task-sharing approaches used for HIV/AIDS, mid-level providers could be retrained and certified to prescribe and monitor first-line psychotropic regimens. PMID: 26081970 [PubMed - in process] (Source: Global Health Action)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
CDC-funded HIV Testing, United States, Puerto Rico, and U.S. Virgin Islands, 2013
This report includes HIV testing data from 61 CDC-funded health department jurisdictions and 151 directly funded community-based organizations (CBOs). NHM&E HIV testing data are used in conjunction with other information (e.g., progress reports, surveillance data, and census data) by HIV program managers and policy makers, HIV testing service providers, CDC project officers, evaluators, researchers, and others interested in the public health implications of HIV prevention program activities (Source: CDC HIV/AIDS Prevention)
Medical News Today: Scripps team lays 'spectacular' foundations for HIV vaccine
Researchers at The Scripps Institute report preliminary success in designing a component for a potential HIV vaccine based on immunogens, rather than a deactivated virus. (Source: Health News from Medical News Today)
Rwanda: Rose Uwabasinga, A Woman At the Forefront in the Fight Against HIV
[Focus] Rose Uwabasinga, the president of the International Community of Women Living with HIV in Rwanda, has urged the general public, including leaders, to boost the HIV/AIDS fight by declaring their status. Born in Huye District Southern Province in 1963, the former teacher at Lycee Notre Dame de Citeaux (Kigali) realized that she had HIV in 1994 and dedicated her life to advocating for women living with the virus. The Rwanda Focus held an exclusive interview with her and brings you the (Source: AllAfrica News: Health and Medicine)
North Korea Claims It Has Found Cure For MERS, Ebola, SARS And AIDS
SEOUL, South Korea (AP) ? North Korea says it has succeeded where the greatest minds in science have failed. The authoritarian, impoverished nation better known for pursuing a nuclear program despite global criticism announced Friday it has a drug can prevent and cure MERS, Ebola, SARS and AIDS. The secretive state did not provide proof, and the claim is likely to provoke widespread skepticism. The official Korean Central News Agency said scientists developed Kumdang-2 from ginseng grown from fertilizer mixed with rare-earth elements. According to the pro-North Korea website Minjok Tongshin, the drug was originally produced in 1996. "Malicious virus infections like SARS, Ebola and MERS are diseases that are related to immune systems, so they can be easily treated by Kumdang-2 injecti...
South Africa: Seventh Country AIDS 2015 Conference Opening Plenary
[U.S. Embassy Pretoria] Remarks by Ambassador Patrick H. Gaspard (As prepared) (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
North Korea claims 'cure' for Mers, Aids and Ebola
State media say scientists have developed a vaccine for ?malicious infections?, including the respiratory disease currently sweeping through Asia North Korea says it has succeeded where the greatest minds in science have failed.The authoritarian, impoverished nation announced it has a drug that can prevent and cure Mers, Ebola, Sars and Aids. Continue reading... (Source: Guardian Unlimited Science)
Africa: Global Fund Announces Plans to Make Some Concept Note Attachments Public
[GFO] Decision follows request from Aidspan to increase access to documents related to concept notes and the ensuing grants (Source: AllAfrica News: HIV-Aids and STDs)
Effects of Mobility Grade, Age, and Etiology on Functional Benefit and Safety of Subjects Evaluated in More Than 1200 C-Leg Trial Fittings in Germany
Conclusions: Responders are not limited to specific age groups, MGs, or amputation etiologies. The utilization of functional benefits is not correlated with age, MG, or etiology of the amputation nor do any of these factors possess any relevant predictive power. Rather, the responsiveness is highly independent of age, MG, and amputation etiology. Furthermore, it seems that technology itself substantially influences MG rating. Therefore, we find it important that the potential benefits of an microprocessor-controlled knee (MPK) are assessed on an individual basis. The present study suggests that a prediction of an individual?s capability to utilize the functional benefits of C-Leg solely on grounds of the aforementioned factors or their interdependencies is hard to argue. (Source: JPO Jou...
Malawi: Concerns About Malawi Financial Management Outweighed By Burden of Need
[GFO] Despite scandal involving parastatal principal recipient, Malawi receiving additional resources from Global Fund (Source: AllAfrica News: HIV-Aids and STDs)
Africa: Global Input Sought in Development of Strategic Plan to Stop TB
[GFO] The online consultation follows a similar effort launched to solicit greater input into the global HIV strategy (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Namibia: Local Pharmaceutical Manufacturer Ventures Into Anti-Retrovirals
[Namibia Economist] Local pharmaceutical manufacturer, Fabupharm earlier this week announced the signing of an agreement of collaboration with the Northwest University in South Africa (NWU) which will enable the two to share product development and patent information, and collaborate on product research. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: Aidspan Launches Its Open Data Platform
[GFO] The Aidspan Portal Workbench is web tool that will be useful to all persons interested in Global Fund grant data (Source: AllAfrica News: HIV-Aids and STDs)
Africa: Sub-Recipient Selection in Russia Underway for HIV Grant
[GFO] The Open Health Institute (OHI) is close to choosing the 26 sub-recipients to implement activities under the $11-million HIV grant awarded to Russia under the new funding model. Implementation of activities specifically targeting key populations should begin in July following their selection. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: Drought Increases the Spread of HIV in Africa
[IFPRI] Washington, D.c. -Bad weather in Africa south of the Sahara increases the spread of HIV, according to a study published in the June 2015 issue of the Economic Journal. When the rains fail, farmers in rural areas often see their incomes fall dramatically and will try to make up for it however they can, including through sex work. Analyzing data on more than 200,000 individuals across 19 African countries, the research team finds that by changing sexual behavior, a year of very low rainfall can increase local infection rates (Source: AllAfrica News: HIV-Aids and STDs)
Mozambique: 374 Million Dollars Against Aids, TB and Malaria
[AIM] Maputo -The Global Fund to Fight AIDS, Tuberculosis and Malaria on Wednesday announced that 374 million US dollars will be disbursed to fight these diseases in Mozambique, according to a report on the independent television channel, STV. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Implementation and Operational Research: High Loss to Follow-up Among Children on Pre-ART Care Under National AIDS Program in Madurai, South India
Background: Information on the follow-up of HIV-infected children enrolled into preantiretroviral therapy (Pre-ART) care under routine program settings is limited in India. Knowledge on the magnitude of loss to follow-up (LFU) and its reasons will help programs to retain children in HIV care. We aimed to assess the proportion of LFU among children in Pre-ART care and its associated factors. Methods: In this retrospective cohort study, we reviewed the records of all HIV-infected children (aged (Source: JAIDS Journal of Acquired Immune Deficiency Syndromes)
Implementation and Operational Research: Effect of Universal Access to Antiretroviral Therapy on HIV/AIDS Mortality in Mexico 1990?2011
Conclusions: Access to universal HAART has had relative success in Mexico. The heterogeneity of HIV/AIDS mortality by employment status, gender, and state of residence highlight urgent needs to improve health equity with pro-poor and gender-responsive programs and a call for country-specific operational research in HIV/AIDS prevention and treatment. Our results may apply to other countries seeking to implement universal access to antiretroviral therapy. (Source: JAIDS Journal of Acquired Immune Deficiency Syndromes)
Injection Drug Use and Hepatitis C as Risk Factors for Mortality in HIV-Infected Individuals: The Antiretroviral Therapy Cohort Collaboration
Conclusions: A substantial proportion of the excess mortality in HIV-infected IDU is explained by HCV coinfection. These findings underscore the potential impact on mortality of new treatments for HCV in HIV-infected people. (Source: JAIDS Journal of Acquired Immune Deficiency Syndromes)
An Algorithm Approach to Determining Smoking Cessation Treatment for Persons Living With HIV/AIDS: Results of a Pilot Trial
Conclusions: This algorithm-derived treatment produced positive changes across a number of important clinical markers associated with smoking cessation. Given these promising findings coupled with the brief nature of this treatment, the overall pattern of results suggests strong potential for dissemination into clinical settings and significant promise for further advancing clinical health outcomes in this population. (Source: JAIDS Journal of Acquired Immune Deficiency Syndromes)
HIV Cascade Monitoring and Simple Modeling Reveal Potential for Reductions in HIV Incidence
Abstract: To estimate the potential reduction in HIV incidence, we constructed a risk equation based on a flow diagram of the HIV cascade, linking HIV diagnosis and treatment coverage with estimates of annual incidence and prevalence. This was applied to numerous settings. Some countries have already achieved high diagnosis and treatment levels, and if the Joint United Nations Programme on HIV/AIDS (UNAIDS) targets of 90% diagnosis and 90% antiretroviral therapy (ART) coverage were achieved, then population incidence could not reduce very substantially. Other countries have a high HIV diagnosis level but low treatment coverage; the United States, for example, could expect to achieve up to a 50% reduction in incidence by prioritizing treatment scale-up to achieve a 48% increase among those ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Update to Guidelines on HIV Post-exposure ProphylaxisUpdate to Guidelines on HIV Post-exposure Prophylaxis
Dr Samuel Merrick discusses important aspects of guideline-recommended care for prophylaxis following exposure to HIV. Medscape HIV/AIDS (Source: Medscape Hiv-Aids Headlines)
UCLA research offers more evidence for possible link between cocaine use and HIV infection
This study shows that under the same transmission conditions, drug exposure enhances infection through a collective of biological changes.? This study builds on previous research by Vatakis and others on his team showing that a three-day exposure to cocaine appears to make a unique population of immune cells called quiescent CD4 T cells, which are resistant to HIV, more susceptible to infection by stimulating two receptors in the cells, called ?1 and D4. Those findings suggested that cocaine use increases the pool of CD4 T cells in the human body that can become infected by the virus. As a result, the odds for productive infection and a larger viral reservoir increase. That study, however, was based on in-vitro research ? that is, research done in a petri dish ? which could have s...
Re-shaping HIV Interventions with Technology
(Source: AIDS and Behavior)
A systematic review of post-migration acquisition of HIV among migrants from countries with generalised HIV epidemics living in Europe: mplications for effectively managing HIV prevention programmes and policy
Conclusions: There is post-migration HIV acquisition among migrants in European countries but this is difficult to quantify accurately with current data. Migrant MSM appear at particular risk of HIV acquisition post-migration. Countries that identify migrants as an important part of their HIV epidemic should focus on using an objective method for assigning probable country of HIV acquisition. Robust methods to measure HIV incidence should be considered in order to inform national prevention programming and resource allocation. (Source: BMC Public Health)
Correction
Quesada AE, Tholpady A, Wanger A, et al. Utility of bone marrow examination for workup of fever of unknown origin in patients with HIV/AIDS.&nbsp;J Clin Pathol 2015;68:241&ndash;5. doi:10.1136/jclinpath-2014-202715 The following sentence has been amended to read: The average white blood cell count for all patients was 3.8 x109/L (range 0.1&ndash;23.7 x109/L). The average haemoglobin was 91&nbsp;g/L (range 54&ndash;135&nbsp;g/L). The average platelet count was 146 x109/L (range 4&ndash;642 x109/L). (Source: Journal of Clinical Pathology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
[In Depth] Designer proteins produce potent HIV defense
Three new studies report progress in the drive to rationally design AIDS vaccines that can teach the immune system how to mount an effective antibody response against the virus. Some HIV-infected people make "broadly neutralizing" antibodies (bNAbs) that work against a wide array of viral variants, but researchers have struggled to figure out how to reverse engineer them. Two reports online this week in Science and one in Cell show in animal experiments that two different approaches can help steer antibody-producing B cells onto pathways that ultimately will produce bNAbs. One strategy uses a nanoparticle based on a small part of HIV's surface protein, gp120, as an "immunogen" to kick-start the bNAb process. A second effort uses a natural mimic of the entire gp120 as it appears on viral su...
Effects of an environmental tax on meat and dairy consumption in Sweden
This study evaluated the environmental impacts of introducing an environmental tax on meat and dairy consumption in Sweden. Three meat products (beef, pork and chicken), four dairy products (milk, fermented products, cream and cheese) and four pollutants generating environmental damage (greenhouse gases (GHG), nitrogen, ammonia and phosphorus) were included in the analysis. The unit tax applied corresponded to between 8.9% and 33.3% of the respective price per kg product in 2009. Consumer response to the tax was calculated by econometric estimates of the almost ideal demand system (AIDS) for meat and dairy products, using per capita consumption data and prices. The results indicated relatively inelastic own price elasticities and high income elasticities for all meat products and slightly ...
Professional's Attitudes Do Not Influence Screening and Brief Interventions Rates for Hazardous and Harmful Drinkers: Results from ODHIN Study
Conclusion The findings show that the studied factors (role security and therapeutic commitment) are not of great importance for alcohol screening and BI rates. Given the fact that screening and brief intervention implementation rate has not changed much in the last decade in spite of increased policy emphasis, training initiatives and more research being published, this raises a question about what else is needed to enhance implementation. (Source: Alcohol and Alcoholism)
Clinical handovers between prehospital and hospital staff: literature review
Conclusions This review raises concerns about handovers at the interface between prehospital and hospital settings. The quality of existing research in this area is relatively poor and further high-quality research is required to understand this important part of emergency care. We need to understand the complexity of handover better to grasp the challenges of context and interprofessional relationships before we reach for tools and techniques to standardise part of the handover process. (Source: Emergency Medicine Journal)
June 27 is National HIV Testing Day
Plan to participate in National HIV Testing Day on June 27! The annual observance is a time to promote HIV testing&mdash;one of the best tools for HIV prevention. The Centers for Disease Control and Prevention (CDC) recommends that everyone between the ages of 13 and 64 get tested for HIV at least once as part of routine health care. Some people with risk factors for HIV should get tested more often.&nbsp; Visit our National HIV Testing Day webpage [en espa&ntilde;ol] to learn more about the observance and to find information and resources about HIV testing. (Source: AIDSinfo At-a-Glance: Offering Information on HIV/AIDS Treatment, Prevention, and Research, A Service of the U.S. Department of Health and Human Services (DHHS))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
National Library of Medicine Announces Solicitation of Quotations for the 2015 HIV/AIDS Community Information Outreach Projects
The National Library of Medicine (NLM) is pleased to announce the solicitation of quotations from organizations and libraries to design and conduct projects for improving HIV/AIDS information access for patients and the affected community as well as their caregivers and the general public. Patients and the affected community need access to the most up-to-date and accurate health information to effectively manage and make informed decisions about their health. Health care providers and health educators also need access to the most current information to provide the highest quality of care. NLM is committed to assisting organizations in accessing the spectrum of information resources and services that are currently available. The NLM is particularly interested in proposals with creative and ...
Effects of adherence to antiretroviral therapy on body mass index, immunological and virological status of Nigerians living with HIV/AIDS
Conclusion Adherence to HAART reduced viral load to an undetectable level and increased CD4 count among adherent PLWHA on HAART. (Source: Alexandria Journal of Medicine)
Africa: UNAIDS Leads the Way
[Global Fund] People who work in public health have become wary of dramatic headlines about medical breakthroughs. It's not that we don't welcome scientific advances. It's that we know that without political will and financial commitment, the most promising new medicine will barely get anywhere against an epidemic. (Source: AllAfrica News: HIV-Aids and STDs)
Mozambique: Fight Against HIV Costs U.S $350 Million a Year
[AIM] The fight against the HIV/ADS epidemic in Mozambique has in recent years cost an average of US$350 million a year. (Source: AllAfrica News: HIV-Aids and STDs)
Zimbabwe: When Beliefs Go Wrong
[The Herald] Six-month-old Baby Tadiwa was always sick. Prophets did all they could, but still the diarrhoea and cough did not go. Eventually Tadiwa died in January this year and was buried a few metres from her sister, who also died two years ago. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Bodybuilders 'could get HIV from drinking human breast milk'
Human breast milk sold online is not screened, buyers could be exposed to infectious diseases including hepatitis, HIV and syphilis (Source: Telegraph Health)
HIV and Coronary Arterial Remodeling from the Multicenter AIDS Cohort Study (MACS) Miller, HIV and coronary artery remodeling
Positive remodeling (PR), a coronary artery characteristic associated with risk for myocardial infarction (MI), may be more prevalent in HIV-infected (HIV+) people. We evaluated the prevalence of PR using coronary CT angiography (CCTA) in HIV+ and HIV-uninfected (HIV-) men. (Source: Atherosclerosis)
Ending Sexual HIV Transmission: Lessons Learned from Perinatal HIV
Data presented at the 2015 Conference on Retroviruses and Opportunistic Infections (February, Seattle, WA) confirmed that oral emtricitabine/tenofovir used as preexposure prophylaxis (PrEP) for HIV infection was highly effective. The Ipergay and PROUD studies both demonstrated an 86% reduction in HIV incidence in men who have sex with men randomized to receive active drug (McCormack & Dunn, 2015; Molina et al., 2015). The HPTN 067 ADAPT trial showed that high levels of PrEP adherence occurred in a sample of young women (Bekker et al., 2015). (Source: Journal of the Association of Nurses in AIDS Care)
Clinical versus laboratory screening for sexually transmitted infections prior to insertion of intrauterine contraception among women living with HIV/AIDS: a randomized controlled trial
STUDY QUESTION Does laboratory testing after syndromic screening for sexually transmitted infections (STIs) reduce the rate of intrauterine contraception (IUC) removal among women living with HIV/AIDS (WLHA)? SUMMARY ANSWER Additional laboratory testing after syndromic screening for STIs did not affect the likelihood that a woman would remove an IUC immediately or within 1 year of IUC use or the frequency of post-insertion unscheduled clinic visits. In low-risk WLHA, the incidence rate of IUC removal is low with or without laboratory testing. WHAT IS KNOWN ALREADY Fear of infectious morbidity remains an obstacle to uptake of IUC by WLHA. The value of laboratory testing after syndromic screening for STI before the insertion of IUC remains uncertain. STUDY DESIGN, SIZE, DURATION We enroll...
Chloroquine and beyond: exploring anti-rheumatic drugs to reduce immune hyperactivation in HIV/AIDS
The restoration of the immune system prompted by antiretroviral therapy (ART) has allowed drastically reducing the mortality and morbidity of HIV infection. However, one main source of clinical concern is the persistence of immune hyperactivation in individuals under ART. Chronically enhanced levels of T-cell activation are associated with several deleterious effects which lead to faster disease progression and slower CD4 + T-cell recovery during ART. In this article, we discuss the rationale, and review the results, of the use of antimalarial quinolines, such as chloroquine and its derivative hydroxychloroquine, to counteract immune activation in HIV infection. Despite the promising results of several pilot trials, the most recent clinical data indicate that antimalaria...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Global Public Awareness of Venous Thromboembolism.
CONCLUSIONS: On a global level, public awareness about thrombosis overall, and of VTE in particular, is low. Campaigns to increase public awareness about VTE are needed to reduce the burden from this largely preventable thrombotic disorder. This article is protected by copyright. All rights reserved. PMID: 26084415 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Assistive technology for children and young people with low vision.
CONCLUSIONS: High-quality evidence about the usefulness of electronic AT for children and young people with visual impairment is needed to inform the choice healthcare and education providers and family have to make when selecting a technology. Randomised controlled trials are needed to assess the impact of AT. Research protocols should carefully select outcomes relevant not only to the scientific community, but more importantly to families and teachers. Functional outcomes such as reading accuracy, comprehension and speed should be recorded, as well as the impact of AT on independent learning and quality of life. PMID: 26086876 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Acoustical and perceptual comparison of noise reduction and compression in hearing aids.
Conclusions: Differences in processing between hearing aids are perceptually salient. The effect of compression should be taken into account during the development and evaluation of hearing-aid noise reduction. PMID: 26090648 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)
HIV and coronary arterial remodeling from the Multicenter AIDS Cohort Study (MACS)
Positive remodeling (PR), a coronary artery characteristic associated with risk for myocardial infarction (MI), may be more prevalent in HIV-infected (HIV+) people. We evaluated the prevalence of PR using coronary CT angiography (CCTA) in HIV+ and HIV-uninfected (HIV?) men. (Source: Atherosclerosis)
Disseminated Infections with Talaromyces marneffei in Non-AIDS Patients Given Monoclonal Antibodies against CD20 and Kinase Inhibitors.
We report disseminated T. marneffei infection in 4 hematology patients without AIDS who received targeted therapy with monoclonal antibodies against CD20 or kinase inhibitors during the past 2 years. Clinicians should be aware of this emerging complication, especially in patients from disease-endemic regions. PMID: 26079984 [PubMed - as supplied by publisher] (Source: Emerging Infectious Diseases)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Trends in prevalence of diarrhoea, Kaposi's sarcoma, bacterial pneumonia, malaria and geohelminths among HIV positive individuals in Uganda.
CONCLUSIONS AND RECOMMENDATIONS: Overall, decreasing trends were observed in the above OIs. However the trends differed significantly by OI, geographical location and demographic characteristics. There is urgent need to integrate interventions targeting malaria and geohelminths in HIV programmes. PMID: 26075005 [PubMed] (Source: AIDS Research and Therapy)
Smartphone Self-Monitoring Among People Living With HIVSmartphone Self-Monitoring Among People Living With HIV
How can smart phones be used to engage HIV patients in active self-management? JAIDS: Journal of Acquired Immune Deficiency Syndromes (Source: Medscape Today Headlines)
Miley Cyrus donates Caitlyn Jenner artwork, raises $69,000 for AIDS research
NEW YORK (Reuters) - Pop singer Miley Cyrus daubed glitter and paint over magazine covers showing transgender reality TV star Caitlyn Jenner, then donated them to a gala auction, raising $69,000 for AIDS research. (Source: Reuters: Health)
Rehab-let: touchscreen tablet for self-training impaired dexterity post stroke: study protocol for a pilot randomized controlled trial
DiscussionThe outcomes of this study will inform the design of a fully powered randomized controlled trial to evaluate the effectiveness of Rehab-let. If found to be effective, Rehab-let can be used during subacute rehabilitation to increase treatment intensity and improve dexterity. Potentially, Rehab-let can also be used after discharge and might be ideal for individuals with mild stroke who are often not referred to formal rehabilitation.Trial RegistrationCurrent Controlled Trials NCT02136433 registered on 17 September 2014. (Source: BioMed Central)
Senegal: Senegal and Global Fund Partners Invest in HIV Programs
[Global Fund] Dakar, Senegal -The Government of Senegal and the Global Fund reaffirmed their partnership today by signing two new grant agreements totaling ?19.4 million to support programs against HIV. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Malawi: Malawi Gets Mk 95 Million Boost for HIV Fight
[Malawi24] The United States of America has pumped funds amounting to MK 95 Million to the Malawi government to help in the continued fight against HIV/AIDS, officials at Malawi's Ministry of Health say. (Source: AllAfrica News: HIV-Aids and STDs)
Botswana: Youth Ministry, Vmsac Partner in HIV-Aids Campaign
[Botswana Daily News] Artesia -The Ministry of Youth, Sport and Culture (MYSC) in collaboration with Artesia Village Multisectoral AIDS Committee (VMSAC) organised an HIV/AIDS campaign to create awareness among young people (Source: AllAfrica News: HIV-Aids and STDs)
Malawi: Nsanje Youths Shun HTC Services
[Malawi News Agency] Nsanje -Malawi News Agency has learnt that many youthsin Nsanje are shunning HIV Testing and Counseling-HTC services. (Source: AllAfrica News: HIV-Aids and STDs)
Malawi: Zomba CBOs Receive K6.6 Million From NAC
[Malawi News Agency] Zomba -The National Aids Commission has released K6, 611,428.17to enable 25 Community Based Organizations-CBOs in Zomba carry out HIV and AIDS related activities. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: TB Is Treatable and Curable
[The Conversation Africa] More than 1.5 million people die of tuberculosis across the world every year. Although testing and screening has improved and more drugs are available, it is not enough to conquer the scourge. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Effects of premorbid physical activity on stroke severity and post-stroke functioning.
CONCLUSION: There are significant associations between premorbid walking habits and functional status after first-ever stroke. Weekly light-intensity activity, such as walking for more than 30 min, may have a sustained impact on functioning after stroke. PMID: 26073856 [PubMed - as supplied by publisher] (Source: Journal of Rehabilitation Medicine)
Monitoring and switching of first-line antiretroviral therapy in adult treatment cohorts in sub-Saharan Africa: collaborative analysis
Publication date: Available online 16 June 2015 Source:The Lancet HIV Author(s): Andreas D Haas , Olivia Keiser , Eric Balestre , Steve Brown , Emmanuel Bissagnene , Cleophas Chimbetete , François Dabis , Mary-Ann Davies , Christopher J Hoffmann , Patrick Oyaro , Rosalind Parkes-Ratanshi , Steven J Reynolds , Izukanji Sikazwe , Kara Wools-Kaloustian , D Marcel Zannou , Gilles Wandeler , Matthias Egger Background HIV-1 viral load testing is recommended to monitor antiretroviral therapy (ART) but is not universally available. The aim of our study was to assess monitoring of first-line ART and switching to second-line ART in sub-Saharan Africa. Methods We did a collaborative analysis of cohort studies from 16 countries in east Africa, southern Africa, and west Africa that participate in t...
Preventing mother to child transmission of the human immunodeficiency virus in Southern Africa
This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
A Horse in Zebra Stripes: A Peculiar Case of Undetected End-Stage AIDS
Abstract restructured as requested (Source: General Hospital Psychiatry)
Safety Aid Use in Social Anxiety: The Mediating Role of Perceived Control
The use of safety aids, cognitive or behavioral strategies used to reduce or cope with anxiety, has emerged as a key construct of interest in anxiety disorders due to their role in the development and maintenance of anxiety symptoms. It has been suggested that individuals with anxiety engage in safety aid use to reduce their anxiety and feel more in control of a situation; however, no studies to date have examined the association between perceived control, that is, perceived level of control over internal events in anxiety-provoking situations, and the use of safety aids. (Source: Psychiatry Research)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Using space and time to encode vibrotactile information: toward an estimate of the skin's achievable throughput.
Authors: Novich SD, Eagleman DM Abstract Touch receptors in the skin can relay various forms of abstract information, such as words (Braille), haptic feedback (cell phones, game controllers, feedback for prosthetic control), and basic visual information such as edges and shape (sensory substitution devices). The skin can support such applications with ease: They are all low bandwidth and do not require a fine temporal acuity. But what of high-throughput applications? We use sound-to-touch conversion as a motivating example, though others abound (e.g., vision, stock market data). In the past, vibrotactile hearing aids have demonstrated improvement in speech perceptions in the deaf. However, a sound-to-touch sensory substitution device that works with high efficacy and without the ai...
BUILD Health Challenge Aids Communities in Need
An innovative grants program is attempting to reverse the socioeconomic trends that contribute to poor health by supporting local initiatives that address health issues tied to a specific social need. The BUILD Health Challenge recently awarded grants to 18 initiatives designed to solve an ongoing health problem in a particular community. (Source: AAFP News)
Patients Are My Co-Pilot
No longer just passengers, patients are now co-pilots helping to navigate the future of medical progress. But until recently, the pace of progress has been slow. In some diseases, we still utter the words "we haven't seen a new treatment in decades" with a straight face. Decades. Are we seriously accepting this? I recently heard a TedTalk by Andrew Solomon, "Depression, the secret we share," where he described the current treatment options for depression as being full of side effects, costly, and appalling all at the same time. But he is so grateful he lives now and not 50 years ago when there weren't treatment options. "I hope that 50 years hence people will hear about my treatments and be appalled that anyone endured such primitive science," Solomon said. Depression, cancer, Alzheimer'...
Understanding ACA beyond the Headlines
By Neera Kukreja Director, Academic Center Library John H. stronger Hospital of Cook County Chicago, IL I am thankful to the NNLM GMR for providing me the opportunity to attend the symposium ?Affordable Care Act: Access to Care: Libraries making a difference? hosted by NN/LM Middle Atlantic Region in Philadelphia on Friday, April 24, 2015. I went there to gain a better understanding of the Act and to network and hear of how other libraries were dealing with the complex law. It was geared toward a mix of audience from academic health science centers, hospital libraries, public libraries. The Regional Administrator of the Center for Medicare and Medicaid Services (CMS), Nancy O?Connor, gave a wonderful overview of the ACA and Health Insurance Marketplace. She pointed out the challenges...
Air pollution kills more than Aids and malaria COMBINED each year
Air pollution results in 3.2 million deaths each year, from conditions including heart attack, stroke and lung cancer - more than the combined impact of HIV-Aids and malaria, scientists in Texas say. (Source: the Mail online | Health)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Air pollution kills 3.2 million people across the world every year - that's more than Aids and malaria COMBINED
Air pollution results in 3.2 million deaths each year, from conditions including heart attack, stroke and lung cancer - more than the combined impact of HIV-Aids and malaria, scientists in Texas say. (Source: the Mail online | Health)
Periconception HIV Risk Behavior Among Men and Women Reporting HIV-Serodiscordant Partners in KwaZulu-Natal, South Africa
Abstract HIV-infected men and women who choose to conceive risk infecting their partners. To inform safer conception programs we surveyed HIV risk behavior prior to recent pregnancy amongst South African, HIV-infected women (N = 209) and men (N = 82) recruited from antenatal and antiretroviral clinics, respectively, and reporting an uninfected or unknown-HIV-serostatus pregnancy partner. All participants knew their HIV-positive serostatus prior to the referent pregnancy. Only 11 % of women and 5 % of men had planned the pregnancy; 40 % of women and 27 % of men reported serostatus disclosure to their partner before conception. Knowledge of safer conception strategies was low. Around two-thirds reported consistent condom use, 41 % of women and 88 % of men reported antiretr...
Alcohol Use Predicts Sexual Decision-Making: A Systematic Review and Meta-Analysis of the Experimental Literature
Abstract Alcohol is associated with HIV and other sexually transmitted infections through increased sexual risk-taking behavior. Establishing a causal link between alcohol and sexual behavior has been challenging due to methodological limitations (e.g., reliance on cross-sectional designs). Experimental methods can be used to establish causality. The purpose of this meta-analysis was to evaluate the effects of alcohol consumption on unprotected sex intentions. We searched electronic bibliographic databases for records with relevant keywords; 26 manuscripts (k = 30 studies) met inclusion criteria. Results indicate that alcohol consumption is associated with greater intentions to engage in unprotected sex (d +s = 0.24, 0.35). The effect of alcohol on unprotected sex in...
HIV, Hepatitis C, and Abstinence from Alcohol Among Injection and Non-injection Drug Users
Abstract Individuals using illicit drugs are at risk for heavy drinking and infection with human immunodeficiency virus (HIV) and/or hepatitis C virus (HCV). Despite medical consequences of drinking with HIV and/or HCV, whether drug users with these infections are less likely to drink is unclear. Using samples of drug users in treatment with lifetime injection use (n = 1309) and non-injection use (n = 1996) participating in a large, serial, cross-sectional study, we investigated the associations between HIV and HCV with abstinence from alcohol. About half of injection drug users (52.8 %) and 26.6 % of non-injection drug users abstained from alcohol. Among non-injection drug users, those with HIV were less likely to abstain [odds ratio (OR) 0.55; adjusted odds ratio (AOR) 0.5...
Effect of Age at Antiretroviral Therapy Initiation on Catch-up Growth Within the First 24 Months Among HIV-infected Children in the IeDEA West African Pediatric Cohort
We described malnutrition and the effect of age at antiretroviral therapy (ART) initiation on catch-up growth over 24 months among HIV-infected children enrolled in the International epidemiologic Databases to Evaluate Aids West African paediatric cohort. Methods: Malnutrition was defined at ART initiation (baseline) by a Z score (Source: The Pediatric Infectious Disease Journal)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Nigeria: HIV/Aids - Is Nigeria On Course to Winning the War?
[Daily Trust] HIV/AIDS, the National Agency for the Control of AIDS (NACA) has said, is on the decline in Nigeria, and has been in rapid decline for the past five years due to improved funding by the federal government and the sustained efforts of international partners. (Source: AllAfrica News: HIV-Aids and STDs)
What is the criterion for high-performing colonoscopists? Being meticulous!
The incidence and mortality rates of colorectal cancer (CRC) have been declining in the United States over the past 2 decades.1 These declines have been attributed largely to the increased use of colonoscopy, which aids in the detection and removal of precancerous polyps, also known as adenomas.2 Unfortunately, colonoscopy may fail to detect clinically important lesions. Prior studies have reported rates of postcolonoscopy colon cancer, also referred to as interval cancer, of 2% to 7%,3-5 and miss rates for adenomas by tandem colonoscopy of 2% to 26%. (Source: Gastrointestinal Endoscopy)
Nigeria: UNAIDS, NMA Partner On New HIV Treatment Target
[Independent (Lagos)] Abuja -The new treatment target set by the United Nations Programme on HIV/AIDS (UNAIDS) to drastically reduced HIV/AIDS by year 2020 christened 90-90-90 has received the backing of medical doctors under the auspices of Nigeria Medical Association (NMA) and National Association of Resident Doctors (NARD) in the country. (Source: AllAfrica News: HIV-Aids and STDs)
Inpatient dermatology consultation aids diagnosis of cellulitis among hospitalized patients: A multi-institutional analysis
Given its nonspecific physical examination findings, accurately distinguishing cellulitis from a cellulitis mimicker (pseudocellulitis) is challenging. (Source: Journal of the American Academy of Dermatology)
Malawi: First Lady Voted OAFLA VP
[Malawi News Agency] Malawi First Lady Madamme Gertrude Mutharika was on Sunday voted Vice President for Organization of African First Ladies Against HIV & AIDS (OAFLA at a meeting that took place at Sandton Convention Centre in Johannesburg, South Africa. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Malawi: First Lady Appointed VP for African First Ladies Against HIV and Aids
[Nyasa Times] Johannesburg -Malawi's First Lady, Madam Gertrude Mutharika has been elected Vice President of the Organisation of African First Ladies against HIV and AIDS (OAFLA). (Source: AllAfrica News: HIV-Aids and STDs)
Malawi: U.S Donates K95 Million for HIV Fight
[Malawi News Agency] Johannesburg -The United States of America through U.S. President's Emergency Plan for AIDS Relief (PEPFAR) has donated K95 million to Malawi to assist in the fight against HIV and AIDS. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: New HIV Treatment Target - Nigerian Doctors Align With UNAIDS
[Independent (Lagos)] Abuja -Medical doctors in Nigeria under the aegis of Nigeria Medical Association (NMA) and National Association of Resident Doctors (NARD) have aligned with the United Nations Programme on HIV/AIDS (UNAIDS) towards realising the new treatment target set to drastically reduced the burden of HIV/AIDS by year 2020. (Source: AllAfrica News: HIV-Aids and STDs)
Effect of visual aids and individual differences of cognitive traits in judgments on food safety
In this study, participants (nine hundred Japanese women) were presented with explanations of pesticide residue either in written form only or in written form accompanied by a visual aid (functional graph or illustration), and were asked to make judgments on safety for foods that have pesticide residue. Findings through a web-based survey showed that judgments on food safety were highly difficult for laypeople since they had little knowledge of the technical terms used to describe amounts of pesticide residue. We found that although a visual aid showing their functional relationship did not improve understanding of the technical terms, an illustrated visual aid led to both improved understanding and more accurate judgments on safety. We also found that although cognitive traits measured wi...
Tanzania's Countdown to 2015: an analysis of two decades of progress and gaps for reproductive, maternal, newborn, and child health, to inform priorities for post-2015
Publication date: July 2015 Source:The Lancet Global Health, Volume 3, Issue 7 Author(s): Hoviyeh Afnan-Holmes , Moke Magoma , Theopista John , Francis Levira , Georgina Msemo , Corinne E Armstrong , Melisa Martínez-Álvarez , Kate Kerber , Clement Kihinga , Ahmad Makuwani , Neema Rusibamayila , Asia Hussein , Joy E Lawn Background Tanzania is on track to meet Millennium Development Goal (MDG) 4 for child survival, but is making insufficient progress for newborn survival and maternal health (MDG 5) and family planning. To understand this mixed progress and to identify priorities for the post-2015 era, Tanzania was selected as a Countdown to 2015 case study. Methods We analysed progress made in Tanzania between 1990 and 2014 in maternal, newborn, and child mortality, and unmet need for ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Exploring the Potential Cost-Effectiveness of Patient Decision Aids for Use in Adults with Obstructive Sleep Apnea: A Case Study
Conclusions: The cost-effectiveness of PtDAs will depend on contextual factors, but a framework is described for properly considering their long-term cost-effectiveness. A number of important questions around the appropriateness of benefit measurement for PtDA trials are highlighted. (Source: Medical Decision Making)
Cohort Profile: The Malawi Longitudinal Study of Families and Health (MLSFH)
The Malawi Longitudinal Study of Families and Health (MLSFH) is one of very few long-standing, publicly available longitudinal cohort studies in a sub-Saharan African (SSA) context. It provides a rare record of more than a decade of demographic, socioeconomic and health conditions in one of the world&rsquo;s poorest countries. The MLSFH was initially established in 1998 to study social network influences on fertility behaviours and HIV risk perceptions, and over time the focus of the study expanded to include health, sexual behaviours, intergenerational relations and family/household dynamics. The currently available data include MLSFH rounds collected in 1998, 2001, 2004, 2006, 2008, 2010 and 2012 for up to 4000 individuals, providing information about socioeconomic and demographic charac...
ART: Daily Vitamin D and Calcium Stave Off Bone LossART: Daily Vitamin D and Calcium Stave Off Bone Loss
Patients with HIV infection who take antiretroviral therapy can also reduce antiretroviral therapy-related bone loss by 50% by taking daily high-dose vitamin D and calcium supplements. Medscape Medical News (Source: Medscape Medical News Headlines)
Active clinician support, assistance are critical to successfully quitting smoking
While primary care providers' simply asking patients with high-risk smoking histories about their smoking status did not increase patients' likelihood of quitting, providing more direct assistance -- such as talking about how to quit, recommending or prescribing nicotine replacement or pharmaceutical aids, and following up on recommendations -- significantly improved patients' success in becoming smoke-free, investigators report. (Source: ScienceDaily Headlines)
Significant Drug Interactions in HIV-Infected PatientsSignificant Drug Interactions in HIV-Infected Patients
Drug-drug interactions are common in HIV-infected patients, and could represent major health problems. Which patients are most at risk? HIV Medicine (Source: Medscape Today Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Nigeria: Medical Practitioners Jointly Support Ambitious HIV Treatment Target
[This Day] Over twenty medical doctors from a range of specialisations have gathered in Abuja, Nigeria, to take part in a sensitisation workshop on the UNAIDS treatment target - the 90-90-90. (Source: AllAfrica News: HIV-Aids and STDs)
Depression and Oral FTC/TDF Pre-exposure Prophylaxis (PrEP) Among Men and Transgender Women Who Have Sex With Men (MSM/TGW)
Abstract We conducted a longitudinal and cross-sectional analysis of depressive symptomology in iPrEx, a randomized, placebo-controlled trial of daily, oral FTC/TDF HIV pre-exposure prophylaxis (PrEP) in men and transgender women who have sex with men. Depression-related adverse events (AEs) were the most frequently reported severe or life-threatening AEs and were not associated with being randomized to the FTC/TDF arm (152 vs. 144 respectively OR 0.66 95 % CI 0.35?1.25). Center for Epidemiologic Studies Depression scale (CES-D) and a four questions suicidal ideation scale scores did not differ by arm. Participants reporting forced sex at anal sexual debut had higher CES-D scores (coeff: 3.23; 95 % CI 1.24?5.23) and were more likely to have suicidal ideation (OR 2.2; 95 % C...
Parenting Mediates the Impact of Caregivers? Distress on Children?s Well-Being in Families Affected by HIV/AIDS

Uptake of Testing for HIV and Syphilis Among Men Who Have Sex with Men in Baltimore, Maryland: 2004?2011
Abstract Men who have sex with men (MSM) in Baltimore are at disproportionately high risk for HIV and syphilis infection. Testing and diagnosis are important first steps in receiving treatment and reducing transmission. We analyzed cross-sectional data collected in 2004?2005, 2008, and 2011 among MSM not reporting a previous positive HIV test (n = 1268) in Baltimore, Maryland as part of the National HIV Behavioral Surveillance System to determine the proportion of men tested for HIV and/or syphilis within the previous 12 months and examine the extent to which opportunities for testing were being missed in health care settings. Within the previous 12 months, 54 % of men had received an HIV test; 31 % had received a syphilis test; and only 23 % of men had received testing f...
South Africa: Basic Education On Draft HIV Policy
[SA Govt] The Department of Basic Education's Draft National Policy on HIV, STIs and TB came under close scrutiny during the 7th SA AIDS Conference held at the Durban International Convention Centre. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Malawi: Joneha Says Stigma, Discrimination Remains a Reality for Many People Living With HIV
[Malawi News Agency] Blantyre -Despite the laws and policies to protect people living with HIV, stigma and discrimination remains a reality for many people living with the virus in the country. (Source: AllAfrica News: HIV-Aids and STDs)
Botswana: NACA Hopes Dikgosi Join Aids Fight
[Botswana Daily News] Tlokweng -National Coordinating Agency (NACA) is putting its faith on dikgosi to help it to implement the new model to fight HIV/AIDS. (Source: AllAfrica News: HIV-Aids and STDs)
Malawi: Malawi Gets Over U.S $600 Million for HIV/Aids Fight
[Malawi News Agency] Johannesburg -United Nations AIDS agency (UNAIDS) has said Malawi is a model in the fight against AIDS whose credible efforts and successes prompted the Global Fund to release a total of over US$611 million which is US$37 million more than what the country applied for. (Source: AllAfrica News: HIV-Aids and STDs)
Tanzania: 'Zanzibar Needs to Do More to Achieve the HIV Three-Zeros'
[Daily News] Zanzibar -The legislator Mr Saleh Nassor Juma (CUF-Wawi), has said that authorities in Zanzibar need to do more should the need to get to the three-zeros: Zero New HIV Infections, Zero Discrimination and Zero AIDS-Related Deaths. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: Parents Resort Herbal Drugs to Treat HIV Children
[Guardian] LEFT with no other option as government has failed to make human immunodeficiency virus / acquired immune deficiency syndrome (HIV/AIDS) drugs available in facilities across Taraba State for children living with HIV, parents have started seeking the help of herbal medicine practitioners to treat their children. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Active clinician support and assistance are critical to successfully quitting smoking
(Massachusetts General Hospital) A new study from a Massachusetts General Hospital research team finds that, while primary care providers' simply asking patients with high-risk smoking histories about their smoking status did not increase patients' likelihood of quitting, providing more direct assistance -- such as talking about how to quit, recommending or prescribing nicotine replacement or pharmaceutical aids, and following up on recommendations -- significantly improved patients' success in becoming smoke-free. (Source: EurekAlert! - Social and Behavioral Science)
Disseminated Infections with Talaromyces marneffei in Non-AIDS Patients Given Monoclonal Antibodies against CD20 and Kinase Inhibitors
J. Chan et al. (Source: Emerging Infectious Diseases Journal)
Relationships between Serum Levels of Atazanavir and Renal Toxicity or Lithiasis.
Authors: Marinescu CI, Leyes M, Ribas MA, Peñaranda M, Murillas J, Campins AA, Martin-Pena L, Barcelo B, Barceló-Campomar C, Grases F, Frontera G, Riera Jaume M Abstract The main aim of this study is to describe the relationship between serum levels of atazanavir, renal toxicity, and lithiasis. This is a prospective observational study of patients being treated with atazanavir (ATV) at Son Espases Teaching Hospital, Palma de Mallorca, between 2011 and 2013. The study includes 98 patients. Sixteen were found to have a history of urolithiasis. During a median monitoring period of 23 months, nine patients suffered renal colic, in three of whom ATV crystals were evidenced in urine. Cumulative incidence of renal colic was 9.2 per 100 patients. The variables related to having renal col...
Monitoring and Evaluating Transition and Sustainability of donor-funded programs: Reflections on the Avahan experience
Conclusions Given the scarceness of transition evaluations, the lessons from this evaluation may have widespread relevance. (Source: Evaluation and Program Planning)
Consonant discrimination by Mandarin-speaking children with prelingual hearing impairment
Little is known about the consonant discrimination ability of Mandarin-speaking children with prelingual hearing impairment (HI) and fitted with hearing aids (HAs). The present study aimed to evaluate Mandarin consonant discrimination ability in children with HI, and explore the effects of unaided and aided hearing threshold, the age of first HA fitting and the duration of HA use on consonant discrimination ability. (Source: International Journal of Pediatric Otorhinolaryngology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Risk perception of sexually transmitted infections and HIV in Nigerian commercial sex workers in Barcelona: a qualitative study
Conclusions Nigerian CSWs are a vulnerable group because of their poor socioeconomic status. The perception of risk in this group and their preventive behaviours are based on personal determinants, beliefs and experiences from their home country and influences from the host country. Interventions aimed at CSWs must address knowledge gaps, risk behaviours and structural elements. (Source: BMJ Open)
Presence with purpose: attitudes of people with developmental disability towards health care students
ConclusionsPeople with DD are affected by above?average health care needs. Their input into health care planning has been limited. Their opinions on health care learners varied considerably. Themes relating to attitudes, comfort and preferences about student involvement provide impetus for health care training practices that promote person?centred approaches and improvements to the quality of care received by people with DD. (Source: Medical Education)
PRINCE-1: safety and efficacy of atazanavir powder and ritonavir liquid in HIV-1-infected antiretroviral-naïve and -experienced infants and children aged ?3 months to
CONCLUSIONS: ATV powder boosted with RTV liquid once daily plus optimized dual NRTI background therapy was effective and well tolerated in this ART-naïve or -experienced paediatric population aged ?3 months to &lt;6 years. No unexpected safety findings compared with those from previous ATV paediatric and adult studies were identified. PMID: 26066346 [PubMed - as supplied by publisher] (Source: Journal of the International AIDS Society)
Malawi: Mutharika Says Malawi to Eradicate HIV/Aids By 2030
[Nyasa Times] Johannesburg -Malawian President Prof. Arthur Peter Mutharika and his government has been hailed for demonstrating high level commitment in the national and global fight against HIV and AIDS. (Source: AllAfrica News: Health and Medicine)
Success of a Mentor Mother Equals Success of the Greater Community
When Bessie Nkhwazi, the mothers2mothers (m2m) Malawi District Manager for Thyolo District, told me that Thekerani Health Center was "very far away," I did not think much of it. I have visited plenty of health facilities labeled "very far" during my time as a Global Health Corps Fellow in Malawi, but after almost two hours in the car on a precarious, mountain-top dirt road, I fully understood why Bessie emphasized "very far." When we finally arrived, we were greeted by Charity Chiteuwe, the m2m Site Coordinator at Thekerani Health Center. Charity runs the m2m program at Thekerani, which opened in November of 2013. Charity and her fellow Mentor Mothers provide education and peer support to HIV+ women, working to ensure that they access treatment early and stay in care to protect their bab...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Canalicular laceration repair using a viscoelastic injection to locate and dilate the proximal torn edge
Conclusions Deploying viscoelastic superficially near, and injecting into the injured canaliculus can improve visualization of the operative field by retracting the surrounding tissue and tamponading any bleeding, which aids in location and dilation of the torn canaliculus initially and in subsequent steps, eases intubation into the lubricated torn canaliculus and nasolacrimal duct, and avoids iatrogenic injury to an uninjured canaliculus. (Source: Journal of American Association for Pediatric Ophthalmology and Strabismus)
Are long-lasting insecticide-treated bednets and water filters cost-effective tools for delaying HIV disease progression in Kenya?
CONCLUSIONS: Provision of LLIN and WF could be a cost-saving and practical method to defer time to ART eligibility in the context of highly resource-constrained environments experiencing donor fatigue for HIV/AIDS programs. PMID: 26065636 [PubMed - as supplied by publisher] (Source: Global Health Action)
South Africa: Drug Shortages Threaten HIV Fight
[MSF] Johannesburg - A new survey released today shows that shortages of essential HIV and tuberculosis medicines in most South African provinces are a systematic obstacle to the success of the largest antiretroviral treatment program in the world, said the civil society organisation Stop Stock Outs Project during the South Africa AIDS Conference currently underway in Durban. (Source: AllAfrica News: Health and Medicine)
Misclassification of Men with Reported HIV Infection in Ukraine
Abstract We analyzed data on reported mode of transmission in case reports of HIV-infections among men in Ukraine. The number of men who were reported to have acquired HIV through heterosexual transmission increased substantially in 2006?2011. However, we estimate that up to 40 % of reported cases of heterosexual transmission among men may actually represent misclassified men who have sex with men or persons who inject drugs. These findings indicate a need to improve the quality of data on reported mode of HIV transmission. Accurate information has important public health implications in planning prevention and treatment services. (Source: AIDS and Behavior)
Nomograms for Predicting Outcomes after Chemoembolization in Patients with Nonmetastatic Hepatocellular Carcinoma
Conclusion Nomograms quantifying the survival and progression outcomes in patients treated with transarterial chemoembolization are useful clinical aids in providing personalized care. (Source: Journal of Vascular and Interventional Radiology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Trends in prevalence of diarrhoea, Kaposi&#8217;s sarcoma, bacterial pneumonia, malaria and geohelminths among HIV positive individuals in Uganda
The objective of this study was to describe the trends in prevalence of Diarrhoea, Bacterial pneumonia, Kaposi?s sarcoma, Malaria and Geohelminths among HIV positive individuals over a 12 year period in Uganda. Methods: Observation data for 5972 HIV positive individuals enrolled with the AIDS support organisation (TASO) in Uganda were analysed. Study participants were drawn from three HIV clinics located in different geographical areas of Uganda and followed from January 2002 to December 2013. The prevalence trends for the above OIs were plotted using the Box Jenkins moving average technique. X 2-test for trend was used to test for the significance of the trends and Pearson?s correlation coefficient used to test for the strength of linear relationship between OI pr...
HIV-infected people in Sudan moving toward chronic poverty: Possible interventions
We sought to identify the socioeconomic impact on people living with HIV (PLWH) in Sudan. Focus group discussions were used to collect data and identify the most outstanding domains of HIV impact on PLWH and the survival mechanisms that may be common to a group of diverse HIV-infected persons (n=30). The findings indicated the most striking financial and social impacts were due to stigma associated with HIV in the conservative Sudanese society, which lead to loss of work with all its consequences (e.g.,children?s education and health care expenses were affected).The socioeconomic impacts of HIV on infected populations are discussed and suggestions for possible interventions to mitigate harmful impacts and stigma within the society, the workplace, and healthcare settings are highlighted. ...
?: Experiences accessing HIV care and adhering to medications after incarceration
Most HIV-infected inmates leave prison with a suppressed viral load; many, however, become disconnected from care and non-adherent to medications during reentry to community life. In this secondary data analysis of focus groups (N = 6) and in-depth interviews (N = 9) with 46 formerly incarcerated HIV-infected people during reentry, we used an inductive analytic approach to explore the interplay between individual, interpersonal, community, and structural factors and HIV management. Participants described barriers and facilitators to care engagement and adherence at each of these 4 levels, as well as a milieu of HIV and incarceration-related stigma and discrimination. (Source: Journal of the Association of Nurses in AIDS Care)
Management practices to support donor transition: lessons from Avahan, the India AIDS Initiative
Conclusions: In the Avahan case a number of management practices supported a smooth transition these included: an extended and sequenced time frame for transition; co-ownership and planning of transition by both donor and government; detailed transition planning and close attention to program alignment, capacity development and communication; engagement of staff in the transition process; engagement of multiple stakeholders post transition to promote program accountability and provide financial support; signaling by actors in charge of transition that they were committed to specified time frames. (Source: BMC Health Services Research)
Jointly Modeling Event Time and Skewed-Longitudinal Data with Missing Response and Mismeasured Covariate for AIDS Studies
(Source: Journal of Biopharmaceutical Statistics)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Ten Things You Can Do For National HIV Testing Day
CDC's Division of HIV/AIDS suggests actions you can take for National HIV Testing Day to help raise awareness on the importance of HIV prevention and testing. (Source: CDC HIV/AIDS Prevention)
A model-based cost-effectiveness analysis of a grommets-led care pathway for children with cleft palate affected by otitis media with effusion
This study found some evidence that the insertion of grommets to manage cleft palate children with bilateral OME is likely to be cost-effective, but further research is required to inform this treatment choice. (Source: The European Journal of Health Economics)
Zambia: 'Boarding Houses Boost HIV Infections'
[Times of Zambia] Kitwe District AIDS coordination advisor has attributed the high HIV/AIDS infection rate in the district to the mushrooming boarding houses. (Source: AllAfrica News: HIV-Aids and STDs)
Linkage to care following a home-based HIV counselling and testing intervention in rural South Africa.
CONCLUSIONS: The findings highlight barriers to linkage following an increasingly popular model of HIV testing. Further, they draw attention to ways in which practical interventions and health education strategies could be used to improve linkage to care. PMID: 26058983 [PubMed - in process] (Source: Journal of the International AIDS Society)
Risk factors for pre-term birth in a Canadian cohort of HIV-positive women: role of ritonavir boosting?
CONCLUSION: While previous studies on the association between PTB and PI use have generally considered all PIs the same, our results would indicate a possible role of ritonavir boosting as a risk factor for PTB. Further work is needed to understand the pathophysiologic mechanisms involved, and to identify the safest ARV regimens to be used in pregnancy. PMID: 26051165 [PubMed - in process] (Source: Journal of the International AIDS Society)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Examining Delay Discounting of Condom-Protected Sex Among Men Who Have Sex with Men Using Crowdsourcing Technology
Abstract Some men who have sex with men (MSM) have unprotected anal intercourse (UAI) in situations that put them at risk for HIV infection despite having the knowledge and skills to avoid these risks. The present study examined the potential role of delay discounting in sexual HIV risk behavior among MSM. Participants (n = 108) completed the Sexual Discounting Task and a questionnaire regarding UAI and other variables associated with HIV risk (e.g., age, socioeconomic status, substance use, psychiatric problems). MSM discounted the value of condom-protected anal intercourse in a manner that was orderly, hyperbolic, and sensitive to partner characteristics that likely influence realworld decisions about using condoms. Steeper discounting was associated with UAI, and other factor...
Risk factors for early mortality after AIDS in the cART era: A population-based cohort study in Italy
This study aimed to estimate, at a population level, the survival experience of Italian people with AIDS (PWA) and to quantify the prognostic role of selected factors at diagnosis in the risk of early mortality (i.e., within six months from AIDS diagnosis). Methods: A population-based, retrospective-cohort study was conducted among Italian PWA diagnosed between 1999 and 2009 and recorded in the national AIDS registry. The vital status, up to December 2010, of 14,552 PWA was ascertained through a record linkage procedure with the Italian mortality database. Survival probabilities were estimated through Kaplan-Meier method. To identify risk factors for early mortality from any cause, odds ratios (ORs) and corresponding 95 % confidence intervals (CIs), adjusted for major confounders, were c...
Paper or plastic? Simulation based evaluation of two versions of a cognitive aid for managing pediatric peri-operative critical events by anesthesia trainees: evaluation of the society for pediatric anesthesia emergency checklist
In this study, we evaluated user preferences for a CA (SPA checklist) using two different presentation formats, paper and electronic, during management of simulated critical events. Anesthesia trainees managed the simulated critical events under one of three randomized conditions: (1) memory alone, (2) with a paper version of the CA, (3) with an electronic version of the CA. Following participation in the simulated critical events, participants were asked to complete a survey regarding their experience using the different versions of the CA. The percentage of favorable responses for each format of the CA was compared using a mixed effects proportional odds model. There were 143 simulated events managed by 89 anesthesia trainees. Approximately one out of three trainees (electronic 29 %, pa...
HIP osteoarthritis and work
Publication date: Available online 10 June 2015 Source:Best Practice &amp; Research Clinical Rheumatology Author(s): E. Clare Harris , David Coggon Epidemiological evidence points strongly to a hazard of hip osteoarthritis from heavy manual work. Harmful exposures may be reduced by the elimination or redesign of processes and the use of mechanical aids. Reducing obesity might help to protect workers whose need to perform heavy lifting cannot be eliminated. Particularly high relative risks have been reported in farmers, and hip osteoarthritis is a prescribed occupational disease in the UK for long-term employees in agriculture. Even where it is not attributable to employment, hip osteoarthritis impacts importantly on the capacity to work. Factors that may influence work participation ...
[In Depth] HIV family trees reveal viral spread
New genetic studies that compare different HIV isolates with each other are allowing researchers to create sophisticated maps of transmission networks. These phylogenetic transmission maps, in turn, are pinpointing where prevention efforts can get the most bang for their buck. A meeting held at the New York Academy of Sciences in New York City on 4 June gathered researchers, representatives from public health organizations, and HIV/AIDS advocates to discuss the latest studies in this emerging field, which revealed several surprising findings about HIV's spread in many different geographic regions around the world. The meeting participants also discussed at length the ethical and legal dilemmas raised by such research, which even though it does not specify who infected whom might be misused...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Development and evaluation of an online tool for management of overweight children in primary care: a pilot study
Conclusions The results of this pilot study indicate that an online tool for assessment and management of childhood obesity can be implemented in primary care, and is acceptable to patients, families and practitioners. Further development and evaluation of the tool is warranted. (Source: BMJ Open)
Natural sequence of recovery from child post-traumatic amnesia: A retrospective cohort study.
Authors: Briggs R, Birse J, Tate R, Brookes N, Epps A, Lah S Abstract The aim of this study was to determine the sequence of skills recovery during post-traumatic amnesia (PTA) in children with moderate to severe traumatic brain injuries (TBIs). SETTING: Fifty children aged 8 to 15 years consecutively admitted to a children's hospital with TBI and PTA&gt;24 were tested in a retrospective cohort study where the main measure was the Westmead PTA Scale (WPTAS). The group analyses show that orientation to time took longer to recover than orientation to person and place, but not memory, while the individual analyses revealed that when orientation to time was grouped with memory, 94% of children recovered orientation to person and place before orientation to time and memory (examiner...
Geo-demography of HIV/AIDS in Japan from 1985 to 2011 - Incidence and transmission mode under influence of population size/density.
Authors: Yoshikura H Abstract A stable relation was found between number of HIV/AIDS (P) and population size (N) and between incidence of HIV/AIDS (I) and population density (D). The relation could be expressed as P=kN(m) or I=hD(n), where k, h, m and n are constants. For "AIDS"/"AIDS diagnosis", the constant m was 1.5 for Japan and 1.3 for USA, and n was 0.38 both for Japan and USA. These observations indicated that the larger the population size the larger the number of HIV/AIDS patients disproportionately, and the denser the population the higher the incidence of HIV/AIDS disproportionately. Considering the wide geo-demographic difference between the two countries, it was striking that the same equations with constants within a narrow range were applicable to Japan and USA. Mode...
Adverse drug reactions in hiv/aids patients at a tertiary care hospital penang, malaysia.
ADVERSE DRUG REACTIONS IN HIV/AIDS PATIENTS AT A TERTIARY CARE HOSPITAL PENANG, MALAYSIA. Jpn J Infect Dis. 2015 Jun 12; Authors: Khan K, Khan AH, Sulaiman SA, Soo CT, Akhtar A Abstract Current study is aimed to explore and observe adverse drug reactions occurrence of antiretroviral therapy among HIV/AIDS patients.An observational retrospective study of all patients on HAART therapy diagnosed with HIV infection from Jan 2007 to Dec 2012 was conducted at Hospital Pulau Pinang, Malaysia. Patient socio-demographic details along with clinical features and susceptible ADRs were observed during the study period.Out of 743 patients 571 (76.8%) were male and 172 (23.1%) were female. Overall 314 (42.2%) patients had experienced adverse drug reactions. A total number of 425 (57....
Some people can resist the ravages of HIV ? here's how
About 1 per cent of people with HIV can suppress the virus without drugs, perhaps because a part of their immune system mounts an effective last-ditch response (Source: New Scientist - HIV and AIDS)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Government scraps import duties on AIDS drugs to battle shortage
More than a third of India's 2.1 million HIV/AIDS patients depend on getting their daily antiretrovirals for free. (Source: The Economic Times Healthcare and Biotech News)
South Africa: Woman Screams HIV to Stop Rape
[News24Wire] The owner of a Thai massage and spa parlour in Durban averted certain sexual assault after she told her attackers that she was HIV-positive, police said on Wednesday. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: UNAIDS Laments Inadequacy of Funds Earmarked for HIV/Aids
[This Day] Abuja -The United Nations AIDS agency (UNAIDS) has said funds earmarked by the Nigerian Government for treatment of HIV/AIDS in the country are not enough to stop further spread of the virus. (Source: AllAfrica News: HIV-Aids and STDs)
India scraps import duties on AIDS drugs to battle shortage
MUMBAI (Reuters) - India has scrapped customs import duties for drugs and test kits used to treat AIDS in an effort to cut prices across the country, as it struggles to cope with an ongoing shortage in its national program to fight the disease. (Source: Reuters: Health)
Africa: Women and Girls in Africa 'Being Left Behind' in Fight Against HIV/Aids - UN Report
[UN News] Despite considerable advances made in the global response to the AIDS epidemic over the last several decades, young women and adolescent girls in Africa "are still being left behind," according to a new joint report from the United Nations and the African Union. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
South Africa: Deputy President Cyril Ramaphosa Launches National HIV and TB Stigma Reduction Interventions
[SA Govt] Deputy President, Cyril Ramaphosa together with KwaZulu-Natal Premier Senzo Mchunu, officially launched the national HIV and TB Stigma Reduction Interventions in Durban today. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: New Approach On HIV Viral Load Testing
[Global Fund] Geneva -Framework agreements will be established between the Global Fund and seven diagnostic manufacturers which aim to make the market for HIV viral load testing more transparent and competitive, driving cost reductions of up to one third. (Source: AllAfrica News: HIV-Aids and STDs)
South Africa: HIV Stigma - the Great, Unspoken Issue
[Daily Maverick] Confronting stigma is at the heart of tackling the country's HIV/Aids challenges. For the first time, a new survey sheds light on issues of internal and external stigma. The state now needs to turn the results into policy initiative because, simply, stigma is killing people. By GREG NICOLSON. (Source: AllAfrica News: HIV-Aids and STDs)
South Africa: SA Needs to Reduce Rate of HIV Transmission
[SAnews.gov.za] South Africa needs to reduce the rate of HIV transmission amongst its youth, says Deputy President Cyril Ramaphosa. (Source: AllAfrica News: HIV-Aids and STDs)
South Africa: South Africa Reflects On Battle to Curb HIV and Aids
[SA Info] South Africa had turned the tide on HIV, Deputy President Cyril Ramaphosa said in opening the seventh SA Aids Conference yesterday. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Value added: functional MR imaging in management of bone and soft tissue sarcomas
Purpose of review: MRI plays a crucial role in the initial diagnosis, treatment planning, and long-term management of bone and soft tissue sarcomas. Technological advances have enabled improvements in both delineation of anatomic detail, and in functional imaging techniques that interrogate tissues at the cellular level. This bears particular relevance in sarcomas as morphological parameters alone do not necessarily correlate with treatment response and prognosis. Here, we describe recent developments in advanced MRI techniques, including chemical-shift MRI, diffusion-weighted imaging (DWI), MR spectroscopy (MRS), and dynamic contrast enhanced (DCE) MRI. Recent findings: Chemical-shift MRI allows robust discrimination of marrow infiltrating neoplasms from benign red marrow. DWI reveals tum...
Nigeria: NACA Dismisses Report On HIV/Aids Accounting for 59.3 Percent of Female Deaths
[Guardian] The National Agency for the Control of AIDS (NACA) has dismissed report in one of the national dailies, not The Guardian Newspapers, which quoted a National Bureau of Statistics Report titled "Statistical Report on Women and Men in Nigeria" that said "Human Immuno-deficiency Virus (HIV)/Acquired Immune Deficiency Syndrome (AIDS) accounted for 59.3 percent of female deaths recorded in Nigeria for four years between 2010-2013." (Source: AllAfrica News: HIV-Aids and STDs)
Skeletal muscle atrophy: Potential therapeutic agents and their mechanisms of action
Publication date: September 2015 Source:Pharmacological Research, Volume 99 Author(s): Vikas Dutt , Sanjeev Gupta , Rajesh Dabur , Elisha Injeti , Ashwani Mittal Over the last two decades, new insights into the etiology of skeletal muscle wasting/atrophy under diverse clinical settings including denervation, AIDS, cancer, diabetes, and chronic heart failure have been reported in the literature. However, the treatment of skeletal muscle wasting remains an unresolved challenge to this day. About nineteen potential drugs that can regulate loss of muscle mass have been reported in the literature. This paper reviews the mechanisms of action of all these drugs by broadly classifying them into six different categories. Mechanistic data of these drugs illustrate that they regulate skeletal muscl...
Immunogenicity and Safety of 13-Valent Pneumococcal Conjugate Vaccine in HIV-Infected Adults Previously Vaccinated With Pneumococcal Polysaccharide Vaccine
Conclusions.&nbsp;Vaccination with PCV13 induces anticapsular immunoglobulin G and opsonophagocytic antibody responses in HIV-infected adults with prior PPSV23 vaccination and CD4 cell counts &ge;200 cells/mm3. The observations support the use of PCV13 in this population. Clinical Trials Registration.&nbsp;NCT00963235. (Source: The Journal of Infectious Diseases)
Assessing the Paradox Between Transmitted and Acquired HIV Type 1 Drug Resistance Mutations in the Swiss HIV Cohort Study From 1998 to 2012
Conclusions.&nbsp;Transmission of antiretroviral drug resistance is temporarily reduced by the introduction of new drug classes and driven by nonresponding and treatment-naive patients. These findings suggest a continuous need for new drugs, early detection/treatment of HIV-1 infection. (Source: The Journal of Infectious Diseases)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Early Antiretroviral Therapy in South African Children Reduces HIV-1-Infected Cells and Cell-Associated HIV-1 RNA in Blood Mononuclear Cells
We measured cell-associated human immunodeficiency virus (HIV)-1 DNA (CAD) and RNA (CAR) and plasma HIV-1 RNA in blood samples from 20 children in the Children with HIV Early Antiretroviral (CHER) cohort after 7&ndash;8 years of suppressive combination antiretroviral therapy (cART). Children who initiated cART early (&lt;2 months; n = 12) had lower HIV-1 CAD (median, 48 vs 216; P &lt; .01) and CAR (median, 5 vs 436; P &lt; .01) per million peripheral blood mononuclear cells than children who started later (&ge;2 months; n = 8). Plasma HIV-1 RNA levels were not significantly lower in early-treated children (0.5 vs 1.2 copies/mL; P = .16). Early treatment at &lt;2 months of age reduces the number of HIV-infected cells and HIV CAR. (Source: The Journal of Infectious Diseases)
Immediate T-Helper 17 Polarization Upon Triggering CD11b/c on HIV-Exposed Dendritic Cells
Early on in human immunodeficiency virus (HIV) type 1 infection, gut T-helper (Th) 17 cells are massively depleted leading eventually to compromised intestinal barrier function and excessive immune activation. In contrast, the functional Th17 cell compartment of the gut is well-maintained in nonpathogenic simian immunodeficiency virus infection as well as HIV-1 long-term nonprogressors. Here, we show that dendritic cells (DCs) loaded with HIV-1 bearing high surface complement levels after incubation in plasma from HIV-infected individuals secreted significantly higher concentrations of Th17-polarizing cytokines than DCs exposed to nonopsonized HIV-1. The enhanced Th17-polarizing capacity of in vitro&ndash;generated and BDCA-1+ DCs directly isolated from blood was linked to activation of ER...
Dynamic Visual Display of Treatment Response in HIV-Infected Adults
Conclusions.&nbsp;The dramatic changes in viral load and CD4 cell count after therapy initiation highlight the overwhelming effectiveness of antiretroviral therapy in the modern era. However, this work also emphasizes the need for pharmaceutical or behavioral interventions to prevent virologic failure and to stimulate complete recovery of normal CD4 cell count. (Source: Clinical Infectious Diseases)
Treatment Failure in HIV-Infected Children on Second-line Protease Inhibitor-Based Antiretroviral Therapy
Conclusions.&nbsp;Children with longer exposure to first-line ART, entry to adolescence, underweight, and/or undetectable drug levels were at higher risk of failing second-line ART and thus should be closely monitored. (Source: Clinical Infectious Diseases)
Concurrent Anemia and Elevated C-Reactive Protein Predicts HIV Clinical Treatment Failure, Including Tuberculosis, After Antiretroviral Therapy Initiation
Conclusions.&nbsp;ART-naive, HIV-infected individuals with concurrent anemia and inflammation are at particularly high risk of failing treatment, and understanding the pathogenesis could lead to new interventions. Reducing inflammation and anemia will likely improve HIV disease outcomes. Alternatively, concurrent anemia and inflammation could represent individuals with occult opportunistic infections in need of additional screening. (Source: Clinical Infectious Diseases)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Treatment to Prevent HIV Transmission in Serodiscordant Couples in Henan, China, 2006 to 2012
Conclusions.&nbsp;ART can provide HIV-infected persons in resource-limited setting substantial protection against sexual transmission. Effectiveness in the Henan cohort appears to have increased over time, suggesting that quality of care and service infrastructure may be integral to successful use of treatment for prevention. (Source: Clinical Infectious Diseases)
Proof-of-Principle for Immune Control of Global HIV-1 Reactivation In Vivo
Conclusions.&nbsp;These observations provide evidence that the human immune response is capable of controlling coordinated global HIV-1 reactivation, remarkably with potency equivalent to combination antiretroviral therapy. These data will inform design of vaccines for use in HIV-1 curative interventions. (Source: Clinical Infectious Diseases)
Cost-effectiveness of a repeat HIV test in pregnancy in India
Conclusions Our results warrant consideration at the national level for including a second HIV test of all pregnant women in the national programme. However prior to allocation of resources for a second HIV test in pregnancy, appropriate strategies will have to be planned for improving compliance for prevention of mother-to-child transmission of HIV and reducing loss-to-follow-up of those women detected with HIV. Trial registration number CTRI/2013/12/004183. (Source: BMJ Open)
Cytokine polymorphisms and plasma levels are associated with sleep onset insomnia in adults living with HIV/AIDS
This study strengthens the evidence for an association between inflammation and sleep disturbance, particularly self-report of habitual SOI. In this chronic illness population, the cytokine polymorphisms associated with SOI provide direction for future personalized medicine intervention research. (Source: Brain, Behavior, and Immunity)
Anaphylaxis as a cause of hospitalization - a single academic centre experience.
CONCLUSIONS: It is difficult to forecast the course of the reaction based on the causative factor, for anaphylactic reaction is characterised by a great individual changeability and intensity of the first symptoms. PMID: 26050978 [PubMed - in process] (Source: Pneumonologia i Alergologia Polska)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
'Sirius' About Overcoming Obstacles to Healthy Eating
I was pleased to join NYU's Samantha Heller this past Friday on the Doctor Radio channel on SiriusXM Radio (Channel 81). Samantha and I had previously shared airtime on CureTalks web radio, discussing Making Good Food Choices in an Urban Environment. This past Friday, we talked more generally about overcoming obstacles to healthy eating. As one topic, we covered how food need not be expensive to be healthy, a point I also make (with references) in a recent co-authored paper on Nutrition Myths. Making that same point at-a-glance--comparing prices of healthier vs. less-healthy food -- is a powerful infographic from years ago in the The New York Times. There is also a case to be made for not wasting money elsewhere (e.g., smoking) so that more money can be available for healthier food. But ...
Women and girls in Africa ?being left behind? in fight against HIV/AIDS ? UN report
Despite considerable advances made in the global response to the AIDS epidemic over the last several decades, young women and adolescent girls in Africa ?are still being left behind,? according to a new joint report from the United Nations and the African Union. (Source: UN News Centre - Health, Poverty, Food Security)
Government exempts AIDS drugs from customs duty
The exemption will benefit Anti-Retroviral Drugs (ARV Drugs) -- Adult First Line, Adult Second Line and Paediatric Drugs. (Source: The Economic Times Healthcare and Biotech News)
Improving Human Immunodeficiency Virus/AIDS Palliative Care in Critical Care
This study examines the effects of an educational intervention addressing palliative care in the intensive care unit and the needs of the HIV/AIDS patients and families. The study will evaluate the critical care nurses? knowledge and competence in caring for this population following the educational sessions. Methods: Thirty critical care nurses were recruited from the critical care unit at a hospital in the south. An HIV/AIDS palliative care course provided participants background knowledge, general principles, and opportunities for critical thinking regarding palliative care. A pretest and posttest on palliative care were provided to each subject to assess knowledge and confidence in palliative care in critical care nursing. Results: The convenience sample of 30 nurses attained a mean ...
The Challenges of the HIV Continuum of Care in the U.S.The Challenges of the HIV Continuum of Care in the U.S.
How are the CDC, federal partners, public health departments and others working to inform and improve outcomes along the HIV care continuum? JAIDS: Journal of Acquired Immune Deficiency Syndromes (Source: Medscape Today Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Implementation challenges for long-acting antivirals as treatment
Purpose of review: Long-acting injectable antiretroviral therapy (ART) formulations hold great promise in helping to close the significant gap between efficacy and effectiveness in HIV treatment by eliminating the requirement for lifelong daily pills. However, significant systems-level and individual challenges to implementation of long-acting ART in HIV treatment are anticipated. Recent findings: Studies of long-acting ART formulations are burgeoning, but the drugs are still in early phases of investigation and key knowledge gaps in pharmacokinetics and pharmacodynamics, as well as their effectiveness in settings with the largest burden of HIV disease and in key populations, remain. Extrapolating from the literature on implementation barriers to using long-acting contraception on a global...
Planning ahead for implementation of long-acting HIV prevention: challenges and opportunities
Purpose of review: Broad-based access, uptake, and dissemination of daily oral HIV preexposure prophylaxis (PrEP) have been slow, despite strong evidence for efficacy. Effective and efficient implementation of long-acting HIV prevention products will require both analysis of the dynamics and determinants of daily oral PrEP implementation and identification of the distinct challenges and opportunities inherent in emerging technologies. Recent findings: Evidence suggests the importance of addressing implementation issues at three levels: patient, provider, and system. Patient-level factors include targeted education and messaging, tailored supports to enhance acceptability and uptake, and effective strategies for promoting adherence/persistence and retention in care. Provider-level factors i...
Injectable agents for pre-exposure prophylaxis: lessons learned from contraception to inform HIV prevention
Purpose of review: Long-acting injectable (LAI) forms of preexposure prophylaxis (PrEP) are in clinical trials, generating much hope for HIV prevention. But this is not the first time that an injectable form of preventive medication has emerged: the contraceptive agent depomedroxyprogesterone acetate (DMPA) has an important precedent. DMPA's long journey, its initial reception, and ongoing implementation challenges can help inform the field of HIV prevention as we plan for approval, acceptance, and scale-up of LAI-PrEP. Recent findings: DMPA faced a long regulatory journey in the USA, with a lag of 25 years from initial application (1967) to approval (1992). Acceptance after introduction was rapid, but challenges hampered scale-up. Specific lessons learned include that extensive acceptabil...
Regulatory challenges in developing long-acting antiretrovirals for treatment and prevention of HIV infection
Purpose of review: To outline some of the regulatory challenges inherent to the development of long-acting antiretrovirals (ARVs) for the treatment or prevention of HIV infection. Recent findings: Despite advances in drug development that have reduced ARV dosing to once daily, suboptimal drug adherence remains an obstacle to successful HIV treatment. Further, large randomized trials of once daily oral ARVs for preexposure prophylaxis (PrEP) have shown that drug adherence correlates strongly with prophylactic effect and study outcomes. Thus, the prospect of developing long-acting ARVs, which may mitigate drug adherence issues, has attracted considerable attention lately. Summary: Because of their pharmacokinetic properties, the development of long-acting ARVs can present novel regulatory ch...
Recent work on vaginal rings containing antiviral agents for HIV prevention
Purpose of review: In response to the need for strategies women can use to protect themselves from HIV infection, a new class of product commonly referred to as vaginal ?microbicides? has been under development for the past few decades. Several leading products currently in development contain antiviral agents delivered in a vaginal ring. Recent findings: Research published over the past year reports advances in identification and continued formulation of specific antiviral agents that have potential for delivery in vaginal rings, including drug combinations for HIV, other sexually transmitted infections and contraception. Most products are antiretroviral reverse transcriptase inhibitors. Advances in vaginal ring design have also been reported; some of these are designed to release spe...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Cabotegravir long-acting for HIV-1 prevention
Purpose of review: Preexposure prophylaxis (PrEP) with daily Truvada has demonstrated clinical efficacy against HIV-1 acquisition that correlates with high adherence. Long-acting antiretroviral drugs offer an alternative to daily regimens and may improve PrEP adherence. This review summarizes the preclinical nonhuman primate studies for evaluating the efficacy of cabotegravir long-acting as PrEP and the ongoing phase 2a studies assessing safety, tolerability, and acceptability of cabotegravir long-acting. Recent findings: Cabotegravir is an HIV-1 integrase strand transfer inhibitor with intrinsic properties that permit its formulation as a long-acting injectable suspension. In clinical evaluation, cabotegravir long-acting has a half-life that permits infrequent dosing, possibly once every ...
Long-acting rilpivirine for HIV prevention
Purpose of review: Long-acting injectable antiretroviral (ARV) formulations are being developed for the treatment and prevention of HIV infection. The purpose of this review is to summarize recent preclinical and clinical data on TMC278 (rilpivirine), a nonnucleoside reverse transcriptase inhibitor (NNRTI), that is being developed for both a treatment and prevention indication. Recent findings: Long-acting rilpivirine has demonstrated efficacy in preventing HIV acquisition in a humanized mouse model and has been found to be well tolerated and acceptable in several Phase I clinical trials. Pharmacokinetic data from Phase I studies suggest that 1200?mg of long-acting rilpivirine administered every 8 weeks would be associated with plasma and tissue levels of rilpivirine anticipated to be ne...
Formulation and pharmacology of long-acting cabotegravir
Purpose of review: Long-acting cabotegravir may provide a novel therapeutic option for both the treatment and prevention of HIV-1 infection that does not necessitate adherence to a daily regimen. The present review will highlight the unique formulation properties and pharmacologic attributes of long-acting cabotegravir nanosuspension. Recent findings: Cabotegravir is a potent integrase strand transfer inhibitor that has been formulated as an oral tablet for daily administration and as a long-acting injectable nanosuspension. Long-acting cabotegravir is readily absorbed following intramuscular and subcutaneous administration and has an elimination half-life of approximately 40 days, allowing for administration on a monthly or less frequent schedule. Repeat-dose pharmacokinetic studies and p...
Long-acting antiviral agents for HIV treatment
Purpose of review: Long-acting antiretroviral (ARV) agents are currently under development for the treatment of chronic HIV infection. This review focuses on data recently produced on injectable ARVs for patients living with HIV/AIDS and on the patients? perspectives on the use of these agents. Recent findings: Crystalline nanoparticle formulations of the nonnucleoside reverse transcriptase inhibitor rilpivirine (TMC278) and of the HIV-1 integrase strand transfer inhibitor cabotegravir (GSK1265744) have progressed into phase II clinical trials as injectable maintenance therapy for patients living with HIV/AIDS with an undetectable viral load. Summary: Phase II studies evaluating the coadministration of rilpivirine and cabotegravir intramuscularly to HIV-infected individuals with an undet...
Formulation and pharmacology of long-acting rilpivirine
Purpose of review: Rilpivirine (RPV), a nonnucleoside reverse transcriptase inhibitor, is a potent antiretroviral (ARV) effective for HIV treatment at 25?mg daily oral dose. Its physio-chemical and pharmacological properties enable formulation of RPV as a long-acting injectable nanosuspension. This review summarizes these properties supporting the potential of intermittent parenteral administration of rilpivirine long acting (RPV LA) in both treatment and prevention of HIV-1 infection. Recent findings: RPV is unusual among ARVs in that its stability and solubility enable aqueous suspensions with high drug loading, so that injection volumes can be minimized. Such innovative nanosuspensions are well tolerated in animals and humans after intramuscular injection and provide sustained drug co...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Current state and limitations of daily oral therapy for treatment
Purpose of review: We aim to review the strengths and weaknesses of current antiretroviral therapy (ART), and describe ongoing research to address limitations to current therapy. Recent findings: Current ART is highly effective and well tolerated. As a result of a decrease in medication side-effects and pill burden, and the known health effects of uncontrolled viremia, ART is now recommended at all CD4 cell counts in the USA. Novel medications are being developed to further decrease side-effects and offer alternative options for patients with multiclass resistance. New combination pills will further decrease pill burden. Summary: Current treatment for HIV is characterized by highly potent oral antiretroviral medications, which are well tolerated, resulting in outstanding rates of virologic...
The current status of the use of oral medication to prevent HIV transmission
Purpose of review: This review was designed to evaluate the progress in studies of the use of oral and topical antiretroviral (ARV) medication for primary HIV prevention. Recent findings: Nonhuman primate data have suggested that the administration of ARV medication before or after retroviral exposure can protect against the establishment of chronic infection. Over the past two decades, observational studies have demonstrated the safety of ARV agents for postexposure prophylaxis and more recent efficacy studies have demonstrated that tenofovir with or without emtricitabine can protect against HIV when used as preexposure prophylaxis (PrEP). Efficacy studies have been conducted in diverse populations, including men and transgender women who have sex with men, young African heterosexuals, an...
Extending access with long-acting antiretroviral therapy: the next advance in HIV-1 therapeutics and prevention
No abstract available (Source: Current Opinion in HIV and AIDS)
One year on: vale Joep Lange
No abstract available (Source: Current Opinion in HIV and AIDS)
Editorial introductions
No abstract available (Source: Current Opinion in HIV and AIDS)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
South Africa: Fireworks At Aids Conference
[GroundUp] Benny Malakoane, MEC for Health in the Free State, came under fire while sitting in the audience at the opening of the 7th South African AIDS Conference in Durban on Tuesday evening. Treatment Action Campaign (TAC) chairperson, Nkhensani Mavasa, delivering one of the opening speeches, called for him to be dismissed. (Source: AllAfrica News: HIV-Aids and STDs)
South Africa: The New Aids Denialism
[Daily Maverick] On 9 June 2015, TAC Chairperson NKHENSANI MAVASA delivered the opening session speech at the SA AIDS Conference 2015. Here, in full, is the text of the address. (Source: AllAfrica News: HIV-Aids and STDs)
Which yogurt is the healthiest? The answer may surprise you
Studies have shown that regular yogurt consumption aids gut health, can lower blood pressure, ease hay fever, boost the immune system, lift mood and speed weight loss. (Source: the Mail online | Health)
SNMMI: PET/CT aids non-Hodgkin's lymphoma patients
PET/CT has the potential to catch a relapse of non-Hodgkin's lymphoma in its (more) (Source: AuntMinnie.com Headlines)
Africa: Deaths From HIV, Aids Drop in Sub-Sahara Africa
[Leadership] The African Group at the UN General Assembly said on Tuesday that new infections and deaths from HIV and AIDS has continued to decline in sub-Saharan Africa. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Europe's most homophobic countries may be paving the way for a rise in HIV cases
(London School of Hygiene & Tropical Medicine) Europe's most homophobic countries may be paving the way for a rise in HIV cases among gay and bisexual men, according to new research published in the journal AIDS. (Source: EurekAlert! - Social and Behavioral Science)
HIV/AIDS epidemic in the State of Amazonas: characteristics and trends from 2001 to 2012
A scoping review was conducted to describe the epidemiological characteristics of the human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) epidemic in the State of Amazonas, Brazil, from 2001 to 2012, and temporary patterns were estimated from surveillance data. The results suggest that in its third decade, the Amazon HIV/AIDS epidemic is far from being stabilized and displays rising AIDS incidence and mortality rates and late diagnoses. The data suggest that AIDS cases are hitting mostly young adults and have recently shifted toward men, both homosexual and heterosexual. AIDS cases among the indigenous people have remained stable and low. However, the epidemic has disseminated to the interior of the state, which adds difficulties to its control, given the geographica...
Epidemiology of infectious meningitis in the State of Amazonas, Brazil
CONCLUSIONS: Changes in the epidemiological profile for the different etiology-defined cases are the result of continuous epidemiological surveillance and laboratory capacity improvements and control measures, such as Haemophilus influenzae vaccination. (Source: Revista da Sociedade Brasileira de Medicina Tropical)
IJERPH, Vol. 12, Pages 6591-6607: Why Don?t Smokers Want Help to Quit? A Qualitative Study of Smokers? Attitudes towards Assisted vs. Unassisted Quitting
This study explored the attitudes of smokers towards a range of quitting methods, and their considerations when judging their value. We conducted semi-structured interviews with 29 smokers and analysed data using thematic analysis. The results show that the perceived nature of an individual smoker?s addiction was central to judgments about the value of pharmacological cessation aids, as was personal experience with a method, and how well it was judged to align with an individual?s situation and personality. Unassisted quitting was often described as the best method. Negative views of pharmacological cessation aids were frequently expressed, particularly concerns about side effects from prescription medications. Smokers? views about the value of different methods were not independent:...
Autoimmune Epilepsy
Semin Neurol 2015; 35: 245-258DOI: 10.1055/s-0035-1552625Seizures are recognized as a common manifestation of autoimmune limbic encephalitis and multifocal paraneoplastic disorders, but accumulating evidence supports an autoimmune basis for seizures in the absence of syndromic manifestations of encephalitis. Autoimmune encephalitis and epilepsy have been linked to neural-specific autoantibodies targeting both intracellular and plasma membrane antigens. The detection of these antibodies can serve as a diagnostic marker directing physicians toward specific cancers and can assist in therapeutic decision-making, but are not necessary to establish the diagnosis. Response to an immunotherapy trial can support the diagnosis and help establish prognosis. Early recognition is important because expe...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Developing Effective Decision Support for the Application of ?Gentle? Remediation Options: The GREENLAND Project
This article introduces the decision support framework. ©2015 Wiley Periodicals, Inc. (Source: Remediation Journal)
Zambia: 2 in Court Over Fake HIV/Aids Cure
[Times of Zambia] TWO people have appeared in court for illegally manufacturing and selling a drug they claimed cures HIV/AIDS. (Source: AllAfrica News: Health and Medicine)
Kenya: Secrecy Fuels HIV Infections in Kisumu Teens
[The Star] For only Sh1,500, Maurine got infected with HIV but she did not know about it until much later when out of fun she decided to walk into a testing centre. (Source: AllAfrica News: HIV-Aids and STDs)
Veterans and HIV Screening Rates: Why Veterans Are Not Getting Tested, a Veterans Affairs Nursing Academic Partnership (VANAP) Study
The Veterans Health Administration (VHA) is the largest single provider of HIV care in the United States. As of 2008, almost 64,000 veterans had received HIV care through this system. Despite new guidelines from the Centers for Disease Control and Prevention (CDC; 2006) for HIV screenings, and VHA Directives eliminating the need for written consent, voluntary screening for HIV among veterans remains low. According to a blinded study of HIV testing at six large VHA facilities, the prevalence of undiagnosed HIV infection in outpatients ranged from 0.1% to 2.8% (Owens et al., 2007). (Source: Journal of the Association of Nurses in AIDS Care)
ANAC Strategic Plan (2015-2017)
Envisioned Future: The Association of Nurses in AIDS Care (ANAC) is a globally recognized professional nursing association that is the preeminent source of nursing expertise in all dimensions of HIV prevention, care and treatment, research, and policy. (Source: Journal of the Association of Nurses in AIDS Care)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
ANAC's Strategic Plan: Charting a Course to a Dynamic and Vibrant Future
More than a year ago, the Association of Nurses in AIDS Care (ANAC) launched a new logo, which embodied the diversity, the vibrancy, and the sense of community shared by ANAC members. The logo is reflective of ANAC's core values: Knowledge, Diversity, Collaboration, Support, and Advocacy. The launch of this new logo marked an important step toward a revitalized ANAC and a commitment to enhancing our value, visibility, and relevance for today, tomorrow, and well into the future. (Source: Journal of the Association of Nurses in AIDS Care)
Is the Patient Protection and Affordable Care Act Safe?
I am a firm believer in the people.If given the truth, they can be depended upon to meet any national crisis.The great point is to bring them the real facts.Abraham Lincoln (1809-1865) (Source: Journal of the Association of Nurses in AIDS Care)
Cover 1
(Source: Journal of the Association of Nurses in AIDS Care)
Editorial Board
(Source: Journal of the Association of Nurses in AIDS Care)
Masthead
(Source: Journal of the Association of Nurses in AIDS Care)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Table of Contents
(Source: Journal of the Association of Nurses in AIDS Care)
Board of Directors
(Source: Journal of the Association of Nurses in AIDS Care)
Botswana: NACA Targets Adolescents
[Botswana Daily News] Gaborone -New HIV infections among adolescents are a cause for concern, National AIDS Coordinating Agency (NACA) coordinator, Ms Grace Muzila has said. (Source: AllAfrica News: Health and Medicine)
Attitudes Towards Power in Relationships and Sexual Concurrency Within Heterosexual Youth Partnerships in Baltimore, MD
We examined this association among Baltimore youth (N = 352), aged 15?24. Data were collected from February, 2011 to May, 2013. We examined whether index concurrency in male-reported partnerships (N = 221) and sex partner?s concurrency in female-reported partnerships (N = 241) were associated with youth?s attitudes towards relationship power. Males with more equitable beliefs about power were less likely to report index concurrency. Females with more equitable beliefs were more likely to report sex partner?s concurrency. The relationship was significant in main and casual partnerships among females and main partnerships among males. The strongest associations were detected among middle-socioeconomic status (SES) males and low-SES and African American females. Implementing in...
Factors Associated with Non-disclosure of HIV Status in a Cohort of Childbearing HIV-Positive Women in Ukraine
Abstract Ukraine has one of the largest populations of persons living with HIV in Europe. Data on 2019 HIV-positive married or cohabiting women enrolled in a postnatal cohort from 2007 to 2012 were analysed to investigate prevalence and factors associated with self-reported non-disclosure of HIV status. Median age at enrolment was 27.5 years, with two-thirds diagnosed during their most recent pregnancy. Almost all had received antenatal antiretroviral therapy and 24 % were taking it currently. One-tenth (n = 198) had not disclosed their HIV status to their partner and 1 in 20 (n = 93) had disclosed to no-one. Factors associated with non-disclosure were: unmarried status (AOR 2.99 (95 % CI 1.51?5.92), younger age at leaving full-time education (AOR 0.41 (95 % CI 0.19?0....<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Attitudes and Acceptability on HIV Self-testing Among Key Populations: A Literature Review
Abstract HIV self-testing (HIVST) is a potential strategy to overcome disparities in access to and uptake of HIV testing, particularly among key populations (KP). A literature review was conducted on the acceptability, values and preferences among KP. Data was analyzed by country income World Bank classification, type of specimen collection, level of support offered and other qualitative aspects. Most studies identified were from high-income countries and among men who have sex with men (MSM) who found HIVST to be acceptable. In general, MSM were interested in HIVST because of its convenient and private nature. However, they had concerns about the lack of counseling, possible user error and accuracy. Data on the values and preferences of other KP groups regarding HIVST is limited....
Access to post-exposure prophylaxis following sexual exposure for men who have sex with men in an Irish healthcare setting
This study identifies a need to educate healthcare workers in emergency departments on appropriate use of post-exposure prophylaxis following sexual exposure for men who have sex with men. Health care workers must appreciate the importance of post-exposure prophylaxis presentations as opportunities for intervention and HIV screening. (Source: International Journal of STD and AIDS)
Differences in correlates of condom use between young adults and adults attending sexually transmitted infection clinics
This study sought to examine how condom use and its correlates differed between high-risk young adults and adults. Sexually transmitted infection (STI) clinic patients (n = 763) reported STI history, contraception, negative condom attitudes, fear of partner reaction to condom use and risky behaviours. Past 3-month condom use was examined as unprotected vaginal sex (UVS) acts, proportional condom use and consistent condom use. Regression models tested associations of age group and potential correlates with each condom use outcome. Interaction models tested whether associations differed by age group. Proportional condom use was greater in young adults than adults (mean 0.55 vs. 0.47); UVS and consistent condom use were similar between age groups. Young adults with a recent STI reported less ...
Factors associated with high rates of antiretroviral medication adherence among youth living with perinatal HIV in Thailand
Antiretroviral medication adherence behaviour among Thai youth with perinatal HIV in Thailand has received growing attention. However, few studies have examined individual predictors of antiretroviral adherence using multiple self-reports. A convenience sample of 89 Thai youth (interquartile range 14&ndash;16 years) with perinatal HIV at three paediatric programmes in Chiang Mai completed a structured questionnaire and reported their antiretroviral adherence in the past one, seven and 30 days using count-based recall and a visual analog scale. Mean self-reported adherence rates ranged from 83.5% (past 30 days) to 99.8% (yesterday) of the time. One-inflated beta regression models were used to examine the associations between antiretroviral adherence outcomes, treatment self-efficacy, depres...
Predictive factors of unprotected sex for female sex workers: first study in French Guiana, the French territory with the highest HIV prevalence
The objective of this study was to describe consistent condom use among female sex workers with their clients and their intimate partners and to identify determinants of non-use of condoms. An HIV/AIDS Knowledge, Attitudes, Behaviours and Practices survey was conducted in 2009&ndash;2010 among sex workers in French Guiana. A total of 477 sex workers were interviewed. Female sex workers were more likely to use condoms with their clients (97%) than with their intimate partners (45%). The factors associated with non-consistent condom use with the intimate partner were having had an abortion, feeling at risk for HIV, not evaluating one&rsquo;s own risk for HIV, living as a couple, being Dominican, and not feeling comfortable asking intimate partners to use condoms. Although a high proportion o...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Factors associated with failure to return for HIV test results in a free and anonymous screening centre
This study aimed to assess factors associated with failure to return for HIV test results. Patients visiting the Fernand-Widal CDAG (Paris) for an HIV test in January&ndash;February 2011 were eligible to take part in the study. Data were collected with an anonymous self-administered questionnaire. Factors associated with failure to return were assessed using logistic regression models. Of the 710 participants (participation rate 88%), 46 patients failed to return. Not specifying birthplace and not living in the region of Paris were associated with failure to return. Those who perceived no risk of HIV infection and those who felt they were more at risk than other people were both statistically associated with failure to return. Self-perceived risk seemed to be of chief concern for failure t...
The changing relationship between bacterial STIs and HIV prevalence in South Africa - an ecological study
Prevalence estimates of various bacterial sexually transmitted infections in South Africa have declined considerably since the mid-1990s. Syphilis among pregnant women, for example, declined from 10.8% in 1998 to 2.8% in 2001. We used Pearson&rsquo;s correlation coefficients to estimate the association between the prevalence of syphilis/male urethral discharge/male genital ulcers and the peak HIV prevalence at a district and provincial level in the early and late phases of the HIV epidemic in South Africa. Prevalence estimates of syphilis, male urethral discharge and male genital ulcers during the period preceding the peak HIV prevalence were all positively correlated with the peak HIV prevalence at a provincial level (Pearson&rsquo;s correlation coefficient [r] = 0.83, p = 0.006; r = 0.66...
Partner notification among men who have sex with men and heterosexuals with STI/HIV: different outcomes and challenges
Partner notification effectiveness among index clients diagnosed with HIV, syphilis and/or gonorrhoea at sexually transmitted infection (STI) clinics was evaluated between 2010 and 2012. We explored percentages of identifiable, notified and tested partners by sexual preference and gender. Partner notification trends were studied using the national STI database. Men who have sex with men (n = 304), heterosexual men (n = 33) and women (n = 35) reported, respectively, 6.7, 3.8 and 2.3 partners per index. Percentages of identifiable partners differed between groups (men who have sex with men: 46%, heterosexual men: 63%, women: 87%, p &lt; 0.001). The percentage of notified partners (of those identifiable) was lowest for heterosexual men (76%; men who have sex with men: 92%; women: 83%; p &lt; ...
The effect of valacyclovir on HIV and HSV-2 in HIV-infected persons on antiretroviral therapy with previously unrecognised HSV-2
In the absence of antiretroviral therapy, valacyclovir may reduce HIV viral load and increase CD4+ T-lymphocyte count. We sought to evaluate the impact of valacyclovir on HIV and HSV-2 in co-infected patients receiving antiretroviral therapy with previously unrecognised HSV-2 infection. A prospective, randomised-controlled, 24-week trial of valacyclovir 1000 mg was performed. Mean CD4+ T-lymphocyte count at 24 weeks compared to baseline CD4+ T-lymphocyte count was the primary outcome. HIV viral load suppression, HSV-2 outbreaks and asymptomatic HSV-2 shedding were secondary outcomes. Participants were randomised to valacyclovir (N = 66) or placebo (N = 35). Study completion was 64%. There was no change in 24 weeks compared to baseline CD4+ T-lymphocyte count in either group (valacyclovir p...
Magnetic resonance imaging evaluation of lipodystrophy in HIV-positive patients receiving highly active antiretroviral therapy
We evaluated retrospectively an automated method for the separate detection of subcutaneous and visceral fat in the abdominal region by magnetic resonance studies in HIV-positive patients on highly active antiretroviral therapy. The patients were divided into four different groups: lipoatrophy, lipohypertrophy, mixed and the control group. The use of software for the automated detection of abdominal compartment visceral adipose tissue (VAT), total adipose tissue (TAT) and subcutaneous adipose tissue (SAT) was compared to manual evaluation methods (fuzzy C-mean). The results of ROC analysis showed that the parameters, particularly the VAT, are better than the VAT/TAT and at identifying patients with the symptoms of abdominal fat accumulation. A sensitivity of 80.3% and a specificity of 79.5...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Does dropping day 5 PEP follow-up affect outcomes? An audit of HIV post-exposure prophylaxis at a central London sexual health clinic
UK post-exposure prophylaxis (PEP) guidelines were updated by the British Association for Sexual Health and HIV (BASHH) in 2011. In 2013, we changed policy to omit day 5 PEP follow-up at 56 Dean Street as it was felt clinically unnecessary. This audit compares our performance against BASHH standards for PEP attenders during June 2012 and June 2013. We identified 162 PEP prescriptions; PEP assessment and appropriate sexually transmitted infection testing was done well. PEP completion rates and post-PEP HIV testing were lower than BASHH standards. Following omission of day 5 review, documentation that results have been checked was poor; however, attendance at follow-up was not adversely affected. (Source: International Journal of STD and AIDS)
The utility of genotypic tropism testing in clinical practice
A review of a large number of HIV-1 tropism test requests (n = 1148) performed at a London tertiary referral centre was carried out. The aim was to establish whether these were being performed in line with recommendations from published guidelines and whether this represented the most cost-effective use of these tests in informing prescribing decisions of the CCR5 antagonist drug, maraviroc. The cost of these assays within the UK was covered by commercial funding until April 2013 which has subsequently been withdrawn. Furthermore, all healthcare settings are under increasing cost constraints and hence establishing the real utility and appropriate use of these tests is of vital importance. (Source: International Journal of STD and AIDS)
Gonorrhoea of the sigmoid neovagina in a male-to-female transgender
A 33-year-old male-to-female transgender consulted our outpatient clinic with perneovaginal bleeding during and following coitus. Four years before, she underwent a total laparoscopic sigmoid neovaginoplasty. Physical, histological and endoscopic examination revealed neither focus of active bleeding nor signs of active inflammation. A polymerase chain reaction test performed on a neovaginal swab showed gonococcal infection. Treatment consisted of 500 mg intramuscular ceftriaxone. Three weeks later, our patient reported resolution of symptoms, consistent with eradication of the infection demonstrated by a follow-up neovaginal swab polymerase chain reaction. To our knowledge, this is the first case report of gonococcal infection of the sigmoid neovagina. (Source: International Journal of STD...
A case of female urogenital schistosomiasis presenting as viral warts
Schistosomiasis is uncommon in the UK but is found in migrant populations and in those who travel to areas of endemic schistosomiasis. Apparent clinical symptoms may occur long after the patient has left an endemic area. Female urogenital schistosomiasis (arising from infection by Schistosoma haematobium, endemic in Africa and the Middle East) may show a variety of lesions in the female genital tract, some of which may be misdiagnosed as viral warts. One such case is presented here. A young woman presented with lesions on the labia minora suspected to be viral warts which had not responded to treatment with cryotherapy. Biopsy of the lesions and spun urine microscopy revealed S. haematobium eggs. The lesions resolved following treatment with praziquantel. Clinicians should also be aware of...
Kikuchi-Fujimoto Disease: part of the differential diagnosis of cervical lymphadenopathy in an HIV-positive patient
A 38-year-old HIV-positive Nigerian woman presented with a three-week history of cervical lymphadenopathy, night sweats, weight loss and fever. Provisional diagnoses of tuberculosis and lymphoma were considered; however, a histological diagnosis of Kikuchi-Fujimoto Disease was reached. This rare benign disease has presenting features that mimic more serious conditions commonly occurring in HIV-positive patients. This case report emphasises the importance of Kikuchi-Fujimoto Disease in the differential diagnosis of cervical lymphadenopathy in HIV-positive patients. (Source: International Journal of STD and AIDS)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
A case of relapsed visceral Kaposi's sarcoma with bilateral chylothoraces successfully treated with paclitaxel
We report a case with bilateral chylothoraces secondary to relapsed visceral Kaposi&rsquo;s sarcoma who was successfully treated with paclitaxel chemotherapy. (Source: International Journal of STD and AIDS)
Self-Assessment of Hearing and Purchase of Hearing Aids by Middle-Aged and Elderly Adults
Conclusion?There is evidence that low self-assessment scores lead to the purchase of hearing aids, although no significant association was observed in the sample.[...]Thieme Publicações Ltda Rio de Janeiro, BrazilArticle in Thieme eJournals:Table of contents  |  Abstract  |  open access Full text (Source: International Archives of Otorhinolaryngology)
The Americans with Disabilities Act and HIV/AIDS Discrimination
This Viewpoint discusses the role the Americans with Disabilities Act could play in ensuring that persons with HIV/AIDS can access health care without stigma and discrimination. (Source: JAMA - Journal of the American Medical Association)
Disability Grant: a precarious lifeline for HIV/AIDS patients in South Africa
Background: In South Africa, HIV/AIDS remains a major public health problem. In a context of chronic unemployment and deepening poverty, social assistance through a Disability Grant (DG) is extended to adults with HIV/AIDS who are unable to work because of a mental or physical disability. Using a mixed methods approach, we consider 1) inequalities in access to the DG for patients on ART and 2) implications of DG access for on-going access to healthcare. Methods: Data were collected in exit interviews with 1200 ART patients in two rural and two urban health sub-districts in four different South African provinces. Additionally, 17 and 18 in-depth interviews were completed with patients on ART treatment and ART providers, respectively, in three of the four sites included in the quantitative p...
De-novo design, synthesis and evaluation of novel 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives as HIV-1 reverse transcriptase inhibitors
Conclusion: The results obtained from this investigation revealed that, the synthesized compounds (5a-o) and (8a-o) showed moderate to promising HIV-1 RT inhibition activity. The overall SAR studies can help in identification of further lead as well as in designing of newer potential inhibitor of HIV-1 RT.Graphical Abstract8hBest docked pose of compound 8h inside the non-nucleoside inhibitory binding pocket of 3MEE enzyme. (Source: Chemistry Central Journal)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
WormGUIDES: an interactive single cell developmental atlas and tool for collaborative multidimensional data exploration
Conclusion: WormGUIDES provides an important tool for examining developmental processes and developing mechanistic hypotheses about their control. Critically, it provides the typical end user with an intuitive interface for developing and sharing custom visualizations of developmental processes. Equally important, because users can select cells based on their position and search for information about them, the app also serves as a spatially organized index into the large body of knowledge available to the C. elegans community online. Moreover, the app can be used to create and publish the result of exploration: interactive content that brings other researchers and students directly to the spatio-temporal point of insight. Ultimately the app will incorporate a detailed time lapse record of ...
Infection of ectocervical tissue and universal targeting of T-cells mediated by primary non-macrophage-tropic and highly macrophage-tropic HIV-1 R5 envelopes
Conclusions: Our data support ectocervical tissue as a favorable environment for non-mac-tropic HIV-1 R5 variants and emphasize the role of T-cells as initial targets for infection even for highly mac-tropic variants. (Source: Retrovirology)
Cognitive Behavior Therapy Can Help Treat Insomnia
http://media.boston.cbslocal.com/CBSBOS_0806201517271800000AA.mp4 BOSTON (CBS) &#8211; One in ten Americans suffers from chronic insomnia and tens of millions of prescriptions for sleep aids are written every year, but there may be a drug-free solution for patients who have trouble sleeping. A study finds that cognitive behavior therapy or CBT can help treat chronic insomnia in place of drugs. CBT involves teaching patient habits and relaxation techniques that reduce sleep anxiety and promote better sleep. &#8220;It helps improve their difficulty falling asleep,? says Michelle Drerup, PsyD of the Cleveland Clinic. ?It helps them to have fewer awakenings in the middle of the night, and helps them improve their sleep efficiency and increase total sleep time.&#8221; In fact, Aus...
Sexually Transmitted Diseases Treatment Guidelines, MMWR 2015
The information in this report updates the Sexually Transmitted Diseases Treatment Guidelines, 2010. (Source: CDC HIV/AIDS Prevention)
Quadruple Anti-HCV Regimen Highly Effective in HCV/HIV Coinfected IndividualsQuadruple Anti-HCV Regimen Highly Effective in HCV/HIV Coinfected Individuals
A four-drug anti-HCV regimen provides sustained virological responses (SVR) in most individuals coinfected with HCV and HIV, researchers from France report. Reuters Health Information (Source: Medscape Gastroenterology Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Malawi: Empower Women to Lower HIV/Aids Rates - U.S Government
[Malawi News Agency] Nsanje -The United States (US) government says women who are skilled and economically empowered are more likely to have lower rates of HIV/Aids, sexually transmitted infections and enjoy greater equality of life in society. (Source: AllAfrica News: Health and Medicine)
Liberia: UNFPA, GOL Launch Condom Promotion Campaign
[NEWS] The United Nations Population Fund (UNFPA) in collaboration with the Government of Liberia and other stakeholders has launched the National Condom Promotion Campaign targeting reduction in unwanted pregnancies and sexually transmitted diseases. (Source: AllAfrica News: HIV-Aids and STDs)
New blood test for viral infections shows promise
Conclusion This research has developed a test that is able to identify past viral infections using a small sample of blood, giving an insight into a person's history of viral infections. The test could theoretically be expanded to cover other types of organisms that cause human disease, such as bacteria. No test is perfect, however, and there were some cases where a known infection was not identified (false negative) and where an infection was picked up that was not thought to have really occurred (false positive). The test detects antibodies generated in response to viruses as the result of vaccination. Antibody response also reduces over time, so the test may not be able to identify all previous infections. The researchers thought this was why they detected less exposure to some common ...
Nigeria: NACA Targets 15,000 for HIV Counselling, Testing in Lagos
[Vanguard] The National Agency for the Control of AIDS, NACA, has said that it is targeting about 15,000 people for Human Immune deficiency Virus, HIV, testing and counselling in the ongoing free medical outreach programme in Lagos. (Source: AllAfrica News: HIV-Aids and STDs)
Screening Tool for HIV-Associated Neurocognitive DisordersScreening Tool for HIV-Associated Neurocognitive Disorders
This diagnostic tool is more accurate than previous screening tools for HIV-associated neurocognitive disorders. AIDS (Source: Medscape Today Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
South Africa: Deputy President Cyril Ramaphosa - SA National Aids Council Lekgotla
[SA Govt] Opening remarks by Deputy President Cyril Ramaphosa at the SA National Aids Council Lekgotla Emperor's Palace, Ekurhuleni (Source: AllAfrica News: HIV-Aids and STDs)
South Africa: Deputy President Cyril Ramaphosa Addresses Seventh SA Aids Conference
[SA Govt] Deputy President Cyril Ramaphosa, in his capacity as the Chairperson of the SANAC, will deliver a keynote address during the opening session of the seventh SA AIDS Conference on Tuesday 9 June 2015 at the Inkosi Albert Luthuli International Convention Centre in Durban. (Source: AllAfrica News: HIV-Aids and STDs)
Rwanda: Police Launch Free HIV Testing
[New Times] Police officers operating in the Western Province, together with other counterparts in crime prevention including personnel under District Administrative Security Support Organ (DASSO), received free HIV testing courtesy of Rwanda National Police (RNP) in partnership with the Ministry of Health. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: Corps Members Educate Pupils On HIV/Aids in Ogun
[Independent (Lagos)] Secondary school students in Abeokuta North Local Government Area of Ogun State, were on Thursday sensitised and educated on the menace of HIV/AIDS by members of the National Youth Service Corps (NYSC). (Source: AllAfrica News: HIV-Aids and STDs)
Terry on Ryan White
The Ryan White CARE (Comprehensive AIDS Resources Emergency) Act has facilitated tremendous advancements in the treatment of HIV and AIDS, particularly with regard to connecting people living with HIV to care and keeping those individuals in care. Specifically, the development of Early Intervention Specialist (EIS) services and Medical Case Management (MCM) services have made a significant impact on low-income people living with HIV. Appointments, transportation, childcare, navigating insurance fees and finding the appropriate medical provider can be difficult or even impossible for people living with HIV, whether they are newly diagnosed or have been living with HIV for some time. In communities where HIV rates are the highest, EIS and MCM provide support and guidance for those needing to...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Marvell Terry II
HIV/AIDS FellowMarvell Terry II has been living with HIV since 2007 ? and advocating against stigma and for prevention and treatment for the last 10 years. In January, he joined the Human Rights Campaign Foundation as the HIV and AIDS Project Fellow, where he works to help those within the LGBT community who are most affected by HIV and AIDS. Conversations ContributorsCompany:&nbsp;Human Rights CampaignRelated Conversation:&nbsp;What advancements in the treatment of HIV/AIDS should be celebrated during the anniversary of the Ryan White Care Act? (Source: PHRMA)
Africa: Five Children Under Five Die Every Minute
[The Herald] In 2013, an estimated 6,3 million children under five died, 2,9 million of them in the WHO African region. (Source: AllAfrica News: HIV-Aids and STDs)
Zimbabwe: Hubby Tries to Kill HIV Positive Wife, Court Told
[The Herald] An HIV-positive woman approached the Harare Civil Court seeking a protection order against her husband who attempted to kill her twice through food poisoning. (Source: AllAfrica News: HIV-Aids and STDs)
Zimbabwe: Prostitutes Savour Concourt Ruling
[The Herald] "The judgment is very welcome because it protects the rights of women and comes as an example of constitutionalism. It has vindicated the constitution especially the freedom of movement which proves that our Constitution is just." (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: HIV/Aids Infection Rate Is Decreasing - NACA
[Leadership] The National Bureau of Statistics (NBS) in a recent report averred that most deaths in the country were disease-related. From the diseases identified in the report, HIV/AIDS accounted for much of the deaths. But the National Agency for the Control of AIDS (NACA) insists Nigeria is winning the war against HIV/AIDS. WINIFRED OGBEBO reports (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Overdose of dolutegravir in combination with tenofovir disaproxil fumarate/emtricitabine in suicide attempt in a 21-year old patient.
Authors: Lee M, Eyer F, Felgenhauer N, Klinker HH, Spinner CD Abstract A 21 year old MSM patient with newly diagnosed HIV infection was hospitalized in our department after ingestion of an overdose of his antiretroviral therapy (ART) comprising dolutegravir (DTG - Tivicay®) and tenofovir disaproxil fumarate/emtricitabine (Truvada®) in suicidal intention. On admission, the patient did not show any clinical signs of intoxication and laboratory findings were unremarkable. After 6 hours of intensive care monitoring, the patient was referred to a psychiatric clinic. 5 days after the day of intoxication, serum creatinine levels increased to high normal values (1.2 mg/dl). However, levels never exceeded the upper threshold. 8 and 12 weeks later, serum creatinine normalized to level...
Transdiagnostic Psychopathology Mediates the Relationship Between Childhood Sexual Abuse and HIV/AIDS and other Sexually Transmitted Infections in Adulthood
Exposure to childhood sexual abuse (CSA) is associated with elevated rates of mental disorders, sexual risk behavior, and sexually transmitted infections (STIs) in adulthood. Mental disorders themselves are associated with an increased risk for HIV/AIDs and STIs as well, and thus may mediate the association between CSA and HIV/AIDS and other STIs. The links among CSA, disorders, and STIs are unclear, however. The current study tested the hypothesis that the association of CSA with STIs is mediated by adult transdiagnostic psychopathology. (Source: Comprehensive Psychiatry)
The serologic decoy receptor 3 (DcR3) levels are associated with slower disease progression in HIV-1/AIDS patients
Conclusion HIV-1-infected cells may gain a survival advantage by activating DcR3, which prevents infected cell detection by the host immune system. These data indicate that the sDcR3 level is a biomarker for AIDS disease progression. (Source: Journal of the Formosan Medical Association)
Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990?2013: a systematic analysis for the Global Burden of Disease Study 2013
Publication date: Available online 7 June 2015 Source:The Lancet Background Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013. Methods Estimates were calculated for disease and injury incidence, prevalence, and YLDs using GBD 2010 methods with some important refinements. Results for incidence of acute disorders and prevalence of chronic disorders are new additions to the analysis. Key improvements include expansion to the cause and sequelae list, updated systematic reviews...
PEPFAR Funding Associated With An Increase In Employment Among Males in Ten Sub-Saharan African Countries [Global]
The President&rsquo;s Emergency Plan for AIDS Relief (PEPFAR) has provided billions of US tax dollars to expand HIV treatment, care, and prevention programs in sub-Saharan Africa. This investment has generated significant health gains, but much less is known about PEPFAR&rsquo;s population-level economic effects. We used a difference-in-differences approach to compare employment trends between ten countries that received a large amount of PEPFAR funding (focus countries) and eleven countries that received little or no funding (control countries). We found that PEPFAR was associated with a 13&nbsp;percent differential increase in employment among males in focus countries, compared to control countries. However, we observed no change in employment among females. In addition, we found that in...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Book Marks [BookMarks]
(Source: Health Affairs)
South Africa: Results of Survey On HIV Stigma Expected
[SAnews.gov.za] The results of the South African Stigma Survey are expected to be released at the 7th South Africa AIDS Conference which kicks off in Durban on Tuesday. (Source: AllAfrica News: HIV-Aids and STDs)
East Africa: Free Movement Fuels HIV/Aids
[Arusha Times] Free movement of people in East Africa, desired by policy makers to speed up regional integration, has fueled infectious diseases, particularly HIV/Aids and tuberculosis, it was observed in Arusha last week. (Source: AllAfrica News: HIV-Aids and STDs)
Perception of sexuality and fertility in women living with HIV: a questionnaire study from two Nordic countries.
CONCLUSIONS: In conclusion, the majority of WLWH in industrialized settings in Denmark and Finland have few HIV-related symptoms, are sexually active and have a strong desire for children. PMID: 26037151 [PubMed - in process] (Source: Journal of the International AIDS Society)
Internalized HIV and Drug Stigmas: Interacting Forces Threatening Health Status and Health Service Utilization Among People with HIV Who Inject Drugs in St. Petersburg, Russia
Abstract Marked overlap between the HIV and injection drug use epidemics in St. Petersburg, Russia, puts many people in need of health services at risk for stigmatization based on both characteristics simultaneously. The current study examined the independent and interactive effects of internalized HIV and drug stigmas on health status and health service utilization among 383 people with HIV who inject drugs in St. Petersburg. Participants self-reported internalized HIV stigma, internalized drug stigma, health status (subjective rating and symptom count), health service utilization (HIV care and drug treatment), sociodemographic characteristics, and health/behavioral history. For both forms of internalized stigma, greater stigma was correlated with poorer health and lower likeliho...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Ears tuned
Publication date: 6 June 2015 Source:New Scientist, Volume 226, Issue 3024 Hearing aids pick up airborne acoustic signals, and can be switched to receive signals from? (Source: New Scientist)
Phenotypical and functional profiles of natural killer cells exhibiting matrix metalloproteinase?mediated CD16 cleavage after anti?HIV antibody?dependent activation
Summary Natural killer (NK) cell?mediated antibody?dependent cellular cytotoxicity (ADCC) has been linked to protection from HIV infection and slower progression towards AIDS. However, antibody?dependent activation of NK cells results in phenotypical alterations similar to those observed on NK cells from individuals with progressive HIV infection. Activation of NK cells induces matrix metalloproteinase (MMP)?mediated cleavage of cell surface CD16. In the present study we assessed the phenotype and functional profile of NK cells exhibiting post?activation MMP?mediated CD16 cleavage. We found that NK cells achieving the highest levels of activation during stimulation exhibit the most profound decreases in CD16 expression. Further, we observed that educated KIR3DL1+ NK cells from ...
Restriction Factors in HIV-1 Disease Progression.
Authors: Merindol N, Berthoux L Abstract About 35 million people worldwide were living with HIV-1 at the end of 2013 and over 25 million have already died of AIDS. AIDS patients show high variability in the speed of disease progression in the absence of treatment. While certain immunological traits have been shown to correlate with accelerated or slowed progression in some subjects, including slow progressors, factors controlling HIV-1 replication and disease kinetics remain largely enigmatic. The importance of T lymphocytes and of protective HLA-alleles is undeniable, but not sufficient to explain every attenuated phenotype. A thorough understanding of HIV-1 infection control in these patient subsets may help the development of novel strategies for treatment and prevention. Restri...
Predictors for uptake of intermittent preventive treatment of malaria in pregnancy (IPTp) in Tanzania
Conclusion: Applying these results could contribute to positive social change by helping providers, clinics, and organizations seeking to increase IPTp uptake among ANC attendees and providing health education programs to women, especially those residing in rural areas. This study could also help achieve United Nations Millennium Development Goals (MDG) 6 (combat HIV/AIDS, Malaria and Other Diseases). (Source: BMC Public Health)
Antioxidant drugs to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis: What does evidence suggest?
CONCLUSION: Antioxidant supplementation shows no beneficial effect on the incidence of PEP. There is a lack of robust trials to support the use of antioxidants for prevention. PMID: 26074713 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Whole genome methylation array reveals the down-regulation of IGFBP6 and SATB2 by HIV-1.
This study also provides a resource for the identification of HIV-induced methylation and contributes to better understanding of the development of HIV/AIDS. PMID: 26039376 [PubMed - in process] (Source: Genomics Proteomics ...)
Zimbabwe: Funding Withdrawal Threat to Zimbabwe
[Financial Gazette] "As Africans we therefore need sound political commitments, enabling policy and legal provisions as well as domestic funding mechanisms for tackling HIV and Aids". (Source: AllAfrica News: Health and Medicine)
Dementia, decision aids and general practice.
This article offers an introduction to the use of decision aids by GPs when caring for patients with dementia (or their carers). In addition, obstacles that can arise during the development of dementia-related decision aids are explored. DISCUSSION: A person-centred approach to people with dementia is a worthy goal. Decision aids are evidence-based tools that help patients (and carers) participate in choosing among healthcare options. Several existing high-quality, dementia-related decision aids are of relevance to the primary care setting. However, there is a need for additional research to develop decision aids which address a broader range of issues pertinent to dementia. PMID: 26042403 [PubMed - in process] (Source: Australian Family Physician)
HLA-B* 35: 05 is a protective allele with a unique structure among HIV-1 CRF01_AE-infected Thais, in whom the B*57 frequency is low: Erratum
No abstract available (Source: AIDS)
HIV-1 group O resistance pathway with raltegravir is similar to HIV-1 group M
No abstract available (Source: AIDS)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Dolutegravir: successful experience in a challenging patient
No abstract available (Source: AIDS)
Soluble CD14 is a nonspecific marker of monocyte activation
Soluble CD14 is associated with morbidity and mortality in HIV disease. It is a co-receptor for lipopolysaccharide (LPS) that is released from monocytes upon activation. We demonstrate here, that inflammatory cytokines can induce the release of sCD14 in peripheral blood mononuclear cell cultures from healthy donors, and that TLR ligands other than LPS can cause a decrease in the monocyte cell surface expression of CD14. Thus, sCD14 is a marker of monocyte activation, not restricted to activation by LPS. (Source: AIDS)
Sustained virological failure in Cameroonese patient infected by HIV-1 group N evidenced by sequence-based genotyping assay
No abstract available (Source: AIDS)
Cost-effectiveness of first-line antiretroviral therapy for HIV-infected African children less than 3 years of age
Conclusions: On the basis of P1060 data, first-line lopinavir/ritonavir leads to longer life expectancy and is cost-saving or very cost-effective compared to first-line nevirapine. This supports WHO guidelines, but increasing access to pediatric ART is critical regardless of the regimen used. (Source: AIDS)
First-line antiretroviral therapy for HIV-infected children
No abstract available (Source: AIDS)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Psychiatric symptoms and antiretroviral nonadherence in US youth with perinatal HIV: a longitudinal study
Conclusion: In PHIV youth, comprehensive adherence interventions that address psychiatric conditions throughout the transition to adult care are needed. (Source: AIDS)
Hidden from health: structural stigma, sexual orientation concealment, and HIV across 38 countries in the European MSM Internet Survey
Conclusion: Country-level stigma may have historically limited HIV transmission opportunities among MSM, but by restricting MSM's public visibility, it also reduces MSM's ability to access HIV-preventive services, knowledge and precautionary behaviours. These findings suggest that MSM in European countries with high levels of stigma are vulnerable to HIV infection. Although they have less opportunity to identify and contact other MSM, this might change with emerging technologies. (Source: AIDS)
Epidemiology of Kaposi's sarcoma-associated herpesvirus in HIV-1-infected US persons in the era of combination antiretroviral therapy
Conclusions: HIV-1-infected individuals, in particular Caucasian men, remain at a significant risk for KSHV co-infection and Kaposi's sarcoma. Thus, optimal management of HIV-1 infection should continue to include vigilance for manifestations of KSHV co-infection, including Kaposi's sarcoma. Video abstract: https://vimeo.com/126172348 (Source: AIDS)
Liver-related death among HIV/hepatitis C virus-co-infected individuals: implications for the era of directly acting antivirals
Conclusion: Treatment with DAAs should be prioritized for those with at least F2 fibrosis. Early initiation of cART with the aim of avoiding low CD4+ cell counts should be considered essential to decrease the risk of LRD and the need for HCV treatment. (Source: AIDS)
Serum-free light chains in HIV-associated lymphoma: no correlation with histology or prognosis
In this study, we measured sFLCs at diagnosis of HALs, and correlated levels with histology and survival. Methods: The clinic database of the National Centre for HIV Malignancy was used to identify HAL patients, in the antiretroviral treatment era. Levels of sFLCs were measured using stored sera (cases from 1996 to 2008) and prospectively from 2008 to 2014. Serum immunoglobulins were available for 201 patients. We assessed correlations between sFLCs, serum immunoglobulins, and histological subtypes and overall survival. Results: Two hundred and sixty-four patients were identified and 70% had polyclonal sFLC, 8% monoclonal sFLC (90% kappa sFLC), and 22% normal sFLC levels. No significant difference in sFLCs was observed between the three major histological subtypes of HAL (Hodgkin's lymphom...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
The histone deacetylase inhibitor panobinostat lowers biomarkers of cardiovascular risk and inflammation in HIV patients
Conclusion: Collectively, these data indicate that panobinostat may have therapeutic potential to target excess inflammation in HIV patients with high cardiovascular risk. (Source: AIDS)
Association between gp120 envelope V1V2 and V4V5 variable loop profiles in a defined HIV-1 transmission cluster
Objective: Variations in the HIV-1 gp120 Env variable loop sequences correlate with virus phenotypes associated with transmission and/or disease progression. We aimed to identify whether signature sequences could be identified in the gp120 Env between acute infection and chronic infection viruses obtained from a group of individuals infected with closely related viruses. Methods: To analyse acute infection versus chronic infection viruses, we studied a transmission cluster of 11 individuals, in which six presented during acute infection and five during chronic infection. Multiple HIV-1 gp120 Env clones were sequenced from each patient with predicted amino acid sequences compared between the groups. Results: Cluster analysis of V1V5 Env sequences (n?=?215) identified that acute infectio...
Comparison of HBV-active HAART regimens in an HIV?HBV multinational cohort: outcomes through 144 weeks
Objectives: To explore factors associated with short and long-term hepatitis B virus (HBV) DNA suppression in a multinational cohort of HIV?HBV co-infected patients receiving HBV-active antiretrovirals. Methods: One hundred and fifteen HIV?HBV co-infected patients participating in one of the two global randomized clinical trials conducted by the Adult AIDS Clinical Trials Group of different antiretroviral regimens received either HBV monotherapy with either lamivudine or emtricitabine (N?=?56), or HBV dual therapy with tenofovir disoproxil fumarate (TDF) + lamivudine or emtricitabine (N?=?59). Associations of pretreatment characteristics with the primary (HBV DNA (Source: AIDS)
Lung cancer incidence and survival among HIV-infected and uninfected women and men
Conclusions: Our data suggest that pulmonary damage and inflammation associated with HIV infection may be causative for the increased risk of lung cancer. Encouraging and assisting younger HIV-infected smokers to quit and to sustain cessation of smoking is imperative to reduce the lung cancer burden in this population. (Source: AIDS)
A new model for post-integration latency in macroglial cells to study HIV-1 reservoirs of the brain
Conclusion: We conclude that latent HIV-1 in macroglial reservoirs can be activated by selected LRAs. Identification of small molecules that suppress HIV-1 reactivation supports functional cure strategies. We propose using the HNSC model to develop novel strategies to enforce provirus quiescence in the brain. (Source: AIDS)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Medroxyprogesterone acetate increases HIV-1 infection of unstimulated peripheral blood mononuclear cells in vitro
Objective: Several observational studies suggest that medroxyprogesterone acetate (MPA) injectable contraceptives may increase a woman's risk of sexual HIV-1 acquisition. In-vitro studies are conflicting, mainly due to differences in the type of progestin studied or activation status of the primary cells. We sought to determine whether MPA increases infection of unstimulated peripheral blood mononuclear cells (PBMCs). Methods: Freshly isolated PBMCs from normal blood donors were treated with physiologic MPA concentrations ranging from 0.003 to 5?ng/ml and infected with GFP-tagged R5-tropic or X4-tropic HIV-1 pseudoviruses by spinoculation. The infection was limited to a single cycle. Cells were stained with CD3, CD8 and CD14. Infection was quantified as the percentage of GFP+ cells by fl...
Men's heightened risk of AIDS-related death: the legacy of gendered HIV testing and treatment strategies
No abstract available (Source: AIDS)
A comparative phase 1 clinical trial to identify anti-infective mechanisms of vitamin D in people with HIV infection
Conclusion: Vitamin D supplementation modulates disease-relevant T-cell functions in HIV-infected patients, and may represent a useful adjunct to HAART therapy. (Source: AIDS)
Updated European paediatric guidelines focus on long-term health consequences of HIV-1 infection and treatment
No abstract available (Source: AIDS)
Fast disease progression in simian HIV-infected female macaque is accompanied by a robust local inflammatory innate immune and microbial response
Conclusion: These findings suggest that sex differences in local innate immune activation and compositional shifts in the gut microbiota could be the drivers of increased disease susceptibility in female macaques. Further studies with this novel nonhuman primate model of HIV infection could lead to innovative research on gender differences, which may have important therapeutic implications for controlling disease in infected men as well as women. (Source: AIDS)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
AIDS-Opportunistic Illness Mortality Lower but Still a RiskAIDS-Opportunistic Illness Mortality Lower but Still a Risk
Survival after the ?rst diagnosis of AIDS-opportunistic illness has markedly improved since 1981, but some AIDS-opportunistic illnesses still carry much higher mortality risk than others. Medscape Medical News (Source: Medscape Infectious Diseases Headlines)
Simian immunodeficiency virus impacts microRNA?16 mediated post?transcriptional regulation of mu opioid receptor in CEM x174 cells
In this study, we describe both the role played by miRNAs and the impact of SIVmac239 infection on post?transcriptional regulation of MOR gene OPRM1 gene in CEM x174 cells. Our results show that miR?16 is able to bind the target site in the range of 8699?8719 nt from the stop coden in MOR gene MOR?1 mRNA 3'?UTR and suppress the expression of MOR OPRM1 gene. Mutation of this target site reduces the effect of miR?16. Morphine (1 µM) inhibites the expression of miR?16, and this effect is reversed by the antagonist naloxone. Thus, morphine may up?regulate MOR receptor level by both stimulating MOR OPRM1 gene transcription and stabilizing its mRNA. SIVmac239 infection results in an apparent elevation of miR?16 and gradual reduction of MOR OPRM1 gene expression. The inverse co...
Gelatin Modified Porous CaP Ceramics for Bone Tissue Regeneration
Publication date: 2015 Source:Materials Today: Proceedings, Volume 2, Issue 1 Author(s): Bin Liu , Yijun Yao , Jing Su , Jingzhong Xiao We proposed a gelatin-aids surface modification strategy for improving the mechanical and biological properties of porous calcium phosphate (CaP) based ceramics. In vitro, co-culturing was carried out to evaluate attachment, proliferation and differentiation behaviors of the rabbit bone marrow-derived stromal cells (rBMSCs), indicating this strategy improves mechanical strength of CaP ceramics, maintains high porosity (&gt;80%) and pore interconnectivity, as well as significantly promotes rBMSCs response after culturing for several days. These imply the gelatin modification CaP ceramics possess improved cell biocompatibility and viability, and have a...
Evaluation of Microscopic Observation Drug Susceptibility (MODS) and the string test for rapid diagnosis of pulmonary tuberculosis in HIV/AIDS patients in Bolivia
Background: Tuberculosis (TB) is the most common opportunistic infection and the leading cause of death in HIV-positive people worldwide. Diagnosing TB is difficult, and is more challenging in resource-scarce settings where culture-based diagnostic methods rely on poorly sensitive smear microscopy by Ziehl-Neelsen stain (ZN). Methods: We performed a cross-sectional study examining the diagnostic utility of Microscopic Observation Drug Susceptibility liquid culture (MODS) versus traditional Ziehl-Neelsen staining (ZN) and Lowenstein Jensen culture (LJ) of pulmonary tuberculosis (TB) and multidrug-resistant tuberculosis (MDRTB) in HIV-infected patients in Bolivia. For sputum scarce individuals we assessed the value of the string test and induced sputum for TB diagnosis. The presence of Mycob...
The impact of a community-based HIV and sexual reproductive health program on sexual and healthcare-seeking behaviors of female entertainment workers in Cambodia
Conclusions: The overall findings of the study indicate that the SAHACOM is effective in reducing sexual risk behaviors and improving the access to SRH care services among FEWs in Cambodia. However, several unfavorable findings merit attention. (Source: BMC Infectious Diseases)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Perceived social support disparities among children affected by HIV/AIDS in Ghana: a cross-sectional survey
Conclusion: The findings indicate a need to develop interventions that can increase levels of social support for orphaned and vulnerable children within the context of HIV/AIDS in Ghana, particularly networks that include the family. (Source: BMC Public Health)
Opportunity Still Knocking for AIDS Illnesses (CME/CE)
(MedPage Today) -- Five-year survival after AIDS-defining illness has risen sharply but could be better still (Source: MedPage Today Public Health)
Prevalence, genotype distribution, and risk factors for hepatitis C infection among HIV-infected individuals in Slovenia: a 1986-2013 update.
DISCUSSION: Slovenia remains among the countries with the lowest prevalence of HCV infection in HIV-infected individuals. Because the burden of HIV among men who have sex with men in Slovenia is disproportionately high and increasing rapidly, the current favorable situation could change quickly and should be therefore monitored regularly. PMID: 24964945 [PubMed - in process] (Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica)
New test uses a single drop of blood to reveal entire history of viral infections
Cheap and rapid test allows doctors to access list of every virus that has infected or continues to infect a patient, and could transform disease detectionResearchers have developed a cheap and rapid test that reveals a person?s full history of viral infections from a single drop of blood.The test allows doctors to read out a list of the viruses that have infected, or continue to infect, patients even when they have not caused any obvious symptoms. Continue reading... (Source: Guardian Unlimited Science)
U.N. Challenges Asia-Pacific to Be World?s First Region to End AIDS Epidemic
HIV-positive women gather in Kathmandu, Nepal for a skills training. Credit: Bhuwan Sharma/IPSBy Thalif DeenUNITED NATIONS, Jun 5 2015 (IPS)The United Nations has expressed confidence that the Asia-Pacific region, with almost five million people living with HIV, is politically committed towards the elimination of the deadly disease AIDS.Michel Sidibé, executive director of UNAIDS, said the Asia-Pacific region is moving the world forward into new frontiers of development. "Our region has broken many barriers and saved countless lives, showing how developing countries can share responsibility, cooperate and take the lead in ending AIDS." -- Dr. Shamshad Akhtar?You have all the right tools in your hands, beginning with political commitment. I challenge you to be the first region to end the...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
A Comparison of Telephone Genetic Counseling and In-Person Genetic Counseling from the Genetic Counselor?s Perspective
Abstract Growing demand for and limited geographic access to genetic counseling services is increasing the need for alternative service delivery models (SDM) like telephone genetic counseling (TGC). Little research has been done on genetic counselors? perspectives of the practice of TGC. We created an anonymous online survey to assess whether telephone genetic counselors believed the tasks identified in the ABGC (American Board of Genetic Counseling) Practice Analysis were performed similarly or differently in TGC compared to in person genetic counseling (IPGC). If there were differences noted, we sought to determine the nature of the differences and if additional training might be needed to address them. Eighty eight genetic counselors with experience in TGC completed some or a...
Seroprevalence and risk factors of syphilis among HIV/AIDS patients in Istanbul, Turkey.
CONCLUSION: Since sexual contact is the most common route of transmission for both infections, syphilis seroprevalence was relatively high in our HIV/AIDS patients. Male and homosexual HIV/AIDS patients constituted a group at the highest risk for syphilis. PMID: 26036101 [PubMed - in process] (Source: Central European Journal of Public Health)
Gambia: LRR RAC Holds Quarterly Meeting
[Daily Observer] LRR -Members of the Regional Aids Committee in the Lower River Region recently held their quarterly meeting at the Office of the Governor in Mansakonko, Jarra West District. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: UNDP and UNAIDS Back Efforts By Least-Developed Countries to Secure Sustainable Access to Treatment
[UNDP] Geneva -The United Nations Development Programme (UNDP) and the Joint United Nations Programme on HIV/AIDS (UNAIDS) would like to call attention to the urgent and compelling case for the international community to take all measures possible to protect the health of people living in least-developed countries (LDCs). (Source: AllAfrica News: Health and Medicine)
Nigeria: Senate Approves Buhari's Request On Advisers
[Guardian] Abuja -The Senate yesterday granted President Mohammadu Buhari's request for the appointment of 15 Special Advisers. President Buhari had on Monday sought Senate's approval to enable him engage the services of 15 Special Advisers in line with the provision of the 1999 Constitution. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Mozambique: Fight Against HIV Costs 350 Million Dollars a Year
[AIM] Maputo -The fights against the HIV/ADS epidemic in Mozambique has, in recent years, cost an average of 350 million US dollars a year. (Source: AllAfrica News: HIV-Aids and STDs)
Botswana: Can the Past Heal the Present?
[Botswana Daily News] Gaborone -What can modern society learn from the past? Can the past constitute a key part of modern society and how can it be infused in a post-modern society without upsetting the jigsaw that is today's generations? (Source: AllAfrica News: HIV-Aids and STDs)
Workplace factors and prevalence of low back pain among male commercial kitchen workers.
CONCLUSIONS: Results suggest that to undertake further studies on different preventive measures and ergonomics intervention to reduce the risks of LBP among kitchen workers. PMID: 25322740 [PubMed - as supplied by publisher] (Source: Journal of Back and Musculoskeletal Rehabilitation)
Use of the lateral fluoroscopic view to identify a safe starting point and trajectory lines when placing percutaneous iliosacral screws.
Authors: Stinner DJ, Mir HR Abstract Safe percutaneous placement of iliosacral screws remains a challenge given the close proximity to neurovascular structures. Because of the concerns with safe placement, surgeons have explored the use of three-dimensional fluoroscopy and intraoperative computed tomography-guided screw placement with success; however, these intraoperative aids are not readily available and, in some cases, are cost prohibitive. The authors present a surgical technique that varies from the standard technique for placement of percutaneous iliosacral screws by utilizing the lateral sacral view at the start of the procedure to identify the appropriate starting point and trajectory lines, which aid in obtaining fluoroscopic imaging and guiding pin advancement. Use of th...
Longitudinal Studies: An Essential Component for Complex Psychiatric Disorders
Publication date: Available online 5 June 2015 Source:Neuroscience Research Author(s): Melvin G. McInnis , John F. Greden Most psychiatric syndromes are chronic and lifetime in course. Kraepelin's seminal work pointed out a century ago that longitudinal/lifetime assessments were powerful aids in differentiating dementia praecox from manic-depressive disorder. Despite this, clinical research investigations in psychiatry have historically emphasized short-term and cross-sectional approaches. This review of an array of longitudinal studies supports that they are arguably an essential component of psychiatric investigations, but that they must be coupled with other approaches. The use of standardized, validated, repeated assessments in a disease over the course of time must be incorporated w...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
AIDSinfo Updates Consumer Fact Sheets on HIV Treatment
The updated AIDSinfo consumer fact sheets provide important information on HIV treatment. Each fact sheet includes a summary of key points and links to additional information and resources. &nbsp; View or download the following fact sheets in the treatment series: HIV Treatment: The Basics Just Diagnosed: Next Steps After Testing Positive for HIV When to Start Antiretroviral Therapy What to Start: Selecting a First HIV Regimen FDA-Approved HIV Medicines Drug Resistance HIV Medication Adherence Following an HIV Regimen: Steps to Take Before and After Starting HIV Medicines HIV and Immunizations Visit infoSIDA to view the fact sheets in Spanish. (Source: AIDSinfo At-a-Glance: Offering Information on HIV/AIDS Treatment, Prevention, and Research, A Service of the U.S. Depar...
Starting Antiretroviral Treatment Early Improves Outcomes for HIV-Infected Individuals
&ldquo;A major international randomized clinical trial has found that HIV-infected individuals have a considerably lower risk of developing AIDS or other serious illnesses if they start taking antiretroviral drugs sooner, when their CD4+ T-cell count&mdash;a key measure of immune system health&mdash;is higher, instead of waiting until the CD4+ cell count drops to lower levels. Together with data from previous studies showing that antiretroviral treatment reduced the risk of HIV transmission to uninfected sexual partners, these findings support offering treatment to everyone with HIV. &nbsp; &ldquo;The new finding is from the&nbsp;Strategic Timing of AntiRetroviral Treatment (START) study, the first large-scale randomized clinical trial to establish that earlier antiretroviral treatment ben...
June 8 is Caribbean-American HIV/AIDS Awareness Day
On June 8, join AIDSinfo&nbsp;in observing Caribbean-American HIV/AIDS Awareness Day. According to the&nbsp;U.S Agency for International Development (USAID), outside of sub-Saharan Africa, the Caribbean region has the highest HIV prevalence in the world. Caribbean-American HIV/AIDS Awareness Day highlights the burden of HIV throughout the region and promotes the spread of information about HIV/AIDS to Caribbean Americans.&nbsp; Explore our&nbsp;Caribbean-American HIV/AIDS Awareness Day webpage&nbsp;[en espa&ntilde;ol] to learn more about the observance and to find region-specific information about HIV/AIDS. (Source: AIDSinfo At-a-Glance: Offering Information on HIV/AIDS Treatment, Prevention, and Research, A Service of the U.S. Department of Health and Human Services (DHHS))
National Library of Medicine Announces Solicitation of Quotations for the 2015 HIV/AIDS Community Information Outreach Projects
The National Library of Medicine (NLM) is pleased to announce the solicitation of quotations from organizations and libraries to design and conduct projects for improving HIV/AIDS information access for patients and the affected community as well as their caregivers and the general public. Patients and the affected community need access to the most up-to-date and accurate health information to effectively manage and make informed decisions about their health. Health care providers and health educators also need access to the most current information to provide the highest quality of care. NLM is committed to assisting organizations in accessing the spectrum of information resources and services that are currently available. The NLM is particularly interested in proposals with creative and ...
Systematic Review of Decision Aids for Newly Diagnosed Prostate Cancer Patients Making Treatment Decisions
The objective of this study was to systematically review decision aids for their content, development process, effectiveness and potential for implementation in routine urologic practice for newly diagnosed prostate cancer patients. (Source: The Journal of Urology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Bigger foot: Kaposi?s sarcoma
A normal CD4+ T cell count does not preclude opportunistic infection in an HIV-positive patient. This point was illustrated by the evaluation of a 33-year-old African American man with a history of asymptomatic HIV-1 infection. He presented to the Johns Hopkins Bayview Medical Center after 2 days of fever, chills, right lower-extremity pain, erythema, and swelling. His CD4+ T cell count was 774 cells/?L on presentation, and he had no history of treatment with highly active antiretroviral therapy (HAART) or of an AIDS-defining illness. (Source: The American Journal of Medicine)
Motivation and satisfaction among community health workers in Morogoro Region, Tanzania: nuanced needs and varied ambitions
Conclusion and recommendationsA combination of financial and non-financial incentives is required to support motivation and satisfaction among CHWs. Although CHWs joined mainly due to their altruistic nature, they became discontented with the lack of monetary compensation, transportation and communication support received. With the planned rollout of the national CHW cadre, improved understanding of CHWs as a heterogeneous group with nuanced needs and varied ambitions is vital for ensuring sustainability. (Source: Human Resources for Health)
Peer review plan for Updated Recommendations for Human Immunodeficiency Virus (HIV) Testing of Gay, Bisexual and Other Men who have Sex with men (MSM) in Health-Care Settings.
This report will outline the current scientific data regarding testing MSM for HIV and provide updated recommendations for the frequency of testing for this group. The report will not address frequency of testing for persons other than MSM in the United States. (Source: CDC HIV/AIDS Prevention)
New high-res 3D MRI map aids surgeons
Researchers at Duke University have created an ultrahigh-resolution 3D MRI (more) (Source: AuntMinnie.com Headlines)
HIV/AIDS Community Information Outreach Project 2015
Solicitation of quotations from organizations and libraries to design and conduct projects for improving HIV/AIDS information access for patients and the affected community as well as their caregivers and the general public. (Source: PHPartners.org)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Zimbabwe: HIV Treatment and Infection Prevention and Control Practices in Health Care Facilities
[U.S. Embassy Harare] U.S. and Zimbabwe Partner to Improve HIV Treatment and Infection Prevention and Control Practices in Health Care Facilities (Source: AllAfrica News: HIV-Aids and STDs)
Thirty years of AIDS data highlight survival gains, room for improvement
Although treatment advances have dramatically reduced deaths from opportunistic infections related to AIDS, a new study drawing on 30 years of data from more than 20,000 patients in San Francisco suggests there is still ample room to improve. About a third -- 35 percent -- of AIDS patients diagnosed with their first opportunistic infection from 1997 to 2012 in that city died within five years, according to the study. (Source: ScienceDaily Headlines)
South Africa: Basic Education Extends Comment Period for Draft National Policy On HIV, STI's and TB
[SA Govt] The Department of Basic Education (DBE) has extended the period for public comment on the Departments Draft National Policy on HIV, STI's and TB, due to the public interest expressed by many South Africans and various stakeholders in education. The initial comment period closed on Tuesday 26 May 2015 and has now been extended to Friday 19 June 2015. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: Assessing the HIV/Aids MDGs - Does This Look Like Success or Even Progress?
[Fahamu] One of the MDGs is to reduce sexual transmission of HIV by 50 percent by 2015. But new infections are outpacing scaled up treatment, basic knowledge about HIV is poor, only about 35 percent of those infected receive treatment, and only about 40 percent of people living with HIV know their status. (Source: AllAfrica News: HIV-Aids and STDs)
Ethiopia: Joining Hands Against HIV and Aids, Gender Inequality Featured
[Ethiopian Herald] A number of factors such as poverty and patriarchal social structure have been preventing women in Ethiopia from protecting themselves from the deadly diseases such as HIV and AIDS and seizing empowerment by their own right. Many organizations working on the area are attempting to make a difference in this regard. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Schmid on Ryan White
When the Ryan White Care Act was passed 25 years ago, Congress was responding to a national health emergency that was overwhelming our Nation, particularly hospitals and health clinics in large urban areas.  People were dying because there were no effective long lasting treatments and the only option was just AZT.  Emergency funding was needed to help pay for hospital beds, doctors and nurses, drugs, hospice care, and the city and state public health systems that were struggling to respond to the epidemic.   A lot has changed since 1990 thanks to the courageous people living with HIV and their families and friends, who not only endured sickness and death, but also stigma, discrimination, and unnecessary shame. Leadership in our government by giants such as Sens. Ted Kennedy and Orin Hat...
What advancements in the treatment of HIV/AIDS should be celebrated during the anniversary of the Ryan White Care Act?
Schmid on Ryan White Submitted by Ali on Thu, 06/04/2015 - 04:13 When the Ryan White Care Act was passed 25 years ago, Congress was responding to a national health emergency that was overwhelming our Nation, particularly hospitals and health clinics in large urban areas.  People were dying because there were no effective long lasting treatments and the only option was just AZT.  Emergency funding was needed to help pay for hospital beds, doctors and nurses, drugs, hospice care, and the city and state public health systems that were struggling to respond to the epidemic.   Share Email Print var switchTo5x = false;var __st_loadLate = true;stLight.options({"publisher":"dr-e0d16a36-b72f-d979-d8a1-314a351971a6"});...
Botswana: Pat On the Back for NACA
[Botswana Daily News] Gaborone -Public Accounts Committee (PAC) has commended the National AIDS Coordinating Agency (NACA) for its sterling work. (Source: AllAfrica News: HIV-Aids and STDs)
Total ankle replacement.
CONCLUSION: Total ankle replacement is a good treatment option for complete, end-stage ankle arthritis. It can restore joint function and make the patient mobile with little or no pain. There are, however, many contraindications to be taken into account. There is a need for further studies of the biomechanics of arthritic and replaced ankle joints and for long-term follow-up studies of total ankle replacement. PMID: 25837859 [PubMed - in process] (Source: Deutsches Arzteblatt International)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Deworming the world.
Authors: Olds GR Abstract Worms or helminths have historically infected more than half the world's population, but were largely neglected by medical science and public health interventions because they were considered non-fatal and of minimal clinical significance. During the 1980s, several oral drugs that were originally developed for veterinary use were discovered to cure, in a single dose, most human helminth infections. This allowed the first systematic population-based studies of the morbid sequelae of chronic worm infection and their potential reversibility after treatment. Based on these studies, we now know that almost all infected children and many adults, particularly pregnant and lactating women, suffer adverse effects from worms, including growth stunting, anemia, decre...
Rational design of vaccines for AIDS and influenza.
Authors: Nabel GJ Abstract Successful immunization against challenging infectious diseases requires novel approaches to vaccine design. To control diseases of high human health impact such as AIDS and influenza by vaccination requires an understanding of the mechanisms of viral entry and identification of highly conserved vulnerable regions of the virus to which immune responses are not normally directed. Structural biology has provided important information about the three-dimensional organization and chemical structure of the HIV-1 and influenza glycoproteins. By harnessing structural biology, monoclonal antibody specificity, genomics, and informatics, we have been able to define neutralizing antibodies of exceptional breadth and potency against circulating strains of HIV-1, and ...
Hemophilia: an amazing 35-year journey from the depths of HIV to the threshold of cure.
Authors: White GC Abstract Methods developed in the early 1970s to highly purify factor VIII (FVIII) from the plasma of large numbers of blood donors led, for the first time, to concentrates of FVIII that enabled hemophiliac to self-treat, providing independence and opening the way to safe surgery and other treatments. But, with the introduction of blood-borne viruses such as HIV-1 and hepatitis C viruses into the blood supply, these concentrates also transmitted HIV and hepatitis to a high percentage of hemophiliacs. Nevertheless, from the depths of the AIDS epidemic in hemophilia came extraordinary scientific advances that led to recombinant FVIII, the identification of HIV as the agent causing AIDS, the eventual development of effective treatments for AIDS, gene transfer approac...
Crofelemer: In HIV Associated Diarrhea and Secretory Diarrhea - A Patent Perspective.
CONCLUSION: Crofelemer is a first-in-class agent that possesses a unique mechanism of action through dual inhibition of both the intestinal chloride channels in secretory diarrhea. PMID: 25851117 [PubMed - in process] (Source: Recent Patents on Anti-Infective Drug Discovery)
Magnitude of Anemia and Associated Factors among Pediatric HIV/AIDS Patients Attending Zewditu Memorial Hospital ART Clinic, Addis Ababa, Ethiopia.
Conclusion. Anemia was more prevalent and severe in patients with low CD4+ T cell counts, patients infected with intestinal parasites/helminthes, and HAART naïve patients. Therefore, public health measures and regular follow-up are necessary to prevent anemia. PMID: 25878898 [PubMed] (Source: Anemia)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Excellent clinical outcomes and retention in care for adults with HIV-associated Kaposi sarcoma treated with systemic chemotherapy and integrated antiretroviral therapy in rural Malawi.
CONCLUSIONS: The NKSC model resulted in infrequent adverse events, low loss to follow-up and excellent OS. Our results suggest it is safe, effective and feasible to provide standard-of-care chemotherapy regimens from the developed world, integrated with ART, to treat HIV-KS in rural Malawi. Baseline BMI and haemoglobin may represent important patient characteristics associated with HIV-KS survival in rural sub-Saharan Africa. PMID: 26028156 [PubMed - in process] (Source: Journal of the International AIDS Society)
Estimated age and gender profile of individuals missed by a home-based HIV testing and counselling campaign in a Botswana community.
CONCLUSIONS: The HBHTC campaign seems to be an efficient tool for reaching individuals who have never been tested previously in southern African communities. However, about half of men from 16 to 64 years old were not reached by the HBHTC, including about 60% of men between 30 and 40 years old. Alternative HTC strategies should be developed to bring these men to care, which will contribute to reduction of HIV incidence in communities. PMID: 26028155 [PubMed - in process] (Source: Journal of the International AIDS Society)
Wide Data Sharing Poses Problems With ConsentWide Data Sharing Poses Problems With Consent
Current regulations for obtaining consent from study participants have not kept up with big data, and researchers are grappling with how to protect privacy as data get shared and uses evolve. Medscape Medical News (Source: Medscape Hiv-Aids Headlines)
A report from the Conference on Retroviruses and Opportunistic Infections (CROI) 2015 (February 23-26 - Seattle, Washington, USA).
Authors: Rabasseda X Abstract The largest conference on HIV and AIDS, the annual Conference on Retroviruses and Opportunistic Infections (CROI) also encompasses opportunistic and other important pathogens, notably in 2015 hepatitis C virus and the Ebola virus. This year's conference involved 4 days of discussions on highly relevant basic, translational and clinical research and developments in the ongoing battle against these infections. PMID: 25876564 [PubMed - in process] (Source: Drugs of Today)
XB130 expression in human osteosarcoma: a clinical and experimental study.
Authors: Wang X, Wang R, Liu Z, Wang L, Li Y, Zhang L, Huang H, Guo W Abstract The purpose of this study was to identify prognostic factors for osteosarcoma (OS) aids in the selection of patients who require more aggressive management. XB130 is a newly-characterized adaptor protein, which was reported to be a prognostic factor of certain tumor types. However, the association between XB130 expression and the prognosis of OS remains unknown. In the present study, we investigated the association between XB130 expression and clinicopathologic features and prognosis in patients suffering from OS, and further investigated XB130's potential role on OS cells in vitro and vivo. A retrospective immunohistochemical study of XB130 was performed on archival formalin-fixed paraffin-embedded spec...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Thirty years of AIDS data highlight survival gains, room for improvement
(Infectious Diseases Society of America) Although treatment advances have dramatically reduced deaths from opportunistic infections related to AIDS, a new study drawing on 30 years of data from more than 20,000 patients in San Francisco suggests there is still ample room to improve. About a third -- 35 percent -- of AIDS patients diagnosed with their first opportunistic infection from 1997 to 2012 in that city died within five years, according to the study, published in the Journal of Infectious Diseases. (Source: EurekAlert! - Infectious and Emerging Diseases)
Mario Cooper, Nexus Between AIDS Activists and Black Leaders, Dies at 61
Mr. Cooper was a former Democratic political operative who pressed civil rights groups to confront H.I.V.?s effect. (Source: NYT Health)
Validation of the Hebrew and Arabic Versions of the Outcome Questionnaire (OQ-45).
CONCLUSIONS: Adequate psychometric properties of the Hebrew and Arabic OQ-45 suggest that they can serve as useful measures of mental health treatment in Israel.Further research is necessary to confirm norms, cut-off scores and sensitivity-to-change using a larger representative population and diverse types of treatment over a longer period of time. PMID: 25841108 [PubMed - in process] (Source: Israel Journal of Psychiatry and Related Sciences)
High immune activation and abnormal expression of cytokines contribute to death of SHIV89.6-infected Chinese rhesus macaques
In this study, we found that 6 of 14 SHIV89.6-infected CRMs died within 127 weeks after infection. We found especially high immune activation, low IFN-? expression, and distinctive cytokine expression profiles in the infected and dead (ID) group of monkeys, while there was only few change in the CD4+ T counts and distribution of T cell subsets in the ID group monkeys. Also, there was a similar dynamic of viral load between infected and surviving (IS) and ID group monkeys. Furthermore, we found various correlations among immune activation, IFN-? expression, and frequencies of cytokine-secreting cells. These results suggest that SHIV89.6 infections have pathogenic potential in CRMs and that high immune activation and abnormal expression of cytokines contribute to death of SHIV89.6-infecte...
Viruses, Vol. 7, Pages 2816-2833: Hydrogen Peroxide Induce Human Cytomegalovirus Replication through the Activation of p38-MAPK Signaling Pathway
Human cytomegalovirus (HCMV) is a major risk factor in transplantation and AIDS patients, which induces high morbidity and mortality. These patients infected with HCMV experience an imbalance of redox homeostasis that cause accumulation of reactive oxygen species (ROS) at the cellular level. H2O2, the most common reactive oxygen species, is the main byproduct of oxidative metabolism. However, the function of H2O2 on HCMV infection is not yet fully understood and the effect and mechanism of N-acetylcysteine (NAC) on H2O2-stimulated HCMV replication is unclear. We, therefore, examined the effect of NAC on H2O2-induced HCMV production in human foreskin fibroblast cells. In the present study, we found that H2O2 enhanced HCMV lytic replication through promoting major immediate early (MIE) promo...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
High Prevalence of Assisted Injection Among Street-Involved Youth in a Canadian Setting
This study uses a multivariate generalized estimating equation to identify factors associated with receiving assistance with injecting among a cohort of street-involved youth aged 14?26 in Vancouver, Canada. A total of 253 participants reported injecting drugs during the study period, and 49 % (n = 125) of these youth reported receiving assistance with injecting in the past 6 months. In multivariate analysis, younger age, female gender, binge drug use, heroin injecting, cocaine injecting, crystal methamphetamine injecting, and syringe sharing were positively and independently associated with assisted injection (all p &lt; 0.05). These findings underscore the need for expanding substance abuse treatment alongside HIV prevention and health promotion interventions to empower youth to ...
Erratum to: Southern Africa: the Highest Priority Region for HIV Prevention and Care Interventions
(Source: Current HIV/AIDS Reports)
[Requirements for low vision magnification aids in age-related macular degeneration : Data from the Tübingen low vision clinic (comparison of 2007-2011 with 1999-2005)].
CONCLUSION: There is an unchanged and still high demand for rehabilitation aids of AMD patients, for dry as well as for neovascular AMD even after the introduction of anti-vascular endothelial growth factor (anti-VEGF) therapy. PMID: 26040791 [PubMed - as supplied by publisher] (Source: Der Ophthalmologe)
Biomedical Applications of Polymers Derived by Reversible Addition - Fragmentation Chain-Transfer (RAFT).
Authors: Fairbanks BD, Gunatillake T, Meagher L Abstract RAFT- mediated polymerization, providing control over polymer length and architecture as well as facilitating post polymerization modification of end groups, has been applied to virtually every facet of biomedical materials research. RAFT polymers have seen particularly extensive use in drug delivery research. Facile generation of functional and telechelic polymers permits straightforward conjugation to many therapeutic compounds while synthesis of amphiphilic block copolymers via RAFT allows for the generation of self-assembled structures capable of carrying therapeutic payloads. With the large and growing body of literature employing RAFT polymers as drug delivery aids and vehicles, concern over the potential toxicity of RA...
Opportunistic infections among individuals with HIV-1/AIDS in the highly active antiretroviral therapy era at a Quaternary Level Care Teaching Hospital
CONCLUSIONS : OIs remain frequent in the ART era even in populations where the access to medical care is considered satisfactory. (Source: Revista da Sociedade Brasileira de Medicina Tropical)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
An information-centric framework for designing patient-centered medical decision aids and risk communication.
Authors: Franklin L, Plaisant C, Shneiderman B Abstract Risk communication is a major challenge in productive patient-physician communication. Patient decision making responsibilities come with an implicit assumption that patients are sufficiently educated and confident in their abilities to make decisions about their care based on evidence based treatment recommendations. Attempts to improve health literacy in patients by way of graphical decision aids have met with success. Such decision aids typically have been designed for a general population and evaluated based on whether or not users of the decision aid can accurately report the data points in isolation. To classify decision aids, we present an information-centric framework for assessing the content delivered to patients. We...
Pseudomonas aeruginosa on vinyl-canvas inflatables and foam teaching aids in swimming pools.
Authors: Schets FM, van den Berg HH, Baan R, Lynch G, de Roda Husman AM Abstract Swimming pool-related Pseudomonas aeruginosa infections mainly result in folliculitis and otitis externa. P. aeruginosa forms biofilms on surfaces in the swimming pool environment. The presence of P. aeruginosa on inflatables and foam teaching aids in 24 public swimming pools in the Netherlands was studied. Samples (n = 230) were taken from 175 objects and analysed for P. aeruginosa by culture. Isolated P. aeruginosa were tested for antibiotic resistance by disk diffusion. P. aeruginosa was detected in 63 samples (27%), from 47 objects (27%) in 19 (79%) swimming pools. More vinyl-canvas objects (44%) than foam objects (20%) were contaminated, as were wet objects (43%) compared to dry objects (13%). Con...
Determination of effort required to insert a rescue tube into various grain types.
Conclusions drawn from the study included documentation that as the moisture content of the grain increases, the amount of resistance against tube insertion increases substantially. It was found that although the moisture content may be similar across several types of grain, the amount of work required to insert a rescue tube into the grain can vary. It was also concluded that the cohesiveness, angle of internal friction, and static coefficient of friction of the grain on the tube surface, which vary with moisture content and type of grain, were primary factors affecting the amount of effort needed to insert the tube. This article recommends that a consensus standard be developed covering the design and testing of grain rescue tube containment systems. PMID: 23189516 [PubMed - indexed ...
The U.S. Department of Labor's Tractor and Machinery Certification Program: management styles and perceptions held by community stakeholders and instructors.
Authors: Jepsen SD Abstract A mixed-mode, descriptive study was conducted on the U.S. Department of Labor's (DOL) Tractor and Machinery Certification Program. Legislated by the Fair Labors Standards Act, the Hazardous Occupations Order in Agriculture (HOOA) was enacted in 1968 as a public policy measure to reduce the number of injuries to youth on farms. An educational exemption allows youth 14 and 15 years of age to work for hire after they successfully complete a training program. In the 40+ years since the legislation went into effect prescribing such training exemptions, deficiencies and variations have occurred in the quality of the educational program and the system by which agencies certify young people. To gain a better understanding of the DOL Tractor and Machinery Certifi...
Consensus document on the management of renal disease in HIV-infected patients.
CONCLUSIONS: Renal function should be monitored in all HIV-infected patients. The information provided in this document should enable clinicians to optimize the evaluation and management of HIV-infected patients with renal disease. PMID: 25467377 [PubMed - in process] (Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
HIV and risk behaviour among men who have sex with men in Slovakia (2008-2009).
Authors: Staneková D, Kramárová P, Wimmerová S, Hábeková M, Taká?ová M, Mojzesová M Abstract The HIV infection remains a major public health issue in the world and especially in those countries where there exists unprotected sexual intercourse between people of the same sex. It is namely the category of men having sex with men (MSM) that still represents a group at high risk of being infected with HIV or transmitting the virus. The aim of our study was to present HIV 2nd generation surveillance data on MSM in Slovakia in the period between the years 2008 and 2009. Time-location sampling (TLS) was used to recruit participants and oral fluid samples together with completed anonymous questionnaires were collected simultaneously. The oral fluids were tested with use of the Ge...
Public awareness about diabetes: cross sectional study of Lithuania's residents.
CONCLUSIONS: Study findings suggest the potential social stigmatization of diabetes and encourage looking for new ways in approaching the community as well as individual diabetic patients in regard to the issue of diabetes. PMID: 25622478 [PubMed - indexed for MEDLINE] (Source: Central European Journal of Public Health)
Outcome of antiretroviral treatment in patients with AIDS monoinfection and those co-infected with hepatitis B and C viruses and tuberculosis in Ukraine.
Authors: Radchuk OM, Chentsova NP, Tukaiev SV Abstract Antiretroviral therapy reduces AIDS morbidity and mortality as well as decreases HIV transmission by reducing the viral load (VL). We aimed to determine the rate of immunological and virological failure that reflects antiretroviral treatment (ART) effectiveness among the patients of the Kyiv City AIDS Centre and may lead to ART switch in the future. In 59% of patients the prescribed ATR regimen was regarded as successful, in 37% as unsuccessful and 4% of patients were excluded for lacking sufficient follow-up time. Among the cases of unsuccessful ART, the largest part of patients was experiencing secondary immunological failure, on the second place was primary immunological failure. The temporal distribution of primary and seco...
WHO calls for stronger focus on adolescent health. Road traffic injuries, HIV/AIDS, suicide are top causes of death; depression is number 1 cause of illness and disability.
Authors: PMID: 25230544 [PubMed - indexed for MEDLINE] (Source: Central European Journal of Public Health)
Adolescents falling through gaps in HIV services. For World Aids Day 2013, who launches new HIV recommendations to increase testing, counselling, treatment and care for this neglected group.
Authors: PMID: 24592731 [PubMed - indexed for MEDLINE] (Source: Central European Journal of Public Health)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Transactional sex and HIV risks - evidence from a cross-sectional national survey among young people in Uganda.
CONCLUSIONS: Transactional sex is associated with sexual coercion and HIV risk behaviors such as multiple concurrent sexual partnerships among young people in Uganda. In addition, transactional sex appears to place young men at increased risk for HIV in Uganda. Both sexes appear equally vulnerable to risks associated with transactional sex, and therefore should be targeted in intervention programs. In addition, strengthening universal education policy and improving school retention programs may be beneficial in reducing risky sexual behaviors and transactional sex. PMID: 26001780 [PubMed - in process] (Source: Global Health Action)
Causes of death in the Taabo health and demographic surveillance system, Côte d'Ivoire, from 2009 to 2011.
CONCLUSIONS: Communicable diseases remain the predominant cause of death in rural Côte d'Ivoire. Based on these findings, measures are now being implemented in the Taabo HDSS. It will be interesting to monitor patterns of mortality and causes of death in the face of rapid demographic and epidemiological transitions in this part of West Africa. PMID: 25959772 [PubMed - in process] (Source: Global Health Action)
HIV-related knowledge, perceptions, attitudes, and utilisation of HIV counselling and testing: a venue-based intercept commuter population survey in the inner city of Johannesburg, South Africa.
CONCLUSION: The overall HIV/AIDS knowledge was generally high. Gender-specific health education and HIV intervention programmes are needed for improved access to HCT services. One favourable intervention would be the use of home-based HCT programmes. PMID: 25925192 [PubMed - in process] (Source: Global Health Action)
Review of HIV response in Pakistan using a system thinking framework.
Authors: Abdullah MA, Shaikh BT Abstract Pakistan has moved from a 'low prevalence-high risk' to a 'concentrated epidemic' state, yet the forcefulness required for managing this silent escalation of HIV infected numbers is not being highlighted, as it should be. A more comprehensive review of the national strategy for HIV/AIDS would necessitate a system's thinking. For this purpose, the WHO's Health Systems Building Blocks have been discussed to analyse whether this framework can be employed to take some corrective measures. An extensive literature review in this regard helps to understand that the service delivery has to be responsive, but skilled human resources, a robust information system, an uninterrupted supplies and use of latest technology, adequate financing, and above all...
The impact of flooding on people living with HIV: a case study from the Ohangwena Region, Namibia.
CONCLUSIONS: This study demonstrates that vulnerabilities and health risks of PLWHIV will increase in a disaster situation like flooding if access to HIV prevention, treatment, care and support are not addressed and ensured. The findings and the HIV and Flooding Framework are not specific to Ohangwena and can be transferred to any flood-affected region that has a high HIV prevalence and relies mainly on subsistence agriculture. They serve as a model case for analysing vulnerabilities related to health and health service provision under disaster conditions. The impact will vary according to the physical, geographical, climatological, social, and behavioural characteristics of the region and the people affected. In the Ohangwena region, a disaster risk management mechanism is already in plac...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
The role of major donors in health aid to the Democratic People's Republic of Korea.
This study highlights the valuable role of the ROK in the flow of health aid to the DPRK, especially in light of the DPRK's precarious international status. Although global health aid from many international organizations has decreased, organizations such as GFATM and UNFPA continue to maintain their focus on reproductive health and infectious diseases. PMID: 23766869 [PubMed - indexed for MEDLINE] (Source: Journal of Preventive Medicine and Public Health)
Aneurysmal vasculopathy in human-acquired immunodeficiency virus-infected adults: Imaging case series and review of the literature.
CONCLUSION: Patients with HIV/AIDS who have aneurysmal and stenotic vascular disease may benefit from earlier surveillance with the onset of neurological symptoms. The roles of medical, open surgical, and endovascular therapy in this unique entity will be further defined as the pathological basis of the disease is better understood. PMID: 26023074 [PubMed - as supplied by publisher] (Source: Interventional Neuroradiology)
NLM Solicits Quotations for 2015 HIV/AIDS Community Information Outreach Projects
The National Library of Medicine (NLM) is pleased to announce the solicitation of quotations from organizations and libraries to design and conduct projects for improving HIV/AIDS information access for patients and the affected community as well as their caregivers and the general public. Patients and the affected community need access to the most up-to-date and accurate health information to effectively manage and make informed decisions about their health.  Health care providers and health educators also need access to the most current information to provide the highest quality of care. NLM is committed to assisting organizations in accessing the spectrum of information resources and services that are currently available. The NLM is particularly interested in proposals with creative an...
Cipla gets USFDA nod for Lopinavir, Ritonavir oral pellets
Cipla has received approval from US health regulator USFDA for Lopinavir and Ritonavir oral pellets used for treating AIDS in infants and young children. (Source: The Economic Times Healthcare and Biotech News)
Tanzania: HIV-Aids War in Top Rythm As 25 Million Tested
[Daily News] Dodoma -NEARLY half of the population has voluntarily tested for HIV/Aids due to various efforts and strategies put in place, with the HIV prevalence going down from 5.8 per cent in 2008 to 5.3 in 2012. (Source: AllAfrica News: Health and Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Gambia: Lrr Has the Highest HIV & Aids Prevalence
[Foroyaa] Speaking at the national launching of the Trans- Gambia Corridor Road Construction Project last week at the Baobab Holiday Resort in Bijilo, the Executive Director of the National Aids Secretariat (NAS), Mr. Ousman Badjie, said the latest surveys on HIV/ AIDS prevalence in The Gambia indicate that the Lower River Region (LRR), for the past few years, is the hardest hit region. (Source: AllAfrica News: HIV-Aids and STDs)
Morocco: HM the King Hands Donation of Two Tons of Medicines to Ivorian Anti-Aids Program
[MAP] Abidjan -HM King Mohammed VI handed, Tuesday at the University Hospital Center of Yopougon in Abidjan, a donation of two tons of medicines to the Ivorian Anti-Aids Program. (Source: AllAfrica News: Health and Medicine)
Sexual Relationships and PrEP Adherence and Adherence GapsSexual Relationships and PrEP Adherence and Adherence Gaps
How do different sexual relationships affect adherence to HIV pre-exposure prophylaxis? JAIDS: Journal of Acquired Immune Deficiency Syndromes (Source: Medscape Today Headlines)
HIV/AIDS Community Information Outreach Projects 2015
The National Library of Medicine (NLM) is pleased to announce the solicitation of quotations from organizations and libraries to design and conduct projects for improving HIV/AIDS information access for patients and the affected community as well as their caregivers and the general public. Patients and the affected community need access to the most up-to-date and accurate health information to effectively manage and make informed decisions about their health. Health care providers and health educators also need access to the most current information to provide the highest quality of care. NLM is committed to assisting organizations in accessing the spectrum of information resources and services that are currently available.  The NLM is particularly interested in proposals with creative an...
Informal HIV Caregiver Proxy Reports of Care Recipients? Treatment Adherence: Relationship Factors Associated with Concordance with Recipients? Viral Suppression
Abstract To explore the role of informal caregivers in adherence, we compared adherence reports by caregivers to those of care recipients. We identified individual-level and relationship factors associated with agreement between caregivers? reports of recipients? adherence and assessed viral suppression. Participants were care recipients, who were on ART and had ever injected drugs, and their caregivers (N = 258 dyads). Nearly three-fourths of caregivers? reports of recipients? ART adherence agreed with recipients? viral suppression status. Agreement was associated with recipient age and expressing affection or gratitude to the caregiver, caregiver?s having been close to someone who died of HIV/AIDS, and caregiver?s fear of caregiving-related HIV (re)infection,...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
HIV Stigma in Prisons and Jails: Results from a Staff Survey
Abstract With numerous HIV service gaps in prisons and jails, there has been little research on HIV stigma attitudes among correctional staff. Such attitudes may undermine HIV services for inmates at risk of or infected with HIV. This HIV stigma attitudes survey among 218 correctional staff in 32 US facilities (1) provides an overview of staff?s stigma attitudes, (2) reports psychometric analyses of domains in Earnshaw and Chaudoir?s HIV Stigma Framework (HSF), and (3) explores differences in stigma attitudes among different staff types. Overall, correctional and medical staff expressed non stigmatizing attitudes toward people living with HIV/AIDS, but perceived that stigma and discrimination exist in others. Factor analyses revealed a three factor structure capturing two mech...
Factors Influencing Uptake of Rapid HIV and Hepatitis C Screening Among Drug Misusing Adult Emergency Department Patients: Implications for Future HIV/HCV Screening Interventions
Abstract In this randomized, controlled trial among 957 English- or Spanish-speaking drug misusing adult emergency department (ED) patients, we determined if a tailored brief intervention (BI) increased uptake of rapid HIV/HCV screening, and identified factors associated with greater screening uptake. Rapid HIV/HCV screening uptake was greater in the control than the BI arm (45 vs. 38 %; p &lt; 0.04). Screening uptake depended on elapsed study time and which research staff member offered testing. In the control arm, uptake was lowest for those spending &lt;30 or ?90 min in the study. In the BI arm, screening uptake generally increased over time. Tailored BI content specifically addressing participant HIV/HCV knowledge, HIV/HCV risk behaviors, or need for HIV/HCV screening wa...
[Switching within the active ingredient group or changing the mechanism of action : Data situation by failure of the first line biologic].
Authors: Rubbert-Roth A Abstract Despite the use of biologics many patients do not achieve remission or reduced disease activity, which raises the question of the optimal therapy when these therapy targets are not achieved. Most data from clinical studies and registry data refer to the approach following the unsuccessful use of one or more tumor necrosis factor (TNF) inhibitors. Randomized controlled studies investigating the effectiveness of a further biologic or TNF inhibitor in patients who received abatacept, tocilizumab or rituximab in the first line therapy are currently lacking, with the exception of the German MIRAI study. The majority of registry data and observational studies suggest that when the use of a TNF inhibitor is unsuccessful it is advantageous to change to a no...
NICE aids the search for evidence
Following the closure of the DARE service, systematic reviews published in PubMed from 1 January 2015 are now added to NICE Evidence Search. (Source: NHS Networks)
Internet?based treatment of stress urinary incontinence: 1? and 2?year results of a randomized controlled trial with a focus on pelvic floor muscle training
ConclusionNon?face?to?face treatment of SUI with PFMT provides significant and clinically relevant improvements in symptoms and condition?specific QoL at 1 and 2 years after treatment. (Source: BJU International)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Life changes in women infected with HIV by their husbands: An interpretive phenomenological study
HIV transmission from husbands to wives in stable marital relationships has increased. Our study explored women?s perspectives on their life changes after being infected with HIV by their husbands. The interpretive phenomenological approach guided the study. Cambodian women (n = 15) who self-identified their infections as coming from their husbands participated in 2 in-depth interviews. The participants underwent significant changes in interpersonal and intimate relationships with their spouses, reporting that their partners became more devoted husbands and agreed to follow safer sex practices within the marriage. (Source: Journal of the Association of Nurses in AIDS Care)
Improving and sustaining a reduction in iatrogenic pneumothorax through a multifaceted quality?improvement approach
CONCLUSIONSA multidisciplinary team, focused on evidence, patient safety, and standardization, can use a set of multifaceted interventions to sustainably improve patient outcomes for several years after implementation. Our hospital was in the highest performance UHC quartile for all?cause IAP in 2012 to 2014. Journal of Hospital Medicine 2015. © 2015 Society of Hospital Medicine (Source: Journal of Hospital Medicine)
Synthetic vectors for gene delivery: An overview of their evolution depending on routes of administration.
Authors: Belmadi N, Midoux P, Loyer P, Passirani C, Pichon C, Le Gall T, Jaffres PA, Lehn P, Montier T Abstract Nucleic acid delivery constitutes an emerging therapeutic strategy to cure various human pathologies. This therapy consists of introducing genetic material into the whole body or isolated cells to correct a cellular abnormality or disfunction. As with any drug, the main objective of nucleic acid delivery is to establish optimal balance between efficacy and tolerance. The methods of administration and the vectors used are selected depending on whether the goal of treatment is the production of an active protein; the replacement of a missing or inactive gene; or the combat of acquired diseases, such as cancer or AIDS. In that sense, synthetic vectors represent a valuable so...
A Deeper Look at Three Emerging Areas in Neovascular AMDA Deeper Look at Three Emerging Areas in Neovascular AMD
Recent advances in the fields of pharmacologic treatments, surgically implanted visual aids, and diagnostics all look to reshape the clinical treatment of AMD in coming years. Medscape Ophthalmology (Source: Medscape Today Headlines)
Can Your Brain Really Be "Full"?
Neuroimaging aids investigation into what happens in the brain when we try to remember information that&rsquo;s very similar to what we already know -- Read more on ScientificAmerican.com (Source: Scientific American - Official RSS Feed)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
1 in 5 Younger Americans Tested for HIV
22 percent for females and 16 percent for males, CDC says Source: HealthDay Related MedlinePlus Pages: HIV/AIDS, Health Screening, Health Statistics (Source: MedlinePlus Health News)
Nigeria: Funds Allocated for HIV/Aids Not Enough to Stop Spread
[Daily Trust] Insufficient fund allocated by the federal government to reduce the spread of HIV/AIDS and treat persons living with the virus would delay its goal to ensure a free HIV/AIDS generation. (Source: AllAfrica News: Health and Medicine)
Cameroon: UNAIDS Boss Appreciates Cameroon's Efforts On Mother-to-Child Transmission of HIV
[Cameroon Tribune] The Joint United Nations Programme on HIV/AIDS, UNAIDS, Executive Director, Michel Sidibe, has appreciated the vision of the Chantal Biya International Reference Centre for Research on HIV/AIDS Prevention and Management (CIRCB) and African Synergy Against AIDS and Suffering, for research to curb mother-to-child transmission of HIV and also the care and treatment given to children suffering from the disease. He made the statement yesterday, June 1, 2015 while visiting the headquarters of African Synergy Aga (Source: AllAfrica News: Health and Medicine)
Cameroon: Cameroon's Stability, Leadership On Fight Against HIV/Aids Hailed
[Cameroon Tribune] The Executive Director of UNAIDS, Michel Sidibe, was received in audience by Prime Minister Philemon Yang yesterday in Yaounde. (Source: AllAfrica News: Health and Medicine)
Cameroon: Fight Against HIV - Cameroon's First Lady Receives Special Attribute
[Cameroon Tribune] Cameroon's First Lady, Mrs Chantal Biya has been attributed the merit of UNAIDS Special Ambassador. In the presence of the President of the Republic, Paul Biya, the Joint United Nations Programme on HIV/AIDS, UNAIDS, Executive Director, Michel Sidibe, handed the certificate of recognition and the award placard to Mrs Chantal Biya, yesterday June 1, 2015 at the Oriental Pavilion of the Unity Palace. (Source: AllAfrica News: Health and Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Cameroon: Truck Drivers Sensitised On HIV/Aids
[Cameroon Tribune] The campaign among long-distance truck drivers was launched in Awae near Yaoundé on Sunday May 31, 2015. (Source: AllAfrica News: Health and Medicine)
Zimbabwe: HIV and Aids Remain a Major Challenge, Says Gen Chiwenga
[The Herald] HIV and aids remains a major challenge in the country, especially in the uniformed forces, the Commander of the Defence Forces, General Constantine Chiwenga has said. (Source: AllAfrica News: Health and Medicine)
Krokodile Injectors in Ukraine: Fueling the HIV Epidemic?
This study was designed to assess the characteristics of krokodile injectors, a recent phenomenon in Ukraine, and HIV-related risk factors among people who inject drugs (PWID). In three Ukraine cities, Odessa, Donetsk and Nikolayev, 550 PWID were recruited between December 2012 and October 2013 using modified targeted sampling methods. The sample averaged 31 years of age and they had been injecting for over 12 years. Overall, 39 % tested positive for HIV, including 45 % of krokodile injectors. In the past 30 days, 25 % reported injecting krokodile. Those who injected krokodile injected more frequently (p &lt; 0.001) and they injected more often with others (p = 0.005). Despite knowing their HIV status to be positive, krokodile users did not reduce their injection frequency, indee...
1 in 5 Younger Americans Tested for HIV
22 percent for females and 16 percent for males, CDC says (Source: Fertility News - Doctors Lounge)
Single-molecule manipulation of the gp41 complex [Biophysics and Computational Biology]
HIV-1 glycoprotein 41 (gp41) mediates viral entry into host cells by coupling its folding energy to membrane fusion. Gp41 folding is blocked by fusion inhibitors, including the commercial drug T20, to treat HIV/AIDS. However, gp41 folding intermediates, energy, and kinetics are poorly understood. Here, we identified the folding intermediates of... (Source: Proceedings of the National Academy of Sciences)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
From Moral Reflexes to Ethical Reflection: Ethical Commentary on the Refusal of Cardiac Surgery in Patients with Intravenous Drug Abuse, Active Hepatitis C, or HIV/AIDS
Thorac cardiovasc SurgDOI: 10.1055/s-0035-1551680Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Full text (Source: The Thoracic and Cardiovascular Surgeon)
A longitudinally extensive myelopathy in a patient with AIDS.
Authors: Hardy SJ, Benavides DR, Thakur KT, Probasco JC, Pardo CA PMID: 26038583 [PubMed - as supplied by publisher] (Source: Practical Neurology)
June Issue of NIH News in Health Now Available
The June issue of NIH News in Health is now available. Featured stories include "HIV and AIDS: Know the Facts" and "Talking With Your Doctor: Make the Most of Your Appointment". Also, check out the health capsules and the featured Web site. (Source: What's New on MedlinePlus)
How to Address Smoking Cessation in HIV PatientsHow to Address Smoking Cessation in HIV Patients
What are the most effective strategies available to help HIV positive patients quit smoking? HIV Medicine (Source: Medscape Today Headlines)
Zimbabwe: Aids Levy Raises Millions to Fund Zimbabwe's HIV Response
[Key Correspondents] A senior Zimbabwean health official has revealed how money collected through the country's AIDS levy is funding the national response to HIV. In 2014 the government collected US$38.65 million through the levy, which is an income-based tax. (Source: AllAfrica News: Health and Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Women living with HIV/AIDS (WLHA), battling stigma, discrimination and denial and the role of support groups as a coping strategy: a review of literature
Conclusion: Support groups should be offered as a fundamental part of HIV/AIDS services and should be advocated as an effective and useful intervention. Further research is needed to examine the effect of support groups for women living with HIV/AIDS. A community based randomised controlled trial with support group as an intervention and a control group could provide further evidence of the value of support groups. (Source: BioMed Central)
June 2015
HIV and AIDS: Know the Facts: Treatments Work, but Prevention Is Key...Talking With Your Doctor: Make the Most of Your Appointment...Mapping Language Problems in the Brain...Healthy and Fun Family Recipes...Featured Web Site: NIH?s National Cancer Institute (Source: NIH News in Health)
Decision aids for people facing health treatment or screening decisions
No abstract available (Source: International Journal of Evidence-Based Healthcare)
Mark Cuban Foundation aids U-M research on growth hormone's impact on ACL recovery
(University of Michigan Health System) Funding from the Mark Cuban Foundation, run by the well-known owner of the Dallas Mavericks, will allow University of Michigan researchers to study how human growth hormone may aid recovery from an ACL tear. (Source: EurekAlert! - Social and Behavioral Science)
Evaluating the National HIV/AIDS Strategy: Making Room for Families
The White House Office of National AIDS Policy released the National HIV/AIDS Strategy (NHAS) in 2010 as the domestic response to an illness that currently impacts over 1 million Americans. The policy aims to decrease HIV infections, improve health outcomes, and reduce health disparities, and outlines efforts that will be taken to reach these goals. Although it remains the most comprehensive national policy to date, the NHAS neglects to consider the familial context and includes no family-centered approaches to prevention and care. In this article, the policy will be evaluated with recommendations about how family-centered care can be incorporated into the NHAS goals and interventions. Research, practice, and advocacy recommendations for professional counselors and marriage and family ther...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
High-Risk Cardiac Surgery in Patients with Intravenous Drug Abuse and/or Active Hepatitis C or HIV Infection: An Ethical Discussion of Six Cases
Conclusion?Decision making in noncompliant drug addicts with recurrent prosthesis infection and in HIV-positive patients leads beyond surgical challenges to ethical and economic considerations.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: The Thoracic and Cardiovascular Surgeon)
FAmily CEntered (FACE) advance care planning: Study design and methods for a patient-centered communication and decision-making intervention for patients with HIV/AIDS and their surrogate decision-makers
Although the Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) has become a chronic illness, disease-specific advance care planning has not yet been evaluated for the palliative care needs of adults with HIV/AIDS. This prospective, longitudinal, randomized, two-arm controlled clinical trial aims to test the efficacy of FAmily CEntered Advance Care Planning among adults living with AIDS and/or HIV with co-morbidities on congruence in treatment preferences, healthcare utilization, and quality of life. (Source: Contemporary Clinical Trials)
Using tools and technology to promote education and adherence to oral agents for cancer.
Authors: Burhenn PS, Smudde J Abstract BACKGROUND: The use of oral agents for cancer (OACs) is increasing, and oncology nurses are in an ideal position to educate patients about them and suggest methods to improve adherence. Once an OAC is ordered, the administration is the responsibility of the patient. Oncology nurses can use tools and technology to assist with education, which may promote adherence, and suggest reminder tools that can be used. Many electronic tools have been developed, such as smartphone applications, text messaging, electronic alarms, and glowing pill bottles. OBJECTIVES: The researchers reviewed electronic devices, as well as traditional methods such as calendars and pillboxes, that can assist patients in remembering to take the medication they are adminis...
Development and piloting of a decision aid for women considering participation in the Sentinel Node Biopsy versus Axillary Clearance 2 breast cancer trial.
CONCLUSION: The development and two-stage piloting process for this decision aid resulted in a resource that women found very acceptable and helpful in assisting decision-making about SNAC-2 trial participation. The process and findings provide a guide for developing other trial decision aids. PMID: 26033878 [PubMed - as supplied by publisher] (Source: Clinical Trials)
High-Risk Cardiac Surgery in Patients with Intravenous Drug Abuse and/or Active Hepatitis C or HIV Infection: An Ethical Discussion of Six Cases.
Conclusion?Decision making in noncompliant drug addicts with recurrent prosthesis infection and in HIV-positive patients leads beyond surgical challenges to ethical and economic considerations. PMID: 26030119 [PubMed - as supplied by publisher] (Source: The Thoracic and Cardiovascular Surgeon)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
HIV/AIDS and the South African State: Sovereignty and the Responsibility to Respond.
Authors: PMID: 26041090 [PubMed - in process] (Source: Australian and New Zealand Journal of Public Health)
Health disparities in liver disease in Sub?Saharan Africa
This article is protected by copyright. All rights reserved. (Source: Liver International)
Reprint of: Barriers to accessing low-vision care: the patient's perspective.
CONCLUSIONS: The reasons for not accessing LV rehabilitation are complex, and some may be more easily addressed than others. A heightened awareness of LV rehabilitation may be achieved with better communication by eye care professionals and with public education. The stigma associated with the usage of LV aids and admitting a disability still seems to exist, but may be reduced by increasing societal understanding of LV. PMID: 26049889 [PubMed - as supplied by publisher] (Source: Canadian Journal of Ophthalmology)
Cell?mediated anti?Gag immunity in pharmacologically induced functional cure of simian AIDS: a ?bottleneck effect??
ConclusionsRestriction of immune activation through auranofin/BSO may result in stochastic selection of cell clones targeting conserved epitopes leading to a functional cure?like condition. (Source: Journal of Medical Primatology)
The Bonebridge Bone Conduction Hearing Implant: Indication criteria, surgery and a systematic review of the literature
ConclusionThe transcutaneous bone conduction implant system Bonebridge provides a valuable and stable audiological benefit to patients suffering from conductive or mixed hearing loss and single sided deafness. With its active transcutaneous design the Bonebridge offers a lower complication rate to percutaneous systems and higher and more reliable hearing gain compared to other transcutaneous or percutaneous systems. Moreover the fast activation of the implant system enables the recipient of the system to benefit in a short time frame postoperatively from the intervention.This article is protected by copyright. All rights reserved. (Source: Clinical Otolaryngology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Measurement and comparison of health utility assessments in chronic rhinosinusitis
ConclusionCRS patients show significant impairment in QOL, with health utility values similar to those of patients with acquired immune deficiency syndrome (AIDS) or intermittent claudication using similar methods. The method of ascertainment significantly affects measured health utility, but the degree of impairment warrants improved recognition and appropriate treatment of the condition. (Source: International Forum of Allergy and Rhinology)
Global Public Awareness of Venous Thromboembolism
ConclusionsOn a global level, public awareness about thrombosis overall, and of VTE in particular, is low. Campaigns to increase public awareness about VTE are needed to reduce the burden from this largely preventable thrombotic disorder.This article is protected by copyright. All rights reserved. (Source: Journal of Thrombosis and Haemostasis)
Analysis of CCR5 and SDF?1 genetic variants and HIV infection in Indian population
In this study, the SDF1?3?A polymorphism, CCR5?32 polymorphism and CCR5 promoter polymorphism at positions 58934 G/T, 59029 G/A, 59353 T/C, 59356 C/T, 59402 A/G and 59653 C/T were analysed in Indian population. The polymorphisms in HIV?1 patients and healthy individuals were evaluated by conventional PCR, RFLP?PCR and direct sequencing techniques. The CCR5?32 mutant allele was found to be almost absent in Indian population. The analysis of the CCR5?59356C/T polymorphism revealed a trend towards an association of the C allele with an increased risk of HIV?1 infection. The frequency of allele CCR5?59356C was higher in HIV?1 patients (100%) as compared to healthy control subjects (89%, P = 0.003). The correlation of SDF1?3?A and CCR5 promoter CCR5?58934G/T, CCR5?...
Cross?sectional study on socio?demographic and clinical correlates of depression among human immunodeficiency virus?positive patients in Surat City, Western India
This study attempts to assess the magnitude of depression and the socio?demographic and clinical variables associated with it in HIV?positive patients. MethodsA cross?sectional study was conducted in 270 HIV?positive patients using Beck Depression Inventory (BDI; translated and validated in Gujarati and Hindi) along with a questionnaire for eliciting information on socio?demographic and clinical variables. ResultsThe prevalence of depression among HIV?positive patients was 30% with 12.22% having mild depression; 14.07% with moderate depression and 3.7% with severe depression. Bivariate analysis showed that physical pain, physical illness, Cluster of Differentiation 4 (CD4) &lt;300 cells/mm3, HIV positive spouse, discrimination at hospital, discrimination in society, government ...
Methadone continuation versus forced withdrawal on incarceration in a combined US prison and jail: a randomised, open-label trial
Publication date: Available online 28 May 2015 Source:The Lancet Author(s): Josiah D Rich , Michelle McKenzie , Sarah Larney , John B Wong , Liem Tran , Jennifer Clarke , Amanda Noska , Manasa Reddy , Nickolas Zaller Background Methadone is an effective treatment for opioid dependence. When people who are receiving methadone maintenance treatment for opioid dependence are incarcerated in prison or jail, most US correctional facilities discontinue their methadone treatment, either gradually, or more often, abruptly. This discontinuation can cause uncomfortable symptoms of withdrawal and renders prisoners susceptible to relapse and overdose on release. We aimed to study the effect of forced withdrawal from methadone upon incarceration on individuals' risk behaviours and engagement with pos...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Implementation of community-based adherence clubs for stable antiretroviral therapy patients in Cape Town, South Africa.
CONCLUSIONS: Over a period of 18 months, a community-based model of care was rapidly implemented decentralizing more than 2000 patients in a high-prevalence, resource-limited setting. The fundamental challenge for this out of facility model was ensuring that patients receiving ART within a CAC were viewed as an extension of the facility and part of the responsibility of CHC staff. Further research is needed to support down-referral sooner after ART initiation and to describe patient experiences of community-based ART delivery. PMID: 26022654 [PubMed - in process] (Source: Journal of the International AIDS Society)
Homosexual men in HIV serodiscordant relationships: implications for HIV treatment as prevention research.
CONCLUSIONS: Levels of HIV transmission risk and incidence were high, particularly in early relationships. Rates of relationship break-up were high. These data suggest that studies of HIV treatments and transmission in homosexual serodiscordant couples should focus on early relationships so as not to underestimate risk, and sample sizes must allow for high rates of relationship break-up. PMID: 26015387 [PubMed - in process] (Source: Journal of the International AIDS Society)
Angola: Over 180 Cases of HIV/Aids Diagnosed in Cuito
[ANGOP] Kuito -At least 182 new cases of HIV/AIDS were diagnosed by health authorities of the city of Cuito during the first quarter of this year, in health facilities and Voluntary Counselling and Testing Centres (CATV) in the area. (Source: AllAfrica News: Health and Medicine)
Translating an Evidence-Based Behavioral Intervention for Women Living with HIV into Clinical Practice: The SMART/EST Women?s Program
Conclusion This study confirmed (a) the ?translatability? of the Stress Management And Relaxation Training/Emotional Supportive Therapy (SMART/EST) Women?s Program, from academic to CHC settings in two geographic regions with high HIV prevalence among women, (b) the ability of local staff (using the ?train the trainer? model) to successfully achieve program fidelity and clinical outcomes, and (c) the sustainability the program beyond the auspices of research support, through supportive CHC leadership securing continued program funding. (Source: International Journal of Behavioral Medicine)
Barriers and Facilitators to HIV Testing in Migrants in High-Income Countries: A Systematic Review
Abstract Migrants, particularly from low- and middle-income countries, are at a heightened risk of adverse HIV outcomes. HIV testing may improve these outcomes. We reviewed and synthesised studies into migrants and HIV testing (outcome variable), published between January 1997 and April 2014. Papers using quantitative, qualitative and mixed methods designs, and samples with adult (?18 years) migrants from low- and middle-income countries in high-income countries were included in the paper. Of 3155 papers retrieved, 31 met the inclusion criteria and are included in the review. A large number of barriers and facilitators to HIV testing were identified across the individual, social and structural levels. A number of study design and methodological issues, however, inhibited a ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Protecting 50 Years of Child Health Progress
It was a generation ago that Harry Truman said, and I quote him: 'Millions of our citizens do not now have a full measure of opportunity to achieve and to enjoy good health. Millions do not now have protection or security against the economic effects of sickness. And the time has now arrived for action to help them attain that opportunity and to help them get that protection.' ... The need for this action is plain; and it is so clear indeed that we marvel not simply at the passage of this bill, but what we marvel at is that it took so many years to pass it. President Lyndon B. Johnson said this as he signed Medicaid into law on July 30, 1965, thanking former President Harry S. Truman and the many members of Congress from both parties who laid the groundwork and worked tirelessly to m...
Updated Fact Sheet: Condom Distribution as a Structural Level Intervention
This fact sheet presents scientific support for condom distribution programs, strategic planning considerations for implementing structural-level condom distribution programs, and examples of successful condom distribution programs. (Source: CDC HIV/AIDS Prevention)
HIV Surveillance in Urban and Nonurban Areas (through 2013)
This slide sets presents HIV surveillance data for urban and nonurban areas of the United States. The Centers for Disease Control and Prevention uses the Office of Management and Budget?s system, which designates metropolitan statistical areas (MSAs). Areas are divided into MSAs of populations of 500,000 or more; 50,000 to 499,999; and nonmetropolitan (less than 50,000). (Source: CDC HIV/AIDS Prevention)
[Perspectives] An anthropology of aid in Africa
We have been working as medical anthropologists in Mozambique for more than two decades. On a recent trip, we visited several large clinics in central Mozambique where HIV/AIDS first surged 20 years ago. In a health centre in a poor peri-urban bairro in Chimoio, a maternal and child health (MCH) nurse was tasked with the impossible job of providing most of the antenatal, maternity, labour and delivery, child-at-risk, and well child care since the other nurses were out sick or on leave. Filing cabinets were falling apart so patient records could not be properly archived. (Source: LANCET)
South Africa: Minister Aaron Motsoaledi Accepts ENCA Apology for ARV Treatment Programme Story
[SA Govt] Health Minister Dr Aaron Motsoaledi has today welcomed an apology by eNCA for broadcasting a story under the headline "TAC sounds alarm on shortage of ARV's on 19 May 2015. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Medical Researcher Allen D. Allen Is Waiting...
Much of our lives are spent waiting. We wait for our hopes, plans and actions to develop, progress and mature. Allen D. Allen is a retired medical researcher and he too is waiting. He waits for the final chapter of his innovative life work. Allen waits for the implementation of a blood test that he discovered to identify major depression. Most significantly, he is waiting for a Phase III clinical trial of an antibody that can change how HIV/AIDS is treated. In life, it takes a great deal of work and effort to hurry up and wait. A Medical Researcher can be found at most university teaching hospitals. Their job is to observe and ponder. In the academic world of "publish or perish," a medical researcher is looking for an interesting topic to investigate and launch into a study. It is a jo...
Alterations in memory B cell subsets upon immunization against Streptococcus pneumoniae in HIV-1 infected adults
Conclusion Vaccination with the 23-PPV has an immunological effect on certain B cell subsets like RM and ITS memory B cells, triggering alterations of their counts on peripheral blood of HIV-infected patients. Moreover, HAART intake has controversial implication in few of these memory B cell populations. (Source: HIV and AIDS Review)
Healthcare seeking practices of People Living with HIV and AIDS (PLHIV) in Bangladesh
Conclusion The state should play an active role in providing HIV/AIDS health services for the PLHIV with the help of monitoring and assessing the integrative performances of health practitioners directed by health ministry and local administration. (Source: HIV and AIDS Review)
Sexual protective strategies and condom use in middle-age African American women: A qualitative study
This study used a qualitative approach to understand middle-age urban African American women?s experiences with HIV-related sexual risk behaviors and to identify the sexual protective strategies they employed to reduce their risk for HIV infection. Ten African American women, ages 45 to 56, were recruited from low-income neighborhoods in New York City. (Source: Journal of the Association of Nurses in AIDS Care)
The 6 thalamic regions: surgical approaches to thalamic cavernous malformations, operative results, and clinical outcomes.
CONCLUSIONS The authors have presented the largest series reported to date of surgically treated thalamic CMs, achieving excellent results using this methodology. In the authors' experience, conceptually dividing the thalamus into 6 different regions aids in the selection of the ideal surgical approach fora specific region. PMID: 26024002 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
The Role of Metacognitive Reading Strategies, Metacognitive Study and Learning Strategies, and Behavioral Study and Learning Strategies in Predicting Academic Success in Students With and Without a History of Reading Difficulties.
We examined the self-reported use of reading, study, and learning strategies in university students with a history of reading difficulties (HRD; n = 77) and with no history of reading difficulties (NRD; n = 295). We examined both between-groups differences in strategy use and strategy use as a predictive measure of academic success. Participants completed online questionnaires regarding reading history and strategy use. GPA and frequency of use of academic support services were also obtained for all students. University students with HRD reported a different profile of strategy use than their NRD peers, and self-reported strategy use was differentially predictive of GPA for students with HRD and NRD. For students with HRD, the use of metacognitive reading strategies and the use of study ai...
Regenerating lost taste buds: Key steps discovered
Researchers have discovered a key molecular pathway that aids in the renewal of taste buds, a finding that may help cancer patients suffering from an altered sense of taste during treatment. (Source: ScienceDaily Headlines)
HIV drugs more beneficial if started from diagnosis
Stephen FellerWASHINGTON, May 28 (UPI) -- A study found that starting antiretroviral drugs closer to HIV diagnosis significantly decreases the risk of developing AIDS or other serious illnesses. (Source: Health News - UPI.com)
Can Uganda end its Aids epidemic?
Can Uganda stop the epidemic? (Source: BBC News | Health | UK Edition)
South Africa: SA's ARV Programme Reducing New HIV Infections
[SAnews.gov.za] South Africa's antiretroviral (ARV) programme has significantly contributed to reducing new HIV infections and mortality from Aids, and has ensured child survival and prolonged life, according to Cabinet. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
South Africa: News Channel Apologises for Insert on Drug Shortages
[SAnews.gov.za] Health Minister Aaron Motsoaledi has called for a partnership in the fight against HIV and Aids in the wake of incorrect media reports that the country has a critical shortage of anti-retroviral drugs. (Source: AllAfrica News: HIV-Aids and STDs)
HIV treatment breakthrough shows antiretroviral drugs should be given at diagnosis
A major study carried out in 35 countries offers 'clear-cut proof' that all people diagnosed with HIV should be given treatment immediately, to lower the risk of Aids, serious illness and death. (Source: the Mail online | Health)
Nigeria: 'Hiv/Aids Fund Not Enough to Stop Spread'
[Daily Trust] The amount of monies allocated by the federal government to reduce the spread of HIV/AIDS and treat persons living with the virus would delay its goal to ensure a free HIV/AIDS generation, Dr Bilali Camara, UNAIDS Country Director for Nigeria has said. (Source: AllAfrica News: HIV-Aids and STDs)
Zimbabwe: In Incentive Funding Request, Zimbabwe Prioritizes Young People
[GFO] Most of the $40.2 million request focuses on people under age 24 (Source: AllAfrica News: HIV-Aids and STDs)
Africa: International Community Must Act to End Violence Against Women
[Key Correspondents] As the UN goes through the process of setting the post-2015 development agenda, the link between violence against women and girls and their vulnerability to HIV infection means that policymakers must do more to address this issue. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
South Africa: Start HIV Treatment Sooner, Study Shows
[GroundUp] It's important to start treating people with HIV sooner rather than later, according to the findings of a large clinical study which could change treatment in many countries including South Africa. (Source: AllAfrica News: HIV-Aids and STDs)
Mozambique: Mozambique's Drive to Control Malaria Puts Collaboration At Its Core
[GFO] Mozambique, where malaria is nationally endemic and still a major driver of mortality especially among children, is a good example of how collaboration between government, civil society and the private sector can contribute to an effective response to the disease. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: From Having a Voice to Being Heard - the Case for Professionalizing Key Population Representatives
[GFO] Among the recommendations of a recent report on the Representation and Participation of Key Populations on Country Coordinating Mechanisms (CCMs) in six African countries, Aidspan underlines the need to professionalize key population representatives (KPRs). It notes that "just because one is vocal does not necessarily translate into meaningful engagement", that KPRs "have often in the past been seen as somewhat token CCM members" and that "their ability to contribute, and the quality of their participation (Source: AllAfrica News: HIV-Aids and STDs)
Africa: At First Global Fund Partnership Forum, a Chance to Hear Africa's Voice
[GFO] The Global Fund convened the first in a series of partnership forums in the Ethiopian capital Addis Ababa on 7-8 May, seeking input from both donors and implementers into the next operational strategy for 2017-2021. (Source: AllAfrica News: HIV-Aids and STDs)
Rwanda: Police Extend Voluntary HIV Testing to Crime Preventers
[New Times] A team of medical personnel from Kacyiru Police Hospital, on May 26, completed an HIV testing programme for the Rwanda National Police (RNP) officers and District Administrative Security Support Organ, (DASSO) personnel operating in Nyamagabe District. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Global Trial Finds HIV Drugs Should Be Taken Right After Diagnosis
Those who started medications early fared better than those who waited until immune systems weakened (Source: Fertility News - Doctors Lounge)
Prevalence and Correlates of HIV Infection Among Sex Workers in Papua New Guinea: First Results from the Papua New Guinea and Australia Sexual Health Improvement Project (PASHIP)
Abstract The primary objective of this study was to estimate the individual and combined impacts of socio-demographic and sexual behaviours on HIV diagnosis among 523 female sex workers who participated in the Papua New Guinea and Australia Sexual Health Improvement Project. Logistic regression models were used to identify the factors associated with HIV positivity. We estimated their population level impacts in order to quantify the proportion of HIV seropositivity is attributed to these factors. Less than 40 % of women consented to get tested for HIV. HIV prevalence was 7 % (95 % CI 4?11 %); lack of education and knowledge/awareness of HIV accounted for ~70 % of the HIV diagnoses. A major obstacle is lack of interest for testing. Our study underscored the major challenges...
Time trends for risk of severe age-related diseases in individuals with and without HIV infection in Denmark: a nationwide population-based cohort study
Publication date: Available online 27 May 2015 Source:The Lancet HIV Author(s): Line D Rasmussen , Margaret T May , Gitte Kronborg , Carsten S Larsen , Court Pedersen , Jan Gerstoft , Niels Obel Background Whether the reported high risk of age-related diseases in HIV-infected people is caused by biological ageing or HIV-associated risk factors such as chronic immune activation and low-grade inflammation is unknown. We assessed time trends in age-standardised and relative risks of nine serious age-related diseases in a nationwide cohort study of HIV-infected individuals and population controls. Methods We identified all HIV-infected individuals in the Danish HIV Cohort Study who had received HIV care in Denmark between Jan 1, 1995, and June 1, 2014. Population controls were identified fr...
Coaching patients in the use of decision and communication aids: RE-AIM evaluation of a patient support program
Conclusion: We have sustained a clinic-wide implementation of decision and communication aids through a novel staffing model that uses paid and unpaid student interns as coaches. (Source: BMC Health Services Research)
Effects of cash transfers on Children&#8217;s health and social protection in Sub-Saharan Africa: differences in outcomes based on orphan status and household assets
Conclusion: Orphaned children are at higher risk for poor social protection outcomes even when cared for in family-based settings. UCT and CCT each produced direct effects on children?s social protection which are not moderated by other child- and household-level risk factors, but orphans are less likely to attend school or obtain birth registration. The effects of UCT and CCT are not moderated by asset-holding, but greater household assets predict greater social protection outcomes. Intervention efforts need to focus on ameliorating the additional risk burden carried by orphaned children. These efforts might include caregiver education, and additional incentives based on efforts made specifically for orphaned children. (Source: BMC Public Health)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Transitioning HIV-infected children and adolescents into adult care: An Italian real-life experience
As young people living with HIV age, transition to adult care is increasingly required. The aim of our study was to describe how a care transition program was developed in an HIV adult clinic in Genoa. This is a descriptive study including 45 HIV-infected patients who participated in the transition process from a pediatric unit to an adult Infectious Diseases Unit, which started in 2000. A dedicated day, patient-customized environment, psychological support, and all health services in 1 site were provided. (Source: Journal of the Association of Nurses in AIDS Care)
Second Chances. Surviving Aids in Uganda. Susan Reynolds Whyte, ed., Durham: Duke University Press, 2014, 297 pp.
(Source: Medical Anthropology Quarterly)
Burden of serious fungal infections in the Dominican Republic
The Dominican Republic (DR) is the second largest Caribbean nation and, with Haiti, the DR accounts for nearly three-quarters of the cases of human immunodeficiency virus (HIV) infection in the Caribbean region and the highest rates of TB in the Americas. The present study estimated the burden of serious fungal infections and some other mycoses in the DR. The data were extracted from the World Health Organization Stop Tuberculosis (WHO STOP TB) program, the Joint United Nations Program on HIV/AIDS (UNAIDS), and searches for relevant literature via MEDLINE, PubMed, MedFacts, and so on. (Source: Journal of Infection and Public Health)
RNA interference approaches for treatment of HIV-1 infection
Abstract HIV/AIDS is a chronic and debilitating disease that cannot be cured with current antiretroviral drugs. While combinatorial antiretroviral therapy (cART) can potently suppress HIV-1 replication and delay the onset of AIDS, viral mutagenesis often leads to viral escape from multiple drugs. In addition to the pharmacological agents that comprise cART drug cocktails, new biological therapeutics are reaching the clinic. These include gene-based therapies that utilize RNA interference (RNAi) to silence the expression of viral or host mRNA targets that are required for HIV-1 infection and/or replication. RNAi allows sequence-specific design to compensate for viral mutants and natural variants, thereby drastically expanding the number of therapeutic targets beyond the capabiliti...
Commercial sex behaviours among involuntary male bachelors: findings from a survey of migrants in Xi'an, China
Conclusions The higher prevalence of commercial sex behaviours and the lower frequency of condom use indicate a higher risk of disease from commercial sex among involuntary bachelors, implicating both individual and public health. (Source: Journal of Public Health)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Earlier Is Better for HIV Drug Therapy
Everyone who is infected with the virus that causes AIDS should start on drug therapy as soon as possible, according to results of a major international study released Wednesday. (Source: WSJ.com: Health)
Association of Employee Attributes and Exceptional Performance Rating at a National Center of the US Centers for Disease Control and Prevention, 2011
Conclusions: Exceptional SPR is independently associated with personal employee attributes and job settings that are not modifiable by interventions designed to improve employee performance based on accomplishments. (Source: Journal of Public Health Management and Practice)
Drugs to keep people with HIV alive should be given without delay, trial finds
Scientists in Europe and Africa find that antiretroviral treatment should be administered before HIV virus has weakened the immune system Continue reading... (Source: Guardian Unlimited Science)
Prevalence and behavioural risks for HIV and HCV infections in a population of drug users of Dakar, Senegal: the ANRS 12243 UDSEN study.
CONCLUSIONS: High HIV and HCV prevalence were estimated in this population of DUs (including non-injectors) living in the Dakar area, Senegal, whereas HBV prevalence was close to that of the global Senegalese population, reflecting a risk of infection independent of drug use. Women seem to be highly vulnerable and deserve targeted interventions for decreasing exposure to HIV, while behavioural risk factors for HIV and HCV include the use of unsafe injections, reflecting the urgent need for developing harm reduction interventions and access to opioid substitution therapy services. PMID: 26004637 [PubMed - in process] (Source: Journal of the International AIDS Society)
Targeting Pre-Exposure Prophylaxis Among MSMTargeting Pre-Exposure Prophylaxis Among MSM
What targeting strategies are most effective when implementing pre-exposure prophylaxis among men who have sex with men? JAIDS: Journal of Acquired Immune Deficiency Syndromes (Source: Medscape Today Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Namibia: Stigmatisation Blights Male Circumcision
[New Era] Elim Constituency councillor Gerhard Shiimi has urged men to get circumcised in order to prevent the spread of HIV that leads to AIDS. (Source: AllAfrica News: HIV-Aids and STDs)
South Africa: Durban to Host 2016 Aids Conference
[News24Wire] The eThekwini Municipality will host the International Aids Conference in 2016, it was announced on Tuesday. (Source: AllAfrica News: HIV-Aids and STDs)
Tanzania: Legislator Calls for Sex Work Ban in Zanzibar
[Daily News] Zanzibar -AMID fears that HIV prevalence in Zanzibar is increasing, Ms Ashura Sharif Ali (Special Seats- CUF) has suggested that women and men engaged in commercial sex should be banned in the islands. (Source: AllAfrica News: HIV-Aids and STDs)
South Africa: Mixed Reactions Over Condoms in Schools
[The Herald] Johannesburg -South Africa's Department of Basic Education (DBE) is considering distributing condoms to primary and secondary schools as part of the government's move to curb the prevalence of HIV, but there are mixed reactions over the proposal. (Source: AllAfrica News: HIV-Aids and STDs)
Botswana: Mayor Takes HIV Test Publicly
[Botswana Daily News] Gaborone -Gaborone mayor, Mr Kagiso Thutlwe, on May 23, took an HIV test publicly in an effort to encourage the public to follow suite. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Nigeria: 160,000 Nigerian Adolescents HIV Positive - NACA
[Leadership] A report presented by Ms Victoria Isiramen of the National Agency for the Control of AIDS (NACA), has revealed that about 160,000 Nigerian adolescents are infected with the HIV virus while 11,000 have died from the epidemic. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: Country Not Doing Enough to Fight HIV/Aids - UNAIDS
[Premium Times] The country director, Joint United Nations Programme on HIV/AIDS, Bilali Camara, on Tuesday said Nigeria requires $1.2bn (N236.4 trillion) for the treatment of HIV/AIDS in Nigeria. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: Country Needs U.S.$1.2 Billion to Treat HIV/Aids - UNAIDS
[Guardian] Dr Bilali Camara, Country Director, Joint United Nations Programme on HIV/AIDS (UNAIDS), on Tuesday said Nigeria required $1.2bn (N236.4 trillion) for the treatment of HIV/AIDS in the country. (Source: AllAfrica News: HIV-Aids and STDs)
Starting antiretroviral treatment early improves outcomes for HIV-infected individuals
(NIH/National Institute of Allergy and Infectious Diseases) A major international randomized clinical trial has found that HIV-infected individuals have a considerably lower risk of developing AIDS or other serious illnesses if they start taking antiretroviral drugs sooner, when their CD4+ T-cell count--a key measure of immune system health -- is higher, instead of waiting until the CD4+ cell count drops to lower levels. (Source: EurekAlert! - Medicine and Health)
Identification and Evaluation of Cochlear Implant Candidates with Asymmetrical Hearing Loss
Conclusions: The panellists agreed on a clear differentiation between AHL and SSD CI candidates, defining average pure-tone thresholds up to 4 kHz for better and poorer ears. Agreement was reached on a minimum set of assessment procedures, and included the necessity of trials with conventional CROS/BICROS hearing aids and bone conduction devices before considering CI treatment. Objective assessment of sound localisation abilities was identified as the most relevant criterion to quantify performance before and after treatment. In parallel, subjective assessment of overall hearing ability was recommended via the Speech, Spatial and Qualities of hearing questionnaire. Longitudinal follow-up of these parameters and the hours of daily use were considered essential to reflect the potential treat...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Escherichia coli 6-phosphogluconate dehydrogenase aids in tellurite resistance by reducing the toxicant in a NADPH-dependent manner
Publication date: Available online 18 May 2015 Source:Microbiological Research Author(s): J.M. Sandoval , F.A. Arenas , J.A. García , W.A. Díaz-Vásquez , M. Valdivia-González , M. Sabotier , C.C. Vásquez Exposure to the tellurium oxyanion tellurite (TeO3 2?) results in the establishment of an oxidative stress status in most microorganisms. Usually, bacteria growing in the presence of the toxicant turn black because of the reduction of tellurite (Te4+) to the less-toxic elemental tellurium (Te0). In vitro, at least part of tellurite reduction occurs enzymatically in a nicotinamide dinucleotide-dependent reaction. In this work, we show that TeO3 2? reduction by crude extracts of Escherichia coli overexpressing the zwf gene (encoding glucose-6-phosphate dehydrogenase) takes place p...
Impact of a web-based treatment decision aid for early-stage prostate cancer on shared decision-making and health outcomes: study protocol for a randomized controlled trial
This study will describe a web-based prostate cancer treatment DA with VCMs. The effect of this DA on the decisionmaking process and subsequent patient reported outcomes will be evaluated.Trial registrationThe Netherlands National Trial Register: NTR4554, registration date 1 May 2014. (Source: Trials)
High-resolution, handheld camera use for occult breast lesion localization plus sentinel node biopsy (SNOLL): A single-institution experience with 186 patients
Discussion This combination of procedures represents an improvement in the surgical management of occult breast carcinomas and is the method of choice for accurate tumor localization and SLN biopsy. Handheld cameras have the potential to become highly useful intraoperative aids. (Source: The Surgeon)
Diplomatic advantages & threats in global health program selection, design, delivery and implementation: the development and application of the Kevany Riposte
Conclusions: Global health interventions stand to generate significant diplomatic advantages for donor and recipient countries and organizations when appropriately selected, designed, targeted, and delivered. Conversely, in the absence of the application of standards such as those developed under the Kevany Riposte, threats to diplomacy and international relations may occur. With the application of related systems to other global health programmes and settings, comparative results on the relative worth of alternate approaches from the diplomatic perspective may be generated to better inform political, strategic, and global health policy and programmatic decisions. (Source: Globalization and Health)
Tracking Global Fund HIV/AIDS resources used for sexual and reproductive health service integration: case study from Ethiopia
Conclusions: Showing high value for money is important for maximizing impact and replenishments. The Global Fund should routinely track HIV/AIDs grant expenditures to disease control, service integration, and overall health systems strengthening. The current PBF system will not allow this. Real-time expenditure analysis could be achieved by integrating existing activity-based financial data into the routine PBF system. The GF?s New Funding Model and the 2012-2016 strategy present good opportunities for over-hauling the PBF system to improve transparency and allow the GF to monitor and maximize value for money. (Source: Globalization and Health)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Delay and Probability Discounting of Sexual and Monetary Outcomes in Individuals with Cocaine Use Disorders and Matched Controls
by Matthew W. Johnson, Patrick S. Johnson, Evan S. Herrmann, Mary M. Sweeney Individuals with cocaine use disorders are disproportionately affected by HIV/AIDS, partly due to higher rates of unprotected sex. Recent research suggests delay discounting of condom use is a factor in sexual HIV risk. Delay discounting is a behavioral economic concept describing how delaying an event reduces that event?s value or impact on behavior. Probability discounting is a related concept describing how the uncertainty of an event decreases its impact on behavior. Individuals with cocaine use disorders (n = 23) and matched non-cocaine-using controls (n = 24) were compared in decision-making tasks involving hypothetical outcomes: delay discounting of condom-protected sex (Sexual Delay Discounting Task), d...
Diplomatic advantages and threats in global health program selection, design, delivery and implementation: development and application of the Kevany Riposte
Conclusions: Global health interventions stand to generate significant diplomatic advantages for donor and recipient countries and organizations when appropriately selected, designed, targeted, and delivered. Conversely, in the absence of the application of standards such as those developed under the Kevany Riposte, threats to diplomacy and international relations may occur. With the application of related systems to other global health programmes and settings, comparative results on the relative worth of alternate approaches from the diplomatic perspective may be generated to better inform political, strategic, and global health policy and programmatic decisions. (Source: Globalization and Health)
Community-based organizations and the aids epidemic in Amazonas state, Brazil
Este estudo objetivou analisar a percepção que as Organizações da Sociedade Civil fazem de sua contribuição na história do enfrentamento à AIDS, no Amazonas. Trata-se de pesquisa qualitativa com uso de fontes documentais e orais. Os dados foram coletados entre junho e setembro de 2013. Utilizou-se técnica de entrevistas com roteiro semiestruturado com as lideranças de oito organizações que trabalham/trabalharam com grupos mais vulneráveis. A partir da análise do discurso, concluiu-se que com a descentralização de recursos do Departamento de DST, AIDS e Hepatites Virais para as Coordenações locais, as Organizações reconhecem dois momentos distintos: um primeiro momento de fortalecimento organizacional, engajamento coletivo e participação política ativa; e um momento a...
Post-diagnosis abortion in women living with HIV/Aids in the south of Brazil
Discussion: The analysis of the reproductive trajectory of the women studied showed that there is no specific profile of the woman who aborts after receiving the HIV diagnosis. Although this diagnosis may be involved in the decision to terminate a pregnancy, it does not necessarily result in the end of a woman's reproductive trajectory. Thus, abortion should be understood within a diversity of decision-making processes and the specific moment of a woman's life story. Objetivo: Compreender como o diagnóstico de HIV se conjuga com outros fatores que concorrem para a decisão pelo aborto. Metodologia: Os dados são provenientes de um estudo transversal, com mulheres de 18 a 49 anos, que frequentavam serviços públicos de saúde, em Porto Alegre. As trajetórias de vida de 18 entrevistadas q...
Sierra Leone: Global Fund Boss Assures Health and Sanitation Minister
[Sierra Leone Government] Geneva -In 2014, Sierra Leone received from the Global Fund an allocation of US$ 126 million to fight HIV/AIDS, TB, and Malaria. But in order to access the funds the country needed to submit an application in the form of a Concept Note to the Global Fund. The Concept Note would then be reviewed by a special committee of the Global Fund, the Technical Review Panel (TRP). The TRP makes recommendations to the Board of the Global Fund which approves commitments and subsequent disbursements to countries. (Source: AllAfrica News: Health and Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Zimbabwe: Male Involvement Crucial to Prevent HIV Infection of Babies
[Key Correspondents] Preventing transmission of HIV from mothers to their babies is a huge global priority in the HIV response, but until recently the importance of involving men has not been recognised. (Source: AllAfrica News: HIV-Aids and STDs)
Hearing loss in developing countries: Canada, Google fund creative innovations
(Terry Collins Assoc) Investments of CDN$2.3 million (US$1.85 million) from sources in Canada and the USA, including Grand Challenges Canada and Google.org, will enable two Canadian organizations address hearing loss in developing countries.Not-for-profit World Wide Hearing Foundation International will develop a diagnostic kit for rural use. And a new company, Hearing Access World, will screen and quickly equip people with high-quality hearing aids at a fraction of the usual $2,000-$3,000 cost. (Source: EurekAlert! - Medicine and Health)
Adverse Drug Reactions and Clinical Outcomes in Patients Initiated on Antiretroviral Therapy: A Prospective Cohort Study From Ethiopia
Conclusions ADRs were common within the first 3 months in patients initiated on ART. Severe ADRs were negatively associated with self-reported adherence and gain in BMI. Measures need to be implemented to routinely monitor for severe ADRs to improve ART adherence and treatment outcomes. (Source: Drug Safety)
Is Photodynamic Diagnostic Flexible Ureterorenoscopy Suitable for a Patient presenting with Chronic Actinic Dermatitis?
This article is protected by copyright. All rights reserved. (Source: Photodermatology, Photoimmunology and Photomedicine)
Speech intelligibility tests and analysis of confusions and perceptual representations of Thai initial consonants
Publication date: Available online 19 May 2015 Source:Speech Communication Author(s): Charturong Tantibundhit , Chutamanee Onsuwan We methodically designed and developed a subjective intelligibility testing of Thai speech for initial consonants based on the diagnostic rhyme test (DRT). The Thai DRT for initials (TDRT-I) was designed to equally compare 21 phonemes pairwise, which results in 210 stimulus pairs. The test is well-constructed using real monosyllabic words. TDRT-I have main advantages in that percent intelligibility scores in each stimulus pair as well as confusion patterns across all phonemes can be evaluated and compared. To confirm its validity, we carried out a series of experiments. The subjective intelligibility tests were conducted on 28 Thai normal hearing listeners in...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Organic wine safety: UPLC-FLD determination of Ochratoxin A in Southern Italy wines from organic farming and winemaking
Publication date: January 2016 Source:Food Control, Volume 59 Author(s): Fausto Gentile , Giovanna Loredana La Torre , Angela Giorgia Potortì , Marcello Saitta , Maria Alfa , Giacomo Dugo A fast reversed-phase UPLC method was utilized for Ochratoxin A (OTA) determination in 55 different wine samples (red and white) produced in Southern Italy, during two vintages. All the samples came from vineyards in which the plants were subjected to organic farming and were produced according to an organic winemaking, following strict rules on processing aids. Analytical methods included the clean-up purification by using commercial immunoaffinity columns and an Acquity UPLC® system equipped with a fluorescent detector; the sensitivity of the analytical method was 0.01 ng mL?1. OTA was detected ...
Ear malformations, hearing loss and hearing rehabilitation in children with Treacher Collins syndrome.
CONCLUSIONS: Treacher Collins syndrome is characterized by bilateral malformations of the outer and middle ear. Hearing rehabilitation in these children is of utmost importance, and bone-anchored hearing aids is the method of choice. PMID: 26025357 [PubMed - as supplied by publisher] (Source: Acta Otorrinolaringologica Espanola)
Malawi: NAC Gives Blantyre Cbos K6.5 Million
[Malawi News Agency] Blantyre -Twenty four Community Based Organisations ( CBOs) from Blantyre on Thursday received cheques totaling K6, 522, 497 from the National Aids Commission-NAC towards activities in the HIV and AIDS response. (Source: AllAfrica News: HIV-Aids and STDs)
Darunavir and Trimethoprim-Sulfamethoxazole Cross-ReactivityDarunavir and Trimethoprim-Sulfamethoxazole Cross-Reactivity
This study examines the cross-reactivity between both drugs. AIDS (Source: Medscape Today Headlines)
Pneumocystis pneumonia in HIV-positive patients in Spain: epidemiology and environmental risk factors.
CONCLUSIONS: PCP was a significant health problem in the cART era (1997 to 2011), and PCP epidemiology was adversely influenced by colder climatological factors and higher ambient air pollution levels. PMID: 25997453 [PubMed - as supplied by publisher] (Source: Journal of the International AIDS Society)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
South Africa: Country Short of Children's ARVs
[News24Wire] While South Africa had a shortage of antiretrovirals for children, fixed-dose antiretrovirals were in adequate supply, Health Minister Aaron Motsoaledi said in Pretoria on Sunday. (Source: AllAfrica News: HIV-Aids and STDs)
South Africa: Health Department Investigates 'Forced' HIV-Aids Tests
[News24Wire] The Gauteng health department is investigating claims that some Johannesburg clinics have been forcing patients to undergo HIV/Aids tests. (Source: AllAfrica News: HIV-Aids and STDs)
Liberia: UNDP, UNAIDS Back Efforts to Secure Access to Treatment
[FrontPageAfrica] Geneva -The United Nations Development Programme (UNDP) and the Joint United Nations Programme on HIV/AIDS (UNAIDS) would like to call attention to the urgent and compelling case for the international community to take all measures possible to protect the health of people living in least-developed countries (LDCs). (Source: AllAfrica News: HIV-Aids and STDs)
South Africa: No Shortage of Fixed-Dose Combination ARVs in SA
[SAnews.gov.za] Government has strongly denied media reports that the country is experiencing extreme drug shortages, particularly fixed-dose combination (FDC) anti-retroviral drugs. (Source: AllAfrica News: HIV-Aids and STDs)
Malawi: Exit Mchape and Chambe, Enters Wizika - Malawian Herbalist Claims to Cure HIV
[Malawi24] A mystery 'wonder herb' Wizika has been discovered for the cure of HIV. This follows claims by a Chintheche based Malawi herbalist, Dr Writing Zigowe Kaunda together with an American Scientist Dr Jeffy Metzger who have discovered the drug for the fight against the deadly virus. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Malawi: Get to Know - Malawian Herbalist Claiming to Have Found HIV Cure
[Malawi24] Meet Dr Writing Zigowe Kaunda, a Malawian herbalist who together with an American Scientist Dr Jeffy Metzger have discovered the drug for the fight against the deadly virus, HIV. (Source: AllAfrica News: HIV-Aids and STDs)
Early diagnosis of HIV among men who have sex with men in Western Australia: impact of a peer-led sexually transmissible infection testing service
Byron C. Minas, Carolien M. Giele, Sue C. Laing, Lisa Bastian, Andrew W. Burry, Kurt J. Sales, Donna B. Mak In July 2010, the Western Australia (WA) AIDS Council established the &#x2018;M Clinic&#x2019;, a peer-led STI testing service for men who have sex with men (MSM). Since the M Clinic commenced operation the number and proportion of MSM HIV notifications that were newly acquired in WA significantly increased with the peer-led clinic diagnosing 30% (n&#x00A0;=&#x00A0;21) of all newly acquired HIV among MSM in WA in the 2011&#x2013;2013 period. A peer-led approach to HIV testing should be considered in order to achieve early diagnosis and treatment of HIV among MSM. (Source: Sexual Health)
Antiretroviral Pre-Exposure Prophylaxis Does Not Enhance Immune Responses to HIV in Exposed but Uninfected Persons
Conclusions.&nbsp;We found no evidence to support the hypothesis that PrEP alters either the frequency or magnitude of HIV-specific immune responses in HIV-1&ndash;exposed seronegative individuals. These results suggest that PrEP is unlikely to serve as an immunologic prime to aid protection by a putative HIV vaccine. (Source: The Journal of Infectious Diseases)
Involvement of Nitric Oxide in the Mitochondrial Action of Efavirenz: A Differential Effect on Neurons and Glial Cells
The anti-human immunodeficiency virus (HIV) drug efavirenz (EFV) alters mitochondrial function in cultured neurons and glial cells. Nitric oxide (NO) is a mediator of mitochondrial dysfunction associated with HIV central nervous system symptoms. We show that EFV promotes inducible nitric oxide synthase (iNOS) expression in cultured glial cells and generated NO undermines their mitochondrial function, as inhibition of NOS partially reverses this effect. EFV inhibits mitochondrial Complex I in both neurons and glia; however, when the latter cells are treated for longer periods, other mitochondrial complexes are also affected in accordance with the increased NO production. These findings shed light on the mechanisms responsible for the frequent EFV-associated neurotoxicity. (Source: The Journ...
HIV infection Worsens Age-Associated Defects in Antibody Responses to Influenza Vaccine
Conclusions.&nbsp;Immune activation associated with HIV infection and impaired pTfh function heighten deficiencies in antibody responses to influenza vaccine in older individuals. Strategies to reduce immune activation or augment pTfh function may enhance antibody responses in the aging HIV-infected population. (Source: The Journal of Infectious Diseases)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Comparison of the Immunogenicity of Various Booster Doses of Inactivated Polio Vaccine Delivered Intradermally Versus Intramuscularly to HIV-Infected Adults
Conclusions.&nbsp;A 60% reduction in the standard IPV dose without reduction in antibody titers is possible through intradermal administration. (Source: The Journal of Infectious Diseases)
Comparison of the Metabolic Effects of Ritonavir-Boosted Darunavir or Atazanavir Versus Raltegravir, and the Impact of Ritonavir Plasma Exposure: ACTG 5257
Conclusions.&nbsp;Raltegravir produced the most favorable lipid profile. Metabolic syndrome rates were high at baseline and increased to the same degree in all arms. Ritonavir C24 was not different in the PI arms and had no relationship with the modest but comparable increases in lipids observed with either atazanavir or darunavir. The long-term clinical significance of the lipid changes noted with the PIs relative to raltegravir deserves further evaluation. Clinical Trials Registration.&nbsp;NCT 00811954. (Source: Clinical Infectious Diseases)
Weight Change After Antiretroviral Therapy and Mortality
Conclusions.&nbsp;The survival benefits of weight gain after ART initiation are dependent on starting BMI. Weight gain after ART is associated with lower mortality for those who are not initially overweight. (Source: Clinical Infectious Diseases)
Combined Effect of CYP2B6 and NAT2 Genotype on Plasma Efavirenz Exposure During Rifampin-based Antituberculosis Therapy in the STRIDE Study
In STRIDE, slow metabolizer CYP2B6 and NAT2 genotypes were each associated with increased plasma efavirenz concentrations during antituberculosis therapy. Concentrations were greater on therapy than off therapy in 58% with CYP2B6 and 93% with NAT2 slow metabolizer genotypes. Individuals with slow metabolizer genotypes in both genes had markedly elevated concentrations. (Source: Clinical Infectious Diseases)
Stroke and the noncommunicable diseases: A global burden in need of global advocacy
Catalyzed by advocacy in the early period of the global AIDS crisis, the past decades have witnessed a revolution in global health funding, programs, and outcomes. In 2011, global HIV/AIDS programs received $7.7 billion of development assistance, amounting to 25% of total global health funding. In comparison, all noncommunicable diseases (NCDs) combined received only $377 million or 1.2% of global health funding, 20-fold less than HIV/AIDS funding.1 Taken together, NCDs cause an estimated 66% of yearly global mortality.2 The percentage of estimated total global mortality due to stroke (11.3%), a single NCD, exceeds that of HIV/AIDS, tuberculosis, and malaria combined (7.2%) by more than 50%.2 Even limiting the percentage of the total global burden of mortality due to stroke only to that in...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Disease progression of HIV-1 infection in symptomatic and asymptomatic seroconverters in Osaka, Japan: a retrospective observational study.
CONCLUSIONS: Symptomatic seroconversion was associated with early disease progression. Furthermore, the estimated median interval until the CD4 count was &lt;350 cells/microL was only 2.9 years even in patients with asymptomatic seroconversion. These results suggest the importance of early diagnosis in early seroconverters. PMID: 26000028 [PubMed] (Source: AIDS Research and Therapy)
HIV Susceptibility Among Migrant Miners in Chokwe: A Case Study.
This article examines the association between risky sexual behavior and HIV risk perception among miners. A cross-sectional survey (n?=?293) was conducted with miners who worked in South African mines and lived in the Chokwe district of Gaza Province in southern Mozambique. The study used ordinary logistic and cumulative logistic models to understand what drives miners to HIV susceptibility. The study revealed that most miners were at risk of HIV infection as a result of risky sexual behavior. However, there was a strong negative association between risky sexual behavior and HIV risk perception. Seventy percent of the miners practicing risky sexual behavior reported low HIV risk perception. This demonstrates that miners tend to underestimate their HIV risk, which makes them more suscep...
Evaluating the risk of mixtures in the indoor air of primary school classrooms.
Authors: Mishra N, Ayoko GA, Salthammer T, Morawska L Abstract In school environments, children are constantly exposed to mixtures of airborne substances, derived from a variety of sources, both in the classroom and in the school surroundings. It is important to evaluate the hazardous properties of these mixtures, in order to conduct risk assessments of their impact on children's health. Within this context, through the application of a maximum cumulative ratio approach, this study aimed to explore whether health risks due to indoor air mixtures are driven by a single substance or are due to cumulative exposure to various substances. This methodology requires knowledge of the concentration of substances in the air mixture, together with a health-related weighting factor (i.e. refer...
Workplace-based assessment: a review of user perceptions and strategies to address the identified shortcomings
Abstract Workplace based assessments (WBAs) are now commonplace in postgraduate medical training. User acceptability and engagement is essential to the success of any medical education innovation. To this end, possessing an insight into trainee and trainer perceptions towards WBAs will help identify the major problems, permitting strategies to be introduced to improve WBA implementation. A review of literature was performed to identify studies examining trainee and trainer perceptions towards WBAs. Studies were excluded if non-English or sampling a non-medical/dental population. The identified literature was synthesised for the purpose of this critical narrative review. It is clear that there is widespread negativity towards WBAs in the workplace. This has negatively impacted on t...
Predictors of HIV/AIDS Related Ocular Manifestations among HIV/AIDS Patients in Felege Hiwot Referral Hospital, Northwest Ethiopia.
Conclusion. In this study, a higher proportion of ocular manifestations were detected in HIV/AIDS patients. Visual acuity and CD4 counts were the independent predictors of ocular manifestations. This finding gives an insight for policy makers and concerned body to integrate ophthalmic examination in ART clinics to improve the health condition of HIV/ADIS patients. PMID: 26000175 [PubMed] (Source: Journal of Ophthalmology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
When Kenyan Children?s Lives Hang on a Drip
Prof Grace Irimu shows IPS a drip feed bag and a copy of Kenya?s ?Basic Paediatric Protocols? as she explains the importance of intravenous treatment in saving the lives of young children affected by acute watery diarrhoea. Credit: Miriam Gathigah/IPSBy Miriam GathigahNAIROBI, May 23 2015 (IPS)Acute watery diarrhoea is a major killer of young children but misunderstanding over the benefits of fluid treatment is preventing many Kenyan parents from resorting to this life-saving technique and threatening to reverse the strides that the country has made in child health.The 2014 Kenya Demographic and Health Survey, released in April this year, reports that the country?s under-five mortality rate fell to 52 deaths per 1,000 live births in 2014, down from the 74 deaths in 2008-09, but sti...
Second generation physical and linkage maps of yellowtail (Seriola quinqueradiata) and comparison of synteny with four model fish
Conclusions: The second generation linkage and physical maps were constructed using 6,025 contigs having SNP markers. These maps will aid the de novo assembly of sequencing reads, linkage studies and the identification of candidate genes related to important traits. The comparison of marker contigs in the radiation hybrid map indicated that yellowtail is evolutionarily closer to medaka than to green-spotted pufferfish, three-spined stickleback or zebrafish. The synteny analysis may aid studies of chromosomal evolution in yellowtail compared with model fish. (Source: BioMed Central)
EMA Panel Recommends Evotaz for Adults With HIV-1EMA Panel Recommends Evotaz for Adults With HIV-1
An EMA panel has recommended marketing authorization for atazanavir/cobicistat for the treatment of adults with HIV-1 infection and no known mutations associated with atazanavir resistance. International Approvals (Source: Medscape Hiv-Aids Headlines)
ICYMI: Quantifying The Dad Bod And Why We Need More Black Doctors
ICYMI Health features what we're reading this week. This week, we found ourselves drawn to stories about sexual politics in health. We were blown away by our colleagues Carina Kolodny and Amber Genuske's year-long project exploring the history and power of the clitoris. We also read up on an insurance company that said it would stop covering preventative HIV drugs to its peril, and about the retraction of a study that was published in the journal Science last year, claiming that gay canvassers were able to change voters' minds about gay marriage after only 22 minutes of conversation. Read on and tell us in the comments: What did you read, listen to, watch and love this week? 1. The Overdue, Under-Told Story Of The Clitoris -- The Huffington Post In an effort to dispel "widespread ilc...
Rush to judgment: the STI-treatment trials and HIV in sub-Saharan Africa.
CONCLUSIONS: Shortcomings in published RCTs render invalid the conclusion that treating STIs and other cofactor infections is ineffective in HIV prevention. Meta-analyses of observational studies conclude that STIs can raise HIV transmission efficiency two- to fourfold. Health policy is always implemented under uncertainty. Given the known benefits of STI control, the irreparable harm from not treating STIs and the likely decline in HIV incidence resulting from STI control, it is appropriate to expand STI control programmes and to use funds earmarked for HIV prevention to finance those programmes. PMID: 25990095 [PubMed - in process] (Source: Journal of the International AIDS Society)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Global funding dips by 90 per cent, may cripple war on AIDS
Many organizations, mainly bilateral and philanthropic donors, have shifted focus to other diseases such as tuberculosis and family planning, sources said. (Source: The Economic Times)
FDA, FTC asked to stop Coca-Cola, Pepsi from falsely advertising unhealthy "diet" soda
(NaturalNews) How is it that a product that can make people gain weight is allowed to be labeled as "diet"? Doesn't that word imply that it aids in shedding pounds and is something that those hoping to lose or maintain weight should gravitate towards?Coca-Cola Co. and PepsiCo... (Source: NaturalNews.com)
Learning about Cognition Risk with the Radial-Arm Maze in the Developmental Neurotoxicology Battery
Publication date: Available online 23 May 2015 Source:Neurotoxicology and Teratology Author(s): Edward D. Levin Cognitive dysfunction has been found in epidemiological studies to be among the most sensitive impairments associated with developmental exposure to a variety of environmental contaminants from heavy metals to polyhalogenated hydrocarbons and pesticides. These chemicals have been also shown to impair cognitive function after developmental exposure in experimental animal models. The radial-arm maze (RAM) has proven to be a sensitive and reliable way to assess both learning and memory in a variety of species, most often in rats and mice. The RAM is a very adaptable test method that takes advantage of rodents? instinct to explore new places in the environment to forage. That is,...
Multicomponent systems with cyclodextrins and hydrophilic polymers for the delivery of Efavirenz
Publication date: 5 October 2015 Source:Carbohydrate Polymers, Volume 130 Author(s): Alexandre Couto Carneiro Vieira , Danilo Augusto Ferreira Fontes , Luise Lopes Chaves , Lariza Darlene Santos Alves , José Lourenço de Freitas Neto , Monica Felts de La Roca Soares , Jose L. Soares-Sobrinho , Larissa Araújo Rolim , Pedro José Rolim-Neto Efavirenz (EFZ) is one of the most used drugs in the treatment of AIDS and is the first antiretroviral choice. However, since it has low solubility, it does not exhibit suitable bioavailability, which interferes with its therapeutic action and is classified as a class II drug according Biopharmaceutical Classification System (low solubility and high permeability). Among several drug delivery systems, the multicomponent systems with cyclodextrins and h...
Hippocampal sharp-wave ripples in waking and sleeping states.
Authors: Roumis DK, Frank LM Abstract Waking and sleeping states are privileged periods for distinct mnemonic processes. In waking behavior, rapid retrieval of previous experience aids memory-guided decision making. In sleep, a gradual series of reactivated associations supports consolidation of episodes into memory networks. Synchronized bursts of hippocampal place cells during events called sharp-wave ripples communicate associated neural patterns across distributed circuits in both waking and sleeping states. Differences between sleep and awake sharp-wave ripples, and in particular the accuracy of recapitulated experience, highlight their state-dependent roles in memory processes. PMID: 26011627 [PubMed - as supplied by publisher] (Source: Current Opinion in Neurobiology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
The Importance of Finding Your Tribe (VIDEO)
I'm From Driftwood is a 501(c)(3) nonprofit archive for lesbian, gay, bisexual, transgender, and queer stories. New stories are posted on the site every Wednesday. Throughout Robert Scott's life, he had an alcoholic father, became overweight and addicted to drugs, and was affected by the AIDS crisis in San Francisco in the 1980s. Reflecting on his life, he realizes one thing: the importance of finding one's tribe. Robert recalls: I went from academic, grad school, Ph.D. candidate to a hippy living on a commune to a fat gay man coming to San Francisco, losing 130 pounds, finding tribes at every juncture. The only tribe that's actually stuck for me at this juncture in my life is the tribe that I found in recovery. I'm still friends with those people, and it's 40 years later. After watchi...
Nigeria: HIV Positive Robber Infects Women
[Daily Trust] Kaduna -Police sources told Daily Trust in Kaduna yesterday that a HIV-positive member of a robbery gang recently smashed by detectives from the command confessed to have befriended a number of women and deliberately raped some, to infect them with the virus. (Source: AllAfrica News: HIV-Aids and STDs)
'I want nothing more than to hear my children': Emotional video captures the incredible moment three deaf people hear the voices of their families and friends
A new video captures the incredible moment that the men and women who live in Puerto Princesa, one of the poorest areas in the Philippines, are made able to hear sounds after being fitted with hearing aids. (Source: the Mail online | Health)
Botswana: PAC Member Against Patients Segregation
[Botswana Daily News] Gaborone -A member of Public Accounts Committee (PAC) says government needs to act promptly but cautiously towards addressing the seemingly disturbing scenario of segregating ARV drugs recipients from the rest of other outpatient drug dispensing units. (Source: AllAfrica News: HIV-Aids and STDs)
Tanzania: Aids Deaths Seen Coming Down
[Daily News] THE number of deaths that have resulted from AIDS has gone down by 40 per cent while the prevalence of infections has decreased by 50 per cent for the past ten years, following various initiatives carried out by Tanzania Commission for AIDS (TACAIDS) and other stakeholders. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Intestinal Microsporidiosis
Infection by the ingested pathogens of microsporidia occur primarily in immunosuppressed patients (including untreated HIV/AIDS) and are diagnosed by stool examination, small bowel biopsy with special stains, or electron microscopy (for definitive speciation), or by various molecular techniques. Although electron microscopy has been the definitive diagnostic tool for speciation, genetic sequencing increasingly provides the definitive diagnosis for new species, such as Anncaliia algerae. Further genetic sequencing of the common pathogens may allow for the development of advanced molecular diagnostics providing high diagnostic sensitivity and throughput. (Source: Clinics in Laboratory Medicine)
Implementing Implementation Science: An Approach for HIV Prevention, Care and Treatment Programs.
Authors: Lambdin BH, Cheng B, Peter T, Mbwambo J, Apollo T, Dunbar M, Udoh IC, Cattamanchi A, Geng EH, Volberding P Abstract Though great progress has been realized over the last decade in extending HIV prevention, care and treatment in some of the least resourced settings of the world, a substantial gap remains between what we know works and what we are actually achieving in HIV programs. To address this, leaders have called for the adoption of an implementation science framework to improve the efficiency and effectiveness of HIV programs. Implementation science (IS) is a multidisciplinary scientific field that seeks generalizable knowledge about the magnitude of, determinants of and strategies to close the gap between evidence and routine practice for health in real-world setting...
Phosphorylation?dependent and Phosphorylation?independent Regulation of Helicobacter pylori Acid Acclimation by the ArsRS Two?component System
ConclusionsArsRS has a dual function in acid acclimation: regulation of urease trafficking to UreI at the cytoplasmic membrane, driven by ArsS, and regulation of urease gene cluster expression, driven by phosphorylation of ArsR. ArsS and ArsR work through phosphorylation?dependent and phosphorylation?independent regulatory mechanisms to impact acid acclimation and allow gastric colonization. Furthering understanding of the intricacies of acid acclimation will impact the future development of targeted, nonantibiotic treatment regimens. (Source: Helicobacter)
Disease progression of HIV-1 infection in symptomatic and asymptomatic seroconverters in Osaka, Japan: a retrospective observational study
We examined the interval until disease progression in HIV-1 seroconverters in whom the timing of infection could be estimated within 1 year before diagnosis. Methods: Subjects included newly diagnosed patients at Osaka National Hospital between 2003 and 2010 who had either (1) symptomatic acute HIV-1 infection with a negative or intermediate reaction on Western blotting and a positive reaction on an HIV RNA test (symptomatic acute group) or (2) a positive reaction on Western blotting at diagnosis and a (Source: AIDS Research and Therapy)
National Library of Medicine Announces Solicitation of Quotations for the 2015 HIV/AIDS Community Information Outreach Projects
The National Library of Medicine (NLM) is pleased to announce the solicitation of quotations from organizations and libraries to design and conduct projects for improving HIV/AIDS information access for patients and the affected community as well as their caregivers and the general public. Patients and the affected community need access to the most up-to-date and accurate health information to effectively manage and make informed decisions about their health. Health care providers and health educators also need access to the most current information to provide the highest quality of care. NLM is committed to assisting organizations in accessing the spectrum of information resources and services that are currently available. The NLM is particularly interested in proposals with creative and ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Recent HIV/AIDS News from FDA, NIAID, and NIH
News from FDA May 12, 2015: Draft Blood Donor Deferral Policy for Men Who Have Had Sex With Another Man (MSM) News from NIAID May 19, 2015: HIV Reservoirs Remain Obstacles to Cure May 18, 2015: HIV Vaccine Awareness Day 2015 May 13, 2015: NYVAC-HIV Vaccine Used in the HVTN 092 and HVTN 096 Clinical Trials News from NIH May 18, 2015: Dr. Robert W. Eisinger to Serve as Acting Associate Director for AIDS Research, NIH (Source: AIDSinfo At-a-Glance: Offering Information on HIV/AIDS Treatment, Prevention, and Research, A Service of the U.S. Department of Health and Human Services (DHHS))
Blue Marble Health and ?The Big Three Diseases?: HIV/AIDS, Tuberculosis, and Malaria
Publication date: Available online 21 May 2015 Source:Microbes and Infection Author(s): Peter J. Hotez (Source: Microbes and Infection)
Interrater Agreement Between Visual Analysts of Single-Case Data: A Meta-Analysis
Visual analysis is the most widely applied method of data interpretation for single-case research as it encompasses multifaceted considerations relevant to evaluating behavior change. However, a previous research synthesis found low levels of interrater agreement between visually analyzed ratings of graphed data across all variables under analysis. The purpose of this meta-analysis was to evaluate the peer-reviewed literature to date for potential moderators affecting the proportion of interrater agreement between visual analysts. Nineteen articles with 32 effects were assembled. Potential moderators evaluated included (a) design families, (b) rater expertise, (c) the provision of contextual information for graphs, (d) the use of visual aids, (e) the provision of an operational definition ...
Bronchopulmonary Kaposi's sarcoma
We describe a case of Bronchopulmonary Kaposi's sarcoma in a patient with AIDS who was successfully treated with HAART and Liposomal Doxorubicin chemotherapy. (Source: Respiratory Medicine Case Reports)
Outcomes of antiretroviral treatment in HIV-infected adults: a dynamic and observational cohort study in Shenzhen, China, 2003-2014
Conclusions Sustained virological and immunological outcomes show that patients have responded positively to long-term antiretroviral treatment with low mortality. This 10-year data study provides important information for clinicians and policymakers in the region as they begin to evaluate and plan for the future needs of their own rapidly expanding programmes. (Source: BMJ Open)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Acetic acid enhances endurance capacity of exercise-trained mice by increasing skeletal muscle oxidative properties.
In this study, we investigated the effects of acetic acid on endurance capacity and muscle oxidative metabolism in the exercise training using in vivo mice model. In exercised mice, acetic acid induced a significant increase in endurance capacity accompanying a reduction in visceral adipose depots. Serum levels of non-esterified fatty acid and urea nitrogen were significantly lower in acetic acid-fed mice in the exercised mice. Importantly, in the mice, acetic acid significantly increased the muscle expression of key enzymes involved in fatty acid oxidation and glycolytic-to-oxidative fiber-type transformation. Taken together, these findings suggest that acetic acid improves endurance exercise capacity by promoting muscle oxidative properties, in part through the AMPK-mediated fatty acid o...
Red Nose Charity Celeb Supporters Include Kim Kardashian, Reese Witherspoon
The carpet won't be the only thing red at the Hammerstein Ballroom Thursday night. Dozens of Hollywood are supporting Red Nose Day -- a three-hour televised event held at the New York City venue raising awareness and funds for several nonprofits, including Feeding America, Save the Children and the United Way. Although the show will raise money through a telethon, the NBC broadcast will be "very, very, very different" from the conventional method of fundraising, event creator and film writer-director Richard Curtis told The Associated Press. The event -- which has raised more than 78 million British pounds, or about $122 million, in the U.K. since its inception in 1988, according to CNN -- will incorporate both live and pre-recorded segments. Funds donated toward past events have bene...
[In Depth] Canadian registry to track thousands of pot smokers
Fifteen years after learning about the medical benefits of cannabis from patients in a sickle cell clinic in Kingston, Mark Ware is studying the drug on a grand scale. A pain management researcher at McGill University Health Centre in Montreal, Canada, he directs the Quebec Cannabis Registry, a new, one-of-a-kind database that aims to gather information on every patient prescribed marijuana in the province over the next 10 years?an estimated 3000 in all. By collecting data on symptoms, dosage, improvement, and side effects, the registry, launched on 11 May and funded by a grant from the nonprofit Canadian Consortium for the Investigation of Cannabinoids, aims to fill gaps in knowledge about the efficacy and safety of medical marijuana. Even as more and more states and countries legalize ...
Arhp: hiv/aids
Resources for improving HIV/AIDS prevention and patient care. (Source: PHPartners.org)
Zimbabwe: Zimbabwe Has Highest Condom Usage in the World
[News24Wire] Zimbabwe has the highest condom usage in the world and this has contributed to a reduction in HIV infections, the state-run National Aids Council (NAC) has revealed. (Source: AllAfrica News: Health and Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Zimbabwe: Zimbabwe Has 'Highest Condom Usage in World'
[News24Wire] Zimbabwe has the highest condom usage in the world and this has contributed to a reduction in HIV infections, the state-run National Aids Council (NAC) has revealed. (Source: AllAfrica News: Health and Medicine)
Zimbabwe: Informal Sector to Pay Aids Levy
[Financial Gazette] The majority of those in the informal sector are involved in survivalist ventures with evidence showing that 40 percent of them earn less than US$200 per month while 11 percent do not have a monthly income. (Source: AllAfrica News: HIV-Aids and STDs)
Cleric uses video to tell congregation she has HIV
Watch this heartwarming video of a pastor who uses a series of cardboard messages to tell her congregation that she is HIV positive (Source: Telegraph Health)
Namibia: Dancers Need Sponsors for Ovcs' Fundraiser
[New Era] Tov HIV and AIDS Orphans & Vulnerable Children Organisation will host a Non-stop Dancing Event next Saturday, May 30, at the Tov Multi Purpose Centre in Tsumeb. (Source: AllAfrica News: HIV-Aids and STDs)
Malawi: Commercial Sex Workers Who Were Forced for HIV Test Win Case in Court
[Malawi24] The High Court of Malawi has today ruled that subjecting people to mandatory HIV Test is a violation of fundamental human rights such the right to equality and non-discrimination, right to dignity and right not to be subjected to cruel, inhuman and degrading treatment. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Zimbabwe: HIV On the Prowl in Mining Towns
[The Herald] In the heart of Mashonaland Central province lies Shamva town, a hub of mining activities approximately 90km north-east of Harare. (Source: AllAfrica News: HIV-Aids and STDs)
Evaluation of 2 Novel Devices for Calculation of Fluid Requirements in Pediatric Burns
Conclusions: Both novel devices provide safer and faster alternatives to conventional methods for calculation of fluid requirements in pediatric burns. (Source: Annals of Plastic Surgery)
Burns in sub-Saharan Africa: A review
Conclusions These statistics indicate the need for an urgent review of burn policies and related legislation across the sub-Saharan region to help reduce burns, and provide a safe environment for children. (Source: Burns)
Overdose of dolutegravir in combination with tenofovir disaproxil fumarate/emtricitabine in suicide attempt in a 21-year old patient
A 21 year old MSM patient with newly diagnosed HIV infection was hospitalized in our department after ingestion of an overdose of his antiretroviral therapy (ART) comprising dolutegravir (DTG - Tivicay®) and tenofovir disaproxil fumarate/emtricitabine (Truvada®) in suicidal intention. On admission, the patient did not show any clinical signs of intoxication and laboratory findings were unremarkable. After 6 hours of intensive care monitoring, the patient was referred to a psychiatric clinic. 5 days after the day of intoxication, serum creatinine levels increased to high normal values (1.2 mg/dl). However, levels never exceeded the upper threshold. 8 and 12 weeks later, serum creatinine normalized to levels measured prior to the intoxication. No other adverse events occurred, and the...
The role of conspicuity in preventing bicycle crashes involving a motor vehicle
Conclusion: Conspicuity aids may not be effective in preventing bicycle&ndash;motor vehicle crashes in New Zealand, particularly in Auckland, where attention conspicuity is low. (Source: The European Journal of Public Health)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Erratum to: Sexual Mixing in Shanghai: Are Heterosexual Contact Patterns Compatible With an HIV/AIDS Epidemic?
(Source: Demography)
Novelty's effect on memory encoding.
Authors: Rangel-Gomez M, Janenaite S, Meeter M Abstract It is often thought that novelty benefits memory formation. However, support for this idea mostly comes from paradigms that are open to alternative explanations. In the present study we manipulated novelty in a word-learning task through task-irrelevant background images. These background images were either standard (presented repeatedly), or novel (presented only once). Two types of background images were used: Landscape pictures and fractals. EEG was also recorded during encoding. Contrary to the idea that novelty aids memory formation, memory performance was not affected by the novelty of the background. In the evoked response potentials, we found evidence of distracting effects of novelty: both the N1 and P3b components we...
Lifetime suicide attempt history, quality of life, and objective functioning among HIV/AIDS patients with alcohol and illicit substance use disorders - Walter KN, Petry NM.
This cross-sectional study evaluated lifetime prevalence of suicide attempts in 170 HIV/AIDS patients with substance use disorders and the impact of suicide attempt history on subjective indices of quality of life and objective indices of cognitive and phy... (Source: SafetyLit: All (Unduplicated))
Africa: UN Agency Calls for Renewed Global Commitment to Develop Effective HIV Vaccine
[UN News] To mark HIV Vaccine Awareness Day, the Joint United Nations Programme on HIV/AIDS, or UNAIDS, has renewed its call for a sustained worldwide commitment to finding an effective HIV vaccine. (Source: AllAfrica News: Health and Medicine)
Work Productivity Loss Is Highest in U.S. Workers with AIDS, Broken...
New results from the National Health and Wellness Survey show that although overall impairment is 15 percent for the U.S. workforce, impairment for people with AIDS or broken bones tops 40 percent.(PRWeb May 19, 2015)Read the full story at http://www.prweb.com/releases/2015/05/prweb12724595.htm (Source: PRWeb: Medical Pharmaceuticals)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Screening and Treatment to Prevent Cryptococcal MeningitisScreening and Treatment to Prevent Cryptococcal Meningitis
Does cryptococcal antigen screening and testing have an impact on preventing cryptococcal meningitis in people with AIDS? JAIDS: Journal of Acquired Immune Deficiency Syndromes (Source: Medscape Today Headlines)
Increased systemic immune activation and inflammatory profile of long-term HIV-infected ART-controlled patients is related to personal factors, but not to markers of HIV infection severity
Conclusions In these long-term treatment-controlled HIV-infected patients, all systemic markers of inflammation and immune activation were increased compared with healthy controls. This was related to demographic and behavioural factors, but not to markers of severity of the HIV infection. Intervention to decrease low-grade inflammation must thus prioritize modifiable personal factors. (Source: Journal of Antimicrobial Chemotherapy)
Low HIV-1 transmitted drug resistance in Bulgaria against a background of high clade diversity
Conclusions We found a low prevalence of TDR against a background of high HIV-1 genetic diversity among antiretroviral-naive patients in Bulgaria. Our results provide baseline data on TDR and support continued surveillance of high-risk populations in Bulgaria to better target treatment and prevention efforts. (Source: Journal of Antimicrobial Chemotherapy)
Knowledge, attitudes and practices on HIV/AIDS and prevalence of HIV in the general population of Sucre, Bolivia
Conclusions Prevalence of HIV infection is very low and unsafe sex is relatively uncommon. Inadequate knowledge on HIV/AIDS and discriminatory attitudes towards PLWHA are extremely high and are associated to gender, ethnic and economic inequalities. (Source: The Brazilian Journal of Infectious Diseases)
CCR5 ?32 homozygous cord blood allogeneic transplantation in a patient with HIV: a case report
We present a 37-year-old patient with HIV-1 infection and aggressive lymphoma who had disease progression after five lines of radiochemotherapy including an autologous HCT, and in the absence of matched sibling donors, received an allogeneic HCT with four of six HLA-matched CCR5 ?32 homozygous cord blood cells (StemCyte, Covina, CA), supported with purified CD34+ cells from a haploidentical sibling. Blood or tissue samples were obtained before and weekly after HCT to monitor transplant and HIV infection, including chimerism analysis, CCR5 genotyping and viral tropism, viral isolation and sequence, viral reservoir analysis, immune activation and proliferation, and ex-vivo cell infectivity assays. Combined antiretroviral therapy continued during the procedure. Findings The patient's HIV wa...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Efavirenz treatment causes arterial stiffening in apolipoprotein E-null mice
The development of highly active antiretroviral therapy (HAART) has transformed HIV-1 infection from a terminal diagnosis to a chronic, yet manageable disease. However, people living with HIV-1 exhibit a host of non-AIDS-related co-morbidities including cardiovascular disease (CVD). Several HAART drugs have been implicated in the development of CVD; however, the role of efavirenz (EFV), a highly prescribed HAART drug, in early-onset CVD is poorly understood. We treated apolipoprotein E-null (ApoE-/-) mice with EFV (75mg/kg/day) or vehicle, via oral gavage, for 35 days and quantified commonly measured preclinical markers of CVD (intima-media thickening, arterial stiffening) and plaque area. (Source: Journal of Biomechanics)
Measurement of plant growth in view of an integrative analysis of regulatory networks.
Authors: Wuyts N, Dhondt S, Inzé D Abstract As the regulatory networks of growth at the cellular level are elucidated at a fast pace, their complexity is not reduced; on the contrary, the tissue, organ and even whole-plant level affect cell proliferation and expansion by means of development-induced and environment-induced signaling events in growth regulatory processes. Measurement of growth across different levels aids in gaining a mechanistic understanding of growth, and in defining the spatial and temporal resolution of sampling strategies for molecular analyses in the model Arabidopsis thaliana and increasingly also in crop species. The latter claim their place at the forefront of plant research, since global issues and future needs drive the translation from laboratory model...
HIV/AIDS Among American Indians and Alaska Natives in the United States
Describes how HIV infection affects American Indians and Alaska Natives (AI/AN) and why it is a serious public health issue among AI/AN. Compares survival rates of infected AI/AN with other races/ethnicities. (Source: Rural publications via the Rural Assistance Center)
UN agency calls for renewed global commitment to develop effective HIV vaccine
To mark HIV Vaccine Awareness Day, the Joint United Nations Programme on HIV/AIDS, or UNAIDS, has renewed its call for a sustained worldwide commitment to finding an effective HIV vaccine. (Source: UN News Centre - Health, Poverty, Food Security)
Africa: From Africa, With One Voice
[GFO] As the continent receiving the lion's share of Global Fund investments in the fight against AIDS, TB and malaria, Africa must do more to ensure its voices are heard in decision-making and strategy development: this was the clarion call made in Addis Ababa on 5 May at the first official meeting of the Africa Bureau. (Source: AllAfrica News: Health and Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Kenya: Farming Promotes Health and Wealth of HIV - Aids Patients in Naivasha
[The Star] Long stimatised by the community, HIV positive patients in Naivasha have become more confident and are now some of the leading crop and dairy farmers in the region, thanks to a programme on poverty eradication run by the Catholic Church under the Assumption Sisters of Nairobi. (Source: AllAfrica News: Health and Medicine)
Nigeria: HIV/Aids Blamed for 59.3 Percent Female Deaths in Four Yrs - Report
[Daily Trust] HIV/AIDS accounted for 59.3 percent of female deaths recorded in Nigeria for four years on the average according to figures released by the National Bureau of Statistics (NBS). (Source: AllAfrica News: HIV-Aids and STDs)
Twitter could provide valuable details about transgender people?s health needs, UCLA-led study finds
Transgender and gender-nonconforming people have a higher-than-average risk for AIDS and are more vulnerable than others to depression. But because stigma about gender identities makes them less likely to disclose information about themselves to researchers, it also has been difficult for doctors to understand the best ways to provide care for them. New research by the University of California Institute for Prediction Technology suggests that social media could help fill that knowledge gap. In a study published in the peer-reviewed journal JMIR Mental Health, the researchers reported that because transgender and gender-nonconforming people frequently use social media to discuss important health and social needs, resources like Twitter may provide a wealth of useful information for docto...
Stability and survival of bone-anchored hearing aid implant systems in post-irradiated patients
Abstract Bone-anchored hearing aids (BAHAs) are based on the principle of osseointegration, which is fundamental to implant stability and survival. Previous exposure to ionising radiation may compromise this, as evidenced in relation to dental and craniofacial implants. There is a dearth of data, however, regarding BAHA implant systems in patients with previously irradiated implant sites. We sought, therefore, to investigate implant stability and survival in such patients. Patients were identified retrospectively from our electronic BAHA database. Hospital records were reviewed for demographics; operative technique; complications; and details regarding previous irradiation. Implant stability was assessed by resonance frequency analysis (RFA), generating a numerical value?implan...
'Redesigned' antibodies may control HIV: Vanderbilt study
(Vanderbilt University Medical Center) With the help of a computer program called 'Rosetta,' researchers at Vanderbilt University have 'redesigned' an antibody that has increased potency and can neutralize more strains of the AIDS-causing human immunodeficiency virus than can any known natural antibody. (Source: EurekAlert! - Social and Behavioral Science)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Behavioral Economics Matters for HIV Research: The Impact of Behavioral Biases on Adherence to Antiretrovirals (ARVs)
We present novel evidence on the prevalence of the common behavioral decision-making errors of present-bias, overoptimism, and information salience among 155 Ugandan HIV patients, and analyze their association with subsequent medication adherence. 36 % of study participants are classified as present-biased, 21 % as overoptimistic, and 34 % as having salient HIV information. Patients displaying present-bias were 13 % points (p = 0.006) less likely to have adherence rates above 90 %, overoptimistic clients were 9 % points (p = 0.04) less likely, and those not having salient HIV information were 17 % points (p &lt; 0.001) less likely. These findings indicate that BE may be used to screen for future adherence problems and to better design and target interventions addressing these ...
Correlates of HIV Testing Among Men Who have Sex with Men in Three Urban Areas of Mozambique: Missed Opportunities for Prevention
Abstract This is the first study to identify levels of recent HIV testing and associated factors among men who have sex with men (MSM) in Mozambique. Using data from Maputo (n = 493), Beira (n = 572), and Nampula/Nacala (n = 347), collected via respondent-driven sampling in 2011, and excluding those with prior known infection, we found that 30.4 % [95 % confidence interval (CI) 25.0?36.3 %], 42.1 % (95 % CI 36.8?47.3 %) and 29.8 % (95 % CI 22.9?36.9 %), respectively, had recently tested for HIV (?12 months), while between three and five out of 10 MSM had never tested. A range of factors was associated with recent HIV testing such as familiarity with the modes of transmission, knowledge of antiretroviral treatment for HIV, contact with peer educators and awa...
D-Ribose aids heart failure patients with preserved ejection fraction and diastolic dysfunction: a pilot study
Conclusions: This pilot study revealed some beneficial trends with D-ribose even with this small cohort size. However, future investigations are necessary to further substantiate these observed benefits. (Source: Therapeutic Advances in Cardiovascular Disease)
Integrating small molecule signalling and H?NS antagonism in Vibrio cholerae, a bacterium with two chromosomes
Abstract H?NS is a well?established silencer of virulence gene transcription in the human pathogen Vibrio cholerae. Biofilm formation aids V. cholerae in colonizing both its host and its external environments and H?NS silences biofilm gene expression. Cyclic?di?guanosine monophosphate acts through the DNA binding proteins VpsR and VpsT to overcome H?NS?mediated repression of biofilm genes, driving a transition between a planktonic and a colonial/biofilm lifestyle. The H?NS binding pattern has now been charted on both chromosomes in V. cholerae but whether or not this abundant DNA?binding?and?bridging protein plays any roles in nucleoid organization in this bacterium remains an open question. (Source: Molecular Microbiology)
Highlights from this issue
In 1970, the US Surgeon General is said to have declared that it was time to "close the book on infectious diseases, declare the war against pestilence won and shift national resources to such chronic problems as cancer and heart disease". Though this attribution has been disputed,1 the undoubted optimism of that era over infectious disease now seems a world away, after a year in which Ebola both reached and was transmitted within the United States of America. In recent years we have been alarmed by the re-emergence of ancient diseases in newly resistant form&mdash;particularly gonorrhoea and tuberculosis. This month, Tuddenham and Ghanem's editorial introduces a mini-series on the threat of antimicrobial resistant (AMR) gonorrhoea,2 featuring expert analyses by international experts Rice,...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Spotting the Signs: a national toolkit to help identify young people at risk of child sexual exploitation
It has been widely reported in research and inquiries that child sexual exploitation (CSE) is both under-reported and unrecognised by statutory and voluntary sector organisations.1&ndash;3 A report by the Office of the Children's Commissioner found that at least 16&nbsp;500 children were identified as being at risk of CSE each year by gangs and groups.1 Between 5% and 17% of children under 16 (between 650&nbsp;000 and 2 million children) experience sexual abuse, and more than one in three do not tell anyone during childhood.2 CSE has been defined by the National Working Group for Sexually Exploited Children and Young People3 as the involvement of those aged &lt;18 in exploitative situations, contexts and relationships where the young people (or a third person) receive something (eg, affect...
Delaying the widespread emergence of cephalosporin-resistant gonorrhoea: what is the best target?
Neisseria gonorrhoeae is associated with high morbidity worldwide. The emergence of cephalosporin and macrolide resistance represents a grave threat to the control of a disease, which, if untreated, can lead to serious reproductive complications in women, blindness in neonates, facilitated spread of HIV and, in rare cases, life-threatening disseminated infections.1 2 A plenary was convened at the Centers for Disease Control and Prevention's (CDC) sexually transmitted disease (STD) Prevention Conference held in Atlanta, Georgia, 9&ndash;12 June 2014, to discuss several key aspects pertaining to this issue. The Scientific Committee, including Drs Matthew Golden from the University of Washington, Kevin Karem from CDC and Khalil Ghanem from Johns Hopkins University School of Medicine, invited ...
Will targeting oropharyngeal gonorrhoea delay the further emergence of drug-resistant Neisseria gonorrhoeae strains?
Gonorrhoea is an important sexually transmitted infection associated with serious complications and enhanced HIV transmission. Oropharyngeal infections are often asymptomatic and will only be detected by screening. Gonococcal culture has low sensitivity (&lt;50%) for detecting oropharyngeal gonorrhoea, and, although not yet approved commercially, nucleic acid amplification tests (NAAT) are the assay of choice. Screening for oropharyngeal gonorrhoea should be performed in high-risk populations, such as men-who-have-sex-with-men(MSM). NAATs have a poor positive predictive value when used in low-prevalence populations. Gonococci have repeatedly thwarted gonorrhoea control efforts since the first antimicrobial agents were introduced. The oropharyngeal niche provides an enabling environment for...
Imiquimod 5% cream for five consecutive days a week in an HIV-infected observational cohort up to 32 weeks in the treatment of high-grade squamous intraepithelial lesions
Conclusions Topical imiquimod 5% cream is useful in HSIL. A five consecutive days treatment regimen with imiquimod 5% cream for HSIL does not seem to be more effective compared with the customary prescription for 3&nbsp;days a week. A prolonged course of imiquimod 5% cream is warranted for intra-anal HSIL. Adverse effects are comparable between 3 and 5&nbsp;days treatment regimen. (Source: Sexually Transmitted Infections)
Engaging young adult clients of community pharmacies for HIV screening in Coastal Kenya: a cross-sectional study
Conclusions About a quarter of targeted pharmacy clients took up HIV-1 testing. Clients seeking care directly at the pharmacy (ie, without a prescription) and those with STI symptoms were more likely to take up HIV-1 testing. Engagement of adult pharmacy clients for HIV-1 screening may identify undiagnosed individuals and offers opportunities for HIV-1 prevention research. (Source: Sexually Transmitted Infections)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Discordance of HIV and HSV-2 biomarkers and self-reported sexual behaviour among orphan adolescents in Western Kenya
Conclusions Our study demonstrates the discordance between infections measured by biomarkers and self-reports of having had sex among orphan adolescents in Kenya. In order to detect programme effects accurately in prevention research, it is necessary to collect both baseline and endline biological data. Furthermore, it is recommended to triangulate multiple data sources about adolescent participants&rsquo; self-reported information about marriage and pregnancies from school records and parent/guardians to verify the information. Researchers should recognise potential threats to validity in data and design surveys to consider cognitive factors and/or cultural context to obtain more accurate and reliable information from adolescents regarding HIV/sexually transmitted infection risk behaviour...
Interest in using rectal microbicides among Australian gay men is associated with perceived HIV vulnerability and engaging in condomless sex with casual partners: results from a national survey
Conclusions Interest in using rectal microbicides was associated with self-perceived vulnerability to HIV, engaging in sexual practices that increase the risk of HIV acquisition and less uncertainty about the efficacy of microbicides. There appears to be a group of men who would benefit from, and are highly motivated to use, a rectal microbicide product. (Source: Sexually Transmitted Infections)
Key factors in the acceptability of treatment as prevention (TasP) in Scotland: a qualitative study with communities affected by HIV
Conclusions Our results suggest that potential use and management of TasP may not be straightforward. It could be contingent on reducing inequalities in HIV literacy, minimising the perceived burden of treatment and other potential risks, and addressing the dynamics of existing and socially acceptable risk management strategies, especially in relation to long-term serodiscordant relationships. (Source: Sexually Transmitted Infections)
Anogenital preinvasive and invasive lesions in the Limpopo Province of South Africa
Anogenital preinvasive and invasive lesions are known to have been on the increase in the industrialised world since the 1970s.1 The increase in anal squamous cell carcinomas and Kaposi's sarcomas (KS) has often been associated with the HIV epidemic, especially among men having sex with men. KS and non-Hodgkin's lymphoma are virus-related (KS-associated herpes virus and Epstein&ndash;Barr, respectively) AIDS-defining illnesses.2 Among anogenital cancers, only cervical cancer is listed as AIDS-defining illness. A large proportion of anogenital preinvasive and invasive lesions are human papillomavirus (HPV)-related, with a variable proportion of low-grade and high-grade (HG) HPV. HPV is a necessary cause of cervical cancer.3 Vulvar carcinomas are either HPV-related or not.4 The proportion of...
Repeated STI and HIV testing among HIV-negative men who have sex with men attending a large STI clinic in Amsterdam: a longitudinal study
Conclusions The proportion of MSM testing for STI annually is low. MSM testing repeatedly had higher baseline levels of risk behaviour. Strategies to motivate MSM to test annually should be explored. (Source: Sexually Transmitted Infections)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Clinical roundup
What are the chances, doctor? The risk of HIV transmission from a single sexual encounter is a popular topic of conversation between sexual healthcare providers and patients. Patel et al have recently updated the USA&rsquo; Centers for Disease Control 2005 review, in which this risk was previously estimated.1 2 Their review includes the most recent observational and interventional study findings, in particular those pertaining to the use of treatment as prevention (TasP). The review reports that receptive anal intercourse carries a risk of 138 transmissions per 10&nbsp;000 acts (1.38%) in the absence of antiretroviral therapy (ART) or condoms, compared with 4 transmissions per 10&nbsp;000 acts of insertive penile&ndash;vaginal sex (0.04%). The use of both condoms and ART reduces the risk o...
Use of new antiretroviral drugs and classes in Bahia, Brazil: a real life experience on salvage therapy of AIDS patients
Publication date: Available online 19 May 2015 Source:The Brazilian Journal of Infectious Diseases Author(s): Carlos Brites , Isabella Nóbrega , Eduardo Martins Netto Antiretroviral therapy has significantly evolved in the last decade, with an increasing number of new drugs and classes. Currently, even heavily experienced patients can be successfully treated with new regimens. In Brazil, the recent incorporation of some new antiretroviral drugs made it possible to suppress HIV plasma viremia in most treated patients, with significant benefits in terms of quality of life and survival. However, little has been published on outcomes of patients under new drugs-based regimens. We reviewed the safety and efficacy of antiretroviral regimens using recently introduced drugs in Bahia. Our result...
Applying Qualitative Data Derived from a Rapid Assessment and Response (RAR) Approach to Develop a Community-Based HIV Prevention Program for Adolescents in Thailand
HIV education programs are needed to address risk-taking behavior for adolescents. The purpose of our study was to use the World Health Organization?s Rapid Assessment and Response (RAR) method to design a community-based, cultural- and age-appropriate HIV prevention program for adolescents in Bangkok, Thailand. Adolescent single-gender-specific focus groups (n = 3; 28 participants) were used to gather reactions/ideas about program topics/approaches. An adult, mixed-gender group was held to review information identified by adolescents. (Source: Journal of the Association of Nurses in AIDS Care)
Provider perspectives regarding the health care needs of a key population: HIV-infected prisoners after incarceration
During incarceration, many HIV-infected prisoners receive care and are adherent to medication. However, following release, many have difficulty engaging in HIV care and remaining on antiretroviral therapy (ART). Community-based service providers for HIV-infected releasees have a deep understanding of the health needs and challenges these individuals face on community re-entry. We conducted in-depth qualitative interviews with 38 health care and service professionals in 2 U.S. southern states regarding the barriers releasees faced in meeting their health needs, including HIV care and treatment post-release. (Source: Journal of the Association of Nurses in AIDS Care)
Antiretroviral Drugs in Meconium: Detection for Different Gestational Periods of Exposure
To determine whether antiretroviral (ARV) medications can be detected in meconium from second or third trimester, labor and delivery (L&D), or postnatal exposures. (Source: The Journal of Pediatrics)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
ChiNet uncovers rewired transcription subnetworks in tolerant yeast for advanced biofuels conversion
Analysis of rewired upstream subnetworks impacting downstream differential gene expression aids the delineation of evolving molecular mechanisms. Cumulative statistics based on conventional differential correlation are limited for subnetwork rewiring analysis since rewiring is not necessarily equivalent to change in correlation coefficients. Here we present a computational method ChiNet to quantify subnetwork rewiring by statistical heterogeneity that enables detection of potential genotype changes causing altered transcription regulation in evolving organisms. Given a differentially expressed downstream gene set, ChiNet backtracks a rewired upstream subnetwork from a super-network including gene interactions known to occur under various molecular contexts. We benchmarked ChiNet for its hi...
Lack of replication of four candidate SNPs implicated in human male fertility traits: a large-scale population-based study
This study indicated that none of the four SNPs rs7867029, rs12870438, rs7174015 and rs724078 displayed a significant association with semen parameters in the meta-analysis of two Japanese male cohorts. LIMITATIONS, REASONS FOR CAUTION Only four SNPs identified in the Hutterite GWAS were examined for associations with semen quality traits in a Japanese population. In addition, the linkage disequilibrium structures around the testing markers were different between ethnic groups. WIDER IMPLICATIONS OF THE FINDINGS Locus mapping studies using a set of tagging SNPs across the loci will be necessary in populations with larger sample sizes in order to understand the contribution of specific genes to semen quality. STUDY FUNDING/COMPETING INTEREST (S) This study was supported in part by the Mi...
An association study of four candidate loci for human male fertility traits with male infertility
This study was supported in part by the Ministry of Health and Welfare of Japan (1013201) (to T.I.), Grant-in-Aids for Scientific Research (C) (23510242) (to A.Ta.) from the Japan Society for the Promotion of Science, the European Union (BMH4-CT96-0314) (to T. I.) and the Takeda Science Foundation (to A.Ta.). None of the authors has any competing interests to declare. (Source: Human Reproduction)
Knowledge, attitudes and practices on HIV/AIDS and prevalence of HIV in the general population of Sucre, Bolivia.
CONCLUSIONS: Prevalence of HIV infection is very low and unsafe sex is relatively uncommon. Inadequate knowledge on HIV/AIDS and discriminatory attitudes towards PLWHA are extremely high and are associated to gender, ethnic and economic inequalities. PMID: 26001978 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)
Pacific Trade Pact Would Mean Higher Drug Prices, Says Report
Trans Pacific Partnership, now being negotiated by U.S., will keep low-cost generics off the market, says the Foundation for AIDS Research -- Read more on ScientificAmerican.com (Source: Scientific American - Official RSS Feed)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Andrew Pusipher Is HIV Positive, But His Wife And Kids Are Not. Here's Why.
33-year-old Andrew Pulsipher is HIV positive. He has a wife and three kids, and all of them are HIV negative. Pulsipher, who lives in Phoenix, Arizona, was born with HIV. Both of his parents died of AIDS when he was kid, so Pulsipher was raised by his aunt and uncle. When he met his wife Victoria and realized he wanted to start a family, Pulsipher was nervous about passing it on. So he and Victoria had his daughter, now five, through fertility treatments. But because Pulsipher's HIV is currently "undetectable," he was able to have his second two children naturally. Pulsipher told The Huffington Post: HIV is very modernized these days. I just went to the doctor today. They just check your levels and make sure you?re still undetectable. That?s everyone?s goal, to be undetectable...
Stopping Cancer Before It Starts
On May 20, 2015, New York State will host its Cancer Prevention Summit in Manhattan. This bold initiative is the work of the New York State Commissioner of Health, Dr. Howard Zucker, and his colleagues at the New York State Department of Health. Many health related organizations in New York are participating in the Summit, and the audience will be challenged with action points. I am honored to participate in the Cancer Prevention Summit as a speaker, and will introduce the keynote speaker, Dr. Graham Colditz, an internationally recognized leader in the prevention of cancer and other diseases. The Summit's focus is the primary prevention of cancer -- stopping cancer before it starts -- and leading experts will present their research and insights with those present, and remotely through a...
Uganda: Uganda Tipped On ICT for HIV Awareness
[EA Business] Kampala -HIV/AIDS activists in Uganda have suggest the government and NGOs integrate the use of modern information and communication technology platforms in sensitizing the public, particularly young people about HIV/AIDS. (Source: AllAfrica News: Health and Medicine)
Treating HIV in DRC: "They Couldn't Just Let Me Die Like That"
Field newsTreating HIV in DRC: &quot;They Couldn&#039;t Just Let Me Die Like That&quot; May 18, 2015 Despite the tremendous progresses made in the fight against HIV/AIDS, many patients in West and Central Africa still struggle to get the treatment they need. Barely a third of the people in those two regions who need anti-retroviral (ARV) treatment receive it. (Source: MSF News)
How Does a Decision Aid Help People Decide Whether to Disclose a Mental Health Problem to Employers? Qualitative Interview Study
Conclusions Data from our 13 participants suggest that the CORAL decision aid acts on several dimensions of decisional conflict: clarifying the pros and cons of different choices; increasing knowledge; structuring the decision making process; and clarifying needs and values. The current study indicated that it would be most effective when delivered by a professional well versed in employment and mental health matters such as a vocational adviser. The need for employers and policymakers to reduce the negative impact of disclosure is also highlighted. (Source: Journal of Occupational Rehabilitation)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Nigeria: HIV Vaccine - Experts Explore Viable Options
[Vanguard] AS Nigeria joins the rest of the world to mark the HIV Vaccine Awareness Day today, an Associate Professor of Paediatric Dentistry and Consultant at the Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria, Dr. Morenike Ukpong, has called for all hands to be on deck to ensure that all available HIV prevention methods reach people who need them. (Source: AllAfrica News: HIV-Aids and STDs)
Zambia: HIV/Aids - Epidemic of Fear
[Times of Zambia] The following article was written by Martin Choo, in his essay in the first edition of AIDS Today, a publication of the International HIV Alliance, a USA based organisation. The article sums up how HIV is "the epidemic of fear." (Source: AllAfrica News: Health and Medicine)
Adherence to PrEP and HIV Risk Among People Who Inject DrugsAdherence to PrEP and HIV Risk Among People Who Inject Drugs
How does PrEP adherence impact the risk of HIV infection? AIDS (Source: Medscape Today Headlines)
Hodgkin Lymphoma Is as Common as Non-Hodgkin in HIV PatientsHodgkin Lymphoma Is as Common as Non-Hodgkin in HIV Patients
This study compares HIV-infected patients with Hodgkin Lymphoma and Non-Hodgkin Lymphoma with respect to antiretroviral therapy exposure. HIV Medicine (Source: Medscape Today Headlines)
Zimbabwe: 10 Percent of Harare's 10,000 STI Cases Among Vendors
[New Zimbabwe] SEXUALLY transmitted infections are rife among vendors, accounting for 36 percent of cases recorded in Harare alone, the National AIDS Council (NAC) has said. (Source: AllAfrica News: Health and Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Zimbabwe: Same Name, Different People
[The Herald] A Harare woman is suffering stigma and discrimination after another person who shares her name appeared at the Harare Civil Court claiming her boyfriend deliberately infected her with HIV and was now stealing her ARVs. Chipo Kamuriwo of 183 Monavale Road, Milton Park, said she has not known peace since The Herald last week published the story about he namesake. (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: The Diary of a Medical Student - HIV-Aids Vaccine Will Revive Hope
[The Star] There is no doubt that having a HIV vaccine would be a miracle for all human kind. But as we approached World AIDS Vaccine day, I couldn't help but think of my own species -the female. And just how much more it would mean to us, and the world of difference it would create. (Source: AllAfrica News: HIV-Aids and STDs)
[Correspondence] HIV/AIDS registration in Pakistan
Meaningful national-level HIV/AIDS registration can only be imagined in Pakistan?an Islamic country of more than 185 million inhabitants, where people hesitate to discuss their sexual practices. Moreover, knowledge, attitude, and practices regarding HIV/AIDS are poor, not only within the general population, but also among general medical practitioners in Pakistan.1 As a result, a country previously regarded as low-prevalence but high risk has become a country with a concentrated HIV epidemic2 that is a potential threat to national and international health security. (Source: The Lancet Infectious Diseases)
[Correspondence] India's budget reduction and AIDS initiatives
India is ranked third in the world for AIDS prevalence, with 2·1 million people living with HIV. This lethal disease took the lives of about 130?000 people in 2013 alone across the country.1,2 Nevertheless, the pandemic is lessening its virulence, with a 57% fall in new cases during 2000?11 and a 29% fall in AIDS-related mortality during 2007?11.1 (Source: The Lancet Infectious Diseases)
[Comment] From the big three to the big four
The increasing global burden of viral hepatitis was recognised by the World Health Assembly with the passing of two resolutions, the first in 2010,1 followed by a second in 2014.2 These resolutions identified viral hepatitis as a global health issue needing an ?integrated and cost-effective approach? to its prevention, control, and management. At a global level, viral hepatitis is responsible for 1·44 million deaths every year (compared with 1·46 million deaths from HIV/AIDS, 1·20 million from tuberculosis, and 1·17 million from malaria). (Source: The Lancet Infectious Diseases)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
South Africa: Gauteng Health Hosts HIV and Aids Candlelight Memorial, 17 May
[SA Govt] The Gauteng Department of Health will on Sunday 17 May 2015, host a candlelight memorial in remembrance of those who succumbed to AIDS at Sedibeng. (Source: AllAfrica News: HIV-Aids and STDs)
Correction
Quesada AE, Tholpady A, Wanger A, et al. Utility of bone marrow examination for workup of fever of unknown origin in patients with HIV/AIDS. J Clin Pathol 2015;68:241&ndash;5. doi:10.1136/jclinpath-2014-202715 The following sentence has been amended to read: The average white blood cell count for all patients was x109/L (range 0.1&ndash;23.7 x109/L). The average haemoglobin was 91&nbsp;g/L (range 54&ndash;135&nbsp;g/L). The average platelet count was 146 x109/L (range 4&ndash;642 x109/L). Table 2 has also been amended to read: Table&nbsp;2Complete blood cell counts BM culture negativeBM culture positiveWhite blood cell count4 x109/L2.8 x109/LReference range: 4.5&ndash;11.0 x109/L0.1&ndash;23.7 x109/L1.2&ndash;5.6 x109/LHaemoglobin93&nbsp;g/L83&nbsp;g/LReference range: 54&ndash;135&nbsp;g/L...
Virtual support for paediatric HIV treatment decision making
Conclusions Combined multidisciplinary virtual input with adult expertise in resistance and newer agents, paediatric knowledge of pill swallowing, childhood formulations/weight banding and parental support, assists complex treatment decision making in paediatric HIV infection. The Virtual Clinic model could be applied to the management of other rare complex diseases of childhood within a clinical network. (Source: Archives of Disease in Childhood)
Answers to Epilogue questions: Troublesome Thai travels
Answers TO THE EPILOGUE QUIZ From questions on page 144 The answers to question 1 are C, E, H, I, J. Three broad categories of aetiologies can be considered for his renal impairment.NSAID use. Prerenal impairment secondary to dehydration, which should be readily reversible with volume replacement. Volume depletion alone can cause acute tubular necrosis. Infectious. Any patient returning from a tropical country with fever should have imported tropical illnesses high on the differential list. The activities of swimming in open water and eating partially cooked meat increased the likelihood of this patient having an imported tropical infective cause. Renal involvement is a recognised feature of a wide number of tropical illnesses, including leptospirosis, malaria, typhoid, viral haemorrhagic ...
Decision Aids in Serious Illness
Shared decision making is often challenging and never entirely rational. Even seemingly simple decisions, such as taking antibiotics for an upper respiratory tract infection or repairing a fractured bone, may encompass trade-offs, are influenced by cognitive biases, and can be clouded by emotion. Serious illness amplifies these biases and their effects. Decision making is even more complicated in the setting of advance care planning, when patients are trying to decide for their future selves rather than their current selves. (Source: JAMA Internal Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Tools to Promote Shared Decision Making in Serious Illness
This review of tools for shared decision making in serious illness finds that future randomized clinical trials are needed for further development of novel decision aids for serious diagnoses and key decisions. (Source: JAMA Internal Medicine)
Prevalence of hepatitis C antibodies in the population aged 16?80 years in the Community of Madrid 2008?2009
Together with AIDS, the burden of hepatitis C virus (HCV) in Spain heads the list of communicable diseases in terms of impact on public health. The aim of this study was to estimate the prevalence of HCV antibodies in the Community of Madrid, assess changes in recent years and analyse associated risk factors. Descriptive cross?sectional study of a target population consisting of Community of Madrid residents aged 16?80 years old. Two?stage cluster sampling was performed, with stratification by socioeconomic status and percentage immigrant population. The sampling frame consisted of public blood extraction centers attached to the Madrid Health Service. Seroprevalence of HCV antibodies, prevalence ratios by age groups in comparison with 1999 survey data and prevalence association with ...
Improving the Global HIV/AIDS Care Continuum for Adolescents
This Viewpoint discusses the importance of improving care globally for adolescents with human immunodeficiency virus (HIV)/AIDS. (Source: JAMA Pediatrics)
The Challenge of a "Functional Cure" for AIDS by Gene Modified HSCT Therapy.
The Challenge of a "Functional Cure" for AIDS by Gene Modified HSCT Therapy. Curr Stem Cell Res Ther. 2015 May 18; Authors: Xu L, Chen H, Zhang B Abstract Acquired immunodeficiency syndrome (AIDS), an infectious disease which is difficult to be cured, is regularly and effectively treated with anti-retroviral therapy in clinic. When considering about the defects of antiretroviral therapy (ART), patients need a new way to cure AIDS. With the development of genetic engineering technology and humanized mouse models, a new way has been found to achieve a "functional cure" for AIDS. One/some specific gene(s), such as CCR5 and CXCR4, can be knocked out to produce HIV-resisting cells, so as to achieve the purpose of curing AIDS. To find a safe and effective therapy for AIDS, t...
Use of new antiretroviral drugs and classes in Bahia, Brazil: a real life experience on salvage therapy of AIDS patients.
Authors: Brites C, Nóbrega I, Netto EM Abstract Antiretroviral therapy has significantly evolved in the last decade, with an increasing number of new drugs and classes. Currently, even heavily experienced patients can be successfully treated with new regimens. In Brazil, the recent incorporation of some new antiretroviral drugs made it possible to suppress HIV plasma viremia in most treated patients, with significant benefits in terms of quality of life and survival. However, little has been published on outcomes of patients under new drugs-based regimens. We reviewed the safety and efficacy of antiretroviral regimens using recently introduced drugs in Bahia. Our results confirm that patients using darunavir, raltegravir, enfuvirtide, or etravirine presented with a high rate of vi...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Late diagnosis and vulnerabilities of the elderly living with HIV/AIDS
CONCLUSION Late diagnosis of HIV infection or AIDS among the elderly happens in the secondary or tertiary service. Issues related to sexual life of the elderly are only questioned by health professionals after the diagnosis, also the time that condom use becomes absolute. It is believed that the investigation of the vulnerability of the elderly to HIV/AIDS allows for carrying out appropriate interventions for this population. OBJETIVO Identificar las vulnerabilidades de los ancianos con VIH/SIDA y el camino recorrido por ellos hasta el diagnóstico de la enfermedad. MÉTODO Investigación cualitativa conducida en ambulatorio especializado en el interior del Estado de São Paulo, de enero a junio de 2011. Se llevó a cabo entrevista semiestructurada con 11 añosos que se descubrieron infect...
Early Antiretroviral Therapy Is Protective Against Epilepsy in Children With Human Immunodeficiency Virus Infection in Botswana
Conclusions: Earlier initiation of cART may be protective against epilepsy in children with HIV. (Source: JAIDS Journal of Acquired Immune Deficiency Syndromes)
HIV-1 Coreceptor CXCR4 Antagonists Promote Clonal Expansion of Viral Epitope-Specific CD8+ T Cells During Acute SIV Infection in Rhesus Monkeys In Vivo
Conclusions: Antagonists of HIV coreceptors, particularly CXCR4, play an important role in the clonal expansion of SIV epitope-specific CD8+ T cells in vivo, thus inhibitors of chemokine receptors such as CXCR4 or CCR5 may contribute to the ability of epitope-specific CD8+ T cells to inhibit SIV or HIV infection. (Source: JAIDS Journal of Acquired Immune Deficiency Syndromes)
Transcutaneous Bone-anchored Hearing Aids Versus Percutaneous Ones: Multicenter Comparative Clinical Study
Conclusion: We can confirm that both transcutaneous and percutaneous techniques are effective in the rehabilitation of conductive hearing loss when conventional hearing aids cannot be used. However, both of the systems have some advantages and limitations in terms of audiological and surgical perspectives. (Source: Otology and Neurotology)
Comparison of Audiologic Results and Patient Satisfaction for Two Osseointegrated Bone Conduction Devices: Results of a Prospective Study
Conclusion: Amplification-wise, both devices are suitable treatments for hearing-impaired patients. Nevertheless, audiometric tests do not reflect subjective benefit and patients? satisfaction, and both options should be tested to provide each patient with the best possible hearing solution. The study further elucidates the importance and necessity of questionnaires in the process of evaluating the hearing benefit of hearing devices. (Source: Otology and Neurotology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
CROI 2015: Basic Science Review.
Authors: Stevenson M Abstract The 2015 Conference on Retroviruses and Opportunistic Infections (CROI) represents a forum that encompasses all facets of research on HIV/AIDS and its complications. CROI is a valuable venue for scientific and public health researchers, clinicians, policy makers, and community representatives to be updated on the latest advances in their specific areas of interest and beyond. CROI 2015 continued to surprise. New insights into the viral reservoirs that persist in the face of antiretroviral therapy were prominently featured, as were therapeutic approaches aimed at curtailing and eliminating persistent viral reservoirs in HIV-infected individuals. Basic science is providing surrogates that could be valuable in how viral reservoirs are measured and, ultima...
HIV Drug Therapy in the Americas 16-18 April 2015, Mexico City, Mexico.
Authors: PMID: 25967936 [PubMed - in process] (Source: Journal of the International AIDS Society)
San Francisco woman proves that HIV doesn't always cause AIDS: no symptoms after 23 years
(NaturalNews) In the 23 years since she was diagnosed with HIV, 61-year-old Loreen Willenberg of Sacramento, Calif., has never taken any drugs to restrain the virus. She has never shown symptoms or become ill from HIV or AIDS. She has experienced no drop in her CD4 T-cells, the immune... (Source: NaturalNews.com)
Simultaneous Multibeam Resource Allocation Scheme for Multiple Target Tracking
A colocated multiple-input multiple-output (MIMO) radar system has the ability to address multiple beam information. However, the simultaneous multibeam working mode has two finite working resources: the number of beams and the total transmit power of the multiple beams. In this scenario, a resource allocation strategy for the multibeam working mode with the task of tracking multiple targets is developed in this paper. The basis of our technique is to adjust the number of beams and their directions and the transmit power of each beam through feedback, with the purpose of improving the worst tracking performance among the multiple targets. The Bayesian Cram&#x00E9;r&#x2013;Rao lower bound (BCRLB) provides us with a lower bound on the estimated mean square error (MSE) of the target state. He...
A cross-sectional study of leukopenia and thrombocytopenia among Chinese adults with newly diagnosed HIV/AIDS.
Authors: Shen Y, Wang J, Wang Z, Shen J, Qi T, Song W, Tang Y, Liu L, Zhang R, Zeng Y, Lu H Abstract We conducted a cross-sectional study to determine the prevalence and risk factors of leukopenia and thrombocytopenia among Chinese adults with newly diagnosed HIV/AIDS. One thousand nine hundred and forty-eight newly diagnosed HIV-infected patients were enrolled between 2009 and 2010. Serum samples obtained from each individual were collected for complete blood count. Factors associated with the presence of leukopenia and thrombocytopenia were analyzed by multiple logistic regression. The overall prevalence of leukopenia and of thrombocytopenia was 33.2% and 15.6%, respectively. The prevalence of leukopenia was higher among females than among males (39.4% versus 31.2%). The prevalen...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
The Plain Jane of All Remedies
The Emperor of All Maladies, a PBS documentary by Ken Burns based on the Pulitzer prize-winning book of the same name, is promoted as a "biography" of cancer. However, it is more accurately described as a history of cancer treatment. And while I was hopeful there would be some relevant content on cancer prevention, it was no surprise that the focus was primarily on a cancer treatment model. The movie attracted sponsors such as David Koch, Cancer Treatment Centers of America and Genentech, to name a few. Such prosperous sponsors are not involved in our organization's work for Less Cancer. While I honor the work of all those seeking better treatments and hope for a cure, a sharp devil's advocate might wonder why these companies and individuals would support the work for prevention. What wou...
Revised Recommendations for Reducing the Risk of HIV Transmission by Blood and Blood Products
This guidance document provides you, blood establishments that collect blood or blood components, including Source Plasma, with FDA?s revised donor deferral recommendations for individuals with increased risk for transmitting human immunodeficiency virus (HIV) infection. (Source: CDC HIV/AIDS Prevention)
Share Your Ideas for Updating the National HIV/AIDS Strategy
The White House Office of National AIDS Policy invites you to share your ideas, feedback, and recommendations for updating the National HIV/AIDS Strategy. Comments are due May 22, 2015. (Source: PHPartners.org)
Role of myeloid cells in HIV-1-host interplay
This article will overview research that is examining the role of macrophage in virus-host interplay and will discuss features of this interplay that could impact efforts to eliminate myeloid cell reservoirs. (Source: Journal of NeuroVirology)
Kenya: There is Still Hope for Aids Vaccine, Researchers Say
[Capital FM] Nairobi -As the world prepares to mark HIV Vaccine Awareness Day, researchers in Kenya are concerned that the public may have lost faith in one ever being developed. (Source: AllAfrica News: Health and Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Cobicistat?vinblastine interaction and severe peripheral neuropathy
No abstract available (Source: AIDS)
Acute myocardial infarction following thalidomide treatment for AIDS-related ulcers
No abstract available (Source: AIDS)
Anti-tumor necrosis factor monoclonal antibody for steroid-dependent TB-IRIS in AIDS
No abstract available (Source: AIDS)
Impact of protease inhibitors on intracellular concentration of tenofovir-diphosphate among HIV-1 infected patients
Intracellular nucleoside reverse transcriptase inhibitor (NRTI) concentrations are associated with plasma HIV-1 response. Coadministration of protease inhibitors with NRTIs can affect intracellular concentrations due to protease inhibitor inhibition of efflux transporters. Tenofovir-diphosphate (TFV-DP) concentrations within peripheral blood mononuclear cells were compared among individuals receiving either atazanavir or darunavir-based regimens. There was a trend towards higher TFV-DP concentrations among women and among participants receiving atazanavir. TFV-DP intracellular concentrations were positively associated with undetectable plasma HIV-1 RNA. (Source: AIDS)
HAART and lungs: do HIV protease inhibitors impact cancer risk?
No abstract available (Source: AIDS)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Protease inhibitors exposure is not related to lung cancer risk in HIV smoker patients: a nested case?control study
Conclusion: These results suggest that the risk of lung cancer is not influenced by pharmacologically induced P450 cytochrome protease inhibitors inhibition among smokers or ex-smokers. (Source: AIDS)
Concurrency can drive an HIV epidemic by moving R0 across the epidemic threshold
Conclusion: Concurrency can be a driver of an HIV epidemic in sub-Saharan Africa for low levels of concurrency, although it is not decisive in MSM populations. A small increase in the level of concurrency can lead to R0 crossing the epidemic threshold in a sub-Saharan African setting. (Source: AIDS)
Effects of syndemics on HIV viral load and medication adherence in the multicentre AIDS cohort study
The objective of this study is to determine associations between intertwining epidemics (syndemics) and HIV medication adherence and viral load levels among HIV-positive MSM and to test whether adherence mediates the relationship between syndemics and viral load. Design: We analysed participant data collected between 2003 and 2009 from the Multicenter AIDS Cohort Study, a prospective HIV/AIDS cohort study in four U.S. cities. Methods: We conducted longitudinal analyses (repeated measures mixed models) to assess whether differences in viral load levels, undetectable viral load and self-reported HIV medication adherence were associated with count of syndemic conditions (substance use, depression symptoms and sexual risk behaviour, range 0?3), adjusting for race/ethnicity, age and income. M...
Changes in the contribution of genital tract infections to HIV acquisition among Kenyan high-risk women from 1993 to 2012
Conclusion: Bacterial vaginosis and HSV-2 have consistently been the largest contributors to HIV acquisition risk in the Mombasa Cohort over the past 20 years. Interventions that prevent these conditions would benefit women's health and could reduce their risk of becoming infected with HIV. (Source: AIDS)
The burden of dialysis-requiring acute kidney injury among hospitalized adults with HIV infection: a nationwide inpatient sample analysis
Conclusion: These data suggest that the incidence of dialysis-requiring AKI among hospitalized adults with HIV infection continues to increase, and that severe AKI remains a significant predictor of in-hospital mortality in this population. The increased incidence of dialysis-requiring AKI was largely explained by ageing of the HIV population and increasing prevalence of chronic non-AIDS comorbidities, suggesting that these trends will continue. (Source: AIDS)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
CD4+ gain percentile curves for monitoring response to antiretroviral therapy in HIV-infected adults
Objectives: We constructed CD4+ cell count gain percentile distributions standardized by baseline CD4+ cell count and assessed the association between poor CD4+ cell count gain and subsequent death and virological failure on antiretroviral therapy (ART). Design: Secondary analysis of 10 years of clinical data from a cohort of adults initiated on ART at the Themba Lethu clinic in Johannesburg, South Africa. Methods: The generalized additive model for location, scale and shape was used to construct percentile curves for CD4+ cell count gain standardized by baseline CD4+ cell count in the first 28 months of ART. Cox proportional models were used to assess the association between lower percentiles ( (Source: AIDS)
Young age at start of antiretroviral therapy and negative HIV antibody results in HIV-infected children when suppressed
Conclusion: Testing negative on standard HIV antibody tests occurs fairly commonly among HIV-infected children who started ART 3 months of age or less and are virally suppressed. It would be prudent in clinical practice to avoid HIV antibody tests among virally suppressed, early-treated children to prevent unnecessary confusion. (Source: AIDS)
Effect of selenium supplementation on CD4+ T-cell recovery, viral suppression and morbidity of HIV-infected patients in Rwanda: a randomized controlled trial
Conclusions: This randomized clinical trial demonstrated that 24-month selenium supplementation significantly reduces the rate of CD4+ cell count decline among ART-naive patients. (Source: AIDS)
White matter microstructure among youth with perinatally acquired HIV is associated with disease severity
Conclusion: Our findings suggest that PHIV youth have a higher risk of alterations in white matter microstructure than typically developing youth, and certain alterations are related to past disease severity. Further, white matter alterations potentially mediate associations between HIV disease and working memory. (Source: AIDS)
Low cross-neutralization of hepatitis C correlates with liver disease in immunocompromized patients
Conclusion: Serum neutralization in HIV-coinfected patients and HCV-infected liver transplant recipients is poor enhancing HCV entry through HVR1/SR-BI interplay. This may contribute to the severity of hepatitis C in these settings. (Source: AIDS)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Identification and characterization of a subpocket on the N-trimer of HIV-1 Gp41: implication for viral entry and drug target
Conclusion: These data have provided important information for the structure?function relationship of HIV-1 gp41 and for the development of antiviral entry inhibitors. (Source: AIDS)
Dendritic cell type-specific HIV-1 activation in effector T cells: implications for latent HIV-1 reservoir establishment
Conclusions: In this study, we show that HIV-1 provirus residing in effector T cells is activated from latency by tissue-specific dendritic cell subsets and other immune cells with remarkably different efficiencies. Our new assay system points to an important, neglected aspect of HIV-1 research: the ability of other immune cells, especially dendritic cells, to differentially affect latency establishment as well as virus reactivation. (Source: AIDS)
Multilayered HIV-1 gag-specific T-cell responses contribute to slow progression in HLA-A*30-B*13-C*06-positive patients
Conclusion: We conclude that a single ?appropriate? Gag-specific T-cell response appears to be sufficient to protect patients from disease progression. HLA-A*30-B*13-C*06-positive individuals benefited from having a choice of numerous immunodominant gag epitopes for T cells to react. The study offers new insight for future design of T-cell-based HIV-1 vaccine. (Source: AIDS)
A tale of two viruses: HIV, Ebola and health systems
No abstract available (Source: AIDS)
HIV-infected adults experience accentuated but not accelerated ageing
No abstract available (Source: AIDS)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Two recent studies find Depo-Provera use increases HIV risk
No abstract available (Source: AIDS)
Burkina Faso: What a Funding Crisis Is Doing to Aids Patients
[IRIN] Ouagadougou -For years you couldn't tell if someone in Burkina Faso had HIV/AIDS just by looking at them. Now it's getting easier again because cuts in food assistance are depriving them of nutrition, AIDS advocates say. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: Appraising Nigeria's HIV/Aids Control Efforts
[Leadership] Medical experts observe that the incidence of HIV and AIDS in Nigeria poses a serious threat to the socio-economic development of the country. (Source: AllAfrica News: HIV-Aids and STDs)
Variations in the Role of Social Support on Disclosure Among Newly Diagnosed HIV-Infected People Who Inject Drugs in Vietnam
Abstract Stigma and perceived social support can influence the decision to disclose HIV positive status, especially for people who inject drugs (PWID). In this analysis, the association between social support and HIV disclosure among 336 newly diagnosed HIV-infected PWID in Northern Vietnam was assessed. One month after diagnosis, 34.8 % of participants had not disclosed to anyone. Disclosure to anyone and to a family member specifically, was associated with baseline social support in the form of positive interactions and a history of incarceration. Disclosing to a family member was less likely among those who had unprotected sex in the previous 3 months. Disclosure to an injecting partner was more likely among those with a history of being in a drug treatment program, knowing s...
Trade agreement could limit access to medicines
If approved in its leaked form, the Trans-Pacific Partnership would pose barriers for generic drugs to enter the market and keep drug prices high, warns the Foundation for Aids Research (Source: Chemistry World | Latest News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Cancer Treatment in Patients With HIV Infection and Non-AIDS-Defining Cancers: A Survey of US Oncologists [Original Contributions]
Conclusion: Provider-level factors are associated with delivery of nonstandard cancer treatment to HIV-infected patients. Policy change, provider education, and multidisciplinary collaboration are needed to improve access to cancer treatment. (Source: Journal of Oncology Practice)
Partners Connected Health To Consider Using iThermonitors
http://media.boston.cbslocal.com/CBSBOS_1405201517464800000AA.mp4 BOSTON (CBS) &#8211; Eighteen-month old Isla Woulfe of Malden is a happy, healthy child, but a few months ago when she spiked a fever, she had a seizure. ?It was in the middle of the night and so obviously I was really nervous,? says her mom, Alyssa Woulfe. Afraid it might happen again, Alyssa tried a new device called an iThermonitor. Placed under the armpit with an adhesive patch and synced through Bluetooth with a smartphone or tablet, the iThermonitor records a child&#8217;s temperature every four seconds. If the temperature rises above or below a preset threshold, the caregiver is alerted ?It was great because I could get a little sleep,? says Alyssa. ?And I didn&#8217;t have to set my alarm every ho...
Factors related to NT-proBNP levels in HIV patients aged over 40 years.
CONCLUSIONS: We found, with the limitations of a small serie, that higher levels of NTproBNP in HIV patients could be linked to the occurrence of cardiovascular events, this fact suggest that NTpro BNP could be used in patients at moderate or high vascular risk in order to optimise the primary prevention of vascular events. PMID: 25960760 [PubMed] (Source: AIDS Research and Therapy)
Hundreds with HIV Could Donate Organs to Others with HIV
Although ban was lifted on such surgeries in 2013, none has taken place, researchers say Source: HealthDay Related MedlinePlus Pages: HIV/AIDS, Organ Transplantation (Source: MedlinePlus Health News)
Africa: Making Global Fund Money Work for Young People in the HIV Response
[GFO] In many parts of the world, the HIV epidemic has a new face: the face of a young person. The promise of the next generation could be dramatically restricted without smart, targeted investments in reaching these young people, particularly adolescent girls and young key populations. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
South Africa: Science and Technology on Creation of Forum to Strengthen HIV Research in Africa
[SA Govt] The Department of Science and Technology (DST) is planning to create a forum to strengthen HIV research, not only in South Africa, but throughout the African continent. (Source: AllAfrica News: HIV-Aids and STDs)
Zimbabwe: Self-Testing - Brave New Approach to HIV Fight
[The Herald] Total elimination of HIV is a herculean task for the government and its development partners as it calls for innovative approaches in HIV prevention, treatment and care. (Source: AllAfrica News: HIV-Aids and STDs)
Ethiopia: A Lot Can Happen in 15 Years
[Global Fund] Remarks delivered at the closing session of the 7-8 May 2015 Partnership Forum in Addis Ababa, Ethiopia. (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: Plea for HIV Programmes
[The Star] The National Council for Population and Development director in-charge of communication, advocacy and education Peter Nyakwara has urged counties to design new and effective ways of fighting HIV. (Source: AllAfrica News: HIV-Aids and STDs)
Malawi: Do Not Stop Medication Because of Prayers - Manet+
[Malawi News Agency] Lilongwe -The Malawi Network of People Living with HIV (MANET+) says it might consider seeking legal actions against faith organisations that are encouraging people to stop taking Antiretroviral Treatment (ARVs). (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Malawi: Malawi Making Commendable Progress in HIV Management
[Malawi News Agency] Acting National Executive Director of National Aids Commission (NAC), Davie Kalomba says as a country we need to pat ourselves on the back as we have made commendable progress in managing HIV. (Source: AllAfrica News: HIV-Aids and STDs)
Pretreatment platelet count improves the prognostic performance of the TNM staging system and aids in planning therapeutic regimens for nasopharyngeal carcinoma: a single-institutional study of 2,626 patients.
CONCLUSIONS: Pretreatment platelet count, when combined with TNM classification, is a useful indicator for metastasis and survival in patients with NPC. It may improve the predictive value of the TNM classification and help to identify patients likely to benefit from more aggressive therapeutic regimens. PMID: 25962816 [PubMed - in process] (Source: Chinese Journal of Cancer)
Addressing preference heterogeneity in public health policy by combining Cluster Analysis and Multi-Criteria Decision Analysis: Proof of Method
Abstract The use of subgroups based on biological-clinical and socio-demographic variables to deal with population heterogeneity is well-established in public policy. The use of subgroups based on preferences is rare, except when religion based, and controversial. If it were decided to treat subgroup preferences as valid determinants of public policy, a transparent analytical procedure is needed. In this proof of method study we show how public preferences could be incorporated into policy decisions in a way that respects both the multi-criterial nature of those decisions, and the heterogeneity of the population in relation to the importance assigned to relevant criteria. It involves combining Cluster Analysis (CA), to generate the subgroup sets of preferences, with Multi-Criteri...
Prospects for Malaria Elimination in Mesoamerica and Hispaniola
by Sócrates Herrera, Sergio Andrés Ochoa-Orozco, Iveth J. González, Lucrecia Peinado, Martha L. Quiñones, Myriam Arévalo-Herrera Malaria remains endemic in 21 countries of the American continent with an estimated 427,000 cases per year. Approximately 10% of these occur in the Mesoamerican and Caribbean regions. During the last decade, malaria transmission in Mesoamerica showed a decrease of ~85%; whereas, in the Caribbean region, Hispaniola (comprising the Dominican Republic [DR] and Haiti) presented an overall rise in malaria transmission, primarily due to a steady increase in Haiti, while DR experienced a significant transmission decrease in this period. The significant malaria reduction observed recently in the region prompted the launch of an initiative for Malaria Elimination in...
The tumor virus landscape of AIDS-related lymphomas
Immunodeficiency dramatically increases susceptibility to cancer as a result of reduced immune surveillance and enhanced opportunities for virus-mediated oncogenesis. Although AIDS-related lymphomas (ARLs) are frequently associated with known oncogenic viruses, many cases contain no known transforming virus. To discover novel transforming viruses, we profiled a set of ARL samples using whole transcriptome sequencing. We determined that Epstein-Barr virus (EBV) was the only virus detected in the tumor samples of this cohort, suggesting that if unidentified pathogens exist in this disease, they are present in &lt;10% of cases or undetectable by our methods. To evaluate the role of EBV in ARL pathogenesis, we analyzed viral gene expression and found highly heterogeneous patterns of viral tran...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Erratum to: Alcohol-Related Diagnoses and All-Cause Hospitalization Among HIV-Infected and Uninfected Patients: A Longitudinal Analysis of United States Veterans from 1997 to 2011
(Source: AIDS and Behavior)
Is Location of Sex Associated with Sexual Risk Behaviour in Men Who Have Sex with Men? Systematic Review of Within-Subjects Studies
Abstract To understand associations between location of sex and sexual risk, it is most helpful to compare sexual encounters within persons. We systematically reviewed within-subjects comparisons of sexual encounters reported by men who have sex with men (MSM) with respect to location of sex. Within-subjects comparisons of sexual risk and location of sex were eligible if they collected data post-1996 from samples of MSM. We independently screened results and full-text records in duplicate. Of 6,336 deduplicated records, we assessed 138 full-text studies and included six, most of which compared unprotected anal intercourse against other anal intercourse. This small, but high quality, body of evidence suggests that associations between attendance at sex-on-premises venues and person...
Exploring risk of experiencing intimate partner violence after HIV infection: a qualitative study among women with HIV attending postnatal services in Swaziland
Conclusions The results highlight a need to mitigate the risk of IPV for women with HIV in shorter and longer terms in Swaziland. While broader changes are needed to resolve gender disparities, practical steps can be institutionalised within health facilities to reduce, or avoid increasing, IPV pathways for women with HIV. These might include mutual disclosure between partners, greater engagement of Swazi males with HIV services, and promoting positive masculinities that support and protect women. Trial registration number NCT01694862. (Source: BMJ Open)
Mervyn Susser (1921-2014): Fighter for Social Justice and Pioneer in Epidemiology.
Authors: Fee E, Brown TM, Manuelpillai W Abstract Mervyn Susser, MB, Bch, FRCP(E), DPH, was one of the towering figures of epidemiology in the 20th century.(1) From the start, he drew attention to the interrelationships between health, disease, and social injustice. His influence extended to the foundations of life course epidemiology, genetic epidemiology, and global health (later including HIV/AIDS), among other areas. Much of his work was conducted with his wife and intellectual partner, Zena Stein. (Am J Public Health. Published online ahead of print May 14, 2015: e1-e4. doi:10.2105/AJPH.2015.302633). PMID: 25973815 [PubMed - as supplied by publisher] (Source: American Journal of Public Health)
Impact of TB on the survival of people living with HIV infection in England, Wales and Northern Ireland
Discussion The unexpected high mortality in patients with HIV-TB in a population with good healthcare access and ART availability highlights the importance of improving active and latent TB case-finding among patients with HIV, and HIV-testing among patients with TB, to ensure appropriate and prompt treatment initiation for both diseases. (Source: Thorax)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
A good night for a bad day
A 40-year-old-man was admitted to the emergency department for sudden dyspnoea. He had no medical history. He had given up smoking a few years back having had a cigarette consumption of 10 packs/year. He stopped drinking alcohol 2&nbsp;months ago. He had been a drug (heroin and cocaine) misuser for 15&nbsp;years. Methadone had been introduced as a substitution therapy since 2012. He came back from a journey to China 1&nbsp;month beforehand. The day of admission, he awoke with dyspnoea and a dry cough. In the emergency room, he had no fever, and lung and cardiac auscultation was normal. Oxygen saturation was 94% and the respiratory rate was over 20/min. Laboratory findings showed an increase in the leucocyte count at 18.1 109/L. C reactive protein was normal (6.5x10&ndash;3&nbsp;g/L). Arter...
A review of how the quality of HIV clinical services has been evaluated or improved
To examine approaches being used to evaluate and improve quality of HIV clinical services we searched the MEDLINE, Cochrane Library collection, EMBASE, Global Health, and Web of Science databases for articles and abstracts focused on evaluating or improving quality of HIV clinical services. We extracted country income level, targeted clinical services, and quality evaluation approaches, data sources, and criteria. Fifty journal articles and 46 meeting abstracts were included. Of the 96 studies reviewed, 65% were programme evaluations, 71% focused on low- and middle-income countries, and 65% focused on antiretroviral therapy services. With regard to quality, 45% used a quality improvement model or programme, 13% set a quality threshold, and 51% examined patient records to evaluate quality. ...
HSV oropharyngeal shedding among HIV-infected children in Tanzania
Herpes simplex virus (HSV) oral shedding has not been studied among HIV-positive children in Africa. We sought to evaluate longitudinal oral HSV reactivation in HIV-positive and -negative children. Twenty HIV-positive antiretroviral-naive and 10 HIV-negative children aged 3&ndash;12 years in Tanzania were followed prospectively for 14 days. Oral swabs were collected daily and submitted for HSV DNA PCR analysis. Clinical data were collected via chart review and daily diaries. HSV DNA was detected in 10 (50%) of HIV-positive and 4 (40%) of HIV-negative children. Children who shed HSV had virus detected in a median of 21.4% of samples; shedding was intermittent. Median CD4 count among HIV-infected children was 667 cells/&micro;L in those with positive HSV DNA and 886 cells/&micro;L in those w...
Should we screen heterosexuals for extra-genital chlamydial and gonococcal infections?
This study not only confirmed a large reservoir of extra-genital infection amongst men who have sex with men, but also demonstrates that a comparable reservoir of extra-genital infection is present amongst heterosexual women. Our study adds to the mounting evidence that extra-genital site testing in heterosexual women should occur when oral or anal sexual activity is reported. (Source: International Journal of STD and AIDS)
HIV care engagement within 30 days after hospital discharge among patients from a Thai tertiary-care centre
A cohort study was conducted to assess the rate of follow-up visit within 30 days after hospital discharge and to determine factors associated with no follow-up among Thai HIV-infected adults during the period from November 2012 to October 2013. Of the 120 eligible patients, 76 (63%) were males, median age was 40 years, and 57 (48%) were newly diagnosed with HIV infection. The rate of follow-up within 30 days after hospital discharge was 69%. Independent factors associated with no follow-up were no caregiver (adjusted odds ratio [aOR] 7.82; p = 0.002), age (aOR 1.06; p = 0.007 for each year younger), being immigrant (aOR 5.10; p = 0.03) and monthly household income less than $US 300 (aOR 2.99; p = 0.04). These findings suggest the need for interventions to improve care engagement including...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Changes in the pattern of Kaposi's sarcoma at Ocean Road Cancer Institute in Tanzania (2006-2011)
Tanzania has high human immunodeficiency virus and human herpes virus-8 rates linked to Kaposi&rsquo;s sarcoma. We conducted a study at the Ocean Road Cancer Institute in Dar es Salaam, Tanzania to examine changes in proportions of Kaposi&rsquo;s sarcoma to all cancers over the period (2006&ndash;2011) of increased acquired immune deficiency syndrome management by anti-retroviral therapy. We included 1504 Kaposi&rsquo;s sarcoma cases from Ocean Road Cancer Institute and abstracted information regarding age, gender, human immunodeficiency virus and tuberculosis, anti-retroviral therapy duration and Kaposi&rsquo;s sarcoma lesions. Male Kaposi&rsquo;s sarcoma patients (59.6%) were older (42.1 &plusmn; 11.5 years) than women (40.4%) (36.2 &plusmn; 9.6 years). Kaposi&rsquo;s sarcoma proportions...
Urinary protein-to-creatinine ratio versus 24-h proteinuria in the screening for nephropathy in HIV patients
To determine the correlation between protein-to-creatinine ratio and 24-h urinary protein, proteinuria was measured in 45 patients attending a public HIV clinic in Porto Alegre, Brazil, using 24-h urinary protein excretion (24hUP) and urinary protein-to-creatinine ratio. Spearman&rsquo;s correlation test was done to evaluate the association between spot protein-to-creatinine ratio and 24hUP. The limits of agreement between the two methods were analysed by the Bland&ndash;Altman method. For protein excretion &lt;1 g/day, limits (95%) of agreement of protein-to-creatinine ratio and 24hUP were +0.112 and &ndash;0.097 g/day. A strong correlation (r = 0.957) was found between protein-to-creatinine ratio and 24hUP excretion. The conclusion is that the protein-to-creatinine ratio in spot urine sp...
Components of resilience in gender: a comparative analysis of HIV outcomes in Kenya
Gender is a critical concept of human immunodeficiency virus (HIV) sexual risk; yet, few studies have examined the intersection between risk and protective factors associated with incidence of HIV among couples. The paper examines gender-specific constructs of resiliency among couples in Kenya. Using data from the Demographic and Health Surveys, Kenya (2008/2009), we apply logistic regression techniques to analyse three resilience-related outcomes (condom use, HIV test and knowing an HIV test place) in estimating the gender differences and barriers to HIV/AIDS sexual risk. Men&rsquo;s outcomes were significantly associated with previous HIV testing, urban residence, being insured and higher levels of education. Predictors for women&rsquo;s indicators included previous experience of sexual ...
Prevalence of suicidal ideation and associated factors among HIV-positive MSM in Anhui, China
The aim of this study was to investigate the prevalence and factors associated with suicidal ideation among HIV-positive men who have sex with men (MSM) in Anhui, China. A cross-sectional study was conducted to recruit HIV-positive MSM in Anhui, China. A total of 184 HIV-positive MSM gave informed consent and completed the interview. Correlates of suicidal ideation were assessed using multivariable logistic regression. Fifty-seven (31%) of HIV-positive MSM had suicidal ideations within six months before the interview. Multivariable analyses showed that learning of their HIV status in the past 12 months (adjusted odds ratio (AOR) = 3.4, 95% CI = 1.6&ndash;7.3), perceived HIV stigma (AOR = 2.4, 95% CI = 1.1&ndash;5.2), depression symptoms (AOR = 2.6, 95% CI = 1.1&ndash;5.9) and anxiety sympt...
An audit of HIV care in English prisons
Previous studies have highlighted disparities in care and outcomes in HIV-positive prisoners compared to HIV-positive individuals in the population. We audited clinical outcomes of HIV-positive prisoners accessing care in 2011. Public Health England were notified of 161 prisoners with HIV in the time period studied. Audit proformas were sent to clinics reporting prisoners to the genitourinary medicine clinic activity dataset in 2011. Thirty-two clinics responded. Data for 151 HIV-positive prisoners were reported by 12 clinics, with the other clinics not reporting any prisoners. Outcomes were compared to a previous audit, British HIV Association (BHIVA) and the National AIDS Trust guidelines. Initial CD4 counts were available for 101 patients, of which 42/101 had CD4 &lt;350 cells/mm3. At r...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Condylomata acuminata in the neovagina after male-to-female reassignment treated with CO2 laser and imiquimod
We report a case of condylomata acuminata arising on the neourethral meatus and the transplanted skin of the neovagina in a male-to-female transsexual, which was successfully treated with CO2 laser irradiation followed by topical application of imiquimod cream on the residual warts. This is a first report of using imiquimod cream for condylomata acuminata arising on the neovagina in a male-to-female transsexual. (Source: International Journal of STD and AIDS)
Lichenoid drug reaction to isoniazid presenting as exfoliative dermatitis in a patient with acquired immunodeficiency syndrome
We report here a rare case of lichenoid drug reaction to isoniazid presenting as exfoliative dermatitis in a patient with acquired immunodeficiency syndrome. (Source: International Journal of STD and AIDS)
A case of proliferative diabetic retinopathy that regressed on human immunodeficiency virus treatment
We report the case of a patient with proliferative diabetic retinopathy, who was later found to have human immunodeficiency virus infection that progressed rapidly. However, we could not determine the clinical course after the onset of human immunodeficiency virus because the patient died shortly after it was detected. In this patient, the activity of proliferative diabetic retinopathy showed regression after treatment for human immunodeficiency virus was initiated. (Source: International Journal of STD and AIDS)
Malignant lues in an immunocompetent patient
We present the case of a 57-year-old homosexual man referred to our department due to a 4-month history of a disseminated, slightly painful, nodular-ulcerative cutaneous eruption associated with low-grade fever, malaise and aesthenia. Regarding the clinical features and serological and histopathological findings, the diagnosis of syphilis maligna was assumed. Serology for HIV was repeatedly negative. This case is interesting, not only because a very uncommon form of secondary syphilis was identified but also for being diagnosed in an immunocompetent patient. Lack of awareness of this type of presentation delays the diagnosis and treatment, leading to an increase in morbidity and spread of infection. (Source: International Journal of STD and AIDS)
Addressing preference heterogeneity in public health policy by combining Cluster Analysis and Multi-Criteria Decision Analysis: Proof of Method
The use of subgroups based on biological-clinical and socio-demographic variables to deal with population heterogeneity is well-established in public policy. The use of subgroups based on preferences is rare, except when religion based, and controversial. If it were decided to treat subgroup preferences as valid determinants of public policy, a transparent analytical procedure is needed. In this proof of method study we show how public preferences could be incorporated into policy decisions in a way that respects both the multi-criterial nature of those decisions, and the heterogeneity of the population in relation to the importance assigned to relevant criteria. It involves combining Cluster Analysis (CA), to generate the subgroup sets of preferences, with Multi-Criteria Decision Analysis...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Unexpected Diagnosis of Cerebral Toxoplasmosis by 16S and D2 Large-Subunit Ribosomal DNA PCR and Sequencing [Case Reports]
The protozoan parasite Toxoplasma gondii causes severe opportunistic infections. Here, we report an unexpected diagnosis of cerebral toxoplasmosis. T. gondii was diagnosed by 16S and D2 large-subunit (LSU) ribosomal DNA (rDNA) sequencing of a cerebral biopsy specimen and confirmed by T. gondii-specific PCR and immunohistochemistry. The patient was later diagnosed with HIV/AIDS. (Source: Journal of Clinical Microbiology)
Secretome protein signature of human gastrointestinal stromal tumor cells.
Authors: Berglund E, Daré E, Branca RM, Akcakaya P, Fröbom R, Berggren PO, Lui WO, Larsson C, Zedenius J, Orre L, Lehtiö J, Kim J, Bränström R Abstract Strategies for correct diagnosis, treatment evaluation and recurrence prediction are important for the prognosis and mortality rates among cancer patients. In spite of major improvements in clinical management, gastrointestinal stromal tumors (GISTs) can still be deadly due to metastasis and recurrences, which confirms the unmet need of reliable follow-up modalities. Tumor-specific secreted, shed or leaked proteins (collectively known as secretome) are considered promising sources for biomarkers, and suitable for detection in biofluids. Herein, we stimulated cell secretion in the imatinib-sensitive GIST882 cell line and profile...
Money May Convince Smokers to Quit
Study found financial incentives were better alternative than free counseling, cessation aids (Source: WebMD Health)
The music teacher who can't hear:  27-year-old stopped from studying the subject at school defies the odds to land 'dream job'
John Thompson, from east London, was born prematurely with a severe hearing impairment, leaving him deaf in both ears. He can teach thanks to heavy-duty hearing aids and his ability to read lips. (Source: the Mail online | Health)
How To Feed A Numbat: Zoo Cookery Aids Endangered Species
Zoo nutritionists these days have to do more than try to keep displayed animals happy and healthy. Sometimes the goal is to bring endangered wildlife back from the brink.&raquo; E-Mail This (Source: NPR Health and Science)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Aspidosperma subincanum II. Usefulness of uleine and ribonucleic fragments in the treatment of AIDS patients
Aids patients were treated during a year with three different food supplements commercially available: para-pau-aspido (Aspidosperma subincanum Mart. ex A. DC., Apocynaceae); 2Leid (nucleic acids and cytokines); and Para Immuno (propolis, pollen and royal jelly). All foods, given either alone or in combination, proved useful to all AIDS patients who received the supplements, be these under tri-therapy (Triomine: stavudine, lamivudine, névirapine) or left unattended. (Source: Revista Brasileira de Farmacognosia)
Ebola Not Mutating Beyond 'Normal' Rate, Scientists Say
New genetic information aids planning for future outbreaks Source: HealthDay Related MedlinePlus Page: Ebola (Source: MedlinePlus Health News)
Persistence yields progress in AIDS vaccine research
After 30 years of working on AIDS research, an American lab has developed new vaccine candidates that appear promising enough to consider advancing into clinical trials within the next two years. (Source: ScienceDaily Headlines)
South Africa: Plans in Place to Deal With High Teen HIV Rates
[Parliament of South Africa] The Portfolio Committee on Basic Education heard today that HIV-related deaths were declining in all age groups, accept for adolescents where infection rates have doubled. Mr Granville Whittle, Deputy Director-General in the Department of Basic Education, said there are 2 363 new HIV infections each week among African girls. "The epidemic amongst adolescents is growing. We are not on track to achieve an Aids-free generation." (Source: AllAfrica News: HIV-Aids and STDs)
Kenya: Partnership Forum 2015
[Global Fund] Phelister Abdallah spoke at the opening session of the Partnership Forum in Addis, aiming to voice the concerns of sex workers and other people most affected by HIV, TB and malaria. She did so by mentioning her personal story. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
South Africa: DST to Set Up Forum for HIV Research
[SAnews.gov.za] Pretoria -The Department of Science and Technology (DST) is planning to create a forum to strengthen HIV research, not only in South Africa, but throughout the African continent. (Source: AllAfrica News: HIV-Aids and STDs)
End Ban on Gay Men Donating Blood, FDA ProposesEnd Ban on Gay Men Donating Blood, FDA Proposes
The draft guidance to blood centers would eliminate a lifetime deferral of donations from gay and bisexual men dating back to the dawn of the AIDS epidemic. Medscape Medical News (Source: Medscape Medical News Headlines)
Judge Rules Against Abstinence-Only Sex Ed Program
A judge in Fresno County, California, has ruled against an abstinence-only sex education program, saying a school district violated state law by failing to provide adequate instruction on sexual health and HIV prevention. Fresno County Superior Court Judge Donald Black said a lawsuit against Clovis Unified School District was justified because the district failed to offer "comprehensive, medically accurate, objective and bias-free" education, in violation of the California Comprehensive Sexual Health & HIV/AIDS Prevention Act, adopted in 2003. The law requires public schools to "provide a pupil with the knowledge and skills necessary to protect his or her sexual and reproductive health from unintended pregnancy and STDs." "Given the high social cost of teen pregnancy and similar toll on...
Informal Caregiver Characteristics Associated with Viral Load Suppression Among Current or Former Injection Drug Users Living with HIV/AIDS
Abstract Few studies have examined the association between having an informal (unpaid) caregiver and viral suppression among persons living with HIV/AIDS (PLHIV) who are on antiretroviral therapy. The current study examined relationships between caregivers? individual and social network characteristics and care recipient viral suppression. Baseline data were from the BEACON study caregivers and their HIV seropositive former or current drug using care recipients, of whom 89 % were African American (N = 258 dyads). Using adjusted logistic regression, care recipient?s undetectable viral load was positively associated with caregiver?s limited physical functioning and negatively associated with caregivers having few family members to turn to for problem solving, a greater numb...
Mediation of an Efficacious HIV Risk Reduction Intervention for South African Men
Abstract ?Men, Together Making a Difference!? is an HIV/STD risk-reduction intervention that significantly increased self-reported consistent condom use during vaginal intercourse compared with a health-promotion attention-control intervention among men (N = 1181) in Eastern Cape Province, South Africa. The present analyses were designed to identify mediators of the intervention?s efficacy. The potential mediators were Social Cognitive Theory (SCT) constructs that the intervention targeted, including several aspects of condom-use self-efficacy, outcome expectancies, and knowledge. Mediation was assessed using a product-of-coefficients approach where an ? path (the intervention?s effect on the potential mediator) and a ? path (the potential mediator?s effect on the ou...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Pre-exposure Prophylaxis Adherence Measured by Plasma Drug Level in MTN-001: Comparison Between Vaginal Gel and Oral Tablets in Two Geographic Regions
We examined recent adherence as measured by plasma tenofovir (TFV) concentration in participants of MTN-001, a phase 2 cross-over trial comparing oral tablet and vaginal gel formulations of TFV among 144 HIV-uninfected women at sites in the United States (U.S.) and sub-Saharan Africa (SSA). Adherence to daily product use was higher in the U.S. than in the SSA sites. Within region, however, adherence was similar between products. In the U.S., gel adherence was higher among married women, and lower among women using male condoms and injectable contraceptives. At the SSA sites, gel adherence was lower for younger women. Inconsistent adherence points to challenges in use of daily PrEP, even during a trial of short duration. (Source: AIDS and Behavior)
Repeat Use of Post-exposure Prophylaxis for HIV Among Nairobi-Based Female Sex Workers Following Sexual Exposure
In this study we analyze patterns of repeated post-exposure prophylaxis (PEP) access in the context of a large FSW program in Nairobi. During close to 6000 person-years of follow-up, 20 % of participants (n = 1119) requested PEP at least once and 3.7 % requested PEP more than once. Repeat PEP users were younger, had a higher casual partner volume, and were more likely to use condoms with casual and regular partners, have a regular partner, and test for HIV prior to enrolment. Barriers to PEP included stigma, side effects, and lack of knowledge, suggesting repeated promotion may be required for higher rates of uptake. A small subset of FSW, potentially those with heightened risk perception, showed a higher frequency of PEP use; these individuals may be most amenable to rollout of pre-ex...
Depression and Social Stigma Among MSM in Lesotho: Implications for HIV and Sexually Transmitted Infection Prevention
Abstract Social stigma is common among men who have sex with men (MSM) across Sub-Saharan Africa, and may influence risks for HIV and sexually transmitted infections (STIs) via its association with depression. We conducted a cross-sectional study of 530 MSM in Lesotho accrued via respondent-driven sampling. Using generalized structural equation models we examined associations between stigma, social capital, and depression with condom use and testing positive for HIV/STIs. Depression was positively associated with social stigma experienced or perceived as a result of being MSM. In contrast, increasing levels of social cohesion were negatively associated with depression. Social stigma was associated with testing positive for HIV; however, this association did not appear to be mediat...
HIV Testing Among Spanish Youth: Analysis of the Mediating Role of the Big Five Personality and Other Psychological Factors
Abstract Early diagnosis of HIV improves the effectiveness of treatments and stops the progression of the disease. The influence of personality and other psychological variables in testing for HIV is analyzed. The first part of the study is composed of 4,929 young people (M age = 20.45, SD = 2.16). For the second part, young heterosexuals who participated in a broader project on HIV prevention were selected (n = 240, M age = 20.78, SD = 2.29). Only 23.3 % of the total sample have ever been tested for HIV antibodies. The main reason for not testing was fear of positive result (25.4 %). Statistically significant differences in Agreeableness (p = .027), Trust (p = .022) and Straightforwardness (p = .024) were found between HIV-tested and not HIV-tested youth. Trust ...
Service delivery interventions to improve adolescents' linkage, retention and adherence to antiretroviral therapy and HIV care
ConclusionsThis review identified limited evidence on the effectiveness of service delivery interventions to support adolescents' linkage from HIV diagnosis to ART initiation, retention on ART and adherence to ART. Although recommendations are qualified because of the small numbers of studies and limited methodological quality, offering individual and group education and counselling, financial incentives, increasing clinic accessibility and provision of specific adolescent?tailored services appear promising interventions and warrant further investigation. (Source: Tropical Medicine and International Health)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
HIV infection is associated with an increased prevalence of coronary noncalcified plaque among participants with a coronary artery calcium score of zero: Multicenter AIDS Cohort Study (MACS)
ConclusionsAmong men with CAC scores of zero, HIV infection is associated with an increased prevalence of noncalcified coronary plaque independent of traditional cardiovascular risk factors. This finding suggests that CAC scanning may underestimate plaque burden in HIV?infected men. (Source: HIV Medicine)
Ten-year Survival by Race/Ethnicity and Sex Among Treated, HIV-infected Adults in the United States
Conclusions.&nbsp;These data serve as a call to action to identify modifiable mechanisms leading to these observed mortality disparities among HIV-infected black patients. Effective interventions are needed to ensure that the goal of the National HIV/AIDS Strategy to overcome health disparities becomes a reality. (Source: Clinical Infectious Diseases)
Valacyclovir Decreases Plasma HIV-1 RNA in HSV-2 Seronegative Individuals: A Randomized Placebo-Controlled Crossover Trial
Conclusions.&nbsp;These data indicate that the effects of valACV on HIV-1 replication are not related to the suppression of HSV-2-mediated inflammation and are consistent with a direct effect of ACV on HIV-1 replication. (Source: Clinical Infectious Diseases)
Impact of the Timing of Initiation of Antiretroviral Therapy During Primary HIV-1 Infection on the Decay of Cell-Associated HIV-DNA
Conclusions.&nbsp;This study provides strong arguments in favor of cART initiation at the earliest possible time point after HIV infection. (Source: Clinical Infectious Diseases)
A population-based study comparing patterns of care delivery on the quality of care for persons living with HIV in Ontario
Conclusions How care is provided had a potentially important influence on the quality of care delivered. Our key limitation is potential confounding due to the absence of HIV stage measures. (Source: BMJ Open)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
FDA Ready to Lift Ban on Blood Donations by Gay Men
Studies from other countries show such donations wouldn't compromise blood supply, health officials say (Source: Fertility News - Doctors Lounge)
Offer Smokers Variety of Cessation Options, Says USPSTF
The U.S. Preventive Services Task Force recently released a draft recommendation on smoking cessation in adults and recommends that physicians offer a variety of cessation aids, including behavioral therapy. (Source: AAFP News)
A single-loop recombinant pseudotyped-virus-based assay to detect HIV-1 phenotypic resistance
Abstract HIV/AIDS is a leading public health concern throughout the world. Currently, treatment of HIV/AIDS still depends on highly active antiretroviral therapy (HAART); however, there is increasing evidence showing the emergence of resistance to antiretroviral drugs in HIV-1 strains, making ART less effective over time. Intensive monitoring of HIV-1 drug resistance is therefore of great importance to evaluate the current sensitivity of antiretroviral agents and is urgently needed. The aim of this study was to develop a single-loop recombinant pseudotyped-virus-based assay to detect phenotypic resistance in clinical HIV-1 strains. HIV-1 RNA was extracted from HIV-1-infected human plasma samples, and an approximately 3-kb fragment containing p7/p1/p6 cleavage sites and full-lengt...
Dangerous Binge Drinking Has Increased Among Teens And Young Adults Around The Globe
PARIS (AP) ? Alcohol consumption in wealthy, developed countries has declined over the past two decades but dangerous binge drinking has increased among the young, according to a new study released Tuesday. The 34-nation Organization for Economic Cooperation and Development says average annual alcohol consumption in its member countries has fallen 2.5 percent over the past 20 years to 9.1 liters (2.4 gallons) of pure alcohol per capita. But that overall trend hides a dangerous increase in hazardous drinking by young people, the OECD says, as measured by both the amount and the rate that alcohol is consumed. The OECD warned that binge drinking by the young is a "major public health and social concern," with children taking up drinking at increasingly earlier ages. Harmful consumption o...
Africa: Johnson & Johnson Expands Ip Policy to Create Broad Access in 128 Countries for Development of New and Optimized HIV Medicine Formulations for Children Living With HIV
[PR Newswire] Raritan, New Jersey -Expanded Policy will Increase Access for Darunavir Pediatric Formulations in 128 Resource-Limited Countries (Source: AllAfrica News: HIV-Aids and STDs)
Angola: Angola - Government Committed to Protecting HIV/Aids Positive Children
[ANGOP] Luanda -The promotion of policies for the protection of children infected with and affected by HIV/Aids and the decrease of the stigma they face are some of the commitments of the Angolan government to tackle this pandemic disease in the country, said last Monday, in Luanda, the national director of the Institute of Fight against Aids (INLS), Ducelina Serrano. (Source: AllAfrica News: HIV-Aids and STDs)
Cell Counting Market to Growing at 6.5% - 7% to 2020: New Research...
Globally cell counting market witnessed healthy growth during the last decade due to the growing stem cell research and rising incidences of cancer and AIDS.(PRWeb May 11, 2015)Read the full story at http://www.prweb.com/releases/cell-counting-market/research-report-2020/prweb12712245.htm (Source: PRWeb: Medical Pharmaceuticals)
HIV immunity: rare gene differences offer hope for treatment
Seven years after the ?Berlin patient? was cured of HIV, scientists are looking to natural immunity through genetic variation to create vaccine and gene therapies Continue reading... (Source: Guardian Unlimited Science)
Kenya: Circumcision Does Not Prevent HIV/Aids, Migori Youth Warned
[The Star] Multi-pronged camapigns must be carried out in Migori county to alter the belief that circumcised men cannot contract HIV/Aids, an official has said. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Smoking cessation among transit workers: beliefs and perceptions among an at-risk occupational group
Conclusion: Beliefs play an important role and influence the extent to which transit workers participate in smoking cessation. Being cognizant of and addressing these beliefs so that workers gain an informed understanding is important when designing cessation programs. Doing so may help in creating tobacco cessation efforts that are seen as both attractive and beneficial to transit workers. (Source: BioMed Central)
Using Interactive Web-Based Screening, Brief Intervention and Referral to Treatment in an Urban, Safety-Net HIV Clinic
We examined whether patients would participate in a technology-based SBIRT program in an urban HIV clinic. An SBIRT intervention was programmed into the clinic?s web-based patient portal linked to their personal health record. We examined: demographic, health, HIV, and substance use characteristics of participants who completed the web-based intervention compared to those who did not. Fewer than half of the 96 participants assigned to the web-based SBIRT completed it (n = 39; 41 %). Participants who completed the web-based intervention had significantly higher amphetamine SSIS scores than those who did not complete the intervention. Participants whose substance use is more harmful may be more motivated to seek help from a variety of sources. In addition, it is important that technolog...
Using Capture-Recapture Methods to Estimate the Population of People Who Inject Drugs in Washington, DC
Abstract No current estimates exist for the size of the population of people who inject drugs (PWID) in the District of Columbia (DC). The WHO/UNAIDS Guidelines on Estimating the Size of Populations Most at Risk to HIV was used as the methodological framework to estimate the DC PWID population. The capture phase recruited harm reduction agency clients; the recapture phase recruited community-based PWID. The 951 participants were predominantly Black (83.9 %), male (69.8 %), and 40+ years of age (68.2 %). Approximately 50.3 % reported injecting drugs in the past 30 days. We estimate approximately 8829 (95 % CI 4899 and 12,759) PWID in DC. When adjusted for possible missed sub-populations of PWID, the estimate increases to 12,000; thus, the original estimate of approximately 90...
Explaining the Efficacy of Pre-exposure Prophylaxis (PrEP) for HIV Prevention: A Qualitative Study of Message Framing and Messaging Preferences Among US Men Who have Sex with Men
Abstract We investigated message comprehension and message framing preferences for communicating about PrEP efficacy with US MSM. We conducted eight focus groups (n = 38) and n = 56 individual interviews with MSM in Providence, RI. Facilitators probed comprehension, credibility, and acceptability of efficacy messages, including percentages, non-numerical paraphrases, efficacy ranges versus point estimates, and success- versus failure-framed messages. Our findings indicated a range of comprehension and operational understandings of efficacy messages. Participants tended to prefer percentage-based and success-framed messages, although preferences varied for communicating about efficacy using a single percentage versus a range. Participants reported uncertainty about how to i...
Usefulness of 18F-Fluorodeoxyglucose-position emission tomography with computed tomography and gallium-67 scintigraphy for detection of Kaposi sarcoma lesions in a 40-year-old Japanese man with AIDS
Publication date: Available online 11 May 2015 Source:IDCases Author(s): Jun Suzuki , Teppei Sasahara , Masaki Toshima , Masataro Norizuki , Tsubasa Onishi , Taro Okabe , Kensuke Minami , Yuji Morisawa A 40-year-old Japanese man with acquired immunodeficiency syndrome was diagnosed with Kaposi sarcoma (KS) on the basis of the results of skin lesion biopsies. In addition, 18F-fluorodeoxyglucose-position emission tomography-computed tomography revealed abnormal fluorodeoxyglucose uptake in KS lesions, whereas gallium-67 scintigraphy did not show uptake of gallium. These findings indicate that combining these imaging modalities can help distinguish KS from other malignancies and opportunistic infections. (Source: IDCases)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Longitudinal trends of recent HIV?1 infections in Slovenia (1986?2012) determined using an incidence algorithm
This study could help promote the idea of introducing periodic HIV incidence monitoring using a simple and affordable algorithm. J. Med. Virol.© 2015 Wiley Periodicals, Inc. (Source: Journal of Medical Virology)
The Lisbon Cohort of men who have sex with men
Purpose Newly diagnosed HIV infections among men who have sex with men (MSM) are rising in many European countries. Surveillance tools must be tailored to the current state of the epidemic, and include decentralised prospective monitoring of HIV incidence and behavioural changes in key populations. In this scenario, an open prospective cohort study was assembled&mdash;The Lisbon Cohort of MSM&mdash;aiming to dynamically monitor the frequency of disease and its predictors. Participants The Lisbon Cohort of MSM is an ongoing observational prospective study conducted at a community-based voluntary HIV counselling and testing centre in Lisbon, Portugal (CheckpointLX). Men testing negative for HIV, aged 18 or over and reporting having had sex with men are invited to follow-up visits every 6&nb...
Oxidative Stress and Epigenetic Modifications in the Pathogenesis of Diabetic Retinopathy
Publication date: Available online 11 May 2015 Source:Progress in Retinal and Eye Research Author(s): Renu A. Kowluru , Anjan Kowluru , Manish Mishra , Binit Kumar Diabetic retinopathy remains the major cause of blindness among working age adults. Although a number of metabolic abnormalities have been associated with its development, due to complex nature of this multi-factorial disease, a link between any specific abnormality and diabetic retinopathy remains largely speculative. Diabetes increases oxidative stress in the retina and its capillary cells, and overwhelming evidence suggests a bidirectional relationship between oxidative stress and other major metabolic abnormalities implicated in the development of diabetic retinopathy. Due to increased production of cytosolic reactive oxyg...
A Framework for Evaluating the Cost-Effectiveness of Patient Decision Aids: A Case Study Using Colorectal Cancer Screening
Conclusions This study provides proof-of-concept evidence for future studies examining the cost-effectiveness of decision aids. The results suggest that decision aids can be beneficial and cost-effective. (Source: Preventive Medicine)
South Africa: Basic Education Releases Draft National Policy on HIV, STIs and TB for Public Comment
[SA Govt] Basic Education invites comments from the public on the DBE Draft National Policy on HIV, STIs and TB (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Nigeria: I'll Pay Every HIV-Positive South African N0.84m to Wear a Tatoo - - Zuma
[Vanguard] CONFIRMED HIV positive South Africans that volunteer to be marked near their genital area with a tatoo depicting their status, will in addition to free counselling and medication. be paid an equivalent of N840, 000 (50 000 Rands) each, according to a bill newly signed by President Jacob Zuma. (Source: AllAfrica News: HIV-Aids and STDs)
Namibia: HIV/Aids Activists Hail Awareness Walk
[New Era] Local HIV/AIDS activists on Saturday hailed the walk aimed at promoting community awareness on HIV/AIDS, which was organised by the Immanuel Sheefeni AIDS Foundation. (Source: AllAfrica News: Health and Medicine)
Partnership Takes Aim at Curing HIV/AIDS
GlaxoSmithKline and UNC Chapel Hill are launching an HIV research center focused on finding a cure for the virus that causes AIDS. (Source: WSJ.com: Health)
High-Grade Anal Intraepithelial Neoplasia in HIV+ MSMHigh-Grade Anal Intraepithelial Neoplasia in HIV+ MSM
What risk factors predict the progression to high-grade anal intraepithelial neoplasia in HIV-infected MSM? AIDS (Source: Medscape Today Headlines)
Anogenital HIV RNA in Thai men who have sex with men in Bangkok during acute HIV infection and after randomization to standard vs. intensified antiretroviral regimens.
CONCLUSIONS: Among MSM with AHI, HIV RNA was highest in blood, followed by seminal plasma and anal lavage. ART rapidly reduced HIV RNA in all compartments, with regimen intensified by raltegravir and maraviroc showing faster HIV RNA reductions in blood and seminal plasma. PMID: 25956171 [PubMed - as supplied by publisher] (Source: Journal of the International AIDS Society)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Hunt for AIDS cure accelerates as GSK and U.S. experts link up
LONDON (Reuters) - Britain's GlaxoSmithKline, which decided last week to retain rather than float off its HIV drugs business, is to collaborate with U.S. scientists in developing a cure for AIDS. (Source: Reuters: Health)
Drugmaker and University Ally to Seek Cure for AIDS
GlaxoSmithKline will contribute a total of $20 million to start a research institute and a company with the goal of curing patients infected with H.I.V. (Source: NYT Health)
A moving blocks empirical likelihood method for longitudinal data
Summary In the analysis of longitudinal or panel data, neglecting the serial correlations among the repeated measurements within subjects may lead to inefficient inference. In particular, when the number of repeated measurements is large, it may be desirable to model the serial correlations more generally. An appealing approach is to accommodate the serial correlations nonparametrically. In this article, we propose a moving blocks empirical likelihood method for general estimating equations. Asymptotic results are derived under sequential limits. Simulation studies are conducted to investigate the finite sample performances of the proposed methods and compare them with the elementwise and subject?wise empirical likelihood methods of Wang et al. (2010, Biometrika 97, 79?93) and the bloc...
Zolpidem and eszopiclone prime ?1?2?2 GABAA receptors for longer duration of activity
Conclusions and ImplicationsAs the derived mechanism successfully simulated the effects of eszopiclone and zolpidem on ensemble currents, we propose it as the definitive mechanism accounting for the effects of both drugs. Importantly, eszopiclone and zolpidem enhanced GABAA receptor currents via a mechanism that differs from that proposed for benzodiazepines. (Source: British Journal of Pharmacology)
Pharmacokinetics of tenofovir during pregnancy and postpartum
ConclusionsThis study found lower tenofovir AUC and troughs during pregnancy. Transplacental passage with chronic TDF use during pregnancy was high. Standard TDF doses appear to be appropriate for most HIV?infected pregnant women but therapeutic drug monitoring with dose adjustment should be considered in pregnant women with high weight (&gt;?90?kg) or inadequate HIV RNA response. (Source: HIV Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Do GPs think patient decision aids are a useful tool?
A small survey among a group of GPs has identified certain barriers to the use of patient decision aids. But without such aids can we really claim to practice shared decision making? (Source: Prescriber)
A health promotion logic model to review progress in HIV prevention in China
Using the theory and concepts of health promotion, this paper proposes a logic model for HIV/AIDS prevention and control which provides a structure for describing planned actions and predicted impacts/outcomes from comprehensive HIV prevention interventions. The potential usefulness of the model is examined by reviewing the evolution of HIV prevention and management in China, drawing on evidence from interventions reported from a mixture of study designs and formats. It reports that HIV interventions in China can be considered in two distinctive phases, before and after 2003 when China commenced its &lsquo;official&rsquo; response to the HIV epidemic. The logic model was useful in comparing actions taken over these two periods highlighting the importance of political leadership in distingu...
Use of the Nerve Integrity Monitor during Thyroid Surgery Aids Identification of the External Branch of the Superior Laryngeal Nerve
Conclusion Using the NIM and meticulous dissection of the upper thyroid pole improves EBSLN identification. As the EBSLN is at risk during thyroidectomy and can lead to voice morbidity, the NIM can aid identification of the EBSLN and provide a functional assessment of the EBSLN after thyroid resection. (Source: Annals of Surgical Oncology)
The Psychological Context of Sexual Compulsivity Among Men Who Have Sex with Men
Abstract Among men who have sex with men (MSM), sexual compulsivity is associated with overlapping psychosocial and behavioral health problems. Because difficulties with emotion regulation are thought to be one important feature, this study examined whether affective states and traumatic stress symptoms were independently associated with key dimensions of sexual compulsivity. Data were collected in San Francisco for the Urban Men?s Health Study-2002 from May 24, 2002 to January 19, 2003. In total, 711 MSM recruited via probability-based sampling completed a mail-in questionnaire that assessed psychological factors and substance use. Dissociation related to traumatic stress and any stimulant use in the past 6 months were independently associated with more frequent sexual thought...
Social Cognition Variables and Victimization as Predictors of Sexual Debut Among Adolescents in South Africa and Tanzania: A Multi-group SEM Analysis
Abstract Early sexual debut is common in South Africa and Tanzania, with potentially negative reproductive health outcomes. The role of violence as a predictor of sexual debut was studied, in a context of predictors borrowed from social cognition models. Data were taken from cluster-randomized trials of school-based HIV prevention interventions in three sites in South Africa and Tanzania. Analyses consisted of descriptive statistics and multi-group structural equation modelling. The basic model functioned fairly well for Cape Town, but less well for Mankweng and Dar es Salaam (low R2 values). Attitudes were the strongest predictor of intention. Adding socio-demographic variables to the model did not reduce the associations much and neither did subsequent inclusion of violence. Sex...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Strategies to uncover undiagnosed HIV infection among heterosexuals at high risk and link them to HIV care with high retention: a &#8220;seek, test, treat, and retain&#8221; study
DiscussionHeterosexuals do not test for HIV as frequently as and are diagnosed later than other risk groups. The study has the potential to contribute an efficient, innovative, and sustainable multi-level recruitment approach and intervention to the HIV prevention portfolio. Because the majority of heterosexuals at high risk are African American/Black or Latino, the study has great potential to reduce racial/ethnic disparities in HIV/AIDS.Trial registrationClinicalTrials.gov, NCT01607541, Registered May 23, 2012. (Source: BMC Public Health)
Factors related to NT-proBNP levels in HIV patients aged over 40&#160;years
Conclusions: We found, with the limitations of a small serie, that higher levels of NTproBNP in HIV patients could be linked to the occurrence of cardiovascular events, this fact suggest that NTpro BNP could be used in patients at moderate or high vascular risk in order to optimise the primary prevention of vascular events. (Source: AIDS Research and Therapy)
The difficult management of disseminated Sporothrix brasiliensis in a patient with advanced AIDS.
This report describes a case of disseminated sporotrichosis caused by S. brasiliensis in a patient with advanced AIDS. The skin, lungs, bones and central nervous system were affected. Medical treatment involved the administration of amphotericin B, terbinafine, itraconazole and posaconazole. Posaconazole was associated with the best clinical response and clearing of the fungus from the central nervous system. PMID: 25949269 [PubMed] (Source: AIDS Research and Therapy)
Partner notification in the context of HIV: an interest-analysis.
We present an interest-analysis of partner notification in the context of HIV service rendition. Using principles-based analysis, the interests of the individual, the state/public health, and the bioethicist's are discussed. The public health interests in partner notification, which are usually backed by state statutes and evidence, are premised on the theory that partners are entitled to knowledge. This theory posits that knowledge empowers individuals to avoid continuing risks; knowledge of infection allows for early treatment; and that knowledgeable partners can adapt their behavior to prevent further transmission of infection to others. However, persons infected with HIV often have counter interests. For instance, an infected person may desire to maintain the privacy of their health st...
Insomnia Could Kill You -- By Accident
We talk a lot about the dangers of poor sleep, the risks to health, mental and physical well being and performance, and to quality of life. One serious consequence of poor sleep that sometimes gets overlooked? The risk it poses to accidental death. A recent study puts in stark relief the dangers that insomnia can pose by increasing the risks for unintended fatal injury. Researchers in Norway undertook a large-scale evaluation of the relationship between symptoms of insomnia and the risk of fatal accidental injury. Their study included 54,399 men and women between the ages 20-89, all of whom participated in a public health study during the years 1995-1997. Researchers collected data on participants over a 14-year period, collecting survey data about the presence of insomnia symptoms, incl...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Hospitalization Rates and Reasons Among HIV Elite Controllers and Persons With Medically Controlled HIV Infection
Conclusions.&nbsp;Elite controllers are hospitalized more frequently than persons with medically controlled HIV and cardiovascular hospitalizations are an important contributor. (Source: The Journal of Infectious Diseases)
Quantitative and Qualitative Antibody Responses to Immunization With the Pneumococcal Polysaccharide Vaccine in HIV-Infected Patients After Initiation of Antiretroviral Treatment: Results From a Randomized Clinical Trial
Conclusions.&nbsp;In HIV+ with CD4 &ge; 200, delaying PPV23 until &ge;6 months of ART does not improve responses and may lead to missed opportunities for immunization. (Source: The Journal of Infectious Diseases)
Association of Cytokines With Exosomes in the Plasma of HIV-1-Seropositive Individuals
Human immunodeficiency virus (HIV)-infected and viremic individuals exhibit elevated levels of plasma cytokines. Here we show that most cytokines are not in free form but appear associated with exosomes that are distinct from virions. Purified exosomes were analyzed to determine the levels of 21 cytokines and chemokines and compared with exosome-depleted plasma. Most cytokines were markedly enriched in exosomes from HIV-positive individuals relative to negative controls and to plasma. Moreover, exposure of naive peripheral blood mononuclear cells to exosomes purified from HIV-positive patients induced CD38 expression on naive and central memory CD4+ and CD8+ T cells, probably contributing to inflammation and viral propagation via bystander cell activation. (Source: The Journal of Infectiou...
Bone Marrow-Imprinted Gut-Homing of Plasmacytoid Dendritic Cells (pDCs) in Acute Simian Immunodeficiency Virus Infection Results in Massive Accumulation of Hyperfunctional CD4+ pDCs in the Mucosae
Plasmacytoid dendritic cells (pDCs), a primary source of interferon &alpha; (IFN-&alpha;), provide a first line of innate immune defense against human immunodeficiency virus infection. However, their kinetics and functions during acute infection are poorly understood. In mucosal tissues of normal rhesus macaques, we found CD4+ pDCs to be the subset responsible for most IFN-&alpha; and tumor necrosis factor &alpha; (TNF-&alpha;) production in response to Toll-like receptor (TLR) 7/8 stimulation, compared with relatively anergic CD4&ndash; pDCs. During acute simian immunodeficiency virus (SIV) infection, gut homing was imprinted on pDCs in the bone marrow, resulting in a decline in pDCs from circulation and secondary lymphoid tissues. Although the accumulated pDCs in the gut mucosae had robu...
Course and Clinical Significance of CD8+ T-Cell Counts in a Large Cohort of HIV-Infected Individuals
Conclusions.&nbsp;CD8+ T-cell counts are elevated during HIV infection and do not normalize despite long-term cART. Low CD8+ T-cell counts are associated with increased AIDS-related mortality. Marked elevations in CD8+ T-cell counts after long-term cART are associated with increased non&ndash;AIDS-related mortality. (Source: The Journal of Infectious Diseases)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Global Dispersal Pattern of HIV Type 1 Subtype CRF01_AE: A Genetic Trace of Human Mobility Related to Heterosexual Sexual Activities Centralized in Southeast Asia
Discussion.&nbsp;The central role of Thailand in the global spread of CRF01_AE can be probably explained by the popularity of Thailand as a vacation destination characterized by sex tourism and by Thai emigration to the Western world. Our study highlights the unique case of CRF01_AE, the only globally distributed non&ndash;B clade whose global dispersal did not originate in Africa. (Source: The Journal of Infectious Diseases)
Medroxyprogesterone Acetate Regulates HIV-1 Uptake and Transcytosis but Not Replication in Primary Genital Epithelial Cells, Resulting in Enhanced T-Cell Infection
Although clinical and experimental evidence indicates that female sex hormones and hormonal contraceptives regulate susceptibility to human immunodeficiency virus type 1 (HIV-1) infection, the underlying mechanism remains unknown. Genital epithelial cells (GECs) are the first cells to encounter HIV during sexual transmission and their interaction with HIV may determine the outcome of exposure. This is the first report that HIV uptake by GECs increased significantly in the presence of the hormonal contraceptive medroxyprogesterone acetate (MPA) and progesterone and that uptake occurred primarily via endocytosis. No productive infection was detected, but endocytosed virus was released into apical and basolateral compartments. Significantly higher viral transcytosis was observed in the presen...
High Transmissibility During Early HIV Infection Among Men Who Have Sex With Men--San Francisco, California
We estimate the relative transmission rate in early versus later infection among men who have sex with men (MSM) in San Francisco, California, by studying the characteristics of a sample of transmitters, recruited through newly diagnosed, recently infected MSM between 1996 and 2009. Of 36 transmitters identified, 9 were determined on the basis of testing history and serologic testing to have been recently infected. The unadjusted odds ratio of transmitting during early infection was 15.2 (95% confidence interval [CI], 6.3&ndash;33.4; P &lt; .001); the odds ratio was 8.9 (95% CI, 4.1&ndash;19.4) after adjustment for self-reported antiretroviral treatment. This high transmissibility could be due to both high infectiousness and high rates of sex partner change or concurrent partnerships. (Sou...
Do Surgeons Treat Their Patients Like They Would Treat Themselves?
CONCLUSIONS: Surgeons are slightly more likely to recommend surgery for a patient than they are to choose surgery for themselves and they choose for themselves with a little more confidence. Different perspectives, preferences, circumstantial information, and cognitive biases might explain the observed differences. This emphasizes the importance of (1) understanding patients' preferences and their considerations for treatment; (2) being aware that surgeons and patients might weigh various factors differently; (3) giving patients more autonomy by letting them balance risks and benefits themselves (ie, shared decision-making); and (4) assessing how dispassionate evidence-based decision aids help inform the patient and influences their decisional conflict. LEVEL OF EVIDENCE: Level III, di...
Polyomaviruses and disease: is there more to know than viremia and viruria?
Purpose of review: Polyomavirus nephropathy (PVN) mainly caused by BK virus (BKV) remains the most common productive viral infection of the kidney. Over the past decade, clinical interest often focused on BK viremia and viruria as the diagnostic mainstays of patient management. The purpose of this review is to discuss viral nephropathy in the context of BK viremia and viruria and new strategies to optimize diagnostic accuracy and patient management. The emerging roles of polyomaviruses in oncogenesis, salivary gland disease, and post-bone marrow transplantation as well as novel Polyomavirus strains are highlighted. Recent findings: Areas of investigation include proposals by the Banff working group on the classification of PVN and studies on PVN progression and resolution, including the ro...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
[Correspondence] A public health approach to hypertension
Sonia Angell and colleagues1 present constructive ideas to address hypertension globally. However, the daunting challenges of implementation of rapid control of hypertension deserve fuller discourse. The fact that ?in the USA, barely half of people with hypertension have their blood pressure at target levels?1 speaks volumes. Moreover emulating single-purpose AIDS programming is largely unrealistic. Undertaking of further multibillion dollar initiatives to establish largely parallel health systems is simply not feasible. (Source: LANCET)
Africa: Partnership Forum Focuses On Strategy
[Global Fund] Addis Ababa, Ethiopia -Partners in global health gathered here today to participate in consultations about the strategy the Global Fund partnership should implement to best accelerate the end of AIDS, tuberculosis and malaria as epidemics and to contribute to building resilient health systems. (Source: AllAfrica News: Health and Medicine)
Malawi: Key Correspondent Receives Malawi Media Award
[Key Correspondents] Key Correspondent Owen Nyaka has been awarded 'Best Paediatric and HIV Journalist of the Year' by the Malawi Chapter of the Media Institute of Southern Africa (MISA). (Source: AllAfrica News: HIV-Aids and STDs)
South Africa: Service Delivery to Improve At Clinic 2
[SAnews.gov.za] Pretoria -Residents of Soshanguve Block G in Pretoria have requested for more nurses to be employed at Clinic 2 to relieve one dedicated nurse who attends to patients living with HIV and Aids at the clinic. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: New Platform for Reports of Human Rights Violations in Global Fund Programs Launched
[GFO] A first response to complaints will be made within 48 hours (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Outstanding Directors 2015: Linda Washington Cropp
Linda Washington Cropp knows how to navigate boards: She served as the first-ever chairwoman of the Council of the District of Columbia from 1997 to 2007. But the guidance counselor-turned-politician has always had a flare for health care. While chairing the D.C. council?s Committee on Human Services, she helped create the city?s department of health and reorganized the agency to focus on priorities like substance abuse, infant mortality and HIV/AIDs. Thus, Cropp was a natural fit for CareFirst? (Source: bizjournals.com Health Care:Hospitals headlines)
Kenya: Aids Conference Starts in Nairobi
[The Star] SCIENTISTS and policymakers converged in Nairobi yesterday to develop local solutions for HIV-Aids response. (Source: AllAfrica News: HIV-Aids and STDs)
Self-Reported HIV and HCV Screening Rates and Serostatus Among Substance Abuse Treatment Patients
Abstract Substance users are at increased risk for HIV and HCV infection. Still, many substance use treatment programs (SUTP) fail to offer HIV/HCV testing. The present secondary analysis of screening data from a multi-site randomized trial of rapid HIV testing examines self-reported HIV/HCV testing patterns and serostatus of 2473 SUTP patients in 12 community-based sites that had not previously offered on-site testing. Results indicate that most respondents screened for the randomized trial tested more than a year prior to intake for HIV (52 %) and HCV (38 %). Prevalence rates were 3.6 and 30 % for HIV and HCV, respectively. The majority of participants that were HIV (52.2 %) and HCV-positive (40.5 %) reported having been diagnosed within the last 1?5 years. Multivari...
"Drugs That Fight HIV-1" Brochure Recently Updated
The "Drugs That Fight HIV-1" brochure has been updated to include antiretroviral (ARV) drugs recently approved by FDA. The NIH publication features images of FDA-approved ARVs, grouped by drug class and identified by both generic and brand names. The brochure, available in both English and Spanish, offers health care professionals a visual aid to use when discussing HIV treatment with patients. The brochure can be found in the HIV/AIDS Images section of Health Topics on our website. &nbsp; For more information on FDA-approved and investigational HIV/AIDS-related medications, please visit our Drug Database or download the AIDSinfo Drug Database app. The free app provides on-the-go access to the same information found in our Drug Database. The app is available for Apple and Android devices ...
May 18 is HIV Vaccine Awareness Day
Join AIDSinfo in observing HIV Vaccine Awareness Day on May 18. The annual observance is dedicated to the many scientists, health professionals, community members, and volunteers who are collaborating to develop both preventive and therapeutic HIV vaccines. Visit our HIV Vaccine Awareness Day webpage to learn more about the annual observance and about advances in HIV vaccine research. (Source: AIDSinfo At-a-Glance: Offering Information on HIV/AIDS Treatment, Prevention, and Research, A Service of the U.S. Department of Health and Human Services (DHHS))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
May 19 is National Asian and Pacific Islander HIV/AIDS Awareness Day
. This observance aims to raise awareness about HIV/AIDS in Asian and Pacific Islander communities. Explore our National Asian and Pacific Islander HIV/AIDS Awareness Day webpage to learn more about the observance and about research related to HIV/AIDS and Asians and Pacific Islanders. (Source: AIDSinfo At-a-Glance: Offering Information on HIV/AIDS Treatment, Prevention, and Research, A Service of the U.S. Department of Health and Human Services (DHHS))
SIV Encephalitis Lesions Are Composed of CD163 Macrophages Present in the Central Nervous System during Early SIV Infection and SIV-Positive Macrophages Recruited Terminally with AIDS
Macrophage recruitment to the central nervous system (CNS) during AIDS pathogenesis is poorly understood. We measured the accumulation of brain perivascular (CD163+) and inflammatory (MAC387+) macrophages in SIV-infected monkeys. Monocyte progenitors were 5-bromo-2?-deoxyuridine (BrdU) labeled in bone marrow, and CNS macrophages were labeled serially with fluorescent dextrans injected into the cisterna magna. MAC387+ macrophages accumulated in the meninges and choroid plexus in early inflammation and in the perivascular space and SIV encephalitis (SIVE) lesions late. (Source: American Journal of Pathology)
Comparison of the 2-step tuberculin skin test and QuantiFERON-TB Gold in-Tube test in the screening of latent tuberculosis infection in cancer patients
This study suggests that the QFT-GIT test maintains its sensitivity and performance in immunocompromised cancer patients, identifying a large number of truly infected patients being anergy to the tuberculin skin test. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Discriminatory attitudes toward people living with HIV among health care workers in Aceh, Indonesia: A vista from a very low HIV caseload region
Conclusions Our study found that knowledge on transmission and prevention of HIV, value-driven stigma and overestimated risk to HIV transmission are the only significant predictors of discriminatory attitudes towards PLHIV among HCWs in Aceh. Therefore to reduce those factors, trainings on HIV-related discrimination to HCWs and clear guidelines and protocols related to PLHIV care are urgently needed. (Source: Clinical Epidemiology and Global Health)
Targeting of Aids Related Encephalopathy Using Phenylalanine Anchored Lipidic Nanocarrier
Publication date: Available online 2 May 2015 Source:Colloids and Surfaces B: Biointerfaces Author(s): Anil Vyas , Ankit Jain , Pooja Hurkat , Ashish Jain , Sanjay K. Jain Transport of the anti-HIV agents across the blood brain barrier (BBB) is a prerequisite to treat acquired immunodeficiency syndrome (AIDS) related encephalopathy. In the present study, we explored facilitated transport of efavirenz (EFV, a non-nucleoside reverse transcriptase inhibitor) across BBB using phenylalanine anchored solid lipid nanoparticles (PA-SLN). PA (amino acid micro-nutrient) was used as a ligand which facilitated carrier mediated transport (CMT) via L-amino acid transporter i.e. LAT1 to traverse BBB. PA was coupled to SLN via amide linkage using carbodiimide chemistry and coupling was confirmed by comp...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Pre-HIV Test Counseling and the Perpetuation of Stigma
(Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
The Montreal Cognitive Assessment: A Pilot Study of a Brief Screening Tool for Mild and Moderate Cognitive Impairment in HIV-Positive Veterans
HIV-associated neurocognitive disorders (HANDs) are common, often go undetected, and can impact treatment outcomes. There is limited evidence on how to perform routine cognitive screening in HIV clinical settings. To address this, 44 HIV-positive males were recruited from a Veteran Affairs Infectious Disease clinic and completed the Montreal Cognitive Assessment (MoCA), International HIV Dementia Scale (IHDS), and Depression Anxiety and Stress Scale-21. In all, 50% scored below the MoCA cutoff and 36% scored below the IHDS cutoff. Current CD4 was the strongest predictor of an abnormal MoCA score (P = .007, 95% confidence interval [CI]: 0.987-0.998) and elevated depression was the second strongest predictor (P = .008, CI: 1.043-1.326). Combination antiviral therapy use and age were not sign...
Daptomycin Experience in Patients with Human Immunodeficiency Virus and Resistant Gram-Positive Infections
Conclusions: In HIV-infected patients, daptomycin appears to be a useful agent for treating resistant GPIs. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
STD Clinic Patients' Awareness of Non-AIDS Complications of HIV Infection
Participants were recruited from a sexually transmitted disease (STD) clinic in Florida and were assessed regarding the knowledge and awareness of non-AIDS conditions associated with HIV infection. Questionnaires were administered before and after a brief information session on non-AIDS conditions associated with HIV infection. Participants included men (n = 46) and women (n = 51). Prior to the information session, at baseline, only 34% of the participants were worried about HIV infection. Most participants (82%) agreed that HIV could be treated with antiretroviral therapy (ART), while only 38% were aware that HIV-associated conditions cannot be easily treated with ART. After the information session, almost all participants reported they were concerned regarding the risk of HIV infection. ...
Initial Experience with the Use of Thrombopoetin Receptor Agonists in Patients with Refractory HIV-Associated Immune Thrombocytopenic Purpura: A Case Series
HIV-associated immune thrombocytopenic purpura (ITP) has decreased in incidence 10-fold since the advent of highly active antiretroviral therapy (HAART). For patients with detectable HIV viral loads, first-line treatment approaches involve optimizing HAART followed by standard ITP options used to treat those without HIV infection. In the general population, the thrombopoetin receptor agonists (TRAs), eltrombopag and romiplostim, are effective when used as salvage ITP therapy. In addition, eltrombopag has been used effectively in patients with thrombocytopenia secondary to hepatitis C&mdash;a virus seen commonly in HIV-infected patients, especially in those who also have a history of intravenous drug use. There are, however, few reports or studies of TRAs use in those with HIV infection. He...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
The Continuing Challenge of Reducing HIV Risk among Haitian Youth: The Need for Intervention
There is a dire need for interventions that will address the multiple factors&mdash;poverty, substance use, early sexual debut, and violence&mdash;that influence Haitian youth&rsquo;s engagement in risky behaviors. The deteriorating socioeconomic and political state of the country has had a deleterious effect on the sociocultural milieu and on the boundaries that have heretofore kept risky behaviors in check. Historically, the lakou system, a community-based approach that supports the family unit, has disintegrated, leading to the disruption of traditional parenting patterns. The unstable economic system has also led to the increasing use of children from poor families, who through the restavek system, are sent to work as servants in other households. The breakdown of traditional systems, ...
How Setswana Cultural Beliefs and Practices on Sexuality Affect Teachers' and Adolescents' Sexual Decisions, Practices, and Experiences as well as HIV/AIDS and STI Prevention in Select Botswanan Secondary Schools
This article reports the results of a survey of a sample of teachers and students at junior secondary schools and senior secondary schools, first, on their views and opinions regarding the Talk Back program as a TCBP. Second, how Setswana cultural beliefs, myths, and practices on sexuality affect teachers&rsquo; and adolescents&rsquo; sexual decisions, practices, and experiences as well as HIV/AIDS and sexually transmitted infection prevention. A questionnaire survey and focus group interviews were used as data collection instruments in selected secondary schools. The findings of the study suggest that the Talk Back program has not met much success as a TCBP. The findings further suggest that several myths, beliefs, misconceptions, and attitudes about HIV/AIDS exist among Botswana teachers...
Predictors of HIV Serodiscordance among Couples in Southwestern Ethiopia
Conclusion: The prevalence of serodiscordance in the study area was found to be low, but it contributes to a clinically significant population that mandates implementation of preventive strategy. Sero-positive individuals who use condoms rarely should be encouraged to have their partners tested, and the association between active TB and serodiscordance underscores the need for further study. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
Cervical Cancer Screening among HIV-Positive Women in Nigeria: An Assessment of Use and Willingness to Pay in the Absence of Donor Support
Conclusion: Willingness to pay for Pap smear by HIV-positive women in Enugu, Nigeria, is high. This has implication for the program sustainability. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
Clinician Perspectives on Delaying Initiation of Antiretroviral Therapy for Clinically Eligible HIV-Infected Patients
Conclusion: Reasons for delaying ART were consistent with clinical guidelines and were both patient level and structural. Providers may benefit from training and access to referrals for ancillary services to enhance their ability to monitor and address these issues with their patients. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Determinants of Survival in Adult HIV Clients on Antiretroviral Therapy in Lawra and Jirapa Districts of Upper West Region, Ghana
We describe the rate of death and identify the determinants of survival in a cohort of adults starting antiretroviral therapy (ART) in 2 hospitals in Upper West Region, Ghana. Kaplan-Meier model was used to estimate the survival probability after ART initiation and Cox proportional hazard model used to assess the relationship between baseline variables and mortality. A total of 91 clients who were initiated on ART in both hospitals participated in the study. Clients staged in the World Health Organization (WHO) clinical stage III/IV had a higher risk of mortality than those staging I/II (hazard ratio [HR] of 3.93). Hemoglobin value at baseline with a cutoff &ge;12 g/dL for women (and &ge;13 for men) was strongly associated with mortality in participants with an HR of 3.87 (95% confidence i...
Neutropenia in HIV-Infected Kenyan Women Receiving Triple Antiretroviral Prophylaxis to Prevent Mother-to-Child HIV Transmission Is Not Associated with Serious Clinical Sequelae
Conclusion: More than half of KiBS women met criteria for neutropenia. The mild clinical experience of most participants with low ANCs supports that these values might be typical for this population and may not result in adverse clinical sequelae. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
Predictors of Mortality among Tuberculosis/HIV-Coinfected Persons in Southwest Ethiopia: A Case-Control Study
Conclusion: Mortality among TB/HIV-coinfected patients accounted for a considerable number of deaths among the cohort. Patients with cough at ART initiation and with poor functional status should be strictly followed to reduce death. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
Boundaries of confidentiality in nursing care for mother and child in HIV programmes.
DISCUSSION: The material indicates a delicate balance between the nurses' attempt to secure the HIV-free survival of the babies and the mothers' desire to preserve confidentiality. Profound confidentiality-related dilemmas emerged in actual practice, and indications of a lack of thorough consideration of the implication of a patient's restricted disclosure came to light during follow-up of the HIV-positive women and the third party - the child who is at risk of HIV infection through mother's milk. World Health Organization's substantial focus on infant survival (Millennium Development Goal-4) and the strong calls for disclosure among the HIV-positive are reflected on in the discussion. PMID: 25956154 [PubMed - as supplied by publisher] (Source: Nursing Ethics)
Clinical performance and safety of adapters for intradermal delivery with conventional and autodisable syringes.
Authors: Tsals I, Jarrahian C, Snyder FE, Saganic L, Saxon E, Zehrung D, Zimmerman G, Papania M, Klaff L Abstract Although the number of vaccines and diagnostic tests currently delivered intradermally is limited, this route of administration offers potential advantages due to the high concentration of antigen-presenting cells in the skin. One factor which may in part be limiting development and use of intradermal (ID) administration is concern about the ease and reliability of the needle and syringe-based Mantoux technique. A phase I clinical study was conducted to evaluate two ID adapters that have been developed as injection-delivery aids to increase the safety, simplicity, and reliability of ID injection: a prototype autodisable, intradermal (ADID) adapter for autodisable (AD) s...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Necessity of Systematic HIV Disclosure in HIV-infected Families: Committed Communities Development Trusts Approach and Intervention.
Authors: Dwivedi P, Patkar P, Beard J Abstract Due to greater access to antiretroviral therapy, telling adolescents that they are HIV-infected and/or affected has become an integral and intricate part of the treatment protocol. Despite growing treatment resources from public and private sectors, there is a lack of systematic disclosure for children and adolescents affected and living with HIV/AIDS. Committed Communities Development Trust, a non-government organization working with children and adults infected with and/or affected by HIV, conducted a mixed-methods, cross-sectional study with 33 families in their home-based care program to evaluate their current disclosure protocol. The findings indicate that these experiences implementing and fine-tuning this protocol provide useful...
VIDEO: Aids can be eradicated, says Elton
Sir Elton John says he believes Aids can be eradicated in his lifetime if research funding is continued. (Source: BBC News | Health | UK Edition)
Starting a Juice Cleanse? 4 Things You Need to Know
Juices cleanses are a trendy weight-loss method. Proponents of juice cleanses claim you will lose weight and remove toxins from your body. Is it really healthy to only have liquids for as long as a week? If you don't get enough fruits and vegetables in your diet, juicing may help in that area. In most cases, a 3 to 5 day juice cleanse may not hurt you, but it won't necessarily help your overall health very much either. Consider these 4 facts before deciding whether a juice cleanse is right for you. 1. We don't really need a "cleanse" to remove toxins from our bodies. Proponents of juicing often claim that these "cleanses" will remove toxins from the body. However, we already have a "cleansing" mechanism in our bodies -- the liver, kidneys and intestines. The job of these organs is to ...
Liberia: UNAIDS Urges Support to HIV/Aids Program
[NEWS] UNAIDS Country Director, Dr. BetruWoldesemayat, has called on participants at the just-ended Joint UNAIDS and partners retreat, to make significant contributions to develop the new UN Joint Program of Support to HIV/AIDS in Liberia. (Source: AllAfrica News: HIV-Aids and STDs)
Africa: Innovation for Greater Impact - Exploring Domestic Resource Mobilization Efforts in Collaboration With the Global Fund
[GFO] As Aidspan has explored previously, international aid for AIDS, tuberculosis and malaria is plateauing, and a critical transition is underway to find more sustainable approaches to health financing in implementing countries. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Liberia: Curbing Spread of HIV Requires Political Commitmen
[New Republic] The Chairman of the National AIDS Commission (NAC), Dr. Ivan F. Camanor, has called for increased political commitment, domestic resource mobilization, scaled-up treatment and support services to curb the spread of HIV in the country. (Source: AllAfrica News: HIV-Aids and STDs)
Nigeria: Revealed - 10,606 Lagosians Test HIV Positive in One Year
[Independent (Lagos)] The Lagos State Commissioner for Health, Dr Jide Idris, has said that no fewer than 10, 606 people resident in the state have tested HIV positive. (Source: AllAfrica News: HIV-Aids and STDs)
Elton John to Congress: You have "the power to end AIDS"
In passionate testimony, musician and HIV/AIDS activist thanks lawmakers for past efforts to combat the virus, urges further action (Source: Health News: CBSNews.com)
MnO2 Nanosheets: One?Step Synthesis of Single?Layer MnO2 Nanosheets with Multi?Role Sodium Dodecyl Sulfate for High?Performance Pseudocapacitors (Small 18/2015)
One?step synthesis of single?Layer MnO2 nanosheets with multi?role sodium dodecyl sulfate (SDS) is demonstrated by H. Sun, S. Yin, and co?workers on page 2182. Interestingly, SDS, normally recognized as a surfactant, not only aids the formation of single?layer MnO2 nanosheets as a structure?inducing agent, but also serves as the precursor of dodecanol to reduce KMnO4. A mechanism is proposed based on carefully designed control experiments and the resultant MnO2 nanosheets exhibit high specific capacitance and excellent durability. (Source: Small)
Watchful waiting or induction of labour &#8211; a matter of informed choice: identification, analysis and critical appraisal of decision aids and patient information regarding care options for women with uncomplicated singleton late and post term pregnancies: a review
Conclusions: There is an urgent need for the design of an evidence-based decision aid of good quality for late-term or post-term pregnancy, particularly in German language. (Source: BMC Complementary and Alternative Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Nontuberculous Mycobacteria
Skin and soft tissue infections caused by nontuberculous mycobacteria are increasing in incidence. The nontuberculous mycobacteria are environmental, acid-fast bacilli that cause cutaneous infections primarily after trauma, surgery and cosmetic procedures. Skin findings include abscesses, sporotrichoid nodules or ulcers, but also less distinctive signs. Important species include Mycobacterium marinum and the rapidly growing mycobacterium: M. fortuitum, M. abscessus and M. chelonae. Obtaining tissue for mycobacterial culture and histopathology aids diagnosis. Optimal therapy is not well-established, but is species-dependent and generally dictated by susceptibility studies. Management often includes use of multiple antibiotics for several months and potential use of adjunctive surgery. (Sour...
The difficult management of disseminated Sporothrix brasiliensis in a patient with advanced AIDS
Sporotrichosis is an infection caused by a dimorphic fungus of the Sporothrix schenckii complex. Host immunity is an important factor in the clinical manifestations of the disease. Deeply immunocompromised individuals, especially those infected with the Human Immunodeficiency Virus (HIV) and T CD4 counts? (Source: AIDS Research and Therapy)
Rapid regression of Kaposi?s sarcoma of the hard palate under therapy with boosted elvitegravir-containing fixdose antiretroviral combination therapy
Conclusion In this case of a treatment-naive HIV-infected patient with coexisting KS, antiretroviral therapy with E/c/FTC/TDF was very well suited to achieve rapid complete remission of KS. (Source: Infection)
Meaning of care for terminally-ill HIV-infected patients by HIV-infected peer caregivers in a simulation-based training program in South Korea
The purpose of this study was to develop a simulation-based training program for people living with HIV (PLWH) as peer caregivers who would take care of terminally ill, HIV-infected patients. We used qualitative research methods and standardized patients to explore the meaning of caring for patients as peer caregivers. Study participants included 32 patients registered as PLWH at the South Korea Federation for HIV/AIDS. The meanings of peer caregiving were categorized into 4 dimensions: physical, psychological, relational, and economic. (Source: Journal of the Association of Nurses in AIDS Care)
Contraceptive need and use among individuals with HIV/AIDS living in the slums of Nairobi, Kenya
To understand contraceptive need and use among individuals with HIV/AIDS living in slums. (Source: International Journal of Gynaecology and Obstetrics)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
A New Zealand pilot randomized controlled trial of a web-based interactive self-management programme (MSInvigor8) with and without email support for the treatment of multiple sclerosis fatigue.
CONCLUSIONS: MSInvigor8 delivered with email-based support is a potentially promising, acceptable, and cost-effective approach to treating fatigue in people with multiple sclerosis in New Zealand. PMID: 25952587 [PubMed - as supplied by publisher] (Source: Clinical Rehabilitation)
Fragment-Based QSAR and Structural Analysis of a Series of Hydroxyethylamine Derivatives as HIV-1 Protease Inhibitors.
Authors: Ferreira LG, Andricopulo AD Abstract HIV-1 protease is a key enzyme for viral maturation because it cleaves precursor polypeptides into mature structural and functional proteins. The introduction of protease inhibitors into therapy in the mid-1990s has dramatically changed the AIDS panorama worldwide. However, resistance to currently available protease inhibitors remains a serious challenge that must be overcome. Herein, we report a fragment-based QSAR study of a series of highly potent HIV-1 protease inhibitors, as well as the structural basis of their binding affinity. Hologram QSAR (HQSAR) analyses were performed, resulting in robust statistical models that consistently correlated the bioactivity profile with the two-dimensional molecular descriptors. The robustness of ...
Therapy Stratifications and Novel Approach in Pursuit of Aids Related Kaposi's Sarcoma Management - A Paradigm for Non Invasiveness.
Authors: Sharma M, Sharma V, Pathak K Abstract Cancer in individuals suffering with HIV and AIDS has become a common source of morbidity and mortality, especially in the underdeveloped world in which Kaposi's sarcoma is the most occurring tumor of vascular endothelium frequently seen in patients suffering from AIDS. Suffering individuals are invariably co-infected with HIV and HHV-8 virus. The conventional modes for chemotherapies may be clinically useful in patients with kaposi's sarcoma. Though advancements in treatment modalities of AIDS related Kaposi's sarcoma have been successfully achieved, till date an exclusive therapy of golden standard has not been principally defined that can deliver the drug via non-invasive route. Novel concepts of treatment primarily address the fact...
Nutritional status and its association with quality of life among people living with HIV attending public anti-retroviral therapy sites of Kathmandu Valley, Nepal.
CONCLUSION: Nutrition interventions should form an integral part of HIV care programs. Understanding the presence of OI, decline in CD4 count, and advancing WHO clinical stages as risk factors can be helpful in preventing under nutrition from developing. Longitudinal research is necessary to further explicate associations between nutritional status and QoL. PMID: 25937825 [PubMed] (Source: AIDS Research and Therapy)
Tonsillectomy Appears to Protect Against Tonsil CancerTonsillectomy Appears to Protect Against Tonsil Cancer
Danish data also correlate the decline of tonsillectomies and the rise of oropharyngeal cancer over time. Medscape Medical News (Source: Medscape Hiv-Aids Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Elton John: U.S. Congress "has the power to end AIDS"
Musician and activist Sir Elton John thanks the U.S. Congress for its prior efforts on HIV/AIDS relief and urges further action to end the epidemic. (Source: Health News: CBSNews.com)
GlaxoSmithKline scraps float plans for HIV business
Drugmaker decides to retain ViiV Healthcare as part of a plan to revive performance and boost growth in emerging markets Continue reading... (Source: Guardian Unlimited Science)
National Institute of Allergy and Infectious Diseases (NIAID): HIV/AIDS
NIAID supports research at NIH, universities, medical centers, and clinical trial sites around the globe to better understand HIV and how it causes disease, find new tools to prevent HIV infection, develop new and more effective treatments for HIV-infected people, and find a cure. (Source: PHPartners.org)
More Aging Americans Using Canes, Walkers
Many seniors rely on more than one mobility device, study finds Source: HealthDay Related MedlinePlus Pages: Mobility Aids, Seniors' Health (Source: MedlinePlus Health News)
Liberia: 'Together We Can End HIV in the Post 2015 Era'
[New Republic] President Ellen Johnson Sirleaf has called on all Liberians to end the spread of HIV infection as part of the country's post 2015 development agenda. The president made the call Tuesday April 28, 2015 at the National AIDS Commission (NAC) Board of Directors Meeting held in the C. Cecil Dennis, Jr. Auditorium of the Ministry of Foreign Affairs in Monrovia. (Source: AllAfrica News: HIV-Aids and STDs)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Directory of the best <a href="http://www.thejanuarysales.com/">January Sales</a> in the UK. Find the best <a href="http://www.thejanuarysales.com/">Christmas presents</a> too.</p></div>
Nigeria: Malaria - WDI Facilitates Free Treatment in Alimosho
[Vanguard] In a bid to reduce absenteeism from work and eliminate the scourge of malaria, Westfield Development Initiative, WDI a non-governmental orgainsation has offered free malaria treatment to the resident of Alimosho Local Government Area of Lagos state. The programme which has over 700 people in attendance offer free malaria treatment, HIV/AIDs screening, blood pressure test, blood sugar tests, and free insecticide treated mosquito nets. (Source: AllAfrica News: Health and Medicine)
Liberia: 'Together We Can End HIV in the Post 2015 Era'
[New Republic] President Ellen Johnson Sirleaf has called on all Liberians to end the spread of HIV infection as part of the country's post 2015 development agenda. The president made the call Tuesday April 28, 2015 at the National AIDS Commission (NAC) Board of Directors Meeting held in the C. Cecil Dennis, Jr. Auditorium of the Ministry of Foreign Affairs in Monrovia. (Source: AllAfrica News: Health and Medicine)
Obesity in Ireland ?worse than HIV/AIDS in the 1980s?
Ireland set to be the most obese country in Europe by 2030, WHO says (Source: The Irish Times - Health)
Zimbabwe: Man Abuses HIV+ Wife, Court Told
[The Herald] A Harare man is chasing away his HIV-positive wife from their matrimonial home, saying he can no longer stay with her because she is "rotten", the Civil Court heard yesterday.Susan Machingura claimed her husband Sergio Tarwirei was in the habit of physically abusing her and locking her outside the house at night because of her HIV status. (Source: AllAfrica News: HIV-Aids and STDs)

 

 


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